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4 results on '"Cpc-PH"'

1. Ventricular interdependent phenotype of mixed Cpc‐pulmonary hypertension and HFpEF with normal left atrium: Impact on CPET metrics and clinical outcomes.

Author

Zampierollo‐Jaramillo, Giovanna, Abed, Anas, El Shaer, Ahmed, Garcia‐Arango, Mariana, Chen, Yimin, Tehrani, Babak, Tu, Wanxin, Arif, Abdul Wahab, Heffernan, Shannon, Esmaeeli, Amir, Sahai, Aditya, Runo, James, Baber, Aurangzeb, Masri, Sofia C., and Raza, Farhan

Subjects
*LEFT heart atrium, *VENTRICULAR ejection fraction, *HEART failure, *HEMODYNAMICS, *TREATMENT effectiveness
Abstract

Among 45 CpcPH/heart failure with preserved ejection fraction participants, 11 with normal left atrium (compared to 34 with abnormal left atrium, p < 0.05 for all) had low left ventricle (LV) transmural pressure (2.9 ± 2.4 vs. 6.2 ± 2.9 mmHg), and increased right ventricle (RV):LV ratio (2.41 ± 1.09 vs. 1.46 ± 0.66) and interventricular septal angle (149 ± 8 vs. 136 ± 10), indicating exaggerated ventricular interdependence from a dilated RV. [ABSTRACT FROM AUTHOR]

Published
2024
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2. Ventricular Interdependent Phenotype of Mixed Cpc-Pulmonary Hypertension and HFpEF with Normal Left Atrium: Impact on CPET Metrics and Clinical Outcome

Author

Zampierollo-Jaramillo, Giovanna, Abed, Anas, El Shaer, Ahmed, Garcia-Arango, Mariana, Chen, Yimin, Tehrani, Babak, Tu, Wanxin, Arif, Abdul Wahab, Heffernan, Shannon, Esmaeeli, Amir, Sahai, Aditya, Runo, James, Masri, Sofia C., Raza, Farhan, Zampierollo-Jaramillo, Giovanna, Abed, Anas, El Shaer, Ahmed, Garcia-Arango, Mariana, Chen, Yimin, Tehrani, Babak, Tu, Wanxin, Arif, Abdul Wahab, Heffernan, Shannon, Esmaeeli, Amir, Sahai, Aditya, Runo, James, Masri, Sofia C., and Raza, Farhan

Abstract

Among 45 CpcPH/heart failure with preserved ejection fraction participants, 11 with normal left atrium (compared to 34 with abnormal left atrium, p < 0.05 for all) had low left ventricle (LV) transmural pressure (2.9 ± 2.4 vs. 6.2 ± 2.9 mmHg), and increased right ventricle (RV):LV ratio (2.41 ± 1.09 vs. 1.46 ± 0.66) and interventricular septal angle (149 ± 8 vs. 136 ± 10), indicating exaggerated ventricular interdependence from a dilated RV

Published
2024

3. Right ventricular outflow tract velocity time integral-to-pulmonary artery systolic pressure ratio: a non-invasive metric of pulmonary arterial compliance differs across the spectrum of pulmonary hypertension

Author

Jonathan Menachem, Edo Y. Birati, Sula Mazimba, Steven M. Kawut, E. Wilson Grandin, Jeremy A. Mazurek, Gregory S. Troutman, Monique S. Tanna, Payman Zamani, Priyanka Bhattacharya, Anjali Vaidya, Julio A. Chirinos, Frances Mao, Paul R. Forfia, Kerri Akaya Smith, and Arieh L. Fox

Subjects
Pulmonary and Respiratory Medicine, medicine.medical_specialty, lcsh:Diseases of the circulatory (Cardiovascular) system, non-invasive, 030204 cardiovascular system & hematology, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, medicine.artery, pulmonary hypertension, medicine, Ventricular outflow tract, cardiovascular diseases, lcsh:RC705-779, business.industry, Non invasive, Stroke volume, lcsh:Diseases of the respiratory system, medicine.disease, Pulmonary hypertension, Pulse pressure, Compliance (physiology), Blood pressure, 030228 respiratory system, lcsh:RC666-701, Pulmonary artery, Cardiology, pulmonary arterial compliance, Cpc-PH, business, Research Article
Abstract

Pulmonary arterial compliance (PAC), invasively assessed by the ratio of stroke volume to pulmonary arterial (PA) pulse pressure, is a sensitive marker of right ventricular (RV)-PA coupling that differs across the spectrum of pulmonary hypertension (PH) and is predictive of outcomes. We assessed whether the echocardiographically derived ratio of RV outflow tract velocity time integral to PA systolic pressure (RVOT-VTI/PASP) (a) correlates with invasive PAC, (b) discriminates heart failure with preserved ejection-associated PH (HFpEF-PH) from pulmonary arterial hypertension (PAH), and (c) is associated with functional capacity. We performed a retrospective cohort study of patients with PAH (n = 70) and HFpEF-PH (n = 86), which was further dichotomized by diastolic pressure gradient (DPG) into isolated post-capillary PH (DPG

Published
2019

4. Right ventricular outflow tract velocity time integral-to-pulmonary artery systolic pressure ratio: a non-invasive metric of pulmonary arterial compliance differs across the spectrum of pulmonary hypertension.

Author

Bhattacharya PT, Troutman GS, Mao F, Fox AL, Tanna MS, Zamani P, Grandin EW, Menachem JN, Birati EY, Chirinos JA, Mazimba S, Smith KA, Kawut SM, Forfia PR, Vaidya A, and Mazurek JA

Abstract

Pulmonary arterial compliance (PAC), invasively assessed by the ratio of stroke volume to pulmonary arterial (PA) pulse pressure, is a sensitive marker of right ventricular (RV)-PA coupling that differs across the spectrum of pulmonary hypertension (PH) and is predictive of outcomes. We assessed whether the echocardiographically derived ratio of RV outflow tract velocity time integral to PA systolic pressure (RVOT-VTI/PASP) (a) correlates with invasive PAC, (b) discriminates heart failure with preserved ejection-associated PH (HFpEF-PH) from pulmonary arterial hypertension (PAH), and (c) is associated with functional capacity. We performed a retrospective cohort study of patients with PAH (n = 70) and HFpEF-PH (n = 86), which was further dichotomized by diastolic pressure gradient (DPG) into isolated post-capillary PH (DPG < 7 mmHg; Ipc-PH, n = 54), and combined post- and pre-capillary PH (DPG ≥ 7 mm Hg; Cpc-PH, n = 32). Of the 156 patients, 146 had measurable RVOT-VTI or PASP and were included in further analysis. RVOT-VTI/PASP correlated with invasive PAC overall (ρ = 0.61, P < 0.001) and for the PAH (ρ = 0.38, P = 0.002) and HFpEF-PH (ρ = 0.63, P < 0.001) groups individually. RVOT-VTI/PASP differed significantly across the PH spectrum (PAH: 0.13 [0.010-0.25] vs. Cpc-PH: 0.20 [0.12-0.25] vs. Ipc-PH: 0.35 [0.22-0.44]; P < 0.001), distinguished HFpEF-PH from PAH (AUC = 0.72, 95% CI = 0.63-0.81) and Cpc-PH from Ipc-PH (AUC = 0.78, 95% CI = 0.68-0.88), and remained independently predictive of 6-min walk distance after multivariate analysis (standardized β-coefficient = 27.7, 95% CI = 9.2-46.3; P = 0.004). Echocardiographic RVOT-VTI/PASP is a novel non-invasive metric of PAC that differs across the spectrum of PH. It distinguishes the degree of pre-capillary disease within HFpEF-PH and is predictive of functional capacity.

Published
2019
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