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Lysine succinylation is a kind of post-translational modification (PTM) that plays a crucial role in regulating the cellular processes. Aberrant succinylation may cause inflammation, cancers, metabolism diseases and nervous system diseases. The experimental methods to detect succinylation sites are time-consuming and costly. This thus calls for computational models with high efficacy, and attention has been given in the literature to develop such models, albeit with only moderate success in the context of different evaluation metrics. One crucial aspect in this context is the biochemical and physicochemical properties of amino acids, which appear to be useful as features for such computational predictors. However, some of the existing computational models did not use the biochemical and physicochemical properties of amino acids. In contrast, some others used them without considering the inter-dependency among the properties. The combinations of biochemical and physicochemical properties derived through our optimization process achieve better results than the results achieved by combining all the properties. We propose three deep learning architectures: CNN+Bi-LSTM (CBL), Bi-LSTM+CNN (BLC) and their combination (CBL_BLC). We find that CBL_BLC outperforms the other two. Ensembling of different models successfully improves the results. Notably, tuning the threshold of the ensemble classifiers further improves the results. Upon comparing our work with other existing works on two datasets, we successfully achieve better sensitivity and specificity by varying the threshold value. [ABSTRACT FROM AUTHOR]

This article presents a study on real-time testing of synchrophasor-based "wide-area monitoring system's applications (WAMS application)." Considering the growing demand of real-time testing of "wide-area monitoring, protection, and control (WAMPAC)" applications, a systematic real-time testing methodology is formulated and delineated in diagrams. The diagrams propose several stages through which an application needs to be assessed (sequentially) for its acceptance prior to implementation into a production system. However, only one stage is demonstrated in this article which comprises the use of a prototyping software toolchain and whose potential is assessed as sufficient for preliminary real-time testing (PRTT) of WAMS applications. The software toolchain is composed of two components: the MATLAB software for application prototyping and other open-source software that allows ingesting prerecorded phasor measurement unit (PMU) signals. With this software toolchain, a PRTT study is presented for two WAMS applications: "testing of the PMU/phasor data concentrator (PDC)" and "testing of wide-area forced oscillation (FO) monitoring application." [ABSTRACT FROM AUTHOR]

All proteomes contain both proteins and polypeptide segments that don't form a defined three-dimensional structure yet are biologically active—called intrinsically disordered proteins and regions (IDPs and IDRs). Most of these IDPs/IDRs lack useful functional annotation limiting our understanding of their importance for organism fitness. Here we characterized IDRs using protein sequence annotations of functional sites and regions available in the UniProt knowledgebase ("UniProt features": active site, ligand-binding pocket, regions mediating protein-protein interactions, etc.). By measuring the statistical enrichment of twenty-five UniProt features in 981 IDRs of 561 human proteins, we identified eight features that are commonly located in IDRs. We then collected the genetic variant data from the general population and patient-based databases and evaluated the prevalence of population and pathogenic variations in IDPs/IDRs. We observed that some IDRs tolerate 2 to 12-times more single amino acid-substituting missense mutations than synonymous changes in the general population. However, we also found that 37% of all germline pathogenic mutations are located in disordered regions of 96 proteins. Based on the observed-to-expected frequency of mutations, we categorized 34 IDRs in 20 proteins (DDX3X, KIT, RB1, etc.) as intolerant to mutation. Finally, using statistical analysis and a machine learning approach, we demonstrate that mutation-intolerant IDRs carry a distinct signature of functional features. Our study presents a novel approach to assign functional importance to IDRs by leveraging the wealth of available genetic data, which will aid in a deeper understating of the role of IDRs in biological processes and disease mechanisms. Author summary: Intrinsically disordered regions (IDRs) in proteins are typically not considered to be functionally as important as the structured parts. However, it is becoming evident that both structured and disordered regions are essential for the repertoire of protein functions. Nevertheless, most of these largely flexible and functionally dynamic protein regions remain uncharacterized. Nevertheless, most of these largely flexible and functionally dynamic protein regions remain uncharacterized. Here, informed by human genetic diversity (i.e., genetic variations from the general population and patients), we identified the IDRs that are more frequently mutated in patients than in relatively healthy individuals, and further show that they carry a set of characteristic functional features. This approach provides a different and effective means to identify unannotated disordered protein segments that are biologically important and lead to pathogenesis upon mutation. [ABSTRACT FROM AUTHOR]

Idiopathic myointimal hyperplasia of the mesenteric veins (IMHMV) is caused by proliferation of smooth muscle cells in the wall of small mesenteric veins and venules with accumulation of a proteoglycan matrix leading to a non-thrombotic, non-inflammatory venous occlusion resulting in venous ischemia. IMHMV is a rare and poorly understood disease, with <20 case reports in the literature. The purpose of this report is to describe the case of a 63-year-old man who presented with this condition that resulted in colonic ischemia necessitating surgical resection. The cause of IMHMV in this patient was attributed to a Chinese herbal supplement used for degenerative osteoarthritis of the knees. A brief review of the literature is provided along with the case report. [ABSTRACT FROM AUTHOR]

This paper proposes a new winding layout for high-power medium-voltage nine-phase induction machines (IMs) based on a single-layer concentrated winding layout having a unity winding factor. The machine is fundamentally an asymmetrical nine-phase IM, where phases are connected in such a way as to provide six terminals that are fed from two three-phase inverters. Compared to a conventional asymmetrical six-phase IM with the same stator and copper volumes, it provides improved torque density, a higher torque/current ratio, and a simpler winding layout. Finite-element simulation is used to compare the proposed winding layout with a conventional split-phase six-phase IM to assess the claimed merits. A 1.5-hp prototype IM is also used for experimental verification. The experimental results are given under both healthy and fault conditions, where the faulty converter is completely disabled. The achievable derating factors under this case are then given and compared with those of conventional six-phase IMs. [ABSTRACT FROM PUBLISHER]

The combined star/pentagon connection of five-phase induction machines was recently demonstrated as a promising compromise between conventional star and pentagon connections. It combines the advantages of both star and pentagon connections without any additional hardware for winding changeover. This connection is based on two five-phase single layer concentrated winding sets shifted in space by π/10 and connected in a combined star/pentagon configuration to provide five-phase terminals. Since the combined star/pentagon connected induction machine is fundamentally an asymmetrical ten-phase machine, the machine mathematical model possesses additional subspaces, which affect the behavior of the machine especially under open line conditions. Starting from the conventional five-phase and m -bar squirrel cage induction machine model, the phase-variable model of the combined star/pentagon connection is introduced in this paper. The corresponding equivalent dq model with five decoupled subspaces, which can account for air gap harmonics up to ninth order, is then derived. Finally, it was shown that the machine model could be simply approximated with only two subspaces similar to a conventional five-phase induction machine with sinusoidally distributed winding, where the flux produced by the nonfundamental subspace could be neglected. The model is verified using a 1 kW prototype five-phase induction machine. [ABSTRACT FROM PUBLISHER]

A study on bubble growth mechanisms and underlying physical phenomena of flow boiling in silicon nanowire (SiNW) microchannels has been performed and compared these results with plainwall microchannels. A new approach in studying bubble dynamics and forces acting on liquid–vapor (L–V) interface of growing bubble has been proposed based on theoretical, experimental and visual studies. Bubble size, liquid film thickness, interfacial properties are measured and L–V interfaces are detected from high speed visualization data and results are analyzed by vision-based approach. Force analysis during instantaneous bubble growth from bubble nucleation to formation of annular flow regime has been performed for both the SiNW and plainwall microchannel configurations. Results from force analysis show the dominance of surface tension at L–V interface of growing bubble which resulted higher heat transfer contact area, lower thermal resistance and higher thin film evaporation. Whereas, inertia force is dominant at L–V interface of fully grown bubble and it helps in bubble removal process and rewetting before flow reversal. Significant differences between SiNW and plainwall microchannels have been observed in bubble growth mechanism, heat transfer mode and forces acting on L–V interface. [ABSTRACT FROM AUTHOR]

In many applications, interior permanent magnet synchronous machines (IPMSMs) with fractional slot concentrated windings (FSCWs) are considered promising candidates in terms of higher power density and efficiency. In addition, employing a multiphase stator winding improves the drive train availability and increases reliability. This study investigates the effect of applying stator shifting to five‐phase FSCW winding IPMSMs to suppress the effect of the slot harmonics by doubling the number of slots. In this case, the winding coil pitch will be two, which stands as a compromise between single‐tooth and distributed winding topologies. This highly improves the air gap flux distribution, significantly reduces both rotor core and magnet eddy current losses, and increases saliency ratio and reluctance torque component. Moreover, an improved performance under fault conditions, in terms of lower torque ripple, and core and magnet losses, adds to the main advantages of this technique. Various slot/pole combinations suitable for five‐phase machines are investigated. A full simulation case study based on two‐dimensional finite element analysis is applied to the 20‐slot/18‐pole stator with single‐tooth winding under both healthy and open‐circuit phase fault cases. [ABSTRACT FROM AUTHOR]

The steady-state modeling of multiphase induction machines (IMs) with m phases under open-line fault conditions is usually carried out based on symmetrical component theory. Hence, the estimation of the machine characteristic curves usually involves complex mathematical calculations and inversion of high-order matrices, which complicates the analysis. Moreover, the effect of the different subspaces’ impedances on the machine performance cannot be easily recognized using this modeling technique. Instead, this paper presents the first attempt to derive a simple equivalent circuit for a five-phase IM under open-line conditions that includes the effect of all subspaces in a single circuit. The derivation is carried out for both star and pentagon connections. The equivalent circuit can be a simple technique to explain the advantages obtained from a pentagon connection compared to the star connection under open-circuit faults. It can also be used to derive a simple expression for torque gain and torque ripple magnitude for different stator connections based on the circuit parameters. The derived equivalent circuits are verified using a 1-kW five-phase prototype machine. [ABSTRACT FROM PUBLISHER]

High-Voltage pulse generators are commonly used in biotechnology, medicine, industrial applications, food processing and drinking water purification. The dc-dc boost converter has been used before in pulsed applications for its ability to amplify a relatively low input dc voltage to a high-voltage output. A high-voltage solid-state chopping switch is then used to chop the generated high output voltage. In this work, a boost-converter based ringing circuit with high voltage gain is proposed for water treatment applications. The basic concept of the proposed approach depends on operating the boost converter under discontinuous current conduction. With the proposed approach, the chopping high-voltage switch at the output stage is eliminated, which positively affects the system cost and efficiency. A full-design of the circuit and passive components is presented to ensure that the desired pulse specifications are achieved. The proposed approach has been validated using simulation and experimental results. [ABSTRACT FROM AUTHOR]

This paper proposes a six-phase surface-mounted permanent-magnet machine with a 24-slot/10-pole fractional slot winding, which not only eliminates the air-gap flux subharmonics, but also minimizes the effect of slot harmonics, which highly affect both the core and magnet losses. The six-phase winding design also offers an improved drive train availability for electric vehicle applications due to its inherent high fault-tolerant capability. When compared with a three-phase design, the proposed winding offers approximately 3.5% improvement in torque density, a significant reduction in both the core and magnet losses, and an improved overall efficiency. The proposed winding is deduced based on the stator shifting concept of two 12-slot/10-pole stators with single tooth windings. The coil span of the resulting machine will be two slots, which stands as a compromise between single tooth and distributed windings. The concept of stator shifting is first presented, and then, a prototype machine is designed and simulated using the 2-D finite-element analysis to validate the proposed concept. A comparative study is also carried out to compare six-phase and three-phase designs with the same slot/pole combination and also with the 18-slot/10-pole combination, which was recently shown to be a competitive alternative. [ABSTRACT FROM AUTHOR]

This paper presents the steady-state mathematical model of a five-phase induction machine with a combined star/pentagon connection. The connection splits the stator winding into two five-phase windings displaced in space by $\pi$/10 and connected in a combined star/pentagon configuration. Recent work limited to an experimental investigation demonstrated that the connection possesses improved fault tolerance when compared to a conventional star-connected stator, as well as avoids the pentagon connection problems. Although the machine has five-phase terminals, it is intrinsically an asymmetrical ten-phase machine, which introduces additional subspaces in the machine's mathematical model. In order to theoretically investigate and thoroughly assess this connection against conventional connections, this paper introduces the steady-state mathematical model based on vector space decomposition and symmetrical component theory. Finite-element analysis is first used to investigate the different harmonic current components induced in the cage rotor circuit, upon which the effect of different subspaces can be clarified and the required transformation matrix from phase variables to their sequence components can be derived. The model is verified using a 1-kW prototype five-phase induction machine. [ABSTRACT FROM PUBLISHER]

The interior permanent magnet (IPM) machine equipped with a fractional-slot concentrated winding (FSCW) has met an increasing interest in electric vehicle applications due to its higher power density and efficiency. Torque production is due to both PM and reluctance torques. However, one of the main challenges of FSCWs is their inability to produce a high-quality magnetomotive force (MMF) distribution, yielding undesirable rotor core and magnet eddy-current losses. Literature shows that the reduction of low-order space harmonics significantly reduces these loss components. Moreover, it has been previously shown that by employing a higher number of layers, although causing some reduction in the winding factor of the torque-producing MMF component, both machine saliency and reluctance torque components are improved. Recently, a dual three-phase winding connected in a star/delta connection has also shown promise to concurrently enhance machine torque of a surface-mounted PM machine while significantly reducing both rotor core and magnet losses. In this paper, a multilayer winding configuration and a dual three-phase winding connection are combined and applied to the well-known 12-slot/10-pole IPM machine with v-shaped magnets. The proposed winding layout is compared with a conventional double-layer winding, a dual three-phase double-layer winding, and a four-layer winding. The comparison is carried out using 2-D finite-element analysis. The comparison shows that the proposed winding layout, while providing similar output torque to a conventional double-layer three-phase winding, offers a significant reduction in core and magnet losses, correspondingly a higher efficiency, improves the machine saliency ratio, and maximizes the reluctance toque component. [ABSTRACT FROM AUTHOR]

One of the main drawbacks of nonoverlapped coils in fractional slot concentrated winding permanent magnet (PM) machines are the high eddy current losses in both rotor core and permanent magnets induced by the asynchronous harmonics of the armature reaction field. It has been shown in the literature that the reduction of low space harmonics can effectively reduce the rotor eddy current losses. This paper shows that employing a combined star-delta winding to a three-phase PM machine with fractional slot windings and with a number of slots equal to 12, or its multiples, yields a complete cancellation to the fundamental magneto-motive force (MMF) component, which significantly reduces the induced rotor eddy current. Besides, it offers a slight increase in machine torque density. A case study on the well-known 12-slot/10-pole PM machine is conducted to explore the proposed approach. With the same concept, the general $n$ -phase PM machine occupying $4n$ slots and with a dual $n$ -phase winding is then proposed. This configuration offers a complete cancelation of all harmonics below the torque producing MMF component. Hence, the induced eddy currents in both rotor core and magnets are significantly reduced. The winding connection and the required number of turns for both winding groups are also given. The concept is applied to a 20-slot/18-pole stator with a dual five-phase winding, where the stator winding is connected as a combined star/pentagon connection. The proposed concept is assessed through a simulation study based on 2-D finite element analysis. [ABSTRACT FROM AUTHOR]

• Bubble dynamics in one single confined microchannel was experimentally investigated. • The effects of hydraulic diameter (D h) of channel, flow rate and heat flux on bubble dynamics are discussed. • The velocity and acceleration of L- V interface were estimated through the analysis of recorded videos using vision-based technique. • The interfacial heat transfer (Nu c) changes with re b during bubble growth and bubble shrinking. • An analysis of energy distributions by bubble dynamics is conducted, heat flux through interface counts over 96% of total input power. Bubble dynamics are fundamental to understand boiling heat transfer mechanism at microscale. In this study, bubble dynamics in one single confined microchannel was experimentally investigated through vision-assisted technique. Experimental studies were performed to understand the effects of hydraulic diameter (D h) of channel, flow rate and heat flux on bubble dynamics, which highly affect the boiling heat transfer performance. First of all, experimental results show that D h has a vital effect on the volume change rate of confined bubble, which can be used to compute the heat flux transported by single bubble. The liquid-vapor (L- V) interfaces were tracked by non-rigid image registration and the velocity and acceleration of L- V interface were estimated through the analysis of recorded videos using vision-based technique. To quantitatively evaluate the impact of bubble dynamics, transient heat transfer rates were presented at different flow rates. Furthermore, the interfacial heat transfer (Nu c) influenced by bubble dynamics was evaluated. Nu c changes with Re b during bubble growth and bubble shrinking. Finally, an analysis of energy distributions by bubble dynamics is conducted. Compared to energy transported by bubble and kinetic energy of bubble, heat flux through interface is significant, dissipating over 96% of total input power. [ABSTRACT FROM AUTHOR]

Wrapping a computation domain with a perfectly matched layer (PML) is one of the most effective methods of imitating/approximating the radiation boundary condition in the Maxwell and wave equation solvers. Many PML implementations often use a smoothly increasing attenuation coefficient to increase the absorption for a given layer thickness, and, at the same time, to reduce the numerical reflection from the interface between the computation domain and the PML. In discontinuous Galerkin time-domain (DGTD) methods, using a PML coefficient that varies within a mesh element requires a different mass matrix to be stored for every element and therefore significantly increases the memory footprint. In this work, this bottleneck is addressed by applying a weight-adjusted approximation to these mass matrices. The resulting DGTD scheme has the same advantages as the scheme that stores individual mass matrices, namely, higher accuracy (due to reduced numerical reflection) and increased meshing flexibility (since the PML does not have to be defined layer by layer), but it requires significantly less memory. [ABSTRACT FROM AUTHOR]

Nine-Switch inverter (NSI) has been recently introduced for independent control of dual ac motors. Although this topology reduces the number of active switches by 25% compared to conventional inverters, it has a main conceptual shortcoming due to voltage gain limitations. In NSI, the voltage gains of both outputs are relatively low, while their maximum achievable magnitudes depend on the phase angle between the two sets. In order to mitigate this problem, this article introduces a new dual output nine-switch boost inverter (NSBI) topology with a minimum number of passive elements. The detailed analysis of NSBI is presented, while the required modifications to conventional pulsewidth modulation (PWM) strategies of the NSI are explained to ensure an acceptable voltage boosting ratio while a high-quality voltage output is obtained. Among different PWM schemes, a modified discontinuous PWM scheme is found optimum with this proposed topology to minimize the voltage stress across switches and improve the input current and output voltage quality. The proposed topology is also validated under both common-frequency and different-frequency modes of operations. Moreover, a clear picture of the NSBI performance compared with other possible counterparts is introduced. The theoretical findings have been corroborated using simulation and experiments. [ABSTRACT FROM AUTHOR]

The nine-phase six-terminal induction machine has recently been proposed as a promising contender to the conventional six-phase asymmetrical winding machine in terms of torque density, phase current quality, stator winding simplicity, and fault-tolerant capability. However, the relatively lower dc-link voltage utilization of a single neutral arrangement in multiphase machines with multiple three-phase windings represents, in general, a technical challenge when compared to windings with isolated star points. Therefore, this paper proposes a new pseudo six-phase winding layout suitable for medium-voltage high-power induction machines, which employs quadruple three-phase stator winding sets, while providing the same terminal behavior of a nine-phase six-terminal winding. Additionally, like the traditional six-phase winding, two possible neutral arrangements can be configured. The proposed winding configuration provides the same dc-link voltage utilization as in conventional dual three-phase winding machines with isolated neutrals. The effect of the circulating zero-sequence current component experienced with a single neutral arrangement can also be avoided. A 1.5 Hp prototype induction machine is used to experimentally validate the proposed six-phase winding layout under both healthy and fault conditions. [ABSTRACT FROM AUTHOR]

In this article, three different types of pulse generators based on multimodule boost converter ringing circuit are presented, namely, interleaved, stacked, and interleaved–stacked with full design and operational concept. The interleaved version is advantageous in generating a burst of pulses with moderate voltage magnitude, where the used modules are fed from a common dc source. On the other hand, the stacked multimodule version can be used to generate high-voltage pulsed output from synchronized modules with a moderate voltage rating. This can be done by feeding the modules from isolated dc sources while connecting their outputs in series. Finally, the interleaved–stacked version can be used for generating a burst of pulses with high-voltage magnitude. The presented pulse generators are valid for resistive loads with exponential decay pulses. The suggested pulse generators are simple and require semiconductor devices with moderate voltage ratings. For given pulse specifications, a detailed design for the passive components of each version is presented in this article. The simulation and experimental results are used to validate the suggested topologies. [ABSTRACT FROM AUTHOR]

In electric drive applications that are based on high‐speed induction motors (IMs) with an extended speed range, stator winding pole‐changing is a possible technique to avoid oversizing the driving motor. The electronic pole changing employed in multiphase IMs has gained recent interest because it avoids physical winding reconfiguration. The effective number of poles of the air gap flux distribution can be electronically altered by simply changing the applied current sequence to a multiphase stator. The main problem associated with this technique is the significant increase in machine magnetising current with the increase in effective pole number when conventional multiphase distributed windings are employed. This study proposes a new fractional‐slot concentrated winding layout with a special stator connection suitable for pole‐amplitude modulated IMs that offers a 2:1 pole ratio while maintaining equal magnetising current for both winding pole pairs. Moreover, constant power operation can be achieved for a speed range of over 4 pu. The main concept is discussed and verified through simulations and experimentally. The machine mathematical model and the required vector space decomposition‐based controller are also presented. [ABSTRACT FROM AUTHOR]

In order to overcome the limitations of the existing classical and solid-state Marx pulse generators, this paper proposes a new modular multilevel voltage-boosting Marx pulse generator (BMPG). The proposed BMPG has hardware features that allow modularity, redundancy, and scalability as well as operational features that alleviate the need of series-connected switches and allows generation of a wide range of pulse waveforms. In the BMPG, a controllable, low-voltage input boost converter supplies, via directing/blocking (D/B) diodes, two arms of a series modular multilevel converter half-bridge sub-modules (HB-SMs). At start up, all the arm's SM capacitors are resonantly charged in parallel from 0 V, simultaneously via directing diodes, to a voltage in excess of the source voltage. After the first pulse delivery, the energy of the SM capacitors decreases due to the generated pulse. Then, for continuous operation without fully discharging the SM capacitors or having a large voltage droop as in the available Marx generators, the SM capacitors are continuously recharged in parallel, to the desired boosted voltage level. Because all SMs are parallelly connected, the boost converter duty ratio is controlled by a single voltage measurement at the output terminals of the boost converter. Due to the proposed SMs structure and the utilization of D/B diodes, each SM capacitor is effectively controlled individually without requiring a voltage sensor across each SM capacitor. Generation of the commonly used pulse waveforms in electroporation applications is possible, while assuring balanced capacitors, hence SM voltages. The proposed BMPG has several topological variations such as utilizing a buck–boost converter at the input stage and replacing the HB-SM with full-bridge SMs. The proposed BMPG topology is assessed by simulation and scaled-down proof-of-concept experimentation to explore its viability for electroporation applications. [ABSTRACT FROM AUTHOR]

In this study, a cost‐effective HVDC shunt tap with low‐number of relatively low‐voltage semiconductor devices and small‐sized passive components is proposed. The proposed architecture is based on employing three single‐phase half‐bridge Modular Multilevel Converters (MMCs), where the DC sides of MMCs are connected in series across the total DC‐link voltage. The MMCs are adopted instead of conventional Two‐Level Voltage Source Converters (2L‐VSCs) to avoid the complications of series connection of Insulated Gate Bipolar Transistors (IGBTs). The involved MMCs in the suggested architecture are operated with the conventional 2L modulation, which results in insignificant arm inductors and Sub‐Modules (SMs) capacitances (in range of µH and µF, respectively). This, in turn, affects positively the converter cost and footprint. Each arm of the involved MMCs can be considered as a high‐voltage valve of a 2L‐VSC. To maintain the balance of SMs capacitors, each arm of the involved (N + 1)‐level MMC has an extra SM (a balancing SM) to select N out of N + 1 SMs during the turn‐off condition. The operational concept, design, and assessment of the proposed architecture are presented in this study. Simulation results are provided for substantiation of the proposed concept. Finally, a scaled down single‐phase prototype is used for experimental validation. [ABSTRACT FROM AUTHOR]

This paper presents a drive system based on a modular multilevel converter (MMC) with high-frequency magnetic channels between adjacent-arm submodules (SMs), suitable for medium-voltage, high-power three-phase variable-speed machines. The configuration employs chains of dual half-bridge (DHB) modules linking adjacent SMs of three-phase symmetrical arms. The DHB modules are operating as power channels enabling energy exchange to restore the power imbalance among the SM capacitors. This allows arms’ ripple-powers to be entirely decoupled through bidirectional power transfer between adjacent-arm SMs, resulting in a near ripple-free SM capacitor voltage profile. Therefore, the MMC common problem of wide voltage fluctuation across SM capacitors is comprehensively solved, independent of the operating frequency. Additionally, a significant reduction in the sizing requirement of SM capacitance is achieved. The configuration is able to drive multimegawatt machines from standstill to the rated speed at the rated torque operating condition. The operating principle of the proposed MMC configuration is explained and necessary mathematical analysis is derived. Features and viability of the proposed drive system are verified through simulation and experimentation. [ABSTRACT FROM AUTHOR]

The application of multiphase machines in high-power applications is now a recognized alternative, thanks to their higher fault-tolerance when compared with standard three-phase systems. Although multiphase machines with multiples of three-phase winding sets have been favored in many applications, literature has shown that machines with a prime number of phases, such as five-phase machines, generally outperform other phase orders, especially in terms of machine torque density. One of the major problems when dealing with a prime number of phases either in academic research or industrial applications is the special stator design. This paper provides a general technique to rewind standard off-the-shelf three-phase stator frames with any general prime phase order while preserving the same copper volume. The proposed winding layout is derived using the star of slots theory and the concept of stator winding shifting. Finite-element simulations are used to investigate examples with different phase orders, while experimental investigation is carried out to corroborate the proposed concept by rewinding a standard three-phase stator as a five-phase machine. [ABSTRACT FROM AUTHOR]

The nine-phase six-terminal induction machine (IM) has been recently proposed as a promising contender to the conventional asymmetrical six-phase type in terms of torque density, stator winding simplicity, and fault-tolerant capability. The stator is composed of nine phases, which are connected in a fashion to only provide six stator terminals. Therefore, this connection combines the high performance of a nine-phase winding with the terminal behavior of a six-phase machine. This paper introduces the machine mathematical model based on the vector space decomposition (VSD) modeling approach. The required current and voltage sequence transformation matrices are derived such that the machine is mathematically regarded as an equivalent six-phase IM with only three decoupled subspaces. This way, the same VSD-based controller structures conventionally applied to six-phase-based systems can be preserved. A 1.5-hp prototype IM is used to experimentally validate the machine model under both healthy and open-phase conditions. [ABSTRACT FROM AUTHOR]

In this paper, a dc–ac buck converter is proposed as a grid-side converter in high voltage dc (HVdc) transmission systems for high-power renewable energy source grid integration. The proposed architecture consists of multimodules of half-bridge voltage source converters (HB-VSCs). The dc terminals of the HB-VSCs are connected in series across the entire dc link (i.e., capacitor tapped), whereas their ac outputs are connected to multiwinding transformers to provide the three-phase terminals for ac grid integration. The proposed grid-connected capacitor-tapped multimodule converter (CT-MC) architecture, inspired from the HVdc shunt tap proposed by ABB, provides a dc–ac conversion with a relatively moderate voltage rating of semiconductor devices. It also provides operation with a lower number of semiconductor devices, gate driver circuits, voltage sensors, and lower total MVA rating of semiconductor devices (67%) compared with the conventional three-phase HB modular multilevel converter, which positively affects the system cost and reduces the computational burden of the employed controller. In this paper, the operational concept and control of the CT-MC are presented along with a capacitor voltage balancing approach. Simulation results are presented during normal and abnormal conditions to show the viability of the proposed architecture. Finally, a scaled down prototype for the CT-MC is employed to validate the converter operation. [ABSTRACT FROM AUTHOR]

This paper presents a dual modular multilevel converter (MMC) topology that utilizes energy exchange between adjacent-arm submodules (SMs), operating with out-of-phase modulation. The proposed configuration is applicable to medium-voltage high-power variable-speed drives incorporating open-end stator winding machines. A novel concept of power decoupling between adjacent-arm SMs in the dual MMC topology is realized through high-frequency transformer-based dc–dc converter modules. This concept offers a significant reduction in the sizing requirement of the SM capacitance and the stored energy in the MMC system, while avoiding the problem of wide voltage fluctuations of SM capacitors, especially at low operating frequencies. The proposed configuration can produce dc voltage; therefore, a machine speed range from zero speed to the rated speed is possible under the rated torque operating condition. The operating principles of the proposed dual MMC configuration are elaborated and necessary mathematical analysis is derived. Simulation and experimental results verify the concept of the proposed drive configuration. [ABSTRACT FROM AUTHOR]

This study proposes an isolated on‐board integrated battery charger using an interior permanent magnet (IPM) machine with a nine‐slot/eight‐pole combination or its multiples, and equipped with a non‐overlapped fractional slot concentrated winding. The proposed winding layout comprises three three‐phase winding sets that are connected in such a way as to provide six motor terminals. Hence, a six‐phase or two three‐phase converters will be required for propulsion. Under motoring mode, the machine can be effectively regarded as a six‐phase machine, which provides a high fault‐tolerant capability, and allows for a 'limp home' mode of operation. Additionally, all magneto motive force subharmonics are eliminated, which significantly reduces the induced rotor eddy current losses, when compared with a conventional three‐phase motor having the same slot/pole combination. In battery charging mode, the winding is reconfigured, so that the machine is considered as a three‐phase to six‐phase rotating transformer. A 40 kW IPM machine is designed and simulated under different modes of operation using two‐dimensional finite element analysis to validate the proposed concept. A small‐scale prototype machine is also used for experimental validation. [ABSTRACT FROM AUTHOR]

High-voltage (HV) pulses are used in electroporation to subject pulsed electric field (PEF) onto a sample under treatment. Pulse-waveform shape, voltage magnitude, pulse duration, and pulse repetition rate are the basic controllable variables required for particular PEF application. In practice, a custom-made pulse generator is dedicated for each PEF application with limited flexibility in changing these variables. In this paper, a universal pulse-waveform generator (UPG) is proposed, where the controller software algorithm can manipulate a basic generated multilevel pulse waveform to emulate many different PEF pulse waveforms. The commonly used PEF HV pulse waveforms can be generated as bipolar or monopolar with controllable pulse durations, repetition times, and voltage magnitudes. The UPG has the ability to generate multilevel pulses that have controllable $dv/dt$, which allows reduction of the electromagnetic interference generated by the converter. The UPG topology is based on half-bridge modular multilevel converter (HB-MMC) cells forming two transition arms in conjunction with two bistate arms, together creating an H-bridge. The HB-MMC cell capacitors provide a controllable energy source which charge from the dc input supply and discharge across the load, while the two bistate arms allow charging the HB-MMC cell capacitors. Hence, the UPG topology offers modularity, redundancy, and scalability. The HB-MMC individual cell capacitance is low and the cell voltages are balanced by employing the sorting and rotating algorithm used in conventional HB-MMC topologies for HV dc transmission applications. The viability of the proposed UPG converter is validated by MATLAB/Simulink simulation and scaled-down experimentation. [ABSTRACT FROM PUBLISHER]

High-voltage (HV) pulse generators (PGs) are the core of pulsed electric field applications. Applying HV pulses produces electrical pores in a biological cell membrane, in which if the size of the pores increases beyond a critical size, the cell will not survive. This paper proposes a new HV-PG based on the modular multilevel converter with full-bridge submodules (FB-SMs). In order to alleviate the need of complicated sensorless or sensor-based voltage balancing techniques for the FB-SM capacitors, a dedicated self-regulating charging circuit is connected across each FB-SM capacitor. The individual capacitor charging voltage level is obtained from three successive stages, namely, convert the low-voltage dc input voltage to a high-frequency square ac voltage, increase the ac voltage level via a nanocrystalline step-up transformer, and rectify the secondary transformer ac voltage via a diode FB rectifier. The HV bipolar pulses are formed across the load in a fourth stage through series connected FB-SMs. The flexibility of inserting and bypassing the FB-SM capacitors allows the proposed topology to generate different pulse-waveform shapes, including rectangular waveforms with specifically reduced dv/dt and ramp pulses. The practical results, from a scaled-down experimental rig with five FB-SMs and a 1-kV peak-to-peak pulse output, validate the proposed topology. [ABSTRACT FROM PUBLISHER]

High-voltage (HV) pulses are used in pulsed electric field (PEF) applications to provide an effective electroporation process, a process in which harmful microorganisms are disinfected when subjected to a PEF. Depending on the PEF application, different HV pulse specifications are required such as the pulse-waveform shape, the voltage magnitude, the pulse duration, and the pulse repetition rate. In this paper, a generic pulse-waveform generator (GPG) is proposed, and the GPG topology is based on half-bridge modular multilevel converter (HB-MMC) cells. The GPG topology is formed of four identical arms of series-connected HB-MMC cells forming an H-bridge. Unlike the conventional HB-MMC-based converters in HVdc transmission, the GPG load power flow is not continuous which leads to smaller size cell capacitors utilization; hence, smaller footprint of the GPG is achieved. The GPG topology flexibility allows the controller software to generate a basic multilevel waveform which can be manipulated to generate the commonly used PEF pulse waveforms. Therefore, the proposed topology offers modularity, redundancy, and scalability. The viability of the proposed GPG converter is validated by MATLAB/Simulink simulation and experimentation. [ABSTRACT FROM PUBLISHER]

This paper presents a new high-voltage pulse generator, which is based on positive and negative buck-boost (BB) converters fed from a relatively low voltage dc supply. The proposed generator is able to generate unipolar or bipolar high-voltage pulses via operating the BB converters with series or parallel connected outputs respectively using a common input dc source. The components of each converter are rated at half of the pulsed voltage magnitude in the unipolar mode. The converters in the proposed pulse generator operate in discontinuous conduction mode. This enhances system efficiency, as the circuit only operates when it is desired to generate a pulsed output voltage, otherwise the circuit is switched to idle mode with zero current. Detailed illustration of the proposed approach is presented along with a full design of the system components for given output pulse specifications. Finally, simulation and experimental results are presented to validate the proposed concept. [ABSTRACT FROM PUBLISHER]

Bipolar repetitive high-voltage pulse generators are commonly used in modern pulsed power applications. Conventionally, bipolar high-voltage pulses can be generated by adding a high-voltage H-bridge at the output stage of a unipolar high-voltage pulse generator which increases complexity and cost of the bipolar high-voltage pulse generator. In this paper, a boost-inverter-based bipolar high-voltage pulse generator with high-voltage gain is proposed. The proposed generator can provide high-voltage bipolar output pulses with the desired specifications from a low input dc voltage. The proposed generator is based on employing two bidirectional boost dc–dc converters, where the load is connected differentially between the boost converters’ output terminals. In the proposed approach, four controlled switches are required. Only two out of these four switches are rated at the high-voltage output level which affects positively the system cost. A detailed illustration of the proposed approach along with the design of its passive components is presented in this study. Simulation and experimental results are used to validate the proposed approach. [ABSTRACT FROM AUTHOR]

The half‐bridge modular multilevel converter (HB‐MMC) is one of the most promising topologies for high‐voltage direct current (HVDC) systems. Unlike full‐bridge MMC (FB‐MMC) and clamp double sub‐module MMC (CDSM‐MMC), HB‐MMCs are defenceless against DC side faults. Different types of DC circuit breakers (DC CBs) assisted with arrester banks/damping resistors such as solid‐state CB and hybrid DC CBs can be used to interrupt the DC fault current. Arrester banks are used to protect against overvoltage after interrupting the fault current and in turn to demagnetise the circuit inductors. The main disadvantage of the arresters is that they forcibly break apart when they are overloaded. In this study, an arrester‐less fault current limiter is proposed for HB‐MMC configuration, which provides an opposing voltage during the DC side fault. This is achieved by inserting external pre‐charged capacitors in the DC current path during the fault. The selection of these external capacitors, their suitable initial voltages, and their charging stations are also presented in this study. A comparison between the proposed scheme and the CDSM‐MMC has been held as well. The proposed protection scheme is assessed using a simulation study for a point‐to‐point nine‐level HB‐MMC‐based HVDC system. [ABSTRACT FROM AUTHOR]

Repetitive Pulsed Electric Field (PEF) is a common technique for disinfecting liquids. By applying adequate PEF across germ cell membranes, an irreversible electroporation process, and cell destruction can be achieved. The PEF can be generated by applying a repetitive pulsed voltage using a high-voltage pulse generator across the cell membrane. Unipolar and bipolar high-voltage pulse generators are commonly used. Bipolar pulse generators can be implemented by employing a unipolar generator with an H-bridge output stage. The main disadvantage of this method is that the switches of the H-bridge are rated at the output high-voltage level, i.e. series-stacked semiconductor devices should be employed with static and dynamic voltage sharing to implement high-voltage switches. In this paper, a half-bridge submodule-based bipolar modular high-voltage pulse-generator fed from a relatively low-voltage dc supply is proposed. In the proposed approach, relatively low-voltage Insulated Gate Bipolar Transistors (IGBTs) are required to generate the high-voltage bipolar pulses. A detailed illustration of the proposed concept is presented. Simulation results are used to assure the viability of the proposed concept. Finally, experimental results have been obtained from a low-voltage model of the proposed generator. [ABSTRACT FROM AUTHOR]

The role of irreversible electroporation using pulsed electric field is to generate high-voltage (HV) pulses with a predefined magnitude and duration. These HV pulses are applied to the treatment chamber until decontamination of the sample is completed. In this paper, a new topology for HV rectangular pulse generation for water disinfection applications is introduced. The proposed topology has four arms comprised of series-connected half bridge modular multilevel converter cells. The rectangular pulse characteristics can be controlled via the software controller without any physical changes in power topology. The converter is capable of generating both bipolar and monopolar HV pulses with microsecond pulse durations at high a frequency rate with different characteristics. Hence, the proposed topology provides flexibility by software control, along with hardware modularity, scalability, and redundancy. Moreover, a cell’s capacitance is relatively small, which drastically reduces the converter footprint. The adopted charging and discharging process of the cell capacitors in this topology eliminate the need of any voltage measurements or complex control for cell-capacitors voltage balance. Consequently, continuity of converter operation is assured under cell malfunction. In this paper, analysis and cell-capacitor sizing of the proposed topology are detailed. Converter operation is verified using MATLAB/Simulink simulation and scaled experimentation. [ABSTRACT FROM AUTHOR]

Adjustable-speed drives based on multiphase motors are of significant interest for safety-critical applications that necessitate wide fault-tolerant capabilities and high system reliability. Although multiphase machines are based on the same conceptual theory as three-phase machines, most undergraduate electrical machines and electric drives courses do not cover this topic. Setting aside the analysis challenges addressed in state-of-the-art literature, undergraduate electrical machines and power electronics courses are a good opportunity for students to understand the main concepts underlying such electric drive systems. This paper presents an adjustable-speed multiphase drive system senior project for electrical engineering undergraduate students that addresses their attainment of the course's learning outcomes. Eight of the course's students were assigned to build the multiphase variable-speed motor drive system. From a pedagogical point of view, this paper describes the methodology of using a senior project to engage students through experiential learning of electric drive systems, which span disciplines such as electrical machines, control, power electronics, and electronics. Students acquire both technical skills and soft skills, which are evaluated through various assessment activities. A number of lessons for future work have been drawn from the experience of applying this project-based learning approach. [ABSTRACT FROM AUTHOR]

In order to generate bipolar high-voltage (HV) pulses across certain load from HV dc (HVdc) power supply, a voltage source inverter (VSI) stage should be inserted between the load and the supply. In order to meet the required HV level, series connection of semiconductor devices should be employed with dynamic voltage sharing between the involved devices. Modular multilevel converter (MMC) can be used instead of the conventional two-level VSI to alleviate the complexity introduced by the deployment of series-connected devices. The voltage level of the HVdc power supply and the voltage rating of the available semiconductor devices determine the suitable number of MMC voltage levels ( $N$ ). Capacitor voltage balancing is a vital issue for proper operation of the MMC. In general, conventional sensor-based balancing techniques require a significant amount of measurements, which increases the complexity of the system. In addition, the high dv/dt during switching times causes electromagnetic interference, which may adversely affect the accuracy of the measurements. In this paper, a sensorless voltage balancing technique is proposed for the MMC-based bipolar HV pulse generator that reduces the system sensitivity, cost, and complexity. A detailed illustration of the proposed approach is presented in this paper. The simulation and experimental results are used to validate the proposed concept. [ABSTRACT FROM AUTHOR]

Modular multilevel converters (MMCs) have become one of the most promising topologies for high-voltage dc–ac conversion. DC-side fault blocking capability of the MMC has prompted significant research in recent years. In this paper, a new switched capacitor submodule (SCSM) for MMCs is proposed which provides operation with DC fault blocking capability. In addition, successful voltage balancing is achieved with half the number of voltage sensors used with existing MMC cells. Generally, conventional sensor-based balancing techniques require a significant amount of measurements, 2m(N-1) voltage sensors, and 2m current sensors for an N-level m-phase MMC. The proposed cell will thus aid in reducing the complexity of the control system. A detailed illustration of the operational concept of the proposed architecture is presented in this paper. A comparison between the proposed SCSM and other existing MMC cells has been included to highlight the benefits of the proposed SCSM. A simulation model for an MMC-based HVDC system along with the proposed cell has been built to test its performance during normal as well as abnormal operating conditions. The simulation results show the effectiveness of the proposed architecture. [ABSTRACT FROM PUBLISHER]

One of the main merits offered by multiphase machines is their high fault-tolerant capability. Literature has demonstrated that the performance of multiphase induction machines under fault conditions is affected by the employed stator winding connection. In open-loop controlled five-phase machines, the star connection is favorable under healthy conditions while the pentagon connection is favorable and yields a lower derating factor under the open phase condition. In this paper, a new combined star/pentagon single layer winding layout that combines the advantages of both star and pentagon connections is proposed for a five-phase induction machine. Although the proposed winding is intrinsically an asymmetrical ten-phase machine, the proposed connection allows for only five-phase terminals. Moreover, the proposed winding not only yields better flux distribution compared to a conventional single layer winding, but also provides a complete cancellation of the third-order harmonic flux component caused by the induced third sequence currents due to the saturation effect and/or under unbalanced operation. Hence, the machine losses are decreased, which improves the overall machine efficiency. For the healthy case, the machine is similar to a conventional star connected five-phase machine. However, with one phase open, the proposed connection results in a lower derating factor compared to conventional connections for both open-loop and optimal current control techniques. A 1-kW prototype machine is used for experimental verification. [ABSTRACT FROM AUTHOR]

Conventional dual-active bridge topologies provide galvanic isolation and soft-switching over a reasonable operating range without dedicated resonant circuits. However, scaling the two-level dual-active bridge to higher dc voltage levels is impeded by several challenges among which the high dv/dt stress on the coupling transformer insulation. Gating and thermal characteristics of series switch arrays add to the limitations. To avoid the use of standard bulky modular multilevel bridges, this paper analyzes an alternative modulation technique, where staircase approximated trapezoidal voltage waveforms are produced; thus, alleviating developed dv/dt stresses. Modular design is realized by the utilization of half-bridge chopper cells. This way the analyzed dc-dc transformer employs modular multilevel converters operated in a new mode with minimal common-mode arm currents, as well as reduced capacitor size, hence reduced cell footprint. Suitable switching patterns are developed and various design and operation aspects are studied. Soft-switching characteristics will be shown to be comparable to those of the two-level dual-active bridge. Experimental results from a scaled test rig validate the presented concept. [ABSTRACT FROM AUTHOR]

Despite the increased interest in multiphase induction machines for safety-critical applications, machine parameter identification for the different sequence planes is still a challenging research point. In most available literature, the effect of nonfundamental sequence planes is overlooked due to the assumption of sinusoidal winding distribution and healthy operation. However, in a single layer or concentric winding layout with an odd number of phases, the effect of flux produced by nonfundamental sequence planes cannot be ignored for the open-phase case. This paper proposes a simple offline method to estimate the parameters of a five-phase induction machine corresponding to different sequence planes. The proposed technique can estimate the stator leakage inductance as well as the magnetizing inductance of both fundamental and third sequences by applying a quasi-square voltage to the stator winding while the machine is running at no-load. Consequently, the rotor circuit parameters of the fundamental sequence plane can be simply obtained by deducting the stator impedance from the blocked rotor machine impedance. For the third sequence plane, an approximate relation to estimate these parameters based on the measured fundamental sequence rotor parameters is also given. An experimental 1.5 Hp prototype machine is used to verify the proposed technique. [ABSTRACT FROM PUBLISHER]

The traditional neutral point clamped (NPC) inverter has short-circuit problem. The risk of short-circuit can be decreased by using dead-time in the switching signals. However, the dead-time decreases the achievable output voltage and causes distortion in the waveforms. To overcome the short-circuit problem, dual-buck NPC (DB-NPC) and split-inductor NPC (SI-NPC) inverters have been researched. However, the voltage stress of the two external diodes in the DB-NPC inverter is higher. On the other hand, the SI-NPC inverter has a problem of generating huge voltage spikes in the dead-time, which can destroy the semiconductor devices. In addition, the SI-NPC inverter cannot provide reactive power. This article presents a family of NPC inverters consisting of single-phase, three-phase, and cascaded inverters. The proposed inverters have no short-circuit and dead-time issues, therefore no high voltage and current spikes are caused. Also, the dead-time in the switching signals can be minimized. As a result, the magnitude of the output waveforms can be increased, and quality can be improved. Unlike the DB-NPC inverter, the voltage stress of all the semiconductor in the proposed inverter is lower, and unlike the SI-NPC inverter the proposed inverter provides reactive power. In this article, the proposed three-level NPC inverter is analyzed, designed, and tested. The voltage stress of the semiconductor devices in the proposed inverter is half of the source voltage, whereas in the conventional DB-NPC inverter the voltage stress of the two external diodes is the source voltage. In addition to the aforementioned benefits, the proposed cascaded inverter reduces the total number of inductors. To verify the analysis, detailed simulation, and experimental results of the proposed three-level inverter with input voltage 640 V, output power 1.2 kW, and output voltage 220 Vrms are provided. [ABSTRACT FROM AUTHOR]

The modular multilevel converter (MMC) is a promising candidate for high-/medium-voltage high-power applications such as medium voltage ac drives due to its modularity, reliability, and scalability. The main challenge of a conventional MMC is low-frequency operation. Capacitor voltage ripple is inversely proportional to the operating frequency. Hence, operating at low frequency necessitates employing large submodule capacitances to limit voltage ripple or the utilization of energy equalization modules (EEMs). The first option negatively affects converter lifetime, and the second option requires a large number of semiconductor devices and isolating transformers. In this article, a modified MMC topology with self-energy equalization is proposed to ensure converter operation with balanced capacitor voltages with low ripple during zero-/low-frequency conditions. Operating with balanced capacitor voltages with low ripple is achieved by maintaining the same energy level in the involved upper and lower arms. A low device count alternative to the EEMs approach is proposed in this work. Detailed illustration of the operational concept and design of the associated passive components is presented. The performance of the proposed medium voltage ac drive is elucidated through simulation and experimental results. [ABSTRACT FROM AUTHOR]

This article presents the operation of onboard integrated battery chargers tied to a nine-phase EV-drive train, shedding light on the charging performance during the postfault operation, when one or more faulty inverter legs are disconnected. The objective in that case is to ensure balanced grid currents, while maintaining minimum machine losses at zero average torque production. The proposed concept requires a minimalistic change from a control structure perspective to switch between the pre- and postfault cases. Limitations and fault cases are discussed and corroborated with experimental tests on a 1.5-kW prototype.The derived concept is parameter independent and applicable to nine-phase drives, irrespective of the type of rotor used. [ABSTRACT FROM AUTHOR]

Interpretation of the colossal number of genetic variants identified from sequencing applications is one of the major bottlenecks in clinical genetics, with the inference of the effect of amino acidsubstituting missense variations on protein structure and function being especially challenging. Here we characterize the threedimensional (3D) amino acid positions affected in pathogenic and population variants from 1,330 disease-associated genes using over 14,000 experimentally solved human protein structures. By measuring the statistical burden of variations (i.e., point mutations) from all genes on 40 3D protein features, accounting for the structural, chemical, and functional context of the variations' positions, we identify features that are generally associated with pathogenic and population missense variants. We then perform the same amino acid-level analysis individually for 24 protein functional classes, which reveals unique characteristics of the positions of the altered amino acids: We observe up to 46% divergence of the class-specific features from the general characteristics obtained by the analysis on all genes, which is consistent with the structural diversity of essential regions across different protein classes. We demonstrate that the function-specific 3D features of the variants match the readouts of mutagenesis experiments for BRCA1 and PTEN, and positively correlate with an independent set of clinically interpreted pathogenic and benign missense variants. Finally, we make our results available through a web server to foster accessibility and downstream research. Our findings represent a crucial step toward translational genetics, from highlighting the impact of mutations on protein structure to rationalizing the variants' pathogenicity in terms of the perturbed molecular mechanisms. [ABSTRACT FROM AUTHOR]

Aim: The aim of this study was to investigate the effectiveness of using recombinant human follicle-stimulating hormone (FSH) compared with pituitary-derived porcine FSH given as one dose or multiple doses on the neonatal traits, follicular dynamics, and maternal blood biochemical constituents in Noemi ewes. Materials and Methods: A 3×2 factorial arrangement was designed utilizing 60 adults Noemi ewes to test the effects of using two sources of FSH (human vs. porcine) in addition to control, either given as a single total dose or six descending doses to provoke twinning. Six treatments (T) were tested (n=10 ewes/T). C1 and C6 served as control ewes given saline as one dose and six doses, respectively; H1 and H6 ewes were given human FSH as one and six doses; and P1 and P6 ewes were given porcine FSH similar to the above treatments. Saline and/or FSH administration were administered at days 8, 9, and 10 of the 10-day controlled internal drug release (CIDR) implant. At CIDR removal, fertile rams were used for natural mating. Blood samples for the assessment of serum metabolites were collected. Results: Twinning increased in FSH-treated ewes than control. However, giving FSH of either source as a single dose resulted in a higher incidence of stillbirths. Pregnancy rates were 30, 40, 50, 60, 70, and 80% in C1, C6, P1, P6, H1, and H6, respectively. Respective percent of ewes delivering twins/multiple birth was 0, 0, 80, 66.7, 71.4, and 87.5%. FSH of human source was more efficient for folliculogenesis than porcine FSH. Administration of FSH increased blood cholesterol, decreased high-density lipoprotein; however, low-density lipoprotein levels were not different than control. Moreover, an interaction (p<0.05) exists between source and type of FSH administration on blood glucose. Six doses of FSH elevated blood protein. Blood albumin decreased by porcine-FSH but not affected by human-FSH. Blood globulins were not different due to source of FSH, whereas giving FSH as six doses increased globulins than in single-dose protocol. Contrariwise, an interaction was found between source and type of FSH administration on elevating the activity of alanine aminotransferase and reducing the activity of aspartate aminotransferase. Conclusion: Administration of human FSH at 180 IU in six descending doses resulted in the best neonatal outcomes and maternal health in Noemi ewes. [ABSTRACT FROM AUTHOR]

Conventional modular multilevel converters (MMCs) are promising converters for high-voltage high-power applications. Unlike DC-AC conversion, DC-DC conversion of MMCs suffers from unbalanced capacitor voltages due to the energy drift problem. In this study, a new modular DC-DC converter is proposed, which consists of front-end half-bridge MMC with half-bridge submodules followed by full-bridge MMC with full-bridge submodules. The proposed modular multilevel DC-DC converter can be used effectively for connecting two different DC voltage levels in high-/medium-voltage DC grids. The proposed architecture provides successful DC-DC conversion with balanced capacitor voltages throughout the arm interchange concept. It also provides a high conversion ratio, bidirectional power flow, low losses, low current stresses, reduced number of submodules, and DC fault blocking capability. Detailed illustration, operational concept, and design of the proposed architecture with the arm interchange concept are presented. Simulation results for a high-voltage high-power DC-DC converter with the suggested approach are presented to demonstrate the system performance during different normal as well as abnormal operating conditions. Finally, a scaled-down prototype has been implemented for validation. The extracted simulation and experimental results elucidate the presented claims. [ABSTRACT FROM AUTHOR]

Conventional modular multilevel converters (MMCs) are promising converters for high‐voltage high‐power applications. Unlike DC–AC conversion, DC–DC conversion of MMCs suffers from unbalanced capacitor voltages due to the energy drift problem. In this study, a new modular DC–DC converter is proposed, which consists of front‐end half‐bridge MMC with half‐bridge submodules followed by full‐bridge MMC with full‐bridge submodules. The proposed modular multilevel DC–DC converter can be used effectively for connecting two different DC voltage levels in high‐/medium‐voltage DC grids. The proposed architecture provides successful DC–DC conversion with balanced capacitor voltages throughout the arm interchange concept. It also provides a high conversion ratio, bidirectional power flow, low losses, low current stresses, reduced number of submodules, and DC fault blocking capability. Detailed illustration, operational concept, and design of the proposed architecture with the arm interchange concept are presented. Simulation results for a high‐voltage high‐power DC–DC converter with the suggested approach are presented to demonstrate the system performance during different normal as well as abnormal operating conditions. Finally, a scaled‐down prototype has been implemented for validation. The extracted simulation and experimental results elucidate the presented claims. [ABSTRACT FROM AUTHOR]

The nine-arm modular multilevel converter (9A-MMC) has been recently proposed as a reduced MMC topology variation for six-phase drive applications, with 25% reduction in the number of employed arms and associated components, compared to a standard dual three-phase MMC, however with a limited output voltage amplitude. This paper proposes a hybrid 9A-MMC comprised of half-bridge submodules (SMs) in both the upper and lower arms, and full-bridge SMs in the middle arms. By employing the negative-voltage state of the full-bridge SMs, the hybrid 9A-MMC avoids the limitations imposed on the dc-link voltage utilization, while achieving further reduction in the component count, compared to a standard 9A-MMC with identical half-bridge SMs. The operating principles of the proposed hybrid 9A-MMC are illustrated with mathematical analysis, whereas its characteristics are verified through both simulation and experimentation. An assessment of the proposed topology quantifying its employed components is also provided, in comparison to other MMC-based six-phase machine drives. [ABSTRACT FROM AUTHOR]