1. Statin Users Without an APOE-ℇ4 Allele have Increased Insulin Resistance.
- Author
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VanFossen, Brian T., Watson, G. Stennis, Baker, Laura D., Rhoads, Kristoffer W., Cholerton, Brenna A., Reger, Mark A., Plymate, Stephen R., Schellenberg, Gerald, and Craft, Suzanne
- Subjects
ALZHEIMER'S disease ,STATINS (Cardiovascular agents) ,APOLIPOPROTEIN E ,INSULIN resistance ,HOMEOSTASIS ,DIABETES ,INSULIN - Abstract
The present study examined the relationships among statin use, APOE genotype, and insulin resistance as measured by the homeostasis model assessment of insulin resistance (HOMA-IR) in healthy older adults. APOE ℇ4- (i.e., not having an ℇ4 allele) statin users had higher HOMA-IR values compared with ℇ4+/statin users (p=0.0169), and with non-users who were ℇ4- (p=0.0003) or ℇ4+ (p=0.0006). These results suggest that statin use may modulate insulin levels for individuals without an APOE ℇ4 allele. [ABSTRACT FROM AUTHOR]
- Published
- 2010
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