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1. Ultraviolet-photon fingerprints on chondritic large organic molecules

Author

Laurette Piani, Shogo Tachibana, Hiroshi Naraoka, Olivier Poch, Cédric Wolters, Iyo Sugawara, Véronique Vuitton, Frédéric Moynier, Laurène Flandinet, R. Thissen, François-Régis Orthous-Daunay, Institut de Planétologie et d'Astrophysique de Grenoble (IPAG), Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Observatoire des Sciences de l'Univers de Grenoble (OSUG ), Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut national des sciences de l'Univers (INSU - CNRS)-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), Centre de Recherches Pétrographiques et Géochimiques (CRPG), Institut national des sciences de l'Univers (INSU - CNRS)-Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS), Institut de Physique du Globe de Paris (IPGP), Institut national des sciences de l'Univers (INSU - CNRS)-IPG PARIS-Université Paris Diderot - Paris 7 (UPD7)-Université de La Réunion (UR)-Centre National de la Recherche Scientifique (CNRS), Hokkaido University [Sapporo, Japan], Kyushu University [Fukuoka], The University of Tokyo (UTokyo), Centre National d'Études Spatiales [Toulouse] (CNES)-Université Grenoble Alpes (UGA)-Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire des Sciences de l'Univers de Grenoble (OSUG), Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP)-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Université Joseph Fourier - Grenoble 1 (UJF)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP)-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Université Joseph Fourier - Grenoble 1 (UJF)-Centre National de la Recherche Scientifique (CNRS), and Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS)

Subjects
chemistry.chemical_classification, Photon, [SDU.ASTR.EP]Sciences of the Universe [physics]/Astrophysics [astro-ph]/Earth and Planetary Astrophysics [astro-ph.EP], 010502 geochemistry & geophysics, medicine.disease_cause, 01 natural sciences, Astrobiology, Organic molecules, Cosmochemistry, Interstellar medium, Geophysics, Meteorite, chemistry, Geochemistry and Petrology, 0103 physical sciences, medicine, Organic matter, 010303 astronomy & astrophysics, ComputingMilieux_MISCELLANEOUS, Ultraviolet, 0105 earth and related environmental sciences
Abstract

International audience

Published
2019
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4. Radical mechanisms of methyl vinyl ketone oligomerization through aqueous phase OH-oxidation: on the paradoxical role of dissolved molecular oxygen

Author

P. Renard, F. Siekmann, A. Gandolfo, J. Socorro, G. Salque, S. Ravier, E. Quivet, J.-L. Clément, M. Traikia, A.-M. Delort, D. Voisin, R. Thissen, and A. Monod

Abstract

It is now accepted that one of the important pathways of Secondary Organic Aerosol (SOA) formation occurs through aqueous phase chemistry in the atmosphere. However, the liquid phase chemical mechanisms leading to macromolecules are still not well understood. For α-dicarbonyl precursors, such as methylglyoxal and glyoxal, radical reactions through OH-oxidation produce oligomers, irreversibly and faster than accretion reactions. Methyl vinyl ketone (MVK) was chosen in the present study as it is an α, β-unsaturated carbonyl that can undergo such reaction pathways in the aqueous phase and forms even high molecular weight oligomers. We present here experiments on the aqueous phase OH-oxidation of MVK, performed under atmospheric relevant conditions. Using NMR and UV absorption spectroscopy, high and ultra-high resolution mass spectrometry, we show that the fast formation of oligomers up to 1800 Da is due to radical oligomerization of MVK, and 13 series of oligomers (out of a total of 26 series) are identified. The influence of atmospherically relevant parameters such as temperature, initial concentrations of MVK and dissolved oxygen are presented and discussed. In agreement with the experimental observations, we propose a chemical mechanism of OH-oxidation of MVK in the aqueous phase that proceeds via radical oligomerization of MVK on the olefin part of the molecule. This mechanism highlights the paradoxical role of dissolved O2: while it inhibits oligomerization reactions, it contributes to produce oligomerization initiator radicals, which rapidly consume O2, thus leading to the supremacy of oligomerization reactions after several minutes of reaction. These processes, together with the large ranges of initial concentrations investigated (60–656 μM of dissolved O2 and 0.2–20 mM of MVK) show the fundamental role that O2 likely plays in atmospheric organic aerosol.

Published
2013
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6. Similar effectiveness of methyl aminolevulinate and 5-aminolevulinate in topical photodynamic therapy for nodular basal cell carcinoma

Author

Daniëlle I, Kuijpers, Monique R, Thissen, Carleine A, Thissen, and Martino H, Neumann

Subjects
Photosensitizing Agents, Skin Neoplasms, Treatment Outcome, Photochemotherapy, Carcinoma, Basal Cell, Administration, Topical, Humans, Pilot Projects, Aminolevulinic Acid, Pain Measurement
Abstract

Photodynamic therapy (PDT) for basal cell carcinoma (BCC) is a treatment modality that is increasingly used in dermato-oncology. Currently, 2 topical photosensitizers, 5-aminolevulinate (ALA) and methyl aminolevulinate (MAL) are widely used, but their efficacy in BCC has not yet been compared in a clinical setting.To evaluate the effect, degree of pain, and costs of ALA-PDT versus MAL-PDT in nodular BCC (nBCC).Patients suffering from BCC were randomly assigned to either ALA-PDT (n=22) or MAL-PDT (n=21) in a pilot study. In each group, half of the tumors were debulked prior to PDT. Eight weeks after treatment, the therapeutic outcome was checked histologically. Pain scores were assessed using a visual analogue scale.Residual tumor tissue was detected in 6 BCCs of each study group. No significant difference between ALA-PDT and MAL-PDT was found with regard to therapeutic efficacy and pain scores. Of note, however, the costs of MAL-PDT were 6-fold higher than those of ALA-PDT.In this study we did not observe any differences in short-term efficacy between ALA-PDT and MAL-PDT. Therefore, both ALA and MAL can be equally recommended as topical photosensitizers in PDT.

Published
2006

7. High resolution spectroscopy at LURE

Author

D. Thomas, M. Coville, R. Thissen, and P. Morin

Subjects
Nuclear and High Energy Physics, Materials science, Optics, business.industry, High resolution, Spectroscopy, business, Atomic and Molecular Physics, and Optics
Published
1992
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8. List of participants

Author

M. Abe, M. Abo, T. Abukawa, J. Adachi, A. Agui, O. Aita, Y. Aiura, J. Ajello, O. Akaki, H. Akazawa, H. Aksela, S. Aksela, J. Allen, Z. Altun, K. Amemiya, M. Amusia, K. An, J. Andersen, S. Aoki, I. Arakawa, T. Araki, U. Arp, M. Asensio, Y. Awaya, K. Awazu, H. Azuma, Y. Azuma, Y. Baba, H. Bando, Z. Bao, U. Becker, P. Bengtsson, S. Bobashev, A. Bocquet, J. Breton, Y. Cai, C. Caldwell, C. Cauletti, A. Chainani, J. Che, C. Chen, L. Chen, X. Chen, N. Cherepkov, T. Cho, C. Christou, J. Chung, M. Couprie, S. Cramer, L. Da Silva, H. Daimon, K. Deguchi, D. Dessau, V. Dhanak, V. Dolmatov, W. Drube, S. Echigo, A. Ehresmann, S. Eisebitt, T. Ejima, A. Ejiri, O. Endo, J. England, Y. Enta, C. Fadley, J. Feldhaus, E. Filatova, M. Finazzi, M. Finkenthal, D. Fischer, U. Flechsig, K. Franzén, L. Frasinski, T. Fujikawa, A. Fujimori, S. Fujimori, M. Fujisawa, K. Fujita, M. Fujita, K. Fukui, H. Fukutani, J. Ghijsen, E. Gluskin, Q. Guo, P. Guyon, C. Hague, R. Hall, H. Hamamatsu, Z. Han, J. Hansen, T. Hanyu, N. Happo, T. Hara, I. Harada, Y. Harada, M. Hasegawa, S. Hasegawa, T. Hatano, P. Hatherly, T. Hattori, T. Hayaishi, T. Hayasi, C. Heck, U. Heinzmann, K. Hieda, K. Higashiyama, Y. Hirai, A. Hiraya, T. Hirayama, S. Hirose, A. Hishikawa, A. Hopkirk, Y. Horikawa, N. Hosaka, K. Huber, W. Huff, Z. Hussain, C. Hwang, K. Ibrahim, T. Ibuki, K. Ichikawa, M. Ichikawa, J. Igarashi, Y. Iguchi, K. Iimura, D. Iinuma, Y. Iketaki, H. Ikeura, S. Imada, Y. Imaizumi, A. Imanishi, H. Inokuchi, I. Inoue, M. Ishigame, E. Ishiguro, H. Ishii, T. Ishii, H. Ishijima, I. Ishizue, G. Isoyama, K. Ito, M. Itoh, Y. Itoh, M. Iwami, K. Iwano, K. Iwasaki, S. Iwata, C. Jacobsen, T. Jikimoto, T. Jo, L. Johansson, U. Johansson, K. Jouda, C. Jung, N. Kabachnik, G. Kaindl, A. Kakizaki, M. Kamada, A. Kamata, I. Kamenskikh, K. Kameta, K. Kamiya, Y. Kamiya, K. Kan'no, T. Kanomata, M. Kasaya, T. Kashiwakura, R. Kato, Y. Kato, R. Katoh, T. Kaurila, J. Kawai, T. Kawamura, Y. Kayanuma, K. Kaznacheyev, E. Kennedy, M. Kiguchi, H. Kihara, Y. Kimpara, A. Kimura, H. Kimura, K. Kimura, S. Kimura, T. Kinoshita, M. Kirm, E. Kisker, T. Kitade, M. Kitajima, Y. Kitajima, H. Kitamura, M. Kitaura, K. Kobayashi, M. Kobayashi, T. Koda, J. Kohagura, T. Koide, F. Koike, M. Koike, T. Koike, T. Koizumi, T. Kojima, K. Kondo, Y. Kondo, M. Kono, S. Kono, R. Korde, T. Koseki, N. Kosugi, A. Kotani, M. Kotani, N. Kouchi, M. Kowalski, M. Koyama, I. Koyano, M. Krause, J. Krupa, H. Kumigashira, T. Kuninobu, S. Kurita, M. Kusaka, G. Kutluk, P. Lablanquie, F. Lama, F. Larkins, C. Latimer, T. Lebrun, D. Lee, K. Lee, T. Lee, F. Legrand, B. Lewis, D. Li, I. Lindau, F. Liu, G. Lodha, E. Lu, A. Lushchik, I. Lyakhovskaya, N. Mårtensson, Y. Ma, S. Machida, F. Maeda, S. Maeyama, H. Maezawa, N. Manakov, G. Margaritondo, S. Masui, T. Masuoka, F. Matsui, T. Matsukawa, M. Matsumoto, S. Matsumoto, T. Matsushita, M. Matsuzawa, G. Mattogno, A. Messina, V. Mikhailin, K. Mimura, T. Minami, A. Misu, T. Mitsuishi, K. Mitsuke, R. Mitsumoto, T. Miyahara, T. Miyamae, N. Miyamoto, H. Miyauchi, T. Mizokawa, H. Morgan, I. Mori, T. Mori, P. Morin, Y. Morioka, J. Mosnier, I. Munro, E. Murakami, T. Murata, Y. Murata, T. Muro, I. Nagakura, S. Nagaoka, T. Nagata, L. Nahon, K. Nakagawa, I. Nakai, S. Nakai, Y. Nakai, H. Nakaishi, N. Nakajima, H. Nakamura, M. Nakamura, M. Nakatake, M. Nakazawa, H. Namatame, T. Namioka, T. Nanba, S. Naoe, K. Nasu, M. Neeb, I. Nenner, Y. Nishihara, H. Nishioka, M. Niwano, J. Nordgren, D. Norman, C. Nowak, R. Nyholm, H. Nylén, H. Ogasawara, T. Ogata, S. Oh, J. Ohara, H. Ohashi, T. Ohchi, K. Ohmori, A. Ohnishi, N. Ohno, T. Ohta, H. Oji, K. Okada, T. Okajima, T. Okane, T. Okuda, M. Okunishi, M. Okusawa, C. Olson, M. Onellion, I. Ono, K. Ono, J. Onsgaard, H. Onuki, M. Oshima, I. Ouchi, Y. Ouchi, M. Oura, C. Park, S. Park, R. Perera, Y. Petroff, E. Poliakoff, W. Pong, K. Prabhakaran, R. Pratt, M. Qvarford, O. Rader, S. Rahn, K. Randall, R. Reininger, R. Rosenberg, J. Rubensson, P. Sainctavit, N. Saito, T. Saito, T. Saitoh, Y. Saitoh, K. Sakamoto, M. Sakano, Y. Sakisaka, J. Samson, D. Sarma, T. Sasaki, T. Sasano, H. Sato, N. Sato, S. Sato, Y. Sato, E. Savchenko, W. Schattke, F. Schlachter, V. Schmidt, N. Schwentner, K. Seki, T. Sekiguchi, T. Sekitani, A. Sekiyama, H. Seno, M. Shafi, T. Sham, L. Sheng, C. Shi, T. Shidara, E. Shigemasa, H. Shimada, K. Shimada, I. Shimamura, Y. Shimizu, I. Shimoyama, S. Shin, H. Shiraga, M. Shirai, T. Shishidou, L. Shmaenok, K. Shobatake, M. Simon, N. Smith, K. Soda, A. Solov'yov, B. Sonntag, D. Spanke, V. Stankevitch, I. Steinberger, P. Steiner, S. Suga, H. Sugawara, D. Sutherland, I. Suzuki, M. Suzuki, N. Suzuki, S. Suzuki, T. Suzuki, Y. Taguchi, N. Takahashi, T. Takahashi, Y. Takakuwa, Y. Takata, K. Takatsuchi, A. Takeichi, H. Takenaka, Y. Takizawa, A. Tanaka, K. Tanaka, M. Tanaka, S. Tanaka, T. Tanaka, J. Tang, K. Tani, M. Taniguchi, T. Tayu, S. Terada, L. Terminello, H. Tezuka, Y. Tezuka, R. Thissen, M. Tinone, I. Tokue, B. Tonner, E. Toyota, P. Troussel, K. Ueda, Y. Ueda, N. Ueno, R. Uhrberg, M. Ukai, T. Umehara, T. Uozumi, T. Urisu, P. Vaeterlein, G. Van der Laan, M. Van Hove, P. Viane, J. Voss, X. Wang, M. Watanabe, N. Watanabe, Y. Watanabe, J. Weaver, J. West, E. van Wezenbeek, S. Whitfield, D. Woodruff, L. Wu, R. Wu, P. Xu, W. Xu, K. Yagi, S. Yagi, A. Yagishita, T. Yamada, T. Yamakawa, H. Yamamoto, M. Yamamoto, Y. Yamamoto, T. Yamanaka, K. Yamanouchi, K. Yamashita, M. Yanagihara, S. Yang, Y. Yang, H. Yeom, M. Yimagawa, R. Ynzunza, T. Yokoya, T. Yokoyama, A. Yoshida, H. Yoshida, K. Yoshi, D. Yoshimura, M. Yuri, T. Zama, P. Zeitoun, X. Zhang, Y. Zhang, G. Zimmerer, and R. Zimmermann

Published
1996
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9. Fragmentation of core excited methylamine

Author

R. Thissen, P. Morin, J. Delwiche, M.-J. Hubin-Franskin, M. Furlan, I. Nenner, and Michel Lavollée

Subjects
Fragmentation (mass spectrometry), Chemistry, Electron excitation, Excited state, Ionization, Photoionization, Rydberg state, Atomic physics, Ion, Dication
Abstract

The dynamics of CH3NH2 after Nitrogen 1s electron excitation has been studied using the synchrotron radiation from SuperACO, L.U.R.E. storage ring, and by the photoionization method coupled to time‐of‐flight mass spectrometry and coincidence spectroscopy. The dissociation patterns of the singly and doubly charged molecular ions formed after relaxation of the Nitrogen 1s core hole have been shown to be dependent of the initial electronic transition (Rydberg state or ionization continuum) and of the one or two hole(s) final configuration. We have also shown the existence of stable states of the dication and important rearrangement processes inside of the singly or doubly charged ions.

Published
1992
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10. Mykotoxine von luftgetragenen Fadenpilzen und ihre Relevanz für die Arbeitsplatz- und Umwelthygiene

Author

Dohms E, Müller T, R Schwalbe, Fischer G, R Thißen, Silvia Braun, and Wolfgang Dott

Subjects
Chemistry, Toxicology, Microbiology, Molecular biology, Biotechnology
Abstract

Die Wiederverwertung von organischem Abfall (Kompostierung) und Kunststoff-verpackungen (DSD-Sammlung) bildet einen wichtigen Teil der kommunalen Abfallentsorgung. Der Prozess der Kompostierung ist vor allem auf die Aktivitat von Fadenpilzen zuruckzufuhren, deren Sporen durch die Handhabung des Abfalls/Kompostes in die Luft gelangen. Die toxikologische Relevanz von Sekundarmetaboliten luftgetragener Fadenpilze in Abfallbehandlungsanlagen wird zur Zeit kontrovers diskutiert. Durch Anhaften von Lebensmittelresten kann es zur Vermehrung von Fadenpilzen auf dem DSD-Abfall kommen, so das wahrend der Sortierung und Weiterverarbeitung der Kunststoffe Sporen freigesetzt werden. Vorherrschend sind bei beiden Verfahrenstechniken toxinbildende Arten, wieAspergillus fumigatus (Verruculogen, Gliotoxin, Fumitremorgin),Emericella nidulans (Sterigmatocystin),Paecilomyces variotii (Viriditoxin),Aspergillus flavus (Aflatoxin) undPenicillium crustosum (Penitrem A). In der vorliegenden Untersuchung soll gepruft werden, ob die Mykotoxine in den Sporen der Fadenpilze vorkommen und ob sie auf naturlichen Substraten gebildet werden.

Published
2000
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12. An improved synthesis of N-acetoxy-N-acetyl-2-aminofluorene-9-14C using an extractive acylation technique

Author

W. P. Duncan and M. R. Thissen

Subjects
chemistry.chemical_classification, Hydroxamic acid, Organic Chemistry, Salt (chemistry), Biochemistry, Analytical Chemistry, Acylation, chemistry.chemical_compound, Acetic anhydride, chemistry, Acetylation, Yield (chemistry), Drug Discovery, Organic chemistry, Radiology, Nuclear Medicine and imaging, Ammonium, Specific activity, Spectroscopy
Abstract

A rapid, high yield (90–100%) method for the preparation of N-acetoxy-N-acetyl-2-aminofluorene-9-14C (N-AcO-AAF-9-14C) from N-hydroxy-N-acetyl-2-aminofluorene-9-14C (N-OH-AAF-9-14C) is described. The procedure consists of the in situ formation of a quaternary ammonium salt of N-OH-AAF-9-14C in a two-phase system and subsequent acetylation of this salt with acetic anhydride. The specific activity of the product was 40.6 mCi/mmole.

Published
1978
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13. Metabolic activation of arylhydroxamic acids by N-O-acyltransferase of rat mammary gland

Author

C M, King, N R, Traub, Z M, Lortz, and M R, Thissen

Subjects
Hydroxyacetylaminofluorene, Hydroxamic Acids, Rats, Inbred F344, Rats, Substrate Specificity, Enzyme Activation, Mammary Glands, Animal, Species Specificity, RNA, Ribosomal, Neoplasms, Chromatography, Gel, Aminobiphenyl Compounds, Animals, Female, Acyltransferases, Biotransformation
Abstract

The lactating mammary glands of rats contain an arylhydroxamic acid N,O-acyltransferase that catalyzes the formation of arylamine-substituted nucleic acid on incubation with N-hydroxy-N-2-acetylaminofluorene or N-hydroxy-N-4-acetylaminobiphenyl and transfer RNA. The acyltransferase activity migrates as a single component with a molecular weight of 28,000 on gel filtration on Sephadex G-100. Acyltransferase activities of the lactating mammary glands of Sprague-Dawley animals are approximately twice those of the less susceptible Fischer strain as determined by assay with either hydroxamic acid. The fluorene substrate was 15 times as efficient as the biphenyl compound in promoting adduct formation. Ribosomal RNA adducts formed in vivo after administration of N-hydroxy-N-2-acetylaminofluorene were consistent with an acyltransferase mechanism of activation in that the adducts did not retain the acetyl group.

Published
1979

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