612 results on '"Spring, David R."'
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2. Towards the Targeted Protein Degradation of PRMT1.
3. Tuneable thiol exchange linkers for traceless drug release applications in prodrugs and ADCs.
4. CK2 Inhibitors Targeting Inside and Outside the Catalytic Box.
5. Photoredox C(2)-Arylation of Indole- and Tryptophan-Containing Biomolecules.
6. Unlocking Amides: A General Method for the Self‐Immolative Release of Amide‐Containing Molecules.
7. Microscopy and chemical analyses reveal flavone-based woolly fibres extrude from micron-sized holes in glandular trichomes of Dionysia tapetodes
8. Energetics of lipid transport by the ABC transporter MsbA is lipid dependent
9. Site-selective peptide functionalisation mediated via vinyl-triazine linchpins.
10. Synthesis of structurally diverse biflavonoids
11. Novel non-ATP competitive small molecules targeting the CK2 α/β interface
12. Finding New Components of the Target of Rapamycin (TOR) Signaling Network through Chemical Genetics and Proteome Chips
13. A fragment-based approach leading to the discovery of a novel binding site and the selective CK2 inhibitor CAM4066
14. A cryptic hydrophobic pocket in the polo-box domain of the polo-like kinase PLK1 regulates substrate recognition and mitotic chromosome segregation
15. A recombinant approach for stapled peptide discovery yields inhibitors of the RAD51 recombinase.
16. A cell-active cyclic peptide targeting the Nrf2/Keap1 protein–protein interaction.
17. Studies Towards the Synthesis of the Core of Endiandric Acid H
18. An expedient strategy for the diversity-oriented synthesis of macrocyclic compounds with natural product-like characteristics
19. Tryptophan in Multicomponent Petasis Reactions for Peptide Stapling and Late‐Stage Functionalisation.
20. Disulfide re-bridging reagents for single-payload antibody-drug conjugates.
21. Divergent and concise total syntheses of dihydrochalcones and 5-deoxyflavones recently isolated from Tacca species and Mimosa diplotricha
22. Overcoming Chemical, Biological, and Computational Challenges in the Development of Inhibitors Targeting Protein-Protein Interactions
23. Studies towards the synthesis of indolizin-5(3H)-one derivatives and related 6,5-azabicyclic scaffolds by ring-closing metathesis
24. Multifunctional supramolecular polymer networks as next-generation consolidants for archaeological wood conservation
25. Synthesis of sp3-rich heterocyclic frameworks by a divergent synthesis strategy.
26. Identification of macrocyclic peptides which activate bacterial cylindrical proteases.
27. Antiplasmodial and trypanocidal activity of violacein and deoxyviolacein produced from synthetic operons
28. Peroxide-cleavable linkers for antibody–drug conjugates.
29. Hybrid Androgen Receptor Inhibitors Outperform Enzalutamide and EPI‐001 in in vitro Models of Prostate Cancer Drug Resistance.
30. A two-component 'double-click' approach to peptide stapling
31. Applications of small molecule activators and inhibitors of quorum sensing in Gram-negative bacteria
32. A quorum-sensing molecule acts as a morphogen controlling gas vesicle organelle biogenesis and adaptive flotation in an enterobacterium
33. Diversity-oriented synthesis of macrocyclic peptidomimetics
34. Variations on a theme: diverse N-acyl homoserine lactone-mediated quorum sensing mechanisms in Gram-negative bacteria
35. Non-internalising antibody–drug conjugates.
36. Antibody dual-functionalisation enabled through a modular divinylpyrimidine disulfide rebridging strategy.
37. All-in-one disulfide bridging enables the generation of antibody conjugates with modular cargo loading.
38. Structure-activity analysis of the Pseudomonas quinolone signal molecule
39. Development of small cyclic peptides targeting the CK2α/β interface.
40. Virulence in Pectobacterium atrosepticum is regulated by a coincidence circuit involving quorum sensing and the stress alarmone, (p)ppGpp
41. Metabolic and regulatory engineering of Serratia marcescens: mimicking phage-mediated horizontal acquisition of antibiotic biosynthesis and quorumsensing capacities
42. Communications blackout? Do N-acylhomoserine-lactone-degrading enzymes have any role in quorum sensing?
43. Divinylpyrimidine reagents generate antibody–drug conjugates with excellent in vivo efficacy and tolerability.
44. Diversity-oriented synthesis of biaryl-containing medium rings using a one bed/one stock solution platform
45. The Serratia LuxR family regulator CarR39006 activates transcription independently of cognate quorum sensing signals
46. Drug discovery: A question of library design: Two approaches have emerged for creating libraries of compounds for use in biological screening assays for drug discovery — fragment-based ligand design and diversity-oriented synthesis. Advocates of each approach discuss their favoured strategy.
47. Engineering of new prodigiosin-based biosensors of Serratia for facile detection of short-chain N-acyl homoserine lactone quorum-sensing molecules
48. Assessment of structural diversity in combinatorial synthesis
49. Synthesis and utilization of functionalized polystyrene resins
50. Targeting a Novel KRAS Binding Site: Application of One-Component Stapling of Small (5–6-mer) Peptides.
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