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The article cites a study which states that circulating CD26 is negatively associated with inflammation in human and experimental arthritis. Researcher N. Busso and colleagues explained that dipeptidyl peptidase IV, a protease-cleaving N-terminal X-Pro dipeptide from selected proteins including some chemokines, is expressed both as a soluble form in plasma and on the cell surface of various immune and non-immune cell types. Busso and colleagues published their study in the "American Journal of Pathology."

The article cites a study on arthritic inflammation, by N. Busso and colleagues, and published in the "American Journal of Pathology." According to a study, circulating CD26 is negatively associated with inflammation in human and experimental arthritis. Dipeptidyl peptidase IV, a protease-cleaving N-terminal X-Pro dipeptide from selected proteins including some chemokines, is expressed both as a soluble form in plasma and on the cell surface of various immune and nonimmune cell types. Decreased circulating CD26 levels in arthritis may influence CD26- mediated regulation of the chemotactic SDF-1/CXCR4 axis.