1. Prostate cancer detection with magnetic resonance-ultrasound fusion biopsy: The role of systematic and targeted biopsies
- Author
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Filson, Christopher P, Natarajan, Shyam, Margolis, Daniel JA, Huang, Jiaoti, Lieu, Patricia, Dorey, Frederick J, Reiter, Robert E, and Marks, Leonard S
- Subjects
Male ,Image-Guided Biopsy ,Urologic Diseases ,diagnostic imaging ,Biopsy ,Oncology and Carcinogenesis ,Multimodal Imaging ,Predictive Value of Tests ,Clinical Research ,Needle ,Odds Ratio ,Humans ,magnetic resonance imaging ,Prospective Studies ,Oncology & Carcinogenesis ,Ultrasonography ,Aged ,Cancer ,screening and diagnosis ,Tumor ,Interventional ,cancer staging ,Prevention ,Prostate Cancer ,Prostatic Neoplasms ,Prostate-Specific Antigen ,Middle Aged ,Detection ,Public Health and Health Services ,Biomedical Imaging ,Biomarkers ,4.2 Evaluation of markers and technologies - Abstract
BackgroundThe current study was conducted to evaluate the performance of magnetic resonance (MR)-ultrasound-guided fusion biopsy in diagnosing clinically significant prostate cancer (csCaP).MethodsA total of 1042 men underwent multiparametric MR imaging (mpMRI) and fusion biopsy consecutively in a prospective trial (2009-2014). An expert reader graded mpMRI regions of interest (ROIs) as 1 to 5 using published protocols. The fusion biopsy device was used to obtain targeted cores from ROIs (when present) followed by a fusion image-guided, 12-core systematic biopsy in all men, even if no suspicious ROI was noted. The primary endpoint of the study was the detection of csCaP (ie, Gleason score ≥ 7).ResultsAmong 825 men with ≥ 1 suspicious ROI of ≥ grade 3, 289 (35%) were found to have csCaP. Powerful predictors of csCaP were ROI grade (grade 5 vs grade 3: odds ratio, 6.5 [P
- Published
- 2016