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Phosphorus (P) is a major element required for plant growth and development. To cope with P shortage, plants activate local and long-distance signaling pathways, such as an increase in the production and exudation of strigolactones (SLs). The role of the latter in mitigating P deficiency is, however, still largely unknown. To shed light on this, we studied the transcriptional response to P starvation and replenishment in wild-type rice and a SL mutant, dwarf10 (d10), and upon exogenous application of the synthetic SL GR24. P starvation resulted in major transcriptional alterations, such as the upregulation of P TRANSPORTER, SYG1/PHO81/XPR1 (SPX) and VACUOLAR PHOSPHATE EFFLUX TRANSPORTER. Gene Ontology (GO) analysis of the genes induced by P starvation showed enrichment in phospholipid catabolic process and phosphatase activity. In d10, P deficiency induced upregulation of genes enriched for sesquiterpenoid production, secondary shoot formation and metabolic processes, including lactone biosynthesis. Furthermore, several genes induced by GR24 treatment shared the same GO terms with P starvation-induced genes, such as oxidation reduction, heme binding and oxidoreductase activity, hinting at the role that SLs play in the transcriptional reprogramming upon P starvation. Gene co-expression network analysis uncovered a METHYL TRANSFERASE that displayed co-regulation with known rice SL biosynthetic genes. Functional characterization showed that this gene encodes an enzyme catalyzing the conversion of carlactonoic acid to methyl carlactonoate. Our work provides a valuable resource to further studies on the response of crops to P deficiency and reveals a tool for the discovery of SL biosynthetic genes.

Various authors see human flourishing as the overarching aim to which education should contribute. We ask whether fostering wonder can help education attain this aim. We discuss two possibilities: firstly, it may be that having a sense of wonder as adults (possibly fostered by and/or refined due to education) contributes to flourishing itself. Secondly, it may be that fostering wonder in education increases the likelihood that education promotes flourishing, which it might do simply by increasing children’s intrinsic interest in what they learn. We argue that there are many plausible connections between wonder and human flourishing (relating to its epistemic and aesthetic dimensions, among others), and that we have reason to believe that early experiences can influence adults’ capacity for wonder. Furthermore, wonder increases the likelihood that education ‘succeeds’; and it supports people’s ability to live well by heightening their appreciation for the world, helping to uncover baseless beliefs, and increasing their awareness of possible goods. In sum, while having a sense of wonder may not be a constitutive element of human flourishing, it is hard to imagine education for human flourishing that is not also wonder-full education.

While the design of goods and services is undeniably important in cultivating customer engagement (CE) with industrial innovations, the theoretical interface of industrial design, innovation, and CE remains nebulous, exposing an important literature-based gap. Relatedly, while the literature has focused on the firm as the focal designing stakeholder, further knowledge building is needed regarding the engagement of other stakeholders (e.g., employees or fellow customers), who may co-design an industrial firm’s offering (e.g., by contributing to its product development activity), and its effect on CE. That is, as co-designing stakeholders can help design industrial offerings through their respective engagement, we advance an omni-stakeholder perspective of industrial design in this paper. We address these issues by composing a conceptual model and an associated set of propositions that explore the effect of different stakeholders’ engagement in co-designing industrial innovations, and their respective effect on CE with the innovation. Next, we introduce the papers contained in this Issue and their links to the framework. We conclude by outlining further research avenues that arise from our analyses.

Social work professionals in urban contexts struggle to serve different groups equally. Critical social work literature advocates critical reflexivity in social work practices. Focusing on existing support practices, it encourages scrutinising the implicit ways social work practices can maintain and reproduce power imbalances and othering structures. However, it has not examined the tensions connected with phases in which the first contact between clients and professionals occurs and clients’ engagement in social work programmes begins. Stimulated by an empirical research into parenting-support in a city in the Netherlands, this article examines theoretically the notion of ‘encounter practices’ through which professionals reach out to people considered in need of support but not asking for help. We disentangle how encounter practices can be interpreted through different understandings of professional engagement, emerging from either critical or affirmative traditions of social work. The encounter context poses specific challenges for critical reflexivity, but it also offers the possibility of exploring one’s social positioning in relation to others through informal micro-interactions preceding the instalment of professional relations between professionals and parents. Drawing on insights from urban studies, we distinguish ‘fleeting’, ‘convivial’ and ‘engaged encounters’ as different levels of encounter that allow unsettling othering structures in outreach practices.

Many firms use augmented reality (AR) that projects lifelike product holograms into the physical environment to assist customers in bridging so-called “imagination gaps,” which can arise on their path to purchase. However, research has not yet studied whether and how AR might help customers address two pertinent sources of such imagination gaps: (1) increased cognitive load when evaluating multiple products together (e.g., in a bundle) and (2) extended physical distance to the point-of-sale (e.g., out-of-store, at home). Building on mental imagery theorizing, we explain how AR supports customers in bridging these gaps, and, through a series of field and experimental studies, we evidence effects on customer purchase intentions and behavior. Specifically, we show that AR-generated imagery of bundled (versus individual) products enhances intended and actual purchases at the point-of-sale. Furthermore, when deployed at distant points in the purchase funnel (out-of-store, at-home), AR increases purchases through improved self-projection, which we describe as the psychological mechanism customers use to mentally bridge distance to the point-of-sale. We qualify this mediating mechanism through an important moderating process, where the effect of AR-generated imagery on self-projection is suppressed for customers with a holistic (versus analytic) thinking style.

Two similar watercraft depicted in rock art at Awunbarna, Arnhem Land, Australia, are unlike the Macassan prahus and Western craft shown at other contact sites in northern Australia, but are sufficiently detailed to offer evidence for identification. Both craft appear to display triangular flags, pennants, and prow adornments indicating martial status. By comparing these two depictions with historically recorded watercraft from Island Southeast Asia, their probable origin is shown to have been eastern Maluku Tenggara in Indonesia. These motifs provide the first known direct archaeological evidence for ethnic diversity for the origins of mariners from Island Southeast Asia other than Makassar, Sulawesi. The rock-art depictions are representative of ceremonially decorated fighting craft used to lead trading voyages and raids, and may be linked to trade, fishing, resource exploitation, or slavery. This potentially unique identification of Moluccan watercraft in Arnhem Land rock art offers evidence of the elusive encounters between the Indigenous people of northern Australia and people from the archipelagos to the north, evidence with which to expand both the nature and context of Australia’s contact narrative.

International audience; Physical activity (PA) is recognized as a marker of health. The aim was to investigate PA differences from adolescence to young adulthood. European adolescents included in the HELENA study were invited to participate in a follow-up study, 10 years later. The present study included 141 adults (25.0 ± 1.4 years) for whom valid accelerometer data were available in adolescence and adulthood. Changes in PA by sex, weight and maternal education level were explored with interactions. Time spent in sedentary activity, light PA (LPA) and moderate PA (MPA) increased by 39.1, 59.6 and 6.6 min/day, respectively, whereas the time spent in vigorous PA (VPA) decreased by 11.3 min/day compared with adolescent VPA (p

The present study evaluated the effects of increasing the dietary levels of EPA and DHA in Atlantic salmon (Salmo salar) reared in sea cages, in terms of growth performance, welfare, robustness and overall quality. Fish with an average starting weight of 275 g were fed one of four different diets containing 10, 13, 16 and 35 g/kg of EPA and DHA (designated as 1·0, 1·3, 1·6 and 3·5 % EPA and DHA) until they reached approximately 5 kg. The 3·5 % EPA and DHA diet showed a significantly beneficial effect on growth performance and fillet quality compared with all other diets, particularly the 1 % EPA and DHA diet. Fish fed the diet containing 3·5 % EPA and DHA showed 400–600 g higher final weights, improved internal organ health scores and external welfare indicators, better fillet quality in terms of higher visual colour score and lower occurrence of dark spots and higher EPA and DHA content in tissues at the end of the feeding trial. Moreover, fish fed the 3·5 % EPA and DHA diet showed lower mortality during a naturally occurring cardiomyopathy syndrome outbreak, although this did not reach statistical significance. Altogether, our findings emphasise the importance of dietary EPA and DHA to maintain good growth, robustness, welfare and fillet quality of Atlantic salmon reared in sea cages.

Psychological theories of habit posit that when a strong habit is formed through behavioral repetition, it can trigger behavior automatically in the same environment. Given the reciprocal relationship between habit and behavior, changing lifestyle behaviors is largely a task of breaking old habits and creating new and healthy ones. Thus, representing users’ habit strengths can be very useful for behavior change support systems, for example, to predict behavior or to decide when an intervention reaches its intended effect. However, habit strength is not directly observable and existing self-report measures are taxing for users. In this paper, building on recent computational models of habit formation, we propose a method to enable intelligent systems to compute habit strength based on observable behavior. The hypothesized advantage of using computed habit strength for behavior prediction was tested using data from two intervention studies on dental behavior change ($$N = 36$$N=36and$$N = 75$$N=75), where we instructed participants to brush their teeth twice a day for three weeks and monitored their behaviors using accelerometers. The results showed that for the task of predicting future brushing behavior, the theory-based model that computed habit strength achieved an accuracy of 68.6% (Study 1) and 76.1% (Study 2), which outperformed the model that relied on self-reported behavioral determinants but showed no advantage over models that relied on past behavior. We discuss the implications of our results for research on behavior change support systems and habit formation.

Background Rice is the second most produced crop worldwide, but it is highly susceptible to drought-induced yield loss. Micro-organisms can potentially alleviate the negative effects of drought but how they are associated with their host is unclear. The aim of the present study was to unravel the genetic factors involved in this process, and whether it plays a role in rice drought tolerance. Results To achieve this, we characterized the composition of the root-mycobiota in 296 rice accessions (Oryza sativaL. subsp. indica), grown in the field under control and drought conditions. A Genome Wide Association Study (GWAS) was used to identify marker-trait associations between rice Single Nucleotide Polymorphism (SNP) markers and root mycobiota. This resulted in the identification of ten significant (LOD > 4) SNPs associated with six root associated fungi and four significant SNPs associated with fungi-mediated drought tolerance. The analysis of the genes underlying the loci of the significant marker-trait associations identified a priori candidates including genes known to be involved in pathogen defense, abiotic stress responses and cell-wall remodeling processes. Conclusion Our study shows that the rice genetics affects the recruitment of fungi, some of which affect yield under drought, and provides candidate gene targets for breeding to improve rice-fungal interactions and drought tolerance.

Submission note: A thesis submitted in total fulfilment of the requirements for the degree of Doctor of Philosophy to the School of Molecular Sciences, La Trobe University, Bendigo.Organic phosphorus compounds account for up to 80 % of total phosphorus in soils, with myo-inositol hexaphosphate (IP6) an important source. Cycling of inositol phosphates represents a substantial gap in our understanding of the global phosphorus cycle. This thesis describes binary and ternary sorption systems involving IP6, cadmium (Cd(II)), humic acid (HA) and the soil minerals gibbsite and kaolinite. These systems were investigated using sorption experiments, solid-state 31P NMR measurements and surface complexation modelling. IP6 sorption to gibbsite decreased with increasing pH while with increasing temperature sorption increased at pH 6 and decreased at pH 10. 31P NMR information indicated sorption involved a combination of outer and inner-sphere complexation and surface precipitation. IP6 sorption to kaolinite generally decreased with increasing pH and the effect of temperature was relatively small. Using an Extended Constant Capacitance Model IP6 sorption was modelled on both minerals using a similar set of surface reactions. IP6 influenced Cd(II) sorption to both gibbsite and kaolinite. On gibbsite, Cd(II) sorption increased in the presence of IP6 with the increase more pronounced at higher concentrations. Only small differences were observed in 31P NMR spectra of binary and ternary systems. On kaolinite, IP6 increased Cd(II) sorption between pH 4-8 but supressed it at higher pH. Surface complexation modelling of both mineral systems suggested the formation of ternary surface complexes. For IP6 and HA systems, the presence of IP6 decreased HA sorption to both minerals. The influence of HA on IP6 sorption was more complex, with both the addition sequence and pH altering the changes found. Where HA was bound to the surface at lower pH before the addition of IP6, less IP6 was sorbed. At pH 6 and 10 there was relatively little desorption of IP6 from gibbsite. HA increased desorption somewhat at pH 6, but not at pH 10.

Blindness affects millions of people around the world, and is expected to become increasingly prevalent in the years to come. For some blind individuals, a promising solution to restore a form of vision are cortical visual prostheses, which convert camera input to electrical stimulation of the cortex to bypass part of the impaired visual system. Due to the constrained number of electrodes that can be implanted, the artificially induced visual percept (a pattern of localized light flashes, or ‘phosphenes’) is of limited resolution, and a great portion of the field’s research attention is devoted to optimizing the efficacy, efficiency, and practical usefulness of the encoding of visual information. A commonly exploited method is the non-invasive functional evaluation in sighted subjects or with computational models by making use of simulated prosthetic vision (SPV) pipelines. Although the SPV literature has provided us with some fundamental insights, an important drawback that researchers and clinicians may encounter is the lack of realism in the simulation of cortical prosthetic vision, which limits the validity for real-life applications. Moreover, none of the existing simulators address the specific practical requirements for the electrical stimulation parameters. In this study, we developed a PyTorch-based, fast and fully differentiable phosphene simulator. Our simulator transforms specific electrode stimulation patterns into biologically plausible representations of the artificial visual percepts that the prosthesis wearer is expected to see. The simulator integrates a wide range of both classical and recent clinical results with neurophysiological evidence in humans and non-human primates. The implemented pipeline includes a model of the retinotopic organisation and cortical magnification of the visual cortex. Moreover, the quantitative effect of stimulation strength, duration, and frequency on phosphene size and brightness as well as the temporal characteristics of phosphenes are incorporated in the simulator. Our results demonstrate the suitability of the simulator for both computational applications such as end-to-end deep learning-based prosthetic vision optimization as well as behavioural experiments. The modular approach of our work makes it ideal for further integrating new insights in artificial vision as well as for hypothesis testing. In summary, we present an open-source, fully differentiable, biologically plausible phosphene simulator as a tool for computational, clinical and behavioural neuroscientists working on visual neuroprosthetics.

Introduction: great disruptions: the new normal? Recent history has not been kind to Fukuyama’s ‘end of history’ thesis, expounded thirty years ago (Fukuyama, 1989, 1992). Writing back then, with the fall of the Berlin Wall, and the break-up of the Soviet Union, Fukuyama’s contention concerned what he saw as the triumph of Western-style liberal-democratic free-market capitalism. Subsequent events have thrown such celebratory claims of the success of global political and economic liberalism into question. The resurgence of Russia, the ascendancy of China’s state authoritarianism, and the rise of Islamic fundamentalism are all proof that major ideological contests have far from disappeared. Yet further, over the past two decades or so, disruptions and upheavals within and among the capitalist West itself have revealed the fragility of market-based democracies.

Split-thickness skin grafts (STSG) are commonly required in reconstructive surgery but may cause significant pain. The goal of this investigator-initiated trial is to evaluate the effect of liposomal bupivacaine on donor site pain and opioid consumption. A parallel, randomized, controlled trial of adult acute burn patients with

For service researchers, contributing to academic advancement through academic publications is a raison d’être. Moreover, demand is increasing for service researchers to make a difference beyond academia. Thus, service researchers face the formidable challenge of writing in a manner that resonates with not just service academics but also practitioners, policy makers, and other stakeholders. In this article, the authors examine how service research articles’ lexical variations might influence their academic citations and public media coverage. Drawing on the complete corpus of Journal of Service Research ( JSR) articles published between 1998 and 2020, they use text analytics and thereby determine that variations in language intensity, immediacy, and diversity relate to article impact. The appropriate use of these lexical variants and other stylistic conventions depends on the audience (academic or the public), the subsection of this article in which they appear (e.g., introduction, implications), and article innovativeness. This article concludes with an actionable “how-to” guide for ways to increase article impacts in relation to different JSR audiences.

A document produced by the Shaikh of Bahrain to claim restitution for items plundered from one of his vessels in 1818 gives a macro view of seafaring in the Persian Gulf from the perspective of a l...

The marketing of B2B services has become an important field of academic enquiry. Industrial Marketing Management scholars have contributed to building a robust body of scholarship on the role of services as an indispensable aspect of company’s strategic performance process. However, with digitization, there is a clear need for theoretical concepts and frameworks that can guide companies in the development of contemporary and strategic roadmaps for their B2B service marketing strategies and performance practice. This position paper outlines an agenda and delineates issues in B2B service delivery that need to be addressed to close the gap between service marketing theory and practice and collaborate on the development of strategic service capabilities for the industrial marketing space. More specifically, we identify and discuss the impact of 5 important trends shaping B2B services: 1) gamification, 2) personalization, 3) Mixed Reality (MR), 4) data visualization, and 5) privacy. On the basis of these, we will offer a number of specific directions for future research by industrial marketing researchers.

The role of the source of discrimination in relation to minority Muslim youths’ psychosocial well-being has received remarkably little attention in the post-9/11 climate. We have examined one of the aspects of psychosocial well-being that is given prominent attention in the media and public discourse, namely externalising behaviour. The article reports whether perceived discrimination by four sources (school peers and teachers, peers, and adults outside the school) is related to externalising behaviour. Links between perceived discrimination sources and externalising behaviour among Dutch Muslim youths (n = 308, ages 14–18) were examined through surveys. The quantitative findings guided our qualitative analyses of interviews with 10 Muslim Dutch youths on their accounts of discrimination in the school context. When comparing different discrimination sources, only teacher discrimination was found to predict externalising behaviour significantly (explaining 15% of the variance). The qualitative follow-up illustrated the significance of teacher discrimination: Some Muslim youths felt that their teachers held back their school progress, while others reported receiving insults from teachers about their parents’ native country and their religion. We argue that students’ perceived powerlessness within the teacher-student relationship deserves further attention, as some Dutch Muslim youths reported painful experiences, with perceived teacher discrimination linked to higher levels of externalising behaviour.

The expression that professionals should be led by their moral or ethical compass is increasingly used by academics, policy makers, professionals, and educational institutes. Dutch universities of applied sciences (UAS), for example, explicitly aim to educate their students to become professionals equipped with a moral compass. This moral or ethical compass is a metaphor of which people intuitively grasp its meaning, but our literature review also shows that various interpretations are possible. We found three clusters of proposed ethical compasses expressing its a) content, b) form, or c) use, which we present in this article. Thereafter, we evaluate which compass can meaningfully assist (young) professionals and, therefore, should be part of the aims and content of education provided by UAS. Based on this evaluation, we describe the possibilities and boundaries of UAS’ contribution to the development of their students’ ethical compass.

Self-Portrait

Contains fulltext : 225305.pdf (Publisher’s version ) (Open Access) 10 p.

As suppliers increasingly depend on their indirect sales channel, enablement of channel partners has become a strategic asset. We focus on the central role of deliberate learning within strategic enablement strategy. Specifically, we conceptualize deliberate sales learning as a three-dimensional construct (knowledge articulation, knowledge codification, knowledge certification) and identify the mechanisms through which it impacts on channel partner sales performance. Based on a survey of channel partners (N = 383) of an FT100 company, we establish exploitative and explorative learning orientations as antecedents of deliberate sales learning, where this relationship is moderated by channel partners' preference for online learning formats. The relatively weaker relationship between explorative learning orientation and deliberate sales learning is positively enhanced for those channel partners with a preference for interactive online modules. Further, we demonstrate that deliberate sales learning and deliberate sales practice act in serial mediation to positively impact sales performance. In addition to future research opportunities, we identify three core implications for the practice of strategic sales enablement; enhancing return on investment, managing learner motivation and activating learning engagement of channel partners.

Rationale This article explores the awarding of the 2022 Commonwealth Games to Birmingham in the context of Brexit and Regional Devolution and Development. Approach A mixed methods approach of qualitative data collection supplemented by desktop research was undertaken. The underpinning research philosophy was that of Pragmatism (Morgan, 2014) – triangulating differing ontological & epistemological perspectives. Ten semi-structured interviews were conducted between July 2018 and December 2018 Findings The article critically assesses the potential of the 2022 Games to support regeneration, finding that various factors will continue to impinge on the ability of the 2022 Games to fulfil their promise of a shared vision post-Brexit. Practical implications/Research contribution Much has been made of the potential for major international sporting events to provide a stimulus to areas in need of regeneration, for which Glasgow is often cited as a classic example in the UK, having hosted the Games in 2014 (Scottish Government, 2015). However, Brexit adds a new piquancy to this debate given the desire by senior UK Government figures to rejuvenate ties with the Commonwealth. ? Is there anything distinctive about Birmingham (e.g., the presence of significant "Commonwealth Diaspora" communities) that could assist in this regard?

Across various customer experiences, Augmented Reality (AR) is emerging as a strategic experience design tool. This study contributes to an emerging body of research on the use of AR in the early stages of customers’ purchase journeys. Extending previous research, we propose that AR enables a unique form of customer creativity that is distinct from prior conceptualizations of creativity through its association with customer engagement. Specifically, we propose a sequential process of creative customer engagement, in which AR-enabled customer creativity stems from heightened customer engagement and, in turn, offers a source of intrinsic satisfaction for customers. In an experiment with a customer-facing AR application, we empirically demonstrate this sequential mediation process connecting the use of AR with customer engagement, customer creativity, and anticipated satisfaction. We also identify an important boundary condition based on a customer’s assessment orientation, suggesting a novel behavioral effect in the context of regulatory mode theory.

Résumé Avec Fin de partie : scènes et monologues, opéra en un acte, Győrgy Kurtág rend hommage à Beckett : non pas en accompagnant mais en réponse au texte, dont il n’ a été retenu qu’ une partie, la musique et le chant soulignant la recherche profondément beckettienne du silence et de l’ ailleurs. Pour cela Kurtág s’ appuie également sur les résonances créées par le poème “Roundelay,” autre œuvre beckettienne placée en prologue de l’ opéra.

Complex services, such as healthcare, struggle to realize the benefits of value co-creation due to the substantial challenges of managing such services over the long-term. Key to overcoming these challenges to value co-creation is a profound understanding of dialogue (i.e., ‘quality of discourse’ facilitating shared meaning) during service interactions. Contributing to an emerging literature, we undertake a longitudinal, ethnographic study to assess dialogue between professionals and patients through the lens of dialogic engagement (i.e., iterative mutual learning processes that bring about action through dialogue). We develop and empirically support six dialogic co-creation and co-destruction mechanisms that impact on the resolution of tensions and integration of knowledge resources between service providers and consumers. We reveal the multidimensional and dynamic nature of value created or destroyed through these mechanisms in dialogue over time. Taking healthcare as an exemplar, we offer a research agenda for developing our understanding of DE in complex services.

There is an urgent need to find alternative feed resources that can further substitute fishmeal in Atlantic salmon diets without compromising health and food quality, in particular during the finishing feeding period when the feed demand is highest and flesh quality effects are most significant. This study investigates efficacy of substituting a isoprotein (35 %) and isolipid (35 %) low fishmeal diet (FM, 15 %) with Antarctic krill meal (KM, 12 %) during 3 months with growing finishing 2·3 kg salmon (quadruplicate sea cages/diet). Final body weight (3·9 (se 0·04) kg) was similar in the dietary groups, but the KM group had more voluminous body shape, leaner hearts and improved fillet integrity, firmness and colour. Ectopic epithelial cells and focal Ca deposits in intestine were only detected in the FM group. Transcriptome profiling by microarray of livers showed dietary effects on several immune genes, and a panel of structural genes were up-regulated in the KM group, including cadherin and connexin. Up-regulation of genes encoding myosin heavy chain proteins was the main finding in skeletal muscle. Morphology examination by scanning electron microscopy and secondary structure by Fourier transform IR spectroscopy revealed more ordered and stable collagen architecture of the KM group. NEFA composition of skeletal muscle indicated altered metabolism of n-3, n-6 and SFA of the KM group. The results demonstrated that improved health and meat quality in Atlantic salmon fed krill meal were associated with up-regulation of immune genes, proteins defining muscle properties and genes involved in cell contacts and adhesion, altered fatty acid metabolism and fat deposition, and improved gut health and collagen structure., This work was funded by Aker Biomarine Antarctic AS, Oslo, Norway

The retina is a potential source of biomarkers for the detection of neurodegenerative diseases. Accumulation of phosphorylated tau (p-tau) in the brain is a pathological feature characteristic for Alzheimer's disease (AD) and primary tauopathies. In this study the presence of p-tau in the retina in relation to tau pathology in the brain was assessed. Post-mortem eyes and brains were collected through the Netherlands Brain Bank from donors with AD (n = 17), primary tauopathies (n = 8), α-synucleinopathies (n = 13), other neurodegenerative diseases including non-tau frontotemporal lobar degeneration (FTLD) (n = 9), and controls (n = 15). Retina cross-sections were assessed by immunohistochemistry using antibodies directed against total tau (HT7), 3R and 4R tau isoforms (RD3, RD4), and phospho-epitopes Ser202/Thr205 (AT8), Thr217 (anti-T217), Thr212/Ser214 (AT100), Thr181 (AT270), Ser396 (anti-pS396) and Ser422 (anti-pS422). Retinal tau load was compared to p-tau Ser202/Thr205 and p-tau Thr217 load in various brain regions. Total tau, 3R and 4R tau isoforms were most prominently present in the inner plexiform layer (IPL) and outer plexiform layer (OPL) of the retina and were detected in all cases and controls as a diffuse and somatodendritic signal. Total tau, p-tau Ser202/Thr205 and p-tau Thr217 was observed in amacrine and horizontal cells of the inner nuclear layer (INL). Various antibodies directed against phospho-epitopes of tau showed immunoreactivity in the IPL, OPL, and INL. P-tau Ser202/Thr205 and Thr217 showed significant discrimination between AD and other tauopathies, and non-tauopathy cases including controls. Whilst immunopositivity was observed for p-tau Thr212/Ser214, Thr181 and Ser396, there were no group differences. P-tau Ser422 did not show any immunoreactivity in the retina. The presence of retinal p-tau Ser202/Thr205 and Thr217 correlated with Braak stage for NFTs and with the presence of p-tau Ser202/Thr205 in hippocampus and cortical brain regions. Depending on the phospho-epitope, p-tau in the retina is a potential biomarker for AD and primary tauopathies.

This chapter explores the relation between education and meaning in life. People experience meaning in life when they (a) can make sense of their life and the(ir) world, (b) have purpose in life, and (c) experience significance and that they matter. The chapter describes how family life and parental upbringing, as well as students’ participation in schools and teachers’ education, can make positive and unique contributions to children’s (future) meaning in life. It concludes that parents and teachers should open the complex world to help children find their way, present a meaning framework that provides a standpoint from which to evaluate what is significant while also giving sufficient freedom to engage with other views on the good life, and develop relationships with children that foster their feelings that they matter while at the same time instilling a desire and sense of responsibility to matter to others.

The preliminary review of 150 images of watercraft in Persian manuscript paintings from the 14th to the 19th centuries reveals the contextual environment of these much-maligned images of seafaring. Nautical researchers rarely cite Persian paintings, but availability of digital facsimiles of Persian manuscripts online has improved access to a large corpus of images allowing close exami­nation and comparisons. This study demonstrates the potential of the corpus of watercraft images in Persian manuscripts and shows how these paintings may be interpreted more as illustrations of seafaring culture rather than detailed depictions of nautical technology. La relecture de 150 images d’embarcations apparaissant dans des peintures des manuscrits persans du xive au xixe siècle révèle l’environnement contextuel de ces images tant décriées de la navigation. Les chercheurs en histoire maritime citent rarement les peintures persanes, mais la disponibilité en ligne de fac-similés numériques de manuscrits persans a amélioré l’accès à un vaste corpus d’images permettant réexamens et comparaisons approfondies. Cette étude met en évidence le potentiel du corpus d’images d’embarcations dans les manuscrits persans et montre comment ces peintures peuvent être interprétées davantage comme des illustrations de la culture maritime que comme des représentations détaillées de la technologie nautique.

The present study evaluated the effects of increasing the dietary levels of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) in Atlantic salmon (Salmo salar) reared in sea cages, in terms of growth performance, welfare, robustness, and overall quality. Fish with an average starting weight of 275 g were fed one of four different diets containing 10, 13, 16, and 35 g/kg of EPA and DHA (designated as 1.0%, 1.3%, 1.6%, and 3.5% EPA and DHA) until they reached approximately 5 kg. The 3.5% EPA and DHA diet showed a significantly beneficial effect on growth performance and fillet quality compared with all other diets, particularly the 1% EPA and DHA diet. Fish fed the diet containing 3.5% EPA and DHA showed 400-600 g higher final weights, improved internal organ health scores and external welfare indicators, better fillet quality in terms of higher visual colour score and lower occurrence of dark spots, and higher EPA and DHA content in tissues at the end of the feeding trial. Moreover, fish fed the 3.5% EPA and DHA diet showed lower mortality during a naturally occurring cardiomyopathy syndrome outbreak, although this did not reach statistical significance. Altogether, our findings emphasise the importance of dietary EPA and DHA to maintain good growth, robustness, welfare, and fillet quality of Atlantic salmon reared in sea cages.

Contains fulltext : 271404.pdf (Publisher’s version ) (Open Access) Visual neuroprostheses are a promising approach to restore basic sight in visually impaired people. A major challenge is to condense the sensory information contained in a complex environment into meaningful stimulation patterns at low spatial and temporal resolution. Previous approaches considered task-agnostic feature extractors such as edge detectors or semantic segmentation, which are likely suboptimal for specific tasks in complex dynamic environments. As an alternative approach, we propose to optimize stimulation patterns by end-to-end training of a feature extractor using deep reinforcement learning agents in virtual environments. We present a task-oriented evaluation framework to compare different stimulus generation mechanisms, such as static edge-based and adaptive end-to-end approaches like the one introduced here. Our experiments in Atari games show that stimulation patterns obtained via task-dependent end-to-end optimized reinforcement learning result in equivalent or improved performance compared to fixed feature extractors on high difficulty levels. These findings signify the relevance of adaptive reinforcement learning for neuroprosthetic vision in complex environments. 16 p.

Due to a limited access to marine raw materials from capture fisheries, Atlantic salmon feeds are currently based on mainly plant ingredients (75%) while only 25% come from traditional marine ingredients including marine fish meal and fish oil. Thus, current feeds contain less of the essential omega-3 fatty acids. The aim of the study was to assess the impact of different omega-3 levels in fish feed on intestinal barrier and transporting functions of Atlantic salmon freshwater and seawater smolts. Atlantic salmon were fed three levels of omega-3 (2, 1 and 0.5%) and fish performance was followed through smoltification and the subsequent seawater acclimation. Intestinal barrier and transporting functions were assessed using Ussing chamber methodology and combined with transcript analysis of tight junction related proteins and ion transporters. A linear decrease in growth was observed with decreasing omega-3 levels. Low (0.5%) inclusion of omega-3 impaired the barrier function of the proximal intestine compared to 2% inclusion. Further, low levels of omega-3 decrease the transepithelial electrical potential across the epithelium indicating disturbed ion transport. It can be concluded that low dietary levels of omega-3 impair somatic growth and intestinal function of Atlantic salmon.