65 results on '"Y. Lebranchu"'
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2. Avis sur l’attractivité des carrières hospitalo-universitaires
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Dominique Bertrand, Y. Lebranchu, O. Claris, J. Bringer, C. Buffet, D. Thuillez, and Francis Michot
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General Medicine - Published
- 2021
3. Conclusions sur les avancées en transplantation
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Y. Lebranchu
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General Medicine - Published
- 2022
4. Campylobacter infection in adult patients with primary antibody deficiency
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Jérémie Dion, Marion Malphettes, Lucie Bénéjat, Francis Mégraud, Alain Wargnier, David Boutboul, Lionel Galicier, Vincent Le Moing, Patrick Giraud, Arnaud Jaccard, Raphaële Nove-Josserand, Claire Fieschi, Eric Oksenhendler, Laurence Gérard, E. Oksenhendler, C. Fieschi, M. Malphettes, L. Galicier, S. Georgin, J.P. Fermand, J.F. Viallard, A. Jaccard, C. Hoarau, Y. Lebranchu, A. Bérezné, L. Mouthon, M. Karmochkine, N. Schleinitz, I. Durieu, R. Nove-Josserand, V. Chanet, V. Le-Moing, N. Just, C. Salanoubat, R. Jaussaud, F. Suarez, O. Hermine, P. Solal-Celigny, E. Hachulla, G. Condette-Wojtasik, L. Sanhes, M. Gardembas, I. Pellier, P. Tisserant, M. Pavic, B. Bonnotte, J. Haroche, Z. Amoura, L. Alric, M.F. Thiercelin, L. Tetu, D. Adoue, P. Bordigoni, T. Perpoint, P. Sève, P. Rohrlich, J.L. Pasquali, P. Soulas-Sprauel, L.J. Couderc, P. Giraud, A. Baruchel, I. Deleveau, F. Chaix, J. Donadieu, F. Tron, C. Larroche, A.P. Blanc, A. Masseau, M. Hamidou, G. Gorochov, J.L. Garnier, H. Moins, L. Gérard, Hôpital Saint-Louis, Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Université Paris Diderot - Paris 7 (UPD7), Recherche clinique appliquée à l'hématologie ((EA_3518)), Université Paris Diderot - Paris 7 (UPD7), Université de Bordeaux (UB), Recherches Translationnelles sur le VIH et les maladies infectieuses (TransVIHMI), Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Recherche pour le Développement (IRD)-Université Montpellier 1 (UM1)-Université Cheikh Anta Diop [Dakar, Sénégal] (UCAD)-Universtié Yaoundé 1 [Cameroun]-Université de Montpellier (UM), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Hopital Saint-Louis [AP-HP] (AP-HP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Recherche clinique appliquée à l'hématologie (URP_3518), Université de Paris (UP), Clinique Pont-de-Chaume, CHU Limoges, Centre Hospitalier Lyon Sud [CHU - HCL] (CHLS), Hospices Civils de Lyon (HCL), DEFI study group: E Oksenhendler, C Fieschi, M Malphettes, L Galicier, S Georgin, J P Fermand, J F Viallard, A Jaccard, C Hoarau, Y Lebranchu, A Bérezné, L Mouthon, M Karmochkine, N Schleinitz, I Durieu, R Nove-Josserand, V Chanet, V Le-Moing, N Just, C Salanoubat, R Jaussaud, F Suarez, O Hermine, P Solal-Celigny, E Hachulla, G Condette-Wojtasik, L Sanhes, M Gardembas, I Pellier, P Tisserant, M Pavic, B Bonnotte, J Haroche, Z Amoura, L Alric, M F Thiercelin, L Tetu, D Adoue, P Bordigoni, T Perpoint, P Sève, P Rohrlich, J L Pasquali, P Soulas-Sprauel, L J Couderc, P Giraud, A Baruchel, I Deleveau, F Chaix, J Donadieu, F Tron, C Larroche, A P Blanc, A Masseau, M Hamidou, G Gorochov, J L Garnier, H Moins, C Fieschi, M Malphettes, L Gérard, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Diderot - Paris 7 (UPD7), Recherches Translationnelles sur le VIH et les maladies infectieuses endémiques er émergentes (TransVIHMI), Université Montpellier 1 (UM1)-Institut de Recherche pour le Développement (IRD)-Université de Yaoundé I-Université Cheikh Anta Diop [Dakar, Sénégal] (UCAD)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), and Université Paris Diderot - Paris 7 (UPD7)-Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)
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Adult ,Male ,medicine.medical_specialty ,Gastrointestinal Diseases ,[SDV]Life Sciences [q-bio] ,Primary Immunodeficiency Diseases ,Population ,medicine.disease_cause ,Antibodies ,03 medical and health sciences ,0302 clinical medicine ,[SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases ,Internal medicine ,Campylobacter Infections ,medicine ,Prevalence ,Immunology and Allergy ,Humans ,030212 general & internal medicine ,education ,ComputingMilieux_MISCELLANEOUS ,education.field_of_study ,Univariate analysis ,business.industry ,Campylobacter ,Liver Diseases ,Middle Aged ,medicine.disease ,Comorbidity ,[SDV.MP.BAC]Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology ,3. Good health ,Diarrhea ,030228 respiratory system ,Bacteremia ,Coinfection ,Female ,France ,medicine.symptom ,business ,Complication ,[SDV.MHEP]Life Sciences [q-bio]/Human health and pathology - Abstract
International audience; Primary antibody deficiency (PAD) is characterized by a defective immunoglobulin production and recurrent infections, mostly involving respiratory and gastrointestinal tracts. Chronic or recurrent diarrhea is reported in up to 23%. Campylobacter infection is a common cause of infectious diarrhea, reported in 1.2% to 7.5% of patients with common variable immunodefi-ciency (CVID), the most frequent PAD. The aim of this study was to describe Campylobacter infection in patients with PAD included in a large nationwide study and analyze factors associ-ated with susceptibility to this pathogen. The DEFI (DEFicit Immunitaire) study is an ongoing large cross-sectional French multicentric study of adults with PAD, with retrospective collection of clinical data. All patients with a history of bacteriologically documented Campylobacter infection were identified, and clinical data were collected for each episode. Factors associated with recurrent infection were assessed as oddsratio (OR) and 95% confidence interval (CI), calculated by means of simple regression analysis. In patients with available material, strains of each episode were characterized using molecular analysis and compared (Table E1, available in this article’s Online Repository at www.jaci-inpractice.org). A com-parison of immunodeficiency-related characteristics of patients with and without Campylobacter infection was performed in the homogeneous group of patients with CVID. The control group included patients with CVID from DEFI centers who confirmed that patients did not develop Campylobacter infection after enrollment (Figure E1, available in this article’s Online Repository at www.jaci-inpractice.org). After correction for multiple comparisons, P
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- 2018
5. Discussion suite à la communication : « Greffe de rein d’un donneur vivant : bilan préparatoire et suivi du donneur »
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Y Lebranchu
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General Medicine - Published
- 2020
6. GENETIC DISEASES AND MOLECULAR GENETICS
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C. Legendre, D. Cohen, Y. Delmas, T. Feldkamp, D. Fouque, R. Furman, O. Gaber, L. Greenbaum, T. Goodship, H. Haller, M. Herthelius, M. Hourmant, C. Licht, B. Moulin, N. Sheerin, A. Trivelli, C. L. Bedrosian, C. Loirat, S. Babu, T. Jungraithmayr, Y. Lebranchu, M. Riedl, A. O. Gaber, C. Bedrosian, P. Muus, K. Douglas, G. Remuzzi, A. Kourouklaris, K. Ioannou, I. Athanasiou, K. Demetriou, A. Panagidou, M. Zavros, N. Y. Rodriguez C, M. Blasco, C. Arcal, L. F. Quintana, S. Rodriguez de Cordoba, J. M. Campistol, N. Bachmann, T. Eisenberger, C. Decker, H. J. Bolz, C. Bergmann, F. Pesce, S. N. Cox, G. Serino, G. De Palma, F. P. Sallustio, F. Schena, M. Falchi, M. Pieri, C. Stefanou, A. Zaravinos, K. Erguler, G. Lapathitis, H. Dweep, C. Sticht, N. Anastasiadou, I. Zouvani, K. Voskarides, N. Gretz, C. C. Deltas, A. Ruiz, O. Bonny, F. Sallustio, C. Curci, S. Cox, E. Kemter, S. Sklenak, B. Aigner, R. Wanke, T. M. Kitzler, J. L. Moskowitz, S. E. Piret, K. Lhotta, A. Tashman, E. Velez, R. V. Thakker, P. Kotanko, J. Leierer, M. Rudnicki, P. Perco, C. Koppelstaetter, G. Mayer, M. J. N. Sa, S. Alves, H. Storey, F. Flinter, P. J. Willems, F. Carvalho, J. Oliveira, M. Arsali, L. Papazachariou, P. Demosthenous, A. Lazarou, M. Hadjigavriel, C. Stavrou, L. Yioukkas, C. Deltas, A. Pierides, M. Kkolou, H. R. Toka, S. Dibartolo, B. Lanske, E. M. Brown, M. R. Pollak, A. Familiari, B. Zavan, S. Sanna Cherchi, A. Fabris, R. Cristofaro, G. Gambaro, A. D'Angelo, F. Anglani, H. Toka, D. Mount, M. Pollak, G. Curhan, G. Sengoge, T. Bajari, A. Kupczok, A. von Haeseler, M. Schuster, W. Pfaller, P. Jennings, A. Weltermann, S. Blake, G. Sunder-Plassmann, A. Kerti, R. Csohany, L. Wagner, E. Javorszky, E. Maka, T. Tulassay, K. Tory, J. Kingswood, N. Nikolskaya, J. Mbundi, S. Jozwiak, E. Belousova, M. Frost, R. Kuperman, M. Bebin, B. Korf, R. Flamini, M. Kohrman, S. Sparagana, J. Wu, T. Brechenmacher, K. Stein, J. Bissler, D. Franz, B. Zonnenberg, W. Cheung, J. Wang, D. Lam, K. Budde, L. Ivanitskiy, E. Sowershaewa, T. Krasnova, L. Samokhodskaya, M. Safarikova, R. Jana, S. Jitka, L. Obeidova, M. Kohoutova, V. Tesar, H. Evrengul, P. Ertan, E. Serdaroglu, S. Yuksel, S. Mir, E. Yang n Ergon, A. Berdeli, A. Zawada, K. Rogacev, B. Rotter, P. Winter, D. Fliser, G. Heine, S. Bataille, V. Moal, Y. Berland, L. Daniel, C. Rosado, E. Bueno, P. Fraile, C. Lucas, P. Garcoa-Cosmes, J. M. Tabernero, R. Gonzalez, P. Garcia-Cosmes, M. Silska-Dittmar, K. Zaorska, A. Malke, A. Musielak, D. Ostalska-Nowicka, J. Zachwieja, V. K d r, E. Uz, A. Yigit, A. Altuntas, B. Yigit, S. Inal, M. Sezer, R. Yilmaz, B. Visciano, C. Porto, E. Acampora, R. Russo, E. Riccio, I. Capuano, G. Parenti, A. Pisani, S. Feriozzi, A. Perrin, M. West, K. Nicholls, J. Torras, M. Cybulla, M. Conti, A. Angioi, M. Floris, P. Melis, A. M. Asunis, D. Piras, A. Pani, D. Warnock, A. Guasch, C. Thomas, C. Wanner, R. Campbell, B. Vujkovac, I. Okur, G. Biberoglu, F. Ezgu, L. Tumer, A. Hasanoglu, Z. Bicik, Y. Akin, M. Mumcuoglu, T. Ecder, C. Paliouras, G. Mattas, N. Papagiannis, G. Ntetskas, F. Lamprianou, N. Karvouniaris, and P. Alivanis
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Genetics ,Transplantation ,medicine.medical_specialty ,Nephrology ,business.industry ,Molecular genetics ,medicine ,business - Published
- 2014
7. TRANSPLANTATION BASIC SCIENCE, ALLOGENIC AND XENOGENIC TOLERANCE
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L. Berthelot, T. Robert, T. Tabary, V. Vuiblet, M. Drame, O. Toupance, P. Rieu, R. C. Monteiro, F. Toure, S. Ferrario, V. Cantaluppi, M. De Lena, S. Dellepiane, S. Beltramo, M. Rossetti, A. M. Manzione, M. Messina, M. Gai, C. Dolla, L. Biancone, G. Camussi, P. Pontrelli, A. R. Oranger, M. Accetturo, F. Rascio, M. Gigante, G. Castellano, A. Schena, M. Fiorentino, A. Zito, G. Zaza, G. Stallone, L. Gesualdo, G. Grandaliano, E. F. Pattonieri, M. Gregorini, V. Corradetti, C. Rocca, S. Milanesi, A. Peloso, J. Ferrario, M. Cannone, F. Bosio, N. Maggi, M. A. Avanzini, P. Minutillo, M. Paulli, M. Maestri, T. Rampino, A. Dal Canton, K. S. T. Wu, O. Coxall, Y. Luque, S. Candon, M. Rabant, L.-H. Noel, E. Thervet, L. Chatenoud, R. Snanoudj, D. Anglicheau, C. Legendre, J. Zuber, P. Hruba, I. Brabcova, E. Krepsova, J. Slatinska, A. Sekerkova, I. Striz, R. Zachoval, O. Viklicky, T. M. Scholbach, H.-K. Wang, C.-C. Loong, A.-H. Yang, T.-H. Wu, H. Guberina, V. Rebmann, P. Dziallas, S. Dolff, J. Wohlschlaeger, F. M. Heinemann, O. Witzke, Y. M. Zoet, F. H. J. Claas, P. A. Horn, A. Kribben, I. I. N. Doxiadis, N. Prasad, B. Yadav, V. Agarwal, A. Jaiswal, M. Rai, C. M. Hope, P. T. Coates, P. S. Heeger, R. Carroll, V. Masola, M. F. Secchi, M. Onisto, G. Gambaro, A. Lupo, M. Matsuyama, T. Kobayashi, Y. Yoneda, J. Chargui, J. L. Touraine, R. Yoshimura, D. Vizza, A. Perri, S. Lupinacci, G. Toteda, D. Lofaro, F. Leone, P. Gigliotti, A. La Russa, T. Papalia, R. Bonofilgio, A. Sentis Fuster, J. Kers, U. Yapici, N. Claessen, F. J. Bemelman, I. J. M. Ten Berge, S. Florquin, D. Glotz, L. Rostaing, J.-P. Squifflet, P. Merville, C. Belmokhtar, G. Le Ny, Y. Lebranchu, D. A. Papazova, M. Friederich-Persson, M. P. Koeners, J. A. Joles, M. C. Verhaar, H. L. Trivedi, A. V. Vanikar, S. D. Dave, B. Suarez Alvarez, S. Garcia Melendreras, R. Carvajal Palao, C. Diaz Corte, M. Ruiz Ortega, C. Lopez-Larrea, A. K. Yadav, D. Bansal, V. Kumar, M. Minz, V. Jha, D. Kaminska, K. Koscielska-Kasprzak, P. Chudoba, O. Mazanowska, M. Banasik, M. Zabinska, M. Boratynska, A. Lepiesza, K. Korta, M. Klinger, R. Csohany, A. Prokai, D. Pap, N. Balicza-Himer, A. Vannay, A. Fekete, K. Kis-Petik, J. Peti-Peterdi, A. Szabo, A. Masajtis-Zagajewska, K. Muras, M. Niewodniczy, M. Nowicki, J. Pascual, T. R. Srinivas, S. Chadban, F. Citterio, M. Henry, F. Oppenheimer, P.-C. Lee, H. Tedesco-Silva, M. Zeier, Y. Watarai, G. Dong, M. Hexham, P. Bernhardt, F. Vincenti, M. T. Rocchetti, J. Su owicz, A. Wojas-Pelc, E. Ignacak, K. Janda, M. Krzanowski, W. Su owicz, M. Mitsuhashi, T. Murakami, A. Benso, D. Leuning, M. Reinders, E. Lievers, J. Duijs, A. J. Van Zonneveld, C. Van Kooten, M. Engelse, T. Rabelink, A. Assounga, S. Omarjee, Z. Ngema, A. Ersoy, A. Gultepe, E. Isiktas Sayilar, H. Akalin, F. Coskun, M. Oner Torlak, Y. Ayar, M. Riegersperger, M. Plischke, C. Steinhauser, A. Jallitsch-Halper, G. Sengoelge, W. C. Winkelmayer, G. Sunder-Plassmann, M. Foedinger, M. Kaziuk, M. Kuz'Niewski, A. B Tkowska- Prokop, K. Pa Ka, P. Dumnicka, W. Kolber, and W. Su Owicz
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Transplantation ,medicine.medical_specialty ,Nephrology ,business.industry ,Basic science ,medicine ,Intensive care medicine ,business - Published
- 2014
8. Intravenous Immunoglobulins in the Prevention of Rejection of a Second or Third Kidney Graft
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J.-P. Squifflet, P. Merville, D. Glotz, Y. Lebranchu, and L. Rostaing
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Adult ,Graft Rejection ,Male ,Reoperation ,medicine.medical_specialty ,medicine.medical_treatment ,030232 urology & nephrology ,030204 cardiovascular system & hematology ,Kidney ,Gastroenterology ,03 medical and health sciences ,0302 clinical medicine ,Highly sensitized ,Internal medicine ,medicine ,Humans ,Adverse effect ,Kidney transplantation ,Immunosuppression Therapy ,Transplantation ,Graft rejection ,business.industry ,Graft Survival ,Immunoglobulins, Intravenous ,Immunosuppression ,Patient survival ,Middle Aged ,medicine.disease ,Kidney Transplantation ,medicine.anatomical_structure ,Intravenous Immunoglobulins ,Female ,Surgery ,business ,Immunosuppressive Agents - Abstract
Background Intravenous immunoglobulin (IVIg) reduces acute rejection episodes in kidney transplantation, but adverse events (AEs) are common. The aim of this study was to assess whether human IVIg enhances immunosuppressive effects without increasing AEs in the prevention of acute kidney graft rejection. Methods Patients receiving a second or third kidney graft were treated with standard immunosuppressant therapy with (n = 18) or without (n = 10) IVIg. The primary efficacy endpoint was biopsy-proven acute rejection (BPAR) rate at 3 months, and secondary endpoints included acute rejection rate at 12 months, intensity of rejection, and patient survival. Results Patients in the experimental arm received 3 infusions of IVIg. The BPAR rate decreased with IVIg versus standard immunosuppression alone over 12 months of follow-up. Experimental versus control rates of survival without BPAR were 94% versus 63% and 82% versus 63% at 3 and 12 months. The intensity of the acute rejection episodes (BANFF 97 grade) was similar between groups. One patient from each group died during the 12-month follow-up period. Treatment-emergent AEs were reported in 100% and 94.4% of the control and experimental arms. Most AEs were considered unrelated or unlikely to be related to treatment. Conclusions This study supports the efficacy and safety of IVIg in highly sensitized transplant patients for improving transplant rates and reducing graft rejection episodes.
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- 2018
9. Exclusion of Patients with a Severe T-Cell Defect Improves the Definition of Common Variable Immunodeficiency
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Rémi Bertinchamp, Laurence Gérard, David Boutboul, Marion Malphettes, Claire Fieschi, Eric Oksenhendler, E. Oksenhendler, C. Fieschi, M. Malphettes, L. Galicier, D. Boutboul, J.P. Fermand, J.F. Viallard, A. Jaccard, C. Hoarau, Y. Lebranchu, A. Bérezné, L. Mouthon, M. Karmochkine, N. Schleinitz, I. Durieu, R. Nove-Josserand, V. Chanet, V. Le-Moing, N. Just, C. Salanoubat, R. Jaussaud, F. Suarez, O. Hermine, P. Solal-Celigny, E. Hachulla, L. Sanhes, M. Gardembas, I. Pellier, P. Tisserant, M. Pavic, B. Bonnotte, J. Haroche, Z. Amoura, L. Alric, M.F. Thiercelin, L. Tetu, D. Adoue, P. Bordigoni, T. Perpoint, P. Sève, P. Rohrlich, J.L. Pasquali, A.S. Korganow, P. Soulas, L.J. Couderc, E. Catherinot, P. Giraud, A. Baruchel, I. Deleveau, F. Chaix, J. Donadieu, F. Tron, C. Larroche, A.P. Blanc, A. Masseau, M. Hamidou, G. Kanny, M. Morisset, F. Millot, O. Fain, R. Borie, A. Perlat, B. Bienvenue, B. Autran, G. Gorochov, J.L. Garnier, H. Moins, G. Maki, L. Gérard, Service d'Immunopathologie [Hôpital Saint-Louis, Paris], Hopital Saint-Louis [AP-HP] (AP-HP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Diderot - Paris 7 (UPD7), Recherche clinique appliquée à l'hématologie ((EA_3518)), Université Paris Diderot - Paris 7 (UPD7), Différenciation et progression tumorale des lymphocytes, École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut Universitaire d'Hématologie (IUH), Université Paris Diderot - Paris 7 (UPD7)-Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université Paris Diderot - Paris 7 (UPD7)-CHU Saint Louis [APHP], and École pratique des hautes études (EPHE)-Institut Universitaire d'Hématologie (IUH)
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0301 basic medicine ,Adult ,CD4-Positive T-Lymphocytes ,Male ,Pediatrics ,medicine.medical_specialty ,Opportunistic infection ,T cell ,Hypogammaglobulinemia ,Population ,Late onset combined immunodeficiency ,Opportunistic Infections ,03 medical and health sciences ,Agammaglobulinemia ,Overall survival ,Immunology and Allergy ,Medicine ,Immunodeficiency ,Humans ,[SDV.IMM.ALL]Life Sciences [q-bio]/Immunology/Allergology ,education ,education.field_of_study ,business.industry ,Common variable immunodeficiency ,CVID ,Definition ,Middle Aged ,medicine.disease ,Prognosis ,Confidence interval ,3. Good health ,Surgery ,CD4 Lymphocyte Count ,030104 developmental biology ,medicine.anatomical_structure ,Common Variable Immunodeficiency ,Female ,business - Abstract
International audience; BACKGROUND:In 2014, the European Society for Immune Deficiencies (ESID) revised the common variable immunodeficiency (CVID) diagnosis criteria by incorporating new clinical and biological markers. The new definition appeared more restrictive but had not yet been evaluated in a large cohort of patients.OBJECTIVE:The objective of this study was to evaluate the impact of this new definition in a large cohort of patients with primary hypogammaglobulinemia.METHODS:Evaluation of 3 different CVID definitions (ESID/Pan-American Group for Immunodeficiency [PAGID] 1999, ESID 2014, DEFI 2015) in 521 patients included in the French DEFI study with a diagnosis of primary hypogammaglobulinemia.RESULTS:Using the ESID/PAGID 1999 definition, 351 patients were classified as CVID. The new ESID 2014 definition excluded 62 (18%) patients. Most of them (n = 56; 90%) had a less severe disease, whereas 6 (10%) presented with a severe disease with major T-cell defect. We propose different criteria (occurrence of opportunistic infection or very low naive CD4+ T-cell count) to define this population with severe T-cell defect. Sixty-two patients fulfilled these criteria, represented 20% of the initial CVID population but accounted for 77% of the deaths, with a 5-year overall survival of 67.6% (95% confidence interval, 51.0-79.6), and were considered as late onset combined immunodeficiency (LOCID).CONCLUSIONS:The new ESID definition for CVID still fails to exclude a large number of patients with severe T-cell defect. We propose a new definition (DEFI 2015) that excluded more patients with a T-cell defect and consider these patients as LOCID. This population has a poor outcome and should be considered as a distinct group requiring specific care.
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- 2016
10. New technology in immunology (PP-063)
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N. Babel, Y. Kobayashi, S. Shojaeian, Y. Aiki, H. Hiroyuki, S. Shin, C. Constantin, L. Yang, M. Magari, M. Zarkawi, T. T. Ngo, H. Kakita, V. V. Feoktistoff, H. Yagita, A. Arranz, S. Massaro, E. Kobayashi, K. Tajiri, D. Suzuki, J. Aishun, J. Y. Huang, U. Birk, L. Hwang, G. Kesa, T. Wu, K. Nagata, N. Ahlborg, Y. Tokura, A. Kosaka, M. H. Hussein, S. Hristescu, H. Okada, S. Badar, A. Abbady, K. Matsuoka, T. Mizushima, T. Watanabe, H. Suemizu, K. Jacobsen, I. Kato, Y. Tabata, T. Sawasaki, E. Sasaki, H. Ohmori, Z. Lin, T. T. Radzivil, M. Satake, S. Klages, A. Sarasa-Renedo, G. H. Daoud, N. Masataka, T. Jakobsen, K. Tani, B. Hur, M. Kohler, K. Pollinger, S. Hatakeyama, S. Sevinc, M. Suntravat, S. Fujii, H. Choi, T. Obata, A. A. Vasilyev, M. Gharagozloo, N. Tamaoki, Y. Lebranchu, S. Suzuki, M. Nose, J. Ma, J. Hecht, T. Corona-Ortega, D. Halbritter, I. Ishida, T. Sugiyama, A. A. Omran, R. Favicchio, A. M. A. Shihata, M. Lye, N. Okayama, A. Ghaderi, A. I. Sukhanov, A. Jin, S. Song, A. Muraguchi, H. Kishi, J. Ripoll, A. Al-Mariri, T. Kato, T. Ito, S. Paulie, A. K. Verma, H. Volk, L. Brix, L. Ayers, A. Planas, S. Habu, K. Sekikawa, I. Del rio-Ortiz, Y. Ong, Z. Mojtahedi, A. Thiel, M. Nobata, G. Mittler, C. Schütz, M. Nakamura, G. Zacharakis, K. Orihara, Y. Fujiwara, T. Ozawa, S. Kato, K. Mnasria, M. Dziubianau, J. Aguirre, R. Ion, H. Komori, C. Tei, S. Matsuda, T. Suguria, J. Schøller, S. Kojima, H. Takaiwa, D. Kioussis, M. Saber Firouzi, M. Abebe, M. Neagu, A. Göpferich, E. Torkabadi, V. Kumar, H. M. Vijay, H. Togari, C. Mamalaki, R. Oba, J. Williams, S. Hamasaki, K. Masjedi, P. Reinke, A. Koyanagi, A. H. Zarnani, Y. Kanehiro, Z. Bartek, C. Crowley, J. Sarvari, A. Y. El-Sayeda, M. Fleck, H. Mizuno, H. R. Mirzaei, M. Jeddi-Tehrani, A. Sattler, K. Kitamura, R. Reinhardt, K. Lee, N. Kanayama, C. Tsatsanis, I. Nuchprayoon, A. Rezaei, C. Lagaraine, K. Shiraki, R. Rangel-Corona, K. Todo, N. M. Tsuji, T. Goto, S. Cha, A. Martin, R. Oueslati, M. Kito, Y. Endo, Y. Kametani, B. Ferry, B. Weiss-Steider, K. Inoue, M. Shahrabadi, S. Muyldermans, N. Okada, A. A. Allameh, and S. Malek Hosini
- Subjects
Engineering ,business.industry ,Immunology ,Immunology and Allergy ,Library science ,General Medicine ,business - Published
- 2010
11. Difficultés de la prise en charge d’une forme pulmonaire isolée du syndrome de Goodpasture
- Author
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A. Legras, Y. Lebranchu, M. Marcq, G. Mouteaux, C. Barbet, J. Buret, and Patrice Diot
- Subjects
Pulmonary and Respiratory Medicine - Abstract
Introduction Le diagnostic des formes pulmonaires pures du syndrome de Goodpasture n’est pas aise et il faut discuter une ponction biopsie renale en cas de negativite des anticorps anti- membrane basale glomerulaire car l’evolution peut se faire spontanement vers une hemorragie intra-alveolaire massive pouvant etre fatale. Le traitement des formes pneumo renales associant corticoides, cyclophosphamide et echanges plasmatiques doit etre applique aux formes pulmonaires pour maitriser l’hemorragie et prevenir une recidive precoce. Observation Nous rapportons ici le cas d’un patient atteint d’un syndrome de Goodpasture a forme pulmonaire pure ou le diagnostic a ete retarde par la negativite du premier dosage des anticorps en immunofluorescence indirecte. Apres une rechute precoce et grave, la remission a ete obtenue grâce a un traitement complet et un sevrage tabagique. Conclusion Si le diagnostic est fait sans retard et que le traitement est conduit de facon complete, le pronostic de ces patients reste bon avec 80 a 90 % de guerison.
- Published
- 2008
12. Anti-CD25 Antibodies Decrease the Ability of Human Dendritic Cells to Prime Allogeneic CD4 T Cells
- Author
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Christine Lagaraine, Florence Velge-Roussel, Christophe Baron, K. Mnasria, and Y. Lebranchu
- Subjects
CD4-Positive T-Lymphocytes ,Graft Rejection ,medicine.drug_class ,CD40 Ligand ,Immunoglobulins ,chemical and pharmacologic phenomena ,Lymphocyte Activation ,Monoclonal antibody ,Monocytes ,Antigens, CD ,medicine ,Humans ,Transplantation, Homologous ,IL-2 receptor ,CD40 Antigens ,Antigen-presenting cell ,CD86 ,Transplantation ,Membrane Glycoproteins ,CD40 ,biology ,business.industry ,Interleukin-2 Receptor alpha Subunit ,hemic and immune systems ,Dendritic Cells ,HLA-DR Antigens ,Dendritic cell ,Antibodies, Anti-Idiotypic ,Acute Disease ,CD4 Antigens ,Immunology ,B7-1 Antigen ,biology.protein ,Surgery ,B7-2 Antigen ,business ,CD80 - Abstract
Anti-CD25 monoclonal antibodies are largely used in clinical transplantation to prevent acute allograft rejection episodes. Although their effects on T lymphocytes have been extensively studied, their impact on human dendritic cells (DCs) has been less reported. Furthermore, the role of the interleukin-2 in DC functions has not yet been fully elucidated. In this study, we observed that stimulation of human monocyte-derived DCs with lipopolysa ccharide or CD40L strongly induced the expression of CD25. We showed that pretreatment of DC with anti-CD25 diminished their ability to prime T-helper cells. In contrast, humanized anti-CD25 monoclonal antibodies did not affect the up-regulation of CD86, CD80, CD83, HLA-DR, or CD40 induced by lipopolysaccharide stimulation. This study supported previously unrecognized effects of anti-CD25 monoclonal antibodies on DCs that may contribute to their clinical efficacy.
- Published
- 2009
13. New Approaches to De Novo Immunosuppression and Steroid Elimination
- Author
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Y. Lebranchu
- Subjects
Graft Rejection ,medicine.medical_specialty ,medicine.drug_class ,medicine.medical_treatment ,T-Lymphocytes ,Biopsy ,Calcineurin Inhibitors ,Urology ,Renal function ,Lymphocyte Depletion ,Adrenal Cortex Hormones ,Transplantation Immunology ,Medicine ,Humans ,Kidney transplantation ,Antilymphocyte Serum ,Immunosuppression Therapy ,Sirolimus ,Transplantation ,business.industry ,Antibodies, Monoclonal ,Immunosuppression ,medicine.disease ,Kidney Transplantation ,Surgery ,Calcineurin ,Regimen ,Treatment Outcome ,Cyclosporine ,Corticosteroid ,Steroids ,business ,Immunosuppressive Agents ,medicine.drug ,Glomerular Filtration Rate - Abstract
Calcineurin inhibitors (CNIs) and steroids, the cornerstone of most immunosuppressive regimens in the past 20 years, have undesirable long-term side effects. This has led to the investigation of potential new strategies with sirolimus (SRL) and mycophenolate mofetil (MMF). In the SPIESSER study, de novo CNI avoidance and early steroid withdrawal were evaluated in 145 renal recipients randomized to receive either SRL (n = 71) or cyclosporine (CsA; n = 74). All patients received polyclonal anti-thymocyte globulin (ATG) for 5 days, MMF, and steroids withdrawn at 6 months. At 12 months, patient and graft survival, incidence of biopsy-proven acute rejection (BPAR), and rates of steroid withdrawal were not statistically different (97% vs 97%, 90% vs 93%, 14.3% vs 8.6%, and 82.8% vs 84.1%, respectively). In patients who remained on treatment according to the protocol, estimated glomerular filtration rate (eGFR) was significantly higher with SRL (69 +/- 19 vs 60 +/- 14 mL/min; P.01). In the CONCEPT study, early conversion from CsA to SRL was evaluated. One hundred ninety-two renal recipients were prospectively randomized at week 12 to switch from CsA to SRL (n = 95) or to continue CsA (n = 97). At 12 months, patient survival rates (100% vs 100%) and graft survival rates (100% vs 98%), incidence of acute rejection (17% vs 8%), and rates of steroid withdrawal (72% vs 78%) were not significantly different between the SRL and the CsA groups. eGFR was significantly higher with SRL (68.9 vs 64.4 mL/min; P = .017; intent-to-treat analysis). In both studies, a significant improvement in renal function was observed at 12 months in patients receiving a maintenance regimen with SRL and MMF. In addition, steroids could be withdrawn in 70% of these patients.
- Published
- 2008
14. Neuromyopathie toxique induite par la ciclosporine
- Author
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Y. Lebranchu, A. Al-Najjar, P. Corcia, A.-M. Guennoc, A. M. Bergemer-Fouquet, B. de Toffol, and Alain Autret
- Subjects
Neurology ,Neurology (clinical) - Abstract
Resume Introduction La ciclosporine est un medicament immunosuppresseur majeur dans la prevention de rejet des greffes et dans certaines affections auto-immunes. La prescription de cette molecule est limitee par de nombreux effets parmi lesquels on note des cas de neuropathies et de myopathies, rapportees notamment lorsque la ciclosporine est associee a des medicaments inhibant la co-enzyme A reductase. Observation Nous rapportons le cas d’une patiente de 67 ans qui a developpe quelques mois apres une greffe renale un deficit sensitivo-moteur rapidement evolutif en rapport avec une neuromyopathie. Bien que la ciclosporine fut prescrite seule dans les taux therapeutiques, l’elimination des autres etiologies responsables d’un tel tableau conduisait a privilegier l’hypothese d’une toxicite induite exclusivement par la ciclosporine. Cette hypothese fut confirmee par l’amelioration de l’etat neurologique apres arret de cette prescription. Conclusion Cette observation souligne donc la neurotoxicite potentielle de la ciclosporine meme lorsqu’elle est prescrite en monotherapie aux taux therapeutiques.
- Published
- 2005
15. Transplantation et transfert d’allergie
- Author
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Y. Lebranchu and C. Hoarau
- Subjects
business.industry ,Medicine ,Dermatology ,business - Published
- 2004
16. Epidemiology of posttransplant lymphoproliferative disorders in adult kidney and kidney pancreas recipients: report of the French registry and analysis of subgroups of lymphomas
- Author
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S, Caillard, F X, Lamy, C, Quelen, J, Dantal, Y, Lebranchu, P, Lang, M, Velten, B, Moulin, and M, Buchler
- Subjects
Adult ,Graft Rejection ,Male ,medicine.medical_specialty ,Adolescent ,Lymphoma ,medicine.medical_treatment ,Lymphoproliferative disorders ,Pancreas transplantation ,Gastroenterology ,Young Adult ,Postoperative Complications ,Risk Factors ,hemic and lymphatic diseases ,Internal medicine ,medicine ,Immunology and Allergy ,Humans ,Pharmacology (medical) ,Cumulative incidence ,Registries ,Kidney transplantation ,Transplantation ,business.industry ,Incidence (epidemiology) ,Incidence ,Hazard ratio ,Immunosuppression ,Middle Aged ,medicine.disease ,Kidney Transplantation ,Lymphoproliferative Disorders ,surgical procedures, operative ,Immunology ,Female ,France ,Pancreas Transplantation ,business - Abstract
A registry of posttransplant lymphoproliferative disorders (PTLD) was set up for the entire population of adult kidney transplant recipients in France. Cases of PTLD were prospectively enrolled between January 1, 1998, and December 31, 2007. Ten-year cumulative incidence was analyzed in patients transplanted after January 1, 1989. PTLD risk factors were analyzed in patients transplanted after January 1, 1998 by Cox analysis. Cumulative incidence was 1% after 5 years, 2.1% after 10 years. Multivariate analysis showed that PTLD was significantly associated with: older age of the recipient 47-60 years and >60 years (vs. 33-46 years, adjusted hazard ratio (AHR) = 1.87, CI = 1.22-2.86 and AHR = 2.80, CI = 1.73-4.55, respectively, p < 0.0001), simultaneous kidney-pancreas transplantation (AHR = 2.52, CI = 1.27-5.01 p = 0.008), year of transplant 1998-1999 and 2000-2001 (vs. 2006-2007, AHR = 3.36, CI = 1.64-6.87 and AHR = 3.08, CI = 1.55-6.15, respectively, p = 0.003), EBV mismatch (HR = 5.31, CI = 3.36-8.39, p < 0.001), 5 or 6 HLA mismatches (vs. 0-4, AHR = 1.54, CI = 1.12-2.12, p = 0.008), and induction therapy (AHR = 1.42, CI = 1-2.02, p = 0.05). Analyses of subgroups of PTLD provided new information about PTLD risk factors for early, late, EBV positive and negative, polymorphic, monomorphic, graft and cerebral lymphomas. This nationwide study highlights the increased risk of PTLD as long as 10 years after transplantation and the role of cofactors in modifying PTLD risk, particularly in specific PTLD subgroups.
- Published
- 2012
17. In VitroInhibitory Effect of Docosahexaenoic and Eicosapentaenoic Acids on Human Endothelial Cell Production of Interleukin-6
- Author
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P Bardos, P. Y. Sizaret, Y. Lebranchu, J. F. Valentin, Yves Gruel, Gilles Thibault, H. Watier, and B. Khalfoun
- Subjects
chemistry.chemical_classification ,Physiology ,medicine.medical_treatment ,Cell Biology ,General Medicine ,Pharmacology ,Biology ,Eicosapentaenoic acid ,Endothelial stem cell ,chemistry.chemical_compound ,Cytokine ,Biochemistry ,chemistry ,Docosahexaenoic acid ,biology.protein ,medicine ,lipids (amino acids, peptides, and proteins) ,Arachidonic acid ,Interleukin 6 ,Interleukin 4 ,Polyunsaturated fatty acid - Abstract
The interaction between lymphocytes, cytokines, and endothelial cells (EC) is a key step in the inflammatory process. Interleukin-6 (IL-6), a pleiotropic cytokine in its effects, seems to be an early indicator of acute systemic inflammation. We examined the effects of polyunsaturated fatty acids (PUFA) on the production of IL-6 by human unstirnulated EC and by EC stimulated with TNF-α (100U/ml), IL-4 (100U/ml), LPS (1 μg/ml), or allogeneic peripheral blood lymphocytes (PBL). Immunoreactive IL-6 of twenty-four hour culture Supernatants was measured by sandwich ELISA. We demonstrated that the production of IL-6 was potentiated when EC were stimulated with TNF-α, IL-4, LPS, or monocyte-depleted PBL in comparison to unstimulated EC. The addition of n-3 PUFA to the culture medium (100 pglml DHA or EPA) significantly reduced the production of IL-6 by unstimulated EC and by EC stimulated with TNF-α, IL4, LPS or depleted PBL, whereas the n-6 PUFA (Arachidonic acid), even used at a similar concentration, was ineff...
- Published
- 1994
18. IL-4, but not tumor necrosis factor-alpha, increases endothelial cell adhesiveness for lymphocytes by activating a cAMP-dependent pathway
- Author
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P Galéa, G Thibault, M Lacord, P Bardos, and Y Lebranchu
- Subjects
Immunology ,Immunology and Allergy - Abstract
IL-4 and TNF-alpha increase endothelial cell adhesiveness for PBL by promoting the expression of adhesion molecules. We investigated the intracellular cAMP involvement in the increased endothelial cell adhesivity induced by IL-4 or TNF-alpha. We showed that both IL-4 and TNF-alpha increased intracellular cAMP in endothelial cells (EC). Furthermore, dibutyryl-cAMP and forskolin (which increased intracellular cAMP) increased basic EC adhesivity for PBL. The co-stimulation of EC with cAMP elevating agents and TNF-alpha, but not IL-4, resulted in an additive increase in EC adhesiveness. 2',5' dideoxyadenosine, an inhibitor of adenylate cyclase, decreased PBL adhesion to IL-4- but not TNF-alpha-treated EC. Similarly, HA1004, a protein kinase A inhibitor, totally reversed the IL-4 but not TNF-alpha effect on EC adhesiveness, whereas H7, a protein kinase C inhibitor, did not antagonise cytokine-enhanced EC adhesivity. These results indicate that IL-4, but not TNF-alpha, uses a cAMP-dependent pathway to increase PBL adhesion. Furthermore, we showed that cAMP elevation in EC did not induce vascular cell adhesion molecule 1, the only identified adhesion molecule induced by IL-4, indicating that a rise in cAMP in EC promotes an as yet unidentified adhesion pathway. Our results show that IL-4 increases EC adhesiveness for PBL through activation of protein kinase A by promoting an unidentified adhesion pathway.
- Published
- 1993
19. Can we eliminate both calcineurin inhibitors and steroids?
- Author
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Y. Lebranchu
- Subjects
Graft Rejection ,medicine.medical_specialty ,Time Factors ,Calcineurin Inhibitors ,Urology ,Renal function ,Mycophenolate ,Risk Assessment ,Steroid withdrawal ,Drug Administration Schedule ,Internal medicine ,medicine ,Humans ,Transplantation, Homologous ,In patient ,Sirolimus ,Transplantation ,business.industry ,Incidence (epidemiology) ,Graft Survival ,Mycophenolic Acid ,Kidney Transplantation ,Calcineurin ,Regimen ,Endocrinology ,Treatment Outcome ,Cyclosporine ,Surgery ,Drug Therapy, Combination ,Steroids ,business ,Immunosuppressive Agents ,medicine.drug - Abstract
Calcineurin inhibitors (CNIs) and steroids, the cornerstone of most immunosuppressive regimens in the past 20 years, have undesirable chronic effects. This has led to the use of new strategies with sirolimus (SRL) and mycophenolate mofetil (MMF). In the SPIESSER study, de novo CNI avoidance and early steroid withdrawal were evaluated in 145 renal recipients randomized to receive either SRL (n = 71) or cyclosporine (CsA; n = 74). All patients received polyclonal antithymocyte globulin for 5 days, MMF, and steroids withdrawn at 6 months. At 12 months, the incidence of biopsy-proven acute rejection was low (14.3% for SRL vs 8.6% for CsA). At 3 years, renal function (Nankivell) was better in the SRL group, particularly in patients who remained on treatment according to the protocol (71 ± 22 vs 60 ± 17 mL/min; P < .01). Steroids were withdrawn in 70.5% of SRL-treated patients and in 66.7% of CsA-treated patients. In the CONCEPT study, early conversion from CsA to SRL was evaluated in 192 renal recipients prospectively randomized at week 12 to switch from CsA to SRL (n = 95) or to continue CsA (n = 97). At 12 months, estimated glomerular filtration rate (Modification of Diet in Renal Disease) was significantly higher with SRL (61 ± 16 vs 54 ± 15 mL/min; P = .002, intent-to-treat analysis). The significant improvement in renal function was maintained at 30 months. In both studies graft and patient survival were similar, with better renal function and a tendency for fewer cancers observed at follow-up in patients receiving a maintenance regimen with SRL and MMF. At 30 months, steroids had been withdrawn in 72% of SRL-treated patients and in 70% of CsA-treated patients.
- Published
- 2010
20. Impact of a polymorphism in the IL-12p40 gene on the outcome of kidney transplantation
- Author
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Thomas W Hoffmann, Florence Velge-Roussel, Mathias Büchler, Christophe Baron, J.-F. Marlière, Jean-Michel Halimi, A. Al-Najjar, and Y. Lebranchu
- Subjects
Graft Rejection ,Pathology ,medicine.medical_specialty ,Genotype ,Single-nucleotide polymorphism ,Biology ,Polymorphism, Single Nucleotide ,White People ,Risk Factors ,medicine ,Cadaver ,SNP ,Humans ,Allele ,3' Untranslated Regions ,Kidney transplantation ,Transplantation ,Polymorphism, Genetic ,Interleukin-12 Subunit p40 ,Graft Survival ,Odds ratio ,medicine.disease ,Kidney Transplantation ,Tissue Donors ,Treatment Outcome ,Immunology ,Cytomegalovirus Infections ,Surgery ,Restriction fragment length polymorphism - Abstract
A number of factors interfere with the outcome of renal transplantation. Revealing genetic factors that impact on graft outcome may have consequences for clinical practice. Interleukin-12 (IL-12), by stimulating interferon gamma (IFNγ) production, plays a crucial role in immune responses against both graft and viral agents. An A-to-C single nucleotide polymorphism (SNP) within the 3′-untranslated region (3′UTR) of the IL-12p40 gene has been reported to be both functionally and clinically relevant. Since the impact of this SNP on kidney graft outcome has never been reported, we investigated the impact of the 3′UTR polymorphism on clinical events after transplantation among 253 kidney recipients transplanted between 1995 and 2003. The polymorphism was genotyped using the restriction fragment length polymorphism method. Our results showed that the 3′UTR polymorphism affected neither graft survival ( P = .768) nor the occurrence of delayed graft function (DGF; P = .498). C allele carriers in our study displayed more acute rejections in the first year than patients with the A/A genotype, but it did not reach statistical significance ( P = .108). In contrast, the C allele appeared to be a significant risk factor for cytomegalovirus infection (odds ratio = 1.77; P = .027). In conclusion, IL12B 3′UTR polymorphism did not affect graft survival, DGF, or acute rejection episodes, but had an impact on the occurrence of cytomegalovirus infection.
- Published
- 2009
21. Treatment of Post-Transplant B-Cell Lymphomas with Monoclonal Chimeric Anti-B-Cell Antibodies
- Author
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J. L. Garnier, P. Deteix, J. Dantal, Y. Lebranchu, G. Stevenson, E. Alamartine, and D. Glotz
- Subjects
Chemotherapy ,biology ,medicine.drug_class ,business.industry ,medicine.medical_treatment ,Immunosuppression ,Monoclonal antibody ,Phenotype ,medicine.anatomical_structure ,immune system diseases ,hemic and lymphatic diseases ,Monoclonal ,medicine ,Cancer research ,biology.protein ,Antibody ,business ,Monoclonal antibody therapy ,B cell - Abstract
Treatment of post-transplant B-cell lymphomas has proved to be difficult because the decrease of the immunosuppressive therapy can lead to rejection and chemotherapy is hazardous. Anti-CD21/24 monoclonal antibody therapy has previously offered the advantages of a good tolerance and efficiency on oligoclonal lymphomas. With a better knowledge of the phenotype of post-transplant lymphomas, we tried to develop chimeric monoclonal antibodies (mAb) that could be more efficient on the lymphomas and could permit to keep the immunosuppression in order to avoid graft loss.
- Published
- 2007
22. Fibrinolytic status of the normal human fetus: association with undetectable levels of histidin-rich glycoprotein and lipoprotein(a)
- Author
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P Reverdiau-Moalic, Yves Gruel, V. Billaud, P. Bardos, G. Body, and Y. Lebranchu
- Subjects
chemistry.chemical_classification ,medicine.medical_specialty ,Fetus ,Low-density lipoprotein receptor-related protein 8 ,biology ,business.industry ,Hematology ,Lipoprotein(a) ,Endocrinology ,chemistry ,Internal medicine ,medicine ,biology.protein ,Glycoprotein ,business - Published
- 1996
23. PRK15 A SURVEY ON THE CLINICAL MANAGEMENT OF CMV RISK IN PATIENTS FOLLOWING RENAL TRANSPANTATION IN FRANCE
- Author
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C Legendre, I Durand-Zaleski, Y Lebranchu, C Pouteil-Noble, S Beard, J Ratcliffe, and A Crochard
- Subjects
medicine.medical_specialty ,business.industry ,Health Policy ,medicine ,Public Health, Environmental and Occupational Health ,In patient ,Intensive care medicine ,business - Published
- 2002
- Full Text
- View/download PDF
24. Recipient TNFRSF6 (FAS) gene polymorphism and acute renal allograft rejection
- Author
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M. Ngourn, M. Büchler, S. Cappellesso, Jean-Michel Halimi, A. Al-Najjar, Y. Lebranchu, P. Bardos, J.F. Valentin, H. Watier, and H. Nivet
- Subjects
Graft Rejection ,Urinary system ,Biology ,Polymorphism, Single Nucleotide ,Fas ligand ,medicine ,Humans ,fas Receptor ,Gene ,Kidney transplantation ,Retrospective Studies ,Transplantation ,Kidney ,Polymorphism, Genetic ,Fas receptor ,medicine.disease ,Kidney Transplantation ,medicine.anatomical_structure ,Enhancer Elements, Genetic ,Immunology ,Acute Disease ,Renal allograft ,Surgery ,Drug Therapy, Combination ,Immunosuppressive Agents - Published
- 2002
25. Induction versus noninduction in renal transplant recipients with tacrolimus-based immunosuppression
- Author
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G, Mourad, V, Garrigue, J P, Squifflet, T, Besse, F, Berthoux, E, Alamartine, D, Durand, L, Rostaing, P, Lang, C, Baron, D, Glotz, C, Antoine, P, Vialtel, T, Romanet, Y, Lebranchu, A, Al Najjar, C, Hiesse, L, Potaux, P, Merville, J L, Touraine, N, Lefrancois, M, Kessler, E, Renoult, C, Pouteil-Noble, R, Cahen, C, Legendre, J, Bedrossian, P, Le Pogamp, J, Rivalan, M, Olmer, R, Purgus, F, Mignon, B, Viron, and B, Charpentier
- Subjects
Adult ,Graft Rejection ,Male ,Incidence ,Graft Survival ,Drug Resistance ,Middle Aged ,Kidney ,Kidney Transplantation ,Tacrolimus ,Humans ,Female ,Steroids ,Immunosuppressive Agents ,Antilymphocyte Serum ,Retrospective Studies - Abstract
The aim of this study was to compare the efficacy and safety of induction treatment with antithymocyte globulins (ATG) followed by tacrolimus therapy with immediate tacrolimus therapy in renal transplant recipients.This 12-month, open, prospective study was conducted in 15 centers in France and 1 center in Belgium; 309 patients were randomized to receive either induction therapy with ATG (n=151) followed by initiation of tacrolimus on day 9 or immediate tacrolimus-based triple therapy (n=158). In both study arms, the initial daily tacrolimus dose was 0.2 mg/kg. Steroid boluses were given in the first 2 days and tapered thereafter from 20 mg/day to 5 mg/day. Azathioprine was administered at 1-2 mg/kg per day.At month 12, biopsy-confirmed acute rejections were reported for 15.2% (induction) and 30.4% (noninduction) of patients (P=0.001). The incidence of steroid-sensitive acute rejections was 7.9% (induction) and 22.2% (noninduction)(P=0.001). Steroid-resistant acute rejections were reported for 8.6% (induction) and 8.9% (noninduction) of patients. A total of nine patients died. Patient survival and graft survival at month 12 was similar in both treatment groups (97.4% vs. 96.8% and 92.1% vs. 91.1%, respectively). Statistically significant differences in the incidence of adverse events were found for cytomegalovirus (CMV) infection (induction, 32.5% vs. noninduction, 19.0%, P=0.009), leukopenia (37.3% vs. 9.5%, P0.001), fever (25.2% vs. 10.1%, P=0.001), herpes simplex (17.9% vs. 5.7%, P=0.001), and thrombocytopenia (11.3% vs. 3.2%, P=0.007). In the induction group, serum sickness was observed in 10.6% of patients. The incidence of new onset diabetes mellitus was 3.4% (induction) and 4.5% (noninduction).Low incidences of acute rejection were found in both treatment arms. Induction treatment with ATG has the advantage of a lower incidence of acute rejection, but it significantly increases adverse events, particularly CMV infection.
- Published
- 2001
26. Induction of Jurkat T-cell apoptosis by Fas ligand-transfected endothelial cells
- Author
-
S. Cappellesso, G. Thibault, Y Lebranchu, H. Watier, C Hoarau, and P Bardos
- Subjects
Programmed cell death ,Fas Ligand Protein ,Cell Survival ,T-Lymphocytes ,Apoptosis ,Biology ,Lymphocyte Activation ,Transfection ,Jurkat cells ,Fas ligand ,Jurkat Cells ,Humans ,fas Receptor ,Transplantation ,Membrane Glycoproteins ,Genetic transfer ,Molecular biology ,Coculture Techniques ,Recombinant Proteins ,Endothelial stem cell ,Cell culture ,Immunology ,Surgery ,Endothelium, Vascular - Published
- 2001
27. Double-blind comparison of two corticosteroid regimens plus mycophenolate mofetil and cyclosporine for prevention of acute renal allograft rejection
- Author
-
Y, Vanrenterghem, Y, Lebranchu, R, Hené, F, Oppenheimer, and H, Ekberg
- Subjects
Adult ,Graft Rejection ,Male ,Adolescent ,Middle Aged ,Mycophenolic Acid ,Kidney Transplantation ,Double-Blind Method ,Adrenal Cortex Hormones ,Cyclosporine ,Humans ,Drug Therapy, Combination ,Female ,Immunosuppressive Agents - Abstract
Renal transplant recipients experience adverse events attributed to corticosteroid therapy.This was a multicenter, randomized, double-blind, 6-month, controlled steroid dose-reduction study in renal transplant recipients with an unblinded 6-month follow-up. In the low/stop arm, corticoste. roids were given at half the dosage of control for 3 months from the date of transplantation, and then withdrawn. Both arms received mycophenolate mofetil and cyclosporine. The primary endpoint was the incidence of biopsy-proven acute rejection at 6 months posttransplantation.There were 248 patients in the control group and 252 in the low/stop group. At 6 months the low/stop group had more biopsy-proven acute rejection episodes than the control (23% vs. 14%; P=0.008). At 12 months this increased to 25% vs. 15%. Most rejections were Banff grade I. Twelve-month graft loss was 5% in the low/stop group vs. 4% in the control. At 6 and 12 months serum cholesterol (P0.01, P0.01), triglycer. ides (P0.01, P0.01), and systolic blood pressure (P0.001, P0.001) were lower in the low/stop group. Diastolic pressure was lower (P0.01) and lumbar spine bone density was greater (P0.01) in the low/ stop group at 12 months.In renal transplant recipients treated with mycophenolate mofetil and cyclosporine, reduction and early withdrawal of the prophylactic corticosteroid dose is feasible without an unacceptable increase in serious rejection episodes. This is accompanied by a significant reduction of steroid-related adverse events.
- Published
- 2000
28. Sirolimus in association with mycophenolate mofetil induction for the prevention of acute graft rejection in renal allograft recipients
- Author
-
H, Kreis, J M, Cisterne, W, Land, L, Wramner, J P, Squifflet, D, Abramowicz, J M, Campistol, J M, Morales, J M, Grinyo, G, Mourad, F C, Berthoux, C, Brattström, Y, Lebranchu, and P, Vialtel
- Subjects
Adult ,Graft Rejection ,Male ,Sirolimus ,Adolescent ,Dose-Response Relationship, Drug ,Middle Aged ,Mycophenolic Acid ,Kidney Transplantation ,Acute Disease ,Cyclosporine ,Humans ,Transplantation, Homologous ,Drug Therapy, Combination ,Female ,Child ,Immunosuppressive Agents ,Aged - Abstract
A previous trial in renal transplantation comparing sirolimus (rapamycin) to cyclosporine (CsA) in a triple-drug therapy regimen with azathioprine and corticosteroids found that the incidence of acute rejection was similar (approximately 40%) with a trend for better renal function with sirolimus.In 14 European centers, first cadaveric renal allograft recipients were randomized to receive sirolimus (n = 40) or CsA (n = 38) in an open-label design. All patients received corticosteroids and mycophenolate mofetil 2 g/day. Sirolimus and CsA were concentration controlled; trough levels of mycophenolic acid and prednisolone were also measured.At 12 months, graft survival (92.5% sirolimus vs. 89.5% CsA), patient survival (97.5% sirolimus vs. 94.7% CsA), and the incidence of biopsy-proven acute rejection (27.5% sirolimus vs. 18.4% CsA) were not statistically different. The use of antibodies to treat suspected rejection episodes was also similar (7.5% sirolimus vs. 5.3% CsA). More sirolimus patients received bolus steroid therapy (20 vs. 11, P = 0.068). From month 2 onward, the calculated glomerular filtration rate was consistently higher in sirolimus-treated patients. The adverse events reported more frequently with sirolimus were thrombocytopenia (45% vs. 8%) and diarrhea (38% vs. 11%). In the CsA group, increased creatinine (18% vs. 39%), hyperuricemia (3% vs. 18%), cytomegalovirus infection (5% vs. 21%), and tremor (5% vs. 21%) were observed significantly more often.Patient and graft survival and the incidence of biopsy-proven acute rejection at 12 months were comparable between sirolimus and CsA, whereas safety profiles were different. These data suggest that sirolimus may be used as primary therapy for the prevention of acute rejection.
- Published
- 2000
29. Comparison of two corticosteroid regimens in combination with CellCept and cyclosporine A for prevention of acute allograft rejection: 12 month results of a double-blind, randomized, multi-center study. M 55002 Study Group
- Author
-
Y, Lebranchu
- Subjects
Graft Rejection ,Graft Survival ,Mycophenolic Acid ,Opportunistic Infections ,Kidney Transplantation ,Survival Analysis ,Drug Administration Schedule ,Postoperative Complications ,Double-Blind Method ,Adrenal Cortex Hormones ,Bone Density ,Creatinine ,Cyclosporine ,Humans ,Drug Therapy, Combination ,Immunosuppressive Agents - Published
- 1999
30. Disposition of basiliximab, an interleukin-2 receptor monoclonal antibody, in recipients of mismatched cadaver renal allografts
- Author
-
J, Kovarik, P, Wolf, J M, Cisterne, G, Mourad, Y, Lebranchu, P, Lang, B, Bourbigot, D, Cantarovich, D, Girault, C, Gerbeau, A G, Schmidt, and J P, Soulillou
- Subjects
Adult ,Graft Rejection ,Immunosuppression Therapy ,Male ,Recombinant Fusion Proteins ,Graft Survival ,Antibodies, Monoclonal ,Receptors, Interleukin-2 ,Middle Aged ,Kidney Transplantation ,Drug Administration Schedule ,Histocompatibility ,Cadaver ,Humans ,Female ,Prospective Studies ,Immunosuppressive Agents - Abstract
Basiliximab is an interleukin-2 receptor (IL-2R; CD25) chimeric monoclonal antibody for immunoprophylaxis against acute rejection in renal transplantation. Its pharmacokinetics were characterized in a multicenter open-label, prospective dose-escalation study to identify a single-dose regimen providing IL-2R-saturating serum concentrations in the critical first posttransplant month.Thirty-two recipients of primary, mismatched cadaver kidneys were enrolled: 20 men and 12 women, who were 47+/-11 years old and weighed 65+/-12 kg. The immunosuppression regimen consisted of steroids and azathioprine from day 0 and cyclosporine from day 10. Basiliximab was infused over 30 min as a single dose preoperatively.Thirty patients were evaluable for basiliximab pharmacokinetics: 24 received 40 mg and 6 received 60 mg. Basiliximab was well tolerated without evidence of cytokine-release syndrome, hypersensitivity reactions, or anti-idiotype antibody response. Peak concentration and area under the concentration curve increased proportionally with dose. Postinfusion concentrations declined in a biphasic manner with a terminal half-life of 6.5+/-2.1 days. Weak, widely dispersed correlations were noted between body weight versus distribution volume (r=0.29) and versus clearance (r=0.45), suggesting no clinical relevance for weight-adjusted dosing. There were no apparent gender-related differences in basiliximab disposition. Previous phase II data indicated that serum concentrations in excess of 0.2 microg/ml are sufficient to saturate IL-2R epitopes on circulating T lymphocytes. Concentrations were above this threshold for 26+/-8 days (range 16 to 46) at the 40-mg dose level and for 32+/-11 days (range 22 to 51) at the 60-mg dose level.Total basiliximab doses of 40-60 mg were well tolerated, nonimmunogenic, and estimated to provide immunoprophylaxis to cover the first posttransplant month.
- Published
- 1998
31. In vitro effects of docosahexaenoic and eicosapentaenoic acids in association with cyclosporine A on human lymphocyte proliferation
- Author
-
Y. Gruel, P. Bardos, Y. Lebranchu, and B. Khalfoun
- Subjects
Interleukin 2 ,Adult ,Docosahexaenoic Acids ,medicine.medical_treatment ,Pharmacology ,Biology ,Lymphocyte Activation ,Peripheral blood mononuclear cell ,medicine ,Humans ,Lymphocytes ,Cells, Cultured ,Transplantation ,T lymphocyte ,DNA ,Ciclosporin ,Eicosapentaenoic acid ,In vitro ,Cytokine ,Eicosapentaenoic Acid ,Docosahexaenoic acid ,Immunology ,Cyclosporine ,Surgery ,medicine.drug ,Thymidine - Published
- 1997
32. Docosahexaenoic and eicosapentaenoic acids inhibit in vitro human endothelial cell production of interleukin-6
- Author
-
B, Khalfoun, F, Thibault, H, Watier, P, Bardos, and Y, Lebranchu
- Subjects
Adult ,Lipopolysaccharides ,Umbilical Veins ,Arachidonic Acid ,Docosahexaenoic Acids ,Interleukin-6 ,Tumor Necrosis Factor-alpha ,Coculture Techniques ,Kinetics ,Eicosapentaenoic Acid ,Humans ,Endothelium, Vascular ,Interleukin-4 ,Lymphocytes ,Lymphocyte Culture Test, Mixed ,Cells, Cultured - Abstract
The interaction between lymphocytes, cytokines, and endothelial cells (EC) is a key step in the inflammatory process. Interleukin-6 (IL-6) a pleiotropic cytokine in its effects, seems to be an early indicator of acute systemic inflammation. In this study, we have examined the effects of polyunsaturated fatty acids (PUFAs) on the production of IL-6 by human unstimulated EC or EC stimulated with TNF-alpha (100 U/ml); IL-4 (100 U/ml); LPS (1 ug/ml); or allogeneic peripheral blood lymphocytes (PBL). Twenty-four hour culture supernatants of immunoreactive IL-6 were measured by Sandwich ELISA. We have shown that the production of IL-6 was potentiated when EC were stimulated with TNF-alpha; IL-4; LPS; or monocyte-depleted PBL in comparison to unstimulated EC. The addition of n-3 PUFAs in culture medium (100 ug/ml DHA or EPA) significantly reduces the production of IL-6 by unstimulated EC; or stimulated with TNF-alpha; IL-4 pg/ml); LPS or depleted PBL respectively for DHA and EPA, whereas the n-6 PUFAs (Arachidonic acid), even used at the highest concentration, was ineffective. This inhibitory effect is PUFA dose dependent but is more potent with EPA than DHA. Regardless of the mode of action, since IL-6 is known to be involved in hematopoiesis, in the regulation of the immune response and in the inflammatory reaction, these results suggest that n-3 PUFAs may play a role in suppressing inflammation. Further studies are needed to elucidate the mechanism involved and the choice between the two fatty acids for clinical and therapeutic purposes.
- Published
- 1997
33. Monitoring of ATG therapy by flow cytometry and lymphocyte counts in renal transplantation
- Author
-
M, Buchler, G, Thibault, A, al Najjar, J F, Valentin, A, Guerraoui, H, Nivet, P, Bardos, and Y, Lebranchu
- Subjects
Adult ,Graft Rejection ,Time Factors ,Incidence ,Middle Aged ,Flow Cytometry ,Kidney Transplantation ,Lymphocyte Subsets ,Antigens, CD ,Humans ,Lymphocyte Count ,Drug Monitoring ,Antilymphocyte Serum ,Follow-Up Studies ,Retrospective Studies - Published
- 1996
34. Effects of docosahexaenoic and eicosapentaenoic acids on in vitro-induced human lymphoproliferative responses
- Author
-
B, Khalfoun, M, Lacord, P, Bardos, and Y, Lebranchu
- Subjects
Arachidonic Acid ,Docosahexaenoic Acids ,Eicosapentaenoic Acid ,T-Lymphocytes ,Concanavalin A ,Cyclosporine ,Humans ,Interleukin-2 ,Phytohemagglutinins ,Lymphocyte Activation ,Cells, Cultured - Published
- 1996
35. Removal of terminal alpha-galactosyl residues from xenogeneic porcine endothelial cells. Decrease in complement-mediated cytotoxicity but persistence of IgG1-mediated antibody-dependent cell-mediated cytotoxicity
- Author
-
H, Watier, J M, Guillaumin, F, Piller, M, Lacord, G, Thibault, Y, Lebranchu, M, Monsigny, and P, Bardos
- Subjects
Cytotoxicity, Immunologic ,Swine ,Antibody-Dependent Cell Cytotoxicity ,Antibodies, Monoclonal ,Galactosides ,Complement System Proteins ,Galactosidases ,Mice ,Structure-Activity Relationship ,Immunoglobulin M ,Immunoglobulin G ,Animals ,Humans ,Endothelium, Vascular ,Epitope Mapping - Abstract
To determine the role of the terminal alpha-galactosyl residue in the endothelial damage mediated by human xenoreactive natural antibodies (IgM and IgG), we treated porcine endothelial cells in culture with green coffee bean alpha-galactosidase. A practically complete removal of terminal alpha-Gal residues (as evaluated by flow cytometry with Bandeiraea simplicifolia isolectin B4) and concomitant exposure of N-acetyllactosamine were obtained without altering cell viability. A dramatic decrease in IgM and IgG binding (from a pool of human sera) was observed, confirming the key role of the alpha-galactosyl residues. The enzyme treatment did not induce any nonspecific immunoglobulin binding sites, but led to the exposure of new epitopes for a minor fraction of IgM. The main residual IgM and IgG binding could be due to xenoantigens other than the alpha-galactosyl residues. When alpha-galactosidase-treated endothelial cells were used as targets in cytotoxicity experiments, they were less susceptible than untreated cells to complement-mediated cytotoxicity induced by fresh human serum. In contrast, they did not acquire resistance to human IgG-dependent cellular cytotoxicity, despite the decrease in IgG binding. Because it is known that antibody-dependent cytotoxicity mediated by CD16+ NK cells is dependent on IgG1 and IgG3, and not on IgG2 or IgG4, which was confirmed by blocking experiments, we studied the binding of all four subclasses to intact and alpha-galactosidase-treated endothelial cells. Two major subclasses, IgG1 and IgG2, bound to untreated endothelial cells, whereas IgG3 binding was low and IgG4 binding was negligible. A decrease in IgG1, IgG2, and IgG3 binding was observed upon alpha-galactosidase treatment, indicating that antibodies belonging to these three subclasses recognize alpha-galactosyl residues. The decrease in IgG2 binding was more pronounced than the decrease in IgG1 binding. Collectively, these data indicate that IgG1 xenoreactive natural antibodies, including those which are not directed at the alpha-galactosyl residues, could play a major role in the early delayed vascular rejection of pig xenografts.
- Published
- 1996
36. Discordant xenogeneic cellular interactions when hyperacute rejection is prevented: analysis using an ex vivo model of pig kidney perfused with human lymphocytes
- Author
-
B, Khalfoun, P, Janin, M C, Machet, M, Lacord, G, Riess, H, Salmon, H, Nivet, Y, Gruel, P, Bardos, and Y, Lebranchu
- Subjects
Graft Rejection ,Perfusion ,Transplantation, Isogeneic ,Swine ,Transplantation, Heterologous ,Animals ,Humans ,Vascular Resistance ,Lymphocytes ,Kidney ,Monocytes ,Renal Circulation - Published
- 1996
37. Hodgkin's disease after transplantation
- Author
-
J L, Garnier, Y, Lebranchu, J, Dantal, J, Bedrossian, R, Cahen, D, Assouline, A, Jaccard, F, Fetissoff, A, Moreau, X, Martin, G, Delsol, F, Berger, and J L, Touraine
- Subjects
Adult ,Graft Rejection ,Male ,Herpesvirus 4, Human ,Lymphoma, B-Cell ,Adolescent ,Humans ,Pancreas Transplantation ,Middle Aged ,Hodgkin Disease ,Kidney Transplantation ,Immunosuppressive Agents - Abstract
Hodgkin's disease (HD) has seldom been reported after transplantation. Epstein-Barr virus (EBV) is present in about 50% of Reed-Sternberg cells in HD developing in immunocompetent individuals, but is more frequently found in HD of acquired immune deficiency syndrome patients. We report 7 cases of HD that occurred in transplant recipients. Clinical and pathological data and studies of EBV reveal specific features of HD after transplantation. Six patients received kidney transplants and 1 patient received combined kidney and pancreas transplantation. Immunosuppressive therapy consisted of cyclosporine, steroids, azathioprine, and antilymphocyte globulins. One patient received, in addition, anti-CD3 mAb therapy and an EBV+ B cell lymphoma developed. Retrospective EBV serological data from patients were collected. Tumors were classified according to pathology. EBV studies were conducted by immunohistochemical methods with monoclonal antibodies to EBV-latent membrane protein (LMP) or EBV-nuclear antigen 2 (EBNA2), and by in situ hybridization for latent nuclear EBV-early RNAs (EBERs). The mean lapse of time between transplantation and HD was 49 months. Six patients presented with enlarged lymph nodes and 1 patient presented with liver involvement. HD was classified as IA in 2 patients, IIA in 3 patients, IIIB in 1 patient, and IVB in 1 patient. Four patients had primary EBV infection after graft, before HD, and the others reactivated latent EBV infection. Histological subtypes were mixed cellularity in 6 cases and lymphocytic depletion in 1 case. Latent EBV infection was detected with EBERs in all tumors. Reed-Sternberg cells expressed LMP, and were negative for EBNA2 expression. Six patients were treated: 2 patients at stage I received radiotherapy, and relapsed within 1 year with a more advanced stage of HD; chemotherapy was indicated as primary therapy in 5 patients, and as salvage therapy in 2 patients; it was associated with radiotherapy in 4 patients. Immunosuppressive therapy was reduced in all patients. Four patients were alive and in complete remission 18, 25, 31, and 67 months after chemotherapy, with a functioning graft in 3 patients. Two patients died of infection. Mixed cellularity is the most frequent histological subtype observed in HD occurring in transplant patients. EBV is present in all Reed-Sternberg cells. Posttransplant HD shows similarities with human immunodeficiency virus-associated HD. These facts argue for a role of EBV infection and immunosuppression in the progression of HD after transplantation.
- Published
- 1996
38. Le syndrome hyperIgE et infections récidivantes ou syndrome de Buckley : deux cas cliniques et évolution à long terme
- Author
-
Gérard Lorette, Laurent Machet, A. Bernez, M. Piram, and Y. Lebranchu
- Subjects
Dermatology - Published
- 2004
39. Posttransplant anti-HLA antibodies: risk factor for chronic rejection?
- Author
-
M, Buchler, A, al Najjar, A, Guerraoui, J F, Valentin, M D, Boulanger, R, Sherobeen, A, Lataste, H, Nivet, and Y, Lebranchu
- Subjects
Cytotoxicity, Immunologic ,Graft Rejection ,Chi-Square Distribution ,Time Factors ,HLA Antigens ,Risk Factors ,Creatinine ,Antibody Formation ,Humans ,Kidney Transplantation ,Retrospective Studies - Published
- 1995
40. Anti-HLA antibodies increase lymphocyte adhesion to allogeneic endothelium
- Author
-
M, Buchler, A, al Najjar, B, Khalfoun, Y, Gruel, H, Nivet, P, Bardos, and Y, Lebranchu
- Subjects
Umbilical Veins ,HLA Antigens ,Reference Values ,Cell Adhesion ,Humans ,Immunization ,Endothelium, Vascular ,Lymphocytes ,Cells, Cultured ,Autoantibodies - Published
- 1995
41. Hodgkin's disease after renal transplantation
- Author
-
J L, Garnier, Y, Lebranchu, N, Lefrançois, X, Martin, J M, Dubernard, F, Berger, and J L, Touraine
- Subjects
Adult ,Male ,Herpesvirus 4, Human ,Time Factors ,Adolescent ,Herpesviridae Infections ,Hodgkin Disease ,Kidney Transplantation ,Tumor Virus Infections ,Postoperative Complications ,Humans ,Reed-Sternberg Cells ,Follow-Up Studies ,Neoplasm Staging - Published
- 1995
42. The association of increased soluble VCAM-1 levels with CMV disease in human kidney allograft recipients
- Author
-
Y, Lebranchu, A, al Najjar, P, Kapahi, J F, Valentin, H, Nivet, P, Bagros, P, Bardos, and D, Haskard
- Subjects
Postoperative Complications ,Cytomegalovirus Infections ,Humans ,Transplantation, Homologous ,Vascular Cell Adhesion Molecule-1 ,Drug Therapy, Combination ,Enzyme-Linked Immunosorbent Assay ,Cell Adhesion Molecules ,Kidney Transplantation ,Biomarkers ,Immunosuppressive Agents - Published
- 1995
43. Organ procurement from cadaveric children
- Author
-
Y. Lebranchu, Georges Deschênes, H. Nivet, C. H. Cheliakine, and S. Benoit
- Subjects
Pediatric intensive care unit ,medicine.medical_specialty ,Organ procurement ,business.industry ,Intensive care ,Medicine ,Medical team ,Cadaveric spasm ,business ,Intensive care medicine ,Organ transplantation ,Harvesting organs - Abstract
Remarkable progress in organ transplantation has led to a dramatic rise in the demand for organs both in adults and children. All pediatric intensive care units (PICUs) are involved in harvesting organs, nevertheless, organs are collected from a limited number of potential donors. This situation is more a problem of organisation, willingness and ethics than one of techniques.
- Published
- 1995
44. Soluble e-selectin, ICAM-1, and VCAM-1 levels in renal allograft recipients
- Author
-
Y, Lebranchu, P, Kapahi, A, al Najjar, R, Sharobeem, J F, Valentin, H, Nivet, P, Bagros, and D, Haskard
- Subjects
Graft Rejection ,Antigens, CD ,Reference Values ,Graft Survival ,Humans ,Transplantation, Homologous ,Vascular Cell Adhesion Molecule-1 ,E-Selectin ,Intercellular Adhesion Molecule-1 ,Cell Adhesion Molecules ,Kidney Transplantation ,Biomarkers - Published
- 1994
45. IL-4, but not tumor necrosis factor-alpha, increases endothelial cell adhesiveness for lymphocytes by activating a cAMP-dependent pathway
- Author
-
P, Galéa, G, Thibault, M, Lacord, P, Bardos, and Y, Lebranchu
- Subjects
Tumor Necrosis Factor-alpha ,Cell Adhesion ,Cyclic AMP ,Humans ,Vascular Cell Adhesion Molecule-1 ,Endothelium, Vascular ,Interleukin-4 ,Lymphocytes ,Intercellular Adhesion Molecule-1 ,Cell Adhesion Molecules ,Cells, Cultured - Abstract
IL-4 and TNF-alpha increase endothelial cell adhesiveness for PBL by promoting the expression of adhesion molecules. We investigated the intracellular cAMP involvement in the increased endothelial cell adhesivity induced by IL-4 or TNF-alpha. We showed that both IL-4 and TNF-alpha increased intracellular cAMP in endothelial cells (EC). Furthermore, dibutyryl-cAMP and forskolin (which increased intracellular cAMP) increased basic EC adhesivity for PBL. The co-stimulation of EC with cAMP elevating agents and TNF-alpha, but not IL-4, resulted in an additive increase in EC adhesiveness. 2',5' dideoxyadenosine, an inhibitor of adenylate cyclase, decreased PBL adhesion to IL-4- but not TNF-alpha-treated EC. Similarly, HA1004, a protein kinase A inhibitor, totally reversed the IL-4 but not TNF-alpha effect on EC adhesiveness, whereas H7, a protein kinase C inhibitor, did not antagonise cytokine-enhanced EC adhesivity. These results indicate that IL-4, but not TNF-alpha, uses a cAMP-dependent pathway to increase PBL adhesion. Furthermore, we showed that cAMP elevation in EC did not induce vascular cell adhesion molecule 1, the only identified adhesion molecule induced by IL-4, indicating that a rise in cAMP in EC promotes an as yet unidentified adhesion pathway. Our results show that IL-4 increases EC adhesiveness for PBL through activation of protein kinase A by promoting an unidentified adhesion pathway.
- Published
- 1993
46. Lymphocyte adhesion to allogeneic endothelium involves at least four different pathways
- Author
-
P, Galea, J F, Valentin, and Y, Lebranchu
- Subjects
Graft Rejection ,Kinetics ,Tumor Necrosis Factor-alpha ,Cell Adhesion ,Animals ,Antibodies, Monoclonal ,Humans ,Endothelium, Vascular ,Interleukin-4 ,Lymphocytes ,Cell Adhesion Molecules - Published
- 1993
47. IMPACT OF EARLY CONVERSION AT 3 MONTHS FROM CYCLOSPORINE ( CSA) TO SIROLIMUS ( SRL) IN ASSOCIATION WITH MYCOPHENOLATE MOFETIL ( MMF) ON RENAL FUNCTION
- Author
-
L. Saada and Y. Lebranchu
- Subjects
Transplantation ,medicine.medical_specialty ,business.industry ,Sirolimus ,medicine ,Urology ,Renal function ,business ,Mycophenolate ,medicine.drug - Published
- 2010
48. Deficiency of CD4+CD45RA+ lymphocytes in patients with glioblastoma multiforme
- Author
-
P, Ménage, G, Thibault, Y, Lebranchu, M, Jan, and P, Bardos
- Subjects
Adult ,CD4-Positive T-Lymphocytes ,Male ,Brain Neoplasms ,Integrin beta1 ,CD4-CD8 Ratio ,Immunologic Deficiency Syndromes ,Middle Aged ,Leukocyte Count ,Antigens, CD ,T-Lymphocyte Subsets ,Humans ,Leukocyte Common Antigens ,Female ,Glioblastoma - Published
- 1992
49. Lymphocyte subsets in renal transplant recipients treated with mycophenolate mofetil
- Author
-
G Thibault, M. Büchler, Y Lebranchu, A. Al-Najjar, Jean-Michel Halimi, Maud François, and J.F. Valentin
- Subjects
Adult ,Graft Rejection ,Male ,Cellular immunity ,medicine.medical_specialty ,medicine.medical_treatment ,Lymphocyte ,Urinary system ,Mycophenolate ,Gastroenterology ,Mycophenolic acid ,Internal medicine ,medicine ,Humans ,Antilymphocyte Serum ,Retrospective Studies ,Transplantation ,Kidney ,Chemotherapy ,business.industry ,Mycophenolic Acid ,Flow Cytometry ,Kidney Transplantation ,Lymphocyte Subsets ,medicine.anatomical_structure ,Immunology ,Cyclosporine ,Drug Therapy, Combination ,Female ,Surgery ,business ,Immunosuppressive Agents ,medicine.drug - Published
- 2000
50. Endothelial cells provide costimulatory signals to trigger both allogeneic adult and cord blood (NAIVE) CD4+ T-Cell proliferation
- Author
-
S. Cappellesso, Y Lebranchu, H. Watier, and N. O.S Camara
- Subjects
Adult ,CD4-Positive T-Lymphocytes ,Isoantigens ,Umbilical Veins ,Transplantation ,Cell growth ,T cell ,Infant, Newborn ,T lymphocyte ,Biology ,Fetal Blood ,Lymphocyte Activation ,Umbilical cord ,Endothelial stem cell ,medicine.anatomical_structure ,Cell–cell interaction ,Cell culture ,Cord blood ,Immunology ,medicine ,Humans ,Surgery ,Endothelium, Vascular ,Phytohemagglutinins ,Cells, Cultured - Published
- 2000
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