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38 results on '"Altomare G"'

1. Design and expected performances of the large acceptance calorimeter for the HERD space mission

Author

Pacini, L., Adriani, O., Bai, Y. -L., Bao, T. -W., Berti, E., Bottai, S., Cao, W. -W., Casaus, J., Cui, X. -Z., D’Alessandro, R., Formato, V., Gao, J. -R., Li, R., Liu, X., Lorusso, L., Lyu, L. -W., Marin, J., Martinez, G., Pizzolotto, C., Qin, J. -J., Quan, Z., Shi, D. -L., Starodubtsev, O., Tang, Z. -C., Tiberio, A., Vagelli, V., Velasco, M. A., Wang, B., Wang, Hongmei, R. -J., Z. -G., Xu, M., Yang, Y., Zhang, L., Zheng, J. -K., Alemanno, F., Aloisio, R., Altomare, G., Ambrosi, G., An, Q., Antonelli, M., Azzarello, P., Bai, L., Bai, Y. L., Bao, T. W., Barbanera, M., Barbato, F. C. T., Bernardini, P., Berti, B., Bertucci, B., X. J., Bi, Bigongiari, G., Bongi, M., Bonvicini, V., Bordas, P., Bosch-Ramon, V., Brogi, P., Cadoux, F., Campana, D., Cao, W. W., Cao, Z., Catanzani, E., Cattaneo, P. W., Chang, J., Chang, Y. H., Chen, G. M., Chen, F., Cianetti, F., Comerma, A., Cortis, D., Cui, X. H., Cui, X. Z., Dai, C., Dai, Z. G., Gaetanoe, De, Mitri, De, Palma, De, Felice, Di, Giovanni, Di, Santo, Di, Venere, Di, Dong, L., Dong, J. N., Donvito, Y. W., Duranti, G., D’Urso, M., Evoli, D., Fang, C., Fariña, K., Favre, L., Feng, Y., Feng, C. Q., Feng, H., Feng, H. B., Finetti, Z. K., Formato, N., Frieden, V., Fusco, J. M., Gao, P., Gargano, J. R., Gascon-Fora, F., Gasparrini, D., Giglietto, D., Giovacchini, N., Gomez, F., Gong, S., Gou, K., Guida, Q. B., Guo, R., Guo, D. Y., Guo, J. H., Y. Q., He, H. H., Hu, H. B., Hu, J. Y., Hu, Hu, P., Huang, Y. M., Huang, G. S., Huang, J., Huang, W. H., Huang, X. T., Huang, Y. B., Ionica, Y. F., Jouvin, M., Kotenko, L., Kyratzis, A., Marra, La, Li, D., M. J., Li, Q. Y., Li, S. L., Li, Li, T., Li, X., Li, Z., Liang, Z. H., Liang, E. W., Liao, M. J., Licciulli, C. L., Lin, F., Liu, S. J., Liu, D., Liu, H. B., Liu, H., Liu, J. B., Liu, S. B., Liu, X. W., Loparco, Y. Q., Loporchio, F., Lu, S., Lyu, X., Lyu, J. G., Maestro, L. W., Mancini, E., Manera, E., Marin, R., Marrocchesi, J., Marsella, P. S., Marzullo, M., Mauricio, D., Mocchiutti, J., Morettini, G., Mori, G., Mussolin, L., Nicola, Mazziotta, Oliva, M., Orlandi, A., Osteria, D., Pacini, G., Panico, L., Pantalei, B., Papa, F. R., Papini, S., Paredes, P., Parenti, J. M., Pauluzzi, A., Pearce, M., Peng, M., Perfetto, W. X., Perrina, F., Perrotta, C., Pillera, G., Pizzolotto, R., Qiao, C., Qin, R., Quadrani, J. J., Quan, L., Rappoldi, Z., Raselli, A., Ren, G., Renno, X. X., Ribo, F., Rico, M., Rossella, J., Ryde, M., Sanmukh, F., Scotti, A., Serini, V., Shi, D., Shi, D. L., Silveri, Q. Q., Starodubtsev, L., Su, O., D. T., Su, Sukhonos, M., Suma, D., Sun, A., Sun, X. L., Surdo, Z. T., Tang, A., Tiberio, Z. C., Tykhonov, A., Vagelli, A., Vannuccini, V., Velasco, E., Walter, M., Wang, R., Wang, A. Q., Wang, J. C., Wang, J. M., Wang, J. J., Wang, L., Wang, M., Wang, R. J., Wang, S., Wang, X. Y., Wang, X. L., Wei, Z. G., Wei, D. M., J. J., Wu, B. B., Wu, Wu, J., L. B., Wu, Wu, X., Xin, X. F., Y. L., Xu, Yan, Z. Z., Yang, H. R., Yin, Y., P. F., Yu, Yuan, Y. W., Zampa, Q., Zampa, G., Zha, N., Zhang, M., Zhang, C., Zhang, F. Z., Zhang, L. F., Zhang, S. N., Zhang, Y., Zhao, Y. L., Zheng, Z. G., Zhou, J. K., Zhu, Y. L., Zhu, F. R., and K. J.

Subjects
Space experiments, Energy, Scintillating fiber, Performance, Monte Carlo methods, Measurements of, Space stations, Space missions, Cosmology, Cosmic rays, Intelligent systems, Scintillation counters, Silicon detectors, Charge detectors, Fiber trackers, Radiation detection, Read out systems, Calorimeters
Published
2022

2. The High Energy cosmic-Radiation Detector (HERD) Trigger System

Author

Velasco, M. A., Bao, T., Berti, E., Bonvicini, V., Casaus, J., Giovacchini, F., Liu, X., Marco, R., Marín, J., Martínez, G., Mori, N., Oliva, A., Pacini, L., Quan, Z., Tang, Z., Xu, M., Zampa, G., Zampa, N., Adriani, O., Alemanno, F., Aloisio, R., Altomare, G., Ambrosi, G., An, Q., Antonelli, M., Azzarello, P., Bai, L., Bai, Y. L., Bao, T. W., Barbanera, M., Barbato, F. C. T., Bernardini, B., Bertucci, B., X. J., Bi, Bigongiari, G., Bongi, M., Bordas, P., Bosch-Ramon, V., Bottai, S., Brogi, P., Cadoux, F., Campana, D., Cao, W. W., Cao, Z., Catanzani, E., Cattaneo, P. W., Chang, J., Chang, Y. H., Chen, G. M., Chen, F., Cianetti, F., Comerma, A., Cortis, D., Cui, X. H., Cui, X. Z., Dai, C., Dai, Z. G., D'Alessandro, R., Gaetanoe, De, Mitri, De, Palma, De, Felice, Di, Giovanni, Di, Santo, Di, Venere, Di, Dong, L., Dong, J. N., Donvito, Y. W., Duranti, G., D'Urso, M., Evoli, D., Fang, C., Fariña, K., Favre, L., Feng, Y., Feng, C. Q., Feng, H., Feng, H. B., Finetti, Z. K., Formato, N., Frieden, V., Fusco, J. M., Gao, P., Gargano, J. R., Gascon-Fora, F., Gasparrini, D., Giglietto, D., Gomez, N., Gong, S., Gou, K., Guida, Q. B., Guo, R., Guo, D. Y., Guo, J. H., Y. Q., He, H. H., Hu, H. B., Hu, J. Y., Hu, Hu, P., Huang, Y. M., Huang, G. S., Huang, J., Huang, W. H., Huang, X. T., Huang, Y. B., Ionica, Y. F., Jouvin, M., Kotenko, L., Kyratzis, A., Marra, La, Li, D., M. J., Li, Q. Y., Li, Li, R., S. L., Li, Li, T., Li, X., Li, Z., Liang, Z. H., Liang, E. W., Liao, M. J., Licciulli, C. L., Lin, F., Liu, S. J., Liu, D., Liu, H. B., Liu, H., Liu, J. B., Liu, S. B., Liu, X. W., Loparco, Y. Q., Loporchio, F., Lu, S., Lyu, X., Lyu, J. G., Maestro, L. W., Mancini, E., Manera, E., Marrocchesi, R., Marsella, P. S., Martinez, G., Marzullo, M., Mauricio, D., Mocchiutti, J., Morettini, G., Mussolin, L., Nicola, Mazziotta, Orlandi, M., Osteria, D., Panico, G., Pantalei, B., Papa, F. R., Papini, S., Paredes, P., Parenti, J. M., Pauluzzi, A., Pearce, M., Peng, M., Perfetto, W. X., Perrina, F., Perrotta, C., Pillera, G., Pizzolotto, R., Qiao, C., Qin, R., Quadrani, J. J., Rappoldi, L., Raselli, A., Ren, G., Renno, X. X., Ribo, F., Rico, M., Rossella, J., Ryde, M., Sanmukh, F., Scotti, A., Serini, V., Shi, D., Shi, D. L., Silveri, Q. Q., Starodubtsev, L., Su, O., D. T., Su, Sukhonos, M., Suma, D., Sun, A., Sun, X. L., Surdo, Z. T., Tang, A., Tiberio, Z. C., Tykhonov, A., Vagelli, A., Vannuccini, V., Velasco, E., Walter, M., Wang, R., Wang, A. Q., Wang, B., Wang, J. C., Wang, J. M., Wang, J. J., Wang, L., Wang, M., Wang, R. J., Wang, S., Wang, X. Y., Wang, X. L., Wei, Z. G., Wei, D. M., J. J., Wu, B. B., Wu, Wu, J., L. B., Wu, Wu, X., Xin, X. F., Y. L., Xu, Yan, Z. Z., Yang, H. R., Yin, Y., P. F., Yu, Yuan, Y. W., Zha, Q., Zhang, M., Zhang, C., Zhang, F. Z., Zhang, L., Zhang, L. F., Zhang, S. N., Zhang, Y., Zhao, Y. L., Zheng, Z. G., Zhou, J. K., Zhu, Y. L., Zhu, F. R., and K. J.

Subjects
Cosmology, Gamma rays, Intelligent systems, Monte Carlo methods, Space stations, Tellurium compounds, Topology, Dark matter, Electron spectrum, Energy, Fundamental physics, Measurements of, Plastic scintillator detector, Precise measurements, Radiation detection, Space-borne, Trigger systems, Cosmic rays
Published
2022

5. Latent tuberculosis infection in patients with chronic plaque psoriasis: evidence from the Italian Psocare Registry*

Author

Gisondi, P., Cazzaniga, S., Chimenti, S., Maccarone, M., Picardo, M., Girolomoni, G., Naldi, L., Griseta, V., Miracapillo, A., Azzini, M., Mocci, L., Michelini, M., Offidani, A., Bernardini, L., Campanati, A., Ricotti, G., Giacchetti, A., Norat, M., Gualco, F., Castelli, A., Cuccia, A., Diana, A., Roncarolo, G., Belli, M. A., Baldassarre, M. A., Santoro, G., Vena, G. A., Lo Console, F., Filotico, R., Mastrandrea, V., Brunetti, B., Musumeci, F., Carrabba, E., Dal Mas, P., Annicchiarico, F., Benvegnù, B., Spaziani, G., Cusano, F., Iannazzone, Saletta S., Galluccio, A., Pezza, M., Marchesi, L., Imberti, G., Reseghetti, A., Barbera, C., Reggiani, M., Lanzoni, A., Patrizi, A., Bardazzi, F., Antonucci, A., De Tommaso, S., Balestri, R., Wallnofer, W., Ingannamorte, F., Calzavara-Pinton, P., Iannazzi, S., Zane, C., Capezzera, R., Bassisi, S., Rossi, M. T., Altamura, V., Vigl, W., Nobile, C., Aste, N., Murgia, S., Mugheddu, C., Scuderi, G., Baglieri, F., Di Dio, C., Grilli, Cilioni E., Mastronardi, C., Agnusdei, C. P., Antrilli, A., Aulisa, L., Raimondo, U., di Luzio, Scotto G., Battarra, V. C., Farro, P., Plaitano, R., Micali, G., Musumeci, M. L., Massimino, D., Li Calzi, M., La Greca, S., Pettinato, M., Sapienza, G., Valenti, G., De Giacomo, P. F., dʼAmico, D., Arcangeli, F., Brunelli, D., Ghetti, E., Tulli, A., Assi, G., Laria, G., Prestinari, F., Spadafora, S., Coppola, M., Caresana, G., Pezzarossa, E., Domaneschi, E., Felisi, C., Donato, L., Bertero, M., Musso, L., Pa lazzini, S., Bruscino, P., Agozzino, U. C., Ottaviani, M., Simoncini, C., Virgili, A., Osti, F., Fabbri, P., Volpi, W., Caproni, M., Lotti, T., Prignano, F., Buggiani, G., Troiano, M., Fenizi, G., Altobella, A., Amoruso, A., Condello, M., Goffredo, A., Righini, M. G., Alessandrini, F., Satolli, F., Zampetti, M., Bertani, E., Fossati, S., Parodi, A., Burlando, M., Fiorucci, C., Nigro, A., Ghigliotti, G., Massone, L., Moise, G. M., Serrai, M., Cannata, G., Campagnoli, A. M., Daly, M., Leporati, C., Peila, R., Filosa, G., Bugatti, L., Nicolini, M., Nazzari, G., Cestari, R., Anastasio, F., Larussa, F. M., Pollice, N., De Francesco, F., Mazzocchetti, G., Peris, K., Fargnoli, M. C., Di Cesare, A., De Angelis, L., Flati, G., Biamonte, A. S., Quarta, G., Congedo, M., Carcaterra, A., Strippoli, D., Fideli, D., Marsili, F., Celli, M., Ceccarini, M., Bachini, L., DʼOria, M., Schirripa, V., De Filippi, C., Martini, P., Lapucci, E., Mazzatenta, C., Ghilardi, A., Simonacci, M., Bettacchi, A., Gasco, R., Zanca, A., Battistini, S., Dattola, S., Vernaci, R., Postorino, F., Zampieri, P. F., Padovan, C., González Intchaurraga, M. A., Ladurner, J., Guarneri, B., Cannavò, S., Manfrè, C., Borgia, F., Guerra, Puglisi A., Sedona, P., Cattaneo, A., Carrera, C., Fracchiolla, C., Mozzanica, N., Prezzemolo, L., Menni, S., Lodi, A., Martino, P., Monti, M., Mancini, L., Sacrini, F., Altomare, G. F., Taglioni, M., Lovati, C., Mercuri, S. R., Schiesari, G., Giannetti, A., Conti, A., Lasagni, C., Greco, M., Ronsini, G., Schianchi, S., Fiorentini, C., Niglietta, S., Maglietta, R., Padalino, C., Crippa, D., Pini, M., Rossi, E., Tosi, D., Armas, M., Ruocco, V., Ayala, F., Balato, N., Gaudiello, F., Cimmino, G. F., Monfrecola, G., Gallo, L., Argenziano, G., Fulgione, E., Berruti, G., Mozzillo, R., Ceparano, S., De Michele, I., Giorgiano, D., Leigheb, G., Deledda, S., Peserico, A., Alaibac, M., Piaserico, S., Schiesari, L., Dan, G., Mattei, I., Oro, E., Aricò, M., Bongiorno, M. R., Angileri, R., Amato, S., Todaro, F., Milioto, M., Bellastro, R., Di Nuzzo, S., De Panfilis, G., Zanni, M., Borroni, G., Cananzi, R., Brazzelli, V., Lisi, P., Stingeni, L., Hansel, K., Pierfelice, V., Donelli, S., Rastelli, D., Gasperini, M., Barachini, P., Cecchi, R., Bartoli, L., Pavesi, M., De Paola, S., Corradin, M. T., Ricciuti, F., Piccirillo, A., Viola, L., Tataranni, M., Mautone, M. G., Lo Scocco, G., Niccoli, M. C., Brunasso Vernetti, A. M.G., Gaddoni, G., Resta, F., Casadio, M. C., Arcidiaco, M. C., Luvarà, M. C., Albertini, G., Di Lernia, V., Guareschi, E., Catrani, S., Morri, M., Amerio, P., De Simone, C., DʼAgostino, M., Agostino, I., Calvieri, S., Cantoresi, F., Richetta, A., Sorgi, P., Carnevale, C., Nicolucci, F., Berardesca, E., Ardigò, M., De Felice, C., Gubinelli, E., Talamonti, M., Camplone, G., Cruciani, G., Riccardi, F., Barbati, R., Pagani, W., Malagoli, P. G., Pellicano, R., Donadio, D., Di Vito, C., Cottoni, F., Montesu, M. A., Pirodda, C., Addis, G., Marongiu, P., Farris, A., Cacciapuoti, M., Verrini, A., Desirello, G., Gnone, M., Fimiani, M., Pellegrino, M., Castelli, G., Zappalà, L., Sesana, G., Ingordo, V., Vozza, E., Di Giuseppe, D., Fasciocco, D., Nespoli, P., Papini, M., Cicoletti, M., Bernengo, M. G., Ortoncelli, M., Bonvicino, A., Capella, G., Doveil, G. C., Forte, M., Peroni, A., Salomone, B., Savoia, P., Pippione, M., Zichichi, L., Frazzitta, M., De Luca, G., Tasin, L., Simonetto, D., Ros, S., Trevisan, G., Patamia, M., Miertusova, S., Patrone, P., Frattasio, A., Piccirillo, F., La Spina, S., Di Gaetano, L., Marzocchi, V., Motolese, A., Venturi, C., Gai, F., Pasquinucci, S., Bellazzi, R. M., Silvestri, T., Fornasa, Veller C., and Trevisan, G. P.

Published
2015
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6. Increased frequency of activated CD8+ T cell effectors in patients with psoriatic arthritis

Author

Diani, M, Casciano, F, Marongiu, L, Longhi, M, Altomare, A, Pigatto, P, Secchiero, P, Gambari, R, Banfi, G, Manfredi, A, Altomare, G, Granucci, F, Reali, E, Diani M., Casciano F., Marongiu L., Longhi M., Altomare A., Pigatto P. D., Secchiero P., Gambari R., Banfi G., Manfredi A. A., Altomare G., Granucci F., Reali E., Diani, M, Casciano, F, Marongiu, L, Longhi, M, Altomare, A, Pigatto, P, Secchiero, P, Gambari, R, Banfi, G, Manfredi, A, Altomare, G, Granucci, F, Reali, E, Diani M., Casciano F., Marongiu L., Longhi M., Altomare A., Pigatto P. D., Secchiero P., Gambari R., Banfi G., Manfredi A. A., Altomare G., Granucci F., and Reali E.

Abstract

The aim of this study is to identify subsets of T cells differentially represented in the circulation of patients with psoriatic arthritis and to evaluate the possibility that they can recirculate between peripheral blood and the inflamed joints. We analyzed the phenotype and cytokine expression in circulating CD8+ and CD4+ T cells in 69 subjects: 28 with cutaneous psoriasis, 15 patients with psoriatic arthritis, and 26 healthy subjects. In the circulation, the percentage of each subset was compared among the groups and correlation was calculated with the serum concentration of C-reactive protein. To investigate the migration of T cells towards the inflamed joints, we performed a transwell migration assay towards patient serum and synovial fluid. In selected patients we analyzed in parallel T cells from peripheral blood and from synovial fluid. In the circulation, we found increased percentage of CD8+ CCR6+ T cell effectors expressing CD69 and of IL-17-producing T cells in patients with psoriatic arthritis. CD8+ effector/effector memory T cells showed increased migration towards synovial fluid. Finally, in synovial fluid we found accumulation of CXCR3+ CD8+ T cells and CD69+ cells. CD4+ T cells in the two compartments shared many similarities with CD8+ T cells. The results indicate a role for memory T cell effectors in systemic and joint manifestations of psoriatic arthritis.

Published
2019

8. Blood to skin recirculation of CD4+ memory T cells associates with cutaneous and systemic manifestations of psoriatic disease

Author

Diani, M, Galasso, M, Cozzi, C, Sgambelluri, F, Altomare, A, Cigni, C, Frigerio, E, Drago, L, Volinia, S, Granucci, F, Altomare, G, Reali, E, Diani M., Galasso M., Cozzi C., Sgambelluri F., Altomare A., Cigni C., Frigerio E., Drago L., Volinia S., Granucci F., Altomare G., Reali E., Diani, M, Galasso, M, Cozzi, C, Sgambelluri, F, Altomare, A, Cigni, C, Frigerio, E, Drago, L, Volinia, S, Granucci, F, Altomare, G, Reali, E, Diani M., Galasso M., Cozzi C., Sgambelluri F., Altomare A., Cigni C., Frigerio E., Drago L., Volinia S., Granucci F., Altomare G., and Reali E.

Abstract

Blood to skin recirculation could play a role in the pathogenesis of psoriasis. To investigate this possibility we dissected the phenotype of circulating T cells in psoriasis patients, calculated the correlation the clinical parameters of the disease and performed a parallel bioinformatics analysis of gene expression data in psoriatic skin. We found that circulating CCR6+ CD4+ TEM and TEFF cells significantly correlated with systemic inflammation. Conversely, the percentage of CXCR3+ CD4+ TEM cells negatively correlated with the severity of the cutaneous disease. Importantly CLA+ CD4+ TCM cells expressing CCR6+ or CCR4+ CXCR3+ negatively correlated with psoriasis severity suggesting recruitment to the skin compartment. This assumption was reinforced by gene expression data showing marked increase of CCR7 and CLA-encoding gene SELPLG expression in psoriatic skin and strong association of their expression. The data enlightens a role for CD4+ T cells trafficking between blood and skin in cutaneous and systemic manifestations of psoriasis.

Published
2017

9. Pruritus characteristics in a large Italian cohort of psoriatic patients

Author

Damiani, G., Cazzaniga, S., Conic, R. R. Z., Naldi, L., Griseta, V., Miracapillo, A., Azzini, M., Mocci, L., Michelini, M., Offidani, A., Bernardini, L., Campanati, A., Ricotti, G., Giacchetti, A., Norat, M., Gualco, F., Castelli, A., Cuccia, A., Diana, A., Roncarolo, G., Belli, M. A., Baldassarre, M. A., Santoro, G., Vena, G. A., Lo Console, F., Filotico, R., Mastrandrea, V., Brunetti, B., Musumeci, F., Carrabba, E., Dal Mas, P., Annicchiarico, F., Benvegnu, B., Spaziani, G., Cusano, F., Saletta Iannazzone, S., Galluccio, A., Pezza, M., Marchesi, L., Imberti, G., Reseghetti, A., Barbera, C., Reggiani, M., Lanzoni, A., Patrizi, A., Bardazzi, F., Antonucci, A., De Tommaso, S., Wallnofer, W., Ingannamorte, F., Calzavara-Pinton, P., Iannazzi, S., Zane, C., Capezzera, R., Bassisi, S., Rossi, M. T., Altamura, V., Vigl, W., Nobile, C., Aste, N., Murgia, S., Mugheddu, C., Scuderi, G., Baglieri, F., Di Dio, C., Cilioni Grilli, E., Mastronardi, C., Agnusdei, C. P., Antrilli, A., Aulisa, L., Raimondo, U., Scotto di Luzio, G., Battarra, V. C., Farro, P., Plaitano, R., Micali, G., Musumeci, M. L., Massimino, D., Li Calzi, M., La Greca, S., Pettinato, M., Sapienza, G., Valenti, G., De Giacomo, P. F., Amico, Arcangeli, F., Brunelli, D., Ghetti, E., Tulli, A., Assi, G., Amerio, P., Laria, G., Prestinari, F., Spadafora, S., Coppola, M., Caresana, G., Pezzarossa, E., Felisi, C., Donato, L., Bertero, M., Musso, L., Pa lazzini, S., Bruscino, P., Agozzino, U. C., Ottaviani, M., Simoncini, C., Virgili, A., Osti, F., Fabbri, P., Volpi, W., Caproni, M., Lotti, T., Prignano, F., Buggiani, G., Troiano, M., Fenizi, G., Altobella, A., Amoruso, A., Condello, M., Goffredo, A., Righini, M. G., Alessandrini, F., Satolli, F., Zampetti, M., Bertani, E., Fossati, S., Parodi, A., Burlando, M., Fiorucci, C., Nigro, A., Ghigliotti, G., Massone, L., Moise, G. M., Serrai, M., Cannata, G., Campagnoli, A. M., Daly, M., Leporati, C., Peila, R., Filosa, G., Bugatti, L., Nicolini, M., Nazzari, G., Cestari, R., Anastasio, F., Larussa, F. M., Pollice, N., De Francesco, F., Mazzocchetti, G., Peris, K., Fargnoli, M. C., Di Cesare, A., De Angelis, L., Flati, G., Biamonte, A. S., Quarta, G., Congedo, M., Carcaterra, A., Strippoli, D., Fideli, D., Marsili, F., Celli, M., Ceccarini, M., Bachini, L., D'Oria, M., Schirripa, V., De Filippi, C., Martini, P., Lapucci, E., Mazzatenta, C., Ghilardi, A., Simonacci, M., Bettacchi, A., Gasco, R., Zanca, A., Battistini, S., Dattola, S., Vernaci, R., Postorino, F., Zampieri, P. F., Padovan, C., Gonzalez Intchaurraga, M. A., Ladurner, J., Guarneri, B., Cannavo, S., Manfre, C., Borgia, F., Puglisi Guerra, A., Cattaneo, A., Carrera, C., Fracchiolla, C., Mozzanica, N., Prezzemolo, L., Menni, S., Lodi, A., Martino, P., Monti, M., Mancini, L., Sacrini, F., Altomare, G. F., Taglioni, M., Lovati, C., Mercuri, S. R., Schiesari, G., Giannetti, A., Conti, A., Lasagni, C., Greco, M., Ronsini, G., Schianchi, S., Fiorentini, C., Niglietta, S., Maglietta, R., Padalino, C., Crippa, D., Pini, M., Rossi, E., Tosi, D., Armas, M., Ruocco, V., Ayala, F., Balato, N., Gaudiello, F., Cimmino, G. F., Monfrecola, G., Gallo, L., Argenziano, G., Fulgione, E., Berruti, G., Ceparano, S., De Michele, I., Giorgiano, D., Leigheb, G., Deledda, S., Peserico, A., Alaibac, M., Piaserico, S., Schiesari, L., Dan, G., Mattei, I., Oro, E., Arico, M., Bongiorno, M. R., Angileri, R., Amato, S., Todaro, F., Milioto, M., Bellastro, R., Di Nuzzo, S., De Panfilis, G., Zanni, M., Borroni, G., Cananzi, R., Brazzelli, V., Lisi, P., Stingeni, L., Hansel, K., Pierfelice, V., Donelli, S., Rastelli, D., Gasperini, M., Barachini, P., Cecchi, R., Bartoli, L., Pavesi, M., De Paola, S., Corradin, M. T., Ricciuti, F., Piccirillo, A., Viola, L., Tataranni, M., Mautone, M. G., Lo Scocco, G., Niccoli, M. C., Brunasso Vernetti, A. M. G., Gaddoni, G., Resta, F., Casadio, M. C., Arcidiaco, M. C., Luvara, M. C., Albertini, G., Di Lernia, V., Guareschi, E., Catrani, S., Morri, M., De Simone, C., D'Agostino, M., Agostino, I., Calvieri, S., Cantoresi, F., Richetta, A., Sorgi, P., Carnevale, C., Nicolucci, F., Berardesca, E., Ardigo, M., De Felice, C., Gubinelli, E., Talamonti, M., Camplone, G., Cruciani, G., Riccardi, F., Barbati, R., Zumiani, G., Pagani, W., Malagoli, P. G., Pellicano, R., Donadio, D., Di Vito, C., Cottoni, F., Montesu, M. A., Pirodda, C., Addis, G., Marongiu, P., Farris, A., Cacciapuoti, M., Verrini, A., Desirello, G., Gnone, M., Fimiani, M., Pellegrino, M., Castelli, G., Zappala, L., Sesana, G., Ingordo, V., Vozza, E., Di Giuseppe, D., Fasciocco, D., Nespoli, P., Papini, M., Cicoletti, M., Bernengo, M. G., Ortoncelli, M., Bonvicino, A., Capella, G., Doveil, G. C., Forte, M., Peroni, A., Salomone, B., Savoia, P., Pippione, M., Zichichi, L., Frazzitta, M., De Luca, G., Tasin, L., Simonetto, D., Ros, S., Trevisan, G., Patamia, M., Miertusova, S., Patrone, P., Frattasio, A., Piccirillo, F., La Spina, S., Di Gaetano, L., Marzocchi, V., Motolese, A., Venturi, C., Gai, F., Pasquinucci, S., Bellazzi, R. M., Silvestri, T., Girolomoni, G., Gisondi, P., Veller Fornasa, C., Trevisan, G. P., Damiani G., Cazzaniga S., Conic R.R.Z., Naldi L., Griseta V., Miracapillo A., Azzini M., Mocci L., Michelini M., Offidani A., Bernardini L., Campanati A., Ricotti G., Giacchetti A., Norat M., Gualco F., Castelli A., Cuccia A., Diana A., Roncarolo G., Belli M.A., Baldassarre M.A., Santoro G., Vena G.A., Lo Console F., Filotico R., Mastrandrea V., Brunetti B., Musumeci F., Carrabba E., Dal Mas P., Annicchiarico F., Benvegnu B., Spaziani G., Cusano F., Saletta Iannazzone S., Galluccio A., Pezza M., Marchesi L., Imberti G., Reseghetti A., Barbera C., Reggiani M., Lanzoni A., Patrizi A., Bardazzi F., Antonucci A., De Tommaso S., Wallnofer W., Ingannamorte F., Calzavara-Pinton P., Iannazzi S., Zane C., Capezzera R., Bassisi S., Rossi M.T., Altamura V., Vigl W., Nobile C., Aste N., Murgia S., Mugheddu C., Scuderi G., Baglieri F., Di Dio C., Cilioni Grilli E., Mastronardi C., Agnusdei C.P., Antrilli A., Aulisa L., Raimondo U., Scotto di Luzio G., Battarra V.C., Farro P., Plaitano R., Micali G., Musumeci M.L., Massimino D., Li Calzi M., La Greca S., Pettinato M., Sapienza G., Valenti G., De Giacomo P.F., Amico, Arcangeli F., Brunelli D., Ghetti E., Tulli A., Assi G., Amerio P., Laria G., Prestinari F., Spadafora S., Coppola M., Caresana G., Pezzarossa E., Felisi C., Donato L., Bertero M., Musso L., Pa lazzini S., Bruscino P., Agozzino U.C., Ottaviani M., Simoncini C., Virgili A., Osti F., Fabbri P., Volpi W., Caproni M., Lotti T., Prignano F., Buggiani G., Troiano M., Fenizi G., Altobella A., Amoruso A., Condello M., Goffredo A., Righini M.G., Alessandrini F., Satolli F., Zampetti M., Bertani E., Fossati S., Parodi A., Burlando M., Fiorucci C., Nigro A., Ghigliotti G., Massone L., Moise G.M., Serrai M., Cannata G., Campagnoli A.M., Daly M., Leporati C., Peila R., Filosa G., Bugatti L., Nicolini M., Nazzari G., Cestari R., Anastasio F., Larussa F.M., Pollice N., De Francesco F., Mazzocchetti G., Peris K., Fargnoli M.C., Di Cesare A., De Angelis L., Flati G., Biamonte A.S., Quarta G., Congedo M., Carcaterra A., Strippoli D., Fideli D., Marsili F., Celli M., Ceccarini M., Bachini L., D'Oria M., Schirripa V., De Filippi C., Martini P., Lapucci E., Mazzatenta C., Ghilardi A., Simonacci M., Bettacchi A., Gasco R., Zanca A., Battistini S., Dattola S., Vernaci R., Postorino F., Zampieri P.F., Padovan C., Gonzalez Intchaurraga M.A., Ladurner J., Guarneri B., Cannavo S., Manfre C., Borgia F., Puglisi Guerra A., Cattaneo A., Carrera C., Fracchiolla C., Mozzanica N., Prezzemolo L., Menni S., Lodi A., Martino P., Monti M., Mancini L., Sacrini F., Altomare G.F., Taglioni M., Lovati C., Mercuri S.R., Schiesari G., Giannetti A., Conti A., Lasagni C., Greco M., Ronsini G., Schianchi S., Fiorentini C., Niglietta S., Maglietta R., Padalino C., Crippa D., Pini M., Rossi E., Tosi D., Armas M., Ruocco V., Ayala F., Balato N., Gaudiello F., Cimmino G.F., Monfrecola G., Gallo L., Argenziano G., Fulgione E., Berruti G., Ceparano S., De Michele I., Giorgiano D., Leigheb G., Deledda S., Peserico A., Alaibac M., Piaserico S., Schiesari L., Dan G., Mattei I., Oro E., Arico M., Bongiorno M.R., Angileri R., Amato S., Todaro F., Milioto M., Bellastro R., Di Nuzzo S., De Panfilis G., Zanni M., Borroni G., Cananzi R., Brazzelli V., Lisi P., Stingeni L., Hansel K., Pierfelice V., Donelli S., Rastelli D., Gasperini M., Barachini P., Cecchi R., Bartoli L., Pavesi M., De Paola S., Corradin M.T., Ricciuti F., Piccirillo A., Viola L., Tataranni M., Mautone M.G., Lo Scocco G., Niccoli M.C., Brunasso Vernetti A.M.G., Gaddoni G., Resta F., Casadio M.C., Arcidiaco M.C., Luvara M.C., Albertini G., Di Lernia V., Guareschi E., Catrani S., Morri M., De Simone C., D'Agostino M., Agostino I., Calvieri S., Cantoresi F., Richetta A., Sorgi P., Carnevale C., Nicolucci F., Berardesca E., Ardigo M., De Felice C., Gubinelli E., Talamonti M., Camplone G., Cruciani G., Riccardi F., Barbati R., Zumiani G., Pagani W., Malagoli P.G., Pellicano R., Donadio D., Di Vito C., Cottoni F., Montesu M.A., Pirodda C., Addis G., Marongiu P., Farris A., Cacciapuoti M., Verrini A., Desirello G., Gnone M., Fimiani M., Pellegrino M., Castelli G., Zappala L., Sesana G., Ingordo V., Vozza E., Di Giuseppe D., Fasciocco D., Nespoli P., Papini M., Cicoletti M., Bernengo M.G., Ortoncelli M., Bonvicino A., Capella G., Doveil G.C., Forte M., Peroni A., Salomone B., Savoia P., Pippione M., Zichichi L., Frazzitta M., De Luca G., Tasin L., Simonetto D., Ros S., Trevisan G., Patamia M., Miertusova S., Patrone P., Frattasio A., Piccirillo F., La Spina S., Di Gaetano L., Marzocchi V., Motolese A., Venturi C., Gai F., Pasquinucci S., Bellazzi R.M., Silvestri T., Girolomoni G., Gisondi P., Veller Fornasa C., and Trevisan G.P.

Subjects
Male, Cross-sectional study, Severity of Illness Index, Cohort Studies, 030207 dermatology & venereal diseases, 0302 clinical medicine, Risk Factors, education, itch, pruritus, psoriasis, pustular psoriasis, treatment, Adolescent, Adult, Cross-Sectional Studies, Educational Status, Facial Dermatoses, Female, Foot Dermatoses, Genitalia, Hand Dermatoses, Humans, Italy, Middle Aged, Pruritus, Psoriasis, Registries, Sex Factors, Young Adult, Epidemiology, Young adult, skin and connective tissue diseases, Settore MED/33 - MALATTIE APPARATO LOCOMOTORE, Infectious Diseases, 030220 oncology & carcinogenesis, Cohort, PRURITIS EPIDEMIOLOGY, Settore MED/35 - MALATTIE CUTANEE E VENEREE, Cohort study, medicine.medical_specialty, PSORIAS, Dermatology, Article, 03 medical and health sciences, Pharmacotherapy, Settore MED/35, Severity of illness, medicine, business.industry, medicine.disease, Pruritus,Itch sensation, business
Abstract

Background: Psoriasis (Ps) is a chronic systemic autoimmune disease associated with pruritus in 64–98% of patients. However, few modestly sized studies assess factors associated with psoriatic pruritus. Objective: To investigate factors associated with Ps pruritus intensity. Methods: Psoriasis patients 18years or older seen in one of 155 centres in Italy between September 2005 and 2009 were identified from the Italian PsoCare registry. Patients without cutaneous psoriasis and those with missed information on pruritus were excluded. Results: We identified 10802 patients, with a mean age 48.8±14.3years. Mild itch was present in 33.2% of patients, moderate in 34.4%, severe in 18.7% and very severe in 13.7%. Higher itch intensity was associated with female gender, lower educational attainment compared to university degree, pustular psoriasis, psoriasis on the head, face, palmoplantar areas, folds and genitalia, more severe disease, disease duration

Published
2019

10. Consensus on the management of patients with psoriatic arthritis in a dermatology setting

Author

Gisondi, P., Altomare, G., Ayala, F., Conti, A., Dapavo, P., De Simone, Clara, Foti, C., Idolazzi, L., Lubrano, E., Malara, G., Marchesoni, A., Olivieri, I., Parodi, A., Peris, Ketty, Piaserico, S., Salvarani, C., Scarpa, R., Girolomoni, G., De Simone, C. (ORCID:0000-0002-0898-0045), Peris, K. (ORCID:0000-0002-5237-0463), Gisondi, P., Altomare, G., Ayala, F., Conti, A., Dapavo, P., De Simone, Clara, Foti, C., Idolazzi, L., Lubrano, E., Malara, G., Marchesoni, A., Olivieri, I., Parodi, A., Peris, Ketty, Piaserico, S., Salvarani, C., Scarpa, R., Girolomoni, G., De Simone, C. (ORCID:0000-0002-0898-0045), and Peris, K. (ORCID:0000-0002-5237-0463)

Abstract

Background: Psoriatic arthritis (PsA) is a chronic inflammatory disease associated with psoriasis (PsO). Early diagnosis and prompt therapeutic intervention are crucial for limiting PsA progression and prevention of disability. Dermatologists are in a privileged position to detect early PsA. The management of patients with PsA in the dermatology setting is widely variable. Objective: To provide practical recommendations for the management of patients with PsA in the dermatology setting including early diagnosis and treatment. Methods: A consensus document was written by an expert panel composed by dermatologists (n = 12) and rheumatologists (n = 6). Eleven highly relevant questions were selected and elaborated with answers/statements based on a narrative literature review. The resulting document was discussed in a face-to-face meeting adopting a nominal group technique to reach consensus (i.e. 100% agreement) using the Delphi method. Results: A consensus was achieved in defining the following: the clinical characteristics differentiating inflammatory and non-inflammatory signs and symptoms of joint disease; the most important differential diagnoses of PsA in clinical practice; the most useful screening questionnaires, serum laboratory tests and imaging techniques for the detection of early PsA; the criteria for dermatologist to refer patients with PsO to rheumatologist; the criteria for the diagnosis of PsA; the selection of the indices that the dermatologist could use for measuring the activity and severity of PsA in clinical practice; when systemic steroids and/or intra-articular steroid injections are indicated in the treatment of PsA. Finally, systemic treatments including synthetic and biologic disease-modifying antirheumatic drugs to be considered for the treatment of PsA have been reported. Conclusions: The implementations of these practical recommendations could be very helpful for the management of patients with PsA in the dermatology setting including earl

Published
2018

11. Consensus on the management of patients with psoriatic arthritis in a dermatology setting

Author

Gisondi, P., primary, Altomare, G., additional, Ayala, F., additional, Conti, A., additional, Dapavo, P., additional, De Simone, C., additional, Foti, C., additional, Idolazzi, L., additional, Lubrano, E., additional, Malara, G., additional, Marchesoni, A., additional, Olivieri, I., additional, Parodi, A., additional, Peris, K., additional, Piaserico, S., additional, Salvarani, C., additional, Scarpa, R., additional, and Girolomoni, G., additional

Published
2018
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12. Italian guidelines on the systemic treatments of moderate-to-severe plaque psoriasis

Author

Gisondi, P., Altomare, G., Ayala, F., Bardazzi, F., Bianchi, L., Chiricozzi, Andrea, Costanzo, Rosa Maria Alba, Conti, A., Dapavo, P., De Simone, Clara, Foti, C., Naldi, L., Offidani, A., Parodi, A., Piaserico, S., Prignano, F., Rongioletti, F., Stingeni, L., Talamonti, M., Girolomoni, G., Chiricozzi, A. (ORCID:0000-0002-6739-0387), De Simone, C. (ORCID:0000-0002-0898-0045), Gisondi, P., Altomare, G., Ayala, F., Bardazzi, F., Bianchi, L., Chiricozzi, Andrea, Costanzo, Rosa Maria Alba, Conti, A., Dapavo, P., De Simone, Clara, Foti, C., Naldi, L., Offidani, A., Parodi, A., Piaserico, S., Prignano, F., Rongioletti, F., Stingeni, L., Talamonti, M., Girolomoni, G., Chiricozzi, A. (ORCID:0000-0002-6739-0387), and De Simone, C. (ORCID:0000-0002-0898-0045)

Abstract

Psoriasis is a common disease, which has a considerable impact on the healthcare system. Therefore, appropriate use of therapeutic resources is very important. Management of psoriasis in daily clinical practice is highly variable because many issues are still debated and not definitely addressed by the evidence-based medicine. Moreover, the different availability and reimbursability of drugs in each country justifies national guidelines. Expert consensus can provide helpful guidelines for optimizing patient care. A total of 20 dermatologists from different areas of Italy and with large experience in the treatment of psoriasis agreed to participate in the guidelines expert panel who aimed to reach consensus on the factors influencing psoriasis severity, the indications for systemic treatments, the parameters to be considered in the choice of treatment, and the factors to be considered in the choice of biological treatment. The recommendations for the use, screening and monitoring of systemic therapies were based on the 2015 S3 European Dermatology Forum/European Academy of Dermatology and Venereology psoriasis guidelines. Recommendations on the treatment of psoriasis in special patient populations were also agreed. The final document was discussed in a meeting moderated by a facilitator with participation of the entire group and adopting a nominal group technique to reach consensus. A statement was regarded as consented when agreement was achieved by at least 75% of the voting experts according to the Delphi procedure.

Published
2017

13. Italian guidelines on the systemic treatments of moderate‐to‐severe plaque psoriasis

Author

Gisondi, P., primary, Altomare, G., additional, Ayala, F., additional, Bardazzi, F., additional, Bianchi, L., additional, Chiricozzi, A., additional, Costanzo, A., additional, Conti, A., additional, Dapavo, P., additional, De Simone, C., additional, Foti, C., additional, Naldi, L., additional, Offidani, A., additional, Parodi, A., additional, Piaserico, S., additional, Prignano, F., additional, Rongioletti, F., additional, Stingeni, L., additional, Talamonti, M., additional, and Girolomoni, G., additional

Published
2017
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14. A role for CCR5+CD4 T cells in cutaneous psoriasis and for CD103+ CCR4+ CD8 Teff cells in the associated systemic inflammation

Author

Sgambelluri, F, Diani, M, Altomare, A, Frigerio, E, Drago, L, Granucci, F, Banfi, G, Altomare, G, Reali, E, GRANUCCI, FRANCESCA, BANFI, GIUSEPPE, REALI, EVA, Sgambelluri, F, Diani, M, Altomare, A, Frigerio, E, Drago, L, Granucci, F, Banfi, G, Altomare, G, Reali, E, GRANUCCI, FRANCESCA, BANFI, GIUSEPPE, and REALI, EVA

Abstract

Recent results have identified critical components of the T cell response involved in the initiation and amplification phases of psoriasis. However the link between T cell responses arising in the skin and the systemic inflammation associated with severe psoriasis is largely unknown. We hypothesized that specific subsets of memory T cells recirculating from the skin could play a role. We therefore dissected the circulating memory T cell compartment in patients by analyzing the TCM, TEM and Teff phenotype, the pattern of CCR4 and CCR5 chemokine receptor expression and the expression of the tissue homing molecule CD103. For each subset we calculated the correlation with the Psoriasis Area and Severity Index (PASI) and with the extent of systemic inflammation measured as serum level of the prototypic short pentraxin, C reactive protein (CRP). Validation was performed by comparison with gene expression data in psoriatic plaques. We found that circulating CD103+CCR4+CCR5+ and CCR4+CCR6- CD8+ Teff cells, were highly correlated with CRP levels as well as with the validated index PASI, reflecting a link between skin involvement and systemic inflammation in patients with severe psoriasis. In addition we observed a contraction of circulating CCR5+ T cells in psoriasis patients, with a highly significant inverse correlation between CCR5+CD4 T cells and the PASI score. Increased expression of CCR5 and CCL5 genes in psoriatic skin lesions was consistent with an accumulation of CCR5+ cells in psoriatic plaques indicating a role for CCR5/CCL5 axis in disease pathogenesis.

Published
2016

16. Increased frequency of activated CD8+ T cell effectors in patients with psoriatic arthritis

Author

Francesca Granucci, Paola Secchiero, Roberto Gambari, Andrea Altomare, Eva Reali, Angelo A. Manfredi, Laura Marongiu, Gianfranco Altomare, Matteo Longhi, Paolo D. Pigatto, Marco Diani, Giuseppe Banfi, Fabio Casciano, Diani, M, Casciano, F, Marongiu, L, Longhi, M, Altomare, A, Pigatto, P, Secchiero, P, Gambari, R, Banfi, G, Manfredi, A, Altomare, G, Granucci, F, Reali, E, Diani, M., Casciano, F., Marongiu, L., Longhi, M., Altomare, A., Pigatto, P. D., Secchiero, P., Gambari, R., Banfi, G., Manfredi, A. A., Altomare, G., Granucci, F., and Reali, E.

Subjects
0301 basic medicine, T cell, Arthritis, lcsh:Medicine, NO, 03 medical and health sciences, Psoriatic arthritis, 0302 clinical medicine, Antigen, medicine, Synovial fluid, Cytotoxic T cell, lcsh:Science, psoriatic arthritis, Multidisciplinary, psoriasis, T cells, business.industry, lcsh:R, autoimmunity, medicine.disease, psoriatic arthritis, autoimmunity, inflammation, 030104 developmental biology, medicine.anatomical_structure, inflammation, Immunology, lcsh:Q, business, Memory T cell, 030217 neurology & neurosurgery, CD8
Abstract

The aim of this study is to identify subsets of T cells differentially represented in the circulation of patients with psoriatic arthritis and to evaluate the possibility that they can recirculate between peripheral blood and the inflamed joints. We analyzed the phenotype and cytokine expression in circulating CD8+ and CD4+ T cells in 69 subjects: 28 with cutaneous psoriasis, 15 patients with psoriatic arthritis, and 26 healthy subjects. In the circulation, the percentage of each subset was compared among the groups and correlation was calculated with the serum concentration of C-reactive protein. To investigate the migration of T cells towards the inflamed joints, we performed a transwell migration assay towards patient serum and synovial fluid. In selected patients we analyzed in parallel T cells from peripheral blood and from synovial fluid. In the circulation, we found increased percentage of CD8+ CCR6+ T cell effectors expressing CD69 and of IL-17-producing T cells in patients with psoriatic arthritis. CD8+ effector/effector memory T cells showed increased migration towards synovial fluid. Finally, in synovial fluid we found accumulation of CXCR3+ CD8+ T cells and CD69+ cells. CD4+ T cells in the two compartments shared many similarities with CD8+ T cells. The results indicate a role for memory T cell effectors in systemic and joint manifestations of psoriatic arthritis.

Published
2019

17. Differences in Osteoimmunological Biomarkers Predictive of Psoriatic Arthritis among a Large Italian Cohort of Psoriatic Patients

Author

Paolo D. Pigatto, Veronica Sansoni, Marta Gomarasca, Marco Diani, Giovanni Damiani, Giovanni Lombardi, Silvia Perego, Lucrezia Bertino, Giuseppe Banfi, Martina Faraldi, Gianfranco Altomare, Diani, M., Perego, S., Sansoni, V., Bertino, L., Gomarasca, M., Faraldi, M., Pigatto, P. D. M., Damiani, G., Banfi, G., Altomare, G., and Lombardi, G.

Subjects
Male, 0301 basic medicine, Bone resorption, MMP8, Gastroenterology, lcsh:Chemistry, chemistry.chemical_compound, 0302 clinical medicine, lcsh:QH301-705.5, Spectroscopy, Aged, 80 and over, psoriatic arthritis, Osteoimmunological markers, General Medicine, psoriasis, Middle Aged, Computer Science Applications, osteoimmunological markers, Psoriatic arthritis, Female, bone resorption, Adult, medicine.medical_specialty, Article, Catalysis, CHI3L1, Diagnosis, Differential, Inorganic Chemistry, Young Adult, 03 medical and health sciences, N-terminal telopeptide, Predictive Value of Tests, Internal medicine, Psoriasis, medicine, Humans, Physical and Theoretical Chemistry, Molecular Biology, Pathological, Aged, 030203 arthritis & rheumatology, business.industry, Arthritis, Psoriatic, Organic Chemistry, medicine.disease, 030104 developmental biology, ROC Curve, chemistry, lcsh:Biology (General), lcsh:QD1-999, Case-Control Studies, Sclerostin, business, Biomarkers, Follow-Up Studies
Abstract

(1) Background: In literature it is reported that 20&ndash, 30% of psoriatic patients evolve to psoriatic arthritis over time. Currently, no specific biochemical markers can either predict progression to psoriatic arthritis or response to therapies. This study aimed to identify osteoimmunological markers applicable to clinical practice, giving a quantitative tool for evaluating pathological status and, eventually, to provide prognostic support in diagnosis. (2) Methods: Soluble (serum) bone and cartilage markers were quantified in 50 patients with only psoriasis, 50 psoriatic patients with psoriatic arthritis, and 20 healthy controls by means of multiplex and enzyme-linked immunoassays. (3) Results: Differences in the concentrations of matrix metalloproteases (MMPs), tissue inhibitors of metalloproteinases (TIMPs), receptor activator of nuclear factor kappa-B- ligand (RANK-L), procollagen type I N propeptide (PINP), C-terminal telopeptide of type I collagen (CTx-I), dickkopf-related protein 1 (DKK1), and sclerostin (SOST) distinguished healthy controls from psoriasis and psoriatic arthritis patients. We found that MMP2, MMP12, MMP13, TIMP2, and TIMP4 distinguished psoriasis from psoriatic arthritis patients undergoing a systemic treatment, with a good diagnostic accuracy (Area under the ROC Curve (AUC) &gt, 0.7). Then, chitinase-3-like protein 1 (CHI3L1) and MMP10 distinguished psoriasis from psoriatic arthritis not undergoing systemic therapy and, in the presence of onychopathy, MMP8 levels were higher in psoriasis than in psoriatic arthritis. However, in these latter cases, the diagnostic accuracy of the identified biomarkers was low (0.5 &lt, AUC &lt, 0.7). (4) Conclusions. By highlighting never exploited differences, the wide osteoimmunological biomarkers panel provides a novel clue to the development of diagnostic paths in psoriasis and psoriasis-associated arthropathic disease.

Published
2019

18. Italian guidelines on the systemic treatments of moderate-to-severe plaque psoriasis

Author

Luca Bianchi, Francesca Prignano, Andrea Chiricozzi, Luigi Naldi, Fabio Ayala, Caterina Foti, Paolo Gisondi, Giampiero Girolomoni, Gianfranco Altomare, Luca Stingeni, Stefano Piaserico, Federico Bardazzi, A. Offidani, Andrea Parodi, Marina Talamonti, C. De Simone, Andrea Conti, Antonio Costanzo, Paolo Dapavo, Franco Rongioletti, Gisondi, P, Altomare, G, Ayala, Fabio, Bardazzi, F, Bianchi, L, Chiricozzi, A, Costanzo, A, Conti, A, Dapavo, P, De Simone, C, Foti, Lidia, Naldi, L, Offidani, A, Parodi Giusino, Ugo, Piaserico, S, Prignano, F, Rongioletti, F, Stingeni, L, Talamonti, M, Girolomoni, G., Ayala, F, Foti, C, Parodi, A, and Girolomoni, G

Subjects
medicine.medical_specialty, Pathology, MONOCLONAL-ANTIBODY, BIOLOGIC THERAPIES, LONG-TERM, HEPATITIS-B, Alternative medicine, MEDLINE, Italian guidelines, Dermatology, Severity of Illness Index, Italian guidelines, moderate-to-severe plaque psoriasis, law.invention, 030207 dermatology & venereal diseases, 03 medical and health sciences, 0302 clinical medicine, Randomized controlled trial, law, Infectious Diseases, LATENT TUBERCULOSIS INFECTION, Psoriasis, Nominal group technique, Severity of illness, medicine, Humans, Evidence-Based Medicine, business.industry, Italy, 2708, RANDOMIZED CONTROLLED-TRIAL, INFLAMMATORY-BOWEL-DISEASE, DOUBLE-BLIND TRIAL, PHASE-III, ERYTHRODERMIC PSORIASIS, Evidence-based medicine, medicine.disease, moderate-to-severe plaque psoriasis, 030220 oncology & carcinogenesis, Facilitator, Family medicine, business, Settore MED/35 - MALATTIE CUTANEE E VENEREE
Abstract

Psoriasis is a common disease, which has a considerable impact on the healthcare system. Therefore, appropriate use of therapeutic resources is very important. Management of psoriasis in daily clinical practice is highly variable because many issues are still debated and not definitely addressed by the evidence-based medicine. Moreover, the different availability and reimbursability of drugs in each country justifies national guidelines. Expert consensus can provide helpful guidelines for optimizing patient care. A total of 20 dermatologists from different areas of Italy and with large experience in the treatment of psoriasis agreed to participate in the guidelines expert panel who aimed to reach consensus on the factors influencing psoriasis severity, the indications for systemic treatments, the parameters to be considered in the choice of treatment, and the factors to be considered in the choice of biological treatment. The recommendations for the use, screening and monitoring of systemic therapies were based on the 2015 S3 European Dermatology Forum/European Academy of Dermatology and Venereology psoriasis guidelines. Recommendations on the treatment of psoriasis in special patient populations were also agreed. The final document was discussed in a meeting moderated by a facilitator with participation of the entire group and adopting a nominal group technique to reach consensus. A statement was regarded as consented when agreement was achieved by at least 75% of the voting experts according to the Delphi procedure.

Published
2017

19. Blood to skin recirculation of CD4+ memory T cells associates with cutaneous and systemic manifestations of psoriatic disease

Author

E. Frigerio, Gianfranco Altomare, Andrea Altomare, Marco Galasso, Eva Reali, Francesca Granucci, Francesco Sgambelluri, Clara Cigni, Marco Diani, Stefano Volinia, Chiara Cozzi, Lorenzo Drago, Diani, M, Galasso, M, Cozzi, C, Sgambelluri, F, Altomare, A, Cigni, C, Frigerio, E, Drago, L, Volinia, S, Granucci, F, Altomare, G, and Reali, E

Subjects
0301 basic medicine, Adult, Antigens, Differentiation, T-Lymphocyte, Male, Pathology, medicine.medical_specialty, Immunology, C-C chemokine receptor type 6, Systemic inflammation, CXCR3, Severity of Illness Index, Pathogenesis, 03 medical and health sciences, Interleukin 21, Young Adult, Antigen, Psoriasis, medicine, Immunology and Allergy, Cytokine, Skin, Psoriasi, integumentary system, biology, business.industry, C-reactive protein, Middle Aged, medicine.disease, 030104 developmental biology, C-Reactive Protein, CD4-Positive T-Lymphocyte, biology.protein, Female, Receptors, Chemokine, Membrane Glycoprotein, medicine.symptom, business, Immunologic Memory, Human
Abstract

Blood to skin recirculation could play a role in the pathogenesis of psoriasis. To investigate this possibility we dissected the phenotype of circulating T cells in psoriasis patients, calculated the correlation the clinical parameters of the disease and performed a parallel bioinformatics analysis of gene expression data in psoriatic skin. We found that circulating CCR6+ CD4+ TEM and TEFF cells significantly correlated with systemic inflammation. Conversely, the percentage of CXCR3+ CD4+ TEM cells negatively correlated with the severity of the cutaneous disease. Importantly CLA+ CD4+ TCM cells expressing CCR6+ or CCR4+CXCR3+ negatively correlated with psoriasis severity suggesting recruitment to the skin compartment. This assumption was reinforced by gene expression data showing marked increase of CCR7 and CLA-encoding gene SELPLG expression in psoriatic skin and strong association of their expression. The data enlightens a role for CD4+ T cells trafficking between blood and skin in cutaneous and systemic manifestations of psoriasis.

Published
2017

20. A role for CCR5(+)CD4 T cells in cutaneous psoriasis and for CD103(+) CCR4(+) CD8 Teff cells in the associated systemic inflammation

Author

Giuseppe Banfi, Lorenzo Drago, E. Frigerio, Francesco Sgambelluri, Gianfranco Altomare, Eva Reali, Francesca Granucci, Andrea Altomare, Marco Diani, Sgambelluri, F, Diani, M, Altomare, A, Frigerio, E, Drago, L, Granucci, F, Banfi, G, Altomare, G, Reali, E, Banfi, Giuseppe, and Reali, E.

Subjects
0301 basic medicine, CD4-Positive T-Lymphocytes, Male, C-C chemokine receptor type 6, CD8-Positive T-Lymphocytes, Systemic inflammation, Severity of Illness Index, 0302 clinical medicine, Cell Movement, T-Lymphocyte Subsets, Immunology and Allergy, Cluster Analysis, Psoriatic disease, Circulating memory T cell subset, Middle Aged, Combined Modality Therapy, medicine.anatomical_structure, Phenotype, Skin immunology/immunopathology, Cytokines, Female, medicine.symptom, Integrin alpha Chains, Adult, Receptors, CCR4, Receptors, CCR5, T cell, Immunology, Biology, CCL5, T cell trafficking, 03 medical and health sciences, Psoriasis Area and Severity Index, Antigens, CD, Psoriasis, medicine, Humans, Lymphocyte Count, Inflammation, Gene Expression Profiling, medicine.disease, 030104 developmental biology, Case-Control Studies, Memory T cell, Immunologic Memory, CD8, Biomarkers, 030215 immunology
Abstract

Recent results have identified critical components of the T cell response involved in the initiation and amplification phases of psoriasis. However the link between T cell responses arising in the skin and the systemic inflammation associated with severe psoriasis is largely unknown. We hypothesized that specific subsets of memory T cells recirculating from the skin could play a role. We therefore dissected the circulating memory T cell compartment in patients by analyzing the T-CM, T-EM and T-eff phenotype, the pattern of CCR4 and CCR5 chemokine receptor expression and the expression of the tissue homing molecule CD103. For each subset we calculated the correlation with the Psoriasis Area and Severity Index (PASI) and with the extent of systemic inflammation measured as serum level of the prototypic short pentraxin, C reactive protein (CRP). Validation was performed by comparison with gene expression data in psoriatic plaques. We found that circulating CD103(+)CCR4(+)CCR5(+) and CCR4(+)CCR6(-) CD8(+) T-eff cells, were highly correlated with CRP levels as well as with the validated index PASI, reflecting a link between skin involvement and systemic inflammation in patients with severe psoriasis. In addition we observed a contraction of circulating CCR5(+) T cells in psoriasis patients, with a highly significant inverse correlation between CCR5(+)CD4 T cells and the PASI score. Increased expression of CCR5 and CCL5 genes in psoriatic skin lesions was consistent with an accumulation of CCR5(+) cells in psoriatic plaques indicating a role for CCR5/CCL5 axis in disease pathogenesis. (C) 2016 Elsevier Ltd. All rights reserved.

Published
2015

21. Anti-adalimumab antibodies in psoriasis: lack of clinical utility and laboratory evidence

Author

Silvia Perego, Gianfranco Altomare, Marco Diani, Giovanna Lombardi, Giuseppe Banfi, Veronica Sansoni, Lombardi, G., Perego, S., Sansoni, V., Diani, M., Banfi, G., and Altomare, G.

Subjects
Adult, Male, musculoskeletal diseases, medicine.medical_specialty, Group ii, Anti-Inflammatory Agents, Dermatology, Severity of Illness Index, Antibodies, 030207 dermatology & venereal diseases, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, Psoriasis, medicine, Adalimumab, Humans, In patient, Treatment Failure, skin and connective tissue diseases, 030203 arthritis & rheumatology, High prevalence, biology, Tumor Necrosis Factor-alpha, business.industry, Research, Immunogenicity, General Medicine, Middle Aged, medicine.disease, humanities, anti-drug antibodies, Case-Control Studies, Immunology, biology.protein, Female, ELISA, Tumor necrosis factor alpha, Antibody, business, Biomarkers, medicine.drug
Abstract

Objective Adalimumab has proven effective in psoriasis; however, secondary failure may result from the drug9s immunogenicity. Prevalence data on the immunogenicity of biologicals, and of adalimumab in particular, are highly variable. We investigated the prevalence of anti-adalimumab antibodies and the association with clinical indexes and tumour necrosis factor α (TNFα) serum levels in psoriatic patients. Design Case–control, longitudinal. Setting Single centre. Participants Patient groups: I (n=20) receiving biological therapies after switching from adalimumab; II (n=30) ongoing adalimumab therapy; III (n=30) novel adalimumab therapy; IV (n=15) biological therapies other than adalimumab. Healthy subjects : (group V; n=15) never treated with immunosuppressants or biologicals. Interventions All groups were tested at enrolment. Group II was also tested at 12 months, and group III at 1, 3, and 6 months. Primary and secondary outcome measures Standard clinical evaluations (Psoriasis Area Severity Index (PASI)), blood samples and two-site ELISA-based measurement of serum adalimumab trough levels, anti-adalimumab antibodies and TNFα. Results The false-positive rate was 23% for adalimumab detection and 22% for anti-adalimumab antibodies in patients naive to adalimumab. Spurious positivity for anti-adalimumab antibodies (one-time-point positivity in group III during follow-up) accounted for 33% of the total. The prevalence of anti-drug antibodies was highest (87%) in group I patients. No correlations were found between the presence of anti-adalimumab antibodies or adalimumab levels and changes in PASI scores. Conclusions High variability of results, high prevalence of false-positives and lack of association between anti-adalimumab antibodies and TNFα level/PASI score limit this assay9s usefulness. Accurate clinical evaluation is key to early identification of treatment failures.

Published
2016
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22. Differences in Osteoimmunological Biomarkers Predictive of Psoriatic Arthritis among a Large Italian Cohort of Psoriatic Patients.

Author

Diani M, Perego S, Sansoni V, Bertino L, Gomarasca M, Faraldi M, Pigatto PDM, Damiani G, Banfi G, Altomare G, and Lombardi G

Subjects
Adult, Aged, Aged, 80 and over, Arthritis, Psoriatic immunology, Arthritis, Psoriatic metabolism, Arthritis, Psoriatic pathology, Case-Control Studies, Diagnosis, Differential, Female, Follow-Up Studies, Humans, Male, Middle Aged, Predictive Value of Tests, Psoriasis immunology, Psoriasis metabolism, Psoriasis pathology, ROC Curve, Young Adult, Arthritis, Psoriatic diagnosis, Biomarkers metabolism, Psoriasis diagnosis
Abstract

(1) Background: In literature it is reported that 20-30% of psoriatic patients evolve to psoriatic arthritis over time. Currently, no specific biochemical markers can either predict progression to psoriatic arthritis or response to therapies. This study aimed to identify osteoimmunological markers applicable to clinical practice, giving a quantitative tool for evaluating pathological status and, eventually, to provide prognostic support in diagnosis. (2) Methods: Soluble (serum) bone and cartilage markers were quantified in 50 patients with only psoriasis, 50 psoriatic patients with psoriatic arthritis, and 20 healthy controls by means of multiplex and enzyme-linked immunoassays. (3) Results: Differences in the concentrations of matrix metalloproteases (MMPs), tissue inhibitors of metalloproteinases (TIMPs), receptor activator of nuclear factor kappa-B- ligand (RANK-L), procollagen type I N propeptide (PINP), C-terminal telopeptide of type I collagen (CTx-I), dickkopf-related protein 1 (DKK1), and sclerostin (SOST) distinguished healthy controls from psoriasis and psoriatic arthritis patients. We found that MMP2, MMP12, MMP13, TIMP2, and TIMP4 distinguished psoriasis from psoriatic arthritis patients undergoing a systemic treatment, with a good diagnostic accuracy (Area under the ROC Curve (AUC) > 0.7). Then, chitinase-3-like protein 1 (CHI3L1) and MMP10 distinguished psoriasis from psoriatic arthritis not undergoing systemic therapy and, in the presence of onychopathy, MMP8 levels were higher in psoriasis than in psoriatic arthritis. However, in these latter cases, the diagnostic accuracy of the identified biomarkers was low (0.5 < AUC < 0.7). (4) Conclusions. By highlighting never exploited differences, the wide osteoimmunological biomarkers panel provides a novel clue to the development of diagnostic paths in psoriasis and psoriasis-associated arthropathic disease.

Published
2019
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23. Increased frequency of activated CD8 + T cell effectors in patients with psoriatic arthritis.

Author

Diani M, Casciano F, Marongiu L, Longhi M, Altomare A, Pigatto PD, Secchiero P, Gambari R, Banfi G, Manfredi AA, Altomare G, Granucci F, and Reali E

Subjects
Adult, Aged, Antigens, CD metabolism, Antigens, Differentiation, T-Lymphocyte metabolism, Cell Movement, Cells, Cultured, Female, Humans, Immunologic Memory, Interleukin-17 metabolism, Lectins, C-Type metabolism, Lymphocyte Activation, Male, Middle Aged, Receptors, CXCR3 metabolism, Synovial Fluid metabolism, Young Adult, Arthritis, Psoriatic immunology, CD4-Positive T-Lymphocytes immunology, CD8-Positive T-Lymphocytes immunology, Joints pathology, T-Lymphocyte Subsets immunology
Abstract

The aim of this study is to identify subsets of T cells differentially represented in the circulation of patients with psoriatic arthritis and to evaluate the possibility that they can recirculate between peripheral blood and the inflamed joints. We analyzed the phenotype and cytokine expression in circulating CD8 + and CD4 + T cells in 69 subjects: 28 with cutaneous psoriasis, 15 patients with psoriatic arthritis, and 26 healthy subjects. In the circulation, the percentage of each subset was compared among the groups and correlation was calculated with the serum concentration of C-reactive protein. To investigate the migration of T cells towards the inflamed joints, we performed a transwell migration assay towards patient serum and synovial fluid. In selected patients we analyzed in parallel T cells from peripheral blood and from synovial fluid. In the circulation, we found increased percentage of CD8 + CCR6 + T cell effectors expressing CD69 and of IL-17-producing T cells in patients with psoriatic arthritis. CD8 + effector/effector memory T cells showed increased migration towards synovial fluid. Finally, in synovial fluid we found accumulation of CXCR3 + CD8 + T cells and CD69 + cells. CD4 + T cells in the two compartments shared many similarities with CD8 + T cells. The results indicate a role for memory T cell effectors in systemic and joint manifestations of psoriatic arthritis.

Published
2019
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25. Prevalence and risk factors of actinic keratosis in patients attending Italian dermatology clinics.

Author

Fargnoli MC, Altomare G, Benati E, Borgia F, Broganelli P, Carbone A, Chimenti S, Donato S, Girolomoni G, Micali G, Moggio E, Parodi A, Piaserico S, Pistone G, Potenza C, Puviani M, Raucci M, Vaccari S, Veglio S, Zanca A, and Peris K

Subjects
Adult, Aged, Ambulatory Care Facilities statistics & numerical data, Dermatology statistics & numerical data, Female, Humans, Italy epidemiology, Keratosis, Actinic etiology, Male, Middle Aged, Prevalence, Retrospective Studies, Risk Factors, Skin Neoplasms, White People, Keratosis, Actinic epidemiology
Abstract

Actinic keratosis (AK) is a common keratinocyte intra-epidermal neoplasia. To assess AK prevalence and potential risk factors in patients attending Italian general dermatology clinics. This retrospective study was conducted on clinical data from consecutive white outpatients aged ≥30 years, attending 24 general dermatology clinics between December 2014 and February 2015. AK prevalence (entire population) and multivariate risk factor analysis (patients with current/previous AK and complete data) are presented. AK prevalence in 7,284 patients was 27.4% (95% CI: 26.4-28.4%); 34.3% in men and 20.0% in women (p<0.001). Independent AK risk factors in 4,604 patients were: age (OR: 4.8 [95% CI: 3.5-6.5] for 46-60 years, increasing with older age to OR: 41.5 [95% CI: 29.5-58.2] for >70 years), history of other non-melanoma skin cancers (OR: 2.7 [2.2-3.3]), residence in southern Italy/Sardinia (OR: 2.6 [2.1-3.0]), working outdoors >6 hours/day (OR: 1.9 [1.4-2.4]), male gender (OR: 1.7 [1.4-2.0]), facial solar lentigos (OR: 1.6 [1.4-1.9]), light hair colour (OR: 1.5 [1.2-1.8]), prolonged outdoor recreational activities (OR: 1.4 [1.2-1.7]), light eye colour (OR: 1.3 [1.1-1.6]), skin type I/II (OR: 1.3 [1.1-1.6]), and alcohol consumption (OR: 1.2 [1.0-3.3]). BMI ≥25.0 (OR: 0.6 [0.5-0.7]), regular sunscreen use (OR: 0.7 [0.6-0.8]), and a lower level of education (OR: 0.8 [0.7-1.0]) were independent protective factors. AK prevalence was high in Italian dermatology outpatients. We confirm several well-known AK risk factors and reveal possible novel risk and protective factors. Our results may inform on the design and implementation of AK screening and educational programmes.

Published
2017
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26. Blood to skin recirculation of CD4 + memory T cells associates with cutaneous and systemic manifestations of psoriatic disease.

Author

Diani M, Galasso M, Cozzi C, Sgambelluri F, Altomare A, Cigni C, Frigerio E, Drago L, Volinia S, Granucci F, Altomare G, and Reali E

Subjects
Adult, Antigens, Differentiation, T-Lymphocyte immunology, C-Reactive Protein analysis, Cytokines immunology, Female, Humans, Immunologic Memory, Male, Membrane Glycoproteins immunology, Middle Aged, Receptors, Chemokine immunology, Severity of Illness Index, Young Adult, CD4-Positive T-Lymphocytes immunology, Psoriasis blood, Psoriasis immunology, Skin immunology
Abstract

Blood to skin recirculation could play a role in the pathogenesis of psoriasis. To investigate this possibility we dissected the phenotype of circulating T cells in psoriasis patients, calculated the correlation the clinical parameters of the disease and performed a parallel bioinformatics analysis of gene expression data in psoriatic skin. We found that circulating CCR6 + CD4 + T EM and T EFF cells significantly correlated with systemic inflammation. Conversely, the percentage of CXCR3 + CD4 + T EM cells negatively correlated with the severity of the cutaneous disease. Importantly CLA + CD4 + T CM cells expressing CCR6 + or CCR4 + CXCR3 + negatively correlated with psoriasis severity suggesting recruitment to the skin compartment. This assumption was reinforced by gene expression data showing marked increase of CCR7 and CLA-encoding gene SELPLG expression in psoriatic skin and strong association of their expression. The data enlightens a role for CD4 + T cells trafficking between blood and skin in cutaneous and systemic manifestations of psoriasis., (Copyright © 2017 Elsevier Inc. All rights reserved.)

Published
2017
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28. Acquired lymphangiomas mimicking multiple hallux warts.

Author

Diani M, Turina M, Cozzi C, and Altomare G

Subjects
Biopsy, Diagnosis, Differential, Female, Humans, Lymphatic Vessels pathology, Middle Aged, Hallux pathology, Lymphangioma pathology, Skin Neoplasms pathology, Warts pathology
Abstract

Lymphangioma is an uncommon benign vascular tumour that involves lymphatic vessels. It can be acquired or, most frequently, congenital. The acquired form presents with dilated lymphatic channels due to an obstruction. These lesions have no risk of malignant transformation, but they have a high rate of recurrence whether removed. We present a case of a 52-year-old woman with acquired lymphangiomas mimicking warts. She came to our observation for some keratotic lesions on her feet. Clinically, we found three warts on the sole of her left foot, but we also noticed the presence of swelling and papillomatous wart-like papules on both halluces. The hallux papules were studied by performing an excisional biopsy and were found to be lymphangiomas.

Published
2017
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29. Methotrexate: practical use in dermatology.

Author

Diani M, Grasso V, and Altomare G

Subjects
Anti-Inflammatory Agents adverse effects, Anti-Inflammatory Agents therapeutic use, Dermatologic Agents adverse effects, Dermatology, Humans, Methotrexate adverse effects, Psoriasis drug therapy, Psoriasis pathology, Skin Diseases pathology, Dermatologic Agents therapeutic use, Methotrexate therapeutic use, Skin Diseases drug therapy
Abstract

Methotrexate (MTX) is an anti-inflammatory, anti-proliferative and immunosuppressant drug largely used worldwide with a well-known efficacy, and it is considered a safe and easy to use agent. MTX was first used in psoriasis, but it represents an effective and safe therapeutic option in a wide range of skin diseases. Despite its common employ, it is still the subject of numerous researches, with the purpose to develop new strategies to increase the manageability and evaluate the efficacy of the treatment, alone and in association with other therapies. Starting up from the official guidelines, we have reviewed the scientific literature, along with our clinical experience, in order to update the uses of MTX in dermatology.

Published
2016

30. Cyclosporine in psoriasis: comparison of a 25-year real-world Italian experience to current European guidelines.

Author

Altomare G, Ayala F, Bardazzi F, Bellia G, Chimenti S, Colombo D, Flori ML, Girolomoni G, Micali G, Parodi A, Peris K, and Vena GA

Subjects
Adult, Child, Dermatitis, Atopic drug therapy, Dermatitis, Atopic pathology, Europe, Humans, Immunosuppressive Agents therapeutic use, Italy, Practice Guidelines as Topic, Psoriasis pathology, Cyclosporine therapeutic use, Dermatologic Agents therapeutic use, Psoriasis drug therapy
Abstract

Cyclosporine (CsA) is an effective and safe therapeutic option in various dermatoses in both adults and children. Over the last 25 years, Italian dermatologists have gained relevant experience about the use of CsA in the treatment of psoriasis and atopic dermatitis, and an Italian Consensus Conference has recently provided recommendations in adult patients. A comparison between these real-world indications and current European guidelines is hereby provided.

Published
2016

32. A role for CCR5(+)CD4 T cells in cutaneous psoriasis and for CD103(+) CCR4(+) CD8 Teff cells in the associated systemic inflammation.

Author

Sgambelluri F, Diani M, Altomare A, Frigerio E, Drago L, Granucci F, Banfi G, Altomare G, and Reali E

Subjects
Adult, Antigens, CD metabolism, Biomarkers, CD4-Positive T-Lymphocytes metabolism, CD8-Positive T-Lymphocytes metabolism, Case-Control Studies, Cell Movement, Cluster Analysis, Combined Modality Therapy, Cytokines blood, Cytokines metabolism, Female, Gene Expression Profiling, Humans, Immunologic Memory, Inflammation complications, Integrin alpha Chains metabolism, Lymphocyte Count, Male, Middle Aged, Psoriasis complications, Psoriasis diagnosis, Receptors, CCR4 metabolism, Receptors, CCR5 genetics, Receptors, CCR5 metabolism, Severity of Illness Index, T-Lymphocyte Subsets metabolism, CD4-Positive T-Lymphocytes immunology, CD8-Positive T-Lymphocytes immunology, Phenotype, Psoriasis etiology, Psoriasis metabolism, T-Lymphocyte Subsets immunology
Abstract

Recent results have identified critical components of the T cell response involved in the initiation and amplification phases of psoriasis. However the link between T cell responses arising in the skin and the systemic inflammation associated with severe psoriasis is largely unknown. We hypothesized that specific subsets of memory T cells recirculating from the skin could play a role. We therefore dissected the circulating memory T cell compartment in patients by analyzing the TCM, TEM and Teff phenotype, the pattern of CCR4 and CCR5 chemokine receptor expression and the expression of the tissue homing molecule CD103. For each subset we calculated the correlation with the Psoriasis Area and Severity Index (PASI) and with the extent of systemic inflammation measured as serum level of the prototypic short pentraxin, C reactive protein (CRP). Validation was performed by comparison with gene expression data in psoriatic plaques. We found that circulating CD103(+)CCR4(+)CCR5(+) and CCR4(+)CCR6(-) CD8(+) Teff cells, were highly correlated with CRP levels as well as with the validated index PASI, reflecting a link between skin involvement and systemic inflammation in patients with severe psoriasis. In addition we observed a contraction of circulating CCR5(+) T cells in psoriasis patients, with a highly significant inverse correlation between CCR5(+)CD4 T cells and the PASI score. Increased expression of CCR5 and CCL5 genes in psoriatic skin lesions was consistent with an accumulation of CCR5(+) cells in psoriatic plaques indicating a role for CCR5/CCL5 axis in disease pathogenesis., (Copyright © 2016 Elsevier Ltd. All rights reserved.)

Published
2016
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33. Skin microbiota of first cousins affected by psoriasis and atopic dermatitis.

Author

Drago L, De Grandi R, Altomare G, Pigatto P, Rossi O, and Toscano M

Abstract

Background: Psoriasis and atopic dermatitis (AD) are chronic inflammatory skin diseases, which negatively influence the quality of life. In the last years, several evidences highlighted the pivotal role of skin bacteria in worsening the symptomatology of AD and psoriasis. In the present study we evaluated the skin microbiota composition in accurately selected subjects affected by (AD) and psoriasis., Methods: Three first cousins were chosen for the study according to strict selection of criteria. One subject was affected by moderate AD, one had psoriasis and the last one was included as healthy control. Two lesional skin samples and two non-lesional skin samples (for AD and psoriatic subjects) from an area of 2 cm(2) behind the left ear were withdrawn by mean of a curette. For the healthy control, two skin samples from an area of 2 cm(2) behind the left ear were withdrawn by mean of a curette. DNA was extracted and sequencing was completed on the Ion Torrent PGM platform. Culturing of Staphylococcus aureus from skin samples was also performed., Results: The psoriatic subject showed a decrease in Firmicutes abundance and an increase in Proteobacteria abundance. Moreover, an increase in Streptococcaceae, Rhodobacteraceae, Campylobacteraceae and Moraxellaceae has been observed in psoriatic subject, if compared with AD individual and control. Finally, AD individual showed a larger abundance of S. aureus than psoriatic and healthy subjects. Moreover, the microbiota composition of non-lesional skin samples belonging to AD and psoriatic individuals was very similar to the bacterial composition of skin sample belonging to the healthy control., Conclusion: Significant differences between the skin microbiota of psoriatic individual and healthy and AD subjects were observed.

Published
2016
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34. T Helper Cell Subsets in Clinical Manifestations of Psoriasis.

Author

Diani M, Altomare G, and Reali E

Subjects
Animals, Cell Communication, Humans, Lymphocyte Count, Psoriasis metabolism, Severity of Illness Index, T-Lymphocyte Subsets metabolism, T-Lymphocytes, Helper-Inducer metabolism, Th1 Cells immunology, Th1 Cells metabolism, Th17 Cells immunology, Th17 Cells metabolism, Phenotype, Psoriasis diagnosis, Psoriasis etiology, T-Lymphocyte Subsets immunology, T-Lymphocytes, Helper-Inducer immunology
Abstract

Psoriasis is a chronic inflammatory skin disease, which is associated with systemic inflammation and comorbidities, such as psoriatic arthritis and cardiovascular diseases. The autoimmune nature of psoriasis has been established only recently, conferring a central role to epidermal CD8 T cells recognizing self-epitopes in the initial phase of the disease. Different subsets of helper cells have also been reported as key players in the psoriasis pathogenesis. Here, we reviewed the knowledge on the role of each subset in the psoriatic cascade and in the different clinical manifestations of the disease. We will discuss the role of Th1 and Th17 cells in the initiation and in the amplification phase of cutaneous inflammation. Moreover, we will discuss the recently proposed role of tissue resident Th22 cells in disease memory in sites of recurrent psoriasis and the possible involvement of Th9 cells. Finally, we will discuss the hypothesis of a link between T helper cell subsets recirculating from the skin and the systemic manifestations of psoriasis.

Published
2016
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35. Biosimilar infliximab: an expert view.

Author

Genazzani A, Altomare G, Balato N, Cusano F, De Pità O, Loconsole F, Micali G, Piaserico S, and Girolomoni G

Subjects
Antibodies, Monoclonal chemistry, Biosimilar Pharmaceuticals chemistry, Drug Approval, Humans, Infliximab chemistry, Italy, Molecular Weight, Antibodies, Monoclonal therapeutic use, Biosimilar Pharmaceuticals therapeutic use, Infliximab therapeutic use
Abstract

CT-P13, a biosimilar of infliximab, was the first biosimilar monoclonal antibody to be approved in both the European Union and Korea. As a monoclonal antibody, CT-P13 is a large molecule with a high molecular weight, and as such it differs from other biosimilars currently in the market. The comparability exercise for CT-P13, therefore, requires special consideration, as it was the first demonstration of biosimilarity between a biosimilar monoclonal antibody and its originator. This paper summarizes current regulations on the approval of biosimilars, describes the evidence leading to the approval of CT-P13, and discusses the potential role of this molecule in the Italian scenario on the basis of the view of a group of experts.

Published
2015

36. T cell responses in psoriasis and psoriatic arthritis.

Author

Diani M, Altomare G, and Reali E

Subjects
Arthritis, Psoriatic genetics, Autoimmunity, CD8-Positive T-Lymphocytes pathology, Cytokines immunology, Humans, Inflammation genetics, Inflammation pathology, Keratinocytes pathology, Psoriasis genetics, Skin pathology, Arthritis, Psoriatic immunology, Arthritis, Psoriatic pathology, Psoriasis immunology, Psoriasis pathology
Abstract

According to the current view the histological features of psoriasis arise as a consequence of the interplay between T cells, dendritic cells and keratinocytes giving rise to a self-perpetuating loop that amplifies and sustains inflammation in lesional skin. In particular, myeloid dendritic cell secretion of IL-23 and IL-12 activates IL-17-producing T cells, Th22 and Th1 cells, leading to the production of inflammatory cytokines such as IL-17, IFN-γ, TNF and IL-22. These cytokines mediate effects on keratinocytes thus establishing the inflammatory loop. Unlike psoriasis the immunopathogenic features of psoriatic arthritis are poorly characterized and there is a gap in the knowledge of the pathogenic link between inflammatory T cell responses arising in the skin and the development of joint inflammation. Here we review the knowledge accumulated over the years from the early evidence of autoreactive CD8 T cells that was studied mainly in the years 1990s and 2000s to the recent findings of the role of Th17, Tc17 cells and γδ T cells in psoriatic disease pathogenesis. The review will also focus on common and distinguishing features of T cell responses in psoriatic plaques and in synovial fluid of patients with psoriatic arthritis. The integration of this information could help to distinguish the role played by T cells in the initiation phase of the disease from the role of T cells as downstream effectors sustaining inflammation in psoriatic plaques and potentially leading to disease manifestation in distant joints., (Copyright © 2014 Elsevier B.V. All rights reserved.)

Published
2015
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37. Differential management of mild-to-severe psoriasis with biologic drugs: An Italian Delphi consensus expert panel.

Author

Girolomoni G, Altomare G, Ayala F, Berardesca E, Calzavara Pinton P, Chimenti S, Martini P, Peserico A, Puglisi Guerra A, and Vena GA

Subjects
Consensus, Etanercept therapeutic use, Humans, Psoriasis physiopathology, Surveys and Questionnaires, Biological Products therapeutic use, Biological Therapy methods, Psoriasis drug therapy
Abstract

Background: In the management of moderate-to-severe psoriasis, increasingly complex clinical scenarios necessitate practical tools for appropriate biologic therapy selection in individual patients. An Italian Delphi consensus panel provided guidance on biologic use in selected clinical scenarios., Methods: Ten experts defined statements under consideration, which were distributed as an online survey to a dermatologist panel. Plenary discussions of contentious statements were held to achieve consensus., Results: The survey was sent to 30 clinicians. After plenary discussions, consensus was reached on all 20 statements on the following topics: special populations; infections; comorbidities; immunogenicity; extra-cutaneous involvement; pregnancy; and adherence. Three statements required further discussion in order to gain consensus: use of subcutaneous biologics in mild liver impairment (final 94% agreement), use of any biologic in discoid lupus erythematosus (final 100% disagreement), and use of etanercept in patients with history of hypersensitivity reactions to drugs and/or food (final 75% disagreement)., Conclusions: This Delphi expert consensus on the use of biologics in psoriasis provides practical recommendations for dermatologists to use when choosing an appropriate biologic in challenging but common clinical scenarios. More data are required to clarify clinical differences of biologic drugs used to treat psoriasis.

Published
2015
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38. Reply to Scalone and Cortesi: "Cost-utility analysis of biologic therapies to treat chronic plaque psoriasis in Italy: the importance of using updated and adequate social tariffs to calculate QALYs".

Author

Spandonaro F, Ayala F, Berardesca E, Chimenti S, Girolomoni G, Martini P, Peserico A, Polistena B, Guerra AP, Vena GA, Altomare G, and Pinton PC

Subjects
Female, Humans, Male, Biological Therapy economics, Psoriasis drug therapy, Psoriasis economics
Published
2015
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