140 results on '"Shan, Chun"'
Search Results
2. Cadmium (Cd) exposure through Hyphantria cunea pupae reduces the parasitic fitness of Chouioia cunea: A potential risk to its biocontrol efficiency1
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Shan-chun YAN, Hong-fei WU, Lin ZHENG, Ming-tao TAN, and Dun JIANG
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Food Animals ,Ecology ,Animal Science and Zoology ,Plant Science ,Agronomy and Crop Science ,Biochemistry ,Food Science - Published
- 2023
3. A rapid multiplication system for ‘Candidatus Liberibacter asiaticus’ through regeneration of axillary buds in vitro
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LEI Tian-gang, HE Yong-rui, ZOU Xiu-ping, WANG Xue-feng, FU Shi-min, PENG Ai-hong, XU Lan-zhen, YAO Li-xiao, CHEN Shan-chun, and ZHOU Chang-yong
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Food Animals ,Ecology ,Animal Science and Zoology ,Plant Science ,Agronomy and Crop Science ,Biochemistry ,Food Science - Published
- 2022
4. Sociocultural aspect of care is definitely part of the 'problem': Developing preclinical students’ cross-cultural care competence through problem-based learning
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Peih-ying Lu and Anna Shan Chun Hsu
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Increasing diversity issues have posed challenges on pedagogical strategies of medical education, particularly in the post-pandemic era. Medical students are not only expected to have essential medical skills, but also be equipped with the abilities to stay attuned to the sociocultural needs of diverse patient groups. Providing students safe environments to hone these abilities is essential in helping them prepare for future patient encounters in the clinical setting. This study adopted mixed methods to explore the effectiveness of integrating issues on cross-cultural care competence (CCC) into problem-based learning (PBL) to enhance medical students’ CCC preparedness. With bases in constructivism and social cognitive learning theories, and drawing from Bloom’s taxonomy and the Conscious-Competence model in the development of adaptive expertise, this article included discussions of students’ and tutors’ perceptions of the effectiveness of integrating CCC issues into problem-based learning (PBL) in a Taiwanese medical school. We incorporated into PBL scenarios diversity issues students identified as being less prepared for in a previous study. For quantitative analysis, undergraduate medical students completed pre- and post-PBL questionnaires (pre =124, post = 239) and 24 tutors completed a tutor version of pre-PBL questionnaire. For qualitative analysis, we conducted two student focus groups (n = 8) and 12 individual tutor interviews. Scripts were transcribed, coded, and analyzed using inductive thematic analysis. Quantitative results revealed students generally considered CCC-integrated PBL to be effective in providing them with learning experiences to better understand diversity issues and preparing them for clinical learning. From interviews and focus groups, we further identified four themes: awareness raising- CCC topics in medical training; students’ engagement in CCC-issues- reasons affecting participation; tutors’ concerns- competence in facilitation of CCC learning; and competition in a crowded curriculum. These themes showed that participation in CCC-integrated PBL sessions can raise students’ awareness of sociocultural aspects, biases, stereotypes, diverse cultural groups’ healthcare needs and CCC issues. However, there are still gaps to fill including insufficient student engagement, tutors’ own competence (or capabilities) in addressing CCC, and inadequate time. In conclusion, strategically integrating CCC into PBL provide opportunities that allow students to raise awareness of the impact patients’ diverse backgrounds have on health care. Nevertheless, it is pivotal to address gaps in tutors’ perceptions and students’ learning experiences to design curricular content that can broaden students’ adaptive expertise and sensitivity to diverse patient needs.
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- 2023
5. Additional file 1 of Comparative study on epidemiological and etiological characteristics of patients with acute diarrhea with febrile or non-febrile symptoms in China
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Wang, Tao, Wang, Gang, Shan, Chun-Xi, Sun, Yan-Qun, Ren, Xiang, Yu, Lin-Jie, Wang, Yi-Fei, Lin, Sheng-Hong, Zhang, Xiao-Ai, Li, Hao, Zhang, Cui-Hong, Geng, Meng-Jie, Yang, Wei-Zhong, Wang, Li-Ping, Liu, Wei, and Fang, Li-Qun
- Abstract
Additional file 1. The Chinese Centers for Disease Control and Prevention (CDC) Etiology of Diarrhea Surveillance Study Team.
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- 2023
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6. Additional file 2 of Comparative study on epidemiological and etiological characteristics of patients with acute diarrhea with febrile or non-febrile symptoms in China
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Wang, Tao, Wang, Gang, Shan, Chun-Xi, Sun, Yan-Qun, Ren, Xiang, Yu, Lin-Jie, Wang, Yi-Fei, Lin, Sheng-Hong, Zhang, Xiao-Ai, Li, Hao, Zhang, Cui-Hong, Geng, Meng-Jie, Yang, Wei-Zhong, Wang, Li-Ping, Liu, Wei, and Fang, Li-Qun
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Additional file 2. Supplementary methods.
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- 2023
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7. Additional file 2 of Comparative study on epidemiological and etiological characteristics of patients with acute diarrhea with febrile or non-febrile symptoms in China
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Wang, Tao, Wang, Gang, Shan, Chun-Xi, Sun, Yan-Qun, Ren, Xiang, Yu, Lin-Jie, Wang, Yi-Fei, Lin, Sheng-Hong, Zhang, Xiao-Ai, Li, Hao, Zhang, Cui-Hong, Geng, Meng-Jie, Yang, Wei-Zhong, Wang, Li-Ping, Liu, Wei, and Fang, Li-Qun
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Additional file 2. Supplementary methods.
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- 2023
- Full Text
- View/download PDF
8. Analysis of factors influencing air quality in different periods during COVID- 19: A case study of Tangshan, China
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Wu, Wen-Lu, Shan, Chun-Yan, Liu, Jing, Zhao, Jing-Lin, and Long, Jin-Yun
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difference-in-differences analysis ,backward trajectory cluster ,meteorological factors ,Health, Toxicology and Mutagenesis ,Public Health, Environmental and Occupational Health ,COVID-19 ,anthropogenic factors ,air quality - Abstract
Since the outbreak of COVID-19, China has experienced the Level I, Level II, and Level III responses to the epidemic, with different measures have an impact on air quality in difference periods. This study aimed to analyze the main factors influencing air quality in three different periods during COVID-19 in Tangshan: the COVID-19 period, the Level I response period, and the Spring Festival period. Here, we used comparative analysis and difference-in-differences (DID) method to explore differences in air quality. During COVID-19, the air quality index (AQI) and the concentrations of six conventional air pollutants (PM2.5, PM10, SO2, NO2, CO, and O3-8h) decreased significantly compared to 2017–2019. Air quality improved may be the result of industry closures not related to livelihoods during COVID-19 in 2020. For the Level I response period, multiple linear regression (MLR) models were used to quantify the impact of COVID-19 control measures on AQI, and it was shown that the measures reduced the average AQI by 29.07%, 31.43%, and 20.04% in February, March, and April 2020, respectively. During the Spring Festival, the concentrations of the above-mentioned six pollutants were significantly higher than those in 2019 and 2021 as there were two heavy pollution episodes in 2020, and the possible pollutant sources were local emissions and short-distance transportation. As for the further improvement of air quality, it is necessary to take strict measures to prevent and control air pollution while paying attention to meteorological factors.
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- 2022
9. Altered effective connectivity in the emotional network induced by immersive virtual reality rehabilitation for post-stroke depression
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Wu, Jia-Jia, Zheng, Mou-Xiong, Hua, Xu-Yun, Wei, Dong, Xue, Xin, Li, Yu-Lin, Xing, Xiang-Xin, Ma, Jie, Shan, Chun-Lei, and Xu, Jian-Guang
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Behavioral Neuroscience ,Psychiatry and Mental health ,Neuropsychology and Physiological Psychology ,Neurology ,Biological Psychiatry - Abstract
Post-stroke depression (PSD) is a serious complication of stroke that significantly restricts rehabilitation. The use of immersive virtual reality for stroke survivors is promising. Herein, we investigated the effects of a novel immersive virtual reality training system on PSD and explored induced effective connectivity alterations in emotional networks using multivariate Granger causality analysis (GCA). Forty-four patients with PSD were equally allocated into an immersive-virtual reality group and a control group. In addition to their usual rehabilitation treatments, the participants in the immersive-virtual reality group participated in an immersive-virtual reality rehabilitation program, while the patients in the control group received 2D virtual reality rehabilitation training. The Hamilton Depression Rating Scale, modified Barthel Index (MBI), and resting-state functional magnetic resonance imaging (rsfMRI) data were collected before and after a 4-week intervention. rsfMRI data were analyzed using multivariate GCA. We found that the immersive virtual reality training was more effective in improving depression in patients with PSD but had no statistically significant improvement in MBI scores compared to the control group. The GCA showed that the following causal connectivities were strengthened after immersive virtual reality training: from the amygdala, insula, middle temporal gyrus, and caudate nucleus to the dorsolateral prefrontal cortex; from the insula to the medial prefrontal cortex; and from the thalamus to the posterior superior temporal sulcus. These causal connectivities were weakened after treatment in the control group. Our results indicated the neurotherapeutic use of immersive virtual reality rehabilitation as an effective non-pharmacological intervention for PSD; the alteration of causal connectivity in emotional networks might constitute the neural mechanisms underlying immersive-virtual reality rehabilitation in PSD.
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- 2022
10. Strategy of complex carbides in microalloyed 4Mn steels processed by quenching and austenite reversion
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Shao-Lun Lu, Shan-Chun Yang, Kangying Zhu, Yi-Sheng Chen, Julie M. Cairney, Chun-Ming Lin, and Hung-Wei Yen
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Mechanics of Materials ,Mechanical Engineering ,General Materials Science - Published
- 2023
11. On Bertrand Russell’s Enlightening Thought
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Shan Chun
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Literature ,Philosophy ,business.industry ,Criticism ,business - Abstract
Bertrand Russell was a renowned thinker who has exerted great influence over the Western intellectual circles of the 20th century. In particular, his criticism and reflections on Western religious ...
- Published
- 2021
12. A Trigonometric Projection Method for Overcoming High Intensity Heart Rate Caused Waveform Deformation in Electrocardiogram Biometrics
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Tsu-Wang Shen and Shan-Chun Chang
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021110 strategic, defence & security studies ,Mean squared error ,Biometrics ,0211 other engineering and technologies ,Biomedical Engineering ,02 engineering and technology ,General Medicine ,Signal ,Displacement (vector) ,Upsampling ,0202 electrical engineering, electronic engineering, information engineering ,Curve fitting ,Waveform ,020201 artificial intelligence & image processing ,Projection (set theory) ,Algorithm ,Mathematics - Abstract
Purpose Although electrocardiogram (ECG) has been proven as a biometric for human identification, applying biometric technology remains challenging with diverse heart rate circumstances in which high intensity heart rate caused waveform deformation may not be known in advance when ECG templates are registered. Methods A calibration method that calculates the ratio of the length of an unidentified electrocardiogram signal to the length of an electrocardiogram template is proposed in this paper. Next, the R peak is used as an axis anchor point of a trigonometric projection (TP) to attain the displacement value. Finally, the unidentified ECG signal is calibrated according to the generated trigonometric value, which corresponds to the trigonometric projection degree of the ratio and the attained displacement measurement. Results The results reveal that the proposed method provides superior overall performance compared with that of the conventional downsampling method, based on the percentage root mean square difference (PRD), correlation coefficients, and mean square error (MSE). Conclusion The curve fitting equation directly maps from the heart rate levels to the TP degree without prior registration information. The proposed ECG calibration method offers a more robust system against heart rate interference when conducting ECG identification.
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- 2021
13. A Trusted NUMFabric Algorithm for Congestion Price Calculation at the Internet-of-Things Datacenter
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Guoqiang Deng, Shan Chun, Xiaolong Chen, and Hao Liu
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Computer science ,business.industry ,Modeling and Simulation ,business ,Internet of Things ,Software ,Computer Science Applications ,Computer network - Published
- 2021
14. Piezo1 suppression reduces demyelination after intracerebral hemorrhage
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Jie Qu, Hang-Fan Zong, Yi Shan, Shan-Chun Zhang, Wei-Ping Guan, Yang Yang, and Heng-Li Zhao
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Developmental Neuroscience - Published
- 2022
15. Software Crucial Functions Ranking and Detection in Dynamic Execution Sequence Patterns
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Guoyan Huang, Munawar Hussain, Jiadong Ren, Bing Zhang, and Shan Chun
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Software network ,Computer Networks and Communications ,Computer science ,business.industry ,020207 software engineering ,02 engineering and technology ,computer.software_genre ,01 natural sciences ,Computer Graphics and Computer-Aided Design ,Sequence pattern ,010305 fluids & plasmas ,Ranking (information retrieval) ,Software ,Artificial Intelligence ,0103 physical sciences ,0202 electrical engineering, electronic engineering, information engineering ,Decision function ,Data mining ,business ,computer ,Sequence (medicine) - Abstract
Because of the sequence and number of calls of functions, software network cannot reflect the real execution of software. Thus, to detect crucial functions (DCF) based on software network is controversial. To address this issue, from the viewpoint of software dynamic execution, a novel approach to DCF is proposed in this paper. It firstly models, the dynamic execution process as an execution sequence by taking functions as nodes and tracing the stack changes occurring. Second, an algorithm for deleting repetitive patterns is designed to simplify execution sequence and construct software sequence pattern sets. Third, the crucial function detection algorithm is presented to identify the distribution law of the numbers of patterns at different levels and rank those functions so as to generate a decision-function-ranking-list (DFRL) by occurrence times. Finally, top-k discriminative functions in DFRL are chosen as crucial functions, and similarity the index of decision function sets is set up. Comparing with the results from Degree Centrality Ranking and Betweenness Centrality Ranking approaches, our approach can increase the node coverage to 80%, which is proven to be an effective and accurate one by combining advantages of the two classic algorithms in the experiments of different test cases on four open source software. The monitoring and protection on crucial functions can help increase the efficiency of software testing, strength software reliability and reduce software costs.
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- 2020
16. Alizarin as a New Activator of the Aryl Hydrocarbon Receptor Signaling Pathway
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Yin-Che Lu, Yu-Hsiang Kuan, Chih-Yi Lin, Yu-Ting Chou, Shan-Chun Chen, Guan-Lun Gao, Chiang Wei Hsu, and Jyan-Gwo Joseph Su
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Pharmacology ,Complementary and alternative medicine ,Drug Discovery ,Plant Science ,General Medicine - Abstract
Alizarin (1,2-dihydroxyanthraquinone) is a natural red dye extracted from the roots of Rubia cordifolia L. (family Rubiaceae). Alizarin has been used as a biological red stain for calcium. The aryl hydrocarbon receptor (AhR) has critical roles in multiple physiological pathways. This study aimed to determine whether alizarin is an unreported ligand of AhR. In the present study, we investigated the effects on cytochrome P450 (CYP) 1A1 mRNA, protein expression, AhR nuclear translocation, aryl hydrocarbon response element (AHRE) reporter activity, and AhR-specific antagonist following alizarin treatment of cells of the human hepatoma cell line, HepG2, and murine hepatoma cell line, Hepa-1c1c7. Alizarin induced CYP1A1 mRNA and protein expression in HepG2 and Hep-1c1c7 cells. Such induction was not present in C4 (B13NBii1) cells, which are AhR signal deficient, C12 (B15ECiii2) cells, which reduce AhR protein levels. The alizarin-induced responses were blocked by CH-223191, which is an AhR antagonist. Alizarin, the same as with the AhR ligand, induced the nuclear localization of AhR, as well as stimulated the transcriptional activity of AHRE. The results of this study suggest that alizarin is an AhR agonist.
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- 2022
17. Medical students’ perceptions of their preparedness to care for LGBT patients in Taiwan: Is medical education keeping up with social progress?
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Peih-Ying Lu, Anna Shan Chun Hsu, Alexander Green, and Jer-Chia Tsai
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Sexual and Gender Minorities ,Students, Medical ,Multidisciplinary ,Education, Medical ,Taiwan ,Humans ,Female ,Curriculum ,Health Promotion ,Transgender Persons - Abstract
Introduction Integrating training on health equity of sexual and gender minorities (SGM) in medical education has been challenging globally despite emphasis on the need for medical students to develop competence to provide adequate care for diverse patient groups. This study elicits Taiwanese medical students’ perceptions of their values and preparedness to care for Lesbian, Gay, Bisexual, or Transgender (LGBT) patients using a qualitative approach that considers broader societal changes, and more focused topics such as the provision of relevant training in medical education. Methods Eighty-nine medical students/trainees from two southern Taiwanese medical schools (one public and one private) participated in focus groups (n = 70) and individual interviews (n = 19). Qualitative analysis was conducted using inductive thematic analysis. Results Participants (i) expressed wide social acceptance and openness toward LGBT individuals, but were unsure of ways to communicate with LGBT patients; (ii) confirmed that stigmatization and biases might be developed during their training; (iii) recognized gender stereotypes could have negative impacts on clinical reasoning; (iv) considered themselves prepared to care for LGBT patients, yet equated non-discriminatory attitudes to preparedness; (v) acknowledged a lack of relevant professional skills; (vi) implicated curriculum did not address LGBT issues systematically and explicitly. Conclusion This study has identified the insufficiencies of current medical training and inadequate preparedness of medical students/trainees to provide better care for LGBT patients. It provides insights for medical educators to design and implement effective medical curriculum and training, and faculty development programs to equip medical students/trainees with self-awareness and competencies to more readily provide holistic care for SGM, in keeping up with social progress, and promote health equity for a more diverse patient population.
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- 2022
18. A Novel Algorithm for Identifying Key Function Nodes in Software Network Based on Evidence Theory
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Jun Dong, Jiadong Ren, Xiaolin Zhao, Jiaxin Liu, Qian Wang, and Shan Chun
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Software network ,Computer Networks and Communications ,Computer science ,media_common.quotation_subject ,02 engineering and technology ,Complex network ,computer.software_genre ,01 natural sciences ,Computer Graphics and Computer-Aided Design ,010305 fluids & plasmas ,Software fault detection ,Artificial Intelligence ,0103 physical sciences ,0202 electrical engineering, electronic engineering, information engineering ,Key (cryptography) ,020201 artificial intelligence & image processing ,Data mining ,Function (engineering) ,computer ,Software ,media_common - Abstract
In a software network system, it is of great significance to identify key functions for software fault detection and maintenance. In order to better understand the characteristics and internal structure of software, a key Node Discovery algorithm based on Evidence Theory called NDET is proposed in this paper. First, the software complex network model is constructed according to the execution process of the software. Based on the Dempster-Shafer evidence theory (D-S evidence theory), the discernment frame is formed, the maximum and minimum values of the network degree and strength are determined. Second, the Basic Probability Assignment (BPA) of each node degree is calculated by considering the node degree distribution ratio value. Third, based on Dempster’s rule of combination, the evidential centrality of the node itself and the fluctuation value of the node influenced by neighbor nodes are considered for the key measurement. Finally, by using the Susceptible–Infected–Recovered (SIR) model to simulate the spreading process on real software networks, the performance of NDET is evaluated. Experiment results verify the validity and accuracy of NDET for identifying key function nodes in software.
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- 2019
19. Protist.guru: A Comparative Transcriptomics Database for Protists
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Erielle Marie Fajardo Villanueva, Peng Ken Lim, Jolyn Jia Jia Lim, Shan Chun Lim, Pei Yi Lau, Kenny Ting Sween Koh, Emmanuel Tan, Ryanjit Singh Kairon, Wei An See, Jian Xiang Liao, Ker Min Hee, Varsheni Vijay, Ishani Maitra, Chong Jun Boon, Kevin Fo, Yee Tat Wang, Ryan Jaya, Li Anne Hew, Yong Yee Lim, Wei Quan Lee, Zhi Qi Lee, Herman Foo, Adriana Lopes dos Santos, Marek Mutwil, School of Biological Sciences, and Asian School of the Environment
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Structural Biology ,Protist ,Gene Expression Profiling ,Databases, Genetic ,Biological sciences [Science] ,Eukaryota ,Expression ,Sequence Analysis, DNA ,Transcriptome ,Molecular Biology - Abstract
During the last few decades, the study of microbial ecology has been enabled by molecular and genomic data. DNA sequencing has revealed the surprising extent of microbial diversity and how microbial processes run global ecosystems. However, significant gaps in our understanding of the microbial world remain, and one example is that microbial eukaryotes, or protists, are still largely neglected. To address this gap, we used gene expression data from 17 protist species to create protist.guru: an online database equipped with tools for identifying co-expressed genes, gene families, and co-expression clusters enriched for specific biological functions. Here, we show how our database can be used to reveal genes involved in essential pathways, such as the synthesis of secondary carotenoids in Haematococcus lacustris. We expect protist.guru to serve as a valuable resource for protistologists, as well as a catalyst for discoveries and new insights into the biological processes of microbial eukaryotes. AVAILABILITY: The database and co-expression networks are freely available from http://protist.guru/. The expression matrices and sample annotations are found in the supplementary data. Submitted/Accepted version
- Published
- 2022
20. Magnesium isoglycyrrhizinate ameliorates high fructose-induced liver fibrosis in rat by increasing miR-375-3p to suppress JAK2/STAT3 pathway and TGF-β1/Smad signaling
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Hong-Jiang Xu, Xiao-juan Zhao, Shui-Juan Wang, Shan-Chun Wang, Rui-qing Jiao, Pan Ying, Ling-Dong Kong, Hong-Mei Gu, Qiang Xu, and Yan-Zi Yang
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0301 basic medicine ,Pharmacology ,biology ,Kinase ,Chemistry ,Cell ,General Medicine ,SMAD ,Transfection ,Article ,03 medical and health sciences ,030104 developmental biology ,0302 clinical medicine ,medicine.anatomical_structure ,Mir-375 ,030220 oncology & carcinogenesis ,biology.protein ,Cancer research ,STAT protein ,medicine ,Pharmacology (medical) ,STAT3 ,Transforming growth factor - Abstract
Increasing evidence has demonstrated that excessive fructose intake induces liver fibrosis. Epithelial–mesenchymal transition (EMT) driven by transforming growth factor-β1 (TGF-β1)/mothers against decapentaplegic homolog (Smad) signaling activation promotes the occurrence and development of liver fibrosis. Magnesium isoglycyrrhizinate is clinically used as a hepatoprotective agent to treat liver fibrosis, but its underlying molecular mechanism has not been identified. Using a rat model, we found that high fructose intake reduced microRNA (miR)-375-3p expression and activated the janus-activating kinase 2 (JAK2)/signal transducer and activator of transcription 3 (STAT3) cascade and TGF-β1/Smad signaling, which is consistent with the EMT and liver fibrosis. To further verify these observations, BRL-3A cells and/or primary rat hepatocytes were exposed to high fructose and/or transfected with a miR-375-3p mimic or inhibitor or treated with a JAK2 inhibitor, and we found that the low expression of miR-375-3p could induce the JAK2/STAT3 pathway to activate TGF-β1/Smad signaling and promote the EMT. Magnesium isoglycyrrhizinate was found to ameliorate high fructose-induced EMT and liver fibrosis in rats. More importantly, magnesium isoglycyrrhizinate increased miR-375-3p expression to suppress the JAK2/STAT3 pathway and TGF-β1/Smad signaling in these animal and cell models. This study provides evidence showing that magnesium isoglycyrrhizinate attenuates liver fibrosis associated with a high fructose diet.
- Published
- 2018
21. Inducible defense responses in Populus alba berolinensis to Pb stress
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Shan-chun Yan, Dun Jiang, Xiao-wen Dong, and Y.-y. Wang
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0106 biological sciences ,chemistry.chemical_classification ,Protease ,medicine.medical_treatment ,Trypsin inhibitor ,Flavonoid ,Plant Science ,010501 environmental sciences ,01 natural sciences ,Polyphenol oxidase ,chemistry.chemical_compound ,Horticulture ,Enzyme ,chemistry ,medicine ,Lignin ,Sugar ,010606 plant biology & botany ,0105 earth and related environmental sciences ,Woody plant - Abstract
To better understand the effects of heavy metal stress on inducible defenses of woody plants, contents of nutritional substances and secondary metabolites, plus the activities of defense enzymes and protease inhibitors in the leaves of Populus alba berolinensis seedlings that were planted in either non-contaminated soil (control) or Pb-contaminated soil (at 300, 500 and 700 mg/kg) were studied. Our results showed that protein and soluble sugar contents in leaves 30–50 days after the Pb stress were significantly lower than those in the control group in a dose-dependent manner, whereas the lignin and flavonoid contents were significantly higher. Polyphenol oxidase (PPO) and phenylalnine ammonialyase (PAL) activities in leaves were significantly enhanced by the low Pb concentration stress (300 mg/kg) for all three sampling dates (30, 40 and 50 days after the Pb treatments), while at the two higher Pb concentrations (500 and 700 mg/kg), PPO activities were always inhibited and PAL activities presented a tendency of “promoting first and then restraining” with the increase of exposure duration. The response patterns of trypsin inhibitor (TI) and chymotrypsin inhibitor (CI) activities to Pb stress were similar to that of PPO, and presented a “low-promotion, high-inhibition” effect of Pb concentrations in leaves. These results suggest that the inducible defense responses in P. alba berolinensis leaves to Pb stress depend on both the Pb concentrations and the exposure duration, and the low Pb concentration at 300 mg/kg seemed to induce the strongest defense responses in the poplar seedlings, much stronger than those at the higher Pb concentrations.
- Published
- 2018
22. Cyproterone acetate acts as a disruptor of the aryl hydrocarbon receptor
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Chih-Shou Chen, Yu-Ting Chou, Min-Cong Huang, Shan-Chun Chen, Guan-Lun Gao, Dong-Ru Ho, Chih-Yi Lin, Jyan-Gwo Joseph Su, and Wen-Ya Kao
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Transcriptional Activation ,0301 basic medicine ,Agonist ,Cell biology ,Cell Survival ,medicine.drug_class ,Urology ,Science ,Response element ,Antineoplastic Agents ,Gene mutation ,Cytoplasmic receptor ,Article ,Mice ,03 medical and health sciences ,chemistry.chemical_compound ,Medical research ,0302 clinical medicine ,Glucocorticoid receptor ,Cell Line, Tumor ,Neoplasms ,Cytochrome P-450 CYP1A1 ,medicine ,Animals ,Humans ,heterocyclic compounds ,Cyproterone Acetate ,Multidisciplinary ,biology ,Chemistry ,Cyproterone acetate ,respiratory system ,Aryl hydrocarbon receptor ,respiratory tract diseases ,Gene Expression Regulation, Neoplastic ,030104 developmental biology ,Receptors, Aryl Hydrocarbon ,Endocrine disruptor ,030220 oncology & carcinogenesis ,cardiovascular system ,biology.protein ,Cancer research ,Medicine ,Cell signalling - Abstract
Prostate cancer is a major cause of death in males. Cyproterone acetate (CPA), the steroidal anti-androgen for part of androgen deprivation therapy, may block the androgen-receptor interaction and then reduce serum testosterone through its weak anti-gonadotropic action. In addition to CPA inducing hepatitis, CPA is known to cause liver tumors in rats also. Aryl hydrocarbon receptor (AhR) is a cytoplasmic receptor and regulates multiple physiological functions. CYP1A1 is an AhR-targeted gene. We found that CPA induced CYP1A1 expression, transcriptional activity of the aryl hydrocarbon response element (AHRE), and the nuclear localization of AhR in mouse Hepa-1c1c7 cells. However, CPA suppressed CYP1A1 mRNA expression and the transcriptional activity of AHRE in human HepG2 and MCF7 cells, and also decreased AhR ligand-induced CYP1A1 protein expression and transcriptional activity of AHRE in HepG2 cells. In summary, CPA is an AhR agonist in mouse cells, but an AhR antagonist in human cells. Accordingly, CPA potentially plays a role as an endocrine disruptor of the AhR. This study helps us to understand why CPA induces acute hepatitis, gene mutation, and many other side effects. In addition, it may trigger further studies investigating the relationships between CPA, glucocorticoid receptor and castration-resistant prostate cancer in the future.
- Published
- 2021
23. [Value of molecular imaging in diagnosis and differential diagnosis of cerebral amyloid angiopathy]
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Shan-Chun, Zhang, Yan-Chang, Shang, Ke, Li, Xuan, Sun, Bo, Zhou, Li-Ping, Fu, Bai-Xuan, Xu, Jian-Jun, Jia, Zhen-Fu, Wang, and Wei-Ping, Wu
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Diagnosis, Differential ,Cerebral Amyloid Angiopathy ,Amyloid beta-Peptides ,Aniline Compounds ,Brain ,Humans ,Molecular Imaging - Published
- 2021
24. [Transcriptome analysis of 'Langmei' fruits and key enzyme genes structure and function prediction involved in citric acid biosynthesis]
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O U, Jin-Mei, Yang, Xu, Shan, Chun-Miao, Zhang, Sheng-Xiang, Shi, Yuan-Yuan, W U, Jia-Wen, Huang, Lu-Qi, and Wang, Rui
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Fruit ,Gene Expression Profiling ,High-Throughput Nucleotide Sequencing ,Transcriptome ,Citric Acid - Abstract
Prunus mumequot;Langmeiquot; is a relict tree species, which fruit has good medicinal value. To understand the biosynthesis pathway of citric acid, the Illumina HiSeq XTen high-throughput sequencing technology was used to get the transcriptome fromquot;Langmeiquot;. A total of 38 936 unigenes were obtained by assembling the fruit transcripts, of which 28 311 unigenes were successfully annotated in public databases, 15 193 unigenes were mapped to 265 KEGG metabolic pathways, and 18 908 unigenes were classified into 59 GO functional subclasses, 103 unigenes encoding 15 key enzymes involved in citric acid synthesis pathway were identified and analyzed. The structural model of citrate synthetase inquot;Langmeiquot; showed that it was a homodimer and the secondary structure of each monomer was mainly composed of alpha helixes. Moreover, the residues in the active site of the citrate synthetase were highly conserved. This study provides a valuable resource for identifying candidate genes involved in the citric acid biosynthesis pathway, and will promote the development and sustainable utilization of genetic resources ofquot;Langmeiquot;.
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- 2020
25. Fungi.guru: Comparative genomic and transcriptomic resource for the fungi kingdom
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Jia Rong Moo, Wei Song Seetoh, Tong Ling Chan, Vanessa Lunardi, Cherlyn Xin’Er Chua, Riccardo Delli-Ponti, Zoe Hui Xin Chen, Marek Mutwil, Shan Chun Lim, Kenny Koh, Jace Koh, Rinta P. Reji, Tuck Choy Fong, Jonathan Wei Xiong Ng, Yuen Shan Lim, Ann Don Low, Natasha Cassandra Chee, Ryanjit Singh Kairon, Herman Foo, Irene Julca, Jolyn Jia Jia Lim, Dhira Anindya Putri, Nhi Le Uyen Nguyen, Ker Min Hee, Sriya Mulupuri, Margaret Xuan Zhao, Edbert Edric Rodrigues, Erielle Marie Fajardo Villanueva, Janice Wan Zhen Ng, and School of Biological Sciences
- Subjects
Pyricularia ,lcsh:Biotechnology ,Biophysics ,Expression ,Computational biology ,Secondary metabolite ,Biochemistry ,Database ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Structural Biology ,lcsh:TP248.13-248.65 ,Genetics ,medicine ,Gene family ,Gene ,030304 developmental biology ,ComputingMethodologies_COMPUTERGRAPHICS ,0303 health sciences ,Gliotoxin ,biology ,fungi ,Fungi ,Biological sciences [Science] ,food and beverages ,biology.organism_classification ,Co-expression ,Computer Science Applications ,Coprinopsis cinerea ,Metabolism ,chemistry ,030220 oncology & carcinogenesis ,Identification (biology) ,Gene function ,Function (biology) ,Biotechnology ,medicine.drug ,Research Article - Abstract
Graphical abstract, The fungi kingdom is composed of eukaryotic heterotrophs, which are responsible for balancing the ecosystem and play a major role as decomposers. They also produce a vast diversity of secondary metabolites, which have antibiotic or pharmacological properties. However, our lack of knowledge of gene function in fungi precludes us from tailoring them to our needs and tapping into their metabolic diversity. To help remedy this, we gathered genomic and gene expression data of 19 most widely-researched fungi to build an online tool, fungi.guru, which contains tools for cross-species identification of conserved pathways, functional gene modules, and gene families. We exemplify how our tool can elucidate the molecular function, biological process and cellular component of genes involved in various biological processes, by identifying a secondary metabolite pathway producing gliotoxin in Aspergillus fumigatus, the catabolic pathway of cellulose in Coprinopsis cinerea and the conserved DNA replication pathway in Fusarium graminearum and Pyricularia oryzae. The tool is available at www.fungi.guru.
- Published
- 2020
26. Sorafenib is an antagonist of the aryl hydrocarbon receptor
- Author
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Kuo-Liang Wei, Guan-Lun Gao, Yu-Ting Chou, Chih-Yi Lin, Shan-Chun Chen, Yi-Ling Chen, Hui Qin Choi, Chi-Chia Cheng, and Jyan-Gwo Joseph Su
- Subjects
Mice ,Carcinoma, Hepatocellular ,Receptors, Aryl Hydrocarbon ,Liver Neoplasms ,Cytochrome P-450 CYP1A1 ,Animals ,Sorafenib ,Ligands ,Toxicology - Abstract
Sorafenib is an orally administered inhibitor of several tyrosine protein kinases. Treatment with sorafenib induces autophagy, which may suppress the growth of hepatocellular carcinoma (HCC) and other cancers. Aryl hydrocarbon receptor (AhR) is activated by xenbiotics and is involved in detoxification, but also plays other physiological roles. The following results were obtained. ITE and β-NF are endogenous and synthetic AhR ligands, respectively. One μM sorafenib can strongly suppress baseline as well as 0.5 μM ITE- and 1 μM β-NF-induced transcriptional activity of the aryl hydrocarbon response element (AHRE) in both human and mouse cells. Cytochrome p450 (CYP) 1A1 is mainly transcribed by activated AhR. Sorafenib (2-15 μM) strongly and dose-dependently suppressed baseline as well as 2 μM ITE- and 10 μM β-NF-induced CYP1A1 mRNA and protein expression. Ligand-activated AhR translocates from the cytoplasm to the nucleus. While sorafenib was found to suppress AhR activity, the drug alone was able to induce AhR translocation into the nucleus. Sorafenib's antagonistic action on AhR was comparable to that of the known AhR antagonist CH-223191 in human liver and ovarian cell lines. In summary, we demonstrate that sorafenib is a potent AhR antagonist and likely endocrine disruptor of the AhR. Moreover, sorafenib offers potential benefit for diseases treatable through AhR suppression strategies. Further investigation is warranted into sorafenib's AhR antagonistic behavior.
- Published
- 2022
27. Fungi.guru: comparative genomic and transcriptomic database for the Fungi kingdom
- Author
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Ryan Kairon, Ann Don Low, Jonathan Wei Xiong Ng, Yuen Shan Lim, Dhira Anindya Putri, Rinta P. Reji, Jia Rong Moo, Natasha Cassandra Chee, Edbert Edric Rodrigues, Erielle Marie Fajardo Villanueva, Fong Tuck Choy, Kenny Koh Ting Sween, Vanessa Lunardi, Cherlyn Xin’Er Chua, Jolyn Jia Jia Lim, Margaret Xuan Zhao, Zoe Chen Hui Xin, Shan Chun Lim, Nhi Le Uyen Nguyen, Janice Wan Zhen Ng, Sriya Mulupuri, Tong Ling Chan, Marek Mutwil, Jace Koh, and Wei Song Seetoh
- Subjects
Pyricularia ,Database ,Gliotoxin ,Biology ,Secondary metabolite ,computer.software_genre ,biology.organism_classification ,Transcriptome ,Coprinopsis cinerea ,chemistry.chemical_compound ,chemistry ,medicine ,Gene family ,computer ,Gene ,Function (biology) ,medicine.drug - Abstract
The fungi kingdom is composed of eukaryotic heterotrophs, which are responsible for balancing the ecosystem and play a major role as decomposers. They also produce a vast diversity of secondary metabolites, which have antibiotic or pharmacological properties. However, our lack of knowledge of gene function in fungi precludes us from tailoring them to our needs and tapping into their metabolic diversity. To remedy this, we gathered genomic and gene expression data of 19 most widely-researched fungi to build a database, fungi.guru, which contains tools for cross-species identification of conserved pathways, functional gene modules, and gene families. We exemplify how our database can elucidate the molecular function, biological process and cellular component of genes involved in various biological processes, by identifying a secondary metabolite pathway producing gliotoxin in Aspergillus fumigatus, the catabolic pathway of cellulose in Coprinopsis cinerea and the conserved DNA replication pathway in Fusarium graminearum and Pyricularia oryzae. The database is available at www.fungi.guru.
- Published
- 2020
28. [The regulatory mechanism of Raf/MEK/ERK pathway on the rat cardiac hypertrophy induced by transverse aortic constriction]
- Author
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Dan-Ting, Fu, Jue, Tu, Yue-Qin, Cai, Zhao-Wei, Cai, Li-Zong, Zhang, Jing-Yan, Liu, Shan-Chun, Xu, and De-Jun, Wang
- Subjects
Rats, Sprague-Dawley ,MAP Kinase Signaling System ,Myocardium ,Animals ,Cardiomegaly ,Constriction ,Aorta ,Rats - Abstract
To investigate the mRNA, protein expression levels and the phosphorylation levels of key factors in rapidly accelerated fibrosarcoma/mitogen-activated protein kinase kinase/extracellular regulated protein kinases (Raf/MEK/ERK) pathway, and to clarify the regulatory function of Raf/MEK/ERK pathway in myocardial hypertrophy.Twenty SD rats were divided into sham-operated group and model group. The myocardial hypertrophy model was established by transverse aortic constriction (TAC). At 12 weeks after TAC, blood samples were collected from the submandibular vein, and the serum was separated to detect the content of N terminal pro B type natriuretic peptide (NT-proBNP). After that, the rats were subjected to echocardiography and hemodynamic measurement. Then the pathological changes of myocardial tissue were observed. And the levels of mRNA, protein expression and the phosphorylation of key factors in Raf/MEK/ERK pathway were detected in myocardial tissue.Compared with sham-operated group, left ventricular end-diastolic interventricular septal thickness (IVSd), left ventricular end-systolic interventricular septal thickness (IVSs), left ventricular end-diastolic posterior wall thickness (LVPWd) and left vebtricular end-systolic posterior wall thickness (LVPWs) in TAC model group were increased significantly (P<0.05,P<0.01), left ventricular end-systolic diameter (LVIDs) was decreased significantly (P<0.01), LV Mass and LW(LV Mass/Weight)were increased significantly (P<0.05, P<0.01). The levels of heart rate (HR), left ventricular pressure maximal rate of rise (+dp/dtmax), left ventricular pressure maximal rate of fall (-dp/dtmax) were decreased significantly (P<0.01). The serum level of NT-proBNP in TAC rat was increased significantly (P<0.01). The myocardial cells in TAC model group were arranged disorderly, myocardial cell hypertrophy, cytoplasm were increased significantly, and inflammatory cells infiltrated. A large amount of collagen fibers were deposited and large area of myocardial cells were stained blue in TAC rat. The expression levels of phospho-c-Raf (Ser259) and phospho-c-Raf (Ser338) in myocardial tissue were significantly increased (P<0.01), meanwhile the expression levels of phospho- MEK1/2(Ser217/Ser221) and phospho-ERK1/2 (Thr202/Tyr204) were also significantly increased (P<0.01).The regulatory role of Raf / MEK / ERK pathway in cardiac hypertrophy may be through the activation of phosphorylation of c-raf, MEK1, Mek2, ERK1 and ERK2 at specific sites.
- Published
- 2020
29. High Energy and High Conversion Efficiency 355 nm UV Laser
- Author
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张 鹏 Zhang Peng, 崔建丰 Cui Jian-feng, 李福玖 Li Fu-jiu, 岱 钦 Dai Qin, 张善春 Zhang Shan-chun, 邬小娇 Wu Xiao-jiao, and 李业秋 Li Ye-qiu
- Subjects
High energy ,Radiation ,Materials science ,business.industry ,Energy conversion efficiency ,Uv laser ,Optoelectronics ,Condensed Matter Physics ,business ,Electronic, Optical and Magnetic Materials - Published
- 2018
30. Corrigendum to 'Magnesium isoglycyrrhizinate blocks fructose-induced hepatic NF-κB/NLRP3 inflammasome activation and lipid metabolism disorder' [Eur. J. Pharmacol. 15 (2017) 809: 141–150]
- Author
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Ying Pan, Hong-Jiang Xu, Xiao-Juan Zhao, Hong-Mei Gu, Shan-Chun Wang, Shui-Juan Wang, Yan-Jing Zheng, Yan-Zi Yang, and Ling-Dong Kong
- Subjects
Pharmacology ,chemistry.chemical_compound ,Lipid Metabolism Disorder ,Chemistry ,NF-κB ,Fructose ,NLRP3 inflammasome activation ,Magnesium isoglycyrrhizinate - Published
- 2021
31. Identification and functional characterization of an odorant receptor in pea aphid, Acyrthosiphon pisum
- Author
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Ruibin Zhang, Yang Liu, Guirong Wang, and Shan-Chun Yan
- Subjects
0301 basic medicine ,Olfactory system ,media_common.quotation_subject ,Xenopus ,Insect ,General Biochemistry, Genetics and Molecular Biology ,03 medical and health sciences ,0302 clinical medicine ,Botany ,Gene expression ,medicine ,Ecology, Evolution, Behavior and Systematics ,media_common ,Aphid ,Olfactory receptor ,biology ,food and beverages ,biology.organism_classification ,Acyrthosiphon pisum ,Cell biology ,030104 developmental biology ,medicine.anatomical_structure ,Insect Science ,Heterologous expression ,Agronomy and Crop Science ,030217 neurology & neurosurgery - Abstract
The sensitive olfactory system is necessary for survival of insects. Odorant receptors (ORs) are located on the dendrites of olfactory receptor neurons and play a critical role in odor detection. Insect ORs are functionally analyzed via heterologous expression in a Xenopus oocyte system using a two-electrode voltage-clamp (TEVC) electrophysiological recording. Here, we have identified a novel OR in the pea aphid, Acyrthosiphon pisum, then we cloned and named it ApisOR4. We analyzed the ApisOR4 tissue expression patterns and found expression only in antennae tissues. Further functional analysis using TEVC revealed that ApisOR4 is broadly tuned to eight volatiles, which elicit electrophysiological response in pea aphid antennae. This study provides an initial functional analysis of aphid ORs and identifies candidate volatiles to be used in developing new strategies for aphid control.
- Published
- 2017
32. Magnesium isoglycyrrhizinate blocks fructose-induced hepatic NF-κB/NLRP3 inflammasome activation and lipid metabolism disorder
- Author
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Yan-Jing Zheng, Hong-Jiang Xu, Shan-Chun Wang, Shui-Juan Wang, Ling-Dong Kong, Hong-Mei Gu, Ying Pan, Xiao-Juan Zhao, and Yan-Zi Yang
- Subjects
Male ,0301 basic medicine ,Lipid Metabolism Disorder ,Inflammasomes ,Down-Regulation ,Inflammation ,Fructose ,Pharmacology ,Rats, Sprague-Dawley ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,NLR Family, Pyrin Domain-Containing 3 Protein ,medicine ,Animals ,Humans ,PPAR alpha ,Carnitine ,Liver injury ,Chemistry ,Kinase ,Metabolic disorder ,NF-kappa B ,NF-κB ,Hep G2 Cells ,Saponins ,Lipid Metabolism ,medicine.disease ,Triterpenes ,Rats ,030104 developmental biology ,Liver ,030220 oncology & carcinogenesis ,Tumor necrosis factor alpha ,medicine.symptom ,Sterol Regulatory Element Binding Protein 1 ,Signal Transduction ,medicine.drug - Abstract
Magnesium isoglycyrrhizinate as a hepatoprotective agent possesses immune modulation and anti-inflammation, and treats liver diseases. But its effects on immunological-inflammatory and metabolic profiles for metabolic syndrome with liver injury and underlying potential mechanisms are not fully understood. In this study, magnesium isoglycyrrhizinate alleviated liver inflammation and lipid accumulation in fructose-fed rats with metabolic syndrome. It also suppressed hepatic inflammatory signaling activation by reducing protein levels of phosphorylation of nuclear factor-kappa B p65 (p-NF-κB p65), inhibitor of nuclear factor kappa-B kinase α/β (p-IKKα/β) and inhibitor of NF-κB α (p-IκBα) as well as nucleotide-binding domain (NOD)-like receptor protein 3 (NLRP3), apoptosis-associated speck-like protein (ASC) and Caspase-1 in rats, being consistent with its reduction of interleukin-1β (IL-1β), tumor necrosis factor-α (TNF-α) and IL-6 levels. Furthermore, magnesium isoglycyrrhizinate modulated lipid metabolism-related genes characterized by up-regulating peroxisome proliferator-activated receptor-α (PPAR-α) and carnitine palmitoyl transferase-1 (CPT-1), and down-regulating sensor for fatty acids to control-1 (SREBP-1) and stearoyl-CoA desaturase 1 (SCD-1) in the liver of fructose-fed rats, resulting in the reduction of triglyceride and total cholesterol levels. These effective actions were further confirmed in fructose-exposed BRL-3A and HepG2 cells. The molecular mechanisms underpinning these observations suggest that magnesium isoglycyrrhizinate may inhibit NF-κB/NLRP3 inflammasome activation to reduce immunological-inflammatory response, which in turn may prevent liver lipid metabolic disorder and accumulation under high fructose condition. Thus, blockade of NF-κB/NLRP3 inflammasome activation and lipid metabolism disorder by magnesium isoglycyrrhizinate may be the potential therapeutic approach for improving fructose-induced liver injury with metabolic syndrome in clinic.
- Published
- 2017
33. Oxidation resistance and mechanical properties of Zr–Si–N coatings with cyclic gradient concentration
- Author
-
Shan-Chun Chang, Li-Chun Chang, and Yung-I Chen
- Subjects
010302 applied physics ,Materials science ,Annealing (metallurgy) ,Metallurgy ,Direct current ,Oxide ,Modulus ,02 engineering and technology ,Surfaces and Interfaces ,General Chemistry ,021001 nanoscience & nanotechnology ,Condensed Matter Physics ,01 natural sciences ,Surfaces, Coatings and Films ,Amorphous solid ,chemistry.chemical_compound ,chemistry ,0103 physical sciences ,Cavity magnetron ,Materials Chemistry ,Composite material ,0210 nano-technology ,Oxidation resistance - Abstract
Zr–Si–N coatings with cyclic gradient concentration were fabricated using reactive direct current magnetron cosputtering. The low-Si-content coatings, Zr60N40 and Zr58Si2N40, exhibited a face-centered cubic (f.c.c.) structure, accompanied with a nanohardness of 21.0–23.6 GPa and a Young's modulus of 248–267 GPa, whereas the medium-Si-content coatings, Zr54Si6N40 and Zr52Si8N40, exhibited a mixture of f.c.c. and near-amorphous structures, accompanied with a nanohardness of 19.7–18.4 GPa and a Young's modulus of 204–207 GPa. When the Si content ranged from 14 to 19 at.%, the structures of Zr–Si–N coatings were X-ray amorphous; those coatings exhibited lower nanohardness levels of 13.7–10.3 GPa and Young's modulus values of 196–148 GPa. The high-Si-content coatings, Zr28Si24N48 and Zr22Si30N48, exhibited an amorphous structure, accompanied with a nanohardness of 13.7–16.2 GPa and a Young's modulus of 196–217 GPa, which were higher than those of the coatings with a Si content of 14–19 at.%. Coatings formed by adding Si into the Zr–N matrix and performing annealing at 600 °C in a 1% O2–99% Ar atmosphere showed notably high oxidation resistance because Si–Zr–O oxide scales formed on the surfaces. The mechanical properties of crystalline Zr–Si–N coatings declined after annealing, whereas near-amorphous Zr–Si–N coatings retained high levels of mechanical properties after annealing.
- Published
- 2017
34. Feasibility Investigation of Amorphous Silicon as Release Layer in Temporary Bonding for 3-D Integration and FOWLP Scheme
- Author
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Kuan-Neng Chen, Yu-Hsiang Huang, Shan-Chun Yang, Chien-Hung Lin, Chuan-An Cheng, and Chia-Lin Lee
- Subjects
Amorphous silicon ,Wire bonding ,Materials science ,Hybrid silicon laser ,Three-dimensional integration ,Analytical chemistry ,02 engineering and technology ,01 natural sciences ,law.invention ,chemistry.chemical_compound ,law ,0103 physical sciences ,Electrical and Electronic Engineering ,Composite material ,010302 applied physics ,laser release ,Laser ablation ,021001 nanoscience & nanotechnology ,Laser ,Electronic, Optical and Magnetic Materials ,chemistry ,Anodic bonding ,lcsh:Electrical engineering. Electronics. Nuclear engineering ,0210 nano-technology ,lcsh:TK1-9971 ,Layer (electronics) ,Polyimide ,temporary bonding ,Biotechnology - Abstract
A reliable temporary bonding scheme with both inorganic amorphous silicon release layer and HD-3007 polyimide based on high 355-nm-wavelength laser absorption coefficient in release layer is proposed and investigated. Effects of laser absorption coefficient and laser ablation path are also studied to develop a high throughput laser ablation process. The bonding scheme can be achieved within the optimized temperature of 210 °C under 1 MPa bonding force. In addition, chemical resistance, mechanical strength with reliability assessment, and thermal stability test for bonded structure are inspected. There is no obvious degradation in electrical characterization after laser ablation, indicating that the temporary bonding scheme has high potential to be used for 3-D integration applications.
- Published
- 2017
35. Characterization of Temporary Bonding and Laser Release Using Polyimide and a 300-nm Photolysis Polymer System for High-Throughput 3-D IC Applications
- Author
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Tsung-Yen Tsai, Chuan-An Cheng, Shan-Chun Yang, Chia-Lin Lee, Kuan-Neng Chen, Yu-Hsiang Huang, and Chien-Hung Lin
- Subjects
010302 applied physics ,chemistry.chemical_classification ,Chemical resistance ,Laser ablation ,Materials science ,business.industry ,02 engineering and technology ,Polymer ,021001 nanoscience & nanotechnology ,Laser ,01 natural sciences ,Industrial and Manufacturing Engineering ,Electronic, Optical and Magnetic Materials ,law.invention ,chemistry ,Anodic bonding ,law ,0103 physical sciences ,Optoelectronics ,Adhesive ,Electrical and Electronic Engineering ,0210 nano-technology ,business ,Layer (electronics) ,Polyimide - Abstract
A new temporary bonding technology with an ultrafast laser-release process of less than 20 s is presented, where a 300-nm-thick photolysis polymer and polyimide are served as the release layer and adhesive layer, respectively. The submicrometer-thick polymer has the feature of high absorption of a 355-nm laser in contrast to polyimide during debonding procedures. In addition, the thin release layers of high chemical resistance and mechanical strength demonstrate their feasibility for handling process. Electrical characteristics of the devices before and after the laser-release process are investigated, showing no degradation. Thus, this technology scheme demonstrates its potential for temporary bonding and release in 3-D integration applications.
- Published
- 2017
36. Molecular Basis of Alarm Pheromone Detection in Aphids
- Author
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Bing Wang, Jinghui Xi, Jian Lu, Gerarda Grossi, Yang Liu, Guirong Wang, Shan-Chun Yan, Patrizia Falabella, and Ruibin Zhang
- Subjects
0106 biological sciences ,0301 basic medicine ,Acyclic Monoterpenes ,Acetates ,Receptors, Odorant ,01 natural sciences ,General Biochemistry, Genetics and Molecular Biology ,03 medical and health sciences ,RNA interference ,Botany ,Animals ,Gene family ,Sensillum ,Genetics ,Aphid ,biology ,Obligate ,Terpenes ,food and beverages ,biology.organism_classification ,High-Throughput Screening Assays ,Acyrthosiphon pisum ,010602 entomology ,030104 developmental biology ,Gene Expression Regulation ,Aphids ,Insect Repellents ,Insect Proteins ,Pheromone ,Heterologous expression ,General Agricultural and Biological Sciences ,Sesquiterpenes - Abstract
Summary The sesquiterpene ( E )-β-farnesene (EBF) is the alarm pheromone for many species of aphids [1]. When released from aphids attacked by parasitoids or predators, it alerts nearby conspecifics to escape by walking away and dropping off the host plant [2, 3]. The reception of alarm pheromone in aphids is accomplished through a highly sensitive chemosensory system. Although olfaction-related gene families including odorant receptors (ORs) and odorant-binding proteins (OBPs) have recently been identified from aphid genomes [4–6], the cellular and molecular mechanisms of EBF reception are still largely unknown. Here we demonstrate that ApisOR5, a member of the large superfamily of odorant receptors, is expressed in large placoid sensillum neurons on the sixth antennal segment and confers response to EBF when co-expressed with Orco, an obligate odorant receptor co-receptor, in parallel heterologous expression systems. In addition, the repellent behavior of Acyrthosiphon pisum to EBF disappears after knocking down ApisOR5 by RNAi as well as two A. pisum odorant-binding proteins known to bind EBF (ApisOBP3 and ApisOBP7). Furthermore, other odorants that can also activate ApisOR5, such as geranyl acetate, significantly repel A. pisum , as does EBF. Taken together, these data allow us to conclude that ApisOR5 is essential to EBF reception in A. pisum . The characterization of the EBF receptor allows high-throughput screening of aphid repellents, providing the necessary information to develop new strategies for aphid control.
- Published
- 2017
37. Research on the Defense Method of Vtable Hijacking
- Author
-
Sun Shiyouhu Changzhen, Wang Zixiang, Xue Jingfeng, and Shan Chun
- Subjects
General Computer Science ,Computer science - Published
- 2016
38. A Vulnerability Detection Model for Java Systems Based on Complex Networks
- Author
-
Zijun Yun, Changzhen Hu, Ling Xiong, Shan Chun, and Wenjie Xiong
- Subjects
050101 languages & linguistics ,Theoretical computer science ,business.industry ,Computer science ,05 social sciences ,Complex system ,02 engineering and technology ,Network theory ,Complex network ,Software ,Software security assurance ,Component (UML) ,0202 electrical engineering, electronic engineering, information engineering ,020201 artificial intelligence & image processing ,0501 psychology and cognitive sciences ,Software system ,Algebraic number ,business - Abstract
With the deepening of research on network theory, scientists have gradually begun to adopt complex networks to look at complex systems in nature. A complex network is a network of a large number of closely related and interacting units. This paper believes that each component of the software can be abstracted into various algebraic components. These algebraic components are assembled into a software system. Its assembly process satisfies the configuration and fit characteristics in the topological space. Using algebraic components as the vertices of complex network graphs, the connection relationship between them is taken as the edge of the complex network graph. Using this new perspective, the software system is regarded as a complex network graph composed of algebraic components and their connection relationships. We have proved that the software system can be abstracted into the form of algebraic component expressions, and can find algebraic components that may have vulnerabilities based on the eigenvalues of complex networks.
- Published
- 2019
39. Magnesium isoglycyrrhizinate ameliorates fructose-induced podocyte apoptosis through downregulation of miR-193a to increase WT1
- Author
-
Ying Pan, Hong-Mei Gu, Xiao-Juan Zhao, Hong-Jiang Xu, Ling-Dong Kong, Dong Ping, Zhang Xiquan, Li Chen, Tu-Shuai Li, Shan-Chun Wang, Zhan-Qiang Shang, and Yan-Zi Yang
- Subjects
0301 basic medicine ,Male ,Cell ,Renal function ,Apoptosis ,Fructose ,urologic and male genital diseases ,Biochemistry ,Podocyte ,Cell Line ,Rats, Sprague-Dawley ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Downregulation and upregulation ,medicine ,Animals ,Humans ,Hepatoprotective Agent ,WT1 Proteins ,Pharmacology ,Proteinuria ,Dose-Response Relationship, Drug ,urogenital system ,business.industry ,Podocytes ,Transfection ,Saponins ,Triterpenes ,Rats ,MicroRNAs ,030104 developmental biology ,medicine.anatomical_structure ,chemistry ,030220 oncology & carcinogenesis ,Cancer research ,medicine.symptom ,business ,Drugs, Chinese Herbal - Abstract
High fructose intake is a risk of glomerular podocyte dysfunction. Podocyte apoptosis has emerged as a major cause of podocyte loss, exacerbating proteinuria. Magnesium isoglycyrrhizinate (MgIG) is usually used as a hepatoprotective agent in clinic. Liver and kidney injury often occurs in human diseases. Recent report shows that MgIG improves kidney function. In this study, we found that MgIG significantly alleviated kidney dysfunction, proteinuria and podocyte injury in fructose-fed rats. It also restored fructose-induced podocyte apoptosis in rat glomeruli and cultured differentiated podocytes. Of note, high-expression of miR-193a, downregulation of Wilms' tumor protein (WT1) and RelA, as well as upregulation of C-Maf inducing protein (C-mip) were observed in these animal and cell models. The data from the transfection of miR-193a mimic, miR-193a inhibitor, WT1 siRNA or LV5-WT1 in cultured differentiated podocytes showed that fructose increased miR-193a to down-regulate WT1, and subsequently activated C-mip to suppress RelA, causing podocyte apoptosis. These disturbances were significantly attenuated by MgIG. Taken together, these results provide the first evidence that MgIG restrains fructose-induced podocyte apoptosis at least partly through inhibiting miR-193a to upregulate WT1, supporting the application of MgIG with a novel mechanism-of-action against podocyte apoptosis associated with fructose-induced kidney dysfunction.
- Published
- 2019
40. Allergy to prebiotic galacto-oligosaccharides: House dust mites-the putative primary sensitizer
- Author
-
Hongmei Wen, Dianne J. Delsing, Youjia Zhong, Si Yuan Leow, Shan Chun Lim, Chiung-Hui Huang, Bee Wah Lee, Li Yuan Gabriella Nadine Lee, Jian Yi Soh, and Wen Chin Chiang
- Subjects
Male ,Allergy ,Primary (chemistry) ,Prebiotic ,medicine.medical_treatment ,Immunology ,Pyroglyphidae ,Cross reactions ,Galactose ,Infant ,Oligosaccharides ,Dust mites ,Biology ,Cross Reactions ,medicine.disease ,Microbiology ,Prebiotics ,Child, Preschool ,medicine ,Hypersensitivity ,Immunology and Allergy ,Animals ,Humans ,Female ,Child - Published
- 2019
41. A XSS Attack Detection Method based on Skip List
- Author
-
Cui Jing, Shan Chun, Wang Hao, Xue Jingfeng, Mhagama Raphael, and Hu Changzhen
- Subjects
High rate ,Skip list ,General Computer Science ,Computer science ,Scripting language ,Cross-site scripting ,Improved algorithm ,False positive paradox ,Computer security ,computer.software_genre ,computer ,Rapid detection ,Constant false alarm rate - Abstract
In recent years, the destruction of cross-site scripting (XSS) attacks is gradually increasing, but the existing XSS defense methods have some problems, such as, complex disposition, low performance, high non-response rates or high rate of false positives. Therefore, it is imminent to establish an efficient XSS defense mechanism. This paper presents a cross-site scripting attacking detection method, which is based on improved algorithm skip list. It can fulfill the rapid detection of cross-site scripting attacks by using some steps, for example, creating a skip list signature, detecting suspicious strings, marking attack vectors and so on. Experiment shows that compared with the traditional defense method of XSS attack, the new defense method can reduce the false alarm rate of detection, and improve the time performance effectively.
- Published
- 2016
42. Online Depth Image-Based Object Tracking with Sparse Representation and Object Detection
- Author
-
Bao-Liang Lu, Shan-Chun Shen, and Wei-Long Zheng
- Subjects
0209 industrial biotechnology ,Computer Networks and Communications ,business.industry ,Computer science ,General Neuroscience ,Pattern recognition ,02 engineering and technology ,Sparse approximation ,Tracking (particle physics) ,Object detection ,Object-class detection ,020901 industrial engineering & automation ,Artificial Intelligence ,Video tracking ,Face (geometry) ,0202 electrical engineering, electronic engineering, information engineering ,Benchmark (computing) ,020201 artificial intelligence & image processing ,Computer vision ,Viola–Jones object detection framework ,Artificial intelligence ,business ,Software - Abstract
Online object tracking under complex environments is an important but challenging problem in computer vision, especially for illumination changing and occlusion conditions. With the emergence of commercial real-time depth cameras like Kinect, depth image-based object tracking, which is insensitive to illumination changing, gains more and more attentions. In this paper, we propose an online depth image-based object tracking method with sparse representation and object detection. In this framework, we combine tracking and detection to leverage precision and efficiency under heavy occlusion conditions. For tracking, objects are represented by sparse representations learned online with update. For detection, we apply two different strategies based on tracking-learning-detection and wider search window approaches. We evaluate our methods on both the subset of the public dataset Princeton Tracking Benchmark and our own driver face video in a simulated driving environment. The quantitative evaluations of precision and running time on these two datasets demonstrate the effectiveness and efficiency of our proposed object tracking algorithms.
- Published
- 2016
43. Theory modeling and finite element analysis of tensile flexure hinge
- Author
-
单春成 Shan Chun-cheng, 王 强 Wang Qiang, 刘 凯 Liu Kai, and 曹 毅 Cao Yi
- Subjects
Materials science ,business.industry ,Ultimate tensile strength ,Hinge ,Structural engineering ,business ,Atomic and Molecular Physics, and Optics ,Finite element method ,Electronic, Optical and Magnetic Materials - Published
- 2016
44. Magnesium isoglycyrrhizinate alleviates fructose-induced liver oxidative stress and inflammatory injury through suppressing NOXs
- Author
-
Xiquan Zhang, Hong-Jiang Xu, Zhi-Hong Liu, Yan-Zi Yang, Shan-Chun Wang, Ling Yang, and Ling-Dong Kong
- Subjects
Male ,0301 basic medicine ,Antioxidant ,medicine.medical_treatment ,Interleukin-1beta ,Anti-Inflammatory Agents ,Inflammation ,Fructose ,Pharmacology ,medicine.disease_cause ,Antioxidants ,Rats, Sprague-Dawley ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,medicine ,Animals ,Humans ,Liver injury ,chemistry.chemical_classification ,Reactive oxygen species ,NADPH Oxidases ,NOX4 ,Hep G2 Cells ,Saponins ,medicine.disease ,Triterpenes ,Disease Models, Animal ,Oxidative Stress ,030104 developmental biology ,Liver ,chemistry ,NADPH Oxidase 4 ,NADPH Oxidase 2 ,NADPH Oxidase 1 ,cardiovascular system ,Chemical and Drug Induced Liver Injury ,Inflammation Mediators ,medicine.symptom ,030217 neurology & neurosurgery ,Nicotinamide adenine dinucleotide phosphate ,Oxidative stress ,Signal Transduction - Abstract
Excessive fructose intake is a risk factor for liver oxidative stress injury. Magnesium isoglycyrrhizinate as a hepatoprotective agent is used to treat liver diseases in clinic. However, its antioxidant effects and the underlying potential mechanisms are still not clearly understood. In this study, magnesium isoglycyrrhizinate was found to alleviate liver oxidative stress and inflammatory injury in fructose-fed rats. Magnesium isoglycyrrhizinate suppressed hepatic reactive oxygen species overproduction (0.97 ± 0.04 a.u. versus 1.34 ± 0.07 a.u.) in fructose-fed rats by down-regulating mRNA and protein levels of nicotinamide adenine dinucleotide phosphate oxidase (NOX) 1, NOX2 and NOX4, resulting in reduction of interleukin-1β (IL-1β) levels (1.13 ± 0.09 a.u. versus 1.97 ± 0.12 a.u.). Similarly, magnesium isoglycyrrhizinate reduced reactive oxygen species overproduction (1.07 ± 0.02 a.u. versus 1.35 ± 0.06 a.u.) and IL-1β levels (1.14 ± 0.09 a.u. versus 1.66 ± 0.07 a.u.) in fructose-exposed HepG2 cells. Furthermore, data from treatment of reactive oxygen species inhibitor N-acetyl-L-cysteine or NOXs inhibitor diphenyleneiodonium in fructose-exposed HepG2 cells showed that fructose enhanced NOX1, NOX2 and NOX4 expression to increase reactive oxygen species generation, causing oxidative stress and inflammation, more importantly, these disturbances were significantly attenuated by magnesium isoglycyrrhizinate. The molecular mechanisms underpinning these effects suggest that magnesium isoglycyrrhizinate may inhibit NOX1, NOX2 and NOX4 expression to reduce reactive oxygen species generation, subsequently prevent liver oxidative stress injury under high fructose condition. Thus, the blockade of NOX1, NOX2 and NOX4 expression by magnesium isoglycyrrhizinate may be the potential therapeutic approach for improving fructose-induced liver injury in clinic.
- Published
- 2020
45. [Food utilization and excretion mechanism of Cd in gypsy moth larvae fed on Cd-enriched Populus albaXP. berolinensis leaves]
- Author
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Dun, Jiang, Gui Qiu, Di, and Shan Chun, Yan
- Subjects
Plant Leaves ,Populus ,Larva ,Animals ,Environmental Pollutants ,Moths ,Cadmium - Abstract
To investigate the eco-physiological responses of phytophagous insects to host plants exposed to heavy metal stress, the gypsy moth (Lymantria dispar) larvae were reared with leaves of Populus albaXP. berolinensis grown in Cd-contaminated soil to analyze their food utilization and mechanisms underlying Cd excretion. Our results showed that after feeding on Cd-stressed poplar leaves, Cd concentrations and contents in the 3rd-6th instar larvae were significantly higher than those in control. The Cd concentrations significantly decreased with the larval age, whereas it was reverse for Cd contents. Cd concentrations in the larval faces and exuvia were significantly higher than those in control. Food digestion/consumption rate and conversion rate of the 3rd-5th instar larvae in the Cd-treatment group were significantly higher and lower than those in the control, respectively. Food utilization rate of the Cd-stressed 3rd-4th instar larvae were not significantly different from that of the control larvae with the same age. In contrast, the Cd-stressed 5th instar larvae showed a significantly lower food utilization rate than the control. These results indicated that gypsy moth larvae could remove some Cd from their bodies through effective excretion (e.g. feces and exuvia), with the mature larvae being more effective than the juveniles. The increases of larval body mass seemed to have a "dilution effect" on its Cd concentration. Under Cd stress, the gypsy moth larvae might maintain a certain level of food utilization rate for growth and development via a modulation of food consumption/conversion rates, but Cd-stress would still reduce the larval food utilization rate when it was beyond a certain threshold.为探明植食性昆虫对受重金属胁迫的寄主植物的生理生态响应机制,本研究用Cd胁迫下银中杨的叶片饲养舞毒蛾幼虫,分析舞毒蛾幼虫对食物的利用情况以及其对Cd的排毒代谢机制.结果表明: 取食Cd胁迫下银中杨的叶片后,舞毒蛾3~6龄幼虫体内的Cd浓度和Cd含量均显著高于对照,但随着幼虫龄期增长,其体内Cd浓度显著降低,而Cd含量有不同程度的提高;舞毒蛾幼虫粪便和虫蜕中的Cd浓度均显著高于对照;舞毒蛾3~5龄幼虫的食物消耗率显著高于对照,而转化率显著低于对照;3~4龄幼虫的食物利用率均与对照差异不显著,但在5龄时显著低于对照.说明在Cd胁迫下,舞毒蛾幼虫能通过有效的排毒代谢途径将体内富集的部分Cd排出体外,且高龄幼虫的排毒代谢能力强于低龄幼虫;舞毒蛾幼虫体质量的增加会对体内的Cd浓度形成一种稀释效应;舞毒蛾幼虫能通过调整食物消耗率和转化率之间的比例,来维持其正常生长发育所需的食物利用率,但超过一定限度后仍会造成食物利用率降低.
- Published
- 2018
46. Design and Implementation of Hotel Room Information Management System Based on Kendo UI Front-End Framework
- Author
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Shan Chun, Mei Shan-Shan, and Xue Jingfeng
- Subjects
Information management ,Management information systems ,Engineering management ,Service (systems architecture) ,Computer science ,business.industry ,Interface (computing) ,The Internet ,User interface ,business ,Task (project management) ,Computer technology - Abstract
In the rapid development of society today, along with the popularization of computer technology and the extensive application of the Internet, all walks of life are applying the computer management system to their own enterprises. As a member of the service industry, the hotel industry is also developing rapidly. In order to integrate the rapid development of computer network and hotel industry, to provide better service to consumers and to improve the management efficiency of hotels, hotel room information management systems have emerged. This article describes a management platform for hotel room's online booking and guest information using kendo UI front-end framework design. Using SSM (Spring, Spring MVC, MyBatis) framework to deal with background programs. The overall mission of system development is to ensure office staff can quickly and easily complete the hotel guest room management task, providing better and faster service for residents. The interface is simple and his operation is easy to maintain.
- Published
- 2018
47. Effects of Cd, Zn, or Pb Stress in Populus alba berolinensis on the Antioxidant, Detoxifying, and Digestive Enzymes of Lymantria dispar
- Author
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Shan-chun Yan and Dun Jiang
- Subjects
0106 biological sciences ,animal structures ,Antioxidant ,medicine.medical_treatment ,010501 environmental sciences ,Moths ,01 natural sciences ,Antioxidants ,Superoxide dismutase ,Stress, Physiological ,Metals, Heavy ,Lymantria dispar ,medicine ,Animals ,Amylase ,Ecology, Evolution, Behavior and Systematics ,0105 earth and related environmental sciences ,Ecology ,biology ,fungi ,Acid phosphatase ,biology.organism_classification ,Horticulture ,Populus ,Seedling ,Catalase ,Insect Science ,Larva ,biology.protein ,Instar ,010606 plant biology & botany - Abstract
For investigating the physiological responses of herbivores to the heavy metal-stressed woody host plants, the activities of antioxidant, detoxifying, and digestive enzymes in the gypsy moth larvae, Lymantria dispar, that were fed with different heavy metal-stressed poplar seedling (Populus alba berolinensis) leaves were studied. The heavy metal treatments included Cd-treated pot soil (1.5 mg/kg), Zn-treated pot soil (500 mg/kg), and Pb-treated pot soil (500 mg/kg), plus an untreated pot soil as the control. Our results showed that compared with the untreated control, superoxide dismutase (SOD) and catalase (CAT) activities in Cd or Zn treatment group were gradually suppressed with the increases of larval ages, but Pb treatment had no significant effects on SOD activities and significantly increased the CAT activities in both fourth and fifth instar larvae; acid phosphatase (ACP) activities were gradually activated and alkaline phosphatase (AKP) activities were gradually inhibited with the increases of larval ages in Cd or Pb treatment group, but Zn treatment significantly increased the activities of ACP and AKP both in fourth and in fifth instar larvae. All three heavy metals tested did not show any significant effects on the amylase and protease activity in the fourth instar larvae but increased their activities in fifth instar larvae. These results suggest that antioxidant, detoxifying, and digestive enzymes constituted the basic defense system for gypsy moth larvae to resist the toxicity originated from the accumulated Cd, Zn, or Pb in poplar leaves, but their defense level varied with metals investigated and larval developmental stages.
- Published
- 2018
48. Heavy Metal Accumulation/Excretion in and Food Utilization of Lymantria dispar Larvae Fed With Zn- or Pb-Stressed Populus alba berolinensis Leaves
- Author
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Shan-chun Yan, Xiao-wen Dong, and Dun Jiang
- Subjects
0106 biological sciences ,animal structures ,media_common.quotation_subject ,Insect ,010501 environmental sciences ,Moths ,01 natural sciences ,Excretion ,Animal science ,Lymantria dispar ,Animals ,Ecology, Evolution, Behavior and Systematics ,Feces ,0105 earth and related environmental sciences ,media_common ,Larva ,Ecology ,biology ,fungi ,Gypsy moth ,biology.organism_classification ,Plant Leaves ,010602 entomology ,Zinc ,Populus ,Lead ,Insect Science ,Instar ,Digestion - Abstract
Heavy metal contaminations have attracted increasing concern worldwide due to their potential damages to the whole ecosystem. This study investigated the heavy metal-accumulation and excretion in, and food utilization of the gypsy moth (Lymantria dispar) larvae that were fed with leaves plucked from poplar seedlings (Populus alba berolinensis) grown in either noncontaminated soil (control), Zn-contaminated soil (500mg/kg), or Pb-contaminated soil (500mg/kg). Our results showed that excretion of heavy metals via insect feces and exuvia is an effective approach to reduce the internal Zn and Pb concentrations, and result in the decrease of Zn and Pb concentrations in the gypsy moth larvae with the increased larval age. In addition, the gypsy moth larvae seemed to have a strong homeostatic adjustment mechanism [between approximate digestibility (AD) and efficiency of conversion of digested food (ECD)] that maintains a stable level of "efficiency of conversion of ingested food (ECI)" regardless of heavy metal (Zn or Pb) contaminations or not, except the fifth instar larvae in which the increase in AD was insufficient to compensate for the decrease of ECD. These results suggest that heavy metal excretions could help the gypsy moth larvae cope with Zn or Pb stress, and the increased digestion of food could meet their energy requirements for both detoxification and growth. However, further increase in Zn or Pb exposure time seemed to inhibit the larval food utilization.
- Published
- 2018
49. High Pulse Pressure is a Risk Factor for Stroke in Elderly Individuals with Coronary Heart Disease and Diabetes Mellitus
- Author
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Yutao Guo, Tao Tao, Yang Shi, Hao Wang, Yutang Wang, Zhi-Bin Li, and Shan-Chun Zhang
- Subjects
medicine.medical_specialty ,Multivariate analysis ,Receiver operating characteristic ,business.industry ,Odds ratio ,medicine.disease ,Pulse pressure ,Blood pressure ,Internal medicine ,Diabetes mellitus ,medicine ,Cardiology ,cardiovascular diseases ,Risk factor ,business ,Stroke - Abstract
Background : The association between pulse pressure and the risk of stroke in elderly patients with multiple comorbidities is not well understood. The present study aimed to investigate the association between pulse pressure and the risk of stroke in elderly patients. Measurements : We retrospectively assessed stroke/ transient ischemic attack (TIA) risk factors in 623 patients (33% female, median age, 74 years) with coronary heart disease (CHD) and diabetes mellitus (DM) at Chinese PLA General Hospital. The effects of systolic blood pressure (SBP), diastolic blood pressure (DBP), and pulse pressure on the risk of stroke/TIA were assessed using a binary logistic regression analysis. The ability of changes in blood pressure to predict the risk of stroke/TIA was assessed using a receiver operating characteristics curve. Results : 228 (36.59%) patients had a stroke/TIA. DBP was significantly lower in the patients with stroke/TIA than in those without (75.83 ± 11.14 vs. 78.91 ± 11.85, P = 0.001). Pulse pressure was markedly higher in the stroke/TIA compared with the non-stroke/TIA group (61.34 ± 14.59 vs. 56.01 ± 14.65, P < 0.001). SBP was not significantly different between the groups. The multivariate analysis revealed pulse pressure (odds ratio, (OR), 1.02, 95% confidential interval (CI), 1.01–1.04, P < 0.001) and DBP ≤70 mmHg (OR, 95% CI, 1.44, 1.01–2.06, P =0.044) were independently associated with the risk of stroke/TIA. The c -statistics (95% CI) for pulse pressure and DBP ≤70 mmHg for predicting stroke/TIA were 0.62 (0.57–0.66; P
- Published
- 2015
50. Elevated Serum Levels of NSE and S-100β Correlate with Increased Risk of Acute Cerebral Infarction in Asian Populations
- Author
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Ke Li, Zhen-Fu Wang, Shan-Chun Zhang, and Jian-Jun Jia
- Subjects
Male ,medicine.medical_specialty ,Asia ,education ,Enolase ,Brain Abscess ,Subgroup analysis ,S100 Calcium Binding Protein beta Subunit ,Gastroenterology ,Elevated serum ,Internal medicine ,Diagnosis ,Acute cerebral infarction ,Humans ,Medicine ,Infarction, Anterior Cerebral Artery ,Technetium Tc 99m Aggregated Albumin ,Aged ,business.industry ,Case-control study ,Cerebral Infarction ,General Medicine ,Middle Aged ,Increased risk ,Case-Control Studies ,Phosphopyruvate Hydratase ,Meta-analysis ,Acute Disease ,Immunology ,Inclusion and exclusion criteria ,Female ,business ,Biomarkers ,Meta-Analysis - Abstract
Background We investigated the clinical value of serum levels of neuron-specific enolase (NSE) and human soluble protein-100β (S-100β) in acute cerebral infarction (ACI) patients. Material and methods A literature search of electronic databases identified relevant case-control studies that examined the correlations between NSE and S-100β serum levels, and ACI. The retrieved studies were screened based on our strict inclusion and exclusion criteria, and high-quality studies were subsequently selected for meta-analysis. STATA software (Version 12.0, Stata Corporation, College Station, TX, USA) was utilized for statistical analysis. Results A total of 13 case-control studies, containing 911 ACI patients and 686 healthy controls, were enrolled in this meta-analysis. The results of the meta-analysis showed that serum levels of NSE and S-100β in ACI patients were significantly higher than the control group. Subgroup analysis based on ethnicity revealed that the serum levels of NSE and S-100β in ACI patients were significantly higher than the control group in Asian population. In Caucasian population, the serum levels of NSE in case group was significantly higher than the control group, but no significant differences in serum levels of S-100β were observed between ACI patients and the control group. Conclusions Based on our results, we conclude that serum levels of NSE and S-100β strongly correlate with ACI in Asian population, and may be important clinical markers for diagnosis and treatment of ACI.
- Published
- 2015
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