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Prehydrolysis liquid (PHL) from dissolving pulp and biorefinery industries is rich in saccharides and lignin, being considered as a potential source of value-added materials and platform molecules. This study proposed an environmentally friendly and simple method to prepare morphologically controllable hollow lignin nanoparticles (LNPs) and levulinic acid (LA) from PHL. In the first step, after hydrothermal treatment of PHL with p -toluenesulfonic acid ( p -TsOH), lignin with a uniform molecular weight was obtained to prepare LNPs. The prepared LNPs have an obvious hollow structure, with an average size of 490-660 nm, and exhibit good stability during 30 days of storage. When the as-obtained LNPs were used as a sustained-release agent for amikacin sulfate, the encapsulation efficiency reached over 70% and the release efficiency within 40 h reached 69.2% in a pH 5.5 buffer. Subsequently, the remaining PHL that contains saccharides was directly used for LA production under the catalysis of p -TsOH. At 150 °C for 1.5 h, the LA yield reached 58.4% and remained at 56% after 5 cycles of p -TsOH. It is worth noting that only p -TsOH was used as a reactive reagent throughout the entire preparation process. Overall, this study provided a novel pathway for the integrated utilization of PHL and showed the immense potential of the preparation and application of LNPs.

Widely employed petroleum-based food packaging materials have inflicted irreparable harm on ecosystems, primarily stemming from their non-biodegradable attributes and recycling complexities. Inspired by natural nacre with a layered aragonite platelet/nanofiber/protein multi-structure, we prepared high-barrier composite films by self-assembly of cellulose nanofibrils (CNF), cellulose nanocrystals (CNC), montmorillonite (MMT), polyvinyl alcohol (PVA) and alkyl ketene dimer (AKD). The composite films demonstrated outstanding barrier properties with oxygen vapor transmission of 0.193 g·mm·m -2 ·day -1 and water vapor transmission rates of 0.062 cm 3 ·mm·m -2 ·day -1 ·0.1 MPa -1 , which were significantly lower than those of most biomass-degradable packaging materials. Additionally, the impacts of mixing nanocellulose with various aspect ratios on the tensile strength and folding cycles of the films were examined. The exceptional resistance of the composite films to oil and water provides a novel and sustainable approach to reduce non-biodegradable plastic packaging., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 Elsevier Ltd. All rights reserved.)

Cellulose nanocrystal (CNC) film is known to be one kind of dynamic color-sensing material, capable of reversible color changes in response to varying humidity levels. However, the brittleness, low hygroscopicity and poor homogeneity of these films have hindered their development. To address this limitation, we present a novel approach where we combine natural deep eutectic solvents (NADES) with sorbitol under the influence of circular shear flow to craft a CNC humidity-sensitive film with enhanced flexibility, hygroscopicity and homogeneity. The inclusion of sorbitol and NADES enhances hygroscopicity and improves the flexibility. Surprisingly, the introduction of circular shear flow was found not only to improve homogeneity, macroscopically and microscopically, but also to further enhance flexibility, toughness, and water absorption capability. The resulting composite films demonstrated highly reversible color changes across the whole visible spectrum depending on the relative humidity, showing their capability to be reliable humidity-sensing materials. Thanks to the improved homogeneity and flexibility, the obtained humidity-sensing composite film can be employed in its entirety without the need for cutting, making it a promising candidate for various applications., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 Elsevier B.V. All rights reserved.)

This work deals with assessing the performance of lignin nanoparticles (LNPs) in solving the problem of using salicylic acid as an agrochemical compound, via controlling its release. LNPs, obtained from black liquor, have been used to develop new delivery systems. Gels from chelating of LNPs with chitosan or chitosan nanoparticles (Cs-NPs) in presence or absence of cationic starch are investigated to achieve this essential aim. The nanoparticles are examined by TEM, ATR-FTIR, and XRD techniques. Based on measurements of swelling, encapsulation, release profile, release kinetic modeling of salicylic acid (SA), infrared spectroscopy, thermo-gravimetric analysis and scanning electron microscope the behavior of the investigated nanocomposite gels is assessed. The results show that the SA release profile of Cs-NPs and its nanocomposite with LNPs in phosphate-buffered saline (PBS) (7.4) (51.5-69.4 %) is higher than that of the mixture of water and ethanol (34.9-50.4 %). The release profile in PBS (7.4) demonstrates a trend of prolonged SA release over a 48-hour period. Best control of the SA-release can be achieved by CsNPs-LNPs nanocomposite. Comparing the results with previous literature demonstrates the promising characteristics of these examined gel nanocomposites. The release of SA from nanocomposites is regulated by a diffusion mechanism and follows the Ritger-Peppas and Higuchi models for kinetic release., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 Elsevier B.V. All rights reserved.)

The pre-hydrolysis liquor (PHL) produced during pulp dissolution and biomass refining is mainly composed of hemicellulose and lignin, and it is a potential source for production of value-added materials and platform chemicals; however, their utilization has been a serious challenge. In this study, we proposed a green and simple strategy to simultaneously prepare size-controlled functional lignin nanoparticles (LNPs) and levulinic acid (LA) from PHL as the raw material. The as-prepared LNPs exhibited remarkable stability thanks to the presence of saccharides with abundant oxygen-containing groups and surface charges, which prevented aggregation and maintained long-term storage stability. Trace amounts of the LNPs (≤ 0.2 wt%) could stabilize various Pickering emulsions, even with oil-to-water ratios as high as 5:5 (v/v). Subsequently, the remaining PHL was directly used to produce LA without adding a catalyst; under optimal conditions (160 °C and 1 h), the yield of LA was 56.3 % based on the dry saccharide content in the raw PHL. More importantly, p-toluenesulfonic acid (p-TsOH), the only reactive reagent used during the entire preparation process, including the two preparation steps of the LNPs and LA, was reusable, and the recovery rate was >70 % after five cycles. Overall, this green and simple strategy effectively and comprehensively utilized the PHL and showed potential for producing biobased nanomaterials and platform chemicals., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 Elsevier B.V. All rights reserved.)

This study provides a novel strategy for preparing bio-based antibacterial emulsions stabilized by cellulose nanocrystals (CNCs). Antibacterial ε-polylysine (ε-PL) with a positive charge was introduced into the aqueous phase to modulate the interfacial behavior of CNCs via electrostatic interactions. Pickering emulsions containing ε-PL/CNCs (ε-PL 0.07-0.1 g/L) had significantly better stability, larger emulsion ratio, smaller emulsion droplet diameter, and superior antibacterial ability than emulsions stabilized by CNCs alone. This could be attributed to the formation of a CNC-dense layer at the interface in the continuous phase caused by a reduction of electrostatic repulsion after adding ε-PL. This was confirmed by zeta potential measurements, rheological properties, and bio-freezing scanning electron microscopy. In addition, cinnamaldehyde was introduced into the oil phase to further improve the antibacterial properties of the emulsion, thereby avoiding easy evaporation into water. Our findings provide an innovative solution for preparing bio-based antibacterial emulsions stabilized by ε-PL/CNCs, which will benefit the development of food, medicine, and cosmetic lotions., Competing Interests: Declaration of competing interest The authors declare that there are no potential competing financial interests or personal relationships in the work or publication of this article., (Copyright © 2023. Published by Elsevier B.V.)

This work aims to enhance the performance of the polyvinyl alcohol (PVA) composite by using cellulose nanocrystal (CNC) as reinforcement and copper nanoparticles (CuNPs)/reduced graphene oxide (rGO) as conducting and antimicrobial reagents. Firstly, rGO was loaded onto CuNPs using an eco-friendly microwave method. Different techniques characterized the components and prepared composites, which indicated the incorporation of cellulose nanocrystals and rGO@CuNPs within the polyvinyl alcohol matrix. Utilizing the clear zone of inhibition, the antibacterial test was quantified. Compared to the neat composite, the rGO@CuNPs loaded polyvinyl alcohol/ cellulose nanocrystal composites exhibited no bacterial growth against S. aureus, E. coli, and C. albicans. However, all composites did not have antifungal activity against A. niger. The combination of conductivity and interfacial polarization is the reason for the abrupt increase of permittivity with decreasing frequency. Besides, adding rGO@CuNPs improved the electrical conductivity. DC-Conductivity increased about a decade after adding cellulose nanocrystal to polyvinyl alcohol, then another decade after adding CuONPs. The electric loss modulus representation shows a systematic shift in the peak position towards higher frequencies, decreasing the so-called conductivity relaxation time. This is the main reason for the enhancement of conductivity. The systematic attenuation of peaks' height with increasing conductivity is still unclear., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have influenced the work reported in this paper., (Copyright © 2024. Published by Elsevier B.V.)

Functional materials with under-liquid dual superlyophobicity have generated a great deal of concern from researchers due to their switchable separation ability oil-water mixtures and emulsions. Conceptually, under-liquid dual superlyophobicity is a Cassie state achievable under-liquid through the synergy of an under-liquid double lyophobic surface and the construction of a highly rough surface. However, obtaining an under-liquid dual superlyophobic surface remains difficult due to its thermodynamic contradiction and complex surface composition. Herein, we successfully prepared a functional coating by modifying the mixture of cellulose nanocrystals (CNCs) and nano-TiO 2 with perfluorooctanoic acid (PFOA) via a simple method, then obtained a polyester fiber membrane with under-liquid dual superlyophobicity by roll coating method. The surface wettability of the polyester (PET) membrane was altered, transforming it from the original under-water oleophobic/under-oil superhydrophilic state to the under-water superoleophobic/under-oil superhydrophobic state after coated. The resulting membrane was applied to separate oil and water on-demand. The coated PET membrane exhibited high separation efficiency (>99 %) and high separation flux, effectively separating immiscible oil-water systems as well as oil-in-water and water-in-oil emulsions. The coated PET membrane also demonstrated the ability to perform alternate separation of oil-water mixtures through wetting, washing, and rewetting cycles, with repeated processes up to 10 times without significant reduction in separation efficiency. Furthermore, compared with the previous works, our approach offers a simpler and more convenient method for constructing under-liquid dual superlyophobic surface, making it more suitable for continuous corporate production. This study may provide inspiration for the production and application in large-scale of under-liquid dual superlyophobic membranes., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 Elsevier B.V. All rights reserved.)

Aerogels as drug carriers have the characteristics of a large specific surface area, high porosity and an elastic skeleton structure. Compared with traditional drug carriers, the use of aerogels as drug carriers can avoid the complexity of drug delivery and improve the efficiency of drug loading. In this work, the oxidation of tunicate cellulose nanocrystals (tCNCs) with NaIO 4 was used to prepare di-aldehyde tunicate cellulose nanocrystals (D-tCNCs). Tetracycline (TC) was used as a drug model and pH-responsive drug-loaded aerogels were prepared by the Schiff base reaction between TC and the aldehyde group on D-tCNCs. The chemical structure, crystallinity, morphology, compression properties, porosity, swelling rate and drug loading properties were investigated by FT-IR, XRD, SEM and universal testing machines. The results showed that the porosity and equilibrium swelling ratio of the D-tCNC-TC aerogels were 95.87 % and 17.52 g/g, respectively. The stress of the D-tCNC-TC aerogel at 15 % compression was 0.07 MPa. Moreover, the analysis of drug-loaded aerogels indicated that the drug loading and encapsulation rates of D-tCNC-TC aerogels were 16.86 % and 78.75 %, respectively. In in vitro release experiments, the cumulative release rate of drug-loaded aerogel at pH = 1.2 and pH = 7.4 was 87.5 % and 79.3 %, respectively. These results indicated that D-tCNC-TC aerogels have good drug loading capacity and are pH-responsive in the pH range of 1.2 to 7.4. The prepared D-tCNC-TC aerogels are expected to be applied in drug delivery systems., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2023. Published by Elsevier B.V.)

Ionically conductive hydrogels are an ideal alternative material for applications in wearable flexible sensors to monitor human health. However, producing hydrogels with both high sensitivity and excellent versatility is difficult, and their transparency and UV-blocking properties are significantly limited. Here, with mussel- and gecko-inspired biomimicry, all-biomass-based hydrogels (OGTCGs) with self-adhesive, self-healing, transparent, UV-filtering, frost-resistant, environmentally stable, antibacterial, and biocompatible properties were designed and constructed via a simple one-step approach with a water/glycerol system and borax added without any crosslinker using synergistic dynamic covalent and noncovalent chemistry. The transparency of the OGTCG hydrogel reached 81.06 %, while the added tannic acid-coated cellulose nanocrystal (TA@CNC) induced a UV-blocking effect. The OGTCG hydrogel exhibited a high toughness (218.67 kPa) and modulus (100.32 kPa) reinforced by TA@CNC. The OGTCG hydrogel showed good self-healing abilities with an efficiency of over 90 % after 6 h. In a binary solvent system, the OGTCG hydrogel had environmental stability, as illustrated by density functional theory (DFT), greatly broadening its application range. Moreover, it had an electrical conductivity of 2.3 mS cm -1 and a sensitivity of 3.97. Therefore, with its rapid response and real-time monitoring capabilities, the OGTCG hydrogel shows great potential for applications in monitoring human health., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2023. Published by Elsevier Ltd.)

Air pollution is a major environmental and public health issue. Each year, large amounts of particulate matter (PM) and other harmful pollutants are released into the atmosphere. Conventional polymer nanofiber filters lack the functionality to capture ultrafine PM. As a sustainable alternative, this work developed titanium dioxide (TiO 2 ) nanoparticle surface-modified cellulose nanofiber (CNF) aerogels for PM 2.5 filtration. CNFs were extracted via mechanical disintegration to diameters below 100 nm. The nanofibers were functionalized with 1.0-2.5 wt% TiO 2 nanoparticles using citric acid cross-linking. Cylindrical aerogels were fabricated by freezing and lyophilizing aqueous suspensions. Structural, morphological, thermal, and mechanical properties were characterized. TiO 2 modification increased density (11.8-19.7 mg/cm 3 ), specific surface area (287-370 m 2 /g), and Young's modulus (33.5-125.5 kPa) but decreased porosity (99.6 %-97.7 %), pore size (20.2-15.6 nm) and thermal stability compared to unmodified cellulose aerogels. At 2.5 wt% loading, the optimized aerogels achieved 100 % absorption of 0.1-5 μm particulates owing to reduced pore size. Despite enhanced filtration capabilities, the modified CNF aerogels retained inherent biodegradability, degrading over 70 % within one month of soil burial. This pioneering research establishes TiO 2 functionalized CNF aerogels as promising sustainable alternatives to traditional petroleum-based air filters, representing an innovative approach to creating next-generation nanofiltration materials capable of effectively capturing fine and ultrafine particulate matter pollutants., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2023 Elsevier B.V. All rights reserved.)

In food packaging, biopolymer films are biodegradable films made from biomacromolecule-based natural materials, while biocomposite films are hybrids of two or more materials, with at least one being biodegradable. Bionanocomposites are different than the earlier ones, as they consist of various nanofillers (both natural and inorganic) in combination with biomacromolecule-based biodegradable materials to make good compostable bionanocomposites. In this regard, a new type of material known as bionanocomposite has been recently introduced to improve the properties and performance of biocomposite films. Bionanocomposites are primarily developed for active packaging, but their use in intelligent packaging is also noteworthy. For example, bionanocomposites developed using a hybrid of anthocyanin and carbon dots as intelligent materials have shown their high pH-sensing properties. The natural nanofillers (like nanocellulose, nanochitosan, nanoliposome, cellulose nanocrystals, cellulose nanofibers, etc.) are being employed to promote the sustainability, degradability and safety of bionanocomposites. Overall, this article comprehensively reviews the latest innovations in bionanocomposite films for intelligent food packaging over the past five years. In addition to packaging aspects, the role of nanofillers, the importance of life cycle assessment (LCA) and risk assessment, associated challenges, and future perspectives of bionanocomposite intelligent films are also discussed., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2023 Elsevier B.V. All rights reserved.)

Superabsorbent hydrogels (SAHs) are essential in various applications, including hygienic products like adult incontinence pads. However, synthetic-based super absorbent polymers (SAPs) dominate the market despite being non-biodegradable. Alternatively, bio-based hydrogels, such as sodium alginate (SA)-based hydrogels, offer biodegradable alternatives. In this study, we aimed to enhance the practical applied properties of SA-based hydrogels by grafting SA with acrylic acid (AA) and incorporating cellulose nanocrystals (CNCs). Specifically, we investigated the potential of interpenetrating network (IPN) and semi-interpenetrating network (S-IPN) hydrogels as absorbent materials in adult incontinence pads. The fabricated SAHs were characterized by Fourier transform infrared (FT-IR) spectroscopy and scanning electron microscopy (SEM). They were also evaluated for absorption and rheological properties. The results showed that in IPN/SAHs, the addition of CNCs decreased pore sizes, while in S-IPN/SAHs, CNC incorporation increased pore sizes. The S-IPN/SAHs exhibited a significantly higher free swelling capacity (FSC) with CNCs loading, reaching 142.29 g/g in 0.9 % NaCl solution and 817.4 g/g in distilled water. On the other hand, IPN/SAHs showed a higher storage modulus and lower loss modulus compared to S-IPN/SAHs. Notably, the superior samples from this study showed a 33 % reduction in SAP consumption compared to commercial SAPs, making them more cost-effective for adult incontinence pad manufacturers. Overall, our research demonstrates the potential of interpenetrating and semi-interpenetrating network superabsorbent hydrogels as high-performance absorbent materials. The results offer improved absorbency and cost savings for producers of adult incontinence pads, and bio-based hydrogels like SA-based hydrogels are promising biodegradable alternatives to synthetic-based SAPs., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2023. Published by Elsevier B.V.)

As a green and renewable nanomaterial, cellulose nanocrystals (CNC) have received numerous attention due to the unique structural features and superior physicochemical properties. Conventionally, CNC was isolated from lignocellulosic biomass mostly depending on sulfuric or hydrochloric acid hydrolysis. Although this approach is effective, some critical issues such as severe equipment corrosion, excessive cellulose degradation, serious environmental pollution, and large water usage are inevitable. Fortunately, solid acid hydrolysis is emerging as an economical and sustainable CNC production technique and has achieved considerable progress in recent years. Herein, the preparation of CNC by solid acid hydrolysis was summarized systematically, including organic solid acids (citric, maleic, oxalic, tartaric, p-toluenesulfonic acid) and inorganic solid acids (phosphotungstic, phosphoric, and Lewis acid). The advantages and disadvantages of organic and inorganic solid acid hydrolysis methods were evaluated comprehensively. Finally, the challenges and opportunities in the later exploitation and application of solid acid hydrolysis to prepare CNC in the industrial context are discussed. Considering the future development of this technology in the large-scale CNC production, much more efforts should be made in lowering CNC processing cost, fabricating high-solid-content and re-dispersible CNC, developing value-added applications of CNC, and techno-economic analysis and life cycle assessment on the whole process., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2023. Published by Elsevier B.V.)

Antibacterial biodegradable plastics are highly demanded for food package and disposable medical plastic consumables. Incorporating antibacterial nanoagents into polymer matrices is an effective method to endow polymers with antibacterial activity. However, synthesis of sustainable antibacterial nanoagents with high antibacterial activity via facile approach and well dispersion of them in polymer matrices are still challenging. In this study, polyethyleneimine (PEI) was grafted on surface of cellulose nanocrystals (CNCs) via the oxidation self-polymerization of dopamine (DA) and the Michael addition/Schiff base reaction between DA and PEI. The resulted PEI and polydopamine modified CNCs (PPCs) showed substantially enhanced antibacterial activity and reduced cytotoxicity for NIH3T3 than PEI due to increased local concentration and anchoring of PEI. The minimum concentration of PPCs to achieve antibacterial rate of 99.99 % against S. aureus and E. coli were about 50 and 20 μg/mL, respectively. PPCs displayed outstanding emulsifying ability, and PPC coated polylactic acid (PLA) microspheres were obtained by drying PPC stabilized PLA Pickering emulsion, leading to a well dispersion of PPCs in PLA. PPC/PLA film prepared by hot-pressing displayed great antibacterial performance and enhanced mechanical properties. Therefore, this study proposed a facile approach to fabricate biocompatible antibacterial nanoagents and plastics., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2023 Elsevier B.V. All rights reserved.)

Herein, a green facile approach to improve the flexibility of unbleached bamboo kraft pulp (UBKP) via an immobilized enzyme technology is proposed. Polydopamine (PDA) acts as versatile modification and coating materials of cellulose nanocrystals (CNC) for assembling versatile bio-carriers (PDA@CNC). Cellulase biomacromolecules are efficiently immobilized on PDA@CNC to form cellulase@PDA@CNC nanocomposites. The relative enzyme activity, temperature/pH tolerance, and storage stability of cellulase were significantly improved after immobilization. The degree of polymerization treated UBKP decreased by 5.42 % (25 U/g pulp) compared to the control sample. The flexibility of treated fibers was 6.61 × 10 14 /(N·m 2 ), which was 96.93 % higher (25 U/g) compared to the control and 3.88 times higher than that of the blank fibers. Cellulase@PDA@CNC performs excellent accessibility to fiber structure and induces high degree of fibrillation and hydrolysis of UBKP fibers, which contributes high softness of obtained tissue handsheets. The bio-carrier PDA@CNC within paper framework may further enhance tissue tensile strength. This study proposes a practical and environmentally friendly immobilization approach of cellulase@PDA@CNC for improving the hydrolysis efficiency and flexibility of UBKP fibers, which provides the possibility to maintain the strength of tissue paper while improving its softness, thus broadening the high-value application of immobilized enzyme technology in tissue production., Competing Interests: Declaration of competing interest There are no conflicts to declare., (Copyright © 2023. Published by Elsevier B.V.)

The engineering of a new monodisperse colloid with a sea urchin-like structure with a large complex internal structure is reported, in which silica surfaces are bridged by an aromatic organic cross-linker to serve as a nanocarrier host for drugs such as doxorubicin (DOX) against breast cancer cells. While dendritic fibrous nanosilica (DFNS) was employed and we do not observe a dendritic structure, these particles are referred to as sea urchin-like nanostructured silica (SNS). Since the structure of SNS consists of many silica fibrils protruding from the core, similar to the hairs of a sea urchin. For the aromatic structured cross-linker, bis(propyliminomethyl)benzene (b(PIM)B-S or silanated terephtaldehyde) were employed, which are prepared with terephtaldehyde and 3-aminopropyltriethoxy-silane (APTES) through a simple Schiff base reaction. b(PIM)B-S bridges were introduced into SNS under open vessel reflux conditions. SPS refers to the product obtained by incorporating the cross-linker b(PIM)B-S in ultra-small colloidal SNS particles. In-situ incorporation of DOX molecules resulted in SPS-DOX. The pH-responsive SPS nanocomposites were tested as biocompatible nanocarriers for controllable doxorubicin (DOX) delivery. We conclude that SPS is a unique colloid which has promising potential for technological applications such as advanced drug delivery systems, wastewater remediation and as a catalyst for green organic reactions in water., Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2023. Published by Elsevier Inc.)

Hydrogen peroxide (H 2 O 2 ) acts as an important reactive oxygen species (ROS) and maintains the redox equilibrium in organisms. Imbalance of H 2 O 2 concentration is associated with the development of many diseases. Traditional small molecular based fluorescent probes often show drawbacks of cytotoxicity and easily metabolic clearance. Herein, a chitosan-based two-photon fluorescent nanoprobe (DC-BI) was constructed and applied for H 2 O 2 detection in live organisms. DC-BI was composed by chitosan nanoparticles and a two-photon fluorophore of naphthalimide analogues (BI) with H 2 O 2 -responsive property. The structure of DC-BI was characterized by NMR, FTIR, XPS, XRD, DLS and MLS analyses. As study shown, the nanoprobe DC-BI exhibited improved distribution stability and smaller cytotoxicity. In the presence of H 2 O 2 , both the absorption and emission spectra show dramatic changes, the fluorescence intensity at 580 nm obviously enhanced. Furthermore, fluorescence imaging results indicate that DC-BI is capable of imaging endogenous H 2 O 2 in cells and zebrafish. The design and development of chitosan-based nanoprobe DC-BI has provided a general example of nanoprobe construction with excellent distribution stability, two-photon property, and biocompatibility., Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2023 Elsevier B.V. All rights reserved.)

In this study, the formation of clove essential oil loaded chitosan nanocapsules (CEO/CS-NCs) was achieved by the ionotropic gelation technology. The spherical shape and core-shell structure of CEO/CS-NCs were characterized by SEM, TEM, and FT-IR. CEO/CS-NCs have a reasonable encapsulation efficiency rate of 39 % and an average size of 253.63 nm. The simulated release of CEO/CS-NCs in a citric acid buffer solution shows that the nano-encapsulation technology could control the sustained release of clove essential oil (CEO). The shelf life of untreated blueberries at room temperature is only about 3 days, while CEO/CS-NCs combined with low-temperature storage can extend the shelf life to about 12 days. The quality characteristic of blueberries, including fruit firmness and moisture content, were effectively maintained, and the rotting rate of blueberries was significantly reduced with CEO/CS-NCs. As a natural preservative, CEO/CS-NCs have a good antioxidant activity close to the commercial antioxidant butylated hydroxytoluene (BHT) and a high antibacterial activity against pathogenic bacteria (PB) isolated from naturally occurring blueberries. Therefore, this study not only gives a theoretical basis for the development of CEO as a commercial preservative but also provides a practical solution to solve the protection challenge of preserving blueberries., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2023 Elsevier B.V. All rights reserved.)

Polysaccharides, due to their remarkable features, have gained significant prominence in the sustainable production of nanoparticles (NPs). High market demand and minimal production cost, compared to the chemically synthesised NPs, demonstrate a drive towards polysaccharide-based nanoparticles (PSNPs) benign to environment. Various approaches are used for the synthesis of PSNPs including cross-linking, polyelectrolyte complexation, and self-assembly. PSNPs have the potential to replace a wide diversity of chemical-based agents within the food, health, medical and pharmacy sectors. Nevertheless, the considerable challenges associated with optimising the characteristics of PSNPs to meet specific targeting applications are of utmost importance. This review provides a detailed compilation of recent accomplishments in the synthesis of PSNPs, the fundamental principles and critical factors that govern their rational fabrication, as well as various characterisation techniques. Noteworthy, the multiple use of PSNPs in different disciplines such as biomedical, cosmetics agrochemicals, energy storage, water detoxification, and food-related realms, is accounted in detail. Insights into the toxicological impacts of the PSNPs and their possible risks to human health are addressed, and efforts made in terms of PSNPs development and optimising strategies that allow for enhanced delivery are highlighted. Finally, limitations, potential drawbacks, market diffusion, economic viability and future possibilities for PSNPs to achieve widespread commercial use are also discussed., Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2023 Elsevier B.V. All rights reserved.)

Two kinds of nanocellulose (cellulose nanofibrils (CNFs) and cellulose nanocrystals (CNCs) were synthesized from pomelo peels via a facile approach of TEMPO oxidation and sulfuric acid treatment respectively. The FTIR results illustrated that hemicelluloses and lignin were completely removed from the pomelo peel cellulose substrate. The obtained CNFs and CNCs possessed a uniform morphology and nanoscale particle size. The stability of CNF-based Pickering emulsions was higher than that of emulsions stabilized with CNCs, due to the formation of gel structure induced by the CNFs' longer fibrils. Increased oil fractions enhanced the viscoelasticity of CNF-based Pickering emulsions. The in vitro digestion results suggested that increased oil fractions decreased the lipolysis degree, as a result of the larger droplet size and higher viscoelasticity of emulsion. The release of lycopene showed a trend similar to that of FFA release, suggesting that higher oil fractions were beneficial for controlling lycopene release during gastrointestinal digestion., Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2023 Elsevier Ltd. All rights reserved.)

In this study, we prepared spherical cellulose nanocrystals (S-CNCs) and stabilized n-hexadecane Pickering emulsions in conjunction with graphene oxide (GO), exploring the interaction between S-CNCs and GO in the emulsions. Both S-CNCs and GO are amphiphilic and synergistically stabilize Pickering emulsions by adhering to the surface of oil droplets and within the emulsion space through hydrogen bonding. GO's two-dimensional sheets assemble into a 3D network structure, further improving the stability of Pickering emulsions. Consequently, the stability of Pickering emulsions can be adjusted by altering the S-CNCs/GO ratio, modifying the spatial distribution relationship of stabilizers in the emulsions. At an S-CNCs concentration of 1 g/L and a GO concentration of 3 g/L, the Pickering emulsion demonstrated excellent stability and exhibited no delamination after 31 days of storage. Thus, the S-CNCs/GO combination serves as an effective Pickering emulsion stabilizer, utilizing the synergistic effect between the two components., Competing Interests: Declaration of competing interest The authors declare that there are no potential competing financial interests or personal relationships in the work, publication of this article., (Copyright © 2023. Published by Elsevier B.V.)

Biopolymers with excellent biocompatibility and biodegradability show great potential for designing drug nanocarriers, while it's difficult to fabricate smart vehicles with multiple switching (size, surface, shape) based on biopolymers alone. Here, we report a dual size/charge-switchable and multi-responsive doxorubicin-loaded gelatin-based nanocluster (DOX-icluster) for improved tumor penetration and targeted anti-tumor therapy. The DOX-icluster was electrostatically assembled from folic acid and dimethylmaleic anhydride modified gelatin (FA-GelDMA) and small-sized DOX-loaded NH 2 modified hollow mesoporous organosilicon nanoparticles (DOX-HMON-NH 2 ). DOX-icluster had an initial size of about 199 nm at neutral pH. After accumulation in tumor tissue, the DMA bond of FA-GelDMA was cleaved and gelatin was degraded by matrix metalloproteinase (MMP-2), thus 48 nm and positively charged DOX-HMON-NH 2 was released to facilitate penetration and cell internalization. DOX-HMON-NH 2 was further degraded by intracellular glutathione (GSH) with releasing 48.1 % of DOX. The cellular uptake results indicated that the fabricated icluster promoted the uptake of DOX by 4T1 cells. With enhanced penetration efficacy, the tumor spheroids volume treated with DOX-icluster was reduced to 15.1 % on day 7. This cytocompatible multi-responsive gelatin-based icluster with size-shrinking and charge-reversible characteristics may be used as a significant drug carrier for tumor therapy., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2023 Elsevier B.V. All rights reserved.)

Cell-free and cell-loaded constructs are used to bridge the critical-sized bone defect. Oxidative stress at the site of the bone defects is a major interference that slows bone healing. Recently, there has been an increase in interest in enhancing the properties of three-dimensional scaffolds with free radical scavenging materials. Cerium oxide nanoparticles (CNPs) can scavenge free radicals due to their redox-modulating property. In this study, freeze-drying was used to fabricate CG-CNPs nanocomposite scaffolds using gelatin (G), chitosan (C), and cerium oxide nanoparticles. Physico-chemical, mechanical, and biological characterization of CG-CNPs scaffolds were studied. CG-CNPs scaffolds demonstrated better results in terms of physicochemical, mechanical, and biological properties as compared to CG-scaffold. CG-CNPs scaffolds were cyto-friendly to MC3T3-E1 cells studied by performing in-vitro and in-ovo studies. The scaffold's antimicrobial study revealed high inhibition zones against Gram-positive and Gram-negative bacteria. With 79 % porosity, 45.99 % weight loss, 178.25 kPa compressive modulus, and 1.83 Ca/P ratio, the CG-CNP 2 scaffold displays the best characteristics. As a result, the CG-CNP 2 scaffolds are highly biocompatible and could be applied to repair bone defects., Competing Interests: Declaration of competing interest The authors have no conflict of interest., (Copyright © 2023 Elsevier B.V. All rights reserved.)

Protection coatings with self-healing ability can significantly enhance their anti-corrosion properties and service life. In this study, self-healing waterborne polyurethane (WPU) coatings with high transparence and haze were facile fabricated via cellulose nanocrystal (CNC) stabilized linseed oil (LO) Pickering emulsion. Sustainable CNCs displayed outstanding emulsifying ability and stability to stabilize LO Pickering emulsion. The size of LO Pickering emulsion droplets decreases with the CNC concentration, while the emulsion fraction and surface coverage by CNCs increase with CNC concentration, leading to a more stable Pickering emulsion. The self-healing rates of WPU coatings at varied time, temperature, CNC and catalyst concentration were investigated. Higher temperature, larger emulsion droplets, and with driers employed as catalysts generally lead to faster self-healing rate. The WPU self-healing coatings displayed much better abrasion resistance and mechanical properties than pristine WPU due to the incorporation of CNCs. Moreover, the WPU self-healing coatings show a high transparence and haze due to light scattering, and their applications as coatings of lamp covers and glass to achieve uniform light distribution and privacy protection with high light transmission were further demonstrated., Competing Interests: Declaration of competing interest The authors declare no competing financial interest., (Copyright © 2023 Elsevier B.V. All rights reserved.)

Photonic crystal materials based on cellulose nanocrystals (CNC), which are environmentally responsive and green, have attracted widespread attention. To overcome the brittleness of CNC films, many researchers have explored functional additives to improve their performance. In this study, a new green deep eutectic solvents (DESs) and an amino acid-based natural deep eutectic solvents (NADESs) were introduced into CNC suspensions for the first time, and hydroxyl-rich small molecules (glycerol, sorbitol) and polymers (polyvinyl alcohol, polyethylene glycol) were coassembled with the DESs and NADESs to form three-component composite films. The CNC/G/NADESs-Arg three-component film reversibly changed color from blue to crimson as the relative humidity rose from 35 % to 100 %; additionally, the elongation at break increased to 3.05 %, and the Young's modulus decreased to 4.52 GPa. The hydrogen bond network structure provided by trace amounts of the DESs or NADESs not only improved the mechanical properties of the composite films but also increased their water absorption capacities without destroying their optical activities. This allows for the development of more stable CNC films and creates potential for biological applications in the future., Competing Interests: Declaration of competing interest The authors declare no competing financial interests., (Copyright © 2023 Elsevier B.V. All rights reserved.)

Structural color is an eye-catching phenomenon in nature, which originates from the synergistic effect of cholesteric structure inside living organisms and light. However, biomimetic design and green construction of dynamically tunable structural color materials have been a great challenge in the field of photonic manufacturing. In this work, the new ability of L-lactic acid (LLA) to multi-dimensionally modulate the cholesteric structures constructed from cellulose nanocrystals (CNC) is revealed for the first time. By studying the molecular-scale hydrogen bonding mechanism, a novel strategy that electrostatic repulsion and hydrogen bonding forces jointly drive the uniform arrangement of cholesteric structures is proposed. Due to the flexible tunability and uniform alignment of the CNC cholesteric structure, different encoded messages were developed in the CNC/LLA (CL) pattern. Under different viewing conditions, the recognition information of different digits will continue to reversibly and rapidly switch until the cholesteric structure is destroyed. In addition, the LLA molecules facilitated the more sensitive response of the CL film to the humidity environment, making it exhibit reversible and tunable structural colors under different humidity. These excellent properties provide more possibilities for the application of CL materials in the fields of multi-dimensional display, anti-counterfeiting encryption, and environmental monitoring., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2023 Elsevier B.V. All rights reserved.)

Cancer immunity is dependent on dynamic interactions between T cells and dendritic cells (DCs). Polymer-based nanoparticles target DC receptors to improve anticancer immune responses. In this paper, DC surface receptors and their specific coupling natural ligands and antibodies are reviewed and compared. Moreover, reaction mechanisms are described, and the synergistic effects of immune adjuvants are demonstrated. Also, extracellular-targeting antigen-delivery strategies and intracellular stimulus responses are reviewed to promote the rational design of polymer delivery systems., Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2023 Elsevier B.V. All rights reserved.)

A wide range of applications are available for kraft lignin (KL). However, the dark color and wide size distribution of KL make it challenging to use in cosmetics and nanoparticle preparation. In this study, we fractionated KL from a paper-making enterprise using ultrafiltration membrane fractionation, and obtained four kinds of lignin with different molecular weights, namely ultrafiltration lignin (UL). Following that, lignin nanoparticles (ULNPs) were formed by self-assembly from four types of UL. Analyzing the UL and ULNP properties, the low molecular weight lignin, such as ULA, exhibited good antioxidant properties (89.47 %, 5 mg/mL), high brightness (ISO% = 7.55), high L ⁎ value (L ⁎  = 72.3) and low polydispersity index (PDI = 1.41). The ULNP showed a narrow size distribution (0.8-1.4 m) and high dispersibility in sunscreen. When ULNP was added to sunscreen with 5 % load, its sun protection factor (SPF) value increased from 14.93 to 63.74. Therefore, this study offered an effective way for the comprehensive utilization of pulping waste KL., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2023. Published by Elsevier B.V.)

In the current work, we present a renewable alternative coating formulation made of durable titania nanoparticles and oxidized nanocellulose (TiO 2 NPs@OCNs) nanocomposites and sodium alginate (SA), to create an environmentally friendly and secure food packaging paper. OCNs sugarcane fibers are firstly hydrolyzed using ammonium persulphate (APS). Then, TiO 2 NPs@OCNs nanocomposites are made in situ with OCNs using a green water-based sol-gel synthesis. Gram (+) microorganisms as well as Gram (-) bacteria are used to test the antibacterial properties of the TiO 2 NPs@OCN dispersions. The results show that the TiO 2 NP@OCNs significantly decreases the growth for all bacterial species. The TiO 2 NP@OCNs nanocomposites are mixed with SA, and the resulting formulations are used to coat paper sheets. The corresponding physicochemical properties are evaluated using FTIR, TGA, AFM, SEM, and EDX. Furthermore, the mechanical strength, air permeability, and water vapor characteristics of the paper sheets treated with SA/TiO 2 NPs@OCN are carried out, resulting in a great improvement of these properties. Finally, the SA/TiO 2 NPs@OCNs coated papers have been used as packaging for strawberries. The findings demonstrate that coated papers could preserve strawberry quality better than unpacked fruit and extend strawberry shelf life from 6 to 18 days., Competing Interests: Declaration of competing interest The authors declare that there are no conflicts of interest., (Copyright © 2023 Elsevier B.V. All rights reserved.)

The charge plays an important role in cellulose nanocrystal (CNC) self-assembly to form liquid crystal structures, which has rarely been systematically explored. In this work, a novel technique combining atomic force microscopy force and atomistic molecular dynamics simulations was addressed for the first time to systematically investigate the differences in the CNC self-assembly caused by external positive and negative charges at the microscopic level, wherein sodium polyacrylate (PAAS) and chitosan oligosaccharides (COS) were used as external positive and negative charge additives, respectively. The results show that although the two additives both make the color of CNC films shift blue and eventually disappear, their regulatory mechanisms are, respectively, related to the extrusion of CNC particles by PAAS and the reduction in CNC surface charge by COS. The two effects both decreased the spacing between CNC particles and further increased the cross angle of CNC stacking arrangement, which finally led to the color variations. Moreover, the disappearance of color was proved to be due to the kinetic arrest of CNC suspensions before forming chiral nematic structure with the addition of PAAS and COS. This work provides an updated theoretical basis for the detailed disclosure of the CNC self-assembly mechanism.

The morphology of metal oxide is a crucial factor for improving of catalysis properties. As a renewable and environmentally friendly biomass material, cellulose has been widely used to induce the morphology of semiconductors. The contributions of cellulose hydroxyl groups and spatial hindrance in tailoring Al doped ZnO (AZO) morphologies were investigated. The morphology of AZO could be gradually induced from flake-like to flower-like with the increase of cellulose hydroxyl content per unit volume. At the same time, the changes in spatial hindrance had no apparent effect on the morphology of AZO. So the cellulose hydroxyl groups that act to induce the in situ growth of AZO nanoparticles on cellulose substrates. The results further confirmed the strong interaction between cellulose hydroxyl groups and Zn 2+ . In addition, the photocatalytic activities of Al-doped ZnO/cellulose nanocomposites (AZOC) with different morphologies were evaluated by the degradation of bisphenol A (BPA). The high hydroxyl contents of cellulose substrates contributed to the growth of flower-like AZO with high light utilization and photocatalytic activity. This work proposed cleaner strategies to modify semiconductor morphologies for photocatalysis by regulating the content of cellulose hydroxyl contents., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2023 Elsevier B.V. All rights reserved.)

Bacterial infection has become one of the major threats to human health all over the world, and the development and application of antibacterial materials has drawn great attention. Based on the Schiff-base structure, ZnONPs@ACFs are obtained by loading zinc oxide nanoparticles (ZnONPs) on amino cellulose fibers (ACFs) in-situ through the coordination of amino groups with metal ions. The results of FT-IR, XRD and UV-vis demonstrate that ZnONPs are successfully loaded and uniformly dispersed on ACF surface, and the ACFs maintain intact morphology observed by SEM. Furthermore, the zero-span tensile strength of ZnONPs@ACFs is 66.48 N/cm (ROL: 24.98 N/cm/s) under the optimum conditions, which indicates that ZnONPs@ACFs have a certain strength and can be used to make antibacterial sheet materials via paper-making wet-forming process. Accordingly, the ZnONPs@ACF composites show inhibition zones of 4.95 mm and 1.10 mm against E. coli and S. aureus, respectively. The new cellulose-based antibacterial materials demonstrate potential applications in the field of food packaging and biological medicine etc., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2022. Published by Elsevier B.V.)

Lignin nanoparticles (LNPs), as one of green and sustainable biological macromolecules, have attracted great attention owing to their promising potentials in many valorized fields. However, the lignin heterogeneity seriously restricts the controllable preparation of LNPs. Herein, a facile nanogrinding activation combining anhydrous ethanol dissolution process was developed to efficiently homogenize lignin prior to gradient ethanol fractionation. Two lignin fractions were obtained from nanogrinding activation/ethanol dissolution followed by gradient ethanol fractionation: L-fractions and S-fractions. Therefore, monodispersed LNPs with unique concave hollow nanostructure and large particle size, and monodispersed LNPs with solid core nanostructure and small particle size were successfully prepared from L-fractions and S-fractions, respectively, via a GVL/water anti-solvent method. The proposed LNPs formation mechanisms facilitated by nanogrinding activation/ethanol dissolution treatment were demonstrated. This study put forwards a facile and green integrated approach for monodispersed LNPs preparation with controllable morphology and particle size., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2022 Elsevier B.V. All rights reserved.)

The preparation of carboxylated cellulose nanocrystals (cCNCs) and their stabilization in oil-in-water (O/W) Pickering emulsions hold great potential for application and research value. In this work, a novel integrated oxidation strategy was proposed to prepare needle-like cCNCs by sodium periodate (NaIO 4 )/Fenton (SF-cCNCs) with considerable yield (58.58 %), plentiful carboxyl groups (1.28 mmol/g), and high crystallinity (83.3 %). The distinctive features of smaller size and high viscosity accelerated the as-prepared SF-cCNCs to be used in stabilizing Pickering emulsion. Moreover, the effects of oil-water ratio (OWR), SF-cCNCs content, pH, and sodium chloride (NaCl) content on the stability of SF-cCNCs-stabilized Pickering emulsions were also investigated systematically. Interestingly, the stability of the as-obtained emulsions was dependent on pH and salt. Afterwards, the rheological behaviors validated that the emulsion viscosity increased rapidly after adding NaCl, which was dominated by the elastic behavior. Finally, the main stabilization mechanism was confirmed to be interfacial adsorption of SF-cCNCs rather than the formation of spatial network structures between droplets. This study reports a synthetic strategy to efficiently prepare SF-cCNCs, endowing the SF-cCNCs stabilized Pickering emulsion with environmentally friendly, long-term stable and highly anti-agglomeration abilities for cosmetics and food products., Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2022 Elsevier Inc. All rights reserved.)

Here, we describe the all-aqueous bicontinuous emulsions with cholesteric liquid crystal domains through hierarchical colloidal self-assembly of nanoparticles. This is achieved by homogenization of a rod-like cellulose nanocrystal (CNC) with two immiscible, phase separating polyethylene glycol (PEG) and dextran polymer solutions. The dispersed CNCs exhibit unequal affinity for the binary polymer mixtures that depends on the balance of osmotic and chemical potential between the two phases. Once at the critical concentration, CNC particles are constrained within one component of the polymer phases and self-assemble into a cholesteric organization. The obtained liquid crystal emulsion demonstrates a confined three-dimensional percolating bicontinuous network with cholesteric self-assembly of CNC within the PEG phase; meanwhile, the nanoparticles in the dextran phase remain isotropic instead. Our results provide an alternative way to arrest bicontinuous structures through intraphase trapping and assembling of nanoparticles, which is a viable and flexible route to extend for a wide range of colloidal systems.

In recent years, lignin nanoparticles (LNP) have gained tremendous and deep research in the field of functional composites because of their many advantages such as abundant, non-toxic, affordable, green, eco-friendly, biodegradable and biocompatible features along with antioxidant, antibacterial and UV-absorbing abilities. At present, numerous pioneering works have been devoted to the development of LNP-based composites with multiple functions. Herein, we comprehensively reviewed the latest research progress correlated with LNP-filled functional composites. This overview focused on the application of LNP as reinforcement, crosslinker, UV-protectant, antioxidant, antimicrobial and adhesive agents for functional composites. Additionally, the challenges and future outlooks for further exploiting and utilization of LNP in the functional composites were discussed., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2022. Published by Elsevier B.V.)

The poor water solubility, large particle size, and low accessibility of cellulose, the most abundant bioresource, have restricted its generalization to carbon dots (CDs). Herein, nitrogen and sulfur co-doped fluorescent carbon dots (N, S-CDs) were hydrothermally synthesized using cellulose nanocrystals (CNC) as a carbon precursor, exhibiting a small particle size and excellent aqueous dispersion. Thiourea was selected as a nitrogen and sulfur dopant to introduce abundant fluorescent functional groups into N, S-CDs. The resulting N, S-CDs exhibited nanoscale size (6.2 nm), abundant functional groups, bright blue fluorescence, high quantum yield (QY = 27.4%), and high overall yield (16.2%). The excellent optical properties of N, S-CDs endowed it to potentially display a highly sensitive fluorescence "turn off" response to rutin. The fluorescence response for rutin allowed a wide linear range of 0-40 mg·L -1 , with a limit of detection (LOD) of 0.02 μM, which revealed the potential of N, S-CDs as a rapid and simple sensing platform for rutin detection. In addition, the sustainable and large-scale production of the N, S-CDs in this study paves the way for the successful high-value utilization of cellulose.

Oral administration of combinations of specific nutrients and nutraceuticals can provide synergistic health benefits to humans. In this work, zein/carboxymethyl cellulose composite nanoparticles were successfully prepared using antisolvent precipitation methods. Zein/carboxymethyl cellulose nanoparticles with the smallest size (204.6 nm) were formed when the mass ratio of zein to CMC was 2 : 1. Hydrogen bonding and hydrophobic interactions were dominant binding forces to stabilize the composite nanoparticles. Quercetin and resveratrol were then encapsulated within these nanocarriers, which improved their resistance to both light and thermal degradation. Encapsulation of the nutraceuticals was shown to delay their release under simulated gastrointestinal conditions, which may be beneficial for some applications. Moreover, encapsulation increased the in vitro bioaccessibility of the quercetin and resveratrol. Our results indicate that zein/carboxymethyl cellulose nanoparticles can be used to co-deliver combinations of bioactive compounds, which may be useful for the development of functional foods, supplements, and pharmaceuticals.

The promising features of most bacterial celluloses (BC) promote the continuous mining for a cost-effective production approach toward wide and sustainable applications. Herein, cantaloupe peels (CP) were successfully implemented for sustainable BC production. Results indicated that the enzymatically hydrolyzed CP supported the maximum BC production of approximately 3.49 g/L when used as a sole fermentation media. The produced BC was fabricated with polyvinyl alcohol (PVA) and chitosan (Ch), and loaded with green synthesized copper oxide nanoparticles (CuO-NPs) to improve its biological activity. The novel composite showed an antimicrobial activity against several human pathogens such as Staphylococcus aureus, Streptococcus mutans, Salmonella typhimurium, Escherichia coli, and Pseudomonas fluorescens. Furthermore, the new composite revealed a significant in vitro anticancer activity against colon (Caco-2), hepatocellular (HepG-2), and breast (MDA) cancer cells, with low IC 50 of 0.48, 0.27, and 0.33 mg/mL for the three cell lines, respectively. On the other hand, the new composite was remarkably safe for human skin fibroblast (HSF) with IC 50 of 1.08 mg/mL. Interestingly, the composite membranes exhibited lethal effects against all stages of larval instar and pupal stage compared with the control. In this study, we first report the diverse potential applications of BC/PVA/Ch/CuO-NPs composites based on green synthesized CuO-NPs and sustainably produced BC membrane., (© 2022. The Author(s).)

Recent breakthroughs in the field of nanoparticle-based therapeutic delivery methods have changed the standpoint of cancer therapy by effectively delaying the process of disease development. Nanoparticles have a unique capacity of good penetrating ability than other therapeutic leads used in traditional therapeutics, and also, they have the highest impact on disease management. In the current study isolongifolene-loaded Chitosan nanoparticles have been formulated, synthesized and then characterized by the use of Fourier Transform Infrared Spectroscopy, X-ray Diffraction, Scanning Electron Microscopy and Transmission Electron Microscopy. Further, the characterized chitosan nano formulation was evaluated for hemocompatibility, plasma stability, and in-vitro release. Isolongifolene-loaded chitosan nanoparticles were found to be compatible with plasma and also, they exhibited a constant release pattern. Hence, chitosan-loaded nanoparticles could be employed as an excellent adjuvant in cancer therapeutic, to combat the multi-drug resistance in solid tumors., (© 2022. The Author(s).)

Although many treatments have been developed for oncotherapy, the lack of effective imaging guidance in the therapeutic process is still an urgent problem to be solved. In this study, magnetic resonance contrast agent (Gd) chelated on CuS nanoparticles and glucose oxidase (GOx) were coloaded into mesoporous silica nanoparticles (MSNs) to form GOx-Gd-CuS@MSNs, in which the Gd provided magnetic resonance imaging (MRI) for therapeutic process monitor while GOx could catalyze the generation of H 2 O 2 to enhance the photodynamic therapy (PDT). The in vitro results show that under near-infrared (NIR) laser irradiation (2 W·cm -2 , 5 min), temperature rapidly increased by approximately 30 °C for the accumulation of heat. At the same time, GOx on GOx-Gd-CuS@MSNs effectively consumed glucose to produce a large amount of H 2 O 2 , which was used to augment PDT through producing highly toxic hydroxyl radicals (·OH) and singlet oxygen ( 1 O 2 ). The photothermal and augmented-photodynamic could induce apoptosis and death of tumor cells. More importantly, the study found that GOx-Gd-CuS@MSNs had MRI performance, which provided imaging guidance during the treatment process, and it can monitor the diffusion of water molecules in the tumor tissue during the treatment and microcirculation perfusion of capillary network. These results indicate that the nanomaterial produced significant synergistic therapeutic effects through photothermal and photodynamic forces, meanwhile showed excellent spatial resolution and deep tissue penetration in imaging., (Copyright © 2022. Published by Elsevier Inc.)

Collagen (Col) films were reinforced by celluloses in different geometries: microcrystalline cellulose (MCC), cellulosic fines (CF), cellulose nanofiber (CNF) and cellulose nanocrystals (CNC). The reinforcement mechanisms were investigated by the elastoplasticity and fracture appearance. Compared with the fracture stress of collagen film (67.5 MPa), the Col-CNF films effectively borne the stress (95.8 MPa) by intercrystalline fracture, ascribing the abundant hydrogen bonding and mechanical locking between cellulose and collagen. The toughness of Col-CF films was increased by the interfibrillar slippage of CF and pull-off of CF within the matrix, improving the strain-to-break from 8.37% to 12.13%. The films added with MCC and CNC weaken the mechanical behavior, due to the defects and lack of mechanical locking. Besides, the effects of celluloses' geometries on the thickness, density, water-tightness, thermal stability, crystallinity and FTIR of films were also investigated. These provide the evidence that the geometries of fillers diversely improve the behaviors of collagen film offering strategies for the film with adjustable mechanical properties., (Copyright © 2022. Published by Elsevier B.V.)

Lignin nanoparticles, the innovative achievements in the development and utilization of lignin, combine the structural characteristics of nanomaterials and lignin molecules and have a wide range of applications. In this review, we summarize the methods for preparing lignin nanoparticles by solvent exchange method, mechanical method, biological enzymatic method, interface polymerization/crosslinking method, and spray freezing method, and emphatically introduce the application prospects of lignin nanoparticles in ultraviolet protection, antibacterial, nano-filler, drug delivery, and adsorption, aiming to provide a certain reference direction for additional high-value applications of lignin nanoparticles.

Inorganic nanoparticles (INPs) have been paid great attention in the field of oncology in recent past years since they have enormous potential in drug delivery, gene delivery, photodynamic therapy (PDT), photothermal therapy (PTT), bio-imaging, driven motion, etc. To overcome the innate limitations of the conventional INPs, such as fast elimination by the immune system, low accumulation in tumor sites, and severe toxicity to the organism, great efforts have recently been made to modify naked INPs, facilitating their clinical application. Taking inspiration from nature, considerable researchers have exploited cell membrane-camouflaged INPs (CMCINPs) by coating various cell membranes onto INPs. CMCINPs naturally inherit the surface adhesive molecules, receptors, and functional proteins from the original cell membrane, making them versatile as the natural cells. In order to give a timely and representative review on this rapidly developing research subject, we highlighted recent advances in CMCINPs with superior unique merits of various INPs and natural cell membranes for cancer therapy applications. The opportunity and obstacles of CMCINPs for clinical translation were also discussed. The review is expected to assist researchers in better eliciting the effect of CMCINPs for the management of tumors and may catalyze breakthroughs in this area., (© 2022. The Author(s).)

Cellulose nanocrystals (CNCs) offer excellent mechanical properties. However, measuring the strength by performing reliable experiments at the nanoscale is challenging. In this paper, we model Iβ crystalline cellulose using reactive molecular dynamics simulations. Taking the fibril twist into account, structural changes and hydrogen-bonding characteristics of CNCs during the tensile test are inspected and the failure mechanism of CNCs is analyzed down to the scale of individual bonds. The C4-O4 glycosidic bond is found to be responsible for the failure of CNCs. Finally, the effect of strain rate on ultimate properties is analyzed and a nonlinear model is used to predict the ultimate strength of 9.2 GPa and ultimate strain of 8.5% at a 1 s -1 strain rate. This study sheds light on the applications of cellulose in nanocomposites and further modeling of cellulose nanofibres.

There is a strong interest in developing environmentally friendly synthesis approaches for making polyurethane elastomers (PUE) with desirable mechanical performance and flame retardancy suitable for a variety of applications. Hence, in this study, a novel nano functionalized lignin nanoparticle (Nano-FL) containing nitrogen (N) and phosphorus (P) moieties was developed via mild grafting reactions combined with the ultrasound method. The Nano-FL incorporated in the PUE acted as both crosslinking agents and flame retardants. The novel Nano-FL showed good compatibility and dispersibility in the PUE matrix, thereby overcoming the weakening effect of adding traditional lignin flame retardants on the mechanical properties of the PUE materials. PUE/Nano-FL exhibited strong tensile properties. Compared with control neat PUE, with 10 wt% of Nano-FL addition, the PUE attained a limiting oxygen index as high as 29.8% and it also passed the UL-94 V-0 rating. Furthermore, Cone Calorimetry Test (CCT) showed that the addition of Nano-FL not only reduced the heat release rate and the total heat release but also decreased the total smoke production rate during combustion. The char residues of PUEs with Nano-FL showed a high oxidation resistance with dense and continuous structural morphologies. The combined barrier and quenching effects of the char layer provided excellent flame retardancy performance. The novel Nano-FL developed in this study showed excellent promises as green functional additives for enhancing mechanical, thermal and flame retardancy performance of a wide range of polymers., (Copyright © 2022. Published by Elsevier B.V.)

Deacidification and surface self-cleaning are of great significance for the long-term preservation of historic literature. Herein, a superhydrophobic self-cleaning coating, derived from nanocellulose coated with CaCO 3 particles is constructed via chemical vapor deposition (CVD) for the first time for the preservation of historic paper. The static contact angle of superhydrophobic paper reached more than 150° and the minimum sliding angle was 6.4°. Deacidification effect was achieved with a desired pH value in the range from 7.50 to 7.77 and the maximum alkali storage was up to 1.235 mol/kg. It is found that the low-cost CaCO 3 nanoparticles can not only remove the acid substances, but also gave the paper function of self-cleaning, which is very great significant for the protection of paper-based relics., (Copyright © 2022 Elsevier B.V. All rights reserved.)

As a new and green type of nanomaterials, lignin nanoparticles (LNPs) have been considered as high-value renewable materials for application in many fields. However, the industrialization of LNPs faces many challenges, such as high manufacturing costs and small-scale production. Here, a simple but rapid and reversible approach for the fabrication of LNPs was provided via switching pH environments. The LNPs were regularly shaped in the acetonitrile/water system, and their size appeared to be very homogeneous. The alternation of forming and dissolving of LNPs could be repeated many times simply by alternately adding acid and alkaline solutions. There was little difference in the molecular structures between the original and regenerated LNPs. In addition, the consumption of solvents for LNPs production was only 200 mL g -1 , reduced by more than 10 times compared with conventional solvent exchange methods. The concentration of LNPs in the solution also improved to 5.0 g L -1 . This study not only provides a new, simple, and effective strategy for the fabrication of LNPs but also paves the way towards their real green production and application., (© 2022 Wiley-VCH GmbH.)

In the present work, cellulose nanocrystals (CNCs) composite films with suitable applicable capabilities were prepared by facilely incorporating glycerol (Gly) and poly(benzyl acrylate) (PBA). Chemical and morphological variations during the fabrication of the films were systematically characterized. The properties of modified CNCs composite films including UV blocking ability, mechanical strength and thermal properties were characterized to assess their applicable potentials. As a result, the composite films have good UV shielding property in UVC (220-280 nm) region and UVB (280-320 nm) region. The shielding performance of the modified film in the ultraviolet absorption region reached 92.77% to 95.49% respectively, without damaging the original chiral nematic structure of the films. Along with the modification, BACNC film improved the mechanical properties, presenting the tensile strength 16 times higher compared to pure CNCs film. The nanocomposite films proposed in this work showed promising potentials in broad fields, such as food preservation, medical protection, and surface coating applications., (Copyright © 2022 Elsevier B.V. All rights reserved.)