1. Protective effects of a novel water-soluble biphenyl compound WLP-S-14 against acute-on-chronic liver failure in rats.
- Author
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Wang, Shao-Yuan, Li, Mei, Miao, Lu-Yang, Wu, Song, Tong, Yuan-Feng, Zhang, Wen-Xuan, Zhang, Yu-Yang, and Sun, Hua
- Subjects
AMINOTRANSFERASES ,ANIMAL experimentation ,APOPTOSIS ,BIOMARKERS ,BIOCHEMISTRY ,BIOLOGICAL models ,BIPHENYL compounds ,BLOOD coagulation ,CARBOHYDRATES ,HISTOLOGICAL techniques ,INTERLEUKINS ,LIVER ,LIVER failure ,MOLECULAR structure ,MORTALITY ,PHYSIOLOGIC salines ,RATS ,SERUM ,SURVIVAL ,TUMOR necrosis factors ,WESTERN immunoblotting ,LIPOPOLYSACCHARIDES - Abstract
This study investigated the therapeutic effects of a water-soluble biphenyl compound, WLP-S-14, in acute-on-chronic liver failure (ACLF). Wistar rats were injected intraperitoneally with porcine serum twice a week for 8 weeks prior to administration of 600 mg/kg D-galactosamine and 50 μg/kg lipopolysaccharide to induce ACLF. Study groups were treated intravenously with saline or with 100 or 200 mg/kg WLP-S-14. WLP-S-14 ameliorated ACLF with significant reductions in the mortality rate and transaminase levels, indicating improved liver function. The mechanism underlying these effects may involve decreased levels of tumor necrosis factor-α and interleukin-6, with associated inhibition of apoptotic pathways. [ABSTRACT FROM AUTHOR]
- Published
- 2019
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