963 results on '"Brick, P."'
Search Results
2. Imaging characteristics of hip joint microinstability: a case–control study of hip arthroscopy patients
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Vesey, Renuka M., MacDonald, Andrew A., Brick, Matthew J., Bacon, Catherine J., Foo, Gen Lin, Lu, Man, Lightfoot, Nicholas, Blankenbaker, Donna G., and Woodward, Rebecca M.
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- 2024
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3. (In)attention to attractive brand alternatives
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Brick, Danielle J. and Thomas, Veronica L.
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- 2024
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4. Climate change engagement of scientists
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Dablander, Fabian, Sachisthal, Maien S. M., Cologna, Viktoria, Strahm, Noel, Bosshard, Anna, Grüning, Nana-Maria, Green, Alison J. K., Brick, Cameron, Aron, Adam R., and Haslbeck, Jonas M. B.
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- 2024
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5. Childhood adversity, accelerated GrimAge, and associated health consequences
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Harvanek, Zachary M., Kudinova, Anastacia Y., Wong, Samantha A., Xu, Ke, Brick, Leslie, Daniels, Teresa E., Marsit, Carmen, Burt, Amber, Sinha, Rajita, and Tyrka, Audrey R.
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- 2024
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6. Mental health during the Covid-19 pandemic: An international comparison of gender-related home and work-related responsibilities, and social support
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Eugene, Dominique, Nöthling, Jani, Tarsitani, Lorenzo, Palantza, Christina, Papola, Davide, Barbui, Corrado, Bryant, Richard, Panter-Brick, Catherine, Hall, Brian J., Lam, Agnes Iok Fok, Huizink, Anja C., Fuhr, Daniela, Purba, Fredrick Dermawan, Mittendorfer-Rutz, Ellenor, Andriani, Dhini, van der Waerden, Judith, Acartürk, Ceren, Kurt, Gülşah, Burchert, Sebastian, Knaevelsrud, Christine, Witteveen, Anke B., Patane, Martina, Quero, Soledad, Díaz-García, Amanda, Morina, Naser, Pinucci, Irene, Sijbrandij, Marit, and Seedat, Soraya
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- 2024
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7. Institutional stickiness and Afghanistan’s unending revolution
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Basir, Tariq, Murtazashvili, Ilia, and Murtazashvili, Jennifer Brick
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- 2024
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8. Sociodemographic and clinical characteristics associated with rehabilitation services utilization in older women with early-stage breast cancer from SEER-Medicare 2009–2018
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Gorzelitz, Jessica S., Brick, Rachelle, Deng, Luqin, Mollica, Michelle, Stout, Nicole, Stoller, Stefanie, and Williams, Courtney P.
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- 2024
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9. Durability of the moderate-to-heavy-intensity transition is related to the effects of prolonged exercise on severe-intensity performance
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Hamilton, Kate, Kilding, Andrew E., Plews, Daniel J., Mildenhall, Mathew J., Waldron, Mark, Charoensap, Thanchanok, Cox, Tobias H., Brick, Matthew J., Leigh, Warren B., and Maunder, Ed
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- 2024
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10. Innovations in Surface Modification Techniques: Advancing Hydrophilic \textit{LiYF$_{4}$:Yb, Er, Tm} Upconversion Nanoparticles and Their Applications
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Esmaeili, Shahriar, Rajil, Navid, Hazrathosseini, Ayla, Neuman, Benjamin W., Alkahtani, Masfer H., Alzahrani, Yahya A., Yi, Zhenhuan, Brick, Robert W., Sokolov, Alexei V., Hemmer, Philip R., and Scully, Marlan O.
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Physics - Applied Physics ,Condensed Matter - Materials Science - Abstract
The development and application of upconversion nanoparticles (UCNPs) have garnered significant attention due to their unique optical properties and potential uses in bioimaging, drug delivery, and solar cells. However, the hydrophobic nature of UCNPs presents challenges in their synthesis and application, particularly in aqueous environments. We provide an overview of UCNPs, their synthesis challenges, and the importance of surface modification. Furthermore, we discuss the properties of \textit{LiYF_{4}:Yb, Er, Tm} UCNPs synthesized using novel 2,2-[ethylenebis(oxy)] bisacetic acid (EBAA) method and their versatile applications. Notably, the first Dynamic Light Scattering measurement on 05/22/2022 showed a size of 11.39 nm, and after 348 days on 04/05/2023, the same batch maintained a size of 13.8 nm, indicating excellent stability and no particle agglomeration over this extended period. This remarkable stability underscores the potential of UCNPs synthesized with the EBAA method for long-term applications. Finally, we compare the EBAA method with other surface modification techniques, exploring challenges and future perspectives for the use of hydrophilic UCNPs in various applications. This review aims to emphasize the significance of the EBAA method in advancing the field of upconversion nanoparticles and broadening their potential integration into diverse applications., Comment: 21 Pages, 1 table, 13 figures
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- 2023
11. Locally applied heat stress during exercise training may promote adaptations to mitochondrial enzyme activities in skeletal muscle
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Maunder, Ed, King, Andrew, Rothschild, Jeffrey A., Brick, Matthew J., Leigh, Warren B., Hedges, Christopher P., Merry, Troy L., and Kilding, Andrew E.
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- 2024
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12. Invariant Relations: A Bridge from Programs to Equations
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Ghardallou, Wided, Mohammadi, Hessamaldin, Brick, Elijah, and Mili, Ali
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Computer Science - Logic in Computer Science ,Computer Science - Discrete Mathematics ,Computer Science - Programming Languages ,Computer Science - Software Engineering - Abstract
Great advances in program analysis would be enabled if it were possible to derive the function of a program from inputs to outputs (or from initial states to final states, depending on how we model program semantics). Efforts to do so have always stalled against the difficulty to derive the function of loops; the expedient solution to capture the function of loops by unrolling them an arbitrary number of iterations is clearly inadequate. In this paper, we propose a relations-based method to derive the function of a C-like program, including programs that have loops nested to an arbitrary level. To capture the semantics of loops, we use the concept of invariant relation., Comment: 32 pages
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- 2023
13. Geoheritage Sites of the Subterranean Twin Cities
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Brick, Greg
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- 2024
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14. The International Climate Psychology Collaboration: Climate change-related data collected from 63 countries
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Kimberly C. Doell, Boryana Todorova, Madalina Vlasceanu, Joseph B. Bak Coleman, Ekaterina Pronizius, Philipp Schumann, Flavio Azevedo, Yash Patel, Michael M. Berkebile-Wineberg, Cameron Brick, Florian Lange, Samantha J. Grayson, Yifei Pei, Alek Chakroff, Karlijn L. van den Broek, Claus Lamm, Denisa Vlasceanu, Sara M. Constantino, Steve Rathje, Danielle Goldwert, Ke Fang, Salvatore Maria Aglioti, Mark Alfano, Andy J. Alvarado-Yepez, Angélica Andersen, Frederik Anseel, Matthew A. J. Apps, Chillar Asadli, Fonda Jane Awuor, Piero Basaglia, Jocelyn J. Bélanger, Sebastian Berger, Paul Bertin, Michał Białek, Olga Bialobrzeska, Michelle Blaya-Burgo, Daniëlle N. M. Bleize, Simen Bø, Lea Boecker, Paulo S. Boggio, Sylvie Borau, Björn Bos, Ayoub Bouguettaya, Markus Brauer, Tymofii Brik, Roman Briker, Tobias Brosch, Ondrej Buchel, Daniel Buonauro, Radhika Butalia, Héctor Carvacho, Sarah A. E. Chamberlain, Hang-Yee Chan, Dawn Chow, Dongil Chung, Luca Cian, Noa Cohen-Eick, Luis Sebastian Contreras-Huerta, Davide Contu, Vladimir Cristea, Jo Cutler, Silvana D’Ottone, Jonas De keersmaecker, Sarah Delcourt, Sylvain Delouvée, Kathi Diel, Benjamin D. Douglas, Moritz A. Drupp, Shreya Dubey, Jānis Ekmanis, Christian T. Elbaek, Mahmoud Elsherif, Iris M. Engelhard, Yannik A. Escher, Tom W. Etienne, Laura Farage, Ana Rita Farias, Stefan Feuerriegel, Andrej Findor, Lucia Freira, Malte Friese, Neil Philip Gains, Albina Gallyamova, Sandra J. Geiger, Oliver Genschow, Biljana Gjoneska, Theofilos Gkinopoulos, Beth Goldberg, Amit Goldenberg, Sarah Gradidge, Simone Grassini, Kurt Gray, Sonja Grelle, Siobhán M. Griffin, Lusine Grigoryan, Ani Grigoryan, Dmitry Grigoryev, June Gruber, Johnrev Guilaran, Britt Hadar, Ulf J. J. Hahnel, Eran Halperin, Annelie J. Harvey, Christian A. P. Haugestad, Aleksandra M. Herman, Hal E. Hershfield, Toshiyuki Himichi, Donald W. Hine, Wilhelm Hofmann, Lauren Howe, Enma T. Huaman-Chulluncuy, Guanxiong Huang, Tatsunori Ishii, Ayahito Ito, Fanli Jia, John T. Jost, Veljko Jovanović, Dominika Jurgiel, Ondřej Kácha, Reeta Kankaanpää, Jaroslaw Kantorowicz, Elena Kantorowicz-Reznichenko, Keren Kaplan Mintz, Ilker Kaya, Ozgur Kaya, Narine Khachatryan, Anna Klas, Colin Klein, Christian A. Klöckner, Lina Koppel, Alexandra I. Kosachenko, Emily J. Kothe, Ruth Krebs, Amy R. Krosch, Andre P. M. Krouwel, Yara Kyrychenko, Maria Lagomarsino, Julia Lee Cunningham, Jeffrey Lees, Tak Yan Leung, Neil Levy, Patricia L. Lockwood, Chiara Longoni, Alberto López Ortega, David D. Loschelder, Jackson G. Lu, Yu Luo, Joseph Luomba, Annika E. Lutz, Johann M. Majer, Ezra Markowitz, Abigail A. Marsh, Karen Louise Mascarenhas, Bwambale Mbilingi, Winfred Mbungu, Cillian McHugh, Marijn H. C. Meijers, Hugo Mercier, Fenant Laurent Mhagama, Katerina Michalaki, Nace Mikus, Sarah G. Milliron, Panagiotis Mitkidis, Fredy S. Monge-Rodríguez, Youri L. Mora, Michael J. Morais, David Moreau, Kosuke Motoki, Manuel Moyano, Mathilde Mus, Joaquin Navajas, Tam Luong Nguyen, Dung Minh Nguyen, Trieu Nguyen, Laura Niemi, Sari R. R. Nijssen, Gustav Nilsonne, Jonas P. Nitschke, Laila Nockur, Ritah Okura, Sezin Öner, Asil Ali Özdoğru, Helena Palumbo, Costas Panagopoulos, Maria Serena Panasiti, Philip Pärnamets, Mariola Paruzel-Czachura, Yuri G. Pavlov, César Payán-Gómez, Adam R. Pearson, Leonor Pereira da Costa, Hannes M. Petrowsky, Stefan Pfattheicher, Nhat Tan Pham, Vladimir Ponizovskiy, Clara Pretus, Gabriel G. Rêgo, Ritsaart Reimann, Shawn A. Rhoads, Julian Riano-Moreno, Isabell Richter, Jan Philipp Röer, Jahred Rosa-Sullivan, Robert M. Ross, Anandita Sabherwal, Toshiki Saito, Oriane Sarrasin, Nicolas Say, Katharina Schmid, Michael T. Schmitt, Philipp Schoenegger, Christin Scholz, Mariah G. Schug, Stefan Schulreich, Ganga Shreedhar, Eric Shuman, Smadar Sivan, Hallgeir Sjåstad, Meikel Soliman, Katia Soud, Tobia Spampatti, Gregg Sparkman, Ognen Spasovski, Samantha K. Stanley, Jessica A. Stern, Noel Strahm, Yasushi Suko, Sunhae Sul, Stylianos Syropoulos, Neil C. Taylor, Elisa Tedaldi, Gustav Tinghög, Luu Duc Toan Huynh, Giovanni Antonio Travaglino, Manos Tsakiris, İlayda Tüter, Michael Tyrala, Özden Melis Uluğ, Arkadiusz Urbanek, Danila Valko, Sander van der Linden, Kevin van Schie, Aart van Stekelenburg, Edmunds Vanags, Daniel Västfjäll, Stepan Vesely, Jáchym Vintr, Marek Vranka, Patrick Otuo Wanguche, Robb Willer, Adrian Dominik Wojcik, Rachel Xu, Anjali Yadav, Magdalena Zawisza, Xian Zhao, Jiaying Zhao, Dawid Żuk, and Jay J. Van Bavel
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Science - Abstract
Abstract Climate change is currently one of humanity’s greatest threats. To help scholars understand the psychology of climate change, we conducted an online quasi-experimental survey on 59,508 participants from 63 countries (collected between July 2022 and July 2023). In a between-subjects design, we tested 11 interventions designed to promote climate change mitigation across four outcomes: climate change belief, support for climate policies, willingness to share information on social media, and performance on an effortful pro-environmental behavioural task. Participants also reported their demographic information (e.g., age, gender) and several other independent variables (e.g., political orientation, perceptions about the scientific consensus). In the no-intervention control group, we also measured important additional variables, such as environmentalist identity and trust in climate science. We report the collaboration procedure, study design, raw and cleaned data, all survey materials, relevant analysis scripts, and data visualisations. This dataset can be used to further the understanding of psychological, demographic, and national-level factors related to individual-level climate action and how these differ across countries.
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- 2024
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15. Cycle route uptake and scenario estimation (CRUSE): an approach for developing strategic cycle network planning tools
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Robin Lovelace, Joey Talbot, Eugeni Vidal-Tortosa, Hussein Mahfouz, Elaine Brick, Peter Wright, Gary O’Toole, Dan Brennan, and Suzanne Meade
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Cycling ,Open source ,Road safety ,Active travel ,Transport planning ,Collaborative planning ,Transportation engineering ,TA1001-1280 ,Transportation and communications ,HE1-9990 - Abstract
Abstract This paper describes an approach for developing strategic cycle network planning tools. Based on our experience developing and deploying the Cycle Route Uptake and Scenario Estimation (CRUSE) Tool for Ireland, we outline the underlying methods, including disaggregation of origin–destination data with the open source ‘odjitter’ software, incorporation of additional trip purposes, routing, scenario generation, and development of an intuitive user interface that is tested and used by practitioners. Commissioned by the national infrastructure agency Transport Infrastructure Ireland, CRUSE provides estimates of current and potential future cycling levels under ‘snapshot’ scenarios to inform investment decisions. The publicly available results at https://cruse.bike/ enable planners, engineers, and other stakeholders to make more evidence-based decisions. CRUSE goes beyond previous work by: modeling networks at high spatial resolution; simulating multiple trip purposes (social, shopping, personal utility, recreational, and cycle touring), supplementing official origin–destination datasets on travel for work and education; and providing estimates of ‘quietness’ (a proxy for cyclist comfort and route preference) at the route segment level. Three network types—‘Fastest’, ‘Balanced’, and ‘Quietest’—help plan both arterial and residential cycle networks. Workshops with stakeholders were used to inform the development of the tool. Feedback shows that the tool has a wide range of uses and is already being used in practice to inform urban, inter-urban, and rural cycle network designs. The approach is flexible and open source, allowing the underlying ideas and code to be adapted, supporting more evidence-based and effective cycling policies and interventions internationally.
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- 2024
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16. Prioritizing Prevention: Examining Shelter Diversion as an Early Intervention Approach to Respond to Youth Homelessness
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Katrina Milaney, Amanda Noble, Alyjah Ermine Neil, Caitlin Stokvis, Robyn Feraday, Claire Feasby, Nadine Vertes, Meagan Mah, Nicole Jackson, Kat Main, Fadzai Blessing Punungwe, and Kristen Brick
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homelessness prevention ,youth ,shelter diversion ,community-based research ,mixed methods ,Urban groups. The city. Urban sociology ,HT101-395 - Abstract
There is a growing movement in Canada towards youth homelessness prevention. One such response, called shelter diversion aims to move young people into safe and supportive housing as quickly as possible. The objective of this project is to assess how, and in what ways, shelter diversion operates and whether this intervention permanently or temporarily diverts youth from homelessness. Our project is grounded in principles of community-based participatory research including community/university partnerships and an advisory committee of lived-experience experts. Our team is utilizing mixed methods to capture the outcomes of diversion programs. Data collection began in September 2022 and ended in May 2024. Quantitative and qualitative data analysis is underway. Preliminary results show differences in how diversion is defined and implemented across organizations. There are also differences in staffing models and program budgets. The findings from this study will contribute to a recommendation for a national definition and adaptable program model for shelter diversion, easily accessible to support the expansion of diversion programs into youth-serving organizations across Canada. This study is the first in Canada to examine the effectiveness of shelter diversion as an early intervention strategy to prevent youth homelessness on a national scale.
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- 2024
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17. Blood-based DNA methylation and exposure risk scores predict PTSD with high accuracy in military and civilian cohorts
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Agaz H. Wani, Seyma Katrinli, Xiang Zhao, Nikolaos P. Daskalakis, Anthony S. Zannas, Allison E. Aiello, Dewleen G. Baker, Marco P. Boks, Leslie A. Brick, Chia-Yen Chen, Shareefa Dalvie, Catherine Fortier, Elbert Geuze, Jasmeet P. Hayes, Ronald C. Kessler, Anthony P. King, Nastassja Koen, Israel Liberzon, Adriana Lori, Jurjen J. Luykx, Adam X. Maihofer, William Milberg, Mark W. Miller, Mary S. Mufford, Nicole R. Nugent, Sheila Rauch, Kerry J. Ressler, Victoria B. Risbrough, Bart P. F. Rutten, Dan J. Stein, Murray B. Stein, Robert J. Ursano, Mieke H. Verfaellie, Eric Vermetten, Christiaan H. Vinkers, Erin B. Ware, Derek E. Wildman, Erika J. Wolf, Caroline M. Nievergelt, Mark W. Logue, Alicia K. Smith, and Monica Uddin
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DNA methylation ,Machine learning ,PTSD ,Risk scores ,Internal medicine ,RC31-1245 ,Genetics ,QH426-470 - Abstract
Abstract Background Incorporating genomic data into risk prediction has become an increasingly popular approach for rapid identification of individuals most at risk for complex disorders such as PTSD. Our goal was to develop and validate Methylation Risk Scores (MRS) using machine learning to distinguish individuals who have PTSD from those who do not. Methods Elastic Net was used to develop three risk score models using a discovery dataset (n = 1226; 314 cases, 912 controls) comprised of 5 diverse cohorts with available blood-derived DNA methylation (DNAm) measured on the Illumina Epic BeadChip. The first risk score, exposure and methylation risk score (eMRS) used cumulative and childhood trauma exposure and DNAm variables; the second, methylation-only risk score (MoRS) was based solely on DNAm data; the third, methylation-only risk scores with adjusted exposure variables (MoRSAE) utilized DNAm data adjusted for the two exposure variables. The potential of these risk scores to predict future PTSD based on pre-deployment data was also assessed. External validation of risk scores was conducted in four independent cohorts. Results The eMRS model showed the highest accuracy (92%), precision (91%), recall (87%), and f1-score (89%) in classifying PTSD using 3730 features. While still highly accurate, the MoRS (accuracy = 89%) using 3728 features and MoRSAE (accuracy = 84%) using 4150 features showed a decline in classification power. eMRS significantly predicted PTSD in one of the four independent cohorts, the BEAR cohort (beta = 0.6839, p=0.006), but not in the remaining three cohorts. Pre-deployment risk scores from all models (eMRS, beta = 1.92; MoRS, beta = 1.99 and MoRSAE, beta = 1.77) displayed a significant (p
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- 2024
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18. Genome-Wide Association Study and Genomic Prediction of Fusarium Wilt Resistance in Common Bean Core Collection.
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Chiwina, Kenani, Xiong, Haizheng, Bhattarai, Gehendra, Dickson, Ryan, Phiri, Theresa, Chen, Yilin, Alatawi, Ibtisam, Dean, Derek, Joshi, Neelendra, Chen, Yuyan, Riaz, Awais, Gepts, Paul, Brick, Mark, Byrne, Patrick, Schwartz, Howard, Ogg, James, Otto, Kristin, Fall, Amy, Gilbert, Jeremy, and Shi, Ainong
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common bean ,fusarium wilt ,genome-wide association study ,genomic prediction ,Fusarium ,Genome-Wide Association Study ,Phaseolus ,Genomics ,Plant Diseases ,Disease Resistance - Abstract
The common bean (Phaseolus vulgaris L.) is a globally cultivated leguminous crop. Fusarium wilt (FW), caused by Fusarium oxysporum f. sp. phaseoli (Fop), is a significant disease leading to substantial yield loss in common beans. Disease-resistant cultivars are recommended to counteract this. The objective of this investigation was to identify single nucleotide polymorphism (SNP) markers associated with FW resistance and to pinpoint potential resistant common bean accessions within a core collection, utilizing a panel of 157 accessions through the Genome-wide association study (GWAS) approach with TASSEL 5 and GAPIT 3. Phenotypes for Fop race 1 and race 4 were matched with genotypic data from 4740 SNPs of BARCBean6K_3 Infinium Bea Chips. After ranking the 157-accession panel and revealing 21 Fusarium wilt-resistant accessions, the GWAS pinpointed 16 SNPs on chromosomes Pv04, Pv05, Pv07, Pv8, and Pv09 linked to Fop race 1 resistance, 23 SNPs on chromosomes Pv03, Pv04, Pv05, Pv07, Pv09, Pv10, and Pv11 associated with Fop race 4 resistance, and 7 SNPs on chromosomes Pv04 and Pv09 correlated with both Fop race 1 and race 4 resistances. Furthermore, within a 30 kb flanking region of these associated SNPs, a total of 17 candidate genes were identified. Some of these genes were annotated as classical disease resistance protein/enzymes, including NB-ARC domain proteins, Leucine-rich repeat protein kinase family proteins, zinc finger family proteins, P-loopcontaining nucleoside triphosphate hydrolase superfamily, etc. Genomic prediction (GP) accuracy for Fop race resistances ranged from 0.26 to 0.55. This study advanced common bean genetic enhancement through marker-assisted selection (MAS) and genomic selection (GS) strategies, paving the way for improved Fop resistance.
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- 2023
19. Survivorship concerns among individuals diagnosed with metastatic cancer: Findings from the Cancer Experience Registry
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Brick, Rachelle S., Gallicchio, Lisa, Mollica, Michelle A., Zaleta, Alexandra K., Tonorezos, Emily S., Jacobsen, Paul B., Castro, Kathleen M., and Miller, Melissa F.
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- 2024
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20. Realizing the full potential of behavioural science for climate change mitigation
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Nielsen, Kristian S., Cologna, Viktoria, Bauer, Jan M., Berger, Sebastian, Brick, Cameron, Dietz, Thomas, Hahnel, Ulf J. J., Henn, Laura, Lange, Florian, Stern, Paul C., and Wolske, Kimberly S.
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- 2024
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21. Father Involvement and Child Development: A Prospective Study of Syrian Refugee Families
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Hadfield, Kristin, Al-Soleiti, Majd, Dajani, Rana, Mareschal, Isabelle, and Panter-Brick, Catherine
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- 2024
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22. Cohesive Models for Anti-Plane Mode Fracture in Dissimilar Structures: Effect of Small/Large Scale Yielding Conditions on Computed Fracture Load
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Brick Chaouche, Amine
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- 2024
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23. Sample Designs and Estimators for Multimode Surveys with Face-to-Face Data Collection
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Brick, J. Michael and DeMatteis, Jill M.
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Statistics - Methodology - Abstract
Survey researchers are increasingly turning to multimode data collection to deal with declines in survey response rates and increasing costs. An efficient approach offers the less costly modes (e.g., web) followed with a more expensive mode for a subsample of the units (e.g., households) within each primary sampling unit (PSU). We present two alternatives to this traditional design. One alternative subsamples PSUs rather than units to constrain costs. The second is a hybrid design that includes a clustered (two-stage) sample and an independent, unclustered sample. Using a simulation, we demonstrate the hybrid design has considerable advantages., Comment: 60 pages, 5 exhibits, 17 figures, 1 table
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- 2023
24. Ecological momentary assessment and cue-elicited drug craving as primary endpoints: study protocol for a randomized, double-blind, placebo-controlled clinical trial testing the efficacy of a GLP-1 receptor agonist in opioid use disorder
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Christopher S. Freet, Brianna Evans, Timothy R. Brick, Erin Deneke, Emily J. Wasserman, Sarah M. Ballard, Dean M. Stankoski, Lan Kong, Nazia Raja-Khan, Jennifer E. Nyland, Amy C. Arnold, Venkatesh Basappa Krishnamurthy, Julio Fernandez-Mendoza, H. Harrington Cleveland, Adam D. Scioli, Amanda Molchanow, Amy E. Messner, Hasan Ayaz, Patricia S. Grigson, and Scott C. Bunce
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Glucagon-like peptide 1 receptor agonist ,GLP-1RA ,Craving ,Substance use disorder ,Liraglutide ,Functional near infrared spectroscopy ,Medicine (General) ,R5-920 ,Social pathology. Social and public welfare. Criminology ,HV1-9960 - Abstract
Abstract Background Despite continuing advancements in treatments for opioid use disorder (OUD), continued high rates of relapse indicate the need for more effective approaches, including novel pharmacological interventions. Glucagon-like peptide 1 receptor agonists (GLP-1RA) provide a promising avenue as a non-opioid medication for the treatment of OUD. Whereas GLP-1RAs have shown promise as a treatment for alcohol and nicotine use disorders, to date, no controlled clinical trials have been conducted to determine if a GLP-1RA can reduce craving in individuals with OUD. The purpose of the current protocol was to evaluate the potential for a GLP-1RA, liraglutide, to safely and effectively reduce craving in an OUD population in residential treatment. Method This preliminary study was a randomized, double-blinded, placebo-controlled clinical trial designed to test the safety and efficacy of the GLP-1RA, liraglutide, in 40 participants in residential treatment for OUD. Along with taking a range of safety measures, efficacy for cue-induced craving was evaluated prior to (Day 1) and following (Day 19) treatment using a Visual Analogue Scale (VAS) in response to a cue reactivity task during functional near-infrared spectroscopy (fNIRS) and for craving. Efficacy of treatment for ambient craving was assessed using Ecological Momentary Assessment (EMA) prior to (Study Day 1), across (Study Days 2–19), and following (Study Days 20–21) residential treatment. Discussion This manuscript describes a protocol to collect clinical data on the safety and efficacy of a GLP-1RA, liraglutide, during residential treatment of persons with OUD, laying the groundwork for further evaluation in a larger, outpatient OUD population. Improved understanding of innovative, non-opioid based treatments for OUD will have the potential to inform community-based interventions and health policy, assist physicians and health care professionals in the treatment of persons with OUD, and to support individuals with OUD in their effort to live a healthy life. Trial registration: ClinicalTrials.gov: NCT04199728. Registered 16 December 2019, https://clinicaltrials.gov/study/NCT04199728?term=NCT04199728 . Protocol Version 10 May 2023
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- 2024
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25. Rates of bronchopulmonary dysplasia in very low birth weight neonates: a systematic review and meta-analysis
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Alvaro Moreira, Michelle Noronha, Jooby Joy, Noah Bierwirth, Aina Tarriela, Aliha Naqvi, Sarah Zoretic, Maxwell Jones, Ali Marotta, Taylor Valadie, Jonathan Brick, Caitlyn Winter, Melissa Porter, Isabelle Decker, Matteo Bruschettini, and Sunil K. Ahuja
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Bronchopulmonary dysplasia ,Chronic lung disease ,Rates ,Prevalence ,Meta-analysis ,Diseases of the respiratory system ,RC705-779 - Abstract
Abstract Importance Large-scale estimates of bronchopulmonary dysplasia (BPD) are warranted for adequate prevention and treatment. However, systematic approaches to ascertain rates of BPD are lacking. Objective To conduct a systematic review and meta-analysis to assess the prevalence of BPD in very low birth weight (≤ 1,500 g) or very low gestational age (
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- 2024
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26. The Europa Thermal Emission Imaging System (E-THEMIS) Investigation for the Europa Clipper Mission
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Christensen, Philip R., Spencer, John R., Mehall, Greg L., Patel, Mehul, Anwar, Saadat, Brick, Matthew, Bowles, Heather, Farkas, Zoltan, Fisher, Tara, Gjellum, David, Holmes, Andrew, Kubik, Ian, Larson, Melora, Levy, Alan, Madril, Edgar, Masini, Paolo, McEwen, Thomas, Miner, Mark, Nickles, Neal, O’Donnell, William, Ortiz, Carlos, Osterman, David, Pelham, Daniel, Rudeen, Andrew, Saunders, Tyler, Woodward, Robert, Abramov, Oleg, Hayne, Paul O., Howett, Carly J. A., Mellon, Michael T., Nimmo, Francis, Piqueux, Sylvain, and Rathbun, Julie A.
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- 2024
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27. Syrian refugee young adults as community mental health workers implementing problem management plus: Protocol for a pilot randomized controlled trial to measure the mechanisms of effect on their own wellbeing, stress and coping
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Rima Nakkash, Lilian Ghandour, Grant Brown, Catherine Panter-Brick, Hailey Bomar, Malak Tleis, Hanan Al Masri, Marwa Fares, Fadi Al Halabi, Yamen Najjar, Bayan Louis, Maha Hodroj, Yara Chamoun, Myriam Zarzour, and Rima A. Afifi
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Refugee ,Bayesian hierarchical model ,Community health worker ,Young adult ,Medicine (General) ,R5-920 - Abstract
This pilot randomized controlled trial protocol aims to (1) assess the impact on the wellbeing of Syrian refugee young adults (18–24 years) of being a community mental health worker (CMHW) implementing WHO's evidence-based psychosocial intervention - Problem Management Plus (PM+) - with adults in their community, and (2) identify the mechanisms associated with the outcomes of enhanced wellbeing and coping, and reduced stress among these CMHWs. Over 108 million people have been forcibly displaced as of the end of 2022. Mental health consequences of these displacements are significant, yet human resources for health are not sufficient to meet the needs. A large proportion of refugee populations are youth and young adults (YA). Evidence indicates their engagement in supporting their communities leads to their own enhanced wellbeing and that of their community. This trial trains Syrian refugees to serve their communities as CMHW (n=19) or tutors (n=19) and compare wellbeing, stress and coping outcomes between these two groups and a control group (n = 40). We will also assess 7 mechanisms as potential pathways for the interventions to influence outcomes. Surveys will assess outcomes and mechanisms, hair samples will measure stress cortisol. The primary analysis will use a Bayesian Hierarchical Model approach to model the trajectories of the mechanisms and primary study endpoints over time for individuals in each of the arms. Our results will elucidate critical mechanisms in which engagement of young adults to support their community enhances their own wellbeing. Trial registration: National Institutes of Mental Health, NCT05265611, Registered prospectively in 2021. Lebanon clinical trials registry #: LBCTR2023015206, Registered in 2023.
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- 2024
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28. Recognizing Handwriting Styles in a Historical Scanned Document Using Unsupervised Fuzzy Clustering
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Majumdar, Sriparna and Brick, Aaron
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Computer Science - Computer Vision and Pattern Recognition - Abstract
The forensic attribution of the handwriting in a digitized document to multiple scribes is a challenging problem of high dimensionality. Unique handwriting styles may be dissimilar in a blend of several factors including character size, stroke width, loops, ductus, slant angles, and cursive ligatures. Previous work on labeled data with Hidden Markov models, support vector machines, and semi-supervised recurrent neural networks have provided moderate to high success. In this study, we successfully detect hand shifts in a historical manuscript through fuzzy soft clustering in combination with linear principal component analysis. This advance demonstrates the successful deployment of unsupervised methods for writer attribution of historical documents and forensic document analysis., Comment: 26 pages in total, 5 figures and 2 tables
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- 2022
29. On the persistent rumors of the programmer’s imminent demise
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Mohammadi, Hessam, Ghardallou, Wided, Brick, Elijah, and Mili, Ali
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- 2023
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30. The influence of telehealth-based cancer rehabilitation interventions on disability: a systematic review
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Brick, Rachelle, Padgett, Lynne, Jones, Jennifer, Wood, Kelley Covington, Pergolotti, Mackenzi, Marshall, Timothy F., Campbell, Grace, Eilers, Rachel, Keshavarzi, Sareh, Flores, Ann Marie, Silver, Julie K., Virani, Aneesha, Livinski, Alicia A., Ahmed, Mohammed Faizan, Kendig, Tiffany, Khalid, Bismah, Barnett, Jeremy, Borhani, Anita, Bernard, Graysen, and Lyons, Kathleen Doyle
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- 2023
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31. Dynamic SARS-CoV-2 surveillance model combining seroprevalence and wastewater concentrations for post-vaccine disease burden estimates
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Rochelle H. Holm, Grzegorz A. Rempala, Boseung Choi, J. Michael Brick, Alok R. Amraotkar, Rachel J. Keith, Eric C. Rouchka, Julia H. Chariker, Kenneth E. Palmer, Ted Smith, and Aruni Bhatnagar
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Medicine - Abstract
Abstract Background Despite wide scale assessments, it remains unclear how large-scale severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination affected the wastewater concentration of the virus or the overall disease burden as measured by hospitalization rates. Methods We used weekly SARS-CoV-2 wastewater concentration with a stratified random sampling of seroprevalence, and linked vaccination and hospitalization data, from April 2021–August 2021 in Jefferson County, Kentucky (USA). Our susceptible ( $$S$$ S ), vaccinated ( $$V$$ V ), variant-specific infected ( $${I}_{1}$$ I 1 and $${I}_{2}$$ I 2 ), recovered ( $$R$$ R ), and seropositive ( $$T$$ T ) model ( $${SV}{I}_{2}{RT}$$ S V I 2 R T ) tracked prevalence longitudinally. This was related to wastewater concentration. Results Here we show the 64% county vaccination rate translate into about a 61% decrease in SARS-CoV-2 incidence. The estimated effect of SARS-CoV-2 Delta variant emergence is a 24-fold increase of infection counts, which correspond to an over 9-fold increase in wastewater concentration. Hospitalization burden and wastewater concentration have the strongest correlation (r = 0.95) at 1 week lag. Conclusions Our study underscores the importance of continuing environmental surveillance post-vaccine and provides a proof-of-concept for environmental epidemiology monitoring of infectious disease for future pandemic preparedness.
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- 2024
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32. Financial toxicity among people with metastatic cancer: findings from the Cancer Experience Registry
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Mollica, Michelle A., Zaleta, Alexandra K., Gallicchio, Lisa, Brick, Rachelle, Jacobsen, Paul B., Tonorezos, Emily, Castro, Kathleen M., and Miller, Melissa F.
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- 2024
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33. Implementation and outcomes of home-based treatments for adolescents with anorexia nervosa: Study protocol for a pilot effectiveness-implementation trial.
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Goldschmidt, Andrea, Tortolani, Christina, Egbert, Amy, Brick, Leslie, Elwy, A, Donaldson, Deidre, and Le Grange, Daniel
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adaptation ,adolescent ,anorexia nervosa ,eating disorder ,effectiveness ,family-based treatment ,home-based treatment ,implementation ,mechanisms ,restrictive eating ,Adolescent ,Humans ,Anorexia Nervosa ,Family Therapy ,Treatment Outcome ,Randomized Controlled Trials as Topic ,Home Care Services - Abstract
OBJECTIVE: Although family-based treatment (FBT) is considered a first-line treatment for adolescent anorexia nervosa (AN), it is underutilized in community settings and is unavailable to many families for a multitude of practical reasons (e.g., costs of treatment, transportation constraints). Adapting FBT interventions for delivery in home-based and community-based settings may reduce pragmatic barriers to treatment uptake and engagement. METHODS: This pilot effectiveness-implementation trial will assess outcomes, implementation, and mechanisms of FBT adapted for the home setting (FBT-HB), delivered in the context of community-based behavioral health agencies. Adolescents with AN-spectrum disorders (n = 50) and their caregivers will be randomly assigned to either FBT-HB or home-based treatment as usual (TAU; integrated family therapy approach). Caregivers and adolescents will provide data on weight, eating, and putative treatment mechanisms, including caregiver self-efficacy and adolescent eating-related and weight-related distress. Implementation constructs of feasibility, acceptability, and appropriateness will be measured among providers and participating families. HYPOTHESES: We expect that FBT-HB will be feasible, acceptable, and appropriate, and will outperform TAU in terms of improvements in adolescent weight and eating-related psychopathology. We further expect that caregiver self-efficacy and adolescent eating-related and weight-related distress, but not general distress, will show greater improvements in FBT-HB relative to TAU and will be associated with better adolescent weight and eating outcomes in FBT-HB. POTENTIAL IMPLICATIONS: The proposed study has clear potential to advance scientific and clinical understanding of the real-world effectiveness of FBT for AN, including whether adapting it for the home setting improves its accessibility and effects on treatment outcome.
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- 2022
34. Triangulating on Developmental Models with a Combination of Experimental and Nonexperimental Estimates
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Wan, Sirui, Brick, Timothy R., Alvarez-Vargas, Daniela, and Bailey, Drew H.
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Plausible competing developmental models show similar or identical structural equation modeling model fit indices, despite making very different causal predictions. One way to help address this problem is incorporating outside information into selecting among models. This study attempted to select among developmental models of children's early mathematical skills by incorporating information about the extent to which models forecast the longitudinal pattern of causal impacts of early math interventions. We tested for the usefulness and validity of the approach by applying it to data from three randomized controlled trials of early math interventions with longitudinal follow-up assessments in the United States (Ns = 1,375, 591, 744; baseline age 4.3, 6.5, 4.4; 17%-69% Black). We found that, across data sets, (a) some models consistently outperformed other models at forecasting later experimental impacts, (b) traditional statistical fit indices were not strongly related to causal fit as indexed by models' accuracy at forecasting later experimental impacts, and (c) models showed consistent patterns of similarity and discrepancy between statistical fit and models' effectiveness at forecasting experimental impacts. We highlight the importance of triangulation and call for more comparisons of experimental and nonexperimental estimates for choosing among developmental models.
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- 2023
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35. Volunteer programs, empowerment, and life satisfaction in Jordan: mapping local knowledge and systems change to inform public policy and science diplomacy
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Catherine Panter-Brick, Lina Qtaishat, Jannik Joseph Eggerman, Honey Thomas, Praveen Kumar, and Rana Dajani
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empowerment ,cognitive mapping ,life satisfaction ,policy ,refugee ,participatory research ,Sociology (General) ,HM401-1281 - Abstract
IntroductionVolunteering in the community is thought to provide unique benefits to people who experience limited engagement in society. In the global South, volunteer programs are often framed as empowering women and benefiting the poor, without empirical evidence or systematic investigation of what this means from a local perspective. For this reason, it is critical to represent stakeholder knowledge, understand how change happens systemically, and reduce cultural bias in scientific inquiry and public policy. As such, efforts to respect diverse narratives and problem-solving approaches are key to science diplomacy – they help us understand cultural relevance, program efficacy, and for whom a program is considered transformative.Methods and resultsThis study shows how Syrian refugee and Jordanian women, living in resource-poor families, articulated (i) concepts of empowerment and life satisfaction and (ii) the benefits of engaging in community-based volunteering programs. Through engaging in a participatory methodology known as Fuzzy Cognitive Mapping, women generated visual representations of these constructs and cause-and-effect reasoning. They identified several dimensions of empowerment (e.g., cultural, financial, and psychological empowerment) and several meanings of life satisfaction (e.g. adaptation, acceptance, and contentment). They also mapped connections between variables, identifying those that might catalyze change. We were specifically interested in evaluating understandings of We Love Reading, a program that trains volunteers to become changemakers in their local community. In simulations, we modelled how employment, education, money, and volunteering would drive system change, with notable results on cultural empowerment.DiscussionThrough visual maps and scenarios of change, the study demonstrates a participatory approach to localizing knowledge and evaluating programs. This is key to improving scientific enquiry and public policy.
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- 2024
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36. Recursos educacionais abertos: gênero ou hipergênero?
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Cristiane Dall Cortivo Lebler, Elizandro Maurício Brick, and Marcelo Gules Borges
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leitura ,recursos educacionais abertos ,gêneros digitais ,hipergênero ,mídia/suporte ,Language and Literature ,Philology. Linguistics ,P1-1091 - Abstract
A educação digital tem se feito presente de forma cada vez mais diversa e consistente, desde o ensino formal até a produção de conteúdos educacionais em redes sociais. Nessas práticas, ganham destaque materiais de ensino-aprendizagem, dentre os quais destacamos os recursos educacionais digitais – ou recursos educacionais abertos (REAs). Por outro lado, a discussão acerca dos gêneros do discurso tem ganhado cada vez mais relevância e experimentado novos desdobramentos. Assim, considerando a importância que os REAs têm contemporaneamente na educação e a sua complexidade textual e discursiva, este trabalho tem como objetivo geral discutir a sua caracterização no quadro dos gêneros do discurso, mais especificamente sua constituição como gênero ou como hipergênero. Para isso, são mobilizados conceitos teóricos acerca do campo da educação e tecnologia, a exemplo de Castro Filho et al (2008), Santos (2013) Santana, Rossini e Pretto (2012), e dos estudos do texto e do discurso, como Marcuschi (2008), Távora (2008), Bonini (2011) e Bakhtin (2011). Os exemplares usados para análise são REAs produzidos no âmbito do Projeto EPTrilhas, desenvolvido pela Universidade Federal de Santa Catarina em parceria com a Secretaria de Educação Profissional e Tecnológica (SETEC) do Ministério da Educação. Essa análise evidenciou, pelas características do gênero, mídia e suporte, que os REAs multimodais em suporte virtual possuem características que os identificam como hipergêneros.
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- 2024
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37. Descriptive Characteristics and Outcomes of Patients Undergoing Revision Anterior Cruciate Ligament Reconstruction With and Without Tunnel Bone Grafting
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Group, MARS, DeFroda, Steven F, Owens, Brett D, Wright, Rick W, Huston, Laura J, Pennings, Jacquelyn S, Haas, Amanda K, Allen, Christina R, Cooper, Daniel E, DeBerardino, Thomas M, Dunn, Warren R, Lantz, Brett Brick A, Spindler, Kurt P, Stuart, Michael J, Albright, John P, Amendola, Annunziato, Annunziata, Christopher C, Arciero, Robert A, Bach, Bernard R, Baker, Champ L, Bartolozzi, Arthur R, Baumgarten, Keith M, Bechler, Jeffery R, Berg, Jeffrey H, Bernas, Geoffrey A, Brockmeier, Stephen F, Brophy, Robert H, Bush-Joseph, Charles A, Butler, J Brad, Carey, James L, Carpenter, James E, Cole, Brian J, Cooper, Jonathan M, Cox, Charles L, Creighton, R Alexander, David, Tal S, Flanigan, David C, Frederick, Robert W, Ganley, Theodore J, Garofoli, Elizabeth A, Gatt, Charles J, Gecha, Steven R, Giffin, James Robert, Hame, Sharon L, Hannafin, Jo A, Harner, Christopher D, Harris, Norman Lindsay, Hechtman, Keith S, Hershman, Elliott B, Hoellrich, Rudolf G, Johnson, David C, Johnson, Timothy S, Jones, Morgan H, Kaeding, Christopher C, Kamath, Ganesh V, Klootwyk, Thomas E, Levy, Bruce A, Benjamin, C, Maiers, G Peter, Marx, Robert G, Matava, Matthew J, Mathien, Gregory M, McAllister, David R, McCarty, Eric C, McCormack, Robert G, Miller, Bruce S, Nissen, Carl W, O’Neill, Daniel F, Parker, Richard D, Purnell, Mark L, Ramappa, Arun J, Rauh, Michael A, Rettig, Arthur C, Sekiya, Jon K, Shea, Kevin G, Sherman, Orrin H, Slauterbeck, James R, Smith, Matthew V, Spang, Jeffrey T, Svoboda, Steven J, Taft, Timothy N, Tenuta, Joachim J, Tingstad, Edwin M, Vidal, Armando F, Viskontas, Darius G, White, Richard A, Williams, James S, Wolcott, Michelle L, Wolf, Brian R, and York, James J
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Transplantation ,Clinical Research ,Musculoskeletal ,Anterior Cruciate Ligament Injuries ,Anterior Cruciate Ligament Reconstruction ,Cohort Studies ,Humans ,Osteoarthritis ,Quality of Life ,Reoperation ,bone graft ,outcomes ,revision anterior cruciate ligament reconstruction ,tunnel lysis ,MARS Group ,Biomedical Engineering ,Mechanical Engineering ,Human Movement and Sports Sciences ,Orthopedics - Abstract
BackgroundLytic or malpositioned tunnels may require bone grafting during revision anterior cruciate ligament reconstruction (rACLR) surgery. Patient characteristics and effects of grafting on outcomes after rACLR are not well described.PurposeTo describe preoperative characteristics, intraoperative findings, and 2-year outcomes for patients with rACLR undergoing bone grafting procedures compared with patients with rACLR without grafting.Study designCohort study; Level of evidence, 3.MethodsA total of 1234 patients who underwent rACLR were prospectively enrolled between 2006 and 2011. Baseline revision and 2-year characteristics, surgical technique, pathology, treatment, and patient-reported outcome instruments (International Knee Documentation Committee [IKDC], Knee injury and Osteoarthritis Outcome Score [KOOS], Western Ontario and McMaster Universities Osteoarthritis Index, and Marx Activity Rating Scale [Marx]) were collected, as well as subsequent surgery information, if applicable. The chi-square and analysis of variance tests were used to compare group characteristics.ResultsA total of 159 patients (13%) underwent tunnel grafting-64 (5%) patients underwent 1-stage and 95 (8%) underwent 2-stage grafting. Grafting was isolated to the femur in 31 (2.5%) patients, the tibia in 40 (3%) patients, and combined in 88 patients (7%). Baseline KOOS Quality of Life (QoL) and Marx activity scores were significantly lower in the 2-stage group compared with the no bone grafting group (P≤ .001). Patients who required 2-stage grafting had more previous ACLRs (P < .001) and were less likely to have received a bone-patellar tendon-bone or a soft tissue autograft at primary ACLR procedure (P≤ .021) compared with the no bone grafting group. For current rACLR, patients undergoing either 1-stage or 2-stage bone grafting were more likely to receive a bone-patellar tendon-bone allograft (P≤ .008) and less likely to receive a soft tissue autograft (P≤ .003) compared with the no bone grafting group. At 2-year follow-up of 1052 (85%) patients, we found inferior outcomes in the 2-stage bone grafting group (IKDC score = 68; KOOS QoL score = 44; KOOS Sport/Recreation score = 65; and Marx activity score = 3) compared with the no bone grafting group (IKDC score = 77; KOOS QoL score = 63; KOOS Sport/Recreation score = 75; and Marx activity score = 7) (P≤ .01). The 1-stage bone graft group did not significantly differ compared with the no bone grafting group.ConclusionTunnel bone grafting was performed in 13% of our rACLR cohort, with 8% undergoing 2-stage surgery. Patients treated with 2-stage grafting had inferior baseline and 2-year patient-reported outcomes and activity levels compared with patients not undergoing bone grafting. Patients treated with 1-stage grafting had similar baseline and 2-year patient-reported outcomes and activity levels compared with patients not undergoing bone grafting.
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- 2022
38. Supporting Success: The Higher Education in Prison Key Performance Indicator Framework
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Institute for Higher Education Policy (IHEP), Brick, Michael Scott, and Ajinkya, Julie
- Abstract
Recognizing the transformative potential of higher education for people involved in the justice system, the Institute for Higher Education Policy (IHEP) with an advisory council of experienced higher education in prison (HEP) practitioners, data experts, and dedicated advocates, with input from students who are incarcerated, developed guidance to properly identify and benchmark quality higher education in prison (HEP) programs nationwide. This report outlines a comprehensive set of key performance indicators (KPI) that will help HEP programs generate long-needed data to inform program quality, develop robust standards of practice, and ensure quality outcomes for students. The KPI framework outlines metrics in four assessment categories: student success outcomes; academic quality; civic engagement; and soft skills, the non-technical and interpersonal proficiencies identified by employers as essential for success in today's workplace. In addition to listing and defining the indicators in the four assessment categories, the report includes recommendations for practitioners, correctional administrators, and state and federal policymakers.
- Published
- 2020
39. Repurposing Virtual Reality Assets: From Health Sciences to Italian Language Learning
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Plutino, Alessia, Cervi-Wilson, Tiziana, and Brick, Billy
- Abstract
This paper reports on the rationale for the implementation of a pilot project using a scenario-based Virtual Reality (VR) resource, originally developed by Health Sciences at Coventry University and now being repurposed for Italian language learning as a collaborative project with Modern Languages and Linguistics at the University of Southampton. The original aim of the resource was to prepare health care students for home visits by allowing them to experience a semi-linear conversation with a virtual Non-player Character (NPC). The authors will discuss how they are planning to repurpose the resource for Italian language learning and teaching and will analyse the potential pedagogical uses within the modern language curriculum, including emotional language, employability skills, and the year abroad. [For the complete volume, "Innovative Language Teaching and Learning at University: Treasuring Languages," see ED604577.]
- Published
- 2020
40. A Meta-Analysis of Selected Studies on the Effectiveness of Gamification Method for Children
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Fadhli, Muhibuddin, Brick, Billy, Setyosari, Punaji, Ulfa, Saida, and Kuswandi, Dedi
- Abstract
A Meta-analysis of selected studies on the effectiveness of gamification method for children. Multiple gamification methods are used to motivate students to improve their learning outcomes. Yet, this method is still very rarely used in learning for children aged 6-10 years. This systematic review and meta-analysis aim to objectively determine the effectiveness of gamification method in increasing knowledge, skills and attitudes of children aged 6-10 years.The data were obtained from the ERIC, Emerald and Elsevier databases published between 2014-2018 using the keywords of "gamification on education", "gamification methods", and "children". In the chosen systematical analysis, 6 studies were then reviewed using a meta-analysis. The effect summary showed a value of 1.01 with confident interval of 0.98-1.05, which indicates that gamification method is statistically effective in improving students' knowledge, skills, and children's attitudes. The Z test with a value of 0.68 and a significance level of 5% also showed a significant effect of this method calculated by random-effect models.
- Published
- 2020
41. Quantum Optical Immunoassay: Upconversion Nanoparticle-based Neutralizing Assay for COVID-19
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Rajil, Navid, Esmaeili, Shahriar, Neuman, Benjamin W., Nessler, Reed, Wu, Hung-Jen, Yi, Zhenhuan, Brick, Robert W., Sokolov, Alexei V., Hemmer, Philip R., and Scully, Marlan O.
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Physics - Biological Physics ,Quantitative Biology - Biomolecules ,Quantitative Biology - Quantitative Methods - Abstract
In a viral pandemic, a few important tests are required for successful containment of the virus and reduction in severity of the infection. Among those tests, a test for the neutralizing ability of an antibody is crucial for assessment of population immunity gained through vaccination, and to test therapeutic value of antibodies made to counter the infections. Here, we report a sensitive technique to detect the relative neutralizing strength of various antibodies against the SARS-CoV-2 virus. We used bright, photostable, background-free, fluorescent upconversion nanoparticles conjugated with SARS-CoV-2 receptor binding domain as a phantom virion. A glass bottom plate coated with angiotensin-converting enzyme 2 (ACE-2) protein imitates the target cells. When no neutralizing IgG antibody was present in the sample, the particles would bind to the ACE-2 with high affinity. In contrast, a neutralizing antibody can prevent particle attachment to the ACE-2-coated substrate. A prototype system consisting of a custom-made confocal microscope was used to quantify particle attachment to the substrate. The sensitivity of this assay can reach 4.0 ng/ml and the dynamic range is from 1.0 ng/ml to 3.2 {\mu}g/ml. This is to be compared to 19 ng/ml sensitivity of commercially available kits.
- Published
- 2021
42. Large-Scale Disruptive Activism Strengthened Environmental Attitudes in the United Kingdom
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Ben Kenward and Cameron Brick
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environmental activism ,civil disobedience ,public opinion ,extinction rebellion ,longitudinal and experimental methods ,Environmental sciences ,GE1-350 ,Psychology ,BF1-990 - Abstract
The 2019 London Extinction Rebellion was the first attempt by environmental protesters to create prolonged large-scale disruption in a Western capital city. The effects on public opinion were difficult to predict because protests seen as extreme can reduce support, but protests seen as justified can increase support. We studied longitudinal opinion changes in a nationally representative sample (n = 832) before, during, and after the rebellion, in conjunction with experimental analysis of the causal effects of media reports (n = 1441). The rebellion was longitudinally associated with national increases in environmental concern, and activist media increased dissatisfaction with current government action. Reports from different media sources caused activism intentions and support to move in different directions, contributing to longitudinally increased polarisation in attitudes to activism. The rebellion had minimal effects on belief in whether ordinary people can produce relevant change (based on collective efficacy and support for a Citizens’ Assembly). The rebellion thus apparently succeeded in strengthening general environmental attitudes without polarising them, and probably somewhat grew the pool of engaged activists, but did not lead to major growth in collective mobilisation or improved environmental policy.
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- 2024
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43. Clinical utility of C‐reactive protein‐to‐albumin ratio in the management of patients with inflammatory bowel disease
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Anke L Nguyen, Claudia Brick, David Liu, David J Gibson, Peter R Gibson, and Miles P Sparrow
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albumin ,C‐reactive protein ,inflammatory bowel disease ,Diseases of the digestive system. Gastroenterology ,RC799-869 - Abstract
Abstract Background and Aim C‐reactive protein (CRP)‐to‐albumin ratio (CAR) is a novel score with prognostic value in inflammatory conditions. This study assessed the performance of CAR as an objective marker of disease activity and prediction of subtherapeutic infliximab trough levels in patients with inflammatory bowel disease (IBD). Methods A retrospective study was conducted on three different patient cohorts with IBD: patients who had (i) fecal calprotectin (FC) measurements; (ii) Mayo Endoscopic Scores; and (iii) infliximab trough levels available. The relative performances of CAR, albumin, and CRP were compared in predicting disease activity (based on FC or Mayo Endoscopic Score) and infliximab trough levels. Results In both the FC (n = 289) and endoscopy (n = 65) cohorts, albumin and CAR correlated with objective disease activity. CAR (area under the curve [AUC] 0.70) was only marginally better at detecting active disease, measured by FC, compared to CRP (AUC 0.68). A CAR >0.15 was able to detect Mayo 3 disease (AUC 0.83, sensitivity 81%, specificity 89%). Albumin (r = 0.38) and CAR (r = −0.42) correlated with infliximab trough levels (n = 204). The optimal CAR for detecting subtherapeutic infliximab trough levels was >0.08 (AUC 0.70, sensitivity 66%, specificity 64%). Both albumin and CAR were independent predictors of subtherapeutic infliximab trough levels but correlated poorly with infliximab trough levels longitudinally in the same patient. Conclusion CAR was only a modest discriminator of subtherapeutic infliximab levels and offers little more than CRP in detecting active disease. CAR has potential to detect severe Mayo 3 disease and could be calculated in patients admitted with suspected acute severe ulcerative colitis.
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- 2024
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44. The Precision Interventions for Severe and/or Exacerbation-Prone (PrecISE) Asthma Network: An overview of Network organization, procedures, and interventions
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Georas, Steve N, Wright, Rosalind J, Ivanova, Anastasia, Israel, Elliot, LaVange, Lisa M, Akuthota, Praveen, Carr, Tara F, Denlinger, Loren C, Fajt, Merritt L, Kumar, Rajesh, O’Neal, Wanda K, Phipatanakul, Wanda, Szefler, Stanley J, Aronica, Mark A, Bacharier, Leonard B, Burbank, Allison J, Castro, Mario, Alexander, Laura Crotty, Bamdad, Julie, Cardet, Juan Carlos, Comhair, Suzy AA, Covar, Ronina A, DiMango, Emily A, Erwin, Kim, Erzurum, Serpil C, Fahy, John V, Gaffin, Jonathan M, Gaston, Benjamin, Gerald, Lynn B, Hoffman, Eric A, Holguin, Fernando, Jackson, Daniel J, James, John, Jarjour, Nizar N, Kenyon, Nicholas J, Khatri, Sumita, Kirwan, John P, Kraft, Monica, Krishnan, Jerry A, Liu, Andrew H, Liu, Mark C, Marquis, M Alison, Martinez, Fernando, Mey, Jacob, Moore, Wendy C, Moy, James N, Ortega, Victor E, Peden, David B, Pennington, Emily, Peters, Michael C, Ross, Kristie, Sanchez, Maria, Smith, Lewis J, Sorkness, Ronald L, Wechsler, Michael E, Wenzel, Sally E, White, Steven R, Zein, Joe, Zeki, Amir A, Noel, Patricia, Billheimer, Dean, Bleecker, Eugene R, Branch, Emily, Conway, Michelle, Daines, Cori, Deaton, Isaac, Evans, Alexandria, Field, Paige, Francisco, Dave, Hastie, Annette T, Hmieleski, Bob, Krings, Jeffrey O, Liu, Yanqin, Merchen, Janell L, Meyers, Deborah A, Narendran, Nirushan, Peters, Stephen P, Pippins, Anna, Rank, Matthew A, Schunk, Ronald, Skeps, Raymond, Wright, Benjamin, Banzon, Tina M, Bartnikas, Lisa M, Baxi, Sachin N, Betapudi, Vishwanath, Brick, Isabelle, Brockway, Conor, Casale, Thomas B, Castillo-Ruano, Kathleen, Cinelli, Maria Angeles, Crestani, Elena, Cunningham, Amparito, Day-Lewis, Megan, Diaz-Cabrera, Natalie, DiMango, Angela, Esty, Brittany, Fandozzi, Eva, Fernandez, Jesse, and Fitzpatrick, Elizabeth
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Biomedical and Clinical Sciences ,Clinical Sciences ,Clinical Research ,Lung ,Precision Medicine ,Asthma ,Clinical Trials and Supportive Activities ,Respiratory ,Good Health and Well Being ,Advisory Committees ,Biomarkers ,Clinical Protocols ,Clinical Trials ,Phase II as Topic ,Humans ,Research Design ,Severity of Illness Index ,Tomography ,X-Ray Computed ,Severe asthma ,precision medicine ,adaptive clinical trial design ,asthma exacerbation ,type 2 asthma ,non-type 2 asthma ,patient advisory committee ,biomarker ,PrecISE Study Team ,non–type 2 asthma ,Immunology ,Allergy - Abstract
Asthma is a heterogeneous disease, with multiple underlying inflammatory pathways and structural airway abnormalities that impact disease persistence and severity. Recent progress has been made in developing targeted asthma therapeutics, especially for subjects with eosinophilic asthma. However, there is an unmet need for new approaches to treat patients with severe and exacerbation-prone asthma, who contribute disproportionately to disease burden. Extensive deep phenotyping has revealed the heterogeneous nature of severe asthma and identified distinct disease subtypes. A current challenge in the field is to translate new and emerging knowledge about different pathobiologic mechanisms in asthma into patient-specific therapies, with the ultimate goal of modifying the natural history of disease. Here, we describe the Precision Interventions for Severe and/or Exacerbation-Prone Asthma (PrecISE) Network, a groundbreaking collaborative effort of asthma researchers and biostatisticians from around the United States. The PrecISE Network was designed to conduct phase II/proof-of-concept clinical trials of precision interventions in the population with severe asthma, and is supported by the National Heart, Lung, and Blood Institute of the National Institutes of Health. Using an innovative adaptive platform trial design, the PrecISE Network will evaluate up to 6 interventions simultaneously in biomarker-defined subgroups of subjects. We review the development and organizational structure of the PrecISE Network, and choice of interventions being studied. We hope that the PrecISE Network will enhance our understanding of asthma subtypes and accelerate the development of therapeutics for severe asthma.
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- 2022
45. The posterior crescent sign on MRI and MR arthrography: is it a marker of hip dysplasia and instability?
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MacDonald, Andrew A., Blankenbaker, Donna G., Brick, Matthew J., Hanna, Chris M., and Woodward, Rebecca M.
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- 2023
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46. Genome-Wide Association Study and Genomic Prediction for Bacterial Wilt Resistance in Common Bean (Phaseolus vulgaris) Core Collection
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Zia, Bazgha, Shi, Ainong, Olaoye, Dotun, Xiong, Haizheng, Ravelombola, Waltram, Gepts, Paul, Schwartz, Howard F, Brick, Mark A, Otto, Kristen, Ogg, Barry, and Chen, Senyu
- Subjects
Human Genome ,Genetics ,Clinical Research ,common bean ,bacterial wilt ,genome-wide association study ,genomic prediction ,single nucleotide polymorphism ,Phaseolus vulgaris ,Curtobacterium flaccumfaciens pv ,flaccumfaciens ,Curtobacterium flaccumfaciens pv. flaccumfaciens ,Clinical Sciences ,Law - Abstract
Common bean (Phaseolus vulgaris) is one of the major legume crops cultivated worldwide. Bacterial wilt (BW) of common bean (Curtobacterium flaccumfaciens pv. flaccumfaciens), being a seed-borne disease, has been a challenge in common bean producing regions. A genome-wide association study (GWAS) was conducted to identify SNP markers associated with BW resistance in the USDA common bean core collection. A total of 168 accessions were evaluated for resistance against three different isolates of BW. Our study identified a total of 14 single nucleotide polymorphism (SNP) markers associated with the resistance to BW isolates 528, 557, and 597 using mixed linear models (MLMs) in BLINK, FarmCPU, GAPIT, and TASSEL 5. These SNPs were located on chromosomes Phaseolus vulgaris [Pv]02, Pv04, Pv08, and Pv09 for isolate 528; Pv07, Pv10, and Pv11 for isolate 557; and Pv04, Pv08, and Pv10 for isolate 597. The genomic prediction accuracy was assessed by utilizing seven GP models with 1) all the 4,568 SNPs and 2) the 14 SNP markers. The overall prediction accuracy (PA) ranged from 0.30 to 0.56 for resistance against the three BW isolates. A total of 14 candidate genes were discovered for BW resistance located on chromosomes Pv02, Pv04, Pv07, Pv08, and Pv09. This study revealed vital information for developing genetic resistance against the BW pathogen in common bean. Accordingly, the identified SNP markers and candidate genes can be utilized in common bean molecular breeding programs to develop novel resistant cultivars.
- Published
- 2022
47. Barriers and Facilitators of Physical Activity in Adolescents with Intellectual Disabilities: An Analysis Informed by the COM-B Model
- Author
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McDermott, Gary, Brick, Noel E., Shannon, Stephen, Fitzpatrick, Ben, and Taggart, Laurence
- Abstract
Background: Adolescents with intellectual disabilities are insufficiently physically active. Where interventions have been developed and delivered, these have had limited effectiveness, and often lack a theoretical underpinning. Aim: Through application of the COM-B model, our aim is to explore the factors influencing adolescent physical activity within schools. Methods: A qualitative methodology, using focus groups with students who have mild/moderate intellectual disabilities, their parents'/carers' and teachers'. The COM-B model provided the lens through which the data were collected and analysed. Results: We identified of a range of individual, interpersonal, and environmental factors influencing physical activity, across all six COM-B constructs, within the context of the 'school-system'. Conclusion: This is the first study to use the COM-B model to explore school-based physical activity behaviour, for adolescents with intellectual disabilities. Identification of such physical activity behavioural determinants can support the development of effective and sustainable interventions.
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- 2022
- Full Text
- View/download PDF
48. Multilingual Immersive Communication Technology: Repurposing Virtual Reality for Italian Teaching
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Brick, Billy, Cervi-Wilson, Tiziana, Graham, Sean, Tsankov, Tsvetan, Loizou, Michael, Godson, Nina, and Ryan, Kelly
- Abstract
This paper will report on a pilot Virtual Reality (VR) project which repurposes an existing scenario-based VR asset for health sciences. The original scenario aims to prepare health care students for home visits by allowing them to experience a semi-linear conversation with a virtual Non-Player Character (NPC). This provides a safe, non-threatening environment for students to hone the necessary skills they will need once they begin their professional careers. The NPC's simulated emotional state and reactions are changed based on the student's choice of responses. The original scenario was written in English but the opportunity to convert it into an Italian language learning resource by changing the audio files was identified and implemented. The scenario involves learners to be recurrently selecting from a number of possible responses in order to help the virtual character with his grievances regarding his father's care package. [For the complete volume, "New Educational Landscapes: Innovative Perspectives in Language Learning and Technology," see ED596359.]
- Published
- 2019
49. Enhancing Learners' Professional Competence via Duolingo Classroom
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Brick, Billy and Cervi-Wilson, Tiziana
- Abstract
Coventry University Institution Wide Language Programme (IWLP) offers beginners language learning modules to approximately 3,000 students. Each module is taught over 11 weeks for a total of one hour and 40 minutes and two of the weeks are used for in class tests, so tutors generally agree that students need to practise their skills outside the classroom in order to pass the module. One way of doing this was to use the language learning app, Duolingo, which helps students to gradually broaden their linguistic, professional competence, and digital fluency through increased learner autonomy. How effective this approach is, however, has never been measured. The project ran from January to April 2018 and explored whether a correlation exists between regular use of the app by IWLP learners at Common European Framework of Reference (CEFR) level A1 of French, German, Italian, Portuguese, and Spanish, and achieving a high formal coursework assessment mark. The views of both learners and tutors of their experiences of using the software, and the tutor tools provided by Duolingo Schools, will also be canvassed. A virtual classroom was set up within Duolingo Schools for each participating cohort of students and they were encouraged to use the app on a regular basis. The tutor tools allowed the monitoring of how many days learners were active, how many lessons they completed, how many courses they completed, and how many points they were awarded while using Duolingo. These statistics were compared with the overall formal assessment grades on modules and further data was collected at the end of the project from a representative sample of learners (182) and tutors (ten) to establish whether the software influenced module marks. [For the complete volume, "Professional Competencies in Language Learning and Teaching," see ED595297.]
- Published
- 2019
50. Application of experimental design for dispersive liquid–liquid microextraction optimization for metallic impurities determination in arnica infusion employing green solvents
- Author
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Grecco, Giulia Brick, Albini, Kathleen Fioramonte, Longo, Jr., Luiz Sidney, Andreo, Marcio Adriano, Batista, Bruno Lemos, Lourenço, Felipe Rebello, and Calixto, Leandro Augusto
- Published
- 2023
- Full Text
- View/download PDF
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