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1. γ-Linolenic acid in maternal milk drives cardiac metabolic maturation

Author

Ana Paredes, Raquel Justo-Méndez, Daniel Jiménez-Blasco, Vanessa Núñez, Irene Calero, María Villalba-Orero, Andrea Alegre-Martí, Thierry Fischer, Ana Gradillas, Viviane Aparecida Rodrigues Sant’Anna, Felipe Were, Zhiqiang Huang, Pablo Hernansanz-Agustín, Carmen Contreras, Fernando Martínez, Emilio Camafeita, Jesús Vázquez, Jesús Ruiz-Cabello, Estela Area-Gómez, Fátima Sánchez-Cabo, Eckardt Treuter, Juan Pedro Bolaños, Eva Estébanez-Perpiñá, Francisco Javier Rupérez, Coral Barbas, José Antonio Enríquez, Mercedes Ricote, Agencia Estatal de Investigación (España), Instituto de Salud Carlos III, Junta de Castilla y León (España), Ministerio de Ciencia e Innovación (España), Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF), Swedish Research Council, Swedish Cancer Society (Cancerfonden), Novo Nordisk Foundation, Fondation Leducq, Fundación La Marató TV3, Ministerio de Economía y Competitividad (España), Fundación ProCNIC, and Ministerio de Ciencia e Innovación. Centro de Excelencia Severo Ochoa (España)

Subjects
Multidisciplinary
Abstract

Birth presents a metabolic challenge to cardiomyocytes as they reshape fuel preference from glucose to fatty acids for postnatal energy production1,2. This adaptation is triggered in part by post-partum environmental changes3, but the molecules orchestrating cardiomyocyte maturation remain unknown. Here we show that this transition is coordinated by maternally supplied γ-linolenic acid (GLA), an 18:3 omega-6 fatty acid enriched in the maternal milk. GLA binds and activates retinoid X receptors4 (RXRs), ligand-regulated transcription factors that are expressed in cardiomyocytes from embryonic stages. Multifaceted genome-wide analysis revealed that the lack of RXR in embryonic cardiomyocytes caused an aberrant chromatin landscape that prevented the induction of an RXR-dependent gene expression signature controlling mitochondrial fatty acid homeostasis. The ensuing defective metabolic transition featured blunted mitochondrial lipid-derived energy production and enhanced glucose consumption, leading to perinatal cardiac dysfunction and death. Finally, GLA supplementation induced RXR-dependent expression of the mitochondrial fatty acid homeostasis signature in cardiomyocytes, both in vitro and in vivo. Thus, our study identifies the GLA-RXR axis as a key transcriptional regulatory mechanism underlying the maternal control of perinatal cardiac metabolism. Sí

Published
2023
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2. Modulations on inflammatory and humoral immune responses to oxidized LDL and apolipoprotein B-100 epitope before and after coronary angioplasty

Author

Henrique Andrade Rodrigues da Fonseca, Antonio Carlos de Camargo Carvalho, Adriano Henrique Pereira Barbosa, Magnus Gidlund, Viviane Aparecida Rodrigues Sant'Anna, José Marconi Almeida de Sousa, and Rodrigo Souza

Subjects
Apolipoprotein B, biology, business.industry, medicine.medical_treatment, Epitope, Immunity, Humoral, Lipoproteins, LDL, Epitopes, Immune system, LIPOPROTEÍNAS, Angioplasty, RC666-701, Immunology, Apolipoprotein B-100, biology.protein, Medicine, Diseases of the circulatory (Cardiovascular) system, Humans, Angioplasty, Balloon, Coronary, Cardiology and Cardiovascular Medicine, business, Oxidation-Reduction, Oxidized ldl
Published
2020

3. Implementation of a Brazilian Cardioprotective Nutritional (BALANCE) Program for improvement on quality of diet and secondary prevention of cardiovascular events: A randomized, multicenter trial

Author

Sende O. de Jesus, Fernanda C. Amparo, Marta M. David, Sara Bobadra, Lilian P.S. Costa, Keyla L.A.L. Deucher, Juliana D Oliveira, Izabele Vian, Janaina Maiana Abreu Barbosa, Karina C.S. Missias, Alexandre Biasi Cavalcanti, Luisa P. Silva, Lannay Ferreira da Silva, Andrea P. Galante, Adriana Barros Luna, Jâniffer R. Beiersdorf, Ângela Cristine Bersch-Ferreira, Diana S. Russo, Marilia C.S. Lucas, Maria Bárbara Galdino Silva, Monique T. de Jesus, Rosângela Maria Lopes de Sousa, Délcio G.S. Junior, Raquel Milani El Kik, Sandramara Sasso, Celme B.P. de Araújo, Nathalia P. Bachettini, Maria A. Moraes, Neuma M.F.S. Leda, Cristine E. Nunes, Bruna G. Machado, Rafael M. Soares, Salvador S. Ramos, Bianca A.S. de Oliveira, Rosa Bosquetti, Cristiano P. dos Santos, Franciane Silvana Formentini, Adriana O.L. Veríssimo, Rosielle Batista Ferreira, Clenise F. Dantas, Valdiana B. Vasconcelos, Maria Renata Aragão dos Santos, Ana Paula O. de Queirós, Edite M.V.M. C. de Araújo, Luciana Pereira Pinto Dias, Francisca Eugenia Zaina Nagano, Sandra Mary Lima Vasconcelos, Elaine de Fatima Adorne, Gabriela S. Shirmann, Celma M. Martins, Aldair S. Guterres, Ana Paula Silva Caldas, Marina Berbigier, Alessandra C. Caiado, Fernanda L. Chiesa, Laís N.P. Navarro, Vera Elizabeth Closs, Raira Pagano, Cristina H. Matos, Juliane A. Rodrigues, Luciana B. Gonçalves, Raphaela Costa Ferreira, Rosana P. Costa, Isa G. Rodrigues, Emílio Hideyuki Moriguchi, Rebecca O. Maquiné, Ana P.P.F. Carvalho, Daniela O. Peçanha, Alessandra Doumid Borges Pretto, Michelle R. Santos, Mirena Boklis, Celia R. Bittencourt, Eduardo P. Trescastro, Mariana E.P. Lima, Bruna L.P. Ribas, Adriana F. Teixeira, Marina T. Asoo, Maria I.S. Taboada, Otavio Berwanger, Karen B. Ruschel, Suzi H.A. de Araujo, Nilma F. Silva, Rodrigo Necchi, Camile S. Teixeira, Vanessa C.F.O. Fagundes, Glauber B. da Silva, Carine S.A. Ribeiro, Francisco A. Costa, Sônia L. Pinto, Helen Hermana Miranda Hermsdorff, Suzana A. da Silva, Bárbara Rafaela Santos da Rocha, Rosileide S. Torres, Cíntia L. Ambrozio, Renata Torres Abib Bertacco, Rosângela C.A. Cantanhede, Annie S.B. Moreira, Camila Dourado, Aline Marcadenti, Milena P. Rodrigues, Renata A. da Silva, Daniele M.O. Carlos, Cláudia Porto Sabino Pinho, Rita C.L. Duarte, Lilian Vivian, Eliane S. Dutra, Neyla E. Silva, Luciano M. Backes, Lívia M.A.J. Silva, Letícia S. Sabino, Júlia D. Lopes, Alexsandro Ferreira dos Santos, Lúcia H.A. Gratão, Paulo Victor Gomes Modanese, Cristina T. Telles, Juliana L. Pereira, Luciana V.S. Alves, Tainah S. Souza, Lúcia Rota Borges, Maria Cristina de Oliveira Izar, Priscila Moreira, Simone Raimondi de Souza, Priscila A. Rodrigues, Jorge L. Boemo, Deborah Marotto, Eduardo Gehling Bertoldi, Priccila Zuchinali, Jéssica Schiavini, Susi B. e Lima, Claiza Barretta, Jacqueline T. da Silva, Alexandre Gastaud, Daniela Rampazzo, Vera M.S. Bortonili, Laís B. da Costa, Luciana C. Holzbach, Sabrina A. Vieira, Maria E.M. Ramos, Waldemar de Carli, Magali C.C. Kumbier, Tamirys D. Sangali, Renato Hideo Nakagawa Santos, Elisa M. Santos, Roberta Mânica Cardoso, Simone M. Fischer, Marina K. Ito, Andreza M. Penafort, Naoel H. Feres, Bruno R.B. de Ataíde, Mihaela Onofrei, José Albuquerque de Figueiredo Neto, Camila R. Honório, Enilda de Sousa Lara, Catharina C.J. Paiva, Marina Shumacher, Gabriela C. Souza, Rafael L. Rech, Viviane Aparecida Rodrigues Sant'Anna, Antônio Carlos Sobral Sousa, Laura M. da Costa, André Eduardo da Silva Júnior, Luíza M. Garlini, Cintia G.N.C. Cordeiro, Rose M. Uehara, Karina G. dos Santos, Josilene Maria Ferreira Pinheiro, Natalia de Morais Cunha, Camila Ragne Torreglosa, Luis G.S. Mota, Valéria A. Machado, Geysa Maria Nogueira Farias, Auriene L. Medeiros, Amanda G.L. Coura, Kellen C. Silva, Karine Maria Moreira Almeida, Lívia A. Pellegrini, Luana R.M. Lima, Guilherme C.M. Bragança, Joise M. Teixeira, Aline Longo, Vanessa Bertoni, Cristiane Kovacs, Fernanda Vighi Dobke, Paula Souza, Alessandra da Silva, Elza C.B. Barbosa, Clarice M. Specht, Carlos D. Magnoni, Alechandra S. Napparo, Isadora Bianco Cardoso, Mônica L.P. de los Santos, Camila V.S. Souza, Jaqueline S.O. Vieira, Viviane O.G. Nascimento, Luisa F. Reis, Andrea F.R. Cardoso, Jadson M. Morais, Helen M.S. Carvalho, Ana L. Barreto, Lais S. de Paula, Aline S. Monteiro, Josiele Kesties, Ana C.L. Andrade, Juliana T. Kato, Bernardete Weber, Tatiana M.X. de Meneses, Priscila M. Pinho, Thiago T. de Freitas, Joyce Salamoni, Moacyr M. Palmeira, Malaine M.A. Machado, Bianca M. Fracasso, Viviane Sahade, Givaldo A. Araújo, Fernando G. Zampieri, Matheus Brum Felício, Soraia Poloni, Neide M. Bruscato, Caroline Frehner, Josefina Bressan, Andreza Santos Almeida, Socorro N.A.A. Barbosa, Helyde Albuquerque Marinho, Patrícia R.T. Martins, Maiara Cantarelli, and Monica Damiani

Subjects
Male, Nutrition Education, Body Mass, National Health Programs, 030204 cardiovascular system & hematology, Vegetable, Procedures, Prescription, law.invention, 0302 clinical medicine, Cerebrovascular Accident, Randomized controlled trial, law, Risk Factors, Cardiovascular Disease, Cause of Death, Clinical endpoint, Whole Grain, Secondary Prevention, 030212 general & internal medicine, Myocardial infarction, All Cause Mortality, Amputation, Program Development, Stroke, Sex Difference, Alcohol Consumption, Incidence (epidemiology), Incidence, Unstable Angina Pectoris, Middle Aged, Clinical Trial, Hospitalization, Multicenter Study, Survival Rate, Practice Guideline, Cardiovascular Diseases, Randomized Controlled Trial, Priority Journal, Female, Public Health, Cardiology and Cardiovascular Medicine, Brazil, Human, Adult, medicine.medical_specialty, Major Clinical Study, Nutritional Status, Follow Up, 03 medical and health sciences, Age, Cause Of Death, Multicenter trial, Internal medicine, medicine, Humans, Controlled Study, Nutritional Assessment, Study Design, Unstable angina, business.industry, Brasil, Risk Factor, medicine.disease, Heart Infarction, Heart Arrest, Diet, Blood pressure, Nutrition Assessment, Fruit, Family Income, business, Cardiovascular Risk, Diet Therapy, Nutritional Counseling, Total Quality Management
Abstract

Background: Appropriate dietary recommendations represent a key part of secondary prevention in cardiovascular disease (CVD). We evaluated the effectiveness of the implementation of a nutritional program on quality of diet, cardiovascular events, and death in patients with established CVD. Methods: In this open-label, multicenter trial conducted in 35 sites in Brazil, we randomly assigned (1:1) patients aged 45 years or older to receive either the BALANCE Program (experimental group) or conventional nutrition advice (control group). The BALANCE Program included a unique nutritional education strategy to implement recommendations from guidelines, adapted to the use of affordable and regional foods. Adherence to diet was evaluated by the modified Alternative Healthy Eating Index. The primary end point was a composite of all-cause mortality, cardiovascular death, cardiac arrest, myocardial infarction, stroke, myocardial revascularization, amputation, or hospitalization for unstable angina. Secondary end points included biochemical and anthropometric data, and blood pressure levels. Results: From March 5, 2013, to Abril 7, 2015, a total of 2534 eligible patients were randomly assigned to either the BALANCE Program group (n = 1,266) or the control group (n = 1,268) and were followed up for a median of 3.5 years. In total, 235 (9.3%) participants had been lost to follow-up. After 3 years of follow-up, mean modified Alternative Healthy Eating Index (scale 0-70) was only slightly higher in the BALANCE group versus the control group (26.2 ± 8.4 vs 24.7 ± 8.6, P

Published
2019

4. TCT-648 Percutaneous coronary intervention modulates the natural humoral immune response in relation to the degree of coronary artery disease

Author

Henrique Andrade Rodrigues da Fonseca, Maria Cristina de Oliveira Izar, Guilherme Cintra, Rodrigo Souza, José Marconi Almeida de Sousa, Marco Tulio Souza, Viviane Aparecida Rodrigues Sant'Anna, Francisco Antonio Helfenstein Fonseca, Claudia Maria Rodrigues Alves, Adriano Henrique Pereira Barbosa, Magnus Gidlund, and Antonio Carlos Carvalho

Subjects
medicine.medical_specialty, business.industry, medicine.medical_treatment, Percutaneous coronary intervention, medicine.disease, Coronary artery disease, Immune system, Antigen, Internal medicine, Conventional PCI, medicine, Cardiology, Cardiology and Cardiovascular Medicine, business, Oxidized ldl
Abstract

Auto antigens such as oxidized LDL have been implicated as atherogenic agents found in atheromatous lesions. It has not been observed whether percutaneous coronary intervention (PCI) can modulate the natural or adaptive humoral immune response to auto antigens according to the degree of

Published
2017
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