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1. Palmitoyl-KVK-L-ascorbic acid conjugate improves matrix abnormality associated with skin aging via epigenetic regulation.

Author

Kim, Min-Kyoung, Shin, Mi Hee, Lim, Joo Hyuck, Bae, Jung Soo, Lee, Yu Ri, Shin, Hye Sun, Cho, Soo Ick, Chung, Jin Ho, and Lee, Dong Hun

Subjects
*SKIN aging, *EPIGENETICS, *EXTRACELLULAR matrix, *AGING prevention, *HUMAN abnormalities
Abstract

• DNA methyltransferase 1 (DNMT1) is implicated in epigenetic skin aging. • DVP modulated DNMT1 and extracellular matrix in vitro and in vivo. • Skin anti-aging epigenetic mechanism of DVP was revealed. • Potential of DNMT1 inhibitors as skin anti-aging agents was validated. [ABSTRACT FROM AUTHOR]

Published
2021
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