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6 results on '"Pollini, S"'

1. Colistin resistance superimposed to endemic carbapenem-resistant Klebsiella pneumoniae: a rapidly evolving problem in Italy, November 2013 to April 2014

Author

Monaco, M, Giani, T, Raffone, M, Arena, F, Garcia Fernandez, A, Pollini, S, Network EuSCAPE Italy, Grundmann, H, Pantosti, A, Rossolini, Gm, Collaborators, Barbaro, A, Campion, L, Catania, M, De Bernochi, A, Di Taranto AM, Dusi, P, Grandesso, S, Luzzaro, F, Manso, E, Meledandri, M, Mencacci, A, Milano, F, Parisi, G, Pecile, P, Restelli, A, Rocchetti, A, Arrigo, C, Rossi, M, Santino, Iolanda, Sarti, M, and Sartor, A.

Subjects
Carbapenem, Endemic Diseases, Epidemiology, Carbapenem resistant Klebsiella pneumoniae, Microbial Sensitivity Tests, Drug resistance, Polymerase Chain Reaction, beta-Lactamases, Microbiology, Colistin resistance, Bacterial Proteins, Drug Resistance, Multiple, Bacterial, Virology, polycyclic compounds, medicine, Humans, biology, Colistin, Public Health, Environmental and Occupational Health, Outbreak, biochemical phenomena, metabolism, and nutrition, Laboratories, Hospital, bacterial infections and mycoses, medicine.disease, biology.organism_classification, Health Surveys, Enterobacteriaceae, Anti-Bacterial Agents, Klebsiella Infections, Klebsiella pneumoniae, Carbapenems, Italy, Klebsiella pneumonia, Sentinel Surveillance, medicine.drug
Abstract

Consecutive non-replicate clinical isolates (n=191) of carbapenem non-susceptible Enterobacteriaceae were collected from 21 hospital laboratories across Italy from November 2013 to April 2014 as part of the European Survey on Carbapenemase-producing Enterobacteriaceae (EuSCAPE) project. Klebsiella pneumoniae carbapenemase-producing K. pneumoniae (KPC-KP) represented 178 (93%) isolates with 76 (43%) respectively resistant to colistin, a key drug for treating carbapenamase-producing Enterobacteriaceae. KPC-KP colistin-resistant isolates were detected in all participating laboratories. This underscores a concerning evolution of colistin resistance in a setting of high KPC-KP endemicity.

Published
2014
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3. Molecular typing of Staphylococcus aureus isolates from an intensive care unit

Author

Giacomo Zanelli, Pollini, S., Sansoni, A., Cresti, S., Pilli, E., Rossolini, Gm, and Cellesi, C.

Subjects
Coagulase, DNA, Bacterial, S.aureus, MRSA, PFGE, Intensive care unit, Inpatients, Staphylococcus aureus, Polymorphism, Genetic, Chromosomes, Bacterial, Staphylococcal Infections, Bacterial Typing Techniques, Electrophoresis, Gel, Pulsed-Field, Hospitals, University, Intensive Care Units, Bacterial Proteins, Italy, Genes, Bacterial, Drug Resistance, Multiple, Bacterial, Methicillin Resistance, Staphylococcal Protein A, Polymorphism, Restriction Fragment Length
Abstract

Seventeen S. aureus clinical isolates, collected from an Intensive Care Unit (ICU) during a seven-month period were analyzed to investigate their antimicrobial susceptibility and clonal diversity. Eleven isolates (65%) were found to be resistant to methicillin (MRSA). Pulsed-field gel electrophoresis (PFGE) profiles of genomic DNAs, and analysis of the polymorphisms of the variable regions of the protein A (spa) and coagulase (coa) genes revealed a lower clonal heterogeneity among MRSA than among methicillin-susceptible isolates (MSSA). Two of the MRSA clones were repeatedly isolated in different patients, within a variable period of time, suggesting the presence in the ward of a resident, endemic and multi-drug resistant MRSA population. Our results also emphasize the lower discriminatory power of spa and coa typing compared with PFGE typing.

Published
2004

6. Colistin resistance superimposed to endemic carbapenem-resistant Klebsiella pneumoniae: a rapidly evolving problem in Italy, November 2013 to April 2014

Author

Monaco, M., Giani, T., Raffone, M., Arena, F., Garcia-Fernandez, A., Pollini, S., Grundmann, H., Pantosti, A., Gian Maria ROSSOLINI, and Microbes in Health and Disease (MHD)

Subjects
ENTEROBACTERIACEAE, HOSPITALS, OUTBREAK, Anti-Bacterial Agents, Bacterial Proteins, Carbapenems, Colistin, Drug Resistance, Multiple, Bacterial, Endemic Diseases, Health Surveys, Humans, Italy, Klebsiella Infections, Klebsiella pneumoniae, Laboratories, Hospital, Microbial Sensitivity Tests, Polymerase Chain Reaction, Sentinel Surveillance, beta-Lactamases, ComputingMethodologies_DOCUMENTANDTEXTPROCESSING, polycyclic compounds, SPREAD, biochemical phenomena, metabolism, and nutrition, bacterial infections and mycoses, GeneralLiterature_REFERENCE(e.g.,dictionaries,encyclopedias,glossaries)

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