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14 results on '"Christophe Lagneau"'

1. Nonlinear SAR Modelling of Mosquito Repellents for Skin Application

Author

James Devillers, Adeline Larghi, Valérie Sartor, Marie-Laure Setier-Rio, Christophe Lagneau, and Hugo Devillers

Subjects
repellent, mosquitoes, Aedes aegypti, Structure–Activity Relationship (SAR), artificial neural network, Chemical technology, TP1-1185
Abstract

Finding new marketable mosquito repellents is a complex and time-consuming process that can be optimized via modelling. In this context, a SAR (Structure–Activity Relationship) model was designed from a set of 2171 molecules whose actual repellent activity against Aedes aegypti was available. Information-rich descriptors were used as input neurons of a three-layer perceptron (TLP) to compute the models. The most interesting classification model was a 20/6/2 TLP showing 94% and 89% accuracy on the training set and test set, respectively. A total of 57 other artificial neural network models based on the same architecture were also computed. This allowed us to consider all chemicals both as training and test set members in order to better interpret the results obtained with the selected model. Most of the wrong predictions were explainable. The 20/6/2 TLP model was then used for predicting the potential repellent activity of new molecules. Among them, two were successfully evaluated in vivo.

Published
2023
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2. Variation in the susceptibility of urban Aedes mosquitoes infected with a densovirus

Author

Aurélie Perrin, Anne-Sophie Gosselin-Grenet, Marie Rossignol, Carole Ginibre, Bethsabée Scheid, Christophe Lagneau, Fabrice Chandre, Thierry Baldet, Mylène Ogliastro, and Jérémy Bouyer

Subjects
Medicine, Science
Abstract

Abstract Urban Aedes mosquitoes are vectors of many viruses affecting human health such as dengue, chikungunya and Zika viruses. Insecticide resistance and environmental toxicity risks hamper the effectiveness of chemical control against these mosquito vectors. Alternative control methods, such as the use of mosquito-specific entomopathogenic viruses should be explored. Numerous studies have focused on evaluating the potential of different densoviruses species as biological control agents. However, knowledge on the extent of inter- and intra-specific variations in the susceptibility of Aedes mosquitoes to infection by different densoviruses remains insufficient. In this study, we compared infection and mortality rates induced by the Aedes albopictus densovirus 2 in different strains of Aedes albopictus and Aedes aegypti mosquitoes. The two Aedes species were different in terms of susceptibility to viral infection. Under laboratory conditions, Aedes albopictus densovirus 2 appeared more virulent for the different strains of Aedes aegypti tested than for those of Aedes albopictus. In addition, we also found significant intra-specific variation in infection and mortality rates. Thus, although even if Aedes albopictus densoviruses could be powerful biocontrol agents used in the management of urban Aedes populations, our results also call into question the use of single viral isolate as biocontrol agents.

Published
2020
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3. Efficacy of ULV and thermal aerosols of deltamethrin for control of Aedes albopictus in Nice, France

Author

Saïd C Boubidi, David Roiz, Marie Rossignol, Fabrice Chandre, Romain Benoit, Marc Raselli, Charles Tizon, Bernard Cadiou, Reda Tounsi, Christophe Lagneau, Didier Fontenille, and Paul Reiter

Subjects
Aedes albopictus, ULV, Cold fogging, Thermal fogging, Vector control, Dengue, Infectious and parasitic diseases, RC109-216
Abstract

Abstract Background Ultra-low volume (ULV) insecticidal aerosols dispensed from vehicle-mounted cold-foggers are widely considered the method of choice for control of Aedes aegypti and Ae. albopictus during outbreaks of dengue and chikungunya and, more recently, Zika. Nevertheless, their effectiveness has been poorly studied, particularly in Europe. Nearly all published studies of ULV efficacy are bio-assays based on the mortality of caged mosquitoes. In our study we preferred to monitor the direct impact of treatments on the wild mosquito populations. This study was undertaken to evaluate the efficiency of the two widely used space spraying methods to control Ae. albopictus and Ae. aegypti. Methods We determined the susceptibility of local Ae. albopictus to deltamethrin by two methods: topical application and the “WHO Tube Test”. We used ovitraps baited with hay infusion and adult traps (B-G Sentinel) baited with a patented attractant to monitor the mosquitoes in four residential areas in Nice, southern France. The impact of deltamethrin applied from vehicle-mounted ULV fogging-machines was assessed by comparing trap results in treated vs untreated areas for 5 days before and 5 days after treatment. Four trials were conducted at the maximum permitted application rate (1 g.ha-1). We also made two small-scale tests of the impact of the same insecticide dispensed from a hand-held thermal fogger. Results Susceptibility to the insecticide was high but there was no discernable change in the oviposition rate or the catch of adult female mosquitoes, nor was there any change in the parous rate. In contrast, hand-held thermal foggers were highly effective, with more than 90% reduction of both laid eggs and females. Conclusions We believe that direct monitoring of the wild mosquito populations gives a realistic assessment of the impact of treatments and suggest that the lack of efficacy is due to lack of interaction between the target mosquitoes and the ULV aerosol. We discuss the factors that influence the effectiveness of both methods of spraying in the context of epidemic situations.

Published
2016
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4. Mosquito densoviruses: the revival of a biological control agent against urban Aedes vectors of arboviruses

Author

Marie Rossignol, Jérémy Bouyer, Fabrice Chandre, Aurélie Perrin, Thierry Baldet, Bethsabée Scheid, Anne-Sophie Gosselin-Grenet, Mylène Ogliastro, Carole Ginibre, and Christophe Lagneau

Subjects
Aedes, 0303 health sciences, Aedes albopictus, biology, viruses, fungi, education, 030231 tropical medicine, Biological pest control, virus diseases, Aedes aegypti, medicine.disease, biology.organism_classification, medicine.disease_cause, Virology, 3. Good health, Dengue fever, 03 medical and health sciences, 0302 clinical medicine, medicine, Chikungunya, Densovirus, Aedes albopictus densovirus, 030304 developmental biology
Abstract

Urban Aedes mosquitoes are vectors of many viruses affecting human health such as Dengue, Chikungunya and Zika viruses. Insecticide resistance and environmental toxicity risks hamper the effectiveness of chemical control against these mosquito vectors. Alternative control methods, such as the use of mosquito-specific entomopathogenic viruses should be explored. Numerous studies have focused on evaluating the potential of different densoviruses species as biological control agent. However, knowledge on the extent of inter- and intra-specific variations in the susceptibility of Aedes mosquitoes to infection by different densoviruses remains insufficient. In this study, we compared infection and mortality rates induced by the Aedes albopictus densovirus 2 in different strains of Aedes albopictus and Aedes aegypti mosquitoes. The two Aedes species were different in terms of susceptibility to viral infection. Under laboratory conditions, Aedes albopictus densovirus 2 appeared more virulent for the different strains of Aedes aegypti tested than for those of Aedes albopictus. In addition, we also found significant intra-specific variation in infection and mortality rates. Thus, although even if Aedes albopictus densoviruses could be powerful biocontrol agents used in the management of urban Aedes populations, our results also call into question the use of single viral isolate as biocontrol agents.

Published
2020
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5. Practical management plan for invasive mosquito species in Europe: I. Asian tiger mosquito (Aedes albopictus)

Author

Igor Pajovic, Elena Fălcuţă, Dušan Petrić, Francis Schaffner, Eleonora Flacio, Carla A. Sousa, Claudio Venturelli, Luciano Toma, Carles Aranda, Enkelejda Velo, Bulent Alten, Norbert Becker, Dimitrios P. Papachristos, Ognyan Mikov, Marco Di Luca, Ana Klobučar, Christophe Lagneau, Marlen I. Vasquez, Arjan Stroo, Marco Carrieri, Paola Angelini, Marija Zgomba, Antonios Michaelakis, Enrih Merdić, and Romeo Bellini

Subjects
medicine.medical_specialty, Insecticide resistance, Aedes albopictus, Mosquito Control, Range (biology), 030231 tropical medicine, Infection control, Plan (drawing), Mosquito Vectors, Emergency treatment, medicine.disease_cause, Medical and Health Sciences, Dengue fever, Dengue, 03 medical and health sciences, 0302 clinical medicine, Aedes, Health Sciences, medicine, Animals, 030212 general & internal medicine, Chikungunya, Environmental planning, Insecticide, Management plan, invasive mosquitoes, Aedes albopictus, biology, Public health, Community participation, Yellow fever, Public Health, Environmental and Occupational Health, biology.organism_classification, medicine.disease, Europe, Infectious Diseases, Geography, Tiger mosquito, Introduced Species
Abstract

Aedes albopictus, also known as the “Asian Tiger Mosquito”, is an invasive mosquito species to Europe causing high concern in public health due to its severe nuisance and its vectorial capacity for pathogens such as dengue, chikungunya, yellow fever and Zika. Consequently, the responsible authorities implement management activities to reduce its population density, possibly to below noxious and epidemiological thresholds. In urban areas, these aims are difficult to achieve because of the species’ ability to develop in a wide range of artificial breeding sites, mainly private properties. This document (Management Plan) has been structured to serve as a comprehensive practical and technical guide for stakeholders in organizing the vector control activities in the best possible way. The current plan includes coordinated actions such as standardized control measures and quality control activities, monitoring protocols, activities for stakeholders and local communities, and an emergency vector control plan to reduce the risk of an epidemic.

Published
2020
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6. Vectopole Sud, a french network of platforms for research in medical, veterinary and agricultural entomology

Author

Thierry Baldet, Fabrice Chandre, Isabelle Deme, Magali Eychenne, Katia Grucker, Karine Huber, Christophe Lagneau, Thierry Lefrancois, Sophie Ravel, Bethsabée Scheid, Marie-Laure Setier-Rio, Olivier Adrot, Philippe Solano, Océane Trevennec, Anne-Nathalie Volkoff, Animal, Santé, Territoires, Risques et Ecosystèmes (UMR ASTRE), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Institut National de la Recherche Agronomique (INRA), Maladies infectieuses et vecteurs : écologie, génétique, évolution et contrôle (MIVEGEC), Institut de Recherche pour le Développement (IRD [France-Sud])-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM), Centre National de la Recherche Scientifique (CNRS), Université de Montpellier (UM), Diversité, Génomes & Interactions Microorganismes - Insectes [Montpellier] (DGIMI), Institut National de la Recherche Agronomique (INRA)-Université Montpellier 2 - Sciences et Techniques (UM2)-Université de Montpellier (UM), Entente Interdépartementale pour la Démoustication du Littoral Méditerranéen, Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad), Interactions hôtes-vecteurs-parasites-environnement dans les maladies tropicales négligées dues aux trypanosomatides (UMR INTERTRYP), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Institut de Recherche pour le Développement (IRD)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université de Bordeaux (UB), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Université Claude Bernard Lyon 1 (UCBL), and Université de Lyon-Université de Lyon-Institut de Recherche pour le Développement (IRD)-Université de Bordeaux (UB)

Subjects
[SDV.SA]Life Sciences [q-bio]/Agricultural sciences, [SDV.BA]Life Sciences [q-bio]/Animal biology, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract

Six institutional partners, CIRAD, CNRS, EID Méditerranée, INRA, IRD and the Univer-sity of Montpellier have been working together since 2010 on the issue of arthropod vectors of pathogens that cause infectious diseases in humans and animals, and insect pests responsible for damages to crops. This collaboration for over 8 years has resulted in the creation of “Vectopole Sud”, a Montpellier network of platforms dedicated to re-searches on arthropods of medical, veterinary and agricultural importance. The network draws from the infrastructure and expertise of each partner to improve early warning systems, monitoring, control of pests and vectors in order to protect hu-man health, agriculture and livestock production. The network has received continuous funding by the French Government and the Occitanie Region enabling it to modernize its different laboratories and rearing facilities and support the research activities. Vectopole Sud includes four experimental platforms, confined insectariums and associ-ated laboratories, which are open to national and international partners. Overall, the Vec-topole Sud has a network of partners in Europe and tropical regions worldwide, notably through IRD and CIRAD, two French institutions supporting research for development. Vectopole Sud brings together over 400 researchers and technicians from five research units belonging to the Montpellier University of Excellence and Agropolis International scientific communities. It conducts multidisciplinary research and expertise on biolo-gy, public & animal health, ecology, environmental science, genetics, and evolutionary medicine. It contributes to a better environment, animal health and human wellbeing through an integrated One Health approach, by fighting human and animal diseases to ensure more productive and sustainable farming systems (food security). We will present the different platforms of the Vectopole Sud network, its various activi-ties (infrastructures, research, services and training) as well as its different perspectives. www.vectopole-sud.fr

Published
2018

9. Synthesis of retinoid analogues of juvenile hormones

Author

André Yébakima, Lotfi Doumandji, Christophe Lagneau, Armand Lattes, Jean-Pierre Doucet, Hubert Matondo, Annick Doucet-Panaye, James Devillers, Sébastien Estaran, Boudjema Hamada, Institut des Biomolécules Max Mousseron [Pôle Chimie Balard] (IBMM), Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Institut de Chimie du CNRS (INC)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Entente Interdépartementale pour la Démoustication du Littoral Méditerranéen, Centre Traitement Informatique Scientifique (CTIS), Centre de la Démoustication, Conseil General de la Martinique, Interfaces, Traitements, Organisation et Dynamique des Systèmes (ITODYS (UMR_7086)), Université Paris Diderot - Paris 7 (UPD7)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Interactions moléculaires et réactivité chimique et photochimique (IMRCP), Institut de Chimie de Toulouse (ICT), Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Institut Ecologie et Environnement (INEE), Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS)-Fédération de Recherche Fluides, Energie, Réacteurs, Matériaux et Transferts (FERMAT), Institut National des Sciences Appliquées - Toulouse (INSA Toulouse), Institut National des Sciences Appliquées (INSA)-Université de Toulouse (UT)-Institut National des Sciences Appliquées (INSA)-Université de Toulouse (UT)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Institut National des Sciences Appliquées - Toulouse (INSA Toulouse), Institut National des Sciences Appliquées (INSA)-Université de Toulouse (UT)-Institut National des Sciences Appliquées (INSA)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS), Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Université Paris Diderot - Paris 7 (UPD7), Centre National de la Recherche Scientifique (CNRS)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut de Chimie de Toulouse (ICT-FR 2599), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Institut de Recherche pour le Développement (IRD)-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées, Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Institut de Chimie de Toulouse (ICT-FR 2599), Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Institut de Chimie du CNRS (INC)-Institut National Polytechnique (Toulouse) (Toulouse INP), and Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)

Subjects
010405 organic chemistry, medicine.drug_class, Chemistry, Retinoic acid, General Chemistry, 010402 general chemistry, 01 natural sciences, 3. Good health, 0104 chemical sciences, Inorganic Chemistry, chemistry.chemical_compound, Biochemistry, Mosquito larvae, Juvenile hormone, Trifluoromethyl ketone, medicine, [CHIM]Chemical Sciences, Mitsunobu reaction, Retinoid, ComputingMilieux_MISCELLANEOUS
Abstract

As part of a collaborative research project aimed at designing new chemicals active on mosquito larvae, we sought accessible raw materials and an efficient synthesis method for preparing large amounts of active substances. For this we selected retinoic acid, which has functionality close to that of juvenile hormones. From this molecule we developed ester and trifluoromethyl ketone synthesis that was fast and led to good yields.

Published
2017
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11. Relating fitness to long-term environmental variations in natura

Author

Mylène Weill, Pierrick Labbé, Christophe Lagneau, Thomas Lenormand, Pascal Milesi, Institut des Sciences de l'Evolution de Montpellier (UMR ISEM), École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université de Montpellier (UM)-Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Centre National de la Recherche Scientifique (CNRS)-Institut de recherche pour le développement [IRD] : UR226, Centre d’Ecologie Fonctionnelle et Evolutive (CEFE), Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre international d'études supérieures en sciences agronomiques (Montpellier SupAgro)-Institut National de la Recherche Agronomique (INRA)-Université Paul-Valéry - Montpellier 3 (UPVM)-Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro), Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut de Recherche pour le Développement (IRD [France-Sud]), 'Personal Protection Against Vectors' working group (PPAV), PPAV working group, Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-École pratique des hautes études (EPHE)-Université de Montpellier (UM)-Institut de recherche pour le développement [IRD] : UR226-Centre National de la Recherche Scientifique (CNRS), Université Paul-Valéry - Montpellier 3 (UM3)-Institut National de la Recherche Agronomique (INRA)-Centre international d'études supérieures en sciences agronomiques (Montpellier SupAgro)-École pratique des hautes études (EPHE)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud])-Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-École Pratique des Hautes Études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université de Montpellier (UM)-Institut de recherche pour le développement [IRD] : UR226-Centre National de la Recherche Scientifique (CNRS), Université Paul-Valéry - Montpellier 3 (UPVM)-Institut National de la Recherche Agronomique (INRA)-Centre international d'études supérieures en sciences agronomiques (Montpellier SupAgro)-École Pratique des Hautes Études (EPHE), and Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud])-Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro)

Subjects
0106 biological sciences, 0301 basic medicine, Insecticides, Population genetics, Locus (genetics), Biology, 010603 evolutionary biology, 01 natural sciences, adaptation dynamics, Evolution, Molecular, 03 medical and health sciences, Genetics, Animals, Allele, Alleles, Ecology, Evolution, Behavior and Systematics, Continuous evolution, population genetics model, Ecology, long-term survey, insecticide resistance, Culex, Mosquito control, Genetics, Population, 030104 developmental biology, Insecticide resistance, [SDE]Environmental Sciences, selective pressure variations, Evolutionary ecology, France, Genetic Fitness, [SDE.BE]Environmental Sciences/Biodiversity and Ecology
Abstract

International audience; Quantifying links between ecological processes and adaptation dynamics in natura remains a crucial challenge. Many studies have documented the strength, form and direction of selection, and its variations in space and time, but only a few managed to link these variations to their proximal causes. This step is, however, crucial, if we are to understand how the variation in selective pressure affects adaptive allele dynamics in natural settings. We used data from a long-term survey (about 30 years) monitoring the adaptation to insecticides of Culex pipiens mosquitoes in Montpellier area (France), focusing on three resistance alleles of the Ester locus. We used a population genetics model taking temporal and spatial variations in selective pressure into account, to assess the quantitative relationships between variations in the proximal agent of selection (amounts of insecticide sprayed) and the fitness of resistance alleles. The response to variations in selective pressure was fast, and the alleles displayed different fitness-to-environment relationships: the analyses revealed that even slight changes in insecticide doses could induce changes in the strength and direction of selection, thus changing the fitness ranking of the adaptive alleles. They also revealed that selective pressures other than the insecticides used for mosquito control affected the resistance allele dynamics. These fitness-to-environment relationships, fast responses and continuous evolution limit our ability to predict the outcome of adaptive allele dynamics in a changing environment, but they clearly contribute to the maintenance of polymorphism in natural populations. Our study also emphasizes the necessity of long-term surveys in evolutionary ecology.

Published
2016
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12. Gender bias in insecticide susceptibility of Aedes albopictus is solely attributable to size

Author

Didier Fontenille, Reda Tounsi, Paul Reiter, Marie Rossignol, Saïd C. Boubidi, Fabrice Chandre, Christophe Lagneau, EID Méditerranée (EID Méditerranée), Etablissement public administratif, Institut Pasteur d'Algérie, Réseau International des Instituts Pasteur (RIIP), Vector Control Group (MIVEGEC-VCG), Evolution des Systèmes Vectoriels (ESV), Maladies infectieuses et vecteurs : écologie, génétique, évolution et contrôle (MIVEGEC), Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud])-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud])-Maladies infectieuses et vecteurs : écologie, génétique, évolution et contrôle (MIVEGEC), Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud])-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud]), Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud]), Institut Pasteur du Cambodge, Insectes et Maladies Infectieuses, Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS), and Institut Pasteur [Paris]-Centre National de la Recherche Scientifique (CNRS)

Subjects
0106 biological sciences, Insecticides, Aedes albopictus, Mosquito Control, 030231 tropical medicine, sterile insect technique, [STAT.OT]Statistics [stat]/Other Statistics [stat.ML], 01 natural sciences, World health, mosquito control, Toxicology, 03 medical and health sciences, Sterile insect technique, 0302 clinical medicine, Sex Factors, Aedes, Nitriles, Pyrethrins, Gender bias, male size, Dose effect, Bioassay, Animals, Body Size, Ecology, Evolution, Behavior and Systematics, biology, [SDV.BA]Life Sciences [q-bio]/Animal biology, insecticide susceptibility, Significant difference, Public Health, Environmental and Occupational Health, General Medicine, biology.organism_classification, 3. Good health, 010602 entomology, Mosquito control, Insect Science
Abstract

International audience; Despite an extensive literature on mosquitoes, remarkably little attention has been paid to males. Current interest in control by release of transgenic males begs attention to this bias. It is well known that males are more susceptible to insecticides than females when determined by the standard World Health Organization (WHO) bioassay, and field observations have shown a higher impact of ultra-low-volume (ULV) space sprays. It is generally assumed that these differences are due to the smaller size of males and/or greater physiological susceptibility. We compared susceptibility by WHO bioassay and by topical application. There was a significant difference between the sexes in terms of dose effect and knockdown by the WHO test, but no significant difference by weight-adjusted topical application. We conclude that greater susceptibility of males is solely a function of their size and suggest that a ULV treatment before the release of transgenic males would greatly increase their competitive ratio versus wild mosquitoes and thus their impact as a control measure.

Published
2016
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13. Efficacy of ULV and thermal aerosols of deltamethrin for control of Aedes albopictus in Nice, France

Author

Charles Tizon, Romain Benoit, Marie Rossignol, Bernard Cadiou, Didier Fontenille, David Roiz, Reda Tounsi, Saïd C. Boubidi, Marc Raselli, Christophe Lagneau, Paul Reiter, Fabrice Chandre, EID Méditerranée (EID Méditerranée), Etablissement public administratif, Institut Pasteur d'Algérie, Réseau International des Instituts Pasteur (RIIP), Vector Control Group (MIVEGEC-VCG), Evolution des Systèmes Vectoriels (ESV), Maladies infectieuses et vecteurs : écologie, génétique, évolution et contrôle (MIVEGEC), Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud])-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud])-Maladies infectieuses et vecteurs : écologie, génétique, évolution et contrôle (MIVEGEC), Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud])-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud]), EID Méditerranée, Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud]), Institut Pasteur du Cambodge, Insectes et Maladies Infectieuses, Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS), The research was funded by the European Commission under the 7th Framework, Grant Agreement Number: 282589, We would like to thank Thierry Baldet of IDRC/CRDI–Ottawa, Canada and Annelies Wilder-Smith of University of Umea, Umea, Sweden for useful discussions and advices for the work. Our thanks also to Xavier Allen of CIRAD, UMR15 CMAEE, INRA, Montpellier, France for providing blood for the mosquito rearing and Arnaud Cannet and Pascal Delaunay of Inserm U1065, Centre Méditerranéen de Médecine Moléculaire, C3 M, Université de Nice-Sophia Antipolis for their technical help and all the staff of EID Méditerranée, Montpellier, France for their help in field trials., European Project: 282589,EC:FP7:HEALTH,FP7-HEALTH-2011-single-stage,DENGUETOOLS(2011), and Institut Pasteur [Paris]-Centre National de la Recherche Scientifique (CNRS)

Subjects
Insecticides, Veterinary medicine, Mosquito Control, Aedes albopictus, 030231 tropical medicine, Thermal fogging, Context (language use), Aedes aegypti, medicine.disease_cause, lcsh:Infectious and parasitic diseases, Toxicology, Dengue, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, ULV, Aedes, Nitriles, Pyrethrins, parasitic diseases, medicine, Animals, lcsh:RC109-216, 030212 general & internal medicine, Chikungunya, Cold fogging, Aerosols, biology, Research, fungi, Temperature, biology.organism_classification, Vector control, 3. Good health, Mosquito control, Infectious Diseases, Deltamethrin, [SDV.MP]Life Sciences [q-bio]/Microbiology and Parasitology, chemistry, Fogger, Biological Assay, Parasitology, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, France
Abstract

Background Ultra-low volume (ULV) insecticidal aerosols dispensed from vehicle-mounted cold-foggers are widely considered the method of choice for control of Aedes aegypti and Ae. albopictus during outbreaks of dengue and chikungunya and, more recently, Zika. Nevertheless, their effectiveness has been poorly studied, particularly in Europe. Nearly all published studies of ULV efficacy are bio-assays based on the mortality of caged mosquitoes. In our study we preferred to monitor the direct impact of treatments on the wild mosquito populations. This study was undertaken to evaluate the efficiency of the two widely used space spraying methods to control Ae. albopictus and Ae. aegypti. Methods We determined the susceptibility of local Ae. albopictus to deltamethrin by two methods: topical application and the “WHO Tube Test”. We used ovitraps baited with hay infusion and adult traps (B-G Sentinel) baited with a patented attractant to monitor the mosquitoes in four residential areas in Nice, southern France. The impact of deltamethrin applied from vehicle-mounted ULV fogging-machines was assessed by comparing trap results in treated vs untreated areas for 5 days before and 5 days after treatment. Four trials were conducted at the maximum permitted application rate (1 g.ha-1). We also made two small-scale tests of the impact of the same insecticide dispensed from a hand-held thermal fogger. Results Susceptibility to the insecticide was high but there was no discernable change in the oviposition rate or the catch of adult female mosquitoes, nor was there any change in the parous rate. In contrast, hand-held thermal foggers were highly effective, with more than 90% reduction of both laid eggs and females. Conclusions We believe that direct monitoring of the wild mosquito populations gives a realistic assessment of the impact of treatments and suggest that the lack of efficacy is due to lack of interaction between the target mosquitoes and the ULV aerosol. We discuss the factors that influence the effectiveness of both methods of spraying in the context of epidemic situations. Electronic supplementary material The online version of this article (doi:10.1186/s13071-016-1881-y) contains supplementary material, which is available to authorized users.

Published
2016
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14. No association between the use of Bti for mosquito control and the dynamics of non-target aquatic invertebrates in French coastal and continental wetlands: No association between the use of Bti for mosquito control and the dynamics of non-target aquatic invertebrates in French coastal and continental wetlands

Author

Eduard Szöcs, Christophe Lagneau, Céline Bertrand, Benoît Francés, Laurent Lagadic, Benoit Le Hunsec, Stéphanie Fayolle, Yves Rozier, Evelyne Franquet, Ralf B. Schäfer, Sébastien Chouin, Claire Duchet, Marc Roucaute, Rémi Foussadier, Jérôme de Maupeou, Jean-Baptiste Santoni, Écologie et santé des écosystèmes (ESE), Institut National de la Recherche Agronomique (INRA)-AGROCAMPUS OUEST, Institute of Environmental Sciences [Landau], University of Koblenz-Landau, Institut méditerranéen de biodiversité et d'écologie marine et continentale (IMBE), Avignon Université (AU)-Aix Marseille Université (AMU)-Institut de recherche pour le développement [IRD] : UMR237-Centre National de la Recherche Scientifique (CNRS), EID Rhône-Alpes, 'Personal Protection Against Vectors' working group (PPAV), PPAV working group, AGROCAMPUS OUEST, Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Centre National de la Recherche Scientifique (CNRS)-Institut de recherche pour le développement [IRD] : UMR237-Aix Marseille Université (AMU)-Avignon Université (AU), Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-INSTITUT AGRO Agrocampus Ouest, and Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)

Subjects
Bacillus thuringiensis israelensis, 0106 biological sciences, Insecticides, [SDV.BIO]Life Sciences [q-bio]/Biotechnology, Environmental Engineering, Mosquito Control, Aquatic non-target invertebrates, Wetland, 010501 environmental sciences, Biology, 010603 evolutionary biology, 01 natural sciences, Hemolysin Proteins, Chironomids, Bacterial Proteins, Environmental monitoring, Environmental Chemistry, Animals, Ecosystem, Pest Control, Biological, Waste Management and Disposal, 0105 earth and related environmental sciences, Invertebrate, geography, geography.geographical_feature_category, Bacillus thuringiensis Toxins, [SDE.IE]Environmental Sciences/Environmental Engineering, Ecology, Flooding (psychology), Pollution, Invertebrates, Endotoxins, Mosquito control, Habitat, Wetlands, France, Biopesticide, [SDE.BE]Environmental Sciences/Biodiversity and Ecology, Field biomonitoring, Environmental Monitoring
Abstract

International audience; The environmental safety of Bacillus thuringiensis subsp. israelensis (Bti) is still controversial, mainly because most of the previous field studies on its undesired effects were spatially limited and did not address the relationship between community similarity and application time and frequency. No general statement can therefore be drawn on the usage conditions of Bti that insure protection of non-target organisms. The present study was conducted in eight sites distributed over the main geographical sectors where mosquito control is implemented in mainland France and Corsica. Changes in non-target aquatic invertebrates were followed at elapsed time after repeated applications of two Bti formulations (VectoBac (R) WDG or 12AS) up to four consecutive years. We examined the influence of both larvicide treatments and environmental variables on community dynamics and dissimilarity between treated and control areas. As it can be argued that chironomids are the most vulnerable group of non-target invertebrates, we scrutinised potential Bti-related effects on the dynamics of their community. The use of VectoBac (R) WDG and 12AS in coastal and continental wetlands had no immediate or long-term detectable effect on the taxonomic structure and taxa abundance of non-target aquatic invertebrate communities, including chironomids. This applied to the main habitats where mosquito larvae occur, regardless of their geographic location. Flooding, whose frequency and duration depend on local meteorological and hydrological conditions, was identified as the main environmental driver of invertebrate community dynamics. Our findings add support to the environmental safety of currently available Bti formulations when following recommended application rates and best mosquito control practices. (C) 2016 Elsevier B.V. All rights reserved.

Published
2015
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