Search

Your search keyword '"Schuepbach, Reto"' showing total 257 results
Start Over Author "Schuepbach, Reto" Search Limiters Peer Reviewed Publication Type Academic Journals
257 results on '"Schuepbach, Reto"'

2. Reduced anticoagulation strategy is associated with a lower incidence of intracerebral hemorrhage in COVID-19 patients on extracorporeal membrane oxygenation

Author

Hofmaenner, Daniel A., Furfaro, David, Wild, Lennart C., Wendel-Garcia, Pedro David, Baedorf Kassis, Elias, Pannu, Ameeka, Welte, Tobias, Erlebach, Rolf, Stahl, Klaus, Grandin, Edward Wilson, Putensen, Christian, Schuepbach, Reto A., Shaefi, Shahzad, David, Sascha, Seeliger, Benjamin, and Bode, Christian

Published
2023
Full Text
View/download PDF

3. POStoperative INTELLiVENT-adaptive support VEntilation in cardiac surgery patients (POSITiVE) II—study protocol of a randomized clinical trial

Author

Bernardi, Martin H., Bettex, Dominique, Buiteman–Kruizinga, Laura A., de Bie, Ashley, Hoffmann, Matthias, de Kleijn, Janine, Serafini, Simon Corrado, Molenaar, Manon A., Paulus, Frederique, Peršec, Jasminka, Neto, Ary Serpa, Schuepbach, Reto, Severgnini, Paolo, Šribar, Andrej, Schultz, Marcus J., and Tschernko, Edda

Published
2024
Full Text
View/download PDF

9. Machine learning using the extreme gradient boosting (XGBoost) algorithm predicts 5-day delta of SOFA score at ICU admission in COVID-19 patients

Author

Alfaro-Farias, Mario, Vizmanos-Lamotte, Gerardo, Tschoellitsch, Thomas, Meier, Jens, Aguirre-Bermeo, Hernán, Apolo, Janina, Martínez, Alberto, Jurkolow, Geoffrey, Delahaye, Gauthier, Novy, Emmanuel, Losser, Marie-Reine, Wengenmayer, Tobias, Rilinger, Jonathan, Staudacher, Dawid L., David, Sascha, Welte, Tobias, Stahl, Klaus, Pavlos”, “Agios, Aslanidis, Theodoros, Korsos, Anita, Babik, Barna, Nikandish, Reza, Rezoagli, Emanuele, Giacomini, Matteo, Nova, Alice, Fogagnolo, Alberto, Spadaro, Savino, Ceriani, Roberto, Murrone, Martina, Wu, Maddalena A., Cogliati, Chiara, Colombo, Riccardo, Catena, Emanuele, Turrini, Fabrizio, Simonini, Maria Sole, Fabbri, Silvia, Potalivo, Antonella, Facondini, Francesca, Gangitano, Gianfilippo, Perin, Tiziana, Grazia Bocci, Maria, Antonelli, Massimo, Gommers, Diederik, Rodríguez-García, Raquel, Gámez-Zapata, Jorge, Taboada-Fraga, Xiana, Castro, Pedro, Tellez, Adrian, Lander-Azcona, Arantxa, Escós-Orta, Jesús, Martín-Delgado, Maria C., Algaba-Calderon, Angela, Franch-Llasat, Diego, Roche-Campo, Ferran, Lozano-Gómez, Herminia, Zalba-Etayo, Begoña, Michot, Marc P., Klarer, Alexander, Ensner, Rolf, Schott, Peter, Urech, Severin, Zellweger, Nuria, Merki, Lukas, Lambert, Adriana, Laube, Marcus, Jeitziner, Marie M., Jenni-Moser, Beatrice, Wiegand, Jan, Yuen, Bernd, Lienhardt-Nobbe, Barbara, Westphalen, Andrea, Salomon, Petra, Drvaric, Iris, Hillgaertner, Frank, Sieber, Marianne, Dullenkopf, Alexander, Petersen, Lina, Chau, Ivan, Ksouri, Hatem, Sridharan, Govind Oliver, Cereghetti, Sara, Boroli, Filippo, Pugin, Jerome, Grazioli, Serge, Rimensberger, Peter C., Bürkle, Christian, Marrel, Julien, Brenni, Mirko, Fleisch, Isabelle, Lavanchy, Jerome, Perez, Marie-Helene, Ramelet, Anne-Sylvie, Weber, Anja Baltussen, Gerecke, Peter, Christ, Andreas, Ceruti, Samuele, Glotta, Andrea, Marquardt, Katharina, Shaikh, Karim, Hübner, Tobias, Neff, Thomas, Redecker, Hermann, Moret-Bochatay, Mallory, Bentrup, FriederikeMeyer zu, Studhalter, Michael, Stephan, Michael, Brem, Jan, Gehring, Nadine, Selz, Daniela, Naon, Didier, Kleger, Gian-Reto, Pietsch, Urs, Filipovic, Miodrag, Ristic, Anette, Sepulcri, Michael, Heise, Antje, Franchitti Laurent, Marilene, Laurent, Jean-Christophe, Wendel Garcia, Pedro D., Schuepbach, Reto, Heuberger, Dorothea, Bühler, Philipp, Brugger, Silvio, Fodor, Patricia, Locher, Pascal, Camen, Giovanni, Gaspert, Tomislav, Jovic, Marija, Haberthuer, Christoph, Lussman, Roger F., Colak, Elif, Montomoli, Jonathan, Romeo, Luca, Moccia, Sara, Bernardini, Michele, Migliorelli, Lucia, Berardini, Daniele, Donati, Abele, Carsetti, Andrea, Bocci, Maria Grazia, Wendel Garcia, Pedro David, Fumeaux, Thierry, Guerci, Philippe, Schüpbach, Reto Andreas, Ince, Can, Frontoni, Emanuele, and Hilty, Matthias Peter

Published
2021
Full Text
View/download PDF

10. mRNA-based SARS-CoV-2 vaccination is associated with reduced ICU admission rate and disease severity in critically ill COVID-19 patients treated in Switzerland

Author

Hilty, Matthias Peter, Keiser, Stefanie, Wendel Garcia, Pedro D., Moser, André, Schuepbach, Reto A., Hilty, Matthias P., and Schüpbach, Reto A.

Subjects
Vaccination, Messenger RNA, Health care industry
Abstract

Author(s): Matthias Peter Hilty [sup.1], Stefanie Keiser [sup.1], Pedro D. Wendel Garcia [sup.1], André Moser [sup.2], Reto A. Schuepbach [sup.1], Matthias P. Hilty, Reto A. Schüpbach, Pedro D. Wendel Garcia, [...]

Published
2022
Full Text
View/download PDF

11. Dynamics of disease characteristics and clinical management of critically ill COVID-19 patients over the time course of the pandemic: an analysis of the prospective, international, multicentre RISC-19-ICU registry

Author

Wendel-Garcia, Pedro David, Moser, André, Jeitziner, Marie-Madlen, Aguirre-Bermeo, Hernán, Arias-Sanchez, Pedro, Apolo, Janina, Roche-Campo, Ferran, Franch-Llasat, Diego, Kleger, Gian-Reto, Schrag, Claudia, Pietsch, Urs, Filipovic, Miodrag, David, Sascha, Stahl, Klaus, Bouaoud, Souad, Ouyahia, Amel, Fodor, Patricia, Locher, Pascal, Siegemund, Martin, Zellweger, Nuria, Cereghetti, Sara, Schott, Peter, Gangitano, Gianfilippo, Wu, Maddalena Alessandra, Alfaro-Farias, Mario, Vizmanos-Lamotte, Gerardo, Ksouri, Hatem, Gehring, Nadine, Rezoagli, Emanuele, Turrini, Fabrizio, Lozano-Gómez, Herminia, Carsetti, Andrea, Rodríguez-García, Raquel, Yuen, Bernd, Weber, Anja Baltussen, Castro, Pedro, Escos-Orta, Jesus Oscar, Dullenkopf, Alexander, Martín-Delgado, Maria C., Aslanidis, Theodoros, Perez, Marie-Helene, Hillgaertner, Frank, Ceruti, Samuele, Franchitti Laurent, Marilene, Marrel, Julien, Colombo, Riccardo, Laube, Marcus, Fogagnolo, Alberto, Studhalter, Michael, Wengenmayer, Tobias, Gamberini, Emiliano, Buerkle, Christian, Buehler, Philipp K., Keiser, Stefanie, Elhadi, Muhammed, Montomoli, Jonathan, Guerci, Philippe, Fumeaux, Thierry, Schuepbach, Reto A., Jakob, Stephan M., Que, Yok-Ai, and Hilty, Matthias Peter

Published
2022
Full Text
View/download PDF

14. Development and validation of a prognostic model for the early identification of COVID-19 patients at risk of developing common long COVID symptoms

Author

Deforth, Manja, Gebhard, Caroline E., Bengs, Susan, Buehler, Philipp K., Schuepbach, Reto A., Zinkernagel, Annelies S., Brugger, Silvio D., Acevedo, Claudio T., Patriki, Dimitri, Wiggli, Benedikt, Twerenbold, Raphael, Kuster, Gabriela M., Pargger, Hans, Schefold, Joerg C., Spinetti, Thibaud, Wendel-Garcia, Pedro D., Hofmaenner, Daniel A., Gysi, Bianca, Siegemund, Martin, Heinze, Georg, Regitz-Zagrosek, Vera, Gebhard, Catherine, and Held, Ulrike

Published
2022
Full Text
View/download PDF

16. Molecular reprogramming and phenotype switching in Staphylococcus aureus lead to high antibiotic persistence and affect therapy success

Author

Huemer, Markus, Shambat, Srikanth Mairpady, Bergada-Pijuan, Judith, Söderholm, Sandra, Boumasmoud, Mathilde, Vulin, Clément, Gómez-Mejia, Alejandro, Varela, Minia Antelo, Tripathi, Vishwachi, Götschi, Sandra, Maggio, Ewerton Marques, Hasse, Barbara, Brugger, Silvio D., Bumann, Dirk, Schuepbach, Reto A., and Zinkernagel, Annelies S.

Published
2021

18. Intracranial Hemorrhages on Extracorporeal Membrane Oxygenation: Differences Between COVID-19 and Other Viral Acute Respiratory Distress Syndrome

Author

Seeliger, Benjamin, Doebler, Michael, Hofmaenner, Daniel Andrea, Wendel-Garcia, Pedro D., Schuepbach, Reto A., Schmidt, Julius J., Welte, Tobias, Hoeper, Marius M., Gillmann, Hans-Jörg, Kuehn, Christian, Ehrentraut, Stefan Felix, Schewe, Jens-Christian, Putensen, Christian, Stahl, Klaus, Bode, Christian, and David, Sascha

Published
2022
Full Text
View/download PDF

19. Prognostic factors associated with mortality risk and disease progression in 639 critically ill patients with COVID-19 in Europe: Initial report of the international RISC-19-ICU prospective observational cohort

Author

Alfaro Farias, Mario, Margarit, Antoni, Vizmanos-Lamotte, Gerardo, Tschoellitsch, Thomas, Meier, Jens, Cardona, Francesco S., Skola, Josef, Horakova, Lenka, Aguirre-Bermeo, Hernan, Apolo, Janina, Novy, Emmanuel, Losser, Marie-Reine, Jurkolow, Geoffrey, Delahaye, Gauthier, David, Sascha, Welte, Tobias, Wengenmayer, Tobias, Staudacher, Dawid L., Aslanidis, Theodoros, Babik, Barna, Korsos, Anita, Gal, Janos, Csaba, Hermann, Donati, Abele, Carsetti, Andrea, Turrini, Fabrizio, Simonini, Maria Sole, Ceriani, Roberto, Murrone, Martina, Rezoagli, Emanuele, Vitale, Giovanni, Fogagnolo, Alberto, Spadaro, Savino, Wu, Maddalena Alessandra, Cogliati, Chiara, Colombo, Riccardo, Catena, Emanuele, Facondini, Francesca, Potalivo, Antonella, Gangitano, Gianfilippo, Perin, Tiziana, Bocci, Maria Grazia, Antonelli, Massimo, Gommers, Diederik, Ince, Can, Mayor-Vázquez, Eric, Cruz, Maria, Delgado, Martin, Garcia, Raquel Rodriguez, Gamez Zapata, Jorge, Zalba-Etayo, Begoña, Lozano-Gomez, Herminia, Castro, Pedro, Tellez, Adrian, Jacas, Adriana, Muñoz, Guido, Andrea, Rut, Ortiz, Jose, Quintana, Eduard, Rovira, Irene, Reverter, Enric, Fernandez, Javier, Ferrer, Miquel, Badia, Joan R., Lander Azcona, Arantxa, Orta, Jesus Escos, Bühler, Philipp, Brugger, Silvio, Hofmaenner, Daniel, Unseld, Simone, Ruschitzka, Frank, Moret-Bochatay, Mallory, Yuen, Bernd, Hillermann, Thomas, Ksouri, Hatem, Sridharan, Govind Oliver, Ristic, Anette, Sepulcri, Michael, Filipovic, Miodrag, Pietsch, Urs, Salomon, Petra, Drvaric, Iris, Schott, Peter, Urech, Severin, Lambert, Adriana, Merki, Lukas, Laube, Marcus, Hillgaertner, Frank, Sieber, Marianne, Dullenkopf, Alexander, Petersen, Lina, Grazioli, Serge, Rimensberger, Peter C., Fleisch, Isabelle, Lavanchy, Jerome, Marquardt, Katharina, Shaikh, Karim, Redecker, Hermann, Stephan, Michael, Brem, Jan, Rogdo, Bjarte, Birkenmaier, Andre, Meyer zu Bentrup, Friederike, Fodor, Patricia, Locher, Pascal, Camen, Giovanni, Siegemund, Martin, Zellweger, Nuria, Jeitziner, Marie-Madlen, Jenni-Moser, Beatrice, Bürkle, Christian, Kleger, Gian-Reto, Franchitti Laurent, Marilene, Laurent, Jean-Christophe, Gaspert, Tomislav, Jovic, Marija, Studhalter, Michael, Haberthuer, Christoph, Lussman, Roger F., Selz, Daniela, Naon, Didier, Mauri, Romano, Ceruti, Samuele, Marrel, Julien, Brenni, Mirko, Ensner, Rolf, Gehring, Nadine, Heise, Antje, Huebner, Tobias, Neff, Thomas A., Cereghetti, Sara, Boroli, Filippo, Pugin, Jerome, Marczin, Nandor, Wong, Joyce, Wendel Garcia, Pedro David, Fumeaux, Thierry, Guerci, Philippe, Heuberger, Dorothea Monika, Montomoli, Jonathan, Roche-Campo, Ferran, Schuepbach, Reto Andreas, and Hilty, Matthias Peter

Published
2020
Full Text
View/download PDF

20. Former smoking, but not active smoking, is associated with delirium in postoperative ICU patients: a matched case-control study.

Author

Komninou, Maria Angeliki, Egli, Simon, Rossi, Aurelio, Ernst, Jutta, Krauthammer, Michael, Schuepbach, Reto A., Delgado, Marcos, and Bartussek, Jan

Subjects
NICOTINE replacement therapy, DELIRIUM, SURGICAL intensive care, CASE-control method, SMOKING, LOGISTIC regression analysis, INTENSIVE care units, INHALATION injuries
Abstract

Objective: To examine the relationship between current and former smoking and the occurrence of delirium in surgical Intensive Care Unit (ICU) patients. Methods: We conducted a single center, case-control study involving 244 delirious and 251 non-delirious patients that were admitted to our ICU between 2018 and 2022. Using propensity score analysis, we obtained 115 pairs of delirious and non-delirious patients matched for age and Simplified Acute Physiology Score II (SAPS II). Both groups of patients were further stratified into non-smokers, active smokers and former smokers, and logistic regression was performed to further investigate potential confounders. Results: Our study revealed a significant association between former smoking and the incidence of delirium in ICU patients, both in unmatched (adjusted odds ratio (OR): 1.82, 95% confidence interval (CI): 1.17-2.83) and matched cohorts (OR: 3.0, CI: 1.53-5.89). Active smoking did not demonstrate a significant difference in delirium incidence compared to non-smokers (unmatched OR = 0.98, CI: 0.62-1.53, matched OR = 1.05, CI: 0.55-2.0). Logistic regression analysis of the matched group confirmed former smoking as an independent risk factor for delirium, irrespective of other variables like surgical history (p = 0.010). Notably, also respiratory and vascular surgeries were associated with increased odds of delirium (respiratory: OR: 4.13, CI: 1.73-9.83; vascular: OR: 2.18, CI: 1.03-4.59). Medication analysis showed that while Ketamine and Midazolam usage did not significantly correlate with delirium, Morphine use was linked to a decreased likelihood (OR: 0.27, 95% CI: 0.13-0.55). Discussion: Nicotine's complex neuropharmacological impact on the brain is still not fully understood, especially its short-term and long-term implications for critically ill patients. Although our retrospective study cannot establish causality, our findings suggest that smoking may induce structural changes in the brain, potentially heightening the risk of postoperative delirium. Intriguingly, this effect seems to be obscured in active smokers, potentially due to the recognized neuroprotective properties of nicotine. Our results motivate future prospective studies, the results of which hold the potential to substantially impact risk assessment procedures for surgeries. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

23. Impact of sex and gender on post-COVID-19 syndrome, Switzerland, 2020.

Author

Gebhard, Caroline E., Sütsch, Claudia, Gebert, Pimrapat, Gysi, Bianca, Bengs, Susan, Todorov, Atanas, Deforth, Manja, Buehler, Philipp K., Meisel, Alexander, Schuepbach, Reto A., Zinkernagel, Annelies S., Brugger, Silvio D., Acevedo, Claudio, Patriki, Dimitri, Wiggli, Benedikt, Beer, Jürg H., Friedl, Andrée, Twerenbold, Raphael, Kuster, Gabriela M., and Pargger, Hans

Published
2024
Full Text
View/download PDF

25. Quantification of within-patient Staphylococcus aureus phenotypic heterogeneity as a proxy for the presence of persisters across clinical presentations

Author

Bär, Julian, Boumasmoud, Mathilde, Mairpady Shambat, Srikanth, Vulin, Clément, Huemer, Markus, Schweizer, Tiziano A., Gómez-Mejia, Alejandro, Eberhard, Nadia, Achermann, Yvonne, Zingg, Patrick O., Mestres, Carlos A., Brugger, Silvio D., Schuepbach, Reto A., Kouyos, Roger D., Hasse, Barbara, and Zinkernagel, Annelies S.

Published
2022
Full Text
View/download PDF

34. The phenomenon of desorption: What are the best adsorber exchange intervals?

Author

Buhlmann, Alix, Erlebach, Rolf, Müller, Mattia, David, Sascha, Kleinert, Eva-Maria, Andermatt, Rea, Hofmaenner, Daniel Andrea, Mueller, Mattia, Schuepbach, Reto, Wendel-Garcia, Pedro David, Ganter, Christoph Camille, Stahl, Klaus, Welte, Tobias, Pape, Thorben, Rath, Ann-Kathrin, Nalbant, Bahar, Ruwisch, Jannik, Bode, Christian, Seeliger, Benjamin, and Putensen, Christian

Published
2024
Full Text
View/download PDF

35. Indications and Outcomes of Patients Receiving Therapeutic Plasma Exchange under Critical Care Conditions: A Retrospective Eleven-Year Single-Center Study at a Tertiary Care Center.

Author

Ring, Alexander, Sieber, Wolfgang Alexander, Studt, Jan-Dirk, Schuepbach, Reto A., Ganter, Christoph Camille, Manz, Markus Gabriel, Müller, Antonia Maria Susanne, and David, Sascha

Subjects
PLASMA exchange (Therapeutics), CRITICAL care medicine, TERTIARY care, RENAL replacement therapy, INTENSIVE care units
Abstract

Background: Therapeutic plasma exchange (TPE) is frequently performed in critical care settings for heterogenous indications. However, specific intensive care unit (ICU) data regarding TPE indications, patient characteristics and technical details are sparse. Methods: We performed a retrospective, single-center study using data from January 2010 until August 2021 for patients treated with TPE in an ICU setting at the University Hospital Zurich. Data collected included patient characteristics and outcomes, ICU-specific parameters, as well as apheresis-specific technical parameters and complications. Results: We identified n = 105 patients receiving n = 408 TPEs for n = 24 indications during the study period. The most common was thrombotic microangiopathies (TMA) (38%), transplant-associated complications (16.3%) and vasculitis (14%). One-third of indications (35.2%) could not be classified according to ASFA. Anaphylaxis was the most common TPE-related complication (6.7%), while bleeding complications were rare (1%). The median duration of ICU stay was 8 ± 14 days. Ventilator support, renal replacement therapy or vasopressors were required in 59 (56.2%), 26 (24.8%), and 35 (33.3%) patients, respectively, and 6 (5.7%) patients required extracorporeal membrane oxygenation. The overall hospital survival rate was 88.6%. Conclusion: Our study provides valuable real-world data on heterogenous TPE indications for patients in the ICU setting, potentially supporting decision-making. [ABSTRACT FROM AUTHOR]

Published
2023
Full Text
View/download PDF

36. EXCHANGE-2: investigating the efficacy of add-on plasma exchange as an adjunctive strategy against septic shock—a study protocol for a randomized, prospective, multicenter, open-label, controlled, parallel-group trial.

Author

David, Sascha, Bode, Christian, Stahl, Klaus, Schmidt, Julius, Seeliger, Benjamin, Pape, Thorben, Schmidt, Bernhard, Hoeper, Marius M., Wedemeyer, Heiner, Welte, Tobias, Schmidt-Ott, Kai, Wendel Garcia, Pedro David, Hofmänner, Daniel A., Andermatt, Rea, Schuepbach, Reto, Bankova, Andriyana, Gillmann, Hans-Joerg, Stueber, Thomas, Jung, Carolin, and Gerdes, Andre

Subjects
SEPTIC shock, PLASMA exchange (Therapeutics), BLOOD volume, RESEARCH protocols, PLASMA products, CLINICAL trials
Abstract

Background: Sepsis is as a life-threatening organ dysfunction caused by a dysregulated host response to an infection. The mortality of sepsis and particular of septic shock is very high. Treatment mostly focuses on infection control but a specific intervention that targets the underlying pathological host response is lacking to the present time. The investigators hypothesize that early therapeutic plasma exchange (TPE) will dampen the maladaptive host response by removing injurious mediators thereby limiting organ dysfunction and improving survival in patients with septic shock. Although small prospective studies demonstrated rapid hemodynamic stabilization under TPE, no adequately powered randomized clinical trial has investigated hard outcomes. Methods: This is a randomized, prospective, multicenter, open-label, controlled, parallel-group interventional trial to test the adjunctive effect of TPE in patients with early septic shock. Patients with a refractory (defined as norepinephrine (NE) ≥ 0.4 μg/kg/min ≥ 30 min OR NE 0.3 μg/kg/min + vasopressin) and early (shock onset < 24 h) septic shock will be included. The intervention is a standard TPE with donor fresh frozen plasma (1.2 × individual plasma volume) performed within 6 h after randomization and will be compared to a standard of care (SOC) control arm. The primary endpoint is 28 days mortality for which the power analysis revealed a group size of 137 / arm (n = 274) to demonstrate a benefit of 15%. The key secondary objective will be to compare the extent of organ failure indicated by mean SOFA over the first 7 days as well as organ support-free days until day 28 following randomization. Besides numerous biological secondary, safety endpoints such as incidence of bleeding, allergic reactions, transfusion associated lung injury, severe thrombocytopenia, and other severe adverse events will be assessed during the first 7 days. For exploratory scientific analyses, biomaterial will be acquired longitudinally and multiple predefined scientific subprojects are planned. This study is an investigator-initiated trial supported by the German Research Foundation (DFG, DA 1209/7–1), in which 26 different centers in Germany, Switzerland, and Austria will participate over a duration of 33 months. Discussion: This trial has substantial clinical relevance as it evaluates a promising adjunctive treatment option in refractory septic shock patients suffering from an extraordinary high mortality. A positive trial result could change the current standard of care for this septic subgroup. The results of this study will be disseminated through presentations at international congresses, workshops, and peer-reviewed publications. Trial registration: ClinicalTrials.gov NCT05726825, Registered on 14 February 2023. [ABSTRACT FROM AUTHOR]

Published
2023
Full Text
View/download PDF

37. Effects of tall man lettering on the visual behaviour of critical care nurses while identifying syringe drug labels: a randomised in situ simulation.

Author

Lohmeyer, Quentin, Schiess, Cornel, Garcia, Pedro David Wendel, Petry, Heidi, Strauch, Eric, Dietsche, Andreas, Schuepbach, Reto A., Buehler, Philipp K., and Hofmaenner, Daniel A.

Subjects
MEDICATION error prevention, INTENSIVE care units, SYRINGES, INTENSIVE care nursing, ACADEMIC medical centers, CONFIDENCE intervals, SIMULATION methods in education, CRITICAL care nurses, RANDOMIZED controlled trials, EYE movement measurements, DRUG labeling, ATTENTION, QUESTIONNAIRES, DESCRIPTIVE statistics, STATISTICAL models, STATISTICAL sampling, DATA analysis software, EDUCATIONAL outcomes, LONGITUDINAL method
Abstract

Background Patients in intensive care units are prone to the occurrence of medication errors. Look-alike, sound-alike drugs with similar drug names can lead to medication errors and therefore endanger patient safety. Capitalisation of distinct text parts in drug names might facilitate differentiation of medication labels. The aim of this study was to test whether the use of such 'tall man' lettering (TML) reduces the error rate and to examine effects on the visual attention of critical care nurses while identifying syringe labels. Methods This was a prospective, randomised in situ simulation conducted at the University Hospital Zurich, Zurich, Switzerland. Under observation by eye tracking, 30 nurses were given 10 successive tasks involving the presentation of a drug name and its selection from a dedicated set of 10 labelled syringes that included look-alike and sound-alike drug names, half of which had TML-coded labels. Error rate as well as dwell time, fixation count, fixation duration and revisits were analysed using a linear mixed-effects model analysis to compare TML-coded with non-TML-coded labels. Results TML coding of syringe labels led to a significant decrease in the error rate (from 5.3% (8 of 150 in non-TML-coded sets) to 0.7% (1 of 150 in TML-coded sets), p<0.05). Eye tracking further showed that TML affects visual attention, resulting in longer dwell time (p<0.01), more and longer fixations (p<0.05 and p<0.01, respectively) on the drug name as well as more frequent revisits (p<0.01) compared with non-TML-coded labels. Detailed analysis revealed that these effects were stronger for labels using TML in the mid-to-end position of the drug name. Conclusions TML in drug names changes visual attention while identifying syringe labels and supports critical care nurses in preventing medication errors. [ABSTRACT FROM AUTHOR]

Published
2023
Full Text
View/download PDF

38. Sex versus gender-related characteristics: which predicts clinical outcomes of acute COVID-19?

Author

Gebhard, Caroline E., Hamouda, Nadia, Gebert, Pimrapat, Regitz-Zagrosek, Vera, Gebhard, Catherine, on behalf of the COGEN Investigators, Bengs, Susan, Gysi, Bianca, Dussault-Cloutier, Arnaud, Buehler, Karl Philipp, Schuepbach, Reto A., Zinkernagel, Annelies S., Brugger, Silvio D., Acevedo, Claudio, Patriki, Dimitri, Wiggli, Benedikt, Beer, Jürg H., Friedl, Andrée, Twerenbold, Raphael, and Kuster, Gabriela M.

Published
2022
Full Text
View/download PDF

40. High-Affinity Cu(I)-Chelator with Potential Anti-Tumorigenic Action—A Proof-of-Principle Experimental Study of Human H460 Tumors in the CAM Assay.

Author

Heuberger, Dorothea M., Wolint, Petra, Jang, Jae-Hwi, Itani, Saria, Jungraithmayr, Wolfgang, Waschkies, Conny F., Meier-Bürgisser, Gabriella, Andreoli, Stefano, Spanaus, Katharina, Schuepbach, Reto A., Calcagni, Maurizio, Fahrni, Christoph J., and Buschmann, Johanna

Subjects
TREATMENT of lung tumors, COPPER metabolism, EXPERIMENTAL design, CHELATION therapy, ANALYSIS of variance, IMMUNOHISTOCHEMISTRY, CELL physiology, CELL receptors, FISHER exact test, CELL survival, DESCRIPTIVE statistics, PATHOLOGIC neovascularization, BIOLOGICAL assay, DATA analysis software
Abstract

Simple Summary: Lung cancer is a serious burden worldwide. The growth of lung tumors depends on vessel density and intratumoral copper concentration. Copper chelating agents can reduce copper content in tumor tissue, resulting in lower vessel density and lower tumor weight. PSP-2, a very potent copper chelator, was tested on lung tumor grafts that were on-planted on the chorioallantoic membrane of the chicken embryo. We found a lower vessel density and a lower tumor weight under PSP-2 application compared to the controls. Thus, PSP-2 could be a potential therapeutic agent to treat lung cancer in the future. Human lung cancer ranks among the most frequently treated cancers worldwide. As copper appears critical to angiogenesis and tumor growth, selective removal of copper represents a promising strategy to restrict tumor growth. To this end, we explored the activity of the novel high-affinity membrane-permeant Cu(I) chelator PSP-2 featuring a low-zeptomolar dissociation constant. Using H460 human lung cancer cells, we generated small tumors on the chorioallantoic membrane of the chicken embryo (CAM assay) and studied the effects of topical PSP-2 application on their weight and vessel density after one week. We observed a significant angiosuppression along with a marked decrease in tumor weight under PSP-2 application compared to controls. Moreover, PSP-2 exposure resulted in lower ki67+ cell numbers at a low dose but increased cell count under a high dose. Moreover, HIF-1α+ cells were significantly reduced with low-dose PSP-2 exposure compared to high-dose and control. The total copper content was considerably lower in PSP-2 treated tumors, although statistically not significant. Altogether, PSP-2 shows promising potential as an anti-cancer drug. Nevertheless, further animal experiments and application to different tumor types are mandatory to support these initial findings, paving the way toward clinical trials. [ABSTRACT FROM AUTHOR]

Published
2022
Full Text
View/download PDF

41. Renal Tubular Acidosis in Pregnant Critically Ill COVID-19 Patients: A Secondary Analysis of a Prospective Cohort.

Author

Humbel, Simona, Wendel-Garcia, Pedro David, Unseld, Simone, Noll, Fabienne, Schuepbach, Reto Andreas, Ganter, Christoph Camille, Seeger, Harald, David, Sascha, and Andermatt, Rea

Subjects
COVID-19, RENAL tubular transport disorders, CRITICALLY ill, SECONDARY analysis, ACIDOSIS, INTENSIVE care units
Abstract

Background: Renal tubular acidosis (RTA) is an extremely rare cause of metabolic acidosis (10 in 100,000). RTA has been linked neither to pregnancy nor to severe coronavirus disease 2019 (COVID-19). The purpose of this study was to analyze the prevalence and clinical course of normal anion gap metabolic acidosis in critically ill pregnant COVID-19 patients and to compare them to an age-matched nonpregnant female patient cohort. Methods: Secondary analysis was conducted on a prospective observational cohort of critically ill patients suffering from COVID-19 consecutively admitted to a tertiary intensive care unit (ICU) between February 2020 and April 2021. Results: A total of 321 COVID-19 patients required admission to the ICU; 95 (30%) were female, and 18 (19%) were of childbearing age. Seven of eight (88%) pregnant women (all in the last trimester) required advanced respiratory support due to COVID-19. The estimated glomerular filtration rate was 135 (123–158) mL/min/m2 body surface area, and six pregnant women (86%) were diagnosed with a normal, respiratory compensated, anion gap metabolic acidosis (pHmin 7.3 (7.18–7.31), HCO3−min 14.8 (12.8–18.6) mmol/L, and paCO2 3.4 (3.3–4.5) kPa). Three (43%) acidotic pregnant women fulfilled diagnostic criteria for RTA. All women recovered spontaneously within less 7 days. Conclusions: Metabolic acidosis seems to be very common (85%) in pregnant critically ill COVID-19 patients, and the prevalence of RTA might be higher than normal. It remains to be demonstrated if this observation is an indirect epiphenomenon or due to a direct viral effect on the tubular epithelium. [ABSTRACT FROM AUTHOR]

Published
2022
Full Text
View/download PDF

45. Critically ill COVID-19 patients with neutralizing autoantibodies against type I interferons have increased risk of herpesvirus disease.

Author

Busnadiego, Idoia, Abela, Irene A., Frey, Pascal M., Hofmaenner, Daniel A., Scheier, Thomas C., Schuepbach, Reto A., Buehler, Philipp K., Brugger, Silvio D., and Hale, Benjamin G.

Subjects
AUTOANTIBODIES, IMMUNOGLOBULIN M, TYPE I interferons, HERPESVIRUS diseases, SARS-CoV-2, COVID-19, HUMAN herpesvirus 1
Abstract

Autoantibodies neutralizing the antiviral action of type I interferons (IFNs) have been associated with predisposition to severe Coronavirus Disease 2019 (COVID-19). Here, we screened for such autoantibodies in 103 critically ill COVID-19 patients in a tertiary intensive care unit (ICU) in Switzerland. Eleven patients (10.7%), but no healthy donors, had neutralizing anti-IFNα or anti-IFNα/anti-IFNω IgG in plasma/serum, but anti-IFN IgM or IgA was rare. One patient had nonneutralizing anti-IFNα IgG. Strikingly, all patients with plasma anti-IFNα IgG also had anti-IFNα IgG in tracheobronchial secretions, identifying these autoantibodies at anatomical sites relevant for Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection. Longitudinal analyses revealed patient heterogeneity in terms of increasing, decreasing, or stable anti-IFN IgG levels throughout the length of hospitalization. Notably, presence of anti-IFN autoantibodies in this critically ill COVID-19 cohort appeared to predict herpesvirus disease (caused by herpes simplex viruses types 1 and 2 (HSV-1/-2) and/or cytomegalovirus (CMV)), which has been linked to worse clinical outcomes. Indeed, all 7 tested COVID-19 patients with anti-IFN IgG in our cohort (100%) suffered from one or more herpesviruses, and analysis revealed that these patients were more likely to experience CMV than COVID-19 patients without anti-IFN autoantibodies, even when adjusting for age, gender, and systemic steroid treatment (odds ratio (OR) 7.28, 95% confidence interval (CI) 1.14 to 46.31, p = 0.036). As the IFN system deficiency caused by neutralizing anti-IFN autoantibodies likely directly and indirectly exacerbates the likelihood of latent herpesvirus reactivations in critically ill patients, early diagnosis of anti-IFN IgG could be rapidly used to inform risk-group stratification and treatment options. Trial Registration: ClinicalTrials.gov Identifier: NCT04410263. Autoantibodies that neutralize the antiviral action of type I interferons are associated with predisposition to severe COVID-19. This study shows that this deficiency in the interferon system is associated with a heightened risk of herpesvirus disease in critically ill patients infected with SARS-CoV-2. [ABSTRACT FROM AUTHOR]

Published
2022
Full Text
View/download PDF

46. Severe Toxic Epidermal Necrolysis and Drug Reaction with Eosinophilia and Systemic Symptoms Overlap Syndrome Treated with Benralizumab: A Case Report.

Author

Zeller, Felix K., Bader, Patrick R., Nägeli, Mirjam C., Buehler, Philipp K., and Schuepbach, Reto A.

Subjects
TOXIC epidermal necrolysis, CRITICALLY ill patient care, EOSINOPHILIA, INTENSIVE care patients, SYMPTOMS
Abstract

TEN/DRESS overlap syndrome can be difficult to diagnose, especially if it is masked by comorbidities in critically ill patients in intensive care units. The existing therapy for the two conditions is also a major challenge for the treating team. A possible alternative, especially for refractory cases, is benralizumab as an IL-5-receptor alpha-chain-specific humanized monoclonal antibody (IgG1k). We are able to show a successful treatment in this case report. [ABSTRACT FROM AUTHOR]

Published
2022
Full Text
View/download PDF

49. Myocardial edema in COVID-19 on cardiac MRI

Author

Manka, Robert, Karolyi, Mihaly, Polacin, Malgorzata, Holy, Erik W., Nemeth, Johannes, Steiger, Peter, Schuepbach, Reto A., Zinkernagel, Annelies S., Alkadhi, Hatem, Mehra, Mandeep R., and Ruschitzka, Frank

Published
2020
Full Text
View/download PDF

50. Regulation of iron homeostasis by the hypoxia-inducible transcription factors (HIFs)

Author

Peyssonnaux, Carole, Zinkernagel, Annelies S., Schuepbach, Reto A., Rankin, Erinn, Vaulont, Sophie, Haase, Volker H., Nizet, Victor, and Johnson, Randall S.

Subjects
Homeostasis -- Research, Iron in the body -- Physiological aspects, Hypoxia -- Research, DNA binding proteins -- Physiological aspects
Abstract

Iron is essential for many biological processes, including oxygen delivery, and its supply is tightly regulated. Hepcidin, a small peptide synthesized in the liver, is a key regulator of iron [...]

Published
2007

Catalog

Books, media, physical & digital resources
See catalog results