1. Safety assessment of RhD-positive red cell transfusion in RhD-negative liver-transplant recipients: Single-centre report from India.
- Author
-
Tiwari, Aseem, Arora, Dinesh, Aggarwal, Geet, Dara, Ravi, Bhardwaj, Gunjan, Sharma, Jyoti, Vohra, Vijay, and Soin, Arvinder
- Subjects
- *
RED blood cell transfusion , *TRANSPLANTATION of organs, tissues, etc. , *ERYTHROCYTES , *BLOOD banks , *BLOOD grouping & crossmatching , *DRUG standards - Abstract
Background & objectives: The number of blood components required during a liver-transplant surgery is significant. It is challenging for blood transfusion services to provide the required RhD-negative red blood cells (RBCs) for recipients during the peri-operative period. This retrospective study presents safety data of transfusing RhD-positive RBCs in RhD-negative living donor liver-transplant (LDLT) recipients during the peri-operative period with six-month follow up for risk of developing alloantibodies. Methods: All RhD-negative patients who underwent LDLT and were transfused ABO-compatible but RhD-positive RBC units between January 2012 and May 2018 were included in the study. Twenty one RhD-negative patients who received a total of 167 RhD-positive RBCs peri-operatively were chosen for alloantibody screening. All the patients were started on triple immunosuppression drugs as per the standard hospital protocol. Blood grouping, cross-match and antibody screening were done by column agglutination technique. Results: Post-transplant antibody screen (weekly for 12 wk) was negative, and none of the patients developed anti-D alloantibodies till their last follow up (mean 21 months). Interpretation & conclusions: Our observations suggest that it may be safe to use RhD-positive RBCs peri-operatively in RhD-negative LDLT recipients with low risk of alloimmunization. [ABSTRACT FROM AUTHOR]
- Published
- 2020
- Full Text
- View/download PDF