Abstract: This paper describes the conditions under which autoimmune T cells enter the central nervous system to attack the local tissue. During a prodromal period preceding the onset of neurological disease, the CNS tissue is converted from its physiological immune-hostile state to an immune-friendly state. At the same time, in the peripheral immune system, activated autoimmune T cells undergo profound changes that allow them to enter through the blood-brain barrier and to finally interact with local autoantigen-presenting cells. Antigen recognition leads to T cell activation and the secretion of inflammatory mediators that are responsible for the development of the inflammatory lesions and the neurological deficits. To cite this article: H. Wekerle, C. R. Biologies 330 (2007). [Copyright &y& Elsevier]
Mouri, S., Bouzbib, C., El Mourabit, H., Schaefer, A., Imbert-Bismut, F., Galanaud, D., Tripon, S., Mallet, M., Rudler, M., Housset, C., Thabut, D., and Weiss, N.
TRYPTOPHAN, SOCIAL anxiety, AMINO acids, CARBOHYDRATES, PHARMACOLOGY
Abstract
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