1. Enhanced mitochondrial function in B cells from elderly type-2 diabetes mellitus patients supports intrinsic inflammation.
- Author
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Frasca, Daniela and Bueno, Valquiria
- Subjects
MITOCHONDRIAL physiology ,IN vitro studies ,FLOW cytometry ,PEARSON correlation (Statistics) ,RESEARCH funding ,BODY mass index ,ACADEMIC medical centers ,T-test (Statistics) ,INFLUENZA vaccines ,VACCINE effectiveness ,POLYMERASE chain reaction ,ENZYME-linked immunosorbent assay ,AGE distribution ,DESCRIPTIVE statistics ,HEMAGGLUTINATION tests ,METABOLITES ,MESSENGER RNA ,TYPE 2 diabetes ,AMYLOID ,STATISTICS ,INFLAMMATION ,CYTOKINES ,FACTOR analysis ,DATA analysis software ,B cells ,OBESITY ,C-reactive protein ,TUMOR necrosis factors ,INTERLEUKINS ,BIOMARKERS - Abstract
In this paper, we measured B cell function in elderly healthy individuals (E
H ) and in elderly patients with Type-2 Diabetes Mellitus (T2DM, ET2DM ), which are treatment-naive, as compared to healthy young (YH ) individuals. Results show a higher serum inflammatory status of elderly versus young individuals, and especially of ET2DM versus EH . This status is associated with a reduced response to the seasonal influenza vaccine and with increased frequencies of the circulating pro-inflammatory B cell subset called Double Negative (DN) B cells. B cells from ET2DM patients are not only more inflammatory but also hyper-metabolic as compared to those from EH controls. The results herein are to our knowledge the first to show that T2DM superimposed on aging further increases systemic and B cell intrinsic inflammation, as well as dysfunctional humoral immunity. Our findings confirm and extend our previously published findings showing that inflammatory B cells are metabolically supported. [ABSTRACT FROM AUTHOR]- Published
- 2024
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