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The author focuses on the technique to generate clinical-grade virus-specific T-cell lines targeting seven viruses described U. Gerdemann and colleagues. The author says that the paper of Gerdemann is a logical extension to the approach involving the adoptive transfer of virus-specific T cells after stem cell transplantation (SCT). He suggests that the development of an effective approach is needed for the new viruses described by the team.

While the human NOTCH1 gene initially was cloned as part of a translocation breakpoint in T cell acute lymphoblastic leukemia (T-ALL) tumors, this translocation is present in only a small percentage of T-ALL patients. A recent paper by demonstrates that novel types of activating mutations in the NOTCH1 gene occur in more than half of all T-ALL cases, implicating NOTCH1 as a major player in the etiology of T-ALL. [Copyright &y& Elsevier]

This article presents abstracts of papers published in the July 1, 1990 issue of the "Journal of Investigative Dermatology." Cutaneous T-cell Lymphoma is an indolent lymphoma that begins in the skin and may spread to involve other extracutaneous lymphoid sites. The course may be long and protracted, or explosive and rapid. Differences in skin color among different racial groups are determined by multiple factors involved in the production, packaging, and distribution of melanin in the skin. Melanin is a complex heteropolymer that provides protection for the epidermis by absorbing ultraviolet and visible light across a broad spectrum.

This article presents information about current research in the field of dermatology. According to a research paper published in a 2004 issue of the "British Journal of Dermatology," envelope proteins of the human endogenous retroviruses family are expressed in human normal, psoriatic and atopic skin by immunostaining and western blotting and that their expressions are regulated by ultra violet irradiation. Another study published in a 2004 issue of the "British Journal of Dermatology," looked at which T cell attracting chemokines are involved in allergic contact dermatitis models in mice which differ in their cytokine expression profiles.