1. HYCUD: a computational tool for prediction of effective rotational correlation time in flexible proteins.
- Author
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Rezaei-Ghaleh, Nasrollah, Klama, Frederik, Munari, Francesca, and Zweckstetter, Markus
- Subjects
- *
GENETIC databases , *STRUCTURAL bioinformatics , *RIBOSOMAL proteins - Abstract
Motivation: A large fraction of eukaryotic proteins contain unstructured tails or linkers. The presence of flexible regions allows these systems to experience a high level of mobility facilitating their biological function. The complex nature of protein rotation in such flexible modular systems precludes a straightforward application of hydrodynamic methods to calculate their rotational motional properties. We describe the workflow of HYdrodynamic CoUpling of Domains (HYCUD), a program for prediction of effective rotational correlation times in multidomain proteins. The usage of HYCUD is demonstrated by its application to the ribosomal protein L7/L12. Rotational correlation times predicted by HYCUD might be used to detect molecular switch events mediated by disorderorder transitions in interdomain linkers. [ABSTRACT FROM AUTHOR]
- Published
- 2015
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