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The article focuses on the environmental impact of veterinary medicines and the challenges veterinarians face in disposing of them safely. Topics include the effects of pharmaceuticals on wildlife, the lack of clear guidelines for disposal, and the role of veterinarians in preventing contamination of ecosystems.

The article focuses on key considerations for setting up a new veterinary practice, emphasizing the importance of a clear business plan and securing funding. Topics include selecting the right location, choosing the business structure, and managing costs such as equipment and staffing. The article also highlights the need for financial projections and the benefits of professional support throughout the process.

The Reserve Bank of Australia (RBA) has a damaged banknote claims service that allows individuals and institutions to submit claims for damaged banknotes. Between 2014 and 2021, the RBA processed around 110,000 claims, resulting in approximately $44 million in payments. The most common types of damage are ripped and torn notes, followed by heat-affected and environmentally impacted notes. Natural disasters, such as floods and bushfires, have led to some of the largest claims by dollar value. The RBA uses various methods, including chemical analysis, to assess the value of extensively damaged notes. [Extracted from the article]

A study conducted at Jordan University of Science and Technology evaluated the risk factors associated with selected elements in veterinary active pharmaceutical ingredients (V APIs) using inductively coupled plasma mass spectrometry (ICP-MS). The research found that the concentrations of essential and non-essential elements in V APIs were below permissible limits recommended by the United States Pharmacopeia. The study concluded that the elements do not pose any risk to animals based on the target hazard quotient values. The research was peer-reviewed and conducted by Adnan M. Massadeh, Waad E. Abu Diak, and Hamza A. Massadeh. [Extracted from the article]

Researchers at Universitas Muhammadiyah Surakarta in Indonesia conducted a study exploring the aphrodisiac properties of certain Indonesian herbal plants on male rats. The study involved extracting compounds from plants like Piper retrofractum and Watermelon albedo, and testing their effects on mating frequency and testicular health. The findings suggested that Solanum melongena fruit extract had the most significant aphrodisiac effects, while Piper retrofractum extract showed similarities to sildenafil in terms of testicular weight impact. This research provides valuable insights into the potential use of herbal plants in enhancing male libido and reproductive health. [Extracted from the article]

Researchers from Biopharm have conducted a study to provide a detailed physicochemical characterization of the oral biotherapeutic drug IMUNOR. IMUNOR is a dialyzable leukocyte extract (DLE) prepared from swine leukocytes and has been used for the treatment of immunodeficiencies, allergies, and bacterial infections. The researchers developed various methods to analyze the composition and variability of IMUNOR, including spectrophotometric and chromatographic techniques. The study confirmed the batch-to-batch reproducibility of IMUNOR, providing valuable insights into its physicochemical properties. For more information, readers can refer to the original research article published in Pharmaceuticals. [Extracted from the article]

A report from Beni-Suef University in Egypt discusses the analysis of a binary mixture of oxytetracycline (OTC) and bromohexine (BR) in their combined veterinary formulation. The researchers developed four spectrophotometric methods for determining the concentrations of OTC and BR in the mixture. These methods were found to be precise, rapid, and simple, and they were validated according to ICH guidelines. The researchers also assessed the "greenness" of the methods, using various metrics to evaluate their impact on health and the environment. The methods were found to be highly selective, robust, and precise, and they can be used in any analytical laboratory. [Extracted from the article]

Swedish online pharmacy Apotea AB is reportedly considering an initial public offering (IPO) in Sweden, with the potential to raise $200 million to $300 million. The company is working with advisers, including Carnegie Bank A/S, on the preparations for the IPO. European IPOs have been on the rise this year, with companies in the region raising over $18 billion through first-time share sales. Apotea, founded in 2011, is one of Sweden's largest online pharmacies, offering a range of products and medical advice. [Extracted from the article]

The U.S. Food and Drug Administration (FDA) has provided a summary of recent news from the agency. The FDA and NIH will be holding a joint public meeting on advancing smoking cessation products. The FDA has also approved Zenrelia, a new animal drug for controlling itching and allergies in dogs. Additionally, the FDA has approved Rybrevant for the treatment of non-small cell lung cancer, and Kisqali and Keytruda for the treatment of breast cancer and malignant pleural mesothelioma, respectively. The FDA's Center for Veterinary Medicine is conducting a SWOT analysis to research challenges in the animal health industry, and has established Animal and Veterinary Innovation Centers to support animal health and veterinary interventions. The FDA has also updated an outbreak advisory for Diamond Shruumz-Brand Chocolate Bars, Cones, & Gummies, and has provided full prescribing information for the approved drugs on Drugs@FDA. [Extracted from the article]

The U.S. Food and Drug Administration (FDA) has approved FluMist, a nasal spray influenza vaccine, for self- or caregiver-administration. This vaccine is used to prevent influenza disease caused by influenza virus subtypes A and B in individuals aged 2 to 49 years. FluMist is the first vaccine for the flu that does not need to be administered by a healthcare provider. The FDA's approval provides a new option for receiving a safe and effective seasonal influenza vaccine with greater convenience and accessibility. The flu can cause mild to severe illness and serious complications, so getting vaccinated each year is important. FluMist contains weakened live influenza virus strains and is sprayed into the nose. The most commonly reported side effects are fever, runny nose, nasal congestion, and sore throat. FluMist can be obtained through a third-party online pharmacy for self- or caregiver-administration. A study was conducted to ensure that recipients and caregivers can safely and effectively use the vaccine. The FDA granted approval to MedImmune LLC for FluMist. [Extracted from the article]

A recent study conducted by researchers from the Ministry of Agriculture and Rural Affairs has revealed new findings on antibiotics, specifically focusing on a pleuromutilin compound called PMTM. The study found that PMTM demonstrated high antibacterial efficacy against methicillin-resistant Staphylococcus aureus (MRSA) infections, with limited potential for resistance development. Additionally, PMTM showed low cytotoxicity, tolerable acute toxic effects, and improved pharmacokinetics properties. These results provide a solid foundation for the development of PMTM as a potential new antibacterial drug. [Extracted from the article]

A study conducted by researchers at the University of Verona in Italy explores the use of liquid chromatography-mass spectrometry (LC-MS) in analyzing chemical contaminants in food. The study reviews the methodologies used for determining veterinary drugs and pesticides in food and discusses the strengths and limitations of LC-MS screening methods. The research provides prospective directions for advancing LC-MS methodologies in this field. The study has been peer-reviewed and is available for further information. [Extracted from the article]

A recent study published in Veterinary Week discusses the use of drug repositioning as a complementary approach to traditional drug innovation in both human and veterinary medicine. The study highlights the potential benefits of drug repositioning, such as shorter development timelines and reduced costs. However, it also notes that drug repositioning is currently underutilized in veterinary applications. The researchers propose the establishment of a "One Health Drug Repositioning Platform" to facilitate closer cooperation between stakeholders and promote the integration of human and veterinary drug repositioning. The study also reviews the use of COX inhibitors for treating dog cancers as an example of veterinary drug repositioning. [Extracted from the article]

A report from South China Agricultural University discusses the preparation of altrenogest soft capsules and their bioequivalence in gilts. Altrenogest is commonly used to regulate the estrous cycle of sows and mares, but current oral solutions have issues with dose accuracy and stability. The researchers aimed to create softgel capsules with a unit dose equal to the clinically administered dose. The capsules were found to have higher content, accurate dosing, good stability, and were bioequivalent to the oral solution, making them suitable for clinical use. [Extracted from the article]

The U.S. Food and Drug Administration (FDA) has issued a draft guidance for conducting multiregional clinical trials (MRCT) in oncology. The FDA encourages sponsors to pursue MRCTs but emphasizes that these trials should be conducted within the appropriate context. The draft guidance aims to improve the planning, design, conduct, and analysis of future oncology MRCTs, ensuring that the data generated from these trials is applicable to patients in the United States and aligns with current standards of oncological care. The FDA is accepting comments on the draft guidance for 60 days after its publication in the Federal Register. [Extracted from the article]

A study conducted by researchers at Zhengzhou University of Light Industry in China developed a modified method for the determination of multiple pesticides and veterinary drugs in honey. The researchers used silanized melamine sponges coupled with ultra-high liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) for quick and convenient matrix separation. The results showed satisfactory matrix purification performance of the silanized melamine sponges, indicating their potential application in the determination of pesticides and veterinary drugs in various foods. The study was funded by the National Natural Science Foundation of China and other organizations. [Extracted from the article]

A study conducted by the University of California Davis in the United States aimed to determine the withdrawal interval (WDI) for pheasants after the administration of fenbendazole medicated feed. The researchers analyzed the pharmacokinetic and residue depletion profile of fenbendazole and its metabolites in liver and muscle samples. The study concluded that fenbendazole sulfoxide (FBZ-SO2) can be used as the marker residue in the liver of pheasants, and recommended a withdrawal interval of 7 days for FBZ-SO2 in pectoral muscle. The research was supported by the Minor Use Animal Drug Program and the United States Department of Agriculture. [Extracted from the article]

A report from the Ministry of Health in Rome, Italy discusses the importance of animal welfare in the context of the one health approach, which recognizes the interdependence of human, animal, and plant health. The report specifically focuses on the welfare of animals during transport, highlighting the stress and discomfort they experience. While there have been improvements in animal welfare standards during transportation, there are still pressing issues in current European Union legislation that need to be addressed. The report provides a summary of the history and current status of this complex issue. [Extracted from the article]

Researchers from Beni Suef University in Egypt have developed an eco-friendly method for simultaneously detecting the residues of three veterinary drugs (erythromycin, sulfadiazine, and trimethoprim) in edible chicken tissues. The method, which uses ultra-performance liquid chromatography-tandem mass spectrometry (UPLC/MS/MS), was validated according to FDA guidelines and found to be sensitive, selective, and efficient. The researchers also assessed the environmental impact of the method using green metric systems and found it to have a low environmental impact. This method can be used to ensure human safety and maintain public health by testing for the presence of these drug residues in marketed meat samples. [Extracted from the article]

Elanco Animal Health has announced that the U.S. Food and Drug Administration (FDA) has completed its review of all major and minor technical sections for Credelio Quattro, a new animal drug. The final 60-day administrative review is now underway. Elanco expects to launch Credelio Quattro in the first quarter of 2025, pending FDA approval. The drug is seeking approval for indications that would provide broad parasite coverage for fleas, ticks, heartworms, and other internal parasites. Elanco also anticipates significant sales from its innovation portfolio in the coming years. [Extracted from the article]

This article discusses the importance of pets in the White House throughout history. It highlights some of the pets owned by past presidents, such as George Washington, John Tyler, Abraham Lincoln, and Franklin D. Roosevelt. The article also emphasizes the role of veterinary professionals in providing care for these pets and the significance of the veterinary profession in general. It concludes by emphasizing the importance of providing excellent care to all animals, both in the White House and in clients' homes. [Extracted from the article]

The article provides an overview of recent U.S. Food and Drug Administration (FDA) activities as of August 13, 2024. Topics discussed include warning letters issued to companies for marketing unapproved animal drugs, the announcement of a public meeting on advancing rare disease therapies, and the approval of a new drug for treating hypoparathyroidism.

A recent study conducted by researchers at North-West University in Potchefstroom, South Africa, has found that goat milk in the Mahikeng Local Municipality is highly contaminated with antibiotic residues. The study involved interviews with 100 goat farmers and the analysis of raw milk samples from 266 goats. The results showed that antibiotic residues, including erythromycin, sulfamethazine, and amoxicillin, exceeded the maximum residue levels in a significant percentage of the samples. The researchers concluded that this contamination poses a health risk to consumers. [Extracted from the article]

A report from Washington State University discusses the efficacy of buparvaquone in treating sub-clinically infected cattle with the Ikeda genotype of Theileria orientalis, a tick-borne hemoparasite. The study found that buparvaquone had a transient effect on parasitemia, with parasites remaining undetectable in peripheral blood for several weeks post-treatment. However, there was a relapse of parasitemia after treatment, and the drug did not effectively clear the infection. The researchers suggest that further investigations are needed to develop comprehensive control measures for this parasite. [Extracted from the article]

A report from the University of Gondar in Ethiopia discusses the findings of a study on the dissolution profiles of different brands of albendazole boluses, a type of veterinary drug. The study found that none of the six brands tested met the requirements of the dissolution test, indicating potential issues with their therapeutic efficacy. However, all five brands were comparable to the comparator products in terms of similarity factor. The study highlights the need for national in-vitro dissolution studies to improve quality control and ensure veterinary pharmaceuticals meet safety and efficacy standards. [Extracted from the article]

A recent study conducted by researchers at Hunan Normal University in China has discovered a potential therapeutic strategy for cervical cancer. The study found that inhibiting the SLC7A11/xCT axis, which is crucial for maintaining the synthesis of glutathione and the antioxidant system in cervical cancer cells, could be an effective treatment. Through in silico and in vitro experiments, the researchers discovered a compound called compound 1 that targets the SLC7A11/xCT axis and induces cell death in cervical cancer cells. The results suggest that compound 1 has potential as a treatment for cervical cancer. [Extracted from the article]

A recent study conducted by researchers at Capital Medical University in Beijing, China, examined the optical coherence tomography (OCT) findings of presumed veterinary anthelmintic-induced retinal toxicity. The study found that diffuse hyperreflective lesions in the outer retina were observed, particularly in the mitochondria-enriched ellipsoid zone, suggesting that these drugs may cause retinal damage by affecting mitochondrial energy metabolism. The research highlights the potential harm that certain veterinary anthelmintic drugs can have on the human retina if overdosed, leading to visual disturbances. The study provides valuable insights into the pathogenic mechanisms of retinal toxicity caused by these medications. [Extracted from the article]

A recent study conducted by Chung Ang University in Seoul, South Korea, focused on the validation of analytical methods for detecting veterinary drug residues in livestock and fishery products. The study aimed to address the potential risks to food safety and human health posed by the residues of veterinary drugs in animal products. The researchers validated two methods for quantifying these residues, which exhibited excellent linearity, recoveries, and low limits of detection and quantification. This study is significant as it contributes to the limited research available on the analysis of veterinary drug residues in livestock and fishery products. [Extracted from the article]

The article focuses on a summary of recent updates from the FDA (U.S. Food and Drug Administration) as of August 2, 2024. Topics include the FDA's efforts to advance clinical trial diversity for LGBTQIA communities, the approval and updates related to various medical products and devices, and new initiatives and safety alerts issued by the agency.

The article focuses on the FDA (U.S. Food and Drug Administration) approving Zurnai, the first nalmefene hydrochloride auto-injector for reversing opioid overdose. Topics include the details of the drug's approval, its role in the FDA's Overdose Prevention Framework, and the FDA's efforts to address the opioid crisis.

A recent study conducted by the University of Brasilia has developed a new device called the OphthalMimic, which aims to improve the evaluation of ophthalmic drug products while reducing the need for animal testing. The device is a 3D-printed model that closely mimics human ocular conditions and can be used for dissolution/release tests. The researchers also developed a hydrogel-based hybrid membrane to simulate the cornea, which showed promising results in terms of water content and morphological analysis. This advancement in ophthalmic drug evaluation aligns with the ethical mandate to reduce animal testing and has the potential to accelerate the development of safer and more effective drugs. [Extracted from the article]

A study conducted at the State University of New Jersey has investigated the impact of a Pgp inhibitor called tariquidar on the exposure of ondansetron, a drug used for neuropathic pain treatment, in the central nervous system (CNS). The study found that tariquidar administration resulted in a complete inhibition of ondansetron efflux in the brain and spinal cord. The research provides important quantitative information on enhancing CNS exposure to ondansetron and suggests that tariquidar co-administration could result in comparable CNS exposure to that observed in rats without Pgp. The study also highlighted the effect of tariquidar on the plasma disposition of ondansetron, which may not be dependent on Pgp inhibition. [Extracted from the article]

Novo Holdings, an international life sciences investor, has announced that its portfolio company, Invetx, will be acquired by Dechra Pharmaceuticals for up to $520 million. Invetx specializes in developing protein-based animal health therapeutics to improve veterinary care. Novo Holdings has been a supporter of Invetx and this acquisition reflects their commitment to investing in innovative life sciences companies. The CEO of Invetx expressed gratitude for Novo Holdings' support and excitement for the partnership with Dechra Pharmaceuticals. [Extracted from the article]

The U.S. Food and Drug Administration (FDA) has issued several updates and announcements. They have notified healthcare providers about interruptions in the supply of BD BACTEC blood culture media bottles and recommended strategies to conserve their use. The FDA has also announced a webinar on compliance with medical device reporting requirements and issued final guidance for studies of devices intended to treat opioid use disorder. Additionally, the FDA has approved the first generic methimazole oral solution for the treatment of hyperthyroidism in cats and updated advisories for illnesses linked to Diamond Shruumz-brand products and bulk organic walnuts. [Extracted from the article]

The protozoan could be a promising new way to safely and effectively get drugs across the blood-brain barrier. [ABSTRACT FROM AUTHOR]

A recent report from the China Institute of Veterinary Drug Control discusses the potential antiviral activity of luteolin against the porcine epidemic diarrhea virus (PEDV). The study found that luteolin, a flavonoid, demonstrated anti-viral effects in PEDV-infected cells and inhibited the internalization, replication, and release of the virus. Additionally, luteolin was found to bind to human ACE2 and the SARS-CoV-2 main protease, suggesting its potential for viral entry inhibition. However, the study also identified the emergence of a drug-resistant mutant after multiple passages, indicating reduced susceptibility to luteolin. These findings contribute to the understanding of anti-PEDV mechanisms and the potential use of luteolin in combating PEDV. [Extracted from the article]

A recent study conducted by researchers from Wageningen Food Safety Research examined the transfer of veterinary drugs from substrate to black soldier fly larvae. The study aimed to evaluate the safety of using insects as feed and food in Europe, particularly when organic substrates or residual streams like manure are used. The researchers found that certain veterinary drugs, such as oxytetracycline and eprinomectin, had negative effects on the weight and survival of the larvae. However, the larvae seemed to metabolize the drugs, and their metabolites were detected in the larvae and frass. The study suggests that insect-rearing substrates should be assessed for veterinary drug residues to ensure feed and food safety and to understand their potential impact on insect growth. [Extracted from the article]

The U.S. Food and Drug Administration (FDA) has issued an update on several topics. They have recalled Diamond Shruumz-brand Chocolate Bars, Cones, and Gummies due to illnesses. The FDA has also provided guidance on drug delivery devices and addressed men's health concerns. They have seized unauthorized e-cigarette products and announced a partnership for breath-based diagnostic devices. The FDA has granted accelerated approval for a treatment for follicular lymphoma. The agency is responsible for ensuring the safety of various products, but no further details are provided. For more information, readers can contact the FDA Office of Media Affairs or the FDA Consumer hotline. [Extracted from the article]

A study conducted in Vietnam examined the implementation of regulations aimed at reducing antibiotic use in livestock production. The study found that while there have been efforts to strengthen the regulatory framework, the level of implementation of these measures remains unknown. The researchers identified 10 factors that could influence the implementation of these regulations, including stakeholder perception, knowledge, technical guidance, economic interests, and technical and financial barriers. The study emphasized the need for greater involvement of local stakeholders in the development of regulations and the mainstreaming of innovations developed by small producers. [Extracted from the article]

A recent study conducted by the University of Guelph in Canada evaluated a sedation drug protocol for injured or ill raccoons to improve their welfare during transport and euthanasia. The study found that the combination of acepromazine, alfaxalone, and medetomidine provided acceptable sedation and analgesia for the raccoons. The research aimed to address concerns about the handling, transportation, and delays before euthanasia of raccoons, and the findings suggest that this drug protocol can help improve the process. The study was peer-reviewed and published in the Canadian Veterinary Journal. [Extracted from the article]

A recent report from the University of Vienna discusses the challenges of characterizing the "exposome," or the various food-related and environmental contaminants that humans are exposed to. The researchers aimed to expand a previously established method for biomonitoring these contaminants by incorporating veterinary drugs and pesticides. The study successfully validated the expanded method, which can now detect and quantify over 120 diverse analytes in a single analytical run. This research demonstrates the potential to expand targeted multianalyte methods to include additional groups of potentially toxic chemicals. [Extracted from the article]

A recent study conducted by researchers at Poznan University of Life Sciences in Poland compared two electroanalytical systems for detecting the fluoroquinolone antibiotic danofloxacin (DANO). The study aimed to determine the optimal conditions for detecting DANO and extract electroanalytical parameters. The researchers found that the electrified liquid-liquid interface (eLLI) system provided better electroanalytical parameters and good selectivity when analyzing milk samples. This study is the first to directly compare the electroanalytical parameters obtained with a solid electrode and eLLI. The research was supported by the National Science Center in Cracow, Poland. [Extracted from the article]

The U.S. Food and Drug Administration (FDA) has released a summary of recent news and actions. The FDA is seeking input on patient safety related to certain medical software functions, issuing a warning letter to Dollar Tree Inc. for failing to remove recalled products from store shelves, approving the vaccine Capvaxive for the prevention of Streptococcus pneumoniae infections, announcing educational conferences on the new animal drug approval process, publishing a blog on the potential of artificial intelligence in healthcare, and approving various medications for different conditions. The FDA's goal is to ensure the safety and effectiveness of drugs, medical devices, and other products. [Extracted from the article]