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The objective of this study is to investigate a high-throughput cipher-block chaining (CBC) mode crypto circuit, which can be embedded in commercial home gateways or switches/routers. Concurrently, the area efficiency of block ciphers can be improved as well. However, the CBC mode encounters the problem of data dependency. To solve this issue, a data scheduling mechanism of network packets is proposed to eliminate the data dependency of input data for CBC mode pipelined crypto engines. The proposed CBC mode architecture can be applied to advanced encryption standards (AES), triple data encryption standards (3DES), and other block ciphers. In addition, to increase the throughput, deeply pipelined AES-CBC and 3DES-CBC circuits with balanced paths are proposed. With the proposed scheduling and pipelined circuits, the authors can effectively encrypt the packet data of multiple network channels at the same time. Using the proposed architecture, throughputs of 137.8 and 44.75 Gbps using a copy of pipelined AES-CBC and 3DES-CBC circuits can be achieved in TSMC 45 nm and TSMC 130 nm processes, respectively.

Background: In the face of the COVID-19 pandemic, surgical personnel and patients experience many diagnosis and treatment-related challenges. COVID-19 is highly virulent, and thus, immediate, safe, and effective solutions to the patients’ management are required. Research collaboration and knowledge dissemination are necessary to optimize medical and surgical approaches to the individual patients’ needs. Gastric manifestations of SARS-CoV-2 infection are not uncommon and may even precede respiratory symptoms. Common gastrointestinal symptoms include loss of appetite, diarrhea, nausea, vomiting and abdominal pain. Case Presentation: A 50-year-old male patient complained of "blood in the stool and tenesmus for half a year" and was admitted to the hospital on March 2, 2023. Half a year ago, the patient had blood in the stool without obvious incentives, the bleeding was bright red, the habit of defecation changed, the stool became thinner, and the frequency of defecation increased, 3-5 times a day, and the amount was not much. At that time, he went to a regular medical institution for any treatment measures.

Background: Treatment given as a first step to shrink a tumor before the main treatment, which is usually surgery, is given. Examples of neoadjuvant therapy include chemotherapy, radiation therapy, and hormone therapy. It is a type of induction therapy. The most common pattern of esophageal cancer metastases (ECM) is to the lymph nodes, lung, liver, bones, adrenal glands, and brain. Case Presentation: A male patient, 47 years old, was admitted to the hospital on July 31, 2020, mainly due to "progressive dysphagia. Two months ago, the patient had difficulty eating without obvious incentives, especially when eating hard food such as rice. The liquid diet was acceptable, accompanied by retrosternal pain and discomfort, heartburn, and obvious weight loss. The symptoms gradually aggravated without obvious relief. Conclusion: In summary, there are few international investigations and an absence of relevant information and literature on the environment in which tumor cells survive after radiotherapy. Clinicians can't ignore the issue of whether radiotherapy will alter the tumor cells' natural environment, leading to tumor cell escape and an increase in brain metastases.

Objective: Tumor surgeons now pay special attention to the alteration in breast form following breast-conserving surgery. Safety of breast-conserving margins and postoperative breast appearance are typically challenging in conventional breast-conserving surgery due to the effect of variables such as big breast tumors or unusual placements. It's important to remember that postoperative breast deformity is a real possibility. Breast-conserving tumor plastic surgery combines tumor excision with plastic surgery, allowing for a more thorough removal of the tumor. It provides a more humane treatment option for the majority of patients by ensuring the safety of surgical margins, considering the aesthetic effects, increasing the breast-conserving opportunities for patients with tumors in special parts, and expanding the indications for breast-conserving surgery. It also greatly improves the postoperative quality of life and mental state. In this article, we deeply examine the current state of knowledge concerning the effectiveness, safety, and appropriate patient population for breast-conserving surgery in the context of tumor plastic surgery.

Ternary transition metal sulfides have attracted much attention due to their superior electrochemical properties. Nevertheless, it is difficult to commercialize sulfides due to their intrinsic properties such as dull reaction kinetics and an insufficient number of active sites. Herein, a self-supporting porous NiCoMnS sulfide (NiCoMnS/NF) arrayed on nickel foam (NF) with 3D honeycomb-like structure was designed and prepared via a hydrothermal and post-sulfidation process. It was found that the 3D hierarchically network architecture, constructed by nanosheets with abundant cavities, endowed NiCoMnS/NF with a high specific area and rich ion/electron-transport channels, which facilitated ion/electron transfer and Faradaic reaction kinetic. The optimal NiCoMnS/NF exhibited a markedly improved electrochemical performance due to the merits of complementary multi-composition and unique 3D network structure with multi-level "superhighways". Furthermore, the NiCoMnS//AC device fabricated with NiCoMnS/NF cathode and activated carbon (AC) anode delivered an excellent specific charge and exceptional energy density. This work offers a reference for designing the structure of electrode materials.

PURPOSE Pembrolizumab or nivolumab plus chemotherapy was approved as a first-line treatment for high programmed cell death ligand 1 (PD-L1)–expressing esophageal squamous cell carcinoma (ESCC) by the European Medicines Agency, whereas the US Food and Drug Administration approved this regimen regardless of PD-L1 expression. The superiority of programmed death-1 (PD-1) antibody plus chemotherapy over chemotherapy alone in patients with low PD-L1–expressing ESCC remains debatable. METHODS Post hoc analysis of the Chinese JUPITER-06 study focusing on efficacy stratified by PD-L1 tumor proportion score (TPS; using JS311 antibody) was conducted. Electronic databases were searched to identify eligible randomized controlled trials for meta-analysis. Study-level pooled analyses of hazard ratios (HRs) for overall survival and progression-free survival and odds ratios for objective response rate according to PD-L1 expression were performed. RESULTS The post hoc analysis of JUPITER-06 showed more prominent clinical benefit with PD-1 antibody plus chemotherapy than with chemotherapy alone in both the high and low PD-L1–expressing subgroups. Five randomized controlled trials were included in the meta-analysis, and two PD-L1 expression scoring criteria, TPS (≥ 1%/< 1%) and combined positive score (CPS, ≥ 10/< 10), were analyzed. Significant overall survival benefit by adding PD-1 antibody to chemotherapy was observed in both the TPS < 1% (HR, 0.74; 95% CI, 0.56 to 0.97) and CPS < 10 (HR, 0.77; 95% CI, 0.66 to 0.89) subgroups. Similarly, significantly prolonged progression-free survival was observed in both the TPS < 1% (HR, 0.66; 95% CI, 0.50 to 0.86) and CPS < 10 (HR, 0.63; 95% CI, 0.47 to 0.84) subgroups. In addition, the objective response rate of the TPS < 1% subgroup was significantly improved (odds ratio, 1.71; 95% CI, 1.27 to 2.29). In all high PD-L1–expressing subgroups, the pooled benefit of PD-1 antibody plus chemotherapy was significantly better than that of chemotherapy. CONCLUSION This study provided novel evidence supporting the superiority of PD-1 antibody plus chemotherapy to chemotherapy alone in patients with advanced ESCC with low PD-L1 expression. Further studies of predictive biomarkers are warranted.

The S = ½ spin chain salts [FxCl1−x-BzPy][Ni(mnt)2] (0–1) show a phase transition, and an anomalous change of TC and J/kB with x.

A new donor–acceptor type circularly polarized luminescence material has been developed, and a dihedral angle engineering strategy has been demonstrated for the first time to significantly amplify the luminescence dissymmetry factors.

A 3D Mn-based MOF [Mn(BGPD)(H2O)2] (Mn-BGPD) was synthesized. The asymmetrical supercapacitor of Mn-BGPD exhibits an excellent energy density and better cycling stability.

Solid acidic ionic liquid (Macro-UiO-67-ILs) bearing a macroporous structure for high-performance catalytic esterification.

The nonselective membrane disruption of antimicrobial peptides (AMPs) helps in combating the antibacterial resistance. But their overall positive charges lead to undesirable hemolysis and toxicity toward normal living cells, as well as the rapid clearance from blood circulation. In consequence, developing smart AMPs to optimize the antimicrobial outcomes is highly urgent. Relying on the local acidity of microbial infection sites, in this work, we designed an acidity-triggered charge reversal nanotherapeutics with adaptable geometrical morphology for bacterial targeting and optimized therapy. C

Here, the ground-state structures, electronic structures, polarizability, and spectral properties of metal-free phthalocyanine (H

Objective: With the development of Internet finance, the scale of peer-to-peer (P2P) online lending platforms have rapidly expanded. Additionally, the phenomenon of losses among online lending platforms and the problem of default by borrowers have emerged, greatly restricting the healthy development of online lending platforms. Therefore, it is necessary to dynamically set the credit rating of the borrowers according to the performance of the borrowers, and establish a default risk evaluation model for the borrowers of the online lending platform to promote the healthy development of the online lending platform. Method: This paper uses web crawler technology to obtain borrower information as the sample data, selects 17 core variables as explanatory variables, and utilizes project status as the target variable. First, according to the performance of the borrower, we use K-means to cluster, obtain a dynamic credit rating by calculation and reset the rating to obtain new borrower information. Second, we determine the optimal parameters of the support vector machine algorithm through cross-validation and establish the best evaluation model for online loan borrowers' default risk. Finally, we conduct experimental verification. Results: The classification accuracy of the proposed algorithm is better than that of decision trees and random forest, and the classification effect is the strongest. Conclusion: The experimental results show that the model has good stability and generalizability, and the research results provide dynamic decision support for early warnings of online lending platform risk and risk prevention and control; they can thus help promote the healthy development of online lending platforms.

EN1 is well known as a transcription factor in other tumours, but its role in NPC is unclear. In this study, we first used bioinformatics to analyse GEO data to obtain the differentially expressed gene EN1, and subsequently verified that EN1 was highly expressed in nasopharyngeal carcinoma cells by tissue microarrays as well as cell lines. Further, we down-regulated the expression of EN1 in cells for RNA sequencing. The analysis of sequencing results using KEGG and GO revealed significant changes in cell proliferation and cycle function after downregulation of EN1. Meanwhile, we found that cells underwent senescence after inhibition of EN1 under electron microscopy and the SA-β-gal assays. Based on the sequencing results, we verified that EN1 can promote the proliferation and cycle of NPC cells in cell function experiments and animal experiments. To investigate how EN1 affects cell senescence, we found that EN1 transcriptional regulation of COL22A1 regulated cell proliferation and cycle via CDK4/6-cyclin D1-Rb signalling pathway by dual luciferase reporter, Immunoblotting and rescue experiment. Accordingly, we uncovered that EN1 could serve as a target for the regulation of senescence in NPC.

Objective: This study aimed to evaluate the efficacy and safety of high-frequency oscillation ventilation combined with volume guarantee (HFOV-VG) in preterm infants with acute hypoxemic respiratory failure (AHRF) after patent ductus arteriosus ligation. Methods: We retrospectively analyzed the clinical data of 41 preterm infants, who were ventilated for AHRF after patent ductus arteriosus ligation between January 2020 and January 2022. HFOV alone was used in 20 of the 41 infants, whereas HFOV-VG was used in the other 21 infants. Results: There was no statistically significant difference in the demographic information and baseline characteristics of preterm infants included in the study. The average frequency tidal volume (VThf) of the HFOV-VG group was lower than that of the HFOV group (2.6 ± 0.6 mL versus 1.9 ± 0.3 mL, P < .001). In addition, the incidence of hypocapnia and hypercapnia in infants supported with HFOV-VG was significantly lower (15 versus 8, P < .001; 12 versus 5, P < .001). Furthermore, the duration of invasive ventilation in the HFOV-VG group also was lower than in the HFOV group (3.7 ± 1.2 days versus 2.1 ± 1.0 days, P < .01). Conclusion: Compared with HFOV alone, HFOV-VG decreases VThf levels and reduces the incidence of hypercapnia and hypocapnia in preterm infants with acute hypoxic respiratory failure after patent ductus arteriosus ligation.