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1. [Guidelines on the management of valvular heart disease (version 2012). The Joint Task Force on the Management of Valvular Heart Disease of the European Society of Cardiology (ESC) and the European Association for Cardio-Thoracic Surgery (EACTS)]. FT Linee guida per il trattamento delle valvulopatie (versione 2012). Task Force congiunta per il Trattamento delle Valvulopatie della Societa Europea di Cardiologia (ESC) e dell'Associazione Europea di Chirurgia Cardiotoracica (EACTS)

Author

Vahanian, A, ALFIERI, OTTAVIO, Andreotti, F, Antunes, Mj, Baron esquivias, G, Baumgartner, H, Nulla, Nullborger Michael, Carrel, Tp, DE BONIS , MICHELE, Evangelista, A, Falk, V, Iung, B, Lancellotti, P, Pierard, L, Price, S, Schafers, Hj, Schuler, G, Stepinska, J, Swedberg, K, Takkenberg, J, Von Oppell Uo, Windecker, S, Zamorano, Jl, Zembala, M., Vahanian, A, Alfieri, Ottavio, Andreotti, F, Antunes, Mj, Baron esquivias, G, Baumgartner, H, Nulla, Nullborger Michael, Carrel, Tp, DE BONIS, Michele, Evangelista, A, Falk, V, Iung, B, Lancellotti, P, Pierard, L, Price, S, Schafers, Hj, Schuler, G, Stepinska, J, Swedberg, K, Takkenberg, J, Von Oppell, Uo, Windecker, S, Zamorano, Jl, and Zembala, M.

Published
2013

2. Guidelines on myocardial revascularization

Author

Task Force on Myocardial Revascularization of the European Society of Cardiology, the European Association for Cardio Thoracic Surgery, European Association for Percutaneous Cardiovascular Interventions, Wijns W, Kolh P, Danchin N, Di Mario C, Falk V, Folliguet T, Garg S, Huber K, James S, Knuuti J, Lopez Sendon J, Marco J, Menicanti L, Ostojic M, Piepoli MF, Pirlet C, Pomar JL, Reifart N, Ribichini FL, Schalij MJ, Sergeant P, Serruys PW, Silber S, Sousa Uva M, Taggart D. Collaborators: Vahanian A, Auricchio A, Bax J, Ceconi C, Dean V, Filippatos G, Funck Bretano C, Hobbs R, Kearney P, McDonagh T, Popescu BA, Reiner Z, Sechtem U, Sirnes PA, Tendera M, Vardas PE, Widimsky P, Dunning J, Elia S, Kappetein P, Lockowandt U, Sarris G, Vouohe P, von Segesser L, Agewall S, Aladashvili A, Alexopoulos D, Antunes MJ, Atalar E, de la Riviere AB, Doganov A, Eha J, Fajadet J, Ferreira R, Garot J, Halcox J, Hasin Y, Janssens S, Kervinen K, Laufer G, Legrand V, Nashef SA, Neumann FJ, Niemela K, Nihoyannopoulos P, Noc M, Piek JJ, Pirk J, Rozenman Y, Sabate M, Starc R, Thielmann M, Wheatley DJ, Windecker S, Zembala M., ALFIERI , OTTAVIO, ACS - Amsterdam Cardiovascular Sciences, Cardiology, Task Force on Myocardial Revascularization of the European Society of, Cardiology, the European Association for Cardio Thoracic, Surgery, European Association for Percutaneous Cardiovascular, Intervention, Kolh, P, Wijns, W, Danchin, N, Di Mario, C, Falk, V, Folliguet, T, Garg, S, Huber, K, James, S, Knuuti, J, Lopez Sendon, J, Marco, J, Menicanti, L, Ostojic, M, Piepoli, Mf, Pirlet, C, Pomar, Jl, Reifart, N, Ribichini, Fl, Schalij, Mj, Sergeant, P, Serruys, Pw, Silber, S, Sousa Uva, M, Taggart D., Collaborators: Vahanian A, Auricchio, A, Bax, J, Ceconi, C, Dean, V, Filippatos, G, Funck Brentano, C, Hobbs, R, Kearney, P, Mcdonagh, T, Popescu, Ba, Reiner, Z, Sechtem, U, Sirnes, Pa, Tendera, M, Vardas, Pe, Widimsky, P, Alfieri, Ottavio, Dunning, J, Elia, S, Kappetein, P, Lockowandt, U, Sarris, G, Vouhe, P, von Segesser, L, Agewall, S, Aladashvili, A, Alexopoulos, D, Antunes, Mj, Atalar, E, de la Riviere, Ab, Doganov, A, Eha, J, Fajadet, J, Ferreira, R, Garot, J, Halcox, J, Hasin, Y, Janssens, S, Kervinen, K, Laufer, G, Legrand, V, Nashef, Sa, Neumann, Fj, Niemela, K, Nihoyannopoulos, P, Noc, M, Piek, Jj, Pirk, J, Rozenman, Y, Sabate, M, Starc, R, Thielmann, M, Wheatley, Dj, Windecker, S, Zembala, M., Funck Bretano, C, and Vouohe, P

Subjects
Carotid Artery Diseases, Graft Rejection, lcsh:Diseases of the circulatory (Cardiovascular) system, Judgement, Settore MED/21 - Chirurgia Toracica, Medizin, Heart Valve Diseases, Myocardial Ischemia, Contrast Media, Myocardial Revascularization, Assisted Circulation, General Environmental Science, Drug-Eluting Stents, General Medicine, Prognosis, Europe, Stroke, Acute Disease, Cardiology, Platelet aggregation inhibitor, Kidney Diseases, Medical emergency, Cardiology and Cardiovascular Medicine, Risk assessment, Pulmonary and Respiratory Medicine, Diagnostic Imaging, medicine.medical_specialty, Myocardial revascularization, MEDLINE, Renal Artery Obstruction, Risk Assessment, End stage renal disease, Blood Vessel Prosthesis Implantation, Fibrinolytic Agents, Patient Education as Topic, Internal medicine, Preoperative Care, medicine, Humans, Hypoglycemic Agents, Heart Failure, Postoperative Care, business.industry, Contraindications, Conflict of interest, Arrhythmias, Cardiac, Evidence-based medicine, medicine.disease, lcsh:RC666-701, Chronic Disease, General Earth and Planetary Sciences, Surgery, business, Fibrinolytic agent, Diabetic Angiopathies, Platelet Aggregation Inhibitors
Abstract

Guidelines and Expert Consensus Documents summarize and evaluate all available evidence with the aim of assisting physicians in selecting the best management strategy for an individual patient suffering from a given condition, taking into account the impact on outcome and the risk benefit ratio of diagnostic or therapeutic means. Guidelines are no substitutes for textbooks and their legal implications have been discussed previously. Guidelines and recommendations should help physicians to make decisions in their daily practice. However, the ultimate judgement regarding the care of an individual patient must be made by his/her responsible physician(s). The recommendations for formulating and issuing ESC Guidelines and Expert Consensus Documents can be found on the ESC website (http://www.escardio.org/knowledge/ guidelines/rules). Members of this Task Force were selected by the European Society of Cardiology (ESC) and the European Association for Cardio-Thoracic Surgery (EACTS) to represent all physicians involved with the medical and surgical care of patients with coronary artery disease (CAD). A critical evaluation of diagnostic and therapeutic procedures is performed including assessment of the risk benefit ratio. Estimates of expected health outcomes for society are included, where data exist. The level of evidence and the strength of recommendation of particular treatment options are weighed and graded according to predefined scales, as outlined in Tables 1 and 2. The members of the Task Force have provided disclosure statements of all relationships that might be perceived as real or potential sources of conflicts of interest. These disclosure forms are kept on file at European Heart House, headquarters of the ESC. Any changes in conflict of interest that arose during the writing period were notified to the ESC. The Task Force report received its entire financial support from the ESC and EACTS, without any involvement of the pharmaceutical, device, or surgical industry. ESC and EACTS Committees for Practice Guidelines are responsible for the endorsement process of these joint Guidelines. The finalized document has been approved by all the experts involved in the Task Force, and was submitted to outside specialists selected by both societies for review. The document is revised, and finally approved by ESC and EACTS and subsequently published simultaneously in the European Heart Journal and the European Journal of Cardio-Thoracic Surgery. After publication, dissemination of the Guidelines is of paramount importance. Pocket-sized versions and personal digital assistant-downloadable versions are useful at the point of care. Some surveys have shown that the intended users are sometimes unaware of the existence of guidelines, or simply do not translate them into practice. Thus, implementation programmes are needed because it has been shown that the outcome of disease may be favourably influenced by the thorough application of clinical recommendations.

Published
2010

3. Local low-doxe IL-2 therapy

Author

Otter, W. Den, Balemans, L., Battermann, J. J., Monique Bernsen, Cadee, J. A., Dobrowolski, Z., Everse, L. A., Fiszer-Maliszewska, L., Gavhumende, R., Groot, J. W., Groot, K., Hennin, W. E., Hill, F. W., Jurgenliemp-Schulz, I. M., Klein, W. R., Koten, J. W., Maas, R. A., Steerenberg, P. A., Stewart, R., and Zembala, M.

Subjects
Molecular pathological analysis of regressing melanocytic lesions at the single cell level using a laser dissection microscope, Moleculair pathologische analyse van regressie van melanocytaire lesies met behulp van een laser dissectie microscoop
Abstract

Item does not contain fulltext

Published
1999

4. Coronary-artery bypass surgery in patients with left ventricular dysfunction

Author

Velazquez, E, Lee, K, Deja, Ma:, J, A, Sopko, G, Marchenko, A, Ali, I, Pohost, G, Gradinac, S, Abraham, W, Yii, M, Prabhakaran, D, Szwed, H, Ferrazzi, P, Petrie, M, O'Connor, C, Panchavinnin, P, She, L, Bonow, R, Rankin, G, Jones, R, Rouleau, J, Cherniavsky, A, Romanov, A, Wos, S, Deja, M, Golba, K, Malinowski, M, Kosevic, D, Vukovic, M, Djokovic, L, Krzeminska Pakula, M, Jaszewski, R, Drozdz, J, Chrzanowski, L, Rajda, M, Howlett, J, Macfarlane, M, Jain, A, Shah, H, Rakshak, D, Saxena, A, Zembala, M, Przybylski, R, Kukulski, T, Wasilewski, J, Wiechowski, S, Brykczynski, M, Kurowski, M, Mokrzycki, K, Sadowski, J, Kapelak, B, Sobczyk, D, Plicner, D, Wrobel, K, Piegas, L, Paulista, P, Farsky, P, Veiga Kantorowitz, C, Sadowski, Z, Juraszynski, Z, Dabrowski, R, Rogowski, J, Pawlaczyk, R, Rynkiewicz, A, Betlejewski, P, Siepe, M, Geibel Zehender, A, Cuerten, C, Higgins, R, Crestanello, J, Binkley, P, Jones, D, Sun, B, Smith, P, Milano, C, Adams, P, Hill, J, Beaver, T, Leach, D, Airan, B, Das, S, Prior, D, Mack, J, Rao, V, Iwanochko, R, Renton, J, Phuangkaew, N, Bochenek, A, Krejca, M, Trusz Gluza, M, Wita, K, Gavazzi, A, Senni, M, Natarajan, S, Padmanabhan, C, Racine, N, Bouchard, D, Ducharme, A, Brown, H, Alotti, N, Lupkovics, G, Kumar, S, Agarwal, S, Sinha, N, Rai, H, Andersson, B, Janssen, A, Lamy, A, Demers, C, Rizzo, T, Doenst, T, Garbade, J, Thiele, H, Richter, M, Murday, A, Shaw, M, Raju, K, Mannam, G, Reddy, G, Rao, K, Nicolau, J, Stolf, N, Vieira, A, Chua, Y, Lim, C, Kwok, B, Gan, Y, Cleland, J, Cale, A, Thackray, S, Lammiman, M, Michler, R, Swayze, R, Maurer, G, Grimm, M, Lang, I, Adlbrecht, C, Daly, R, Rodeheffer, R, Nelson, S, Larbalestier, R, Wang, X, Haddad, H, Hendry, P, Donaldson, J, Menicanti, L, Di Donato, M, Castelvecchio, S, Sirvydis, V, Voluckiene, E, Di Benedetto, G, Attisano, T, Favaloro, R, Favaloro, L, Diez, M, Riccitelli, M, Picone, V, Koslowski, P, Gaito, M, Al mohammad, A, Braidley, P, Steele, H, Nawarawong, W, Woragidpoonpol, S, Kuanprasert, S, Mekara, W, Kon, N, Hammon, J, Wells, G, Tilley, W, Drazner, M, Di Maio, M, Peschka, S, Pasquale, D, Knight, C, J, Aylward, P, Thomas, C, Gullestad, L, Sorensen, G, Kaul, U, Gupta, R, Schmedtje, Jj, Arnold, S, Wilson, V, Grayburn, P, Hamman, B, Hebeler, R, Aston, S, Birjiniuk, V, Harrington, M, Dupree, C, Sheridan, B, Schuler, C, Helou, J, Denis, I, Bigalli, D, Gutierrez, F, Russo, N, Batlle, C, White, H, Alison, P, Stewart, R, Borthwick, L, Philippides, G, Shemin, R, Fitzgerald, C, Dagenais, F, Dussault, G, Kamath, P, Busmann, C, Ferrari, G, Botto, M, Horkay, F, Hartyanszky, I, Bartha, E, Simor, T, Papp, L, Toth, L, Varga Szemes, A, Szekely, L, Keltai, M, Edes, I, Szathmarine, V, Yakub, M, Sarip, S, Maitland, A, Isaac, D, Holland, M, Bogats, G, Csepregi, L, Maia, L, Soares, M, Mouco, O, Souza, A, da Rocha, A, Brito, J, Pitella, F, Camara, A, Horowitz, J, Knight, J, Rose, J, Mcrae, Rj, Geiss, D, Clemson, B, Pierson, M, Kron, I, Kern, J, Bergin, J, Phillips, J, Rich, J, Herre, J, Pine, L, Chin, D, Spyt, T, Logtens, E, Amuchastegui, L, Bracco, D, Ruengsakulrach, P, Pitiguagool, V, Sukhum, P, Srinualta, D, Hayward, C, Herrera, C, Zimmermann, R, Patterson, G, Stephens, W, Dignan, R, French, J, Sequalino, N, Vaishnav, S, Panda, R, Chavan, A, Benetis, R, Jankauskiene, L, Kalil, R, Nesralla, I, Santos, M, de Moraes, M, Friedrich, I, Buerke, M, Paraforos, A, Konda, S, Leone, C, Murphy, E, Ravichandran, P, Avalos, K, Hetzer, R, Knosalla, C, Hoffmann, K, Landolfo, K, Landolfo, C, Park, M, Chiariello, L, Nardi, P, Stapleton, D, Hoey, K, Hasaniya, N, Wang, N, Bijou, R, Naka, Y, Ascheim, D, Mikati, I, Arnold, M, Mckenzie, N, Smith, J, Gheorghiade, M, Fullerton, D, Roberts, L, Carson, P, Miller, A, Pina, I, Selzman, C, Wertheimer, J, Goldstein, S, Cohn, F, Hlatky, M, Kennedy, K, Rankin, S, Robbins, R, Zaret, B, Barfield, T, Desvigne Nickens, P, Oh, J, Panza, J, Apte, P, Doyle, M, Forder, J, Ocon, M, Pai, R, Reddy, V, Santos, N, Tripathi, R, Varadarajan, P, Pellikka, P, Miller, Fj, Lin, G, Borgeson, D, Ommen, S, Casaclang Verzosa, G, Miller, D, Springer, R, Blahnik, F, Manahan, B, Welper, J, Wiste, H, Mark, D, Anstrom, K, Baloch, K, Burnette, A, Cowper, P, Davidson Ray, N, Drew, L, Harding, T, Hunt, V, Knight, D, Patterson, A, Redick, T, Sanderford, B, Feldman, A, Bristow, M, Chan, T, Maisel, A, Mann, D, Mcnamara, D, Holly, T, Berman, D, Leonard, S, Helmer, D, Woods, M, Mcnulty, M, Asch, F, Rumsey, M, Bieganski, S, Roberts, B, Handschumacher, M, Mccormick, A, Albright, J, Dandridge, R, Rittenhouse, L, Wagstaff, D, Williams, M, Bailey, D, Glover, D, Parrish, L, Wakeley, N, Jackson, V, Nicholson, B, Mcdaniel, A, Al Khalidi, H, Greene, D, and Moore, V

Subjects
Male, medicine.medical_specialty, Coronary Artery Disease, Kaplan-Meier Estimate, 030204 cardiovascular system & hematology, law.invention, Coronary artery disease, 03 medical and health sciences, Coronary artery bypass surgery, Ventricular Dysfunction, Left, 0302 clinical medicine, Randomized controlled trial, law, Internal medicine, medicine, Clinical endpoint, Humans, 03.02. Klinikai orvostan, cardiovascular diseases, 030212 general & internal medicine, Coronary Artery Bypass, Aged, Proportional Hazards Models, Heart Failure, Intention-to-treat analysis, Proportional hazards model, business.industry, Hazard ratio, Settore MED/23 - Chirurgia Cardiaca, General Medicine, Middle Aged, medicine.disease, Combined Modality Therapy, 3. Good health, Surgery, Intention to Treat Analysis, Hospitalization, surgical procedures, operative, Cardiovascular Diseases, Heart failure, Cardiology, Female, business
Abstract

The role of coronary-artery bypass grafting (CABG) in the treatment of patients with coronary artery disease and heart failure has not been clearly established.Between July 2002 and May 2007, a total of 1212 patients with an ejection fraction of 35% or less and coronary artery disease amenable to CABG were randomly assigned to medical therapy alone (602 patients) or medical therapy plus CABG (610 patients). The primary outcome was the rate of death from any cause. Major secondary outcomes included the rates of death from cardiovascular causes and of death from any cause or hospitalization for cardiovascular causes.The primary outcome occurred in 244 patients (41%) in the medical-therapy group and 218 (36%) in the CABG group (hazard ratio with CABG, 0.86; 95% confidence interval [CI], 0.72 to 1.04; P=0.12). A total of 201 patients (33%) in the medical-therapy group and 168 (28%) in the CABG group died from an adjudicated cardiovascular cause (hazard ratio with CABG, 0.81; 95% CI, 0.66 to 1.00; P=0.05). Death from any cause or hospitalization for cardiovascular causes occurred in 411 patients (68%) in the medical-therapy group and 351 (58%) in the CABG group (hazard ratio with CABG, 0.74; 95% CI, 0.64 to 0.85; P

Published
2011

5. Apoptosis of human monocytes/macrophages in mycobacterium tuberculosis infection

Author

PLACIDO R., MANCINO G., AMENDOLA A., MARIANI F., VENDETTI S., PIACENTINI M., ZEMBALA M., SANDUZZI ZAMPARELLI, ALESSANDRO, BOCCHINO, MARIALUISA, Placido, R., Mancino, G., Amendola, A., Mariani, F., Vendetti, S., Piacentini, M., SANDUZZI ZAMPARELLI, Alessandro, Bocchino, Marialuisa, and Zembala, M.

Published
1997

6. Improved biocompatibility of extracorporeal circulation by the use of auto-oxygenation instead of artificial oxygenator in perfusion circuit

Author

Andrzej Bochenek, Religa Z, Kustosz R, Am, Wnuk-Wojnar, Wnuk R, Wojnar J, Woś S, Wites M, Zembala M, and Spyt T

Subjects
Blood Platelets, Extracorporeal Circulation, Hemoglobins, Leukocyte Count, Bleeding Time, Cardiopulmonary Bypass, Platelet Count, Materials Testing, Humans, Biocompatible Materials, Middle Aged, Oxygenators, Complement Activation
Abstract

The aim of this study was to determine the biocompatibility of an auto-oxygenation technique of cardiopulmonary bypass. Forty patients undergoing coronary bypass surgery were studied in two groups: A (auto-oxygenation, patients' lungs used in cardiopulmonary bypass) and B (conventional technique of cardiopulmonary bypass with bubble oxygenator). The platelet count decreased to -73% of initial value in group B vs only -27% in group A, P less than 0.001. Platelet aggregation to ADP decreased slightly in group A and hardly at all in group B, P less than 0.001. A transpulmonary leukocyte sequestration was greater in group B: 1.46 +/- 0.5 x 10(3)/mm3 vs only 0.34 +/- 0.2 x 10(3)/mm3 in group A, P less than 0.001. The level of C3a increased in group A from 244 +/- 46 ng/ml to 418 +/- 34 ng/ml and in group B from 268 +/- 46 ng/ml to 521 +/- 65 ng/ml, P less than 0.001, but in group A the levels were significantly less, P less than 0.001. The current study clearly confirms the superior biocompatibility of cardiopulmonary bypass with lung over oxygenator.

Published
1991

7. [Surgical treatment of paroxysmal ventricular tachycardia (personal observations)]

Author

Zembala M, Religa Z, Andrzej Bochenek, Buszman P, Trusz-Gluza M, Wnuk-Wojnar A, Pasyk S, Giec L, Moll J, and Woś S

Subjects
Male, Humans, Female, Middle Aged, Tachycardia, Paroxysmal, Aged
Abstract

Five patients with recurrent VT/VF resistant to medical treatment were successfully treated surgically. In 3 patients excision of the altered endocardium by Harken's method (endocardial peeling) was done; in 2 of the patients it was preceded by intraoperative electrophysiological study. Two other patients were treated alternatively: a 45-year old patients with post-MI cardiomyopathy had a cardiac transplantation and a 57-year old patient with good left ventricular function an implantation of a automatic cardioverter-defibrillator (AICD). No patient had VT and/or VF during the 14-35 month follow-up. Exercise tolerance improved in all patients. Good short- and longterm results of surgical treatment show that these methods can be effective in treating patients with life-threatening arrhythmias resistant to pharmacological therapy.

Published
1990

12. Good long-term result of biventricular assisted circulation using POLCAS-RELIGA system in 16-year old boy with a irreversible heart failure - A case report,Dobry długoterminowy efekt zastosowania wspomagania dwukomorowego serca BIVAD za pomoca systemu POLCAS-RELIGA u 16-letniego chorego z ciecżkim nieodwracalnym uszkodzeniem serca - Opis przypadku

Author

Pacholewicz, J., Tomasz Hrapkowicz, Chodor, B., Kubacki, K., Kucewicz, E., Nadziakiewicz, P., Borowicz, M., Tylińska, D., Sioła, M., Bauer, A., Jaworska, I., Zakliczyński, M., Białkowski, J., Kustosz, R., Zembala, M., and Religa, Z.

22. [Cardiogenic shock. Surgical reperfusion and myocardial revascularization]

Author

Zembala M, Religa Z, Kucewicz E, Andrzej Bochenek, Wojtalik M, Moll J, Glanc W, Puzio J, Czech B, and Cichoń R

Subjects
Death, Sudden, Intraoperative Care, Postoperative Complications, Time Factors, Heart Arrest, Induced, Myocardial Infarction, Shock, Cardiogenic, Humans, Myocardial Reperfusion, Coronary Artery Bypass, Emergencies, Middle Aged, Aged
Abstract

Emergency coronary bypass for cardiogenic shock has been associated with a high operative mortality. From February 1986 through October 1989, 40 patients with acute myocardial infarction were operated. Ten pts (25%) were in shock despite intensive treatment (intra-aortic balloon pump in 4, catecholamines in 10). Seven pts. required cardiopulmonary resuscitation before operations. After operations 66% of the patients required catecholamine support and 60% were treated with intra-aortic balloon pump. There were three (30%) hospital deaths (one in the operating room due to acute cardiac failure). Follow-up (100%),(mean 26 months) revealed one late death--39 months after operations. In functional class I were 2 patients, II--one, and III--two pts. One pt is in group IV (transplant candidate). Myocardial infarction complicated by cardiogenic shock can produce a mortality rate in excess of 85%. Contemporary medical management has had little effect on mortality, hence effective surgical therapy has evolved for this lesion.

25. Electrophysiologic properties of transplanted human heart with and without rejection

Author

Am, Wnuk-Wojnar, Zembala M, Religa Z, Andrzej Bochenek, Jaklik A, Drzewiecki J, and Giec L

Subjects
Graft Rejection, Male, Electrocardiography, Pacemaker, Artificial, Refractory Period, Electrophysiological, Heart Conduction System, Biopsy, Myocardium, Cardiac Pacing, Artificial, Heart Transplantation, Humans, Arrhythmias, Cardiac, Middle Aged
Abstract

Twelve male heart transplant recipients underwent routine electrophysiologic evaluation. None were taking cardioactive drugs, and only two had symptoms of arrhythmia. Two patients had endocardial VVI pacemakers because of previous early sinus node dysfunction. With simultaneous endomyocardial biopsy, we found seven patients with no evidence of rejection (group 1) and five patients with mild rejection (group 2; three initial or mild; two definite rejection). In two group 1 patients with presyncope, corrected sinus node recovery time was prolonged, and pacemakers were implanted into the endocardium. In all patients atrioventricular conduction was normal. One patient had evidence of functional duality of anterograde atrioventricular nodal conduction. In group 2 patients prolongation of effective refractory period of the donor atrium, functional refractory period of the atrioventricular node, and effective refractory period of the right ventricle were observed. This prolongation of refractoriness may be one of the earliest markers of rejection.

30. Guidelines on the management of valvular heart disease (version 2012): the Joint Task Force on the Management of Valvular Heart Disease of the

Author

AuthorsTask Force Members, Vahanian, A., Alfieri, O., Andreotti, F., Antunes, M. J., Barón-Esquivias, G., Baumgartner, H., Borger, M. A., Carrel, T. P., Bonis, M., Evangelista, A., Falk, V., Lung, B., Lancellotti, P., Pierard, L., Price, S., Schäfers, H. J., Schuler, G., Stepinska, J., Swedberg, K., Takkenberg, J., Oppell, U. O., Windecker, S., Zamorano, J. L., Zembala, M., Esc, Committee For Practice Guidelines, Bax, J. J., Ceconi, C., Dean, V., Deaton, C., Fagard, R., Funck-Brentano, C., Hasdai, D., Hoes, A., Kirchhof, P., Knuuti, J., Kolh, P., Mcdonagh, T., Moulin, C., Popescu, B. A., Reiner, Z., Sechtem, U., Sirnes, P. A., Tendera, M., Torbicki, A., Document Reviewers, Segesser, L., Badano, L. P., Bunc, M., Claeys, M. J., Drinkovic, N., Filippatos, G., Habib, G., Kappetein, A. P., Kassab, R., Lip, G. Y., Moat, N., Nickenig, G., Catherine Otto, Pepper, J., Piazza, N., Pieper, P. G., Rosenhek, R., Shuka, N., Schwammenthal, E., Schwitter, J., Mas, P. T., Trindade, P. T., Walther, T., Joint Task Force on the Management, Valvular Heart Disease, The European Society of Cardiology (ESC), and European Association for Cardio-Thoracic Surgery (EACTS)

39. Polish Registry of Acute Coronary Syndromes (PL-ACS): Characteristics, treatments and outcomes of patients with acute coronary syndromes in Poland

Author

Poloński, L., Ga̧sior, M., Gierlotka, M., Kalarus, Z., Cieśliński, A., Dubiel, J. S., Robert Gil, Ruzyłło, W., Trusz-Gluza, M., Zembala, M., and Opolski, G.

Subjects
guidelines' recommended treatment, wytyczne, ostre zespoły wieńcowe, rokowanie wewnątrzszpitalne, acute coronary syndromes, epidemiology, invasive strategy, epidemiologia, registry, in-hospital outcomes, rejestr

50. Right ventricular function in patients with severe interstitial lung disease: A tissue doppler imaging study

Author

Nowak, J., Jastrzebski, D., Witold Streb, Rozentryt, P., Wojarski, J., Greif, M., Kozielski, J., Polonski, L., Zembala, M., and Kukulski, T.

Subjects
Male, Oxygen, Echocardiography, Vital Capacity, Ventricular Function, Right, Humans, Pulmonary Diffusing Capacity, Female, Carbon Dioxide, Middle Aged, Lung Diseases, Interstitial, Lung Transplantation
Abstract

Tissue Doppler imaging (TDI) can be useful in the evaluation of right ventricular (RV) regional dysfunction due to pulmonary diseases. The aim of the study was to assess RV dysfunction in patients with severe interstitial lung diseases (ILD), using both TDI and conventional transthoracic echocardiography (TTE). The study group consisted of 40 consecutive patients with end-stage ILD referred for lung transplantation (LT). Eighteen of them, mean age 47 +/-12 yr, who fulfilled the ATS/ERS criteria for LT (mean forced vital capacity (FVC) 1.4 +/-0.8 l, mean diffusing capacity for carbon dioxide (DLCO)50% of predicted) constituted the active group, and 22 age-matched patients (mean age 49 +/-12 yr), who did not fulfill these criteria, were placed in the waiting group for LT. We found that among the TDI parameters, the longitudinal peak systolic strain rate (SR) measured at the RV outflow tract, was significantly more negative (-1.1 +/-0.3 vs. -3.2 +/-1.2 s(-1), P=0.03) and the time to peak velocity (TpVEL) in the medial and apical septal segments were shorter (129.9 +/-47.9 vs. 159.2 +/-38.1 ms, P=0.018 and 126.8 +/-44.3 vs. 154.6 +/-40.9 ms, P=0.019) in the patients from the active than those from the waiting group. TTE showed that patients from the active group had significantly lower values of tricuspid annulus plane systolic excursion (TAPSE) (14.3 +/-3.3 vs. 20.6 +/-6.2 mm, P=0.0003) and pulmonary artery acceleration time (PVAT) (70.3 +/-23.3 vs. 96.9 +/-12.4 ms, P=0.0001)compared with those from the waiting group. No other differences were found for other parameters of RV function between the examined groups. In conclusion, severity of lung disease in patients with ILD influences RV systolic dysfunction, which is reflected in both TDI and conventional echocardiographic parameters.

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