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5 results on '"Stefanescu, Horia"'

3. Anticoagulation improves overall survival through portal vein recanalization in patients with cirrhosis and portal vein thrombosis: Individual patient data meta-analysis (IMPORTAL study)

Author

Guerrero, Antonio, Del Campo, Laura, Piscaglia, Fabio, Reiberger, Thomas, Han, Guohong, Violi, Francesco, Costa Noronha Ferreira, Carlos Alberto, Luis, Tellez, Garcia Pagan, Juan Carlos, Artaza Varasa, Tomas, Valla, Dominique, VINCENZO LA MURA, Luca, Angelo, Stanciu, Carol, Senzolo, Marco, Amitrano, Lucio, Durand, Francois, Stefanescu, Horia, Scheiner, Bernhard, Basili, Stefania, Magaz, Marta, Castro Nery, Filipe Gaio, Chevret, Sylvie, Primignani, Massimo, Girleanu, Irina, Zamora, Javier, and Albillos, Agustin

4. Comparison of screening strategies with two new tests to score and diagnose varices needing treatment

Author

Paul Calès, Federico Ravaioli, Arthur Berger, Oana Farcau, Davide Festi, Horia Stefanescu, Carole Vitellius, Pierre Nahon, Christophe Bureau, Nathalie Ganne-Carriè, Annalisa Berzigotti, Victor de Ledinghen, Salvatore Petta, Calès, Paul, Ravaioli, Federico, Berger, Arthur, Farcau, Oana, Festi, Davide, Stefanescu, Horia, Vitellius, Carole, Nahon, Pierre, Bureau, Christophe, Ganne-Carriè, Nathalie, Berzigotti, Annalisa, de Ledinghen, Victor, and Petta, Salvatore

Subjects
Liver Cirrhosis, Hepatology, Non-invasive test, Platelet Count, Gastroenterology, Esophageal and Gastric Varices, Varicose Veins, Elastometry, Non-alcoholic Fatty Liver Disease, Oesophageal varice, Screening, Elasticity Imaging Techniques, Humans, Portal hypertension, Retrospective Studies
Abstract

Background and aims: We aimed to improve non-invasive screening of varices needing treatment (VNT) and compare different screening strategies. Methods: 2,290 patients with chronic liver disease were included in a retrospective study. Etiologies were: virus: 50.0%, NAFLD: 29.5%, alcohol: 20.5%, VNT: 14.9%. Test descriptors were performance (spared endoscopy) and safety (missed VNT). VNT tests were evaluated according to their safety levels either for individual screening (95% negative predictive value (NPV)), population screening (95% sensitivity) or undifferentiated screening (100% sensitivity/NPV) without missed VNT. The tests provided three categories: missed VNT

Published
2022

5. Point quantification elastography in the evaluation of liver elasticity in healthy volunteers: a reliability study based on operator expertise

Author

Chiara De Molo, Elena Nardi, Fabio Conti, Pietro Andreone, Horia Stefanescu, Carla Serra, Antonio Maria Morselli-Labate, Cristina Felicani, Veronica Gabusi, Elena Mazzotta, Felicani, Cristina, De Molo, Chiara, Stefanescu, Horia, Conti, Fabio, Mazzotta, Elena, Gabusi, Veronica, Nardi, Elena, Morselli-Labate, Antonio Maria, Andreone, Pietro, and Serra, Carla

Subjects
Adult, Male, Intraclass correlation, Body Mass Index, 030218 nuclear medicine & medical imaging, 03 medical and health sciences, 0302 clinical medicine, Operator (computer programming), Liver stiffness, Healthy volunteers, Internal Medicine, Elastography, Elastosonography, Point shear wave, Reproducibility, Radiology, Nuclear Medicine and Imaging, Humans, Medicine, Radiology, Nuclear Medicine and imaging, Prospective Studies, Aged, Observer Variation, medicine.diagnostic_test, business.industry, Liver stiffne, Reproducibility of Results, General Medicine, Middle Aged, Overweight, Liver, Liver biopsy, Elasticity Imaging Techniques, Female, Original Article, 030211 gastroenterology & hepatology, business, Transient elastography, Nuclear medicine
Abstract

PURPOSE: The assessment of liver fibrosis is essential in the management of patients with chronic liver diseases. Liver biopsy is considered the gold standard procedure for this purpose, though the recent development of new elastosonographic techniques to measure liver stiffness (LS) noninvasively is promising. Point quantification elastography (PQE) showed good results but less is known about the level of skill needed to obtain reliable results. The aim of the study was to evaluate the reproducibility of PQE in assessing LS in healthy subjects comparing three operators with different expertise. METHODS: Between December 2012 and April 2013, 50 consecutive healthy volunteers (18 males, 32 females), median age 30 years (range 25–66) and BMI 22.4 (range 16.7–33.6) were submitted to PQE (iU22 Philips, Bothell, WA, USA) by three operators: two US and elastography providers (one expert and one with intermediate skill) and a skilled transient elastography (Fibroscan) operator with no expertise in US. Intra- and inter-observer agreements were assessed by intraclass correlation coefficient (ICC). RESULTS: PQE measurement was obtained in all subjects by all evaluators. No significant differences of mean liver stiffness were found among operators (P = 0.980). Intra-observer agreement was excellent 0.918 (0.941 for expert, 0.917 for intermediate and 0.888 for novice). The ICC of the inter-observer agreement among the three ratters was excellent (0.882) and was higher in normal than overweight patients (0.923 vs. 0.603; P = 0.011). CONCLUSION: PQE is a reliable and reproducible non-invasive method for the assessment of LE, and can be performed also by a non-experienced operator.

Published
2018

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