1. High Asymptomatic Carriage With the Omicron Variant in South Africa
- Author
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Garrett, Nigel, Tapley, Asa, Andriesen, Jessica, Seocharan, Ishen, Fisher, Leigh H, Bunts, Lisa, Espy, Nicole, Wallis, Carole L, Randhawa, April Kaur, Miner, Maurine D, Ketter, Nzeera, Yacovone, Margaret, Goga, Ameena, Huang, Yunda, Hural, John, Kotze, Philip, Bekker, Linda Gail, Gray, Glenda E, Corey, Lawrence, and Ubuntu Study Team
- Subjects
SARS-CoV-2 ,Prevention ,Clinical Trials and Supportive Activities ,COVID-19 ,Omicron variant ,Pneumonia ,Biological Sciences ,Polymerase Chain Reaction ,Medical and Health Sciences ,Microbiology ,asymptomatic carriage ,Vaccine Related ,South Africa ,Ubuntu Study Team ,Infectious Diseases ,Emerging Infectious Diseases ,Good Health and Well Being ,Clinical Research ,Biodefense ,Pneumonia & Influenza ,Humans ,PWH ,Infection ,Lung - Abstract
We report a 23% asymptomatic severe acute respiratory syndrome coronavirus 2 (SARS CoV-2) Omicron carriage rate in participants being enrolled into a clinical trial in South Africa, 15-fold higher than in trials before Omicron. We also found lower CD4 + T-cell counts in persons with human immunodeficiency virus (HIV) strongly correlated with increased odds of being SARS-CoV-2 polymerase chain reaction (PCR) positive.
- Published
- 2022