1. In-situ TiO2-x decoration of titanium carbide MXene for photo/sono-responsive antitumor theranostics.
- Author
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Zhang, Dong-Yang, Liu, Hengke, Younis, Muhammad Rizwan, Lei, Shan, Chen, Yunzhi, Huang, Peng, and Lin, Jing
- Subjects
TITANIUM carbide ,REACTIVE oxygen species ,COMPANION diagnostics ,MICROBUBBLE diagnosis ,BAND gaps ,ACOUSTIC imaging - Abstract
Background: Sonodynamic therapy (SDT) has emerged as a noninvasive therapeutic modality that involves sonosensitizers and low-intensity ultrasound. However, owing to the rapid recombination of charge carriers, most of the sonosensitizers triggered poor reactive oxygen species (ROS) generation, resulting in unsatisfactory sonodynamic therapeutic effects. Results: Herein, a photo/sono-responsive nanoplatform was developed through the in-situ systhesis of TiO
2-x on the surface of two-dimensional MXene (titanium carbide, Ti3 C2 ) for photoacoustic/photothermal bimodal imaging-guided near-infrared II (NIR-II) photothermal enhanced SDT of tumor. Because of several oxygen vacancies and smaller size (~ 10 nm), the in-situ formed TiO2-x nanoparticles possessed narrow band gap (2.65 eV) and high surface area, and thus served as a charge trap to restrict charge recombination under ultrasound (US) activation, resulting in enhanced sonodynamic ROS generation. Moreover, Ti3 C2 nanosheets induced extensive localized hyperthermia relieves tumor hypoxia by accelerating intratumoral blood flow and tumor oxygenation, and thus further strengthened the efficacy of SDT. Upon US/NIR-II laser dual-stimuli, Ti3 C2 @TiO2-x nanoplatform triggered substantial cellular killing in vitro and complete tumor eradication in vivo, without any tumor recurrence and systemic toxicity. Conclusion: Our work presents the promising design of photo/sono-responsive nanoplatform for cancer nanotheranostics. [ABSTRACT FROM AUTHOR]- Published
- 2022
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