6 results on '"Rene Baudrand"'
Search Results
2. Impact of short and long exposure to cafeteria diet on food intake and white adipose tissue lipolysis mediated by glucagon-like peptide 1 receptor
- Author
-
Pamela Mattar, Cristian Jaque, Jennifer A. Teske, Eugenia Morselli, Bredford Kerr, Víctor Cortés, Rene Baudrand, and Claudio E. Perez-Leighton
- Subjects
obesity ,glucagon-like peptide 1 (GLP-1) ,cafeteria diet ,lipolysis ,white adipose tissue ,Diseases of the endocrine glands. Clinical endocrinology ,RC648-665 - Abstract
IntroductionThe modern food environment facilitates excessive calorie intake, a major driver of obesity. Glucagon-like peptide 1 (GLP1) is a neuroendocrine peptide that has been the basis for developing new pharmacotherapies against obesity. The GLP1 receptor (GLP1R) is expressed in central and peripheral tissues, and activation of GLP1R reduces food intake, increases the expression of thermogenic proteins in brown adipose tissue (BAT), and enhances lipolysis in white adipose tissue (WAT). Obesity decreases the efficiency of GLP1R agonists in reducing food intake and body weight. Still, whether palatable food intake before or during the early development of obesity reduces the effects of GLP1R agonists on food intake and adipose tissue metabolism remains undetermined. Further, whether GLP1R expressed in WAT contributes to these effects is unclear.MethodsFood intake, expression of thermogenic BAT proteins, and WAT lipolysis were measured after central or peripheral administration of Exendin-4 (EX4), a GLP1R agonist, to mice under intermittent-short exposure to CAF diet (3 h/d for 8 days) or a longer-continuous exposure to CAF diet (24 h/d for 15 days). Ex-vivo lipolysis was measured after EX4 exposure to WAT samples from mice fed CAF or control diet for 12 weeks. .ResultsDuring intermittent-short exposure to CAF diet (3 h/d for 8 days), third ventricle injection (ICV) and intra-peritoneal administration of EX4 reduced palatable food intake. Yet, during a longer-continuous exposure to CAF diet (24 h/d for 15 days), only ICV EX4 administration reduced food intake and body weight. However, this exposure to CAF diet blocked the increase in uncoupling protein 1 (UCP1) caused by ICV EX4 administration in mice fed control diet. Finally, GLP1R expression in WAT was minimal, and EX4 failed to increase lipolysis ex-vivo in WAT tissue samples from mice fed CAF or control diet for 12 weeks. .DiscussionExposure to a CAF diet during the early stages of obesity reduces the effects of peripheral and central GLP1R agonists, and WAT does not express a functional GLP1 receptor. These data support that exposure to the obesogenic food environment, without the development or manifestation of obesity, can alter the response to GLP1R agonists. .
- Published
- 2023
- Full Text
- View/download PDF
3. Mineralocorticoid receptor modulation by dietary sodium influences NAFLD development in mice
- Author
-
Daniel Cabrera, Isabel Rao, Fabiola Raasch, Nancy Solis, Margarita Pizarro, Mariela Freire, Diego Sáenz De Urturi, Carolina A. Ramírez, Nicolás Triantafilo, Jonathan León, Arnoldo Riquelme, Francisco Barrera, Rene Baudrand, Patricia Aspichueta, Marco Arrese, and Juan P. Arab
- Subjects
Non-alcoholic fatty liver disease ,NAFLD ,NASH ,Steatohepatitis ,Fatty liver ,Mineralocorticoid receptor ,Specialties of internal medicine ,RC581-951 - Abstract
Introduction and Objectives: Nonalcoholic-fatty-liver disease (NAFLD) is considered the hepatic manifestation of metabolic syndrome (MetS). Mineralocorticoid receptor (MR) activation is associated with increased risk of MetS but few studies have assessed the role of liver MR on NAFLD. We aimed to evaluate the effect of MR modulation by sodium intake in liver injury in experimental models of NAFLD. Materials and Methods: C57BL/6J mice were fed either a high-fat-diet (HFD) or a choline/methionine deficient (MCD) diet with different sodium concentrations. Hepatic concentration of lipid species, serum aldosterone levels, expression of MR, proinflammatory and profibrotic markers and liver histology were assessed. Results: Mice fed with High-Na+/HFD showed a lower MR expression in liver (p = 0.01) and less steatosis on histology (p = 0.04). Consistently, animals from this group exhibited lower levels of serum aldosterone (p = 0.028) and lower hepatic triglyceride content (p = 0.008). This associated to a reduced expression of lipogenic genes, significant changes in lipid subspecies, lower HOMA-IR (p
- Published
- 2021
- Full Text
- View/download PDF
4. Caveolin 1 Modulates Aldosterone‐Mediated Pathways of Glucose and Lipid Homeostasis
- Author
-
Rene Baudrand, Nidhi Gupta, Amanda E. Garza, Anand Vaidya, Jane A. Leopold, Paul N. Hopkins, Xavier Jeunemaitre, Claudio Ferri, Jose R. Romero, Jonathan Williams, Joseph Loscalzo, Gail K. Adler, Gordon H. Williams, and Luminita H. Pojoga
- Subjects
aldosterone ,caveolin 1 ,dyslipidemia ,eplerenone ,insulin resistance ,mineralocorticoid receptor ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
BackgroundOveractivation of the aldosterone and mineralocorticoid receptor (MR) pathway is associated with hyperglycemia and dyslipidemia. Caveolin 1 (cav‐1) is involved in glucose/lipid homeostasis and may modulate MR signaling. We investigated the interplay between cav‐1 and aldosterone signaling in modulating insulin resistance and dyslipidemia in cav‐1–null mice and humans with a prevalent variant in the CAV1 gene. Methods and ResultsIn mouse studies, cav‐1 knockout mice exhibited higher levels of homeostatic model assessment of insulin resistance, cholesterol, and resistin and lower ratios of high‐ to low‐density lipoprotein (all P
- Published
- 2016
- Full Text
- View/download PDF
5. The Low-Renin Hypertension Phenotype: Genetics and the Role of the Mineralocorticoid Receptor
- Author
-
Rene Baudrand and Anand Vaidya
- Subjects
renin ,low-renin ,hypertension ,mineralocorticoid receptor ,genetics ,aldosterone ,Biology (General) ,QH301-705.5 ,Chemistry ,QD1-999 - Abstract
A substantial proportion of patients with hypertension have a low or suppressed renin. This phenotype of low-renin hypertension (LRH) may be the manifestation of inherited genetic syndromes, acquired somatic mutations, or environmental exposures. Activation of the mineralocorticoid receptor is a common final mechanism for the development of LRH. Classically, the individual causes of LRH have been considered to be rare diseases; however, recent advances suggest that there are milder and “non-classical” variants of many LRH-inducing conditions. In this regard, our understanding of the underlying genetics and mechanisms accounting for LRH, and therefore, potentially the pathogenesis of a large subset of essential hypertension, is evolving. This review will discuss the potential causes of LRH, with a focus on implicated genetic mechanisms, the expanding recognition of non-classical variants of conditions that induce LRH, and the role of the mineralocorticoid receptor in determining this phenotype.
- Published
- 2018
- Full Text
- View/download PDF
6. 11β-hydroxysteroid dehydrogenase type-2 and type-1 (11β-HSD2 and 11β-HSD1) and 5β-reductase activities in the pathogenia of essential hypertension.
- Author
-
Carmen Campino, Cristian Carvajal, Javiera Cornejo, Betty Martín, Oliviero Olivieri, Giancesare Guidi, Giovanni Faccini, Francesco Pasini, Javiera Sateler, Rene Baudrand, Lorena Mosso, Gareth Owen, Alexis Kalergis, Oslando Padilla, and Carlos Fardella
- Abstract
Abstract Cortisol availability is modulated by several enzymes: 11β-HSD2, which transforms cortisol (F) to cortisone (E) and 11β-HSD1 which predominantly converts inactive E to active F. Additionally, the A-ring reductases (5α- and 5β-reductase) inactivate cortisol (together with 3α-HSD) to tetrahydrometabolites: 5αTHF, 5βTHF, and THE. The aim was to assess 11β-HSD2, 11β-HSD1, and 5β-reductase activity in hypertensive patients. Free urinary F, E, THF, and THE were measured by HPLC–MS/MS in 102 essential hypertensive patients and 18 normotensive controls. 11β-HSD2 enzyme activity was estimated by the F/E ratio, the activity of 11β-HSD1 in compare to 11β-HSD2 was inferred by the (5αTHF + 5βTHF)/THE ratio and 5β-reductase activity assessed using the E/THE ratio. Activity was considered altered when respective ratios exceeded the maximum value observed in the normotensive controls. A 15.7% of patients presented high F/E ratio suggesting a deficit of 11β-HSD2 activity. Of the remaining 86 hypertensive patients, two possessed high (5αTHF + 5βTHF)/THE ratios and 12.8% had high E/THE ratios. We observed a high percentage of alterations in cortisol metabolism at pre-receptor level in hypertensive patients, previously misclassified as essential. 11β-HSD2 and 5β-reductase decreased activity and imbalance of 11β-HSDs should be considered in the future management of hypertensive patients. [ABSTRACT FROM AUTHOR]
- Published
- 2010
- Full Text
- View/download PDF
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.