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1. Renal impairment associated with tenofovir disoproxil fumarate for antiretroviral therapy and HIV pre-exposure prophylaxis: An observational cohort study

Author

Heron, JE, McManus, H, Vickers, T, Ryan, K, Wright, E, Carter, A, Stoove, Mark, Asselin, J, Grulich, A, Donovan, B, Guy, R, Varma, R, Chen, M, Ryder, N, Lewis, DA, Templeton, DJ, O’Connor, CC, Gracey, DM, Bastian, L, Bateson, D, Bowden, S, Boyd, M, Callander, D, Aung, HL, Cogle, A, Costello, J, Dimech, W, Dittmer, J, El-Hayek, C, Ellard, Jeannette, Fairley, C, Franklin, L, Hellard, M, Hocking, J, Kim, J, McGill, S, Nolan, D, Patel, P, Pendle, S, Polkinghorne, V, Nguyen, L, Nguyen, T, O’Connor, C, Reed, P, Roth, N, Selvey, C, Traeger, M, Walker, M, and West, M

Subjects
Uncategorized
Abstract

Background: Tenofovir disoproxil fumarate (TDF) is associated with adverse renal outcomes when prescribed for HIV infection. There are few data concerning real-world renal outcomes amongst patients prescribed TDF for pre-exposure prophylaxis (PrEP). Methods and findings: Data were extracted from 52 sexual health clinics across Australia from 2009–2019. All patients prescribed TDF-containing antiretroviral therapy and PrEP were included. Rates of renal impairment (a fall in eGFR to

Published
2023
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2. Positive behaviour support for people with dementia

Author

Connolly T, O'Connor C, Kelly G, and Fisher A

Subjects
Gerontology, Text mining, business.industry, medicine, Dementia, medicine.disease, business, Psychology
Abstract

Aim: Behavioural changes following dementia can have detrimental effects on the quality of life of the individual and family members. In the current service context there is an increasing emphasis on the use of non-pharmacological interventions that aim to both ameliorate behaviour problems and improve quality of life. One relevant clinical framework is Positive Behaviour Support (PBS). This paper introduces the framework, its operationalisation, and some unresolved issues. Methods: Relevant literature and professional experience informs the theoretical and clinical justification for the use of PBS in dementia services, and a case study demonstrates application of the framework. Results: PBS can be effectively implemented in dementia contexts, but there are significant issues to be resolved regarding resourcing and appropriate goal setting. Conclusions: Further research is necessary to address skill development among clinicians, a supportive service, and limitations of this framework in the context of a progressive disease process.

Published
2021
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3. Measurement of the Charge-Averaged Elastic Lepton-Proton Scattering Cross Section by the OLYMPUS Experiment

Author

Bernauer, J. C., Schmidt, A., Avetisyan, A., Beck, R., Belostotski, S., Bessuille, J., Brinker, F., Calarco, J. R., Carassiti, V., Cisbani, E., Ciullo, G., Contalbrigo, M., Henderson, B. S., De Leo, R., Diefenbach, J., Donnelly, T. W., Dow, K., Elbakian, G., Eversheim, P. D., Frullani, S., Funke, Ch., Gavrilov, G., Gläser, B., Ice, L. D., Görrissen, N., Hasell, D. K., Hauschildt, J., Hoffmeister, Ph., Holler, Y., Ihloff, E., Izotov, A., Kaiser, R., Karyan, G., Kelsey, J., Khaneft, D., Kiselev, A., Klassen, P., Krivshich, A., Kohl, M., Lehmann, I., Lenisa, P., Lenz, D., Lumsden, S., Ma, Y., Maas, F., O'Connor, C., Marukyan, H., Miklukho, O., Milner, R. G., Movsisyan, A., Murray, M., Naryshkin, Y., Benito, R. Perez, Perrino, R., Redwine, R. P., Piñeiro, D. Rodríguez, Russell, R., Rosner, G., Schneekloth, Uwe, Seitz, B., Statera, M., Thiel, A., Vardanyan, H., Veretennikov, D., Vidal, C., Winnebeck, A., Yeganov, V., Akopov, N., Olympus Collaboration, Alarcon, R., and Ates, O.

Subjects
Proton, Physics::Instrumentation and Detectors, electromagnetic [calorimeter], elastic scattering, General Physics and Astronomy, Electron, momentum transfer dependence, 01 natural sciences, Economica, electromagnetic form factors, DESY Lab, Nuclear Experiment (nucl-ex), Nuclear Experiment, Physics, Elastic scattering, Luminosity (scattering theory), Form factor (quantum field theory), elastic scattering [cross section], recoil [p], beam [positron], target [hydrogen], electromagnetic [form factor], electron-proton scattering, Socio-culturale, FOS: Physical sciences, electron p: scattering, Nuclear physics, Cross section (physics), PE2_2, PE2_1, 0103 physical sciences, form factor [p], p: recoil, ddc:530, cross section: elastic scattering, 010306 general physics, PE2_3, hydrogen: target, Nuclear Physics, positron p: scattering, Ambientale, positron-proton scattering, DESY, scattering [electron p], form factor: electromagnetic, scattering [positron p], positron: beam, calorimeter: electromagnetic, p: form factor, Physics::Accelerator Physics, High Energy Physics::Experiment, spectrometer, experimental results, Lepton
Abstract

Physical review letters 126(16), 162501 (1-6) (2021). doi:10.1103/PhysRevLett.126.162501, We report the first measurement of the average of the electron-proton and positron-proton elastic scattering cross sections. This lepton charge-averaged cross section is insensitive to the leading effects of hard two-photon exchange, giving more robust access to the proton’s electromagnetic form factors. The cross section was extracted from data taken by the OLYMPUS experiment at DESY, in which alternating stored electron and positron beams were scattered from a windowless gaseous hydrogen target. Elastic scattering events were identified from the coincident detection of the scattered lepton and recoil proton in a large-acceptance toroidal spectrometer. The luminosity was determined from the rates of Møller, Bhabha, and elastic scattering in forward electromagnetic calorimeters. The data provide some selectivity between existing form factor global fits and will provide valuable constraints to future fits, Published by APS, College Park, Md.

Published
2021
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4. Clinical Outcomes and Response to Vericiguat According to Index Heart Failure Event Insights From the VICTORIA Trial

Author

Lam C, Giczewska A, Sliwa K, Edelmann F, Refsgaard J, Bocchi E, Ezekowitz J, Hernandez A, O'Connor C, Roessig L, Patel M, Pieske B, Anstrom K, Armstrong P, VICTORIA Study Grp, and MOLLAR A

Abstract

IMPORTANCE The period following heart failure hospitalization (HFH) is a vulnerable time with high rates of death or recurrent HFH. OBJECTIVE To evaluate clinical characteristics, outcomes, and treatment response to vericiguat according to prespecified index event subgroups and time from index HFH in the Vericiguat Global Study in Subjects With Heart Failure With Reduced Ejection Fraction (VICTORIA) trial. DESIGN, SETTING, AND PARTICIPANTS Analysis of an international, randomized, placebo-controlled trial. All VICTORIA patients had recent (

Published
2021

5. Vital Signs: Update on Zika Virus–Associated Birth Defects and Evaluation of All U.S. Infants with Congenital Zika Virus Exposure — U.S. Zika Pregnancy Registry, 2016

Author

Reynolds, M. R., Jones, A. M., Petersen, E. E., Lee, E. H., Rice, M. E., Bingham, A., Ellington, S. R., Evert, N., Reagan-Steiner, S., Oduyebo, T., Brown, C. M., Martin, S., Ahmad, N., Bhatnagar, J., Macdonald, J., Gould, C., Fine, A. D., Polen, K. D., Lake-Burger, H., Hillard, C. L., Hall, N., Mahsa Yazdy, Slaughter, K., Sommer, J. N., Adamski, A., Raycraft, M., Fleck-Derderian, S., Gupta, J., Newsome, K., Baez-Santiago, M., Slavinski, S., White, J. L., Moore, C. A., Shapiro-Mendoza, C. K., Petersen, L., Boyle, C., Jamieson, D. J., Meaney-Delman, D., Honein, M. A., Adair, J., Ruberto, I., Haselow, D. T., Im, L., Jilek, W., Lehmann, M. S., Olney, R., Porse, C. C., Ramstrom, K. C., Sowunmi, S., Marzec, N. S., Davis, K., Esponda-Morrison, B., Zachariah Fraser, M., O’connor, C. A., Chung, W., Richardson, F., Sexton, T., Stocks, M. E., Woldai, S., Bundek, A. M., Zambri, J., Goldberg, C., Eisenstein, L., Jackson, J., Kopit, R., Logue, T., Mendoza, R., Feldpausch, A., Graham, T., Mann, S., Park, S. Y., Carter, K. K., Potts, E. J., Stevens, T., Simonson, S., Tonzel, J. L., Davis, S., Robinson, S., Hyun, J. K., Jenkins, E. M., Piccardi, M., Reid, L. D., Dunn, J. E., Higgins, C. A., Lin, A. E., Munshi, G. S., Sandhu, K., Scotland, S. J., Soliva, S., Copeland, G., Signs, K. A., Schiffman, E., Byers, P., Hand, S., Mulgrew, C. L., Hamik, J., Koirala, S., Ludwig, L. A., Fredette, C. R., Garafalo, K., Worthington, K., Ropri, A., Ade, J. N., Alaali, Z. S., Blog, D., Brunt, S. J., Bryant, P., Burns, A. E., Carson, K., Dupuis, A. P., Sullivan-Frohm, A., Griffin, J., Hidalgo, C., Lance, L. A., Many, P. S., Naizby, B. E., Polfleit, M. J., Rahman, T., Rem, T., Robbins, A. E., Rowlands, J. V., Seaver, C., Seward, K. A., Smith, L., Sohi, I., Wester, R. E., Bush, S., Dean, A. B., Demarest, V., Dufort, E. M., Furuya, A. M., Fuschino, M., Kulas, K. E., Lamson, D. M., Lee, W. T., Limberger, R., Marchewka, M. J., Popowich, M., St George, K., Wong, S. J., Zeng, L., Glaze, V. H., Souto, M. I., Ackelsberg, J., Alex, B., Ballen, V., Baumgartner, J., Bloch, D., Clark, S., Conners, E., Cooper, H., Davidson, A., Dentinger, C., Deocharan, B., Vito, A., Fu, J., Hrusa, G., Iqbal, M., Iwamoto, M., Jones, L., Kubinson, H., Lash, M., Layton, M., Lee, C. T., Liu, D., Mcgibbon, E., Moy, M., Ngai, S., Parton, H. B., Peterson, E., Poy, J., Rakeman, J., Stoute, A., Thompson, C., Weiss, D., Westheimer, E., Winters, A., Younis, M., Chan, R. L., Cronquist, L. J., Caton, L., Lind, L., Nalluswami, K., Perella, D., Brady, D. S., Gosciminski, M., Mcauley, P., Drociuk, D., Leedom, V., Witrick, B., Bollock, J., Hartel, M. B., Lucinski, L. S., Mcdonald, M., Miller, A. M., Ponson, T. A., Price, L., Nance, A. E., Peterson, D., Cook, S., Martin, B., Oltean, H., Neary, J., Baker, M. A., Cummons, K., Bryan, K., Arnold, K. E., Arth, A. C., Bollweg, B. C., Cragan, J. D., Dawson, A. L., Denison, A. M., Dziuban, E. J., Estetter, L., Silva-Flannery, L., Free, R. J., Galang, R. R., Gary, J., Goldsmith, C. S., Green, C., Hale, G. L., Hayes, H. M., Igbinosa, I., Kelly Keating, M., Khan, S., Kim, S. Y., Lampe, M., Lewis, A., Mai, C., Martines, R. B., Miers, B., Moore, J., Muehlenbachs, A., Nahabedian, J., Panella, A., Parihar, V., Patel, M. M., Brett Rabeneck, D., Rasmussen, S. A., Ritter, J. M., Rollin, D. C., Sanders, J. H., Shieh, W. -J, Simeone, R. M., Simon, E. L., Sims, J. R., Spivey, P. J., Talley-Mcrae, H., Tshiwala, A. K., Maldeghem, K., Viens, L., Wainscott-Sargent, A., Williams, T., and Zaki, S.

Subjects
0301 basic medicine, Gerontology, medicine.medical_specialty, Microcephaly, Health (social science), Epidemiology, Health, Toxicology and Mutagenesis, Vital signs, Congenital Abnormalities, Zika virus, 03 medical and health sciences, Fetus, 0302 clinical medicine, Health Information Management, Central Nervous System Diseases, Pregnancy, Humans, Medicine, Eye Abnormalities, Neural Tube Defects, Registries, 030212 general & internal medicine, Pregnancy Complications, Infectious, Pregnancy registry, biology, Vital Signs, Zika Virus Infection, business.industry, Obstetrics, Public health, Infant, Newborn, Brain, Infant, Gestational age, Zika Virus, General Medicine, biology.organism_classification, medicine.disease, United States, 030104 developmental biology, Female, business
Abstract

Background In collaboration with state, tribal, local, and territorial health departments, CDC established the U.S. Zika Pregnancy Registry (USZPR) in early 2016 to monitor pregnant women with laboratory evidence of possible recent Zika virus infection and their infants. Methods This report includes an analysis of completed pregnancies (which include live births and pregnancy losses, regardless of gestational age) in the 50 U.S. states and the District of Columbia (DC) with laboratory evidence of possible recent Zika virus infection reported to the USZPR from January 15 to December 27, 2016. Birth defects potentially associated with Zika virus infection during pregnancy include brain abnormalities and/or microcephaly, eye abnormalities, other consequences of central nervous system dysfunction, and neural tube defects and other early brain malformations. Results During the analysis period, 1,297 pregnant women in 44 states were reported to the USZPR. Zika virus-associated birth defects were reported for 51 (5%) of the 972 fetuses/infants from completed pregnancies with laboratory evidence of possible recent Zika virus infection (95% confidence interval [CI] = 4%-7%); the proportion was higher when restricted to pregnancies with laboratory-confirmed Zika virus infection (24/250 completed pregnancies [10%, 95% CI = 7%-14%]). Birth defects were reported in 15% (95% CI = 8%-26%) of fetuses/infants of completed pregnancies with confirmed Zika virus infection in the first trimester. Among 895 liveborn infants from pregnancies with possible recent Zika virus infection, postnatal neuroimaging was reported for 221 (25%), and Zika virus testing of at least one infant specimen was reported for 585 (65%). Conclusions and implications for public health practice These findings highlight why pregnant women should avoid Zika virus exposure. Because the full clinical spectrum of congenital Zika virus infection is not yet known, all infants born to women with laboratory evidence of possible recent Zika virus infection during pregnancy should receive postnatal neuroimaging and Zika virus testing in addition to a comprehensive newborn physical exam and hearing screen. Identification and follow-up care of infants born to women with laboratory evidence of possible recent Zika virus infection during pregnancy and infants with possible congenital Zika virus infection can ensure that appropriate clinical services are available.

Published
2017
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7. Resonance Raman and lifetime studies on regioselectively deuteriated ruthenium(ii) polypyridyl complexes

Author

Browne, Wesley R., Henry, William, Passaniti, Paolo, Gandolfi, Maria Teresa, Ballardini, Roberto, O’Connor, Christine M., Brady, Clare, Coates, Colin G., Vos, Johannes G., McGarvey, John J., M. O'Connor, C., and Synthetic Organic Chemistry

Subjects
Luminescence, Pyrazine, Photochemistry, Pyridines, Molecular Conformation, PH CONTROL, Infrared spectroscopy, chemistry.chemical_element, Electrons, Spectrum Analysis, Raman, Sensitivity and Specificity, VIBRATIONAL SPECTROSCOPY, Ruthenium, (3)MLCT STATES, symbols.namesake, chemistry.chemical_compound, TRIS(BIPYRIDINE)RUTHENIUM(II), TRANSFER EXCITED-STATES, Ultrafast laser spectroscopy, Electrochemistry, Organometallic Compounds, Physical and Theoretical Chemistry, MONONUCLEAR, Spectroscopy, Temperature, RU(II), Stereoisomerism, LOCALIZATION, Deuterium, Resonance (chemistry), chemistry, PHOTOPHYSICAL PROPERTIES, Excited state, symbols, Physical chemistry, LIGANDS, Raman spectroscopy
Abstract

Two series of ruthenium(II) polypyridyl complexes [Ru(bipy)(2)(phpytr)](+) and [Ru(bipy)(2)(phpztr)](+) (where Hphpytr = 2-(5-phenyl-1H-[1,2,4]triazol-3-yl)-pyridine and Hphpztr = 2-(5-phenyl-1H-[1,2,4]triazol-3-yl)-pyrazine) are examined by electrochemistry, UV/Vis, emission, resonance Raman, transient resonance Raman and transient absorption spectroscopy, in order to obtain a more comprehensive understanding of their excited state electronic properties. The interpretation of the results obtained is facilitated by the availability of several isotopologues of each of the complexes examined. For the pyridine-1,2,4-triazolato based complex the lowest emissive excited state is exclusively bipy based, however, for the pyrazine based complexes excited state localisation on particular ligands shows considerable solvent and pH dependency.

Published
2007
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11. Albumin Priming Does Not Prolong Hemofilter Life

Author

Seal Pf, Voss Al, O'Connor C, and Reeves Jh

Subjects
medicine.medical_specialty, medicine.diagnostic_test, biology, business.industry, medicine.medical_treatment, Biomedical Engineering, Biophysics, Serum albumin, Bioengineering, Liter, General Medicine, Heparin, medicine.disease, Surgery, Biomaterials, Log-rank test, Anesthesia, medicine, Coagulopathy, biology.protein, Hemodialysis, business, Saline, Partial thromboplastin time, medicine.drug
Abstract

The hypothesis was tested that prepriming a hemofilter and lines with heparinized human albumin (NSA) instead of heparinized saline (NS) increases filter survival time. In a university affiliated intensive care unit, all patients were eligible who required continuous venovenous hemodiafiltration and who did not have pre-existing coagulopathy or contraindications to heparin. New hemofilters were randomized to priming with 2 liters NS or 1 liter NS followed by 500ml NSA. The prime was recirculated for at least 30 minutes before connection to the patient. Anticoagulation was tightly controlled, aiming for a patient activated partial thromboplastin time (APTT) of 60 seconds. Survival analysis was used to compare filter life. Elective discontinuation (e.g., for surgery) were treated as censored data. A total of 91 hemofilters were used in 40 patients during 9 months: 45 randomized to NS, and 46 to NSA. Of these, 57 hemofilters were used until spontaneous failure, 28 NS and 29 NSA; 34 hemofilters were electively discontinued, 17 in each group. Anticoagulation was identical in both groups; the mean APTT value (+/- SE) was 58.2 seconds (+/- 3.1) for NS and 58.0 seconds (+/- 2.8) for NSA (p > 0.9 unpaired t-test). Platelet counts were very similar at 170 x 10(9) (+/- 21.8) for NS and 181 x 10(9) (+/- 23.7) for NSA (p = 0.74 unpaired t-test). There was no significant difference in the filter life between the two groups. For NS, median filter life was 37.8 hours (range 0.6-120); for NSA, median filter life was 45.4 hours (range 2.5-109; p = 0.998 log rank). The power to detect a 50% improvement in filter life was > 90%. Based on this data, the use of albumin priming as an aid to increased hemofilter life can not be recommended.

Published
1997
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12. Measurement of Muon Neutrino Quasielastic Scattering on a Hydrocarbon Target atEν∼3.5 GeV

Author

The MINERvA collaboration, Fiorentini, G. A., Schmitz, D. W., Rodrigues, P. A., Aliaga, L., Altinok, O., Baldin, B., Baumbaugh, A., Bodek, A., Boehnlein, D., Boyd, S., Bradford, R., Brooks, W. K., Budd, H., Butkevich, A., Caicedo, D. A. Martinez, Castromonte, C. M., Christy, M. E., Chung, H., Chvojka, J., Clark, M., da Motta, H., Damiani, D. S., Danko, I., Datta, M., Day, M., DeMaat, R., Devan, J., Draeger, E., Dytman, S. A., Díaz, G. A., Eberly, B., Edmondson, D. A., Felix, J., Fitzpatrick, T., Fields, L., Gago, A. M., Gallagher, H., George, C. A., Gielata, J. A., Gingu, C., Gobbi, B., Gran, R., Grossman, N., Hanson, J., Harris, D. A., Heaton, J., Higuera, A., Howley, I. J., Hurtado, K., Jerkins, M., Kafka, T., Kaisen, J., Kanter, M. O., Keppel, C. E., Kilmer, J., Kordosky, M., Krajeski, A. H., Kulagin, S. A., Le, T., Lee, H., Leister, A. G., Locke, G., Maggi, G., Maher, E., Manly, S., Mann, W. A., Marshall, C. M., McFarland, K. S., McGivern, C. L., McGowan, A. M., Mislivec, A., Morfń, J. G., Mousseau, J., Naples, D., Nelson, J. K., Niculescu, G., Niculescu, I., Ochoa, N., O'Connor, C. D., Olsen, J., Osmanov, B., Osta, J., Palomino, J. L., Paolone, V., Park, J., Patrick, C. E., Perdue, G. N., Peña, C., Rakotondravohitra, L., Ransome, R. D., Ray, H., Ren, L., Rude, C., Sassin, K. E., Schellman, H., Schneider, R. M., Schulte, E. C., Simon, C., Snider, F. D., Snyder, M. C., Sobczyk, J. T., Salinas, C. J. Solano, Tagg, N., Tan, W., Tice, B. G., Tzanakos, G., Velásquez, J. P., Walding, J., Walton, T., Wolcott, J., Wolthuis, B. A., Woodward, N., Zavala, G., Zeng, H. B., Zhang, D., Zhu, L. Y., and Ziemer, B. P.

Subjects
Physics, Elastic scattering, Physics::Instrumentation and Detectors, 010308 nuclear & particles physics, General Physics and Astronomy, 01 natural sciences, 7. Clean energy, NuMI, High Energy Physics - Experiment, Nuclear physics, 0103 physical sciences, Content (measure theory), High Energy Physics::Experiment, Muon neutrino, Fermilab, 010306 general physics, Fermi gas, Nucleon, Nuclear Experiment, Energy (signal processing)
Abstract

We report a study of muon neutrino charged-current quasi-elastic events in the segmented scintillator inner tracker of the MINERvA experiment running in the NuMI neutrino beam at Fermilab. The events were selected by requiring a {\mu}^- and low calorimetric recoil energy separated from the interaction vertex. We measure the flux-averaged differential cross-section, d{\sigma}/dQ^2, and study the low energy particle content of the final state. Deviations are found between the measured d{\sigma}/dQ^2 and the expectations of a model of independent nucleons in a relativistic Fermi gas. We also observe an excess of energy near the vertex consistent with multiple protons in the final state., Comment: 7 pages, 5 figures. Added correlation between neutrino and anti-neutrino result in ancillary files (CSV)

Published
2013
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13. Measurement of Muon Antineutrino Quasi-Elastic Scattering on a Hydrocarbon Target at E_�� ~ 3.5 GeV

Author

The MINERvA Collaboration, Fields, L., Chvojka, J., Aliaga, L., Altinok, O., Baldin, B., Baumbaugh, A., Bodek, A., Boehnlein, D., Boyd, S., Bradford, R., Brooks, W. K., Budd, H., Butkevich, A., Caicedo, D. A. Martinez, Castromonte, C. M., Christy, M. E., Chung, H., Clark, M., da Motta, H., Damiani, D. S., Danko, I., Datta, M., Day, M., DeMaat, R., Devan, J., Draeger, E., Dytman, S. A., D��az, G. A., Eberly, B., Edmondson, D. A., Felix, J., Fitzpatrick, T., Fiorentini, G. A., Gago, A. M., Gallagher, H., George, C. A., Gielata, J. A., Gingu, C., Gobbi, B., Gran, R., Grossman, N., Hanson, J., Harris, D. A., Heaton, J., Higuera, A., Howley, I. J., Hurtado, K., Jerkins, M., Kafka, T., Kaisen, J., Kanter, M. O., Keppel, C. E., Kilmer, J., Kordosky, M., Krajeski, A. H., Kulagin, S. A., Le, T., Lee, H., Leister, A. G., Locke, G., Maggi, G., Maher, E., Manly, S., Mann, W. A., Marshall, C. M., McFarland, K. S., McGivern, C. L., McGowan, A. M., Mislivec, A., Morf��n, J. G., Mousseau, J., Naples, D., Nelson, J. K., Niculescu, G., Niculescu, I., Ochoa, N., O'Connor, C. D., Olsen, J., Osmanov, B., Osta, J., Palomino, J. L., Paolone, V., Park, J., Patrick, C. E., Perdue, G. N., Pe��a, C., Rakotondravohitra, L., Ransome, R. D., Ray, H., Ren, L., Rodrigues, P. A., Rude, C., Sassin, K. E., Schellman, H., Schmitz, D. W., Schneider, R. M., Schulte, E. C., Simon, C., Snider, F. D., Snyder, M. C., Sobczyk, J. T., Salinas, C. J. Solano, Tagg, N., Tan, W., Tice, B. G., Tzanakos, G., Vel��squez, J. P., Walding, J., Walton, T., Wolcott, J., Wolthuis, B. A., Woodward, N., Zavala, G., Zeng, H. B., Zhang, D., Zhu, L. Y., and Ziemer, B. P.

Subjects
High Energy Physics - Experiment (hep-ex), Physics::Instrumentation and Detectors, FOS: Physical sciences, High Energy Physics::Experiment, Nuclear Experiment (nucl-ex), Nuclear Experiment
Abstract

We have isolated muon anti-neutrino charged-current quasi-elastic interactions occurring in the segmented scintillator tracking region of the MINERvA detector running in the NuMI neutrino beam at Fermilab. We measure the flux-averaged differential cross-section, d��/dQ^2, and compare to several theoretical models of quasi-elastic scattering. Good agreement is obtained with a model where the nucleon axial mass, M_A, is set to 0.99 GeV/c^2 but the nucleon vector form factors are modified to account for the observed enhancement, relative to the free nucleon case, of the cross-section for the exchange of transversely polarized photons in electron-nucleus scattering. Our data at higher Q^2 favor this interpretation over an alternative in which the axial mass is increased., 8 pages, 5 figures. Added correlation between neutrino and anti-neutrino results in ancillary text files (CSV)

Published
2013
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14. Measurement of Muon Neutrino Quasi-Elastic Scattering on a Hydrocarbon Target at E_�� ~ 3.5 GeV

Author

The MINERvA Collaboration, Fiorentini, G. A., Schmitz, D. W., Rodrigues, P. A., Aliaga, L., Altinok, O., Baldin, B., Baumbaugh, A., Bodek, A., Boehnlein, D., Boyd, S., Bradford, R., Brooks, W. K., Budd, H., Butkevich, A., Caicedo, D. A. Martinez, Castromonte, C. M., Christy, M. E., Chung, H., Chvojka, J., Clark, M., da Motta, H., Damiani, D. S., Danko, I., Datta, M., Day, M., DeMaat, R., Devan, J., Draeger, E., Dytman, S. A., D��az, G. A., Eberly, B., Edmondson, D. A., Felix, J., Fitzpatrick, T., Fields, L., Gago, A. M., Gallagher, H., George, C. A., Gielata, J. A., Gingu, C., Gobbi, B., Gran, R., Grossman, N., Hanson, J., Harris, D. A., Heaton, J., Higuera, A., Howley, I. J., Hurtado, K., Jerkins, M., Kafka, T., Kaisen, J., Kanter, M. O., Keppel, C. E., Kilmer, J., Kordosky, M., Krajeski, A. H., Kulagin, S. A., Le, T., Lee, H., Leister, A. G., Locke, G., Maggi, G., Maher, E., Manly, S., Mann, W. A., Marshall, C. M., McFarland, K. S., McGivern, C. L., McGowan, A. M., Mislivec, A., Morf��, J. G., Mousseau, J., Naples, D., Nelson, J. K., Niculescu, G., Niculescu, I., Ochoa, N., O'Connor, C. D., Olsen, J., Osmanov, B., Osta, J., Palomino, J. L., Paolone, V., Park, J., Patrick, C. E., Perdue, G. N., Pe��a, C., Rakotondravohitra, L., Ransome, R. D., Ray, H., Ren, L., Rude, C., Sassin, K. E., Schellman, H., Schneider, R. M., Schulte, E. C., Simon, C., Snider, F. D., Snyder, M. C., Sobczyk, J. T., Salinas, C. J. Solano, Tagg, N., Tan, W., Tice, B. G., Tzanakos, G., Vel��squez, J. P., Walding, J., Walton, T., Wolcott, J., Wolthuis, B. A., Woodward, N., Zavala, G., Zeng, H. B., Zhang, D., Zhu, L. Y., and Ziemer, B. P.

Subjects
High Energy Physics - Experiment (hep-ex), Physics::Instrumentation and Detectors, FOS: Physical sciences, High Energy Physics::Experiment, Nuclear Experiment (nucl-ex)
Abstract

We report a study of muon neutrino charged-current quasi-elastic events in the segmented scintillator inner tracker of the MINERvA experiment running in the NuMI neutrino beam at Fermilab. The events were selected by requiring a ��^- and low calorimetric recoil energy separated from the interaction vertex. We measure the flux-averaged differential cross-section, d��/dQ^2, and study the low energy particle content of the final state. Deviations are found between the measured d��/dQ^2 and the expectations of a model of independent nucleons in a relativistic Fermi gas. We also observe an excess of energy near the vertex consistent with multiple protons in the final state., 7 pages, 5 figures. Added correlation between neutrino and anti-neutrino result in ancillary files (CSV)

Published
2013
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15. DCE-MRI biomarkers of tumour heterogeneity predict CRC liver metastasis shrinkage following bevacizumab and FOLFOX-6

Author

J P B O'Connor, C J Rose, A Jackson, Y Watson, S Cheung, F Maders, B J Whitcher, C Roberts, G A Buonaccorsi, G Thompson, A R Clamp, G C Jayson and G J M Parker

Abstract

Background: There is limited evidence that imaging biomarkers can predict subsequent response to therapy. Such prognostic and/or predictive biomarkers would facilitate development of personalised medicine. We hypothesised that pre-treatment measurement of the heterogeneity of tumour vascular enhancement could predict clinical outcome following combination anti-angiogenic and cytotoxic chemotherapy in colorectal cancer (CRC) liver metastases.Methods: Ten patients with 26 CRC liver metastases had two dynamic contrast-enhanced MRI (DCE-MRI) examinations before starting first-line bevacizumab and FOLFOX-6. Pre-treatment biomarkers of tumour microvasculature were computed and a regression analysis was performed against the post-treatment change in tumour volume after five cycles of therapy. The ability of the resulting linear model to predict tumour shrinkage was evaluated using leave-one-out validation. Robustness to inter-visit variation was investigated using data from a second baseline scan.Results: In all, 86% of the variance in post-treatment tumour shrinkage was explained by the median extravascular extracellular volume (ve), tumour enhancing fraction (EF), and microvascular uniformity (assessed with the fractal measure box dimension, d0) (R2=0.86, P

Published
2011

16. Coronary-artery bypass surgery in patients with left ventricular dysfunction

Author

Velazquez, E, Lee, K, Deja, Ma:, J, A, Sopko, G, Marchenko, A, Ali, I, Pohost, G, Gradinac, S, Abraham, W, Yii, M, Prabhakaran, D, Szwed, H, Ferrazzi, P, Petrie, M, O'Connor, C, Panchavinnin, P, She, L, Bonow, R, Rankin, G, Jones, R, Rouleau, J, Cherniavsky, A, Romanov, A, Wos, S, Deja, M, Golba, K, Malinowski, M, Kosevic, D, Vukovic, M, Djokovic, L, Krzeminska Pakula, M, Jaszewski, R, Drozdz, J, Chrzanowski, L, Rajda, M, Howlett, J, Macfarlane, M, Jain, A, Shah, H, Rakshak, D, Saxena, A, Zembala, M, Przybylski, R, Kukulski, T, Wasilewski, J, Wiechowski, S, Brykczynski, M, Kurowski, M, Mokrzycki, K, Sadowski, J, Kapelak, B, Sobczyk, D, Plicner, D, Wrobel, K, Piegas, L, Paulista, P, Farsky, P, Veiga Kantorowitz, C, Sadowski, Z, Juraszynski, Z, Dabrowski, R, Rogowski, J, Pawlaczyk, R, Rynkiewicz, A, Betlejewski, P, Siepe, M, Geibel Zehender, A, Cuerten, C, Higgins, R, Crestanello, J, Binkley, P, Jones, D, Sun, B, Smith, P, Milano, C, Adams, P, Hill, J, Beaver, T, Leach, D, Airan, B, Das, S, Prior, D, Mack, J, Rao, V, Iwanochko, R, Renton, J, Phuangkaew, N, Bochenek, A, Krejca, M, Trusz Gluza, M, Wita, K, Gavazzi, A, Senni, M, Natarajan, S, Padmanabhan, C, Racine, N, Bouchard, D, Ducharme, A, Brown, H, Alotti, N, Lupkovics, G, Kumar, S, Agarwal, S, Sinha, N, Rai, H, Andersson, B, Janssen, A, Lamy, A, Demers, C, Rizzo, T, Doenst, T, Garbade, J, Thiele, H, Richter, M, Murday, A, Shaw, M, Raju, K, Mannam, G, Reddy, G, Rao, K, Nicolau, J, Stolf, N, Vieira, A, Chua, Y, Lim, C, Kwok, B, Gan, Y, Cleland, J, Cale, A, Thackray, S, Lammiman, M, Michler, R, Swayze, R, Maurer, G, Grimm, M, Lang, I, Adlbrecht, C, Daly, R, Rodeheffer, R, Nelson, S, Larbalestier, R, Wang, X, Haddad, H, Hendry, P, Donaldson, J, Menicanti, L, Di Donato, M, Castelvecchio, S, Sirvydis, V, Voluckiene, E, Di Benedetto, G, Attisano, T, Favaloro, R, Favaloro, L, Diez, M, Riccitelli, M, Picone, V, Koslowski, P, Gaito, M, Al mohammad, A, Braidley, P, Steele, H, Nawarawong, W, Woragidpoonpol, S, Kuanprasert, S, Mekara, W, Kon, N, Hammon, J, Wells, G, Tilley, W, Drazner, M, Di Maio, M, Peschka, S, Pasquale, D, Knight, C, J, Aylward, P, Thomas, C, Gullestad, L, Sorensen, G, Kaul, U, Gupta, R, Schmedtje, Jj, Arnold, S, Wilson, V, Grayburn, P, Hamman, B, Hebeler, R, Aston, S, Birjiniuk, V, Harrington, M, Dupree, C, Sheridan, B, Schuler, C, Helou, J, Denis, I, Bigalli, D, Gutierrez, F, Russo, N, Batlle, C, White, H, Alison, P, Stewart, R, Borthwick, L, Philippides, G, Shemin, R, Fitzgerald, C, Dagenais, F, Dussault, G, Kamath, P, Busmann, C, Ferrari, G, Botto, M, Horkay, F, Hartyanszky, I, Bartha, E, Simor, T, Papp, L, Toth, L, Varga Szemes, A, Szekely, L, Keltai, M, Edes, I, Szathmarine, V, Yakub, M, Sarip, S, Maitland, A, Isaac, D, Holland, M, Bogats, G, Csepregi, L, Maia, L, Soares, M, Mouco, O, Souza, A, da Rocha, A, Brito, J, Pitella, F, Camara, A, Horowitz, J, Knight, J, Rose, J, Mcrae, Rj, Geiss, D, Clemson, B, Pierson, M, Kron, I, Kern, J, Bergin, J, Phillips, J, Rich, J, Herre, J, Pine, L, Chin, D, Spyt, T, Logtens, E, Amuchastegui, L, Bracco, D, Ruengsakulrach, P, Pitiguagool, V, Sukhum, P, Srinualta, D, Hayward, C, Herrera, C, Zimmermann, R, Patterson, G, Stephens, W, Dignan, R, French, J, Sequalino, N, Vaishnav, S, Panda, R, Chavan, A, Benetis, R, Jankauskiene, L, Kalil, R, Nesralla, I, Santos, M, de Moraes, M, Friedrich, I, Buerke, M, Paraforos, A, Konda, S, Leone, C, Murphy, E, Ravichandran, P, Avalos, K, Hetzer, R, Knosalla, C, Hoffmann, K, Landolfo, K, Landolfo, C, Park, M, Chiariello, L, Nardi, P, Stapleton, D, Hoey, K, Hasaniya, N, Wang, N, Bijou, R, Naka, Y, Ascheim, D, Mikati, I, Arnold, M, Mckenzie, N, Smith, J, Gheorghiade, M, Fullerton, D, Roberts, L, Carson, P, Miller, A, Pina, I, Selzman, C, Wertheimer, J, Goldstein, S, Cohn, F, Hlatky, M, Kennedy, K, Rankin, S, Robbins, R, Zaret, B, Barfield, T, Desvigne Nickens, P, Oh, J, Panza, J, Apte, P, Doyle, M, Forder, J, Ocon, M, Pai, R, Reddy, V, Santos, N, Tripathi, R, Varadarajan, P, Pellikka, P, Miller, Fj, Lin, G, Borgeson, D, Ommen, S, Casaclang Verzosa, G, Miller, D, Springer, R, Blahnik, F, Manahan, B, Welper, J, Wiste, H, Mark, D, Anstrom, K, Baloch, K, Burnette, A, Cowper, P, Davidson Ray, N, Drew, L, Harding, T, Hunt, V, Knight, D, Patterson, A, Redick, T, Sanderford, B, Feldman, A, Bristow, M, Chan, T, Maisel, A, Mann, D, Mcnamara, D, Holly, T, Berman, D, Leonard, S, Helmer, D, Woods, M, Mcnulty, M, Asch, F, Rumsey, M, Bieganski, S, Roberts, B, Handschumacher, M, Mccormick, A, Albright, J, Dandridge, R, Rittenhouse, L, Wagstaff, D, Williams, M, Bailey, D, Glover, D, Parrish, L, Wakeley, N, Jackson, V, Nicholson, B, Mcdaniel, A, Al Khalidi, H, Greene, D, and Moore, V

Subjects
Male, medicine.medical_specialty, Coronary Artery Disease, Kaplan-Meier Estimate, 030204 cardiovascular system & hematology, law.invention, Coronary artery disease, 03 medical and health sciences, Coronary artery bypass surgery, Ventricular Dysfunction, Left, 0302 clinical medicine, Randomized controlled trial, law, Internal medicine, medicine, Clinical endpoint, Humans, 03.02. Klinikai orvostan, cardiovascular diseases, 030212 general & internal medicine, Coronary Artery Bypass, Aged, Proportional Hazards Models, Heart Failure, Intention-to-treat analysis, Proportional hazards model, business.industry, Hazard ratio, Settore MED/23 - Chirurgia Cardiaca, General Medicine, Middle Aged, medicine.disease, Combined Modality Therapy, 3. Good health, Surgery, Intention to Treat Analysis, Hospitalization, surgical procedures, operative, Cardiovascular Diseases, Heart failure, Cardiology, Female, business
Abstract

The role of coronary-artery bypass grafting (CABG) in the treatment of patients with coronary artery disease and heart failure has not been clearly established.Between July 2002 and May 2007, a total of 1212 patients with an ejection fraction of 35% or less and coronary artery disease amenable to CABG were randomly assigned to medical therapy alone (602 patients) or medical therapy plus CABG (610 patients). The primary outcome was the rate of death from any cause. Major secondary outcomes included the rates of death from cardiovascular causes and of death from any cause or hospitalization for cardiovascular causes.The primary outcome occurred in 244 patients (41%) in the medical-therapy group and 218 (36%) in the CABG group (hazard ratio with CABG, 0.86; 95% confidence interval [CI], 0.72 to 1.04; P=0.12). A total of 201 patients (33%) in the medical-therapy group and 168 (28%) in the CABG group died from an adjudicated cardiovascular cause (hazard ratio with CABG, 0.81; 95% CI, 0.66 to 1.00; P=0.05). Death from any cause or hospitalization for cardiovascular causes occurred in 411 patients (68%) in the medical-therapy group and 351 (58%) in the CABG group (hazard ratio with CABG, 0.74; 95% CI, 0.64 to 0.85; P

Published
2011

18. Metaproteomic and metagenomic analyses of defined oceanic microbial populations using microwave cell fixation and flow cytometric sorting

Author

Mary, Isabelle, Oliver, Anna, Skipp, Paul, Holland, Ross, Topping, Juliette, Tarran, Glen, Scanlan, David J, O'Connor, C David, Whiteley, Andrew S, Burkill, Peter H, Zubkov, Mikhail V, National Oceanography Centre (NOC), Laboratoire Microorganismes : Génome et Environnement (LMGE), Université Blaise Pascal - Clermont-Ferrand 2 (UBP)-Université d'Auvergne - Clermont-Ferrand I (UdA)-Centre National de la Recherche Scientifique (CNRS), Molecular Microbial Ecology Section, Biodiversity and Ecosystem Function Group-CEH-Oxford, School of Biological Sciences, University of Southampton, Plymouth Marine Laboratory, Department of Biological Sciences [Coventry], and University of Warwick [Coventry]

Subjects
[SDV.EE]Life Sciences [q-bio]/Ecology, environment, Proteomics, Synechococcus, Tandem Mass Spectrometry, Oceans and Seas, fungi, Feasibility Studies, Metagenomics, Flow Cytometry, Microwaves, Genome, Bacterial, Chromatography, Liquid
Abstract

International audience; A major obstacle in the molecular investigation of natural, especially oceanic, microbial cells is their adequate preservation for further land-based molecular analyses. Here, we examined the use of microwaves for cell fixation before high-speed flow cytometric sorting to define the metaproteomes and metagenomes of key microbial populations. The microwave fixation procedure was established using cultures of Synechococcus cyanobacteria, the photosynthetic eukaryote Micromonas pusilla and the gammaproteobacterium Halomonas variabilis. Shotgun proteomic analyses showed that the profile of microwave-fixed and -unfixed Synechococcus sp. WH8102 cells was the same, and hence proteome identification of microwave-fixed sorted cells by nanoLC-MS/MS is possible. Microwave-fixed flow-sorted Synechococcus cells can also be successfully used for whole-genome amplification and fosmid library construction. We then carried out successful metaproteomic and metagenomic analyses of microwave-fixed Synechococcus cells flow sorted from concentrates of microbial cells, collected in the North Atlantic Ocean. Thus, the microwave fixation procedure developed appears to be useful for molecular studies of microbial populations in aquatic ecosystems.

Published
2010
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20. Dynamic transverse susceptibility in Au-Fe-Au 'nano-onions'

Author

Srikanth, H., Carpenter, E. E., and O'Connor, C. J.

Subjects
Condensed Matter - Materials Science, Materials Science (cond-mat.mtrl-sci), FOS: Physical sciences
Abstract

A precision radio-frequency (RF) transverse modulation technique based on a resonant tunnel diode oscillator (TDO) has been used to study the dynamic susceptibility in novel ring-shaped single domain Fe nanoparticles synthesized using reverse-micelle chemistry. Hysteresis loops measured using a SQUID magnetometer indicate a large coercivity (Hc = 400Oe) below the blocking temperature (TB ~52K). The dynamic susceptibility shows remarkable consistency with the M-H data and exhibits peaks at characteristic anisotropy fields. Overall, these RF experiments are well suited to probe the magnetic anisotropy in nanophase materials., Comment: PDF file, 4 pages, 5 figures, 1 color figure

Published
1999
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21. Diagnosis of Enterobacteriaceae in the Hospital Laboratory

Author

O'Connor C, Viola M. Young, and Douglas Gw

Subjects
Bacteriological Techniques, Carboxy-lyases, Arginine, Clinical Laboratory Techniques, Lysine, Deamination, Potassium cyanide, General Medicine, Biology, biology.organism_classification, Enterobacteriaceae, Microbiology, chemistry.chemical_compound, Biochemistry, chemistry, Urea, Humans, Feces
Published
1966
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22. Evaluation of placental and fetal tissue specimens for Zika virus infection — 50 states and district of Columbia, January-December, 2016

Author

Reagan-Steiner, S., Simeone, R., Simon, E., Bhatnagar, J., Oduyebo, T., Free, R., Denison, A. M., Rabeneck, D. B., Ellington, S., Petersen, E., Gary, J., Hale, G., Keating, M. K., Martines, R. B., Muehlenbachs, A., Ritter, J., Lee, E., Davidson, A., Conners, E., Scotland, S., Sandhu, K., Bingham, A., Kassens, E., Smith, L., St George, K., Ahmad, N., Tanner, M., Beavers, S., Miers, B., Maldeghem, K., Khan, S., Rabe, I., Gould, C., Meaney-Delman, D., Honein, M. A., Shieh, W. -J, Jamieson, D. J., Fischer, M., Zaki, S. R., Kretschmer, M., Tarter, K., Yaglom, H., Alhajmohammad, S., Chhabra, D., Jilek, W., Madala, M., Messenger, S., Porse, C. C., Salas, M., Singh, D., Skallet, S., Sowunmi, S., Marzec, N. S., Davis, K., Esponda-Morrison, B., Fraser, M. Z., O’connor, C. A., Chung, W. M., Richardson, F., Stocks, M. E., Bundek, A. M., Zambri, M. L., Allen, A., Etienne, M. K., Jackson, J., Landis, V., Logue, T., Muse, N., Prieto, J., Rojas, M., Feldpausch, A., Graham, T., Mann, S., Park, S. Y., Freeman, D., Potts, E. J., Stevens, T., Simonson, S., Tonzel, J. L., Davis, S., Robinson, S., Hyun, J. K., Jenkins, E. M., Brown, C., Soliva, S., Schiffman, E., Byers, P., Hand, S., Mulgrew, C. L., Hamik, J., Koirala, S., Ludwig, E., Fredette, C. R., Mathewson, A. A., Garafalo, K., Worthington, K., Ropri, A., Bloch, D., Clark, S., Cooper, H., Fine, A. D., Hrusa, G., Iwamoto, M., Kubinson, H., Lee, C. T., Slavinski, S., Wilson, E., Winters, A., Yang, D. Y., Ade, J. N., Alaali, Z., Alvarez, K., Backenson, P. B., Blog, D., Dean, A., Dufort, E., Furuya, A. M., Fuschino, M., Hull, R., Kleabonas, M., Kulas, K., Kurpiel, P., Lance, L. A., Leak, E., Limberger, R. J., Ostrowski, S., Polfleit, M., Robbins, A., Rowlands, J. V., Sohi, I., Sommer, J. N., White, J., Wiley, D., Zeng, L., Chan, R. L., Macfarquhar, J., Cronquist, L., Lind, L., Nalluswami, K., Perella, D., Brady, D. S., Gosciminski, M., Mcauley, P., Teevan, B. E., Drociuk, D., Leedom, V., Witrick, B., Bollock, J., Kightlinger, L., Hartel, M. B., Lucinski, L. S., Mcdonald, M., Miller, A. M., Ponson, T. A., Price, L., Broussard, K., Nance, A. E., Peterson, D., Martin, B., Browne, S., Griffin-Thomas, L. A., Macdonald, J. O., Neary, J., Oltean, H., Adamski, A., Baez-Santiago, M., Bollweg, B. C., Cragan, J. D., Ermias, Y., Estetter, L. B. C., Fleck-Derderian, S., Goldsmith, C. S., Groenewold, M. R., Hayes, H., Igbinosa, I., Jenkinson, T. G., Jones, A. M., Lewis, A., Moore, C. A., Newsome, K. B., Parihar, V., Patel, M. M., Paulino, A., Rasmussen, S. A., Raycraft, M., Reynolds, M. R., Rollin, D. C., Sanders, J. H., Shapiro-Mendoza, C., Silva-Flannery, L., Spivey, P., Tshiwala, A. K., Williams, T. R., Bower, W. A., Davlantes, E., Forward, T. R., Fukunaga, R., Hines, J., Hu, S. S., Leung, J., Lewis, L., Martin, S., Mcnamara, L., Omura, J. D., Robinson, C. L., Schmit, K., Self, J. L., Shah, M., Straily, A., Dyne, E. A., Vu, M., and Williams, C.

24. Predictive Value of Selected Admission Criteria for Graduate Nursing Education

Author

Andersen Le, Colby Bk, Ouimet Km, Ainslie Bs, Meserve Kp, Hoffman Ma, and O'Connor C

Subjects
medicine.medical_specialty, business.industry, Family medicine, Community health, Grade point, Marital status, Medicine, Degree of association, Nurse education, business, Predictive value, General Nursing, Nursing Outcomes Classification
Abstract

To determine if there are admission criteria that predict success in graduate nursing education, an investigation was conducted of 193 graduates who had successfully completed the masters nursing program at a private eastern university. Admission criteria and other variables chosen were nursing, nonnursing, and cumulative undergraduate grade point averages (GPAs); verbal, quantitative, and combined Graduate Record Examination (GRE) scores; age at entrance; number of years intervening between attainment of the bachelors and completion of the masters degree; and, number of years intervening between the basic nursing education and the completion of the masters degree. Each variable was correlated with masters GPA for degree of association. Pearson's coefficient of correlation was used to analyze the data. Subgroups were analyzed in relation to the chosen area of clinical concentration: community health, psychiatric, medical-surgical, and maternal-child nursing; basic nursing education: diploma or generic baccalaureate; and, marital status: single or married. Nursing, nonnursing, and cumulative undergraduate GPAs were found to be weakly associated with the masters GPA except for the psychiatric subgroup which showed a moderate correlation between the cumulative under-graduate and the masters GPAs. Weak associations were found between verbal, quantitative, and total GRE scores and the masters GPA, with two exceptions: for psychiatric and community health subgroups there were moderate degrees of association between verbal GRE scores and the masters GPA. Age was not an effective criterion for predicting degree of success in the program. Both measures of intervening years were found to be weakly associated with the masters GPA.

Published
1976
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25. Developing therapies for heart failure with preserved ejection fraction: current state and future directions

Author

Javed, Butler, Gregg C, Fonarow, Michael R, Zile, Carolyn S, Lam, Lothar, Roessig, Erik B, Schelbert, Sanjiv J, Shah, Ali, Ahmed, Robert O, Bonow, John G F, Cleland, Robert J, Cody, Ovidiu, Chioncel, Sean P, Collins, Preston, Dunnmon, Gerasimos, Filippatos, Martin P, Lefkowitz, Catherine N, Marti, John J, McMurray, Frank, Misselwitz, Savina, Nodari, Christopher, O'Connor, Marc A, Pfeffer, Burkert, Pieske, Bertram, Pitt, Giuseppe, Rosano, Hani N, Sabbah, Michele, Senni, Scott D, Solomon, Norman, Stockbridge, John R, Teerlink, Vasiliki V, Georgiopoulou, Mihai, Gheorghiade, Butler, J, Fonarow, G, Zile, M, Lam, C, Roessig, L, Schelbert, E, Shah, S, Ahmed, A, Bonow, R, Cleland, J, Cody, R, Chioncel, O, Collins, S, Dunnmon, P, Filippatos, G, Lefkowitz, M, Marti, C, Mcmurray, J, Misselwitz, F, Nodari, S, O'Connor, C, Pfeffer, M, Pieske, B, Pitt, B, Rosano, G, Sabbah, H, Senni, M, Solomon, S, Stockbridge, N, Teerlink, J, Georgiopoulou, V, and Gheorghiade, M

Subjects
Prognosi, Systole, Hypertension, Pulmonary, Left, heart failure, Cardiorespiratory Medicine and Haematology, Cardiovascular, Ventricular Function, Left, Article, Ventricular Dysfunction, Left, Vascular Stiffness, Diastole, Ventricular Dysfunction, epidemiology, preserved ejection fraction, prognosis, treatment, Animals, Clinical Trials as Topic, Disease Models, Animal, Echocardiography, Forecasting, Heart Atria, Heart Failure, Humans, Stroke Volume, Treatment Outcome, Ventricular Function, Animal, Pulmonary, Heart Disease, Hypertension, Disease Models
Abstract

The burden of heart failure with preserved ejection fraction (HFpEF) is considerable and is projected to worsen. To date, there are no approved therapies available for reducing mortality or hospitalizations for these patients. The pathophysiology of HFpEF is complex and includes alterations in cardiac structure and function, systemic and pulmonary vascular abnormalities, end-organ involvement, and comorbidities. There remain major gaps in our understanding of HFpEF pathophysiology. To facilitate a discussion of how to proceed effectively in future with development of therapies for HFpEF, a meeting was facilitated by the Food and Drug Administration and included representatives from academia, industry, and regulatory agencies. This document summarizes the proceedings from this meeting.

Published
2014

26. Prognosis and mechanism of death in treated heart failure: data from the placebo arm of Val-HeFT

Author

Peter E. Carson, Lynne W. Stevenson, Jay N. Cohn, A Volpi, Marino Scherillo, Cristina Opasich, Ileana L. Piña, Gianfranco Sinagra, Felix E. Tristani, Christopher M. O'Connor, Cohn, Jn, Carson, Pe, O'Connor, C, Opasich, C, Pina, Il, Scherillo, M, Sinagra, Gianfranco, WARNER STEVENSON, L, Tristani, Fe, and Volpi, A.

Subjects
Male, medicine.medical_specialty, Patient Dropouts, Adrenergic beta-Antagonists, Angiotensin-Converting Enzyme Inhibitors, Emergency Nursing, Placebo, law.invention, Placebos, Randomized controlled trial, law, Internal medicine, Humans, Medicine, Prospective Studies, Treatment Failure, cardiovascular diseases, Intensive care medicine, Prospective cohort study, Antihypertensive Agents, Survival analysis, Aged, Heart Failure, Mechanism (biology), business.industry, Middle Aged, Prognosis, medicine.disease, Survival Analysis, Clinical trial, Treatment Outcome, Valsartan, Heart failure, Emergency Medicine, Val heft, Cardiology, Female, Cardiology and Cardiovascular Medicine, business, medicine.drug
Abstract

The magnitude of benefit on mortality of combined angiotensin-converting enzyme inhibitor (ACEI) and beta-blocker (BB) therapy for heart failure cannot be reliably assessed from prospective randomized trials of individual drugs with intent-to-treat analysis. The placebo arm of the Valsartan Heart Failure Trial (Val-HeFT) included patients who remained on background therapy with ACEIs, BBs, neither, or both. The outcomes in these four subgroups should provide a better guide to mortality benefit. Overall mortality (mean follow-up, 23 months) was 31.6% in those receiving neither neurohormonal blocker, 29% and 39% lower in those on ACEIs or BBs, respectively, and 62% lower (11.9% mortality) in those receiving both drugs. In the neither neurohormonal inhibitor group, 48% of the heart failure-related deaths were adjudicated as sudden, whereas in the group receiving ACEIs and BBs, 79% of the deaths were sudden, and pump failure mortality was only 1% per year. The combination of ACEIs and BBs exerts a greater mortality reduction than suggested from clinical trials and reduces pump failure mortality to 1% per year.

Published
2006

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