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IntroductionAlthough frontotemporal dementia (FTD) with right anterior temporal lobe (RATL) predominance has been recognized, a uniform description of the syndrome is still missing. This multicenter study aims to establish a cohesive clinical phenotype.MethodsRetrospective clinical data from 18 centers across 12 countries yielded 360 FTD patients with predominant RATL atrophy through initial neuroimaging assessments.ResultsCommon symptoms included mental rigidity/preoccupations (78%), disinhibition/socially inappropriate behavior (74%), naming/word-finding difficulties (70%), memory deficits (67%), apathy (65%), loss of empathy (65%), and face-recognition deficits (60%). Real-life examples unveiled impairments regarding landmarks, smells, sounds, tastes, and bodily sensations (74%). Cognitive test scores indicated deficits in emotion, people, social interactions, and visual semantics however, lacked objective assessments for mental rigidity and preoccupations.DiscussionThis study cumulates the largest RATL cohort unveiling unique RATL symptoms subdued in prior diagnostic guidelines. Our novel approach, combining real-life examples with cognitive tests, offers clinicians a comprehensive toolkit for managing these patients.HighlightsThis project is the first international collaboration and largest reported cohort. Further efforts are warranted for precise nomenclature reflecting neural mechanisms. Our results will serve as a clinical guideline for early and accurate diagnoses.

The limited temporal completeness and taxonomic accuracy of species lists, made available in a traditional manner in scientific publications, has always represented a problem. These lists are invariably limited to a few taxonomic groups and do not represent up-to-date knowledge of all species and classifications. In this context, the Brazilian megadiverse fauna is no exception, and the Catálogo Taxonômico da Fauna do Brasil (CTFB) (http://fauna.jbrj.gov.br/), made public in 2015, represents a database on biodiversity anchored on a list of valid and expertly recognized scientific names of animals in Brazil. The CTFB is updated in near real time by a team of more than 800 specialists. By January 1, 2024, the CTFB compiled 133,691 nominal species, with 125,138 that were considered valid. Most of the valid species were arthropods (82.3%, with more than 102,000 species) and chordates (7.69%, with over 11,000 species). These taxa were followed by a cluster composed of Mollusca (3,567 species), Platyhelminthes (2,292 species), Annelida (1,833 species), and Nematoda (1,447 species). All remaining groups had less than 1,000 species reported in Brazil, with Cnidaria (831 species), Porifera (628 species), Rotifera (606 species), and Bryozoa (520 species) representing those with more than 500 species. Analysis of the CTFB database can facilitate and direct efforts towards the discovery of new species in Brazil, but it is also fundamental in providing the best available list of valid nominal species to users, including those in science, health, conservation efforts, and any initiative involving animals. The importance of the CTFB is evidenced by the elevated number of citations in the scientific literature in diverse areas of biology, law, anthropology, education, forensic science, and veterinary science, among others.

Recent predictions for quantum-mechanical enhancements in the operation of small heat engines have raised renewed interest in their study both from a fundamental perspective and in view of applications. One essential question is whether collective effects may help to carry enhancements over larger scales, when increasing the number of systems composing the working substance of the engine. Such enhancements may consider not only power and efficiency, that is, its performance, but, additionally, its constancy, that is, the stability of the engine with respect to unavoidable environmental fluctuations. We explore this issue by introducing a many-body quantum heat engine model composed by spin pairs working in continuous operation. We study how power, efficiency, and constancy scale with the number of spins composing the engine and introduce a well-defined macroscopic limit where analytical expressions are obtained. Our results predict power enhancements, in both finite-size and macroscopic cases, for a broad range of system parameters and temperatures, without compromising the engine efficiency, accompanied by coherence-enhanced constancy for finite sizes. We discuss these quantities in connection to thermodynamic uncertainty relations.

The studies of Literature and Theology have acquired great space in the academic environment, both by theoreticians of literature and Theologians. Making use of literary analysis allows us to read theological texts in-depth, contributing to the analysis of theology in what literature, or vice versa, can contribute with resources of form and content. Dante Alighieri was an extraordinary poet who wrote Comedy with great mastery. The work is divided into three parts, hell, purgatory, and paradise. Dante tells us about his trip with another great poet, Virgílio (70 BC) will be your guide through hell and purgatory. In the symbology present in the Comedy, Dante represented the man who walks in the “dark jungle” in search of his redemption. Virgílio represents the reason that guides a man through the darkness. Every corner of the poem is a journey into the theological thought of the Middle Ages and a wealth of rhymes and verses from the Comedy. In paradise, Dante is guided by his childhood love, Beatriz, in Dante's symbolism is faith. Saint Bernard, who represents prayer, the mystic who, in Dante's words, the reason is not enough to reach God, but with faith and prayer., Os estudos da Literatura e Teologia tem adquirido grande espaço no meio acadêmico, tanto por parte de teóricos da literatura como de Teólogos. Fazendo uso de análises literária nos permintindo uma leitura profunda de textos teológicos, contribuindo à análise da teologia naquilo que a literatura, ou vice versa, possa contribuir com recursos de forma e de conteúdo. Dante Alighieri foi um poeta extraordinário que com grande maestria escreveu Comédia. A obra é dividida em três partes, inferno, purgatório e paraíso. Dante nos narra sua viagem com outro grande poeta, Virgílio (70 a.C) será será seu guia pelo inferno e purgatório. Na simbologia presente na Comédia, Dante representado o homem que caminha na “selva escura” na busca de sua redenção. Virgílio representa a razão que guia o homem em meio a escuridão. A cada canto do poema é uma viagem ao pensamento teológica da Idade Média e uma riqueza com as rimas e versos da Comédia. No paraíso, Dante é guiado pelo seu amor de infância, Beatriz, na simbologia de Dante é a fé. São Bernardo, que representa a oração, a mística que no dizer de Dante a razão não é suficiente para alcançar a Deus, mas com fé e oração.

Plants synthesize specialized metabolites to facilitate environmental and ecological interactions. During evolution, plants diversified in their potential to synthesize these metabolites. Quantitative differences in metabolite levels of natural Arabidopsis (Arabidopsis thaliana) accessions can be employed to unravel the genetic basis for metabolic traits using genome-wide association studies (GWAS). Here, we performed metabolic GWAS on seeds of a panel of 315 A. thaliana natural accessions, including the reference genotypes C24 and Col-0, for polar and semi-polar seed metabolites using untargeted ultra-performance liquid chromatography-mass spectrometry. As a complementary approach, we performed quantitative trait locus (QTL) mapping of near-isogenic introgression lines between C24 and Col-0 for specific seed specialized metabolites. Besides common QTL between seeds and leaves, GWAS revealed seed-specific QTL for specialized metabolites, indicating differences in the genetic architecture of seeds and leaves. In seeds, aliphatic methylsulfinylalkyl and methylthioalkyl glucosinolates associated with the ALKENYL HYDROXYALKYL PRODUCING loci (GS-ALK and GS-OHP) on chromosome 4 containing alkenyl hydroxyalkyl producing 2 (AOP2) and 3 (AOP3) or with the GS-ELONG locus on chromosome 5 containing methylthioalkyl malate synthase (MAM1) and MAM3. We detected two unknown sulfur-containing compounds that were also mapped to these loci. In GWAS, some of the annotated flavonoids (kaempferol 3-O-rhamnoside-7-O-rhamnoside, quercetin 3-O-rhamnoside-7-O-rhamnoside) were mapped to transparent testa 7 (AT5G07990), encoding a cytochrome P450 75B1 monooxygenase. Three additional mass signals corresponding to quercetin-containing flavonols were mapped to UGT78D2 (AT5G17050). The association of the loci and associating metabolic features were functionally verified in knockdown mutant lines. By performing GWAS and QTL mapping, we were able to leverage variation of natural populations and par, journal article

The process of crop domestication leads to a dramatic reduction in the gene expression associated with metabolic diversity. Genes involved in specialized metabolism appear to be particularly affected. Although there is ample evidence of these effects at the genetic level, a reduction in diversity at the metabolite level has been taken for granted despite having never been adequately accessed and quantified. Here we leveraged the high coverage of ultra high performance liquid chromatography-high-resolution mass spectrometry based metabolomics to investigate the metabolic diversity in the common bean (Phaseolus vulgaris). Information theory highlights a shift towards lower metabolic diversity and specialization when comparing wild and domesticated bean accessions. Moreover, molecular networking approaches facilitated a broader metabolite annotation than achieved to date, and its integration with gene expression data uncovers a metabolic shift from specialized metabolism towards central metabolism upon domestication of this crop., journal article

The phenylpropanoid pathway of flavonoid biosynthesis has been the subject of considerable research attention. By contrast, the proposed polyketide pathway, also known as the acetate pathway, which provides malonyl-CoA moieties for the C2 elongation reaction catalyzed by chalcone synthase, is less well studied. Here, we identified four genes as candidates for involvement in the supply of cytosolic malonyl-CoA from the catabolism of acyl-CoA, based on coexpression analysis with other flavonoid-related genes. Two of these genes, ACC and KAT5, have been previously characterized with respect to their involvement in lipid metabolism, but no information concerning their relationship to flavonoid biosynthesis is available. To assess the occurrence and importance of the acetate pathway, we characterized the metabolomes of two mutant or transgenic Arabidopsis lines for each of the four enzymes of this putative pathway using a hierarchical approach covering primary and secondary metabolites as well as lipids. Intriguingly, not only flavonoid content but also glucosinolate content was altered in lines deficient in the acetate pathway, as were levels of lipids and most primary metabolites. We discuss these data in the context of our current understanding of flavonoids and lipid metabolism as well as with regard to improving human nutrition.

Plants contain light signaling systems and undergo metabolic perturbation and reprogramming under light stress in order to adapt to environmental changes. Flavonoids are one of the largest classes of natural phytochemical compounds having several biological functions conferring stress defense to plants and health benefits in animal diets. A recent study of phenylacylated-flavonoids (also called hydroxycinnamoylated-flavonoids) of natural accessions of Arabidopsis suggested that phenylacylation of flavonoids relates to selection under different natural light conditions. Phenylacylated-flavonoids which are decorated with hydroxycinnamoyl units, namely cinnamoyl, 4-coumaroyl, caffeoyl, feruloyl and sinapoyl moieties, are widely distributed in the plant kingdom. Currently, more than 400 phenylacylated flavonoids have been reported. Phenylacylation renders enhanced phytochemical functions such as ultraviolet-absorbance and antioxidant activity, although, the physiological role of phenylacylation of flavonoids in plants is largely unknown. In this review, we provide an overview of the occurrence and natural diversity of phenylacylated-flavonoids as well as postulating their biological functions both in planta and with respect to biological activity following their consumption.

Flavonoids are a signature class of secondary metabolites formed from a relatively simple collection of scaffolds. They are extensively decorated by chemical reactions including glycosylation, methylation, and acylation. They are present in a wide variety of fruits and vegetables and as such in Western populations it is estimated that 20–50 mg of flavonoids are consumed daily per person. In planta they have demonstrated to contribute to both flower color and UV protection. Their consumption has been suggested to presenta wide range of health benefits. Recent technical advances allowing affordable whole genome sequencing, as well as a better inventory of species-by-species chemical diversity, have greatly advanced our understanding as to how flavonoid biosynthesis pathways vary across species. In parallel, reverse genetics combined with detailed molecular phenotyping is currently allowing us to elucidate the functional importance of individual genes and metabolites and by this means to provide further mechanistic insight into their biological roles. Here we provide an inventory of current knowledge of pathways of flavonoid biosynthesis in both the model plant Arabidopsis thaliana and a range of crop species, including tomato, maize, rice, and bean.

Cell suspension culture has been used as a model to study metabolic changes to several stresses. To have detailed information of nitrogen (N) limitation on sugarcane metabolism, a controlled study of the primary metabolites and representative compounds of secondary metabolism was developed using suspension cells growing under three different N regimes: normal condition (40 mmol·L–1 NO-3), slightly deficient (12 mmol·L–1 NO-3) and completely deficient (0 mmol·L–1 NO-3). Sugarcane cells were harvested after 3 and 7 days of treatment. A range of changes in the levels of amino acids, organic acids, sugars and phenolic compounds were observed upon the growth conditions applied. Nitrogen limitation remarkably affected the amino acids and carbohydrates biosynthesis, which, associated with the changes observed on phenolic compounds contents, indicates the upregulation of carbon sink compensation mechanisms in these sugarcane cells exposed to N starvation. As expected, the results showed that N limitation might cause an extensive metabolic reprogramming of both carbon and N metabolism in sugarcane cells, and these changes are related to the intensity of the starvation. Nitrogen is essential for plant growth and development, and its limitation sharply reduces crop yield. Thus, these results open new perspectives for in planta studies concerning carbon and N metabolisms balance in this crop.

During the maturation phase of flower development, the onset of anthesis visibly marks the transition from buds to open flowers, during which petals stretch out, nectar secretion commences, and pollination occurs. Analysis of the metabolic changes occurring during this developmental transition has primarily focused on specific classes of metabolites, such as pigments and scent emission, and far less on the whole network of primary and secondary metabolites. To investigate the metabolic changes occurring at anthesis, we performed multi-platform metabolomics alongside RNA sequencing in individual florets harvested from the main inflorescence of Arabidopsis (Arabidopsis thaliana) ecotype Col-0. To trace metabolic fluxes at the level of the whole inflorescence and individual florets, we further integrated these studies with radiolabeled experiments. These extensive analyses revealed high-energy-level metabolism and transport of carbohydrates and amino acids, supporting intense metabolic rearrangements occurring at the time of this floral transition. These comprehensive data are discussed in the context of our current understanding of the metabolic shifts underlying flower opening. We envision that this analysis will facilitate the introgression of floral metabolic traits promoting pollination in crop species for which a comprehensive knowledge of flower metabolism is still limited.

Common bean (Phaseolus vulgaris L.) is an important legume species with a rich natural diversity of lan-draces that originated from the wild forms following multiple independent domestication events. After the publication of its genome, several resources for this relevant crop have been made available. A comprehen-sive characterization of specialized metabolism in P. vulgaris, however, is still lacking. In this study, we used a metabolomics approach based on liquid chromatography-mass spectrometry to dissect the chemical composition at a tissue-specific level in several accessions of common bean belonging to different gene pools. Using a combination of literature search, mass spectral interpretation, 13C-labeling, and correlation analyses, we were able to assign chemical classes and/or putative structures for approximately 39% of all measured metabolites. Additionally, we integrated this information with transcriptomics data and phyloge-netic inference from multiple legume species to reconstruct the possible metabolic pathways and identify sets of candidate genes involved in the biosynthesis of specialized metabolites. A particular focus was given to flavonoids, triterpenoid saponins and hydroxycinnamates, as they represent metabolites involved in important ecological interactions and they are also associated with several health-promoting benefits when integrated into the human diet. The data are presented here in the form of an accessible resource that we hope will set grounds for further studies on specialized metabolism in legumes.

This article intends to analyze the appropriation of the work El Protestantismo comparado con el Catolicismo en sus Relaciones con la Civilizacion Europea, by the monarchist theologian Jaime Luciano Balmes Uría (1810-1848), by the main ultramontane brazilian newspaper of the second half of the nineteenth century: O Apóstolo, published in the province of Rio de Janeiro between 1866 and 1901 as one of the main spokespersons of ultramontane ideals and projects, in tune with some of the Holy See's directives for the Catholic world at the time, aiming to stop the advance of the supposed “errors of modernity”. Having as a fundamental problem the process of circulation of ideas and cultural appropriation, it aims to compare the appropriations by the newspaper of excerpts and ideas present in Balmes' work, written in the context of the legitimist reaction to the sociopolitical vicissitudes and theological debates that marked Spain in the 1840s, identifying its adaptations and resignifications in the light of the Brazilian reality of the time, concomitant to the dynamics of printed circulation in a transnational perspective, Este artigo pretende analisar a apropriação da obra El Protestantismo comparado con el Catolicismo en sus Relaciones con la Civilizacion Europea, do teólogo monarquista Jaime Luciano Balmes Uría (1810-1848), pelo principal jornal ultramontano brasileiro da segunda metade do século XIX: O Apóstolo, editado na província do Rio de Janeiro entre os anos de 1866 e 1901 na condição de um dos principais porta-vozes dos ideais e projetos ultramontanos, afinados com algumas das diretrizes da Santa Sé para o mundo católico da época, visando a barrar o avanço dos supostos “erros da modernidade”. Tendo como problemática de fundo o processo de circulação de ideias e apropriação cultural, visa a cotejar as apropriações pelo jornal de trechos e ideias presentes na obra de Balmes, escrita no contexto da reação legitimista às vicissitudes sociopolíticas e aos debates teológicos que marcaram a Espanha na década de 1840, identificando suas adaptações e ressignificações à luz da realidade brasileira da época, concomitante a dinâmica de circulação de impressos em perspectiva transnacional.

We aimed to build and analyze the psychometric properties of an instrument to assess grati-tude in situational judgment format. After the analysis of judges’ and pilot study, 6 items out of the 15 elaborated were excluded. In the internal structure study 514 people participated, being 56% female, aged between 14 and 72 years old, who answered the Gratitude Scale, Af-fections Scale, Vitality Scale and Life Satisfaction Scale. The exploratory factor analysis indi-cated a one-dimensional structure composed of 9 items. Women had the highest averages when compared to men, both in judgment and in the self-assessment of gratitude. The grati-tude presented positively correlation with weak magnitude only with vitality, being positively explained by the gratitude. The data indicated evidence of validity based on the test content, on its internal consistency and in the relationship to external variables for the Gratitude Scale, Objetivamos construir e analisar as propriedades psicométricas de um instrumento para avaliar a gratidão em formato de julgamento situacional. Após a análise de juízes e estudo piloto, houve a exclusão de 6 itens dos 15 elaborados inicialmente. No estudo de busca de evidência de validade por meio da estrutura interna participaram 514 pessoas, sendo 56% do sexo femini-no, com idades entre 14 e 72 anos, que responderam à Escala de Gratidão, Escala de Afetos, Escala de Vitalidade e a Escala de Satisfação com a Vida. A análise fatorial exploratória indicou uma estrutura unidimensional composta por 9 itens. As mulheres apresentaram as maiores mé-dias quando comparadas aos homens, tanto no julgamento como na autoavaliação da gratidão. A gratidão apresentou correlação, em sentido positivo com magnitude fraca, apenas com a vi-talidade. Os dados indicaram evidências de validade com base no conteúdo do teste, consistên-cia interna e na relação com variáveis externas para a Escala de Gratidão

The expression ‘you need to know to conserve’ is a well-known cliche among biologists. Documenting the richness of a group of organisms is the first step towards understanding biodiversity and preparing efficient conservation plans. In this context, many efforts have been made to quantify the number of species on Earth and estimate the number of species still unknown to science. A few countries have complete and integrated databases estimating the approximate number of species recorded for their territory, particularly in the Global South. In Brazil, a country of continental dimensions, revealing the richness of the second most diverse clade of invertebrates (=Mollusca) has been a goal of taxonomists. Recently, in an unprecedented, collective, and integrated effort among Brazilian malacologists, it was possible to estimate how many valid species of molluscs are there in Brazil. In this effort, more than 30 mollusc experts joined together to update the Taxonomic Catalogue of the Brazilian Fauna (TCBF), a governmental website that allows a quick and real-time updating of all Metazoan. So far, more than 5,000 updates have been made in TCBF, indicating the presence of 3,552 valid species of molluscs in Brazil, distributed among the main clades as follows: Caudofoveata (10 spp.), Solenogastres (6 spp.), Polyplacophora (35 spp.), Scaphopoda (43 spp.), Cephalopoda (92 spp.), Bivalvia (629 spp.) and Gastropoda (2,737 spp.). The present study, in addition to demonstrating for the first time the richness of Brazilian molluscs, also presents the state of the art of this important phylum of invertebrates highlighting its most representative and neglected groups.

Frontotemporal dementia (FTD) is one of the leading causes of dementia before age 65 and often manifests as abnormal behavior (in behavioral variant FTD) or language impairment (in primary progressive aphasia). FTD's exact clinical presentation varies by culture, language, education, social norms, and other socioeconomic factors; current research and clinical practice, however, is mainly based on studies conducted in North America and Western Europe. Changes in diagnostic criteria and procedures as well as new or adapted cognitive tests are likely needed to take into consideration global diversity. This perspective paper by two professional interest areas of the Alzheimer's Association International Society to Advance Alzheimer's Research and Treatment examines how increasing global diversity impacts the clinical presentation, screening, assessment, and diagnosis of FTD and its treatment and care. It subsequently provides recommendations to address immediate needs to advance global FTD research and clinical practice.

The studies of Literature and Theology have acquired great space in the academic environment, both by theoreticians of literature and Theologians. Making use of literary analysis allows us to read theological texts in-depth, contributing to the analysis of theology in what literature, or vice versa, can contribute with resources of form and content. Dante Alighieri was an extraordinary poet who wrote Comedy with great mastery. The work is divided into three parts, hell, purgatory, and paradise. Dante tells us about his trip with another great poet, Virgílio (70 BC) will be your guide through hell and purgatory. In the symbology present in the Comedy, Dante represented the man who walks in the “dark jungle” in search of his redemption. Virgílio represents the reason that guides a man through the darkness. Every corner of the poem is a journey into the theological thought of the Middle Ages and a wealth of rhymes and verses from the Comedy. In paradise, Dante is guided by his childhood love, Beatriz, in Dante's symbolism is faith. Saint Bernard, who represents prayer, the mystic who, in Dante's words, the reason is not enough to reach God, but with faith and prayer., Os estudos da Literatura e Teologia tem adquirido grande espaço no meio acadêmico, tanto por parte de teóricos da literatura como de Teólogos. Fazendo uso de análises literária nos permintindo uma leitura profunda de textos teológicos, contribuindo à análise da teologia naquilo que a literatura, ou vice versa, possa contribuir com recursos de forma e de conteúdo. Dante Alighieri foi um poeta extraordinário que com grande maestria escreveu Comédia. A obra é dividida em três partes, inferno, purgatório e paraíso. Dante nos narra sua viagem com outro grande poeta, Virgílio (70 a.C) será será seu guia pelo inferno e purgatório. Na simbologia presente na Comédia, Dante representado o homem que caminha na “selva escura” na busca de sua redenção. Virgílio representa a razão que guia o homem em meio a escuridão. A cada canto do poema é uma viagem ao pensamento teológica da Idade Média e uma riqueza com as rimas e versos da Comédia. No paraíso, Dante é guiado pelo seu amor de infância, Beatriz, na simbologia de Dante é a fé. São Bernardo, que representa a oração, a mística que no dizer de Dante a razão não é suficiente para alcançar a Deus, mas com fé e oração.

Low-density lipoprotein (LDL)-cholesterol delivery from late endosomes to the plasma membrane regulates focal adhesion dynamics and cell migration, but the mechanisms controlling it are poorly characterized. Here, we employed auxin-inducible rapid degradation of oxysterol-binding protein-related protein 2 (ORP2/OSBPL2) to show that endogenous ORP2 mediates the transfer of LDL-derived cholesterol from late endosomes to focal adhesion kinase (FAK)-/integrin-positive recycling endosomes in human cells. In vitro, cholesterol enhances membrane association of FAK to PI(4,5)P2-containing lipid bilayers. In cells, ORP2 stimulates FAK activation and PI(4,5)P2 generation in endomembranes, enhancing cell adhesion. Moreover, ORP2 increases PI(4,5)P2 in NPC1-containing late endosomes in a FAK-dependent manner, controlling their tubulovesicular trafficking. Together, these results provide evidence that ORP2 controls FAK activation and LDL-cholesterol plasma membrane delivery by promoting bidirectional cholesterol/PI(4,5)P2 exchange between late and recycling endosomes.

Since 2019, humanity has faced the pandemic outbreak of COVID-19 disease, caused by the new coronavirus, SARS-CoV-2. Respiratory symptoms of the disease were investigated and monitored worldwide, however, the nervous system lesions induced by COVID-19 did not receive as much attention. The aim of this study was to highlight the neurological alterations after infection of the new coronavirus, thus highlighting the symptoms that remained after Infection by SARS-CoV-2. The review shows relevant data on drugs and SARS-CoV-2, neurological alterations, complications and adverse effects related to COVID-19. At the time of writing this article, in mid-2022, SARS-CoV-2 is still spreading in several countries and infecting the population, leaving many people with temporary or permanent sequelae because of COVID-19.

Since 2019, humanity has faced the pandemic outbreak of COVID-19 disease, caused by the new coronavirus, SARS-CoV-2. Respiratory symptoms of the disease were investigated and monitored worldwide, however, the nervous system lesions induced by COVID-19 did not receive as much attention. The aim of this study was to highlight the neurological alterations after infection of the new coronavirus, thus highlighting the symptoms that remained after Infection by SARS-CoV-2. The review shows relevant data on drugs and SARS-CoV-2, neurological alterations, complications and adverse effects related to COVID-19. At the time of writing this article, in mid-2022, SARS-CoV-2 is still spreading in several countries and infecting the population, leaving many people with temporary or permanent sequelae because of COVID-19.

During the maturation phase of flower development, the onset of anthesis visibly marks the transition from buds to open flowers, during which petals stretch out, nectar secretion commences, and pollination occurs. Analysis of the metabolic changes occurring during this developmental transition has primarily focused on specific classes of metabolites, such as pigments and scent emission, and far less on the whole network of primary and secondary metabolites. To investigate the metabolic changes occurring at anthesis, we performed multi-platform metabolomics alongside RNA sequencing in individual florets harvested from the main inflorescence of Arabidopsis (Arabidopsis thaliana) ecotype Col-0. To trace metabolic fluxes at the level of the whole inflorescence and individual florets, we further integrated these studies with radiolabeled experiments. These extensive analyses revealed high-energy-level metabolism and transport of carbohydrates and amino acids, supporting intense metabolic rearrangements occurring at the time of this floral transition. These comprehensive data are discussed in the context of our current understanding of the metabolic shifts underlying flower opening. We envision that this analysis will facilitate the introgression of floral metabolic traits promoting pollination in crop species for which a comprehensive knowledge of flower metabolism is still limited., identifier:1532-2548

During the maturation phase of flower development, the onset of anthesis visibly marks the transition from buds to open flowers, during which petals stretch out, nectar secretion commences, and pollination occurs. Analysis of the metabolic changes occurring during this developmental transition has primarily focused on specific classes of metabolites, such as pigments and scent emission, and far less on the whole network of primary and secondary metabolites. To investigate the metabolic changes occurring at anthesis, we performed multi-platform metabolomics alongside RNA sequencing in individual florets harvested from the main inflorescence of Arabidopsis (Arabidopsis thaliana) ecotype Col-0. To trace metabolic fluxes at the level of the whole inflorescence and individual florets, we further integrated these studies with radiolabeled experiments. These extensive analyses revealed high-energy-level metabolism and transport of carbohydrates and amino acids, supporting intense metabolic rearrangements occurring at the time of this floral transition. These comprehensive data are discussed in the context of our current understanding of the metabolic shifts underlying flower opening. We envision that this analysis will facilitate the introgression of floral metabolic traits promoting pollination in crop species for which a comprehensive knowledge of flower metabolism is still limited.

We live in a historical period marked by the growing demand for the production of scientific knowledge. The protagonists of this enterprise are the Graduate Programs that are dedicated to scientific production and the training of researchers-professors committed to social transformation and the democratization of knowledge. The present study aims to problematize the objective and subjective conditions of this production, emphasizing the need to favor an affective sustainability in the academic context. Therefore, the research was divided into three moments. First, a brief history of Psychology as science is exposed. Next, we address the possibility of building affective sustainability in universities. Finally, we present disobedience as a strategy of resistance to the empty productivism of science. In conclusion, the study shows that research, in addition to its objective results, also involves the experimentation of multiple affects that are the condition of possibility to leverage social and political transformations in our country., Vivemos em um tempo histórico marcado pela exigência crescente de produção de conhecimento científico. Os protagonistas desse empreendimento são os Programas de Pós-graduação que se dedicam à produção científica e à formação de pesquisadores-professores comprometidos com a transformação social e com a democratização do conhecimento. O presente estudo busca problematizar as condições objetivas e subjetivas dessa produção, enfatizando a necessidade de favorecer uma sustentabilidade afetiva no contexto acadêmico. Para tanto, a pesquisa foi dividida em três momentos. Primeiro, é exposto um breve histórico da Psicologia como ciência. Em seguida, abordamos a possibilidade de construir uma sustentabilidade afetiva nas universidades. Por fim, apresentamos a desobediência como estratégia de resistência ao produtivismo vazio das ciências. Como conclusão, o estudo mostra que as pesquisas, para além de seus resultados objetivos, envolve também a experimentação de múltiplos afetos que são a condição de possibilidade para alavancar transformações sociais e políticas em nosso país., Vivimos en un tiempo histórico marcado por la creciente demanda de producción de conocimiento científico. Los protagonistas de esta empresa son los Programas de Posgrado dedicados a la producción científica y la formación de investigadores-profesores comprome tidos con la transformación social y la democratización del conocimiento. El presente estudio busca problematizar las condiciones objetivas y subjetivas de esta producción, destacando la necesidad de favorecer la sostenibilidad afectiva en el contexto académico. Por lo tanto, la investigación se dividió en tres momentos. Primero, una breve historia de la psicología a medida que se expone la ciencia. A continuación, abordamos la posibilidad de construir sostenibilidad afectiva en las universidades. Por último, presentamos la desobediencia como una estrategia de resistencia al productivismo vacío de las ciencias. En conclusión, el estudio muestra que la investigación, además de sus resultados objetivos, también implica la experimentación de múltiples afectos que son la condición de posibilidad de aprovechar las transformaciones sociales y políticas en nuestro país.

During the maturation phase of flower development, the onset of anthesis visibly marks the transition from buds to open flowers, during which petals stretch out, nectar secretion commences, and pollination occurs. Analysis of the metabolic changes occurring during this developmental transition has primarily focused on specific classes of metabolites, such as pigments and scent emission, and far less on the whole network of primary and secondary metabolites. To investigate the metabolic changes occurring at anthesis, we performed multi-platform metabolomics alongside RNA sequencing in individual florets harvested from the main inflorescence of Arabidopsis (Arabidopsis thaliana) ecotype Col-0. To trace metabolic fluxes at the level of the whole inflorescence and individual florets, we further integrated these studies with radiolabeled experiments. These extensive analyses revealed high-energy-level metabolism and transport of carbohydrates and amino acids, supporting intense metabolic rearrangements occurring at the time of this floral transition. These comprehensive data are discussed in the context of our current understanding of the metabolic shifts underlying flower opening. We envision that this analysis will facilitate the introgression of floral metabolic traits promoting pollination in crop species for which a comprehensive knowledge of flower metabolism is still limited., journal article

We live in a historical period marked by the growing demand for the production of scientific knowledge. The protagonists of this enterprise are the Graduate Programs that are dedicated to scientific production and the training of researchers-professors committed to social transformation and the democratization of knowledge. The present study aims to problematize the objective and subjective conditions of this production, emphasizing the need to favor an affective sustainability in the academic context. Therefore, the research was divided into three moments. First, a brief history of Psychology as science is exposed. Next, we address the possibility of building affective sustainability in universities. Finally, we present disobedience as a strategy of resistance to the empty productivism of science. In conclusion, the study shows that research, in addition to its objective results, also involves the experimentation of multiple affects that are the condition of possibility to leverage social and political transformations in our country., Vivemos em um tempo histórico marcado pela exigência crescente de produção de conhecimento científico. Os protagonistas desse empreendimento são os Programas de Pós-graduação que se dedicam à produção científica e à formação de pesquisadores-professores comprometidos com a transformação social e com a democratização do conhecimento. O presente estudo busca problematizar as condições objetivas e subjetivas dessa produção, enfatizando a necessidade de favorecer uma sustentabilidade afetiva no contexto acadêmico. Para tanto, a pesquisa foi dividida em três momentos. Primeiro, é exposto um breve histórico da Psicologia como ciência. Em seguida, abordamos a possibilidade de construir uma sustentabilidade afetiva nas universidades. Por fim, apresentamos a desobediência como estratégia de resistência ao produtivismo vazio das ciências. Como conclusão, o estudo mostra que as pesquisas, para além de seus resultados objetivos, envolve também a experimentação de múltiplos afetos que são a condição de possibilidade para alavancar transformações sociais e políticas em nosso país., Vivimos en un tiempo histórico marcado por la creciente demanda de producción de conocimiento científico. Los protagonistas de esta empresa son los Programas de Posgrado dedicados a la producción científica y la formación de investigadores-profesores comprome tidos con la transformación social y la democratización del conocimiento. El presente estudio busca problematizar las condiciones objetivas y subjetivas de esta producción, destacando la necesidad de favorecer la sostenibilidad afectiva en el contexto académico. Por lo tanto, la investigación se dividió en tres momentos. Primero, una breve historia de la psicología a medida que se expone la ciencia. A continuación, abordamos la posibilidad de construir sostenibilidad afectiva en las universidades. Por último, presentamos la desobediencia como una estrategia de resistencia al productivismo vacío de las ciencias. En conclusión, el estudio muestra que la investigación, además de sus resultados objetivos, también implica la experimentación de múltiples afectos que son la condición de posibilidad de aprovechar las transformaciones sociales y políticas en nuestro país.

Since 2019, humanity has faced the pandemic outbreak of COVID-19 disease, caused by the new coronavirus, SARS-CoV-2. Respiratory symptoms of the disease were investigated and monitored worldwide, however, the nervous system lesions induced by COVID-19 did not receive as much attention. The aim of this study was to highlight the neurological alterations after infection of the new coronavirus, thus highlighting the symptoms that remained after Infection by SARS-CoV-2. The review shows relevant data on drugs and SARS-CoV-2, neurological alterations, complications and adverse effects related to COVID-19. At the time of writing this article, in mid-2022, SARS-CoV-2 is still spreading in several countries and infecting the population, leaving many people with temporary or permanent sequelae because of COVID-19.

Since 2019, humanity has faced the pandemic outbreak of COVID-19 disease, caused by the new coronavirus, SARS-CoV-2. Respiratory symptoms of the disease were investigated and monitored worldwide, however, the nervous system lesions induced by COVID-19 did not receive as much attention. The aim of this study was to highlight the neurological alterations after infection of the new coronavirus, thus highlighting the symptoms that remained after Infection by SARS-CoV-2. The review shows relevant data on drugs and SARS-CoV-2, neurological alterations, complications and adverse effects related to COVID-19. At the time of writing this article, in mid-2022, SARS-CoV-2 is still spreading in several countries and infecting the population, leaving many people with temporary or permanent sequelae because of COVID-19.

This article deals with the course of queer theory, since the 1990s, and the current debate about queer theory's antisocial policy. By the interdisciplinary thinking from which the debate on gender initiated the discussion about a queer gender theory, the author's criticism is, above all, at the heart of the meaning of queer thinking as a theory of practice, as long as its relation with practices - through debate - can successfully translate the claims of that thought, that is, that gender and sexuality are different things. Based on the confrontation of ideas between Cultural Studies, Social Sciences and Psychoanalysis, the author seeks to criticize the establishment of queer as another identity on the gender spectrum., Este artigo trata sobre o percurso da teoria queer, desde os anos 1990, e o atual debate sobre a política antissocial da teoria queer. Abordando o pensamento interdisciplinar do qual o debate sobre gênero iniciou a discussão acerca de uma teoria de gênero queer, a crítica da autora está, sobretudo, no cerne do significado do pensamento queer enquanto uma teoria da prática, contanto que a sua relação com as práticas - através do debate - possa traduzir com êxito as pretensões desse pensamento, ou seja, que gênero e sexualidade são coisas distintas. A partir do confronto de ideias entre Estudos Culturais, Ciências Sociais e Psicanálise, a autora busca criticar o estabelecimento do queer como mais uma identidade no espectro do gênero. Dessa forma, compreende-se que o debate ainda está em devir.

Across Latin American and Caribbean countries (LACs), the fight against dementia faces pressing challenges, such as heterogeneity, diversity, political instability, and socioeconomic disparities. These can be addressed more effectively in a collaborative setting that fosters open exchange of knowledge. In this work, the Latin American and Caribbean Consortium on Dementia (LAC-CD) proposes an agenda for integration to deliver a Knowledge to Action Framework (KtAF). First, we summarize evidence-based strategies (epidemiology, genetics, biomarkers, clinical trials, nonpharmacological interventions, networking, and translational research) and align them to current global strategies to translate regional knowledge into transformative actions. Then we characterize key sources of complexity (genetic isolates, admixture in populations, environmental factors, and barriers to effective interventions), map them to the above challenges, and provide the basic mosaics of knowledge toward a KtAF. Finally, we describe strategies supporting the knowledge creation stage that underpins the translational impact of KtAF.

Information is essential for organizations’ competitiveness, in which software processes a large amount of data. Programmers develop technologies based on the creation and sharing of knowledge. Tacit knowledge is strategic, resulting from work experience requiring socialization and a favorable context to be developed. A cooperative environment results from a positive organizational climate and satisfaction of the employees’ needs. Organizational climate reflects the culture, which determines corporate values and practices. However, academic literature shows that there is considerable stress among software professionals, resulting from workload. This paper objective is to verify, in a software company, the relationship between organizational culture, climate and knowledge sharing. A case study was carried out in a company in Marília City, São Paulo State, Brazil, which has a Local Productive Arrangement of Information Technology. Knowledge Management, Psychology, Administration, organizational behavior and software development theoretical contributions were used., A informação é fundamental para a competitividade das organizações, nas quais os softwares processam grande quantidade de dados. Programadores elaboram tecnologias apoiando-se na criação e compartilhamento de conhecimentos. O conhecimento tácito é estratégico, resultante da experiência de trabalho requerendo a socialização e um contexto favorável para se desenvolver. Um ambiente de cooperação resulta do clima organizacional positivo e satisfação das necessidades dos colaboradores. O clima organizacional reflete a cultura, que determina valores e práticas empresariais. Contudo, a literatura mostra que há considerável stress entre profissionais de software, resultante da carga de trabalho. Objetiva-se verificar, em uma empresa de software, a relação entre cultura organizacional, clima e compartilhamento de conhecimentos. Efetuou-se um estudo de caso em uma empresa do município de Marília/SP, que detém um Arranjo Produtivo Local de Tecnologia da Informação. Utilizou-se aportes da Gestão do Conhecimento, Psicologia, Administração, comportamento organizacional e desenvolvimento de software.

Cell suspension culture has been used as a model to study metabolic changes to several stresses. To have detailed information of nitrogen (N) limitation on sugarcane metabolism, a controlled study of the primary metabolites and representative compounds of secondary metabolism was developed using suspension cells growing under three different N regimes: normal condition (40 mmol·L–1 NO-3), slightly deficient (12 mmol·L–1 NO-3) and completely deficient (0 mmol·L–1 NO-3). Sugarcane cells were harvested after 3 and 7 days of treatment. A range of changes in the levels of amino acids, organic acids, sugars and phenolic compounds were observed upon the growth conditions applied. Nitrogen limitation remarkably affected the amino acids and carbohydrates biosynthesis, which, associated with the changes observed on phenolic compounds contents, indicates the upregulation of carbon sink compensation mechanisms in these sugarcane cells exposed to N starvation. As expected, the results showed that N limitation might cause an extensive metabolic reprogramming of both carbon and N metabolism in sugarcane cells, and these changes are related to the intensity of the starvation. Nitrogen is essential for plant growth and development, and its limitation sharply reduces crop yield. Thus, these results open new perspectives for in planta studies concerning carbon and N metabolisms balance in this crop., identifier:1678-4499

Across Latin American and Caribbean countries (LACs), the fight against dementia faces pressing challenges, such as heterogeneity, diversity, political instability, and socioeconomic disparities. These can be addressed more effectively in a collaborative setting that fosters open exchange of knowledge. In this work, the Latin American and Caribbean Consortium on Dementia (LAC-CD) proposes an agenda for integration to deliver a Knowledge to Action Framework (KtAF). First, we summarize evidence-based strategies (epidemiology, genetics, biomarkers, clinical trials, nonpharmacological interventions, networking, and translational research) and align them to current global strategies to translate regional knowledge into transformative actions. Then we characterize key sources of complexity (genetic isolates, admixture in populations, environmental factors, and barriers to effective interventions), map them to the above challenges, and provide the basic mosaics of knowledge toward a KtAF. Finally, we describe strategies supporting the knowledge creation stage that underpins the translational impact of KtAF.

Information is essential for organizations’ competitiveness, in which software processes a large amount of data. Programmers develop technologies based on the creation and sharing of knowledge. Tacit knowledge is strategic, resulting from work experience requiring socialization and a favorable context to be developed. A cooperative environment results from a positive organizational climate and satisfaction of the employees’ needs. Organizational climate reflects the culture, which determines corporate values and practices. However, academic literature shows that there is considerable stress among software professionals, resulting from workload. This paper objective is to verify, in a software company, the relationship between organizational culture, climate and knowledge sharing. A case study was carried out in a company in Marília City, São Paulo State, Brazil, which has a Local Productive Arrangement of Information Technology. Knowledge Management, Psychology, Administration, organizational behavior and software development theoretical contributions were used., A informação é fundamental para a competitividade das organizações, nas quais os softwares processam grande quantidade de dados. Programadores elaboram tecnologias apoiando-se na criação e compartilhamento de conhecimentos. O conhecimento tácito é estratégico, resultante da experiência de trabalho requerendo a socialização e um contexto favorável para se desenvolver. Um ambiente de cooperação resulta do clima organizacional positivo e satisfação das necessidades dos colaboradores. O clima organizacional reflete a cultura, que determina valores e práticas empresariais. Contudo, a literatura mostra que há considerável stress entre profissionais de software, resultante da carga de trabalho. Objetiva-se verificar, em uma empresa de software, a relação entre cultura organizacional, clima e compartilhamento de conhecimentos. Efetuou-se um estudo de caso em uma empresa do município de Marília/SP, que detém um Arranjo Produtivo Local de Tecnologia da Informação. Utilizou-se aportes da Gestão do Conhecimento, Psicologia, Administração, comportamento organizacional e desenvolvimento de software.

Cell suspension culture has been used as a model to study metabolic changes to several stresses. To have detailed information of nitrogen (N) limitation on sugarcane metabolism, a controlled study of the primary metabolites and representative compounds of secondary metabolism was developed using suspension cells growing under three different N regimes: normal condition (40 mmol·L–1 NO-3), slightly deficient (12 mmol·L–1 NO-3) and completely deficient (0 mmol·L–1 NO-3). Sugarcane cells were harvested after 3 and 7 days of treatment. A range of changes in the levels of amino acids, organic acids, sugars and phenolic compounds were observed upon the growth conditions applied. Nitrogen limitation remarkably affected the amino acids and carbohydrates biosynthesis, which, associated with the changes observed on phenolic compounds contents, indicates the upregulation of carbon sink compensation mechanisms in these sugarcane cells exposed to N starvation. As expected, the results showed that N limitation might cause an extensive metabolic reprogramming of both carbon and N metabolism in sugarcane cells, and these changes are related to the intensity of the starvation. Nitrogen is essential for plant growth and development, and its limitation sharply reduces crop yield. Thus, these results open new perspectives for in planta studies concerning carbon and N metabolisms balance in this crop., journal article

Cell suspension culture has been used as a model to study metabolic changes to several stresses. To have detailed information of nitrogen (N) limitation on sugarcane metabolism, a controlled study of the primary metabolites and representative compounds of secondary metabolism was developed using suspension cells growing under three different N regimes: normal condition (40 mmol·L–1 NO-3), slightly deficient (12 mmol·L–1 NO-3) and completely deficient (0 mmol·L–1 NO-3). Sugarcane cells were harvested after 3 and 7 days of treatment. A range of changes in the levels of amino acids, organic acids, sugars and phenolic compounds were observed upon the growth conditions applied. Nitrogen limitation remarkably affected the amino acids and carbohydrates biosynthesis, which, associated with the changes observed on phenolic compounds contents, indicates the upregulation of carbon sink compensation mechanisms in these sugarcane cells exposed to N starvation. As expected, the results showed that N limitation might cause an extensive metabolic reprogramming of both carbon and N metabolism in sugarcane cells, and these changes are related to the intensity of the starvation. Nitrogen is essential for plant growth and development, and its limitation sharply reduces crop yield. Thus, these results open new perspectives for in planta studies concerning carbon and N metabolisms balance in this crop.

Apesar dos diversos benefícios mencionados pela literatura acerca do uso de metodologias ativas na educação superior em saúde para a promoção de uma aprendizagem significativa, tais métodos têm encontrado dificuldades para efetivar-se no Brasil. Uma vez que a superação de uma problemática necessita de um diagnóstico que permita intervenções eficientes, este estudo analisou a produção nacional sobre metodologias ativas no ensino superior em saúde entre 2013 e 2018.  Trata-se de uma revisão integrativa em 5 bases de dados nacionais e internacionais, que resultou de 42 estudos elegíveis.  A maior parte da literatura (73,8%), advém de relatos de experiência e séries de casos, (níveis VI e VII de evidência) publicados em 2016 e 2017, realizados por instituições públicas (78,6%) e sem financiamento (71,4%). Foram desenvolvidas nos cursos de Enfermagem (35,7%) e Medicina (19%), buscando compreender a percepção dos estudantes (28,6%) sobre a inserção de metodologias ativas, especialmente da Aprendizagem Baseada em Problemas (25%). As principais vantagens mencionadas acerca das metodologias ativas foram a promoção de autonomia e pensamento crítico e holístico no estudante. Já os aspectos que ameaçam a efetivação da aprendizagem ativa, versaram sobre os currículos tradicionais, infraestrutura precária e, uma formação docente deficitária.  O baixo investimento em pesquisas pode justificar a dificuldade de efetivação das metodologias ativas, reforçando o uso intensivo de uma pedagogia tradicional curricular que reduz o incômodo que uma educação para a saúde brasileira baseada em evidências pode trazer a todos os indivíduos de uma cultura passiva de aprendizagem.

Recent predictions for quantum-mechanical enhancements in the operation of small heat engines have raised renewed interest in their study from both a fundamental perspective and in view of applications. One essential question is whether collective effects may help to carry enhancements over larger scales, when increasing the number of systems composing the working substance of the engine. Such enhancements may consider not only power and efficiency, that is its performance, but, additionally, its constancy, i.e. the stability of the engine with respect to unavoidable environmental fluctuations. We explore this issue by introducing a many-body quantum heat engine model composed by spin pairs working in continuous operation. We study how power, efficiency and constancy scale with the number of spins composing the engine and introduce a well-defined macroscopic limit where analytical expressions are obtained. Our results predict power enhancements, both in finite-size and macroscopic cases, for a broad range of system parameters and temperatures, without compromising the engine efficiency, accompanied by coherence-enhanced constancy for finite sizes. We discuss these quantities in connection to Thermodynamic Uncertainty Relations (TUR).

Pretende-se discorrer sobre a efetivação do direito fundamental à saúde por meio de decisões do Poder Judiciário no Estado Contemporâneo. Para tanto, serão apresentados instrumentos jurídicos com os quais é possível a fruição de tais direitos de forma eficiente, tal como determina a Constituição da República Federativa do Brasil. A necessidade e importância desse estudo se devem à progressiva busca para a efetivação dos direitos sociais, contribuindo para aprimoramento dos estudos relacionados aos direitos fundamentais.

Pretende-se discorrer sobre a efetivação do direito fundamental à saúde por meio de decisões do Poder Judiciário no Estado Contemporâneo. Para tanto, serão apresentados instrumentos jurídicos com os quais é possível a fruição de tais direitos de forma eficiente, tal como determina a Constituição da República Federativa do Brasil. A necessidade e importância desse estudo se devem à progressiva busca para a efetivação dos direitos sociais, contribuindo para aprimoramento dos estudos relacionados aos direitos fundamentais.

The behavioural variant of frontotemporal dementia (bvFTD) is a frequent cause of early-onset dementia. The diagnosis of bvFTD remains challenging because of the limited accuracy of neuroimaging in the early disease stages and the absence of molecular biomarkers, and therefore relies predominantly on clinical assessment. BvFTD shows significant symptomatic overlap with non-degenerative primary psychiatric disorders including major depressive disorder, bipolar disorder, schizophrenia, obsessive-compulsive disorder, autism spectrum disorders and even personality disorders. To date, ∼50% of patients with bvFTD receive a prior psychiatric diagnosis, and average diagnostic delay is up to 5-6 years from symptom onset. It is also not uncommon for patients with primary psychiatric disorders to be wrongly diagnosed with bvFTD. The Neuropsychiatric International Consortium for Frontotemporal Dementia was recently established to determine the current best clinical practice and set up an international collaboration to share a common dataset for future research. The goal of the present paper was to review the existing literature on the diagnosis of bvFTD and its differential diagnosis with primary psychiatric disorders to provide consensus recommendations on the clinical assessment. A systematic literature search with a narrative review was performed to determine all bvFTD-related diagnostic evidence for the following topics: bvFTD history taking, psychiatric assessment, clinical scales, physical and neurological examination, bedside cognitive tests, neuropsychological assessment, social cognition, structural neuroimaging, functional neuroimaging, CSF and genetic testing. For each topic, responsible team members proposed a set of minimal requirements, optimal clinical recommendations, and tools requiring further research or those that should be developed. Recommendations were listed if they reached a ≥ 85% expert consensus based on an online survey among all consortium participa

The aim of this study was to know the subjectivation process of teachers about gender, sexuality and childhood in their educational practices. For this, an intervention research was conducted with the purpose of organizing dialogues with early childhood educators of a Municipal Center of Early Childhood Education. Workshops and interviews were conducted to collect data. We identified the use of gender technologies by teachers in the production of normalized childhoods, and how the school acts as an agent that puts this normalization into action. Among them, we identified ways of acting in the pedagogical process with children, the strength of discourses such as the identification of sexualities based on binary gender stereotypes, as well as interventions to correct deviations in the route of sexualities and genders. We perceive the effects of play and the relationship of the sex / gender mechanism that permeates play through the mediation of adults and the naturalizing and normalizing discourses. The research aimed to create a space for training and debate between researcher and educators in which questions about the normalization of genders and sexualities could be put in motion. It concludes with some considerations about the potential possibilities of early childhood education in breaking from binary and heternormative discourses about genders and sexualities from an early age., O objetivo deste estudo foi conhecer o processo de subjetivação dos professores sobre gênero, sexualidade e infância em suas práticas educativas. Foi realizada uma pesquisa-intervenção com o objetivo de dialogar com os educadores de um Centro Local de Educação Infantil. Realizaram-se oficinas e entrevistas para coletar dados. Identificamos o uso de tecnologias de gênero pelos professores na produção de infâncias padronizadas e como a escola atua como um agente que coloca essa padronização em ação. Dentre elas identificamos formas de atuar no processo pedagógico junto às crianças, a força de discursos como o da identificaçao das sexualidades a partir dos estereotipos binários de gênero, bem como das intervenções no sentido de corrigir os desvios de rota das sexualidades e dos gêneros. Ao mesmo tempo percebemos os os efeitos do brincar e a relação do mecanismo sexo/gênero que perpassam as brincadeiras pela mediação dos adultos e os discursos naturalizantes e normalizadores. A pesquisa se propôs a criar um espaço de formação e debate entre pesquisador e educadoras em que problematizações sobre as normalizações sobre gêneros e sexualidades pudessem ser colocados em movimento. Finaliza-se detenco considerações sobre as posibilidades de potencia da educação infantil em romper desde cedo os discursos binários e heternormativos sobre gêneros e sexualidades.

Pretende-se discorrer sobre a efetivação do direito fundamental à saúde por meio de decisões do Poder Judiciário no Estado Contemporâneo. Para tanto, serão apresentados instrumentos jurídicos com os quais é possível a fruição de tais direitos de forma eficiente, tal como determina a Constituição da República Federativa do Brasil. A necessidade e importância desse estudo se devem à progressiva busca para a efetivação dos direitos sociais, contribuindo para aprimoramento dos estudos relacionados aos direitos fundamentais.

There is a large volume of work in Information Science addressing organizational context and complex social situations. These contexts, composed of heterogeneous elements, such as people, processes, cultures and the like, are difficult to understand using quantitative methods. Some Information Science researchers are using the Soft Systems Methodology to understand how information and knowledge systemically aggregate elements of these contexts, elucidating gaps and proposing solutions. This methodology is based on a dialog between subjects involved in the problematic situation for a holistic understanding of it. Being non-prescriptive, the methodology in question provides guidelines, but allows flexibility as to the mode and scope of application. Thus, it aims to investigate the use of the methodology aforementioned in theses of the Information Science programs best rated by the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior, highlighting correlations in these works between the Soft Systems Methodology and various fields of Science Information. Therefore, the scope study method is used to perform a bibliographic mapping. As a result, it was found that the methodology considered is used in conjunction with the most diverse themes, both those focused on management, as well as more traditional ones, such as documentation, with a growth potential for their employment, as it adapts well to different types of research, especially those that consider reality as a complex social system., Verifica-se a existência de um grande volume de trabalhos em Ciência da Informação que abordam o contexto organizacional e situações sociais complexas. Argumenta-se que nesses contextos, compostos de elementos heterogêneos, como pessoas, processos, culturas e afins, é difícil traçar um panorama utilizando-se de métodos quantitativos tradicionais. Alguns pesquisadores da Ciência da Informação estão utilizando a Metodologia de Sistemas Soft para compreender como a informação e o conhecimento aglutinam de modo sistêmico os elementos desses contextos, elucidando lacunas e propondo soluções. Essa metodologia se baseia justamente no debate entre sujeitos envolvidos na situação problemática para uma compreensão holística da mesma. Sendo não-prescritiva, a metodologia em questão traz diretrizes, mas permite flexibilidade quanto ao modo e âmbito de aplicação. Portanto, objetiva-se investigar o uso da metodologia já referida em teses dos programas de Ciência da Informação melhor avaliados pela Coordenação de Aperfeiçoamento de Pessoal de Nível superior, destacando as correlações feitas nesses trabalhos entre a Metodologia de Sistemas Soft e os diversos campos da Ciência da Informação. Para tanto, utiliza-se o método de estudo de escopo para realização de um mapeamento bibliográfico. Como resultados, apurou-se que se emprega a metodologia considerada em conjunção com os temas mais diversos, tanto os voltados à gestão, como os mais tradicionais, como a documentação, havendo um potencial de crescimento para o seu emprego, visto adaptar-se bem a diversos tipos de pesquisa, em especial as que consideram a realidade como um sistema social complexo.

A new genus and a new species of Eulimidae are described based on the shell morphology and on the host-parasite relationship of the type species. Eulimacrostoma microsculpturata Souza & Pimenta gen. nov. and sp. nov. parasitizes a starfish of the genus Luidia and has an elongated, conical, straight, or slightly curved shell, a protoconch with a brownish spiral band and convex whorls, a peculiar large and broad aperture with a strongly protruding outer lip, and microsculpture of axial lines on the teleoconch. Four other species are included in the genus, all from the western Atlantic: Eulimacrostoma chascanon (Watson, 1883), comb. nov., Eulimacrostoma fusus (Dall, 1889), comb. nov., Eulimacrostoma lutescens (Simone, 2002), comb. nov., and Eulimacrostoma patula (Dall & Simpson, 1901), comb. nov. Newly available material of Eulimacrostoma patula expands the known geographic distribution of this species in the Caribbean to the north coast of Brazil. Eulimacrostoma chascanon and Eulimacrostoma fusus and Eulimacrostoma lutescens are known only by the type series which was re-examined. A redescription is provided for Eulimacrostoma chascanon and Eulimacrostoma fusus. Species within Eulimacrostoma differ mainly by teleoconch sculpture, the presence or absence of an umbilical fissure, and shell dimensions. Lectotypes are designated for Eulimacrostoma chascanon, Eulimacrostoma fusus, and Eulimacrostoma patula.

Item does not contain fulltext, Global warming may intensify eutrophication of shallow lakes by affecting nutrient loading, evaporation rates, and water level and thus produce major changes in food webs. We investigated to what degree food webs in tropical humid lakes differed from those in more eutrophic semi-arid lakes of the same latitude. Our results indicate that the catchment area-to-lake area ratio, nutrients, chlorophyll a, suspended solids, abundances of phytoplankton, zooplankton, and omnivorous fish as well as total fish catch per unit effort were all higher in the semi-arid lakes, whereas inlet water-to-evaporation ratio (proxy for water balance), water transparency, percentage macrophytes cover, and the piscivores:omnivores ratio were higher in the humid lakes. Our results suggest that reduced inlet water-to-evaporation ratio will increase lake eutrophication, which, in turn, as in temperate regions, will alter trophic structure of the freshwater community.