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The precautionary principle is often invoked in relation to pregnant women and may be one of the underlying reasons for their continuous underrepresentation in clinical research. The principle is appealing, because potential fetal harm as a result of research participation is considered to be serious and irreversible. In our paper, we explore through conceptual analysis whether and if so how the precautionary principle should apply to pregnant women. We argue that the principle is a decision-making strategy underlying risk-benefit decisions in clinical research, which can be applied to pregnant women. However, the current application is a strong one, leading to the promotion of absolute exclusion or, less often, absolute inclusion of pregnant women. In order to change this paralyzing situation, a shift toward weak precautionary thinking is necessary. Instead of automatic extreme precaution, a balance will be found between harms and potential benefits of including pregnant women in clinical research. [ABSTRACT FROM AUTHOR]

Background and objective: Donor selection criteria (DSC) are a vital link in the chain of supply of Substances of Human Origin (SoHO) but are also subject to controversy and differences of opinion. Traditionally, DSC have been based on application of the precautionary principle. Materials and methods: From 2017 to 2020, TRANSPOSE (TRANSfusion and transplantation PrOtection and SElection of donors), a European research project, aimed to identify discrepancies between current DSC by proposing a standardized risk assessment method for all SoHO (solid organs excluded) and all levels of evidence. Results: The current DSC were assessed using a modified risk assessment method based on the Alliance of Blood Operators' Risk‐based decision‐making framework for blood safety. It was found that with limited or diverging scientific evidence, it was difficult to reach consensus and an international standardized method for decision‐making was lacking. Furthermore, participants found it hard to disregard their local guidelines when providing expert opinion, which resulted in substantial influence on the consensus‐based decision‐making process. Conclusions: While the field of donation‐safety research is expanding rapidly, there is an urgent need to formalize the decision‐making process regarding DSC. This includes the need for standardized methods to increase transparency in the international decision‐making process and to ensure that this is performed consistently. Our framework provides an easy‐to‐implement approach for standardizing risk assessments, especially in the context of limited scientific evidence. [ABSTRACT FROM AUTHOR]

There is a significant gap between the safety management in the Chinese colleges and many renowned colleges in other countries. The subject of this study is how to assess the performance of health, safety, and environment (HSE) in Chinese college laboratories. The assessment system is established by three parts. First of all, HSE performance assessment indicators for laboratories in Chinese colleges are identified based on the previous studies. Then set valued iteration is used to calculate the weights of the various indicators. Following that, multiple attribute group decision-making (MAGDM) method with Pythagorean 2-tuple linguistic operators is used to assess the laboratory HSE performance in colleges. Finally, taking a college in Sichuan Province as an example, the proposed method is used to assess the laboratory HSE performance. The assessment result shows that the proposed method used in this study is practical and feasible. [ABSTRACT FROM AUTHOR]

An editorial is presented which discusses the study regarding the precautionary principles in massive transfusion protocols (MTPs) for trauma patients. It mentions the survey stating that trauma centers in the U.S. are maintaining thawed group A plasma to supplement AB plasma to be use as the initial resuscitation of trauma patients whose ABO status is unknown. It also expreses the public health issue within the transfusion community.

The ediotor focuses on study conducted by the researcher T.S. Rector on threats of precautionary principle including risk management and unintended consequences. Topics discussed include requirement to watch out unintended consequences of treatment as well as initiatives to avoid the same, determination of patient with dose-dependent QT interval prolongation by the U.S. Food & Drug Administration and absence of adequate information and adherence to the precautionary principle may lead to harms.