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2. Metal Methanesulfonates with Mixed Anionic Groups with Large Band Gaps and Enhanced Birefringence

Author

Liang, Mingli, Zhang, Yujie, Izvarin, Eugene, Waters, Michael J., Rondinelli, James M., and Halasyamani, P. Shiv

Abstract

Four new metal methanesulfonates with mixed anionic groups, Bi(SeO3)(CH3SO3) (1), Bi(TeO3)(CH3SO3) (2), Ba(BF4)(CH3SO3) (3), and Ba2(BF4)(CH3SO3)3(H2O)3(4), have been successfully synthesized. Compounds 1and 2are isomorphic and exhibit a two-dimensional (2D) layered structure. Stereoactive lone pairs are observed with Se4+, Te4+, and Bi3+. Compound 3features a three-dimensional (3D) structure formed by connecting [Ba(CH3SO3)]+layers via BF4tetrahedra, whereas compound 4features a 2D layered structure, where the BF4tetrahedra are positioned on both sides of the [Ba2(CH3SO3)3]+layers. The ultraviolet–visible–near-infrared (UV–vis-NIR) spectra indicate that compounds 1and 2have absorption edges at 270 and 274 nm, whereas compounds 3and 4, with absorption edges below 200 nm, are characterized as deep-UV crystals. Calculations were performed to determine the absorption edges, and comparative analysis indicates a significant enhancement in the calculated birefringence values compared to analogous compounds.

Published
2024
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3. The Download The data center on the third floor In pursuit of speed, more and more server farms are winding their way into cities

Author

Waters, Michael

Subjects
File servers -- Usage, Computer services industry -- Buildings and facilities, Computer services industry, Business, Computers and office automation industries, High technology industry
Abstract

In 1930, the telegraph giant Western Union put the finishing touches on its new crown jewel: a 24-story art deco building located at 60 Hudson Street in lower Manhattan. Soon [...]

Published
2022

4. Rb2Sn4Q9(Q = S and Se): Low-Dimensional Noncentrosymmetric Chalcogenides with High Laser-Induced Damage Threshold

Author

Iyer, Abishek K., Ha, Seung Heon, Waters, Michael J., Ie, Thomas S., Shin, Seung Han, Rondinelli, James M., Jang, J. I., and Kanatzidis, Mercouri G.

Abstract

Low-dimensional chalcogenides have shown promising nonlinear optical (NLO) responses in the infrared region. Rb2Sn4Q9(Q = S and Se) crystallizes in the noncentrosymmetric orthorhombic space group P212121. These compounds comprise an anionic layer of [Sn4Q9]2–chains separated by the Rb atoms located between the layers. Differential thermal analysis shows that Rb2Sn4Se9melts congruently, having a melting point temperature of 472 °C and a crystallization temperature of 443 °C and no observable phase transitions, making them promising for large crystal growth. These compounds’ air- and water-stability make them more viable for application compared to the challenges faced in other promising NLO materials like γ-NaAsSe2. The Rb2Sn4S9and Rb2Sn4Se9have energy band gaps of 2.56 and 1.75 eV, respectively. Second harmonic generation from Rb2Sn4Q9was found to be nonphase matchable for particle size above 75 μm, with Rb2Sn4Se9having a χ(2)= 36.7 ± 7.4 pm/V at 1800 nm. Both materials show a high laser-induced damage threshold (LIDT) of 1.8 GW/cm2and 0.2 GW/cm2for the sulfide and selenide compounds, respectively, which are significantly larger than that of the benchmark reference material, AgGaSe2(0.1 GW/cm2). The high LIDT values make these materials promising for NLO applications involving intense light–matter interactions..

Published
2023
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5. Sinnerman

Author

Waters, Michael

Subjects
Philosophy and religion
Abstract

Oh, sinnerman, where you gonna run to? --traditional African American spiritual First you see only shadows, sable bristles Stippling the silty, ribbed floor, then Glimpse the suspended apparitions. Pencil-long, glassine [...]

Published
2022

7. Roles of Growth Hormone–Dependent JAK-STAT5 and Lyn Kinase Signaling in Determining Lifespan and Cancer Incidence

Author

Chhabra, Yash, Bielefeldt-Ohmann, Helle, Brooks, Tania Louise, Brooks, Andrew James, and Waters, Michael J

Abstract

In rodents, loss of growth hormone (GH) or its receptor is associated with extended lifespan. We aimed to determine the signaling process resulting in this longevity using GH receptor (GHR)-mutant mice with key signaling pathways deleted and correlate this with cancer incidence and expression of genes associated with longevity. GHR uses both canonical janus kinase (JAK)2-signal transducer and activator of transcription (STAT) signaling as well as signaling via the LYN-ERK1/2 pathway. We used C57BL/6 mice with loss of key receptor tyrosines and truncation resulting in 1) loss of most STAT5 response to GH; 2) total inability to generate STAT5 to GH; 3) loss of Box1 to prevent activation of JAK2 but not LYN kinase; or 4) total knockout of the receptor. For each mutant we analyzed lifespan, histopathology to determine likely cause of death, and hepatic gene and protein expression. The extended lifespan is evident in the Box1-mutant males (retains Lyn activation), which have a median lifespan of 1016 days compared to 890 days for the Ghr−/−males. In the females, GhrBox1−/−mice have a median lifespan of 970 days compared to 911 days for the knockout females. Sexually dimorphic GHR-STAT5 is repressive for longevity, since its removal results in a median lifespan of 1003 days in females compared to 734 days for wild-type females. Numerous transcripts related to insulin sensitivity, oxidative stress response, and mitochondrial function are regulated by GHR-STAT5; however, LYN-responsive genes involve DNA repair, cell cycle control, and anti-inflammatory response. There appears to be a yin-yang relationship between JAK2 and LYN that determines lifespan.

Published
2024
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8. An Overlooked Path to a Financial Fresh Start.

Author

Waters, Michael

Subjects
*BANKRUPTCY, *DEBT, *WEALTH inequality, *AMERICANS
Abstract

Bankruptcy could help many Americans forgive their debts—yet few take advantage of it. [ABSTRACT FROM AUTHOR]

Published
2024

9. Interventional Treatment of Vascular Anomalies

Author

Waters, Michael J., Hinshelwood, Jonathan, and Chaudry, M. Imran

Abstract

Vascular anomalies are highly variable in their angioarchitecture, location, and flow dynamics. An individualized, multidisciplinary approach to treatment is required, focusing on improving patient quality of life. With appropriate percutaneous or endovascular treatment, patient satisfaction following interventional therapy is generally high, acknowledging that a complete cure may not always be possible.

Published
2022
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10. Tixagevimab–cilgavimab for treatment of patients hospitalised with COVID-19: a randomised, double-blind, phase 3 trial

Author

Ginde, Adit A., Paredes, Roger, Murray, Thomas A., Engen, Nicole, Grandits, Greg, Vekstein, Andrew, Ivey, Noel, Mourad, Ahmad, Sandkovsky, Uriel, Gottlieb, Robert L., Berhe, Mezgebe, Jain, Mamta K., Marines-Price, Rubria, Agbor Agbor, Barbine Tchamba, Mateu, Lourdes, España-Cueto, Sergio, Lladós, Gemma, Mylonakis, Eleftherios, Rogers, Ralph, Shehadeh, Fadi, Filbin, Michael R., Hibbert, Kathryn A., Kim, Kami, Tran, Thanh, Morris, Peter E., Cassity, Evan P., Trautner, Barbara, Pandit, Lavannya M., Knowlton, Kirk U., Leither, Lindsay, Matthay, Michael A., Rogers, Angela J., Drake, Wonder, Jones, Beatrice, Poulakou, Garyfallia, Syrigos, Konstantinos N., Fernández-Cruz, Eduardo, Natale, Marisa Di, Almasri, Eyad, Balerdi-Sarasola, Leire, Bhagani, Sanjay R., Boyle, Katherine L., Casey, Jonathan D., Chen, Peter, Douin, David J., Files, D. Clark, Günthard, Huldrych F., Hite, R. Duncan, Hyzy, Robert C., Khan, Akram, Kibirige, Moses, Kidega, Robert, Kiweewa, Francis, Jensen, Jens-Ulrik, Leshnower, Bradley G., Lutaakome, Joseph K., Manian, Prasad, Menon, Vidya, Morales-Rull, Jose Luis, O'Mahony, D. Shane, Overcash, J. Scott, Ramachandruni, Srikant, Steingrub, Jay S., Taha, Hassan S., Waters, Michael, Young, Barnaby E., Phillips, Andrew N., Murray, Daniel D., Jensen, Tomas O., Padilla, Maria L., Sahner, David, Shaw-Saliba, Katy, Dewar, Robin L., Teitelbaum, Marc, Natarajan, Ven, Rehman, M. Tauseef, Pett, Sarah, Hudson, Fleur, Touloumi, Giota, Brown, Samuel M., Self, Wesley H., Chang, Christina C., Sánchez, Adriana, Weintrob, Amy C., Hatlen, Timothy, Grund, Birgit, Sharma, Shweta, Reilly, Cavan S., Garbes, Pedro, Esser, Mark T., Templeton, Alison, Babiker, Abdel G., Davey, Victoria J., Gelijns, Annetine C., Higgs, Elizabeth S., Kan, Virginia, Matthews, Gail, Thompson, B. Taylor, Neaton, James D., Lane, H. Clifford, and Lundgren, Jens D.

Abstract

Tixagevimab–cilgavimab is a neutralising monoclonal antibody combination hypothesised to improve outcomes for patients hospitalised with COVID-19. We aimed to compare tixagevimab–cilgavimab versus placebo, in patients receiving remdesivir and other standard care.

Published
2022
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11. Paralegal Precedent.

Author

Waters, Michael

Subjects
*SIMPSONS (Fictional characters), *FICTIONAL characters, *CLEAN energy, *RENEWABLE energy sources
Abstract

The article discusses Colonial America, lawyers were regarded with intense skepticism. Rather than arbiters of public disputes, they were seen as rabble-rousers who had a financial interest in escalating arguments. For instance, the Colony of Connecticut complained in 1729 that "many persons of late have taken upon them to be attorneys at the bar, so that quarrels and lawsuits are multiplied.

Published
2022

12. Eaten by beauty

Author

Waters, Michael

Subjects
Philosophy and religion
Abstract

Eaten by beauty Dominican Republic The yellow-crowned night heron Plucks the land crab Inching from its burrow, Cracks its red shell To pick with whetted beak The shredded innards. The [...]

Published
2021

13. Carrot

Author

Waters, Michael

Subjects
Philosophy and religion
Abstract

'Blessed be sin if it teaches men shame.' --Georges Bernanos, The Diary of a Country Priest Carrot This clod-caked taproot tugged from soil Then rinsed in water clear & cool [...]

Published
2021

14. Endovascular thrombectomy versus standard bridging thrombolytic with endovascular thrombectomy within 4·5 h of stroke onset: an open-label, blinded-endpoint, randomised non-inferiority trial

Author

Mitchell, Peter J, Yan, Bernard, Churilov, Leonid, Dowling, Richard J, Bush, Steven J, Bivard, Andrew, Huo, Xiao Chuan, Wang, Guoqing, Zhang, Shi Yong, Ton, Mai Duy, Cordato, Dennis J, Kleinig, Timothy J, Ma, Henry, Chandra, Ronil V, Brown, Helen, Campbell, Bruce C V, Cheung, Andrew K, Steinfort, Brendan, Scroop, Rebecca, Redmond, Kendal, Miteff, Ferdinand, Liu, Yan, Duc, Dang Phuc, Rice, Hal, Parsons, Mark W, Wu, Teddy Y, Nguyen, Huy-Thang, Donnan, Geoffrey A, Miao, Zhong Rong, Davis, Stephen M, Desmond, Patricia, Yassi, Nawaf, Zhao, Henry, Williams, Cameron, Alemseged, Fana, Ng, Felix C, Yogendrakumar, Vignan, Bailey, Peter, De Villiers, Laetitia, Phan, Thanh, Thirugnanachandran, Tharani, Chong, Winston, Asadi, Hamed, Slater, Lee Anne, Manning, Nathan, Wenderoth, Jason, McDougall, Alan, Williams, Cameron, Cappelen-Smith, Cecilia, Whitley, Justin, Edwards, Leon, Esperon, Carlos Garcia, Spratt, Neil, Pepper, Elizabeth, Levi, Chris, Faulder, Ken, Harrington, Timothy, Krause, Martin, Waters, Michael, Fink, John, Ma, Gaoting, Shen, Xiangpeng, Song, Xiangkong, Gao, Yonglei, Guangxian, Nam, Guo, Zaiyu, Zhang, Heliang, Han, Hongxing, Wang, Hao, Liao, Geng, Zhang, Zhenyu, Li, Chaomao, Yang, Zhi, Cai, Chuwei, Huang, Chuming, and Hong, Yifan

Abstract

The benefit of combined treatment with intravenous thrombolysis before endovascular thrombectomy in patients with acute ischaemic stroke caused by large vessel occlusion remains unclear. We hypothesised that the clinical outcomes of patients with stroke with large vessel occlusion treated with direct endovascular thrombectomy within 4·5 h would be non-inferior compared with the outcomes of those treated with standard bridging therapy (intravenous thrombolysis before endovascular thrombectomy).

Published
2022
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15. Purchasing loan participations: the devils in the details

Author

Fawer, Mark S. and Waters, Michael J.

Subjects
Loan sales -- Management, Real estate investment -- Management, Company business management, Banking, finance and accounting industries, Business, Real estate industry
Abstract

Loan participations allow originating lender to leverage its balance sheet better and lay off risk while letting other investors and financial institutions to make an investment at conditions more appropriate to their investment profile. However, junior participants face different risks such as the insolvency of the senior participant. Recommendations on purchasing junior participations are given.

Published
2008

16. Mezzanine loans and the intercreditor agreement: Not etched in stone

Author

Fawer, Mark S. and Waters, Michael J.

Subjects
Financial services industry -- Standards, Mezzanine financing -- Standards, Debtor and creditor, Financial services industry, Banking, finance and accounting industries, Business, Real estate industry
Published
2007

17. Ba2MAsQ5(Q = S and Se) Family of Polar Structures with Large Second Harmonic Generation and Phase Matchability

Author

Iyer, Abishek K., Cho, Jeong Bin, Waters, Michael J., Cho, Jun Sang, Oxley, Benjamin M., Rondinelli, James M., Jang, Joon I., and Kanatzidis, Mercouri G.

Abstract

Noncentrosymmetric chalcogenides containing stereochemically active lone pair elements, such as As, Sb, and Bi, offer a useful way to tune the band gap and enhance the second harmonic generation (SHG) response. Ba2As2–xSbxQ5, Ba2As2–xBixQ5(Q = S and Se), and Ba2As2S4.8Se0.2are new chalcoarsenates that crystallize in the noncentrosymmetric monoclinic space group P21. These five new compounds crystallized with a three-dimensional (3D) Ba2As2Se5-type structure, containing AsQ3units and [As2Q4]2–dimeric units. The [As2Q4]2–dimeric unit can be tuned by replacing As with Sb or Bi and Se with S. In contrast, Ba2As2S5crystallizes in the orthorhombic space group Pca21. Differential thermal analysis suggested that Ba2As2S5, Ba2As2Se5, Ba2AsSbSe5, and Ba2As1.25Bi0.75Se5melt congruently. The [M2Q4]2–unit plays a significant role in tuning the band gap of these compounds, decreasing from 2.02 eV in Ba2As2S5to 1.37 eV in Ba2As1.25Bi0.75Se5. Powder SHG measurements showed all the compounds are essentially phase-matchable at 3300 nm. Ba2AsSbSe5exhibits the highest χ(2)of 36 pm/V and a laser-induced damage threshold of 0.10 GW/cm2, comparable to that of AgGaQ2. These materials show significantly improved SHG behavior response to BaGa4Q7compounds, making them attractive for commercial applications.

Published
2022
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18. First use of gene therapy to treat growth hormone resistant dwarfism in a mouse model

Author

Sia, Kian Chuan, Gan, Shu Uin, Mohd Rodhi, Siti Humairah, Fu, Zhen Ying, Kopchick, John J., Waters, Michael J., and Lee, Kok Onn

Abstract

The only treatment tested for growth hormone receptor (GHR) defective Laron Syndrome (LS) is injections of recombinant insulin-like-growth factor 1 (rhIGF1). The response is suboptimal and associated with progressive obesity. In this study, we treated 4–5-week-old Laron dwarf mice (GHR−/−) with an adeno-associated virus expressing murine GHR (AAV-GHR) injection at a dose of 4 × 1010vector genome per mouse. Serum growth hormone (GH) levels decreased, and GH-responsive IGF1, IGF binding protein 3 (IGFBP3) and acid labile subunit (ALS) increased. There was a significant but limited increase in body weight and length, similar to the response to rhIGF1 treatment in LS patients. All the major organs increased in weight except the brain. Our study is the first to use gene therapy to treat GH-receptor deficiency. We propose that gene therapy with AAV-GHR may eventually be useful for the treatment of human LS.

Published
2022
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19. Structure Tuning, Strong Second Harmonic Generation Response, and High Optical Stability of the Polar Semiconductors Na1–xKxAsQ2

Author

Iyer, Abishek K., Cho, Jeong Bin, Byun, Hye Ryung, Waters, Michael J., Hao, Shiqiang, Oxley, Benjamin M., Gopalan, Venkat, Wolverton, Christopher, Rondinelli, James M., Jang, Joon I., and Kanatzidis, Mercouri G.

Abstract

The mixed cation compounds Na1–xKxAsSe2(x= 0.8, 0.65, 0.5) and Na0.1K0.9AsS2crystallize in the polar noncentrosymmetric space group Cc. The AAsQ2(A= alkali metals, Q= S, Se) family features one-dimensional (1D) 1/∞[AQ2–] chains comprising corner-sharing pyramidal AQ3units in which the packing of these chains is dependent on the alkali metals. The parallel 1/∞[AQ2–] chains interact via short As···Se contacts, which increase in length when the fraction of K atoms is increased. The increase in the As···Se interchain distance increases the band gap from 1.75 eV in γ-NaAsSe2to 2.01 eV in Na0.35K0.65AsSe2, 2.07 eV in Na0.2K0.8AsSe2, and 2.18 eV in Na0.1K0.9AsS2. The Na1–xKxAsSe2(x= 0.8, 0.65) compounds melt congruently at approximately 316 °C. Wavelength-dependent second harmonic generation (SHG) measurements on powder samples of Na1–xKxAsSe2(x= 0.8, 0.65, 0.5) and Na0.1K0.9AsS2suggest that Na0.2K0.8AsSe2and Na0.1K0.9AsS2have the highest SHG response and exhibit significantly higher laser-induced damage thresholds (LIDTs). Theoretical SHG calculations on Na0.5K0.5AsSe2confirm its SHG response with the highest value of d33= 22.5 pm/V (χ333(2)= 45.0 pm/V). The effective nonlinearity for a randomly oriented powder is calculated to be deff= 18.9 pm/V (χeff(2)= 37.8 pm/V), which is consistent with the experimentally obtained value of deff= 16.5 pm/V (χeff(2)= 33.0 pm/V). Three-photon absorption is the dominant mechanism for the optical breakdown of the compounds under intense excitation at 1580 nm, with Na0.2K0.8AsSe2exhibiting the highest stability.

Published
2021
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20. A Reexamination of the Paleoindian Bison Kill at the Alexon Site, Florida

Author

Waters, Michael R., Newell, Zachary A., and Smith, Morgan F.

Abstract

ABSTRACTA chert object embedded in the cranium of a bison found at the Alexon site, Florida, is cited as direct evidence of human and megafauna interaction at the end of the Pleistocene in the American Southeast. Previous analyses identified the chert object as the mid-section of a lanceolate projectile point. Radiocarbon ages on unpurified bison collagen from two separate bison elements yielded Late Pleistocene and Early Holocene ages. We were able to relocate the site and examine the stratigraphy, but our attempts to radiocarbon date the bone failed. We obtained micro-computed tomography scans and used digital imaging software to generate a three-dimensional rendering of the embedded object. Finally, the skull and embedded object were visually examined. We conclude that the object embedded in the skull is not an artifact and that the Alexon site is a paleontological locality.

Published
2021
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21. MAGDALENE.

Author

Waters, Michael

Subjects
MAGDALENE (Poem), WATERS, Michael
Abstract

The poem "MAGDALENE" by Michael Waters is presented. First Line: The wood seems to weep, Last Line: When one of us is gone.

Published
2024

23. In their footsteps

Author

Waters, Michael

Subjects
Manhattan, New York, New York -- Description and travel, Walking tours -- New York, Travel, recreation and leisure
Published
1990

24. Comparison of aspiration-first versus stentriever-first techniques in performing mechanical thrombectomy for large vessel occlusions

Author

Fredrickson, Vance L, Bonney, Phillip A, Rangwala, Shivani D, Catapano, Joshua S, Cole, Tyler S, Cavalcanti, Daniel D, Majmundar, Neil, Wilkinson, D. Andrew, San Roman, Luis, Waters, Michael F, Albuquerque, Felipe C, and Ducruet, Andrew F

Abstract

BackgroundBoth stentriever and direct-aspiration thrombectomy effectively treat large-vessel occlusions. However, data are limited comparing clinical outcomes after aspiration-first versus stentriever-assisted aspiration for thrombectomy.MethodsA retrospective cohort study compared procedure times and radiographic outcomes after two mechanical thrombectomy techniques (aspiration first or stentriever). To minimize bias and variability inherent to multi-operator series, we assessed consecutive patients with cerebrovascular occlusions treated by a single surgeon during a 1 year period at two stroke centers. Expanded Thrombolysis in Cerebral Infarction (eTICI) grades were assessed by an investigator blinded to treatment.ResultsData from 93 patients (median age 70 years) were analyzed: 73 patients (78.5%) were treated with a strentriever-first strategy and 20 (21.5%) were treated with aspiration first, with stentriever rescue therapy required in only three of these cases following unsuccessful aspiration. There were no significant differences in patient demographics, sites of occlusion, or rates of tandem occlusions between aspiration-first and stentriever-assisted groups (p≥0.36). The rate of first-pass eTICI ≥2b was 75.0% (15/20) for aspiration-first and 52.1% (38/73) for strentriever-first groups (p=0.07), while the rate of final eTICI ≥2b was 100% (20/20) and 82.2% (60/72), respectively (p=0.04). The aspiration-first technique was associated with procedural times ≤25 min in a multivariable analysis (adjusted OR 4.77, 95% CI 1.15 to 18.39; p=0.03).ConclusionsIn this single-surgeon series, an aspiration-first technique was associated with a statistically significant improvement in eTICI outcomes and faster procedure times compared with stentriever-assisted aspiration. Further prospective studies are necessary to minimize selection bias inherent in this study design.

Published
2021
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25. One Caw

Author

Waters, Michael

Subjects
Political science
Abstract

Against the snow they're silhouettes, These crows, how many hundreds Burdening branches, these Blunt-scissors-&-construction-paper Kindergarten cut-outs, these Rorschach blots, sloppy calligraphy, Or jagged wounds, the sky torn, But not political, [...]

Published
2018

26. Exploiting Colorimetry for Fidelity in Data Visualization

Author

Waters, Michael J., Walker, Jessica M., Nelson, Christopher T., Joester, Derk, and Rondinelli, James M.

Abstract

Advances in multimodal characterization methods fuel the generation of increasing immense hyper-dimensional data sets. Color mapping is employed for conveying higher dimensional data in two-dimensional (2D) representations for human consumption without relying on multiple projections. How one constructs these color maps, however, critically affects how accurately one perceives data. For simple scalar fields, perceptually uniform color maps and color selection have been shown to improve data readability and interpretation across research fields. Here we review core concepts underlying the design of perceptually uniform color maps and extend the concepts from scalar fields to two-dimensional vector fields and three-component composition fields frequently found in materials-chemistry research to enable high-fidelity visualization. We develop the software tools PAPUC and CMPUC to enable researchers to utilize these colorimetry principles and employ perceptually uniform color spaces for rigorously meaningful color mapping of higher dimensional data representations. Last, we demonstrate how these approaches deliver immediate improvements in data readability and interpretation in microscopies and spectroscopies routinely used in discerning materials structure, chemistry, and properties.

Published
2020
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28. Reconstructing Terminal Pleistocene-Early Holocene Environmental Change at Page-Ladson, Florida Using Diatom Evidence

Author

Perrotti, Angelina G., Winsborough, Barbara, Halligan, Jessi J., and Waters, Michael R.

Abstract

ABSTRACTThe Page-Ladson site, currently buried and submerged in a sinkhole in northwestern Florida, demonstrates evidence of human occupation in North America by 14,550 calendar years ago (cal yr BP). This paper combines new diatom evidence with existing palynological data to strengthen paleoenvironmental interpretations at the site. The Page-Ladson sinkhole was not entirely submerged between ∼15,100 and 14,400 cal yr BP. Conditions at the site became warmer and wetter, and the sinkhole became a turbid pond from ∼14,400 to 12,900 cal yr BP. From ∼12,900 cal yr BP until ∼11,000 cal yr BP, a disappearance of diatoms in the coring location suggests the sinkhole margin was dry. Water levels rose between 11,000 and 9000 cal yr BP, submerging the coring location on the pond margin. These environmental data help contextualize the archaeological data in the region.

Published
2020
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29. Efficacy and safety of nerinetide for the treatment of acute ischaemic stroke (ESCAPE-NA1): a multicentre, double-blind, randomised controlled trial

Author

Hill, Michael D, Goyal, Mayank, Menon, Bijoy K, Nogueira, Raul G, McTaggart, Ryan A, Demchuk, Andrew M, Poppe, Alexandre Y, Buck, Brian H, Field, Thalia S, Dowlatshahi, Dar, van Adel, Brian A, Swartz, Richard H, Shah, Ruchir A, Sauvageau, Eric, Zerna, Charlotte, Ospel, Johanna M, Joshi, Manish, Almekhlafi, Mohammed A, Ryckborst, Karla J, Lowerison, Mark W, Heard, Kathy, Garman, David, Haussen, Diogo, Cutting, Shawna M, Coutts, Shelagh B, Roy, Daniel, Rempel, Jeremy L, Rohr, Axel CR, Iancu, Daniela, Sahlas, Demetrios J, Yu, Amy Y X, Devlin, Thomas G, Hanel, Ricardo A, Puetz, Volker, Silver, Frank L, Campbell, Bruce C V, Chapot, René, Teitelbaum, Jeanne, Mandzia, Jennifer L, Kleinig, Timothy J, Turkel-Parrella, David, Heck, Donald, Kelly, Michael E, Bharatha, Aditya, Bang, Oh Young, Jadhav, Ashutosh, Gupta, Rishi, Frei, Donald F, Tarpley, Jason W, McDougall, Cameron G, Holmin, Staffan, Rha, Joung-Ho, Puri, Ajit S, Camden, Marie-Christine, Thomalla, Götz, Choe, Hana, Phillips, Stephen J, Schindler, Joseph L, Thornton, John, Nagel, Simon, Heo, Ji Hoe, Sohn, Sung-Il, Psychogios, Marios-Nikos, Budzik, Ronald F, Starkman, Sidney, Martin, Coleman O, Burns, Paul A, Murphy, Seán, Lopez, George A, English, Joey, Tymianski, Michael, Demchuk, Andrew, Barber, Philip, Smith, Eric, Bal, Simerpreet, Subramaniam, Suresh, Peters, Steven, Couillard, Phillippe, Klein, Gary, Stys, Peter, Menon, Bijoy, Coutts, Shelagh, Almekhlafi, Mohammed, Hill, Michael, Goyal, Mayank, Wong, John, Mitha, Alim, Eesa, Muneer, Morrish, William, Alqatani, Saad, Kashani, Nima, Joshi, Manish, Zerna, Charlotte, Ospel, Johanna, Venkatesan, Prasanna, Teleg, Erika, Sitaram, Amith, Graham, Brett, Van Gaal, Stephen, Moussaddy, Aimen, Chakraborty, Debabrata, Maraj, Nicholas, Loockey, Andrew, Chen, Shuo, Singh, Ravinder, Alsultan, Abdulaziz, Asuncion, Ria, Tse, Dominic, Doshi, Darshan, Volny, Ondrej, Ojha, Piyush, Wadhwa, Ankur, Marko, Martha, Singh, Nishita, Wasyliw, Sanchea, Ryckborst, Karla, Kenney, Carol, Save, Supriya, Jambula, Anitha, Newcommon, Nancy, Hull, Gavin, Blackstock, Darcy, Kiszczak, Sharon, Zimmel, Leslie, Wright, Michelle, Jahraus, Cari, Andersen, Linda, Bohn, Shelly, Paul, Joseph, Zhang, Oiao, Doram, Craig, Lowerison, Mark, Hanley, Andrea, Campbell, Lori, Ure, Ashley, Taylor, Francis, Hul, Dominic, Wiebe, Samuel, Saluzzi, Marina, Blenkin, Nicole, Frayne, Richard, Buck, Brian, Butcher, Kenneth, Shuaib, Ashfaq, Jeerakathil, Tom, Jickling, Glen, Emery, Derek, Rempel, Jeremy, Owen, Richard, Ashforth, Robert, Yeo, Tom, Kotylak, Trevor, O'Kelly, Cian, Chow, Michael, Siddiqui, Muzaffer, Saqqur, Maher, D'Souza, Atlantic, Lloret, Mar, Butt, Asif, Nomani, Ali, Kalashyan, Hayrapet, Thirunavukkarasu, Sibi, Jabs, Juline, Fairall, Paige, Piquette, Lori, Phillips, Stephen, Green, A. Laine, Gubitz, Gordon, Heidenreich, Jens, Huynh, Thien, Shankar, Jai, Maloney, William, Vandorpe, Robert, Schmidt, Matthias, Pickett, Gwynedd, Weeks, Adrienne, Jarrett, Judith, MacDonald, Debbie, Arsenault, Joanna, Kinnear, Ruth, Mandzia, Jennifer, Mayich, Michael, Boulton, Melfort, Bullrich, Maria, Fridman, Sebastian, Kiwan, Ruba, Lee, Donald, Lownie, Stephen, Khaw, Alexander, Pandey, Sachin, Sharma, Manas, Sposato, Luciano, Wade, Kevin, Beauchamp, Beth, Lambourn, Lindsay, Amato-Marziali, Belinda, Poppe, Alexandre, Roy, Daniel, Daneault, Nicole, Deschaintre, Yan, Gioia, Laura, Jacquin, Grégory, Odier, Céline, Stapf, Christian, Iancu, Daniela, Raymond, Jean, Weill, Alain, Lapierre, Marlène, Jadil, Nadia, Jolteus, Judlène, Teitelbaum, Jeanne, Angle, Mark, Hannouche, Mathew, Badawy, Mohamed, Letourneau, Justin, Cortes, Maria, Linnell, Grant, Tampieri, Donateela, Vieira, Lucy, Moussaddy, Aimen, Legault, Catherine, Durcan, Liam, Moore, Angela, Cole, Erin, Magnussen, Claire, Salmon, Kristiana, Khalil, Salma, Desloges, Isabelle, Waxman, Lindsay, Abdon, Wynne, Lai, Sonia, Dowlatshahi, Dar, Iancu, Daniela, Shamy, Michel, Stotts, Grant, Blacquiere, Dylan, Lesiuk, Howard, Quateen, Aiman, Drake, Brian, Dewar, Brian, Daham, Zeinab, Kelly, Michael, Hunter, Gary, Peeling, Lissa, Graham, Brett, Whelan, Ruth, Garner, Aaron, Urroz, Lilian, Maley, Sharleen, Silver, Frank, Casaubon, Leanne, Pikula, Aleksandra, Del Campo, Martin, Schaafsma, Joanna, Jaigobin, Cheryl, Krings, Timo, Pereira, Vitor, Agid, Ronit, Farb, Richard, Kalman, Libby, Cayley, Anne, Williams, Janice, Stewart, Tim, Misquitta, Karen, Bharatha, Aditya, Selchen, Daniel, Marotta, Thomas, Sarma, Dipanka, Montanera, Walter, Spears, Juluan, Saposnik, Gustavo, Kostyrko, Pawel, Li, Yangmei, Parra-Farina, Carmen, Bengzon Diestro, Jose Danilo, Camden, Marie-Christine, Verreault, Steve, Mackey, Ariane, Audet, Marie-Eve, Milot, Geneviève, Lavoie, Pascale, Gariépy, Jean-Luc, Collard, Karine, Haché, Annette, Van Adel, Brian, Sahlas, Demetrios, Alshanbari, Ahmed, Baldwin, Josephine, Catanese, Luciana, Chen, Bing, De Sa Boasquevisque, Danielle, Deshmukh, Aviraj, Knapman, Jordan, Lamers, Shana, Larrazabal, Ramiro, MacMillan, Susan, Mai, Lauren, Mattia, Alicia, Nayar, Sumiti, Ng, Kuan, Oczkowski, Wieslaw, Perera, Kanjana, Shawawrah, Mays, Shoamanesh, Ashkan, Sobhi, Gita, Syed, Nabeel, Taher, Noran, Vandervelde, Cheyanne, Wang Pharm, Di, Field, Thalia, Van Gaal, Stephen, Teal, Philip, Benavente, Oscar, Wilson, Laura, Mann, Sharanpal, Yip, Samuel, Murphy, Colleen, Heran, Manraj, Rohr, Axel, Settecase, Fabio, Redekop, Gary, Haw, Charles, Maclean, Genoveva, Murray, Karina, Chiu, Rosalin, Flexman, Alana, Strecha, Eilidh, Gayton, Yolanda, Yip, Judy, Swartz, Richard, Boulos, Mark, Gladstone, David, Yu, Amy, Hopyan, Julia, Khosravani, Houman, Manosalva Alzate, Herbert, Southwell, Alisia, Kamra, Maneesha, Lopes, Kaitlyn, Kapoor, Arunima, da Costa, Leodante, Yang, Victor, Dyer, Erin, Shah, Ruchir, Knowles, Brenda, Nichols, Jennifer, Patterson, Jennifer, Cope, Krista, Dickerson, Lee, Barton, Katrina, Gray, Kimberly, Massengale, Ticey, Miller, Melanie, Simpson, Cindy, Walker, Sabrina, Tennyson-Yemm, Chlin, Devlin, Thomas, Frei, Donald, Bellon, Richard, Atchie, Benjamin, Kaminsky, Ian, Wilson, Duandelyn, Schraeder, Nicolle, Arias, Eric, Kodis, Lisa, Talley, Mark, Edinger, Alex, Talley, Tiffany, Dempsey, Ita, Williams, Laurie, Williams, Scott, Kupniewski, Sonny, Fasbinder, Brad, Snead, Joanna, Choe, Hana, Mackenzie, Larami, Weisman, Davi, Kozak, Osman, Shah, Qaisar, Gzesh, Dan, Kulandaivel, Kandan, Khoury, John, Klein, Brad, Bussinger, Patricia, Griffin, Lisa, dePalmo, Ashley, Oliva, Cynthia, Jadhav, Ashutosh, Jovin, Tudor, Kenmuir, Cynthia, Jankowitz, Brian, Gross, Bradley, Rocha, Marcelo, Starr, Matthew, Brown, Merritt, Hawkes, Christine, Shah, Kavit, Tememe, Danoushka, Walker, Gregory, Patel, Pratit, Klein, Bradley, Ziayee, Habibullah, Limaye, Kaustubh, Baxendell, Lisa, Gilchrist, Vicki, Feineigle, Patricia, Toseki Haibach, Kelsea, Van Every, Cathy, Desai, Shashyat, Zulfiqar, Maryam, Gibson, Linda, Barrett, Sean, Turkel-Parrella, David, Arcot, Karthikeyan, DiCrescento, Steven, Farkas, Jeffrey, Filipowski, Gregory, Frontera, Jennifer, Joset, Danielle, Liff, Jeremy, Scher, Erica, McDougall, Cameron, Kelly, Cheryl, Patel, Akshal, Monteith, Stephen, Starkman, Sidney, Atchaneeyasakul, Kunakorn, Burgos, Adrian, Chua, Janice Anne, Gaines, Nathan, Grunberg, Ileana, Guzy, Judy, Liu, Zuolu, Maluste, Neil, Ramirez, Lucas, Sharma, Latisha, Heck, Donald, Brown, Morry, McDonald, Colin, Calderon, Mateo, Hargis, Mitch, Roels, Christina, Emmady, Prabhu, Alvi, Talat, McTaggart, Ryan, Jayaraman, Mahesh, Cutting, Shawna, Smith, Wendy, Foley, Susan, Paolucci, Gino, Has, Richard, Quinn, Katie, Fuller, Lindsey, Brierley, Rebecca, Watkins, Christina, Demir, Nicole, Lopez, George, Vargas, Alejandro, Osteraas, Nicholas, Holtz, Becky, Sauvageau, Eric, Hanel, Ricardo, Aghaebrahim, Amin, Chmayssani, Mohamad, Naval, Neeraj, Day, Jason, Dellorso, Scott, Ludwig, Benjamin, Schemmel, Derek, Ebreo, Nancy, Bell, Karen, Lewis, Lanai, Delucia, Marjorie, Nogueira, Raul, Haussen, Diogo, Frankel, Michael, Bhatt, Nirav, Bianchi, Nicolas, Anderson, Aaron, Belagaje, Samir, Liberato, Bernardo, Rangaraju, Srikant, Al-Bayati, Alhamza, Grossberg, Jonathan, Craft, Leah, Schindler, Kiva, Schaad, Erin, Schultz, Meagan, Southerly, Lorretta, Doppelheuer, Shannon, Charlton, Jacquelyn, Faggard, Jason, Barbret, Zuzana, DukSoo Han, Ethan, Walters, Robin, Dolia, Jaydevsinh, El-Jamal, Sleiman, Eby, Brendan, Saleem, Yasir, Pearl, Harrison, Patel, Kishan, Rahman, Haseeb, Butt, Reema, English, Stephen, Puri, Ajit, Howk, Mary, Singh, Jasmeet, Massari, Francesco, DeMacedo Rodrigues, Katyucia, Kuhn, Anna, English, Joey, Barazangi, Nobl, Telischak, Nick, Kim, Warren, Ross, Josh, DeVole, Nata, Redford, Jessica, Ferreira, Milena, Ponting, Katie, Shen, Helen, Bedenk, Ann, Patel, Susila, Fernandess, Julia, Ke, Michael, Spokoyny, Ilanit, Gao, Billy, Tong, David, Chen, Charlene, Wong, Christine, Choe, Jessica, Martin, Coleman, Summers, Debbie, Boutwell, Christine, Olds, Karin, Crandall, Suzanne, Eatman, John, Akhtar, Naveed, Holloway, William, Halpin, Jared, Donegan, Brett, Schindler, Joseph, Hwang, David, Gilmore, Emily, Petersen, Nils, Sheth, Kevin, Brown, Stacy, Beekman, Rachel, George, Benjamin, Kaddouh, Firas, Falcone, Guido, Wira, Charles, Matouk, Charles, Loomis, Caitlin, Amin, Hardik, Stretz, Hans Christoph, Narula, Reshma, Jasne, Adam, Sansing, Lauren, Agarwal, Tijil, Jasak, Sara, Fontaine, Briana, King, Zachary, Kuohn, Lindsey, Orgass, Hailey, Leary, Megan, Nye, Joan, Halbert, Kelsey, Nystrom, Karin, Neuschatz, Kaile, Petrucci, Dawn, Coppola, Anna, Tarpley, Jason, Joyce, Treasure, Hou, Sam, Umekubo, Mark, Nakamura, Catrice, Ovando, Renee, Zuniga, Diana, Nien, Yih Lin, Basto, Fernando Mayor, Arch, Allison, Jong, Laura, Conrad, William, Abbott, Tara, Yao, Jay, Caganap, Scott, Jordan, John, Teitelbaum, George, Darflinger, Robert, Gupta, Rishi, Bain, Marianne, Budzik, Ronald, Czerniak, Jennifer, Groezinger, Katherine, Hicks II, William, Kaskar, Omran, Katz, Brian, Loochtan, Aaron, Pema, Peter, Rai, Vivek, Vora, Nirav, Brown, Amanda, Goodman, Diane, Danenbergs, Barb, Gossett, Monica, Bang, Oh Young, Chung, Jong-Won, Jeon, Pyoung, Kim, Keon Ha, Lim, Yun Jeong, Heo, Ji Hoe, Nam, Hyo Suk, Kim, Young Dae, Park, HyungJong, Hwang, In Gun, Ha, Wooseok, Choi, Jin Kyo, Jeong, Kyungsun, Rha, Joung-Ho, Park, Hee-Kwon, Yoon, Cindy, Kim, Bo-Kyung, Sohn, Sung-Il, Kim, Chang-hyun, Yoo, Joonsang, Hong, Jeong-Ho, Park, Hyungjong, Kim, Sohyeon, Choi, Moonkyung, Bae, Hyoeun, Lee, Jun Seok, Lee, Jae-Joon, Jun, Go-Eun, Jeon, Sujeong, Campbell, Bruce, Mitchell, Peter, Yassi, Nawaf, Davis, Stephen, Donnan, Geoffrey, Parsons, Mark, Yan, Bernard, Dowling, Richard, Bush, Steven, Wu, Teddy, Shah, Darshan, Zhao, Henry, Salvaris, Patrick, Alemseged, Fana, Ng, Felix, Williams, Cameron, Balabanski, Anna, Dos Santos, Angela, Ng, Jo-Lyn, McDonald, Amy, Jackson, David, Tsoleridis, Jessica, Pesavento, Lauren, Kleinig, Timothy John, Nurs, Roy Drew, Cranefield, Jennifer, Scroop, Rebecca, Cagi, Lavenia, Harvey, Jackson, Waters, Michael, Thornton, John, Brennan, Robert, O'Hare, Alan, Power, Sarah, Williams, David, Boyle, Karl, Moynihan, Barry, Liddy, Ann-Marie, Large, Margaret, Cullen, Ailbhe, Walsh, Roisin, Martin, Emma, Lynch, Julie, McElroy, Sinéad, Murphy, Seán, Coveney, Sarah, Deegan, Caroline, Horgan, Gillian, Kelly, Peter, Laffan, Aoife, Llamas-Osorio, Yudy, Lynch, Catherine, Mac Mahon, Peter, Marnane, Michael, McCabe, John, Burns, Paul, Tauro, Suzanne, Cuddy, Sarah, Rennie, Ian, Smyth, Graham, Flynn, Peter, Wiggam, Ivan, Kerr, Enda, Gordon, Patricia, Fearon, Patricia, Roberts, Geralt, Patterson, Cathy, Adams, Karen, Wells, Brian, McFarland, Margaret, Holmin, Staffan, Moreira, Tiago, Sjöstrand, Christina, Mazya, Michael, Almqvist, Håkan, Wahlgren, Nils, Steinberg, Anna, Cooray, Charith, Eriksson, Einar, Thorén, Magnus, Keselman, Boris, Ahmed, NIaz, Holmberg, Åke, Axelsson, Maria, Berglund, Annika, Thomalla, Götz, Golsari, Amir, Hoppe, Julia, Deb-Chatterji, Milani, Cheng, Bastian, Barrow, Ewgenia, Schlemm, Eckhard, Lettow, Iris, Jensen, Märit, Otto, Dagmar, Jaramillo, Kirsten, Appelbohm, Hannes, Fiehler, Jens, Bester, Maxim, Schönfeld, Michael, Brekenfeld, Caspar, Holst, Brigitte, Wortmann, Ginette, Koch, Friederike, Puetz, Volker, Gerber, Johannes, Abramyuk, Andrij, Kaiser, Daniel, Winzer, Simon, Prakapenia, Alexandra, Pallesen, Lars-Peder, Siepmann, Timo, Barlinn, Kristian, Haase, Kathrin, Sauer, Angela, Psychogios, Marios-Nikos, Liman, Jan, Brehm, Alex, Maus, Volker, Hollstein, Nicole, Reinke, Annika, Neitz, Gustav, Schnieder, Marlena, Schwarz, Margret, Ibrahim, Allam, Müller, Julia, Meister, Stefanie, Bäumle, Berit, Chapot, René, Pilgram-Pastor, Sara, Wallocha, Marta, Stauder, Michael, Celik, Ekin, Stracke, Paul, Müller, Nicole, Weber, Ralph, Velktamp, Roland, Nagel, Simon, Ringleb, Peter Arthur, Heyse, Miriam, Amiri, Hemasse, Mundiyanapurath, Sibu, Chen, Min, Bevrle, Elisabeth, Beck, Perdita, Möhlenbruch, Markus alfred, Tymianski, Michael, Potvin, Alphonse, Harris, Cameron, Wang, Chong, Adams, Corey, Mayor, Diana, Garman, Dave, Chau, Davis, Wu, Jane, Lunn, Janet, Heard, Kathy, Bermanis, Liat, Teyes, Lucy, Constant, Marc, Galsim, Maria, Helbin, Michael, Leroux, Michelle, Felix, Nicole, Bendre, Nilima, Cuthbert, Sandra, Brokx, Steve, Zhang, Yichuan, Lingham, Trudy, Kohli, Yatika, Salter, Michael, Liebeschuetz, Joseph, Hofmann, Frieder, Constant, John, Soeder, Tom, Snoke, Kara, Bologa, Monica, Stahl, Kimberly, and Graziewicz, Maria

Abstract

Nerinetide, an eicosapeptide that interferes with post-synaptic density protein 95, is a neuroprotectant that is effective in preclinical stroke models of ischaemia-reperfusion. In this trial, we assessed the efficacy and safety of nerinetide in human ischaemia-reperfusion that occurs with rapid endovascular thrombectomy in patients who had an acute ischaemic stroke.

Published
2020
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30. GAiN: An integrative tool utilizing generative adversarial neural networks for augmented gene expression analysis

Author

Waters, Michael R., Inkman, Matthew, Jayachandran, Kay, Kowalchuk, Roman M., Robinson, Clifford, Schwarz, Julie K., Swamidass, S. Joshua, Griffith, Obi L., Szymanski, Jeffrey J., and Zhang, Jin

Abstract

Big genomic data and artificial intelligence (AI) are ushering in an era of precision medicine, providing opportunities to study previously under-represented subtypes and rare diseases rather than categorize them as variances. However, clinical researchers face challenges in accessing such novel technologies as well as reliable methods to study small datasets or subcohorts with unique phenotypes. To address this need, we developed an integrative approach, GAiN, to capture patterns of gene expression from small datasets on the basis of an ensemble of generative adversarial networks (GANs) while leveraging big population data. Where conventional biostatistical methods fail, GAiN reliably discovers differentially expressed genes (DEGs) and enriched pathways between two cohorts with limited numbers of samples (n = 10) when benchmarked against a gold standard. GAiN is freely available at GitHub. Thus, GAiN may serve as a crucial tool for gene expression analysis in scenarios with limited samples, as in the context of rare diseases, under-represented populations, or limited investigator resources.

Published
2024
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31. Van der Waals Layered Chiral Structure with Alkali Cation Exchange in LiInP2S6

Author

Qian, Eric K., Nag, Jadupati, Sarker, Saugata, Waters, Michael J., Gopalan, Venkatraman, Rondinelli, James M., and Kanatzidis, Mercouri G.

Abstract

In this study, we report the multiple synthesis routes and characterization of two-dimensional (2D) bimetallic thiophosphate, LiInP2S6, achieved through direct combination and P2S5reactive flux methods. This material features a noncentrosymmetric space group (P312) and exhibits weak van der Waals forces between its layers. Differential thermal analysis indicated a congruent melting point of 785 °C. Structural characterization via single-crystal X-ray diffraction revealed detailed insights into its lattice configuration. Optoelectronic properties were assessed using UV–vis spectroscopy, showing a bandgap of 3.07 eV, and photoemission yield spectroscopy in air (PYSA), which determined a work function of 5.74 eV. Notably, despite the lithium ions being embedded and immobile within the layers rather than being loose in the interlayer space, the material exhibits significant alkali cation exchange capabilities. This happens by dislodging lithium ions from the intralayer space to the interlayer space and then exchanging them with incoming alkali ions. Experiments demonstrated interlayer expansion and significant ion exchange when exposed to Na+, K+, Rb+, and Cs+ions, suggesting potential applications in ion exchange and encapsulation technologies. This work expands the compositional space for 2D layered thiophosphates, highlighting their promise for next-generation electronic devices and heavy metal remediation.

Published
2024
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32. Detrimental Increase of Spin-Phonon Coupling in Molecular Qubits on Substrates

Author

Mullin, Kathleen R., Greer, Rianna B., Waters, Michael J., Amdur, M. Jeremy, Sun, Lei, Freedman, Danna E., and Rondinelli, James M.

Abstract

Molecular qubits are a promising platform for quantum information systems. Although single molecule and ensemble studies have assessed the performance of S= 1/2 molecules, it is understood that to function in devices, regular arrays of addressable qubits supported by a substrate are needed. The substrate imposes mechanical and electronic boundary conditions on the molecule; however, the impact of these effects on spin–lattice relaxation times is not well understood. Here we perform electronic structure calculations to assess the effects of a graphene (Cgr) substrate on the molecular qubit copper phthalocyanine (CuPc). We use a progressive Hessian approach to efficiently calculate and separate the substrate contributions. We also use a simple thermal model to predict the impact of these changes on the spin-phonon coupling from 0 to 200 K. Further analysis of the individual vibrational modes with and without Cgrshows that an overall increase in SPC between the vibrations modes of CuPc with the surface reduces the spin–lattice relaxation time T1. We explain these changes by examining how the substrate lifts symmetries of CuPc in the absorbed configuration. Our work shows that a surface can have a large unintentional impact on SPC and that ways to reduce this coupling need to be found to fully exploit arrays of molecular qubits in device architectures.

Published
2024
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33. Safety and feasibility of the Wahoo Hybrid Access System, a dual-mode guide catheter, in a range of neuroendovascular procedures

Author

Waters, Michael J, Vargas, Jan, Turk, Aquilla, Chaudry, Imran, and Turner, Raymond D

Abstract

Background There is a clinical need for a guide catheter with combined stability and navigability, which can be used in a biaxial system for neuroendovascular procedures in place of triaxial systems.Objective To assess the safety and feasibility of the Q’Apel Medical Wahoo Hybrid Access System, a dual-mode 0.072″ internal diameter guide catheter, in a range of neuroendovascular procedures.Methods We performed a retrospective analysis of consecutive cases from a high-volume tertiary center in which the Wahoo Hybrid Access System was used as the guide catheter. Characteristics of the patients, vascular lesions, procedure, and procedural complications were assessed.Results A total of 102 patients were included for analysis. Vascular lesions were in the anterior circulation in 90 of 102 (88%), and posterior circulation in 12 of 102 (12%). Eighty-four cases were ruptured or unruptured aneurysm embolization procedures, the majority being balloon-assisted coiling (42%) and flow diversion (42%). All cases, including flow diversion, were performed as a biaxial system. There were no instances of prolapse of the catheter beyond the arterial segment in which it was initially placed. The procedure was able to be performed to completion in 101 of 102 (99%) cases. Thromboembolic complications occurred in 5 of 102 (5%); causality in two cases was unrelated to the guide catheter, and three were indeterminate.Conclusions The Wahoo guide catheter is safe and feasible when used in a variety of neuroendovascular procedures. It can accommodate a range of devices, can be safely navigated into distal vasculature, and provides support for a range of procedures, including those which traditionally require triaxial support.

Published
2024
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34. Safety and efficacy of eptifibatide in acute ischemic stroke requiring extracranial carotid artery stenting

Author

Waters, Michael J, Vargas, Jan, Turk, Aquilla, Chaudry, Imran, and Turner, Raymond D

Abstract

Background The antiplatelet management in acute ischemic stroke requiring carotid artery stenting is heterogenous, with no clear guidelines to direct management.Objective To evaluate the safety and efficacy of an intravenous eptifibatide protocol in the management of acute ischemic stroke requiring emergent carotid artery stenting.Methods We performed a retrospective analysis of consecutive patients who underwent carotid artery stenting for acute ischemic stroke at a high-volume tertiary neuroscience center, who were managed with an intravenous eptifibatide protocol. The protocol consists of an intravenous loading eptifibatide bolus (180 mcg/kg) at the time of stenting, followed by a maintenance infusion of 1 mcg/kg/min, then oral or nasogastric loading of dual antiplatelet agents.Results 80 patients were included for analysis. Median presenting NIHSS was 17. Sixty-six patients (83%) had a tandem intracranial occlusion. Six (7.5%) patients developed symptomatic intracranial hemorrhage (sICH). Those who received intravenous thrombolysis were not more likely to develop sICH (10% vs 5%, p = 0.40). Those patients with a presenting ASPECTS <8 were significantly more likely to develop sICH than those with ASPECTS 8–10 (25% vs 3%, p = 0.004).Conclusions Eptifibatide may have a role in the management of acute stroke requiring carotid stenting. Caution may be required in those with established infarct on presentation imaging.

Published
2024
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35. Leprosy in reaction: a medical emergency

Author

Malin, Adam S., Waters, Michael F.R., Shehade, Suhail A., and Roberts, Marguerite M.

Subjects
Skin -- Inflammation, Chronic granulomatous disease -- Case studies -- Diagnosis, Dermatitis -- Diagnosis -- Case studies, Erythema nodosum -- Causes of -- Diagnosis -- Case studies, Leprosy -- Diagnosis -- Case studies, Health, Diagnosis, Case studies, Causes of
Abstract

Leprosy is a chronic granulomatous infectious disease that primarily affects the skin and nerves. The progress of the disease is often considered to be slow and indolent. However, skin or [...]

Published
1991

37. Obeticholic acid for the treatment of non-alcoholic steatohepatitis: interim analysis from a multicentre, randomised, placebo-controlled phase 3 trial

Author

Younossi, Zobair M, Ratziu, Vlad, Loomba, Rohit, Rinella, Mary, Anstee, Quentin M, Goodman, Zachary, Bedossa, Pierre, Geier, Andreas, Beckebaum, Susanne, Newsome, Philip N, Sheridan, David, Sheikh, Muhammad Y, Trotter, James, Knapple, Whitfield, Lawitz, Eric, Abdelmalek, Manal F, Kowdley, Kris V, Montano-Loza, Aldo J, Boursier, Jerome, Mathurin, Philippe, Bugianesi, Elisabetta, Mazzella, Giuseppe, Olveira, Antonio, Cortez-Pinto, Helena, Graupera, Isabel, Orr, David, Gluud, Lise Lotte, Dufour, Jean-Francois, Shapiro, David, Campagna, Jason, Zaru, Luna, MacConell, Leigh, Shringarpure, Reshma, Harrison, Stephen, Sanyal, Arun J, Abdelmalek, Manal, Abrams, Gary, Aguilar, Humberto, Ahmed, Aijaz, Aigner, Elmar, Aithal, Guruprasad, Ala, Aftab, Alazawi, William, Albillos, Agustin, Allison, Michael, Al-Shamma, Sfa, Andrade, Raul, Andreone, Pietro, Angelico, Mario, Ankoma-Sey, Victor, Anstee, Quentin, Anty, Rodolphe, Araya, Victor, Arenas Ruiz, Juan Ignacio, Arkkila, Perttu, Arora, Marty, Asselah, Tarik, Au, Jennifer, Ayonrinde, Oyekoya, Bailey, Robert James, Balakrishnan, Maya, Bambha, Kiran, Bansal, Meena, Barritt, Sidney, Bate, John, Beato, Jorge, Beckebaum, Susanne, Behari, Jaideep, Bellot, Pablo, Ben Ari, Ziv, Bennett, Michael, Berenguer, Marina, Beretta-Piccoli, Benedetta Terziroli, Berg, Thomas, Bonacini, Maurizio, Bonet, Lucia, Borg, Brian, Bourliere, Marc, Boursier, Jerome, Bowman, William, Bradley, David, Brankovic, Marija, Braun, Marius, Bronowicki, Jean-Pierre, Bruno, Savino, Bugianesi, Elisabetta, Cai, Cindy, Calderon, Amy, Calleja Panero, José Luis, Carey, Elizabeth, Carmiel, Michal, Carrión, Jose Antonio, Cave, Matthew, Chagas, Cristina, Chami, Tawfik, Chang, Alan, Coates, Allan, Cobbold, Jeremy, Costentin, Charlote, Corey, Kathleen, Corless, Lynsey, Cortez-Pinto, Helena, Crespo, Javier, Cruz Pereira, Oscar, de Ledinghen, Victor, deLemos, Andrew, Diago, Moises, Dong, Mamie, Dufour, Jean-François, Dugalic, Predrag, Dunn, Winston, Elkhashab, Magby, Epstein, Michael, Escudero-Garcia, Maria Desamparados, Etzion, Ohad, Evans, Larry, Falcone, Robert, Fernandez, Conrado, Ferreira, Jose, Fink, Scott, Finnegan, Kevin, Firpi-Morell, Roberto, Floreani, Annarosa, Fontanges, Thierry, Ford, Ryan, Forrest, Ewan, Fowell, Andrew, Fracanzani, Anna Ludovica, Francque, Sven, Freilich, Bradley, Frias, Juan, Fuchs, Michael, Fuentes, Javier, Galambos, Michael, Gallegos, Juan, Geerts, Anja, Geier, Andreas, George, Jacob, Ghali, Maged, Ghalib, Reem, Gholam, Pierre, Gines, Pere, Gitlin, Norman, Gluud, Lise Lotte, Goeser, Tobias, Goff, John, Gordon, Stuart, Gordon, Frederic, Goria, Odile, Greer, Shaun, Grigorian, Alla, Gronbaek, Henning, Guillaume, Maeva, Gunaratnam, Naresh, Halegoua-De Marzio, Dina, Hameed, Bilal, Hametner, Stephanie, Hamilton, James, Harrison, Stephen, Hartleb, Marek, Hassanein, Tarek, Häussinger, Dieter, Hellstern, Paul, Herring, Robert, Heurich, Eva, Hezode, Christophe, Hinrichsen, Holger, Holland Fischer, Peter, Horsmans, Yves, Huang, Jonathan, Hussaini, Hyder, Jakiche, Antoine, Jeffers, Lennox, Jones, Blake, Jorge, Rosa, Jorquera, Francisco, Joshi, Shoba, Kahraman, Alisan, Kaita, Kelly, Karyotakis, Nicholas, Kayali, Zeid, Kechagias, Stergios, Kepczyk, Thomas, Khalili, Mandana, Khallafi, Hicham, Kluwe, Johannes, Knapple, Whitfield, Kohli, Anita, Korenblat, Kevin, Kowdley, Kris, Krag, Aleksander, Krause, Richard, Kremer, Andreas, Krok, Karen, Krstic, Miodrag, Kugelmas, Marcelo, Kumar, Sonal, Kuwada, Scott, Labarriere, Damien, Lai, Michelle, Laleman, Wim, Lampertico, Pietro, Lawitz, Eric, Lee, Alice, Leroy, Vincent, Lidofsky, Steven, Lim, Tina Huey, Lim, Joseph, Lipkis, Donald, Little, Ester, Lonardo, Amadeo, Long, Michelle, Loomba, Rohit, Luketic, Velimir Anthony Christopher, Lurie, Yoav, Macedo, Guilherme, Magalhaes, Joana, Makara, Mihály, Maliakkal, Benedict, Manns, Michael, Manousou, Pinelopi, Mantry, Parvez, Marchesini, Giulio, Marinho, Carla, Marotta, Paul, Marschall, Hanns-Ulrich, Martinez, Linda, Mathurin, Philippe, Mayo, Marlyn, Mazzella, Giuseppe, McCullen, Mark, McLaughlin, William, Merle, Uta, Merriman, Raphael, Modi, Apurva, Molina, Esther, Montano-Loza, Aldo, Monteverde, Carlos, Morales Cardona, Amilcar, Moreea, Sulleman, Moreno, Christophe, Morisco, Filomena, Mubarak, Abdullah, Muellhaupt, Beat, Mukherjee, Sandeep, Müller, Tobias, Nagorni, Aleksandar, Naik, Jahnavi, Neff, Guy, Nevah, Moises, Newsome, Philip, Nguyen-Khac, Eric, Noureddin, Mazen, Oben, Jude, Olveira, Antonio, Orlent, Hans, Orr, David, Orr, James, Ortiz-Lasanta, Grisell, Ozenne, Violaine, Pandya, Prashant, Paredes, Angelo, Park, James, Patel, Joykumar, Patel, Keyur, Paul, Sonali, Patton, Heather, Peck-Radosavljevic, Markus, Petta, Salvatore, Pianko, Stephen, Piekarska, Anna, Pimstone, Neville, Pisegna, Joseph, Pockros, Paul, Pol, Stanislas, Porayko, Michael, Poulos, John, Pound, David, Pouzar, Joe, Presa Ramos, Jose, Pyrsopoulos, Nikolaos, Rafiq, Nila, Muller, Kate, Ramji, Alnoor, Ratziu, Vlad, Ravinuthala, Ravi, Reddy, Chakradhar, Reddy K G, Gautham, Reddy K R, K. Rajender, Regenstein, Frederic, Reindollar, Robert, Reynolds, Justin, Riera, Andres, Rinella, Mary, Rivera Acosta, Jose, Robaeys, Geert, Roberts, Stuart, Rodriguez-Perez, Federico, Romero, Sandor, Romero-Gomez, Manuel, Rubin, Raymond, Rumi, Mariagrazia, Rushbrook, Simon, Rust, Christian, Ryan, Michael, Safadi, Rifaat, Said, Adnan, Salminen, Kimmo, Samuel, Didier, Santoro, John, Sanyal, Arun, Sarkar, Souvik, Schaeffer, Cynthia, Schattenberg, Jörn, Schiefke, Ingolf, Schiff, Eugene, Schmidt, Wolfgang, Schneider, Jeffrey, Schouten, Jeoffrey, Schultz, Michael, Sebastiani, Giada, Semela, David, Sepe, Thomas, Sheikh, Aasim, Sheikh, Muhammad, Sheridan, David, Sherman, Kenneth, Shibolet, Oren, Shiffman, Mitchell, Siddique, Asma, Sieberhagen, Cyril, Sigal, Samuel, Sikorska, Katarzyna, Simon, Krzysztof, Sinclair, Marie, Skoien, Richard, Solis, Joel, Sood, Siddharth, Souder, Bob, Spivey, James, Stal, Per, Stinton, Laura, Strasser, Simone, Svorcan, Petar, Szabo, Gyongzi, Talal, Andrew, Tam, Edward, Tetri, Brent, Thuluvath, Paul, Tobias, Hillel, Tomasiewicz, Krzysztof, Torres, Dawn, Tran, Albert, Trauner, Michael, Trautwein, Christian, Trotter, James, Tsochatzis, Emanuel, Unitt, Esther, Vargas, Victor, Varkonyi, Istvan, Veitsman, Ella, Vespasiani Gentilucci, Umberto, Victor, David, Vierling, John, Vincent, Catherine, Vincze, Aron, von der Ohe, Manfred, Von Roenn, Natasha, Vuppalanchi, Raj, Waters, Michael, Watt, Kymberly, Wattacheril, Julia, Weltman, Martin, Wieland, Amanda, Wiener, Gregory, Williams A, Alonzo, Williams J, Jeffrey, Wilson, Jason, Yataco, Maria, Yoshida, Eric, Younes, Ziad, Yuan, Liyun, Zivony, Adam, Zogg, Donald, Zoller, Heinz, Zoulim, Fabien, Zuckerman, Eli, and Zuin, Massimo

Abstract

Non-alcoholic steatohepatitis (NASH) is a common type of chronic liver disease that can lead to cirrhosis. Obeticholic acid, a farnesoid X receptor agonist, has been shown to improve the histological features of NASH. Here we report results from a planned interim analysis of an ongoing, phase 3 study of obeticholic acid for NASH.

Published
2019
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38. Extending thrombolysis to 4·5–9 h and wake-up stroke using perfusion imaging: a systematic review and meta-analysis of individual patient data

Author

Campbell, Bruce C V, Ma, Henry, Ringleb, Peter A, Parsons, Mark W, Churilov, Leonid, Bendszus, Martin, Levi, Christopher R, Hsu, Chung, Kleinig, Timothy J, Fatar, Marc, Leys, Didier, Molina, Carlos, Wijeratne, Tissa, Curtze, Sami, Dewey, Helen M, Barber, P Alan, Butcher, Kenneth S, De Silva, Deidre A, Bladin, Christopher F, Yassi, Nawaf, Pfaff, Johannes A R, Sharma, Gagan, Bivard, Andrew, Desmond, Patricia M, Schwab, Stefan, Schellinger, Peter D, Yan, Bernard, Mitchell, Peter J, Serena, Joaquín, Toni, Danilo, Thijs, Vincent, Hacke, Werner, Davis, Stephen M, Donnan, Geoffrey A, Donnan, Geoffrey A., Davis, Stephen M., Ma, Henry, Campbell, Bruce C.V., Churilov, Leonid, Parsons, Mark W., Yan, Bernard, Mitchell, Peter J., Yassi, Nawaf, Sharma, Gagan, Desmond, Patricia M., Oxley, Thomas, Wu, Teddy Y., Shah, Darshan, Zhao, Henry, Rodrigues, Edrich, Salvaris, Patrick, Alemseged, Fana, Ng, Felix, Williams, Cameron, Ng, Jo-Lyn, Tu, Hans T-H., McDonald, Amy, Jackson, David, Tsoleridis, Jessica, McCoy, Rachael, Pesavento, Lauren, Weir, Louise, Bivard, Andrew, Kleinig, Timothy J., Patel, S., Harvey, J., Mahadevan, J., Cheong, E., Balabanski, Anna, Waters, Michael, Drew, Roy, Cranefield, Jennifer, Wijeratne, Tissa, Mackey, Elizabeth, Celestino, Sherisse, Low, Essie, Dewey, Helen M., Bladin, Christopher F., Loh, Poh Sien, Choi, Philip M., Coote, Skye, Frost, Tanya, Hogan, K., Ding, C., McModie, S., Zhang, W.W., Kyndt, Christopher, Moore, A., Ross, Z., Liu, J., Miteff, Ferdinand, Levi, Christopher R., Ang, Timothy, Spratt, Neil, Garcia-Esperon, Carlos, Kaauwai, Lara, Phan, Thanh G., Ly, John, Singhal, Shaloo, Clissold, Benjamin, Wong, Kitty, Krause, Martin, Day, Susan, Sturm, Jonathan, O'Brian, Bill, Grimley, Rohan, Thijs, Vincent, Simpson, Marion, Lee-Archer, Matthew, Brodtmann, Amy, Coulton, Bronwyn, Young, Dennis, Wong, Andrew A., Muller, Claire, Field, Deborah K., Vallat, W., Maxwell, Vanessa, Bailey, Peter, Sabet, Arman, Mishra, Sachin, Tan, Meng, George, K., Barber, P. Alan, Zhao, L., Meretoja, Atte, Curtze, Sami, Tatlisumak, Turgut, Sibolt, G., Tiainen, M., Koivu, M., Aarnio, K., Virta, J., Kasari, O., Eirola, S., Sun, M.C., Chen, T.C., Chuang, C.S., Chen, Y.Y., Lin, C.M., Ho, S.C., Hsiao, P.M., Tsai, C.H., Huang, W.S., Yang, Y.W., Huang, H.Y., Wang, W.C., Liu, C.H., Lu, M.K., Lu, C.H., Kung, W.L., Jiang, S.K., Wu, Y.H., Huang, S.C., Tseng, C.H., Tseng, L.T., Guo, Y.C., Lin, D., Hsu, C.T., Kuan, C.W., Hsu, J.P., Tsai, H.T., Suzuki, M., Sun, Y., Chen, H.F., Lu, C.J., Lin, C.H., Huang, C.C., Chu, H.J., Lee, C.Y., Chang, W.H., Lo, Y.C., Hsu, Y.T., Chen, C.H., Sung, P.S., Ysai, C.L., Jeng, J.S., Tang, S.C., Tsai, L.K., Yeh, S.J., Lee, Y.C., Wang, Y.T., Chung, T.C., Hu, C.J., Chan, L., Chiou, Y.W., Lien, L.M., Yeh, H.L., Yeh, J.H., Chen, W.H., Lau, C.L., Chang, A., Lee, I.Y., Huang, M.Y., Lee, J.T., Peng, G.S., Lim, J.C., Hsu, Y.D., Lin, C.C., Cheng, C.A., Yen, C.H., Yang, F.C., Hsu, C.H., Sung, Y.F., Tsai, C.K., Tsai, C.L., Hsiao, P.M., Lee, A., Hankey, Graeme, Blacker, David, Gerraty, Richard, Chen, C-I., Hsu, C-S., Cowley, Elise, McCoy, Rachael, Sallaberger, Michele, Snow, Barry, Kolbe, John, Stark, Richard, King, John, Macdonnell, Richard, Attia, John, D'Este, Catherine, Bernhardt, Julie, Carey, Leeanne, Cadilhac, Dominique, Anderson, Craig, Howells, David, Barber, A., Connelly, Alan, Macleod, Malcolm, O'Collins, Victoria, Wilson, W., Macaulay, L., Bendszus, Martin, Bluhmki, Erich, Eschenfelder, Christoph, Hacke, Werner, Molina, Carlos, Leys, Didier, Ringleb, Peter, Schellinger, Peter, Schwab, Stefan, Toni, Danilo, Wahlgren, Nils, Wardlaw, Joanna, Oppenheim, Catherine, Lees, Kennedy R., Kaste, Markku, von Kummer, Rüdiger, Chatellier, Gilles, Laage, Rico, Nuñez, Xavier, Ehrenkrona, Christina, Svenson, Ann-Sofie, Cove, Lynda, Niederkorn, Kurt, Gruber, Franz, Kapeller, Peter, Mikulik, Robert, Mas, Jean-Louis, Berrouschot, Jörg, Sobesky, Jan, Köhrmann, Martin, Steiner, Thorsten, Kessler, Christof, Fatar, Marc, Dziewas, Rainer, Poli, Sven, Althaus-Knaurer, Katharina, Bovi, Paolo, Rodriguez, Alain L., Arenillas, Juan F., Muir, Keith, Veltkamp, Roland, Dixit, Anand, Muddegowda, Girish, Kala, Lalit, De Silva, Deidre A., Butcher, Kenneth S., Byrnes, G., Peeters, Andre, Chalk, J.B., Fink, John N., Kimber, Thomas E., Schultz, David, Hand, Peter J., Frayne, Judith, Tress, Brian M., McNeil, John, Burns, R., Johnston, C., and Williams, M.

Abstract

Stroke thrombolysis with alteplase is currently recommended 0–4·5 h after stroke onset. We aimed to determine whether perfusion imaging can identify patients with salvageable brain tissue with symptoms 4·5 h or more from stroke onset or with symptoms on waking who might benefit from thrombolysis.

Published
2019
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40. PHFX/phase 1 sports: athletic training to achieve your best

Author

Waters, Michael

Subjects
Health, Sports and fitness
Abstract

One of the greatest things about the fitness industry is that it's constantly changing. While we all agree that the pioneers before us left a solid road map with a [...]

Published
2014

41. Prayer with Caravaggio.

Author

WATERS, MICHAEL

Subjects
PRAYER with Caravaggio (Poem), WATERS, Michael
Published
2023

42. The Stemmed Point Tradition of Western North America

Author

Waters, Michael R., Goebel, Ted, and Graf, Kelly E.

Abstract

ABSTRACTIn April 2018, the Center for the Study of the First Americans, Hakai Institute, and University of Victoria co-sponsored a five-day workshop investigating the origins of Western Stemmed technologies and their relationship with other Paleoindian and Paleolithic technocomplexes of far western North America, Beringia, and northeast Asia. This Perspective introduces the proceedings of the workshop, which are presented as a series of longer essays in this special issue of PaleoAmerica. The workshop was funded through an endowment created by Robert and Sharon Wilson at Texas A&M University to support the continued multidisciplinary investigation of the peopling of the Americas and dissemination of scientific results to the professional community and the public.

Published
2020
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43. Sphingosine kinase 1 activation by estrogen receptor α36 contributes to tamoxifen resistance in breast cancer

Author

Maczis, Melissa A., Maceyka, Michael, Waters, Michael R., Newton, Jason, Singh, Manjulata, Rigsby, Madisyn F., Turner, Tia H., Alzubi, Mohammad A., Harrell, J. Chuck, Milstien, Sheldon, and Spiegel, Sarah

Abstract

In breast cancer, 17β-estradiol (E2) plays critical roles mainly by binding to its canonical receptor, estrogen receptor (ER) α66, and eliciting genomic effects. E2 also triggers rapid, nongenomic responses. E2 activates sphingosine kinase 1 (SphK1), increasing sphingosine-1-phosphate (S1P) that binds to its receptors, leading to important breast cancer signaling. However, the E2 receptor responsible for SphK1 activation has not yet been identified. Here, we demonstrate in triple-negative breast cancer cells, which lack the canonical ERα66 but express the novel splice variant ERα36, that ERα36 is the receptor responsible for E2-induced activation of SphK1 and formation and secretion of S1P and dihydro-S1P, the ligands for S1PRs. Tamoxifen, the first-line endocrine therapy for breast cancer, is an antagonist of ERα66, but an agonist of ERα36, and, like E2, activates SphK1 and markedly increases secretion of S1P. A major problem with tamoxifen therapy is development of acquired resistance. We found that tamoxifen resistance correlated with increased SphK1 and ERα36 expression in tamoxifen-resistant breast cancer cells, in patient-derived xenografts, and in endocrine-resistant breast cancer patients. Our data also indicate that targeting this ERα36 and SphK1 axis may be a therapeutic option to circumvent endocrine resistance and improve patient outcome.

Published
2018
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44. The Campaign for Women’s Suffrage in York and the 1911 Census Evasion

Author

Waters, Michael

Abstract

AbstractThis article examines the history of women’s suffrage agitation in York one hundred years after some women were able to vote for the first time in Parliamentary elections, in December 1918. It concentrates on the period leading up to the evasion of the census on 2–3 April 1911 and places developments in York in the context of national events. Actions and attitudes of the York Women’s Suffrage Society, which was formed in 1889 and affiliated to the National Union of Women’s Suffrage Societies, are considered, as well as those of the York branch of the more militant Women’s Social and Political Union (WSPU). The WSPU was founded in 1903 and its York branch was not finally established until 1910; its leading figures were the secretary Annie Coultate and its organiser Violet Key Jones. The extent of the 1911 census evasion in York, and the location where evaders spent the night to avoid being counted, are identified for the first time. Four sisters of the Suffield family of Fulford were active suffragettes and were probably among the evaders in York and Scarborough.

Published
2018
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45. Geoarchaeological Investigation at the Buffalo Ranch Site (41BU119), Texas

Author

Hollingshead, Analise and Waters, Michael R.

Abstract

ABSTRACTThe Buffalo Ranch site (41BU119) is located along the Brazos River in Burleson County, Texas, under 10 m of late Quaternary alluvium. Here, Wilson and Big Sandy projectile points were found in natural levee sediments. Three calibrated radiocarbon ages place the site between 9424 and 9666 cal yr BP. Buffalo Ranch adds to our understanding of the late Pleistocene-early Holocene transitional period of this region, providing important information on the ages of these projectile-point forms.

Published
2018
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46. REPORT FROM OCTOBER.

Author

WATERS, MICHAEL

Subjects
REPORT FROM OCTOBER (Poem), WATERS, Michael
Abstract

The poem "REPORT FROM OCTOBER" by MICHAEL WATERS is presented. First Line: Wind loosens the squirrely last leaves. Last Line: That time of year. Horror near, horror far.

Published
2023

47. Pedestrian Mall.

Author

WATERS, MICHAEL

Subjects
*PEDESTRIAN areas
Abstract

The poem "Pedestrian Mall " by Michael Waters is presented. First Line: Loud obscenities reverberated in the dim; Last Line: I was no longer her faithful husband.

Published
2023

48. Parable.

Author

WATERS, MICHAEL

Subjects
PARABLE (Poem), WATERS, Michael
Abstract

The poem "Parable" by Michael Waters is presented. First Line: That Mary Magdalene washed the feet of Christ; Last Line: And, as scholars claim, Jesus' loving wife?

Published
2023

49. Processional

Author

Waters, Michael

Subjects
Literature/writing, Political science
Abstract

One stacks her cells in the spiral staircase of an empty snail-shell writes J. Henri Fabre regarding bees in one rhapsodic essay praising my dear insects for such resourcefulness, but [...]

Published
2005

50. Bosporus

Author

Waters, Michael

Subjects
Literature/writing, Political science
Abstract

for Mihaela Zigzagging eighteen miles north from the Sea of Marmara to the Black Sea, we lean toward Europe on our left, toward Asia failing now, at dusk, on our [...]

Published
2005

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