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[Display omitted] Organotin(IV) complexes 2 and 4 exhibited strong cytostatic activity towards HeLa and HepG-2 cell lines. Meanwhile, the complex 4 exhibited much stronger inhibition against five common plant pathogenic fungi in vitro. Then, the scanning electron microscopy (SEM) and transmission electron microscopy (TEM) micrographs were used to study changes on the fungal morphology for the treatments with the complex 4, which indicated the complex 4 can damage the cell wall of mycelia. • The organotin(IV) complexes 1 – 4 formed varieties of supramolecular structures. • The organotin(IV) complexes 2 and 4 showed higher anticancer activities. • Complex 4 exhibited a broad spectrum of antifungal potential activity. • Complex 4 could break down the cell wall of the fungus. Four new organotin(IV) complexes, [(Me 2 Sn) 4 O 2 (C 10 H 10 F 2 NO 4 S) 4 ] (1), [(n -Bu 2 Sn) 4 O 2 (C 10 H 10 F 2 NO 4 S) 4 ] (2), [Me 3 SnC 10 H 10 F 2 NO 4 S] (3) and [ n -Bu 3 SnC 10 H 10 F 2 NO 4 S] (4) have been synthesized by the reactions of 2,6-difluoro-3-(propylsulfonamido)benzoic acid with R 2 SnO (R = Me, and n -Bu) or R 3 SnCl (R = Me, and n -Bu). The four complexes have been characterized by elemental analysis, FT-IR, NMR (1H, 13C and 119Sn), and X-ray crystallography. The X-ray crystallography analyses revealed that the complexes 1 and 2 represent tetranuclear tin ladder-like geometries. In comparison, complexes 3 and 4 exhibit 1D zig-zag chains. Complex 1 constructs a 2D planar structure by N H···O and C H···O intermolecular hydrogen bonding. Complex 2 constructs a 3D supramolecular framework via the C H···O and C H···F intermolecular hydrogen bonding. The 3D supramolecular frameworks of complexes 3 and 4 were formed by S O···H intermolecular hydrogen bonding, respectively. Furthermore, in vitro cytostatic activity of complexes 1 – 4 against the cervical carcinoma (HeLa) and the hepatocellular carcinoma (HepG-2) cell lines were examined by MTT screening. Results indicated that complexes 2 and 4 exhibited strong cytostatic activity. Meanwhile, the inhibition of complexes 1 – 4 against five common plant pathogenic fungi in vitro was obtained by the mycelial growth inhibition method, and the results revealed that complex 4 exhibited much stronger inhibition. The scanning electron microscopy (SEM) and transmission electron microscopy (TEM) micrographs were used to study changes on the fungal morphology for the treatments with complex 4. [ABSTRACT FROM AUTHOR]

Four new organotin complexes, [Me 3 SnO 2 SeC 6 H 4 -F-p] n ( 1 ), [Ph 3 SnO 2 SeC 6 H 4 -F-p] ( 2 ), [Me 2 Sn(O 2 SeC 6 H 4 -F-p) 2 ] n ( 3 ), and [(PhSn) 4 (μ 2 -O) 2 (O 2 SeC 6 H 4 -F-p) 8 ] ( 4 ) have been synthesized via reactions of 4-fluorobenzeneseleninato ligand and the corresponding R 3 SnCl or R 2 SnCl 2 (R = Me, Ph) with sodium ethoxide in methanol. All the complexes have been characterized by X-ray crystallography, elemental analysis, FT-IR, and NMR ( 1 H, 13 C, 119 Sn) spectroscopy. The structural analysis indicates that complex 1 adopts a 1D infinite zigzag chain structure, complex 2 displays a 1D infinite linear polymeric chain structure, complex 3 is 1D helical double-chain polymer containing eight-membered Sn 2 O 4 Se 2 inorganic ring, and complex 4 shows a tetranuclear cage structure containing two Sn–O–Sn motifs connected by bridging [p-F-C 6 H 4 SeO 2 ] - ligands. [ABSTRACT FROM AUTHOR]

ABSTRACT Six new arenetelluronic triorganotin esters, namely (R3Sn)4[ArTe(μ-O)(OH)O2)]2 (Ar = Ph, R = Me: 1, R = Ph: 2; Ar = 3-Me-Ph, R = Me: 3, R = Ph: 4, Ar = 3-Cl-Ph, R = Me: 5, R = Ph: 6), were prepared by treating arenetelluronic acids with the corresponding R3SnCl (R = Me, Ph) with potassium hydroxide in methanol. All complexes were characterized by elemental analysis, FT-IR, NMR (1H, 13C, 119Sn) spectroscopy, and X-ray crystallography. The structural analyses indicate that these complexes are isostructural as Sn4Te2 moiety, in which the Te2(μ2-O)2 units are situated in the center and each Te atom is coordinated with two OSnR3 groups on the side. Complexes 1, 3, and 5 show one-dimensional chain and two-dimensional network supramolecular structures by intermolecular CH···O or CH···Cl interactions. The antitumor activities of these complexes reveal that most arenetelluronic triorganotin esters have powerful antitumor activities with certain regularity. [ABSTRACT FROM AUTHOR]

• Diorganotin complexes show 2D network containing tetraorganodistannoxane units. • Organotin(IV) carboxylates with n -butyl and phenyl show higher antitumor activity. • Complexes 2 - 3 show lower cytotoxicity than organotin precursors in HBL-100 cells. • Complex 3 can lead to depolarization of mitochondrial membrane potential. • Complex 3 could induce cellular reactive oxygen species accumulation. Seven organotin(IV) complexes, [(R 3 Sn) 2 L] n (R = Me 1 , R = n -Bu 2), [(Ph 3 Sn) 2 L] (3), [(R 2 Sn) 2 L(μ 3 -O)] n (R = Me 4 , R = n -Bu 5), [R 2 SnL(1,10-phen)] n (R = Me 6), [(R 2 SnCl) 2 L(1,10-phen) 2 ] (R = n -Bu 7) derived from 1,4-naphthalenedicarboxylic acid (H 2 L) have been synthesized and characterized by elemental analysis, FT-IR, PXRD, NMR and X-ray crystallography. The single crystal diffraction reveals that complexes 1 and 2 represent 2D network structures, which both contain tetranuclear 26-membered macrocycles. Complexes 3 and 7 display dinuclear tin monomers, which can form 1D infinite chain by C-H ··· O and C-H ··· π interactions. Meanwhile, complexes 4 and 5 display 2D network containing tetraorganodistannoxane unit, while complex 6 adopts a 1D infinite chain structure, which further constructs 2D supramolecular architecture through C-H ··· O intermolecular interactions. What's more, in vitro cytostatic activity of the complexes 1 - 3 against cervical carcinoma cell lines (HeLa), hepatocellular carcinoma cell lines (HepG-2) and human normal breast cell lines (HBL-100) have been investigated, and the results show that organotin derivatives with n -butyl and phenyl group (2 and 3) exhibit significantly higher anticancer activity than complex 1 with methyl group. Meanwhile, organotin(IV) complexes (1 - 3) display lower cytotoxicity than corresponding organotin(IV) precursors [trimethyltin chloride, bis(tri- n -butyltin) oxide and triphenyltin chloride] in HBL-100 cells. Furthermore, cytostatic assessments of complex 3 against HepG-2 cells reveal that the effect of cytostatic and apoptotic may through ROS-mediated pathway. Image, graphical abstract [ABSTRACT FROM AUTHOR]

Six novel organotin (IV) complexes, [(Me3Sn)2(H2O)2L] (1), [(R3Sn)2L]n (R = Me 2, R = n‐Bu 3), [(Ph3Sn)2L] (4), [Me2SnL]n (5), [(Me2Sn)2L(μ3‐O)]n (6) have been designed and synthesized by the reactions of 4,4′‐oxybisbenzoic acid (H2L) and triorganotin (IV) chloride or oxide. All the complexes have been characterized by elemental analysis, FT‐IR, NMR, ESI‐Mass, PXRD and X‐ray crystallography. The single crystal diffraction reveals that complexes 1 and 4 represent dinuclear tin monomers. Complexes 2 and 3 display 2D network structure and 2D corrugated framework respectively, which both contain tetranuclear 36‐membered macrocycles. Furthermore, 2D structures are linked into a 3D supramolecular structures through intermolecular C‐H···π interactions. Complex 5 shows 1D infinite helical chain and further constructs 3D ladder supramolecular architecture through additional Sn···O and C‐H···O intermolecular interactions. Complex 6 displays 1D infinite polymeric chain containing 28‐membered macrocyclic ring. Preliminarily in vitro cytostatic activity studies on cervical carcinoma cell lines (HeLa) and hepatocellular carcinoma cell lines (HepG‐2) by MTT assay for some complexes reveal that complexes 3 and 4 exhibit high cytostatic activity. Further, complexes 3 and 4 were selected to investigate interactions of bovine serum albumin (BSA) by fluorescence quenching spectra and synchronous fluorescence spectra, which indicates that the complexes could quench the intrinsic fluorescence of BSA in a static quenching process. [ABSTRACT FROM AUTHOR]