49 results on '"Erik Popp"'
Search Results
2. Perennial disaster patterns in Central Europe since 2000 and implications for hospital preparedness planning – a cross-sectional analysis
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Maik von der Forst, Maximilian Dietrich, Felix C. F. Schmitt, Erik Popp, and Markus Ries
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Disaster ,Mass casualty incident ,Natural hazard ,Hospital disaster planning ,Critical infrastructure ,Technological hazard ,Medicine ,Science - Abstract
Abstract The goal of this analysis is to describe seasonal disaster patterns in Central Europe in order to raise awareness and improve hospital disaster planning and resilience, particularly during peak events. Hospitals are essential pillars of a country’s critical infrastructure, vital for sustaining healthcare services and supporting public well-being—a key issue of national security. Disaster planning for hospitals is crucial to ensure their functionality under special circumstances. But the impact of climate change and seasonal variations in the utilization of hospital services are raising challenges. Therefore, the knowledge of perennial disaster patterns could help strengthen the resilience of hospitals. We conducted a cross-sectional analysis of the Emergency Events Database EM-DAT for disasters in Central Europe (Germany, France, Denmark, The Netherlands, Belgium, Luxembourg, Switzerland, Austria, Czech Republic, and Poland) between January 2000 and December 2023. Time distribution of disasters, patterns and longitudinal trends, were analyzed to discuss impact on disaster preparedness in hospitals. Out of 474 events, 83% were associated with a natural hazard and only 80 events (17%) were of technological cause. While technological disasters were spread equally over the whole year, the vast majority of disasters related to natural hazards (n = 394), i.e. storms (n = 178, 45%), floods (n = 101, 26%), and extreme temperatures (n = 93, 24%) peaked during summer and winter months. Fewer disasters were registered during autumn and especially spring seasons. More than 50% of the technological disasters were categorized in the transport accident subgroup. Technological disasters were spread equally over the whole year. Looking at the three most common disaster types, extreme temperatures, floods, and storms are clearly dominating and cause over 90% of the disasters due to natural hazards in central Europe. Overall, the number of events per year fluctuates without a clear trend, only the technological events appear to become less frequent with 70% (n = 56) of the registered disasters occurring in the first half of the study period (2000–2011). An overlap of hospital admissions due to seasonal effects and catastrophic events, mainly triggered by disasters of natural cause in vulnerable periods may lead to a partial collapse of the health care system. To close knowledge gaps, future comprehensive data collection is vital for informed decision-making. Awareness and preparedness are key: an "all-hazards" approach to manage diverse, potentially simultaneous seasonal threats is often the most versatile strategy for hospital emergency planning.
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- 2025
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3. Out-of-hospital cardiac arrest treated with prehospital double sequential external defibrillation during eCPR in refractory VF — a case report
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Stephan Katzenschlager, Raphael Heck, Erik Popp, Frank Weilbacher, Markus A. Weigand, Christoph Eisner, and Christopher Neuhaus
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Resuscitation ,Extracorporeal cardiopulmonary resuscitation ,Double sequential external defibrillation ,Advanced life support ,Case report ,Medical emergencies. Critical care. Intensive care. First aid ,RC86-88.9 - Abstract
Abstract Background Double sequential external defibrillation (DSED) has demonstrated increased survival with good neurological outcome in a recent randomized controlled trial. DSED has not been studied in patients with extracorporeal cardiopulmonary resuscitation (eCPR). Case We present the first case of prehospital eCPR with ongoing refractory ventricular fibrillation (VF), terminated by DSED. After six shocks, return of spontaneous circulation was initially achieved; however, the patient went into recurrent VF. ECPR was performed prehospital, with VF still refractory after three more shocks. DSED successfully terminated VF and showed a further increase in etCO2 and near-infrared spectroscopy cerebral oximetry values. Conclusion DSED can be a sufficient strategy for patients in refractory VF while on eCPR and should be evaluated in further studies.
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- 2023
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4. Severe trauma associated cardiac failure
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Maximilian Dietrich, Frank Weilbacher, Stephan Katzenschlager, Markus A. Weigand, and Erik Popp
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Traumatic cardiac arrest (TCA) ,Cardiac failure ,Transfusion-associated cardiac overload (TACO) ,Advanced trauma care ,Severe Trauma associated Cardiac Failure (STAC) ,Medical emergencies. Critical care. Intensive care. First aid ,RC86-88.9 - Abstract
Abstract Although significant efforts have been made to enhance trauma care, the mortality rate for traumatic cardiac arrest (TCA) remains exceedingly high. Therefore, our institution has implemented special measures to optimize the treatment of major trauma patients. These measures include a prehospital Medical Intervention Car (MIC) and a ‘code red’ protocol in the trauma resuscitation room for patients with TCA or shock. These measures enable the early treatment of reversible causes of TCA and have resulted in a significant number of patients achieving adequate ROSC. However, a significant proportion of these patients still die due to circulatory failure shortly after. Our observations from patients who underwent clamshell thoracotomy or received echocardiographic evaluation in conjunction with current scientific findings led us to conclude that dysfunction of the heart itself may be the cause. Therefore, we propose discussing severe trauma-associated cardiac failure (STAC) as a new entity to facilitate scientific research and the development of specific treatment strategies, with the aim of improving the outcome of severe trauma.
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- 2024
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5. Out-of-hospital cardiac arrest in children: an epidemiological study based on the German Resuscitation Registry identifying modifiable factors for return of spontaneous circulation
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Stephan Katzenschlager, Inga K. Kelpanides, Patrick Ristau, Matthias Huck, Stephan Seewald, Sebastian Brenner, Florian Hoffmann, Jan Wnent, Jo Kramer-Johansen, Ingvild B. M. Tjelmeland, Markus A. Weigand, Jan-Thorsten Gräsner, and Erik Popp
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Out-of-hospital cardiac arrest ,Resuscitation ,Paediatric cardiac arrest ,Emergency medical service ,Epidemiology ,Medical emergencies. Critical care. Intensive care. First aid ,RC86-88.9 - Abstract
Abstract Aim This work provides an epidemiological overview of out-of-hospital cardiac arrest (OHCA) in children in Germany between 2007 and 2021. We wanted to identify modifiable factors associated with survival. Methods Data from the German Resuscitation Registry (GRR) were used, and we included patients registered between 1st January 2007 and 31st December 2021. We included children aged between > 7 days and 17 years, where cardiopulmonary resuscitation (CPR) was started, and treatment was continued by emergency medical services (EMS). Incidences and descriptive analyses are presented for the overall cohort and each age group. Multivariate binary logistic regression was performed on the whole cohort to determine the influence of (1) CPR with/without ventilation started by bystander, (2) OHCA witnessed status and (3) night-time on the outcome hospital admission with return of spontaneous circulation (ROSC). Results OHCA in children aged 1 year. Bystander-witnessed OHCA and bystander CPR rate were highest in children aged 1–4 years, with 43.9% and 62.3%, respectively. In reference to EMS-started CPR, bystander CPR with ventilation were associated with an increased odds ratio for ROSC at hospital admission after adjusting for age, sex, year of OHCA and location of OHCA. Conclusion This study provides an epidemiological overview of OHCA in children in Germany and identifies bystander CPR with ventilation as one primary factor for survival. Trial registrations German Clinical Trial Register: DRKS00030989, December 28th 2022. Graphical Abstract
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- 2023
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6. Paediatric out-of-hospital cardiac arrest: Time to update registries?
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Stephan Katzenschlager, Inga K. Kelpanides, Eirik Skogvoll, Guro Grindheim, Jan Wnent, Erik Popp, Markus A. Weigand, Jo Kramer-Johansen, Ingvild B. M. Tjelmeland, and Jan-Thorsten Gräsner
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Medical emergencies. Critical care. Intensive care. First aid ,RC86-88.9 - Published
- 2023
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7. Implementation of hyperspectral imaging in a trauma resuscitation room: a randomized controlled trial
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Stephan Katzenschlager, Maximilian Dietrich, Franziska Peterstorfer, Katharina Manten, Maik von der Forst, Rouven Behnisch, Christine Leowardi, Alexander Studier-Fischer, Felix Nickel, Markus A. Weigand, Frank Weilbacher, and Erik Popp
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Trauma ,Shock ,Microcirculation ,Hyperspectral imaging ,Diagnostics ,Medical emergencies. Critical care. Intensive care. First aid ,RC86-88.9 - Abstract
Abstract Background Hyperspectral imaging (HSI) is a novel imaging technology with the ability to assess microcirculatory impairment. We aimed to assess feasibility of performing HSI, a noninvasive, contactless method to assess microcirculatory alterations, during trauma resuscitation care. Methods This randomized controlled clinical trial was conducted in a dedicated trauma resuscitation room of a level one trauma center. We included adult patients who were admitted to the trauma resuscitation room. Patients were allocated in a 1:1 ratio to the HSI group (intervention) or control group. In addition to the standard of care, patients in the intervention group had two hyperspectral recordings (HSR) of their hand palm taken. Primary outcomes were the treatment duration of the primary survey (until end of ABCDE-evaluation, ultrasound and evaluation by the trauma team) and the total resuscitation room care (until transport to definitive care) as well as the ability to perform measurements from all HSR. Secondary outcomes were analyses from the intervention group compared to HSI measurements of 26 healthy volunteers including an analysis based on the ISS (Injury severity score) (
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- 2022
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8. Case report: Resuscitative endovascular balloon occlusion after iatrogenic injury of the common iliac artery during neurosurgical dorsal lumbar microdiscectomy
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Mascha O. Fiedler, Dittmar Böckler, Henrik Giese, Erik Popp, Felix C. F. Schmitt, Markus A. Weigand, and Philipp Erhart
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REBOA ,iatrogenic bleeding ,lumbar spine surgery ,endovascular aortic occlusion ,case report ,Medicine (General) ,R5-920 - Abstract
Introduction and importanceThis case report describes resuscitative endovascular balloon occlusion (REBOA) of the aorta in a patient with life-threatening iatrogenic bleeding of the right common iliac artery during elective dorsal lumbar spine surgery. REBOA is an emergency procedure for temporary intra-aortic balloon occlusion being increasingly reported and published since its inauguration in 1954. The interdisciplinary management of hemorrhage and technical notes for a successful REBOA procedure will be presented.Case presentationA 53-year-old female patient was admitted to the neurosurgery clinic suffering from left-sided L5 radiculopathy. During surgery, the anterior longitudinal ligament was perforated and an arterial vessel was lacerated. The patient became hemodynamically unstable demanding prompt supine repositioning and cardiopulmonary resuscitation (CPR). REBOA enabled cardiovascular stabilization after 90 min of CPR and laparotomy with vascular reconstruction and contributed to the survival of the patient without major clinical deficits. The patient was discharged from the ICU after 7 days.Clinical discussionResuscitative endovascular balloon occlusion of the aorta is an emergency procedure to control life-threatening hemorrhage. REBOA should be available on-scene and applied by well-trained vascular surgery personnel to control vascular complications or extend to emergency laparotomy and thoracotomy with aortic cross-clamping in case of in-hospital non-controllable hemorrhages. In case of ongoing CPR, we recommend surgical groin incision, open puncture of the pulseless common femoral artery, and aortic balloon inflation in REBOA zone I. Hereby, fast access and CPR optimization for heart and brain perfusion are maintained.ConclusionTraining for REBOA is the decisive factor to control selected cases of in-house and outpatient massive arterial abdominal bleeding complications.
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- 2023
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9. Aspiration risk in relation to Glasgow Coma Scale score and clinical parameters in patients with severe acute alcohol intoxication: a single-centre, retrospective study
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Thomas Bruckner, Ronald Koschny, Erik Popp, Michael Conzelmann, and Anne Hoidis
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Medicine - Abstract
Objectives In alcohol intoxicated patients, the decision for or against airway protection can be challenging and is often based on the Glasgow Coma Scale (GCS). Primary aim of this study was to analyse the aspiration risk in relation to the GCS score and clinical parameters in patients with severe acute alcohol monointoxication. Secondary aim was the association between the blood alcohol level and the GCS score.Setting Single-centre, retrospective study of alcoholised patients admitted to a German intensive care unit between 2006 and 2020.Participants A total of n=411 admissions were eligible for our analysis.Clinical measures and analysis The following data were extracted: age, gender, admission time, blood alcohol level, blood glucose level, initial GCS score, GCS score at admission, vital signs, clinical signs of aspiration and airway management measures. The empirical distribution of continuous and categorical data was calculated. Binary multivariable logistic regression analysis was used to identify possible risk factors for aspiration.Results The mean age was 35 years. 72% (n=294) of the admissions were male. The blood alcohol level (mean 2.7 g/L±1.0, maximum 5.9 g/L) did not correlate with the GCS score but with the age of the patient. In univariate analysis, the aspiration risk correlated with blood alcohol level, age, GCS score, oxygen saturation, respiratory rate and blood glucose level and was significantly higher in male patients, on vomiting, and in patients requiring airway measures. Aspiration rate was 45% (n=10) in patients without vs 6% (n=3) in patients with preserved protective reflexes (p=0.0001). In the multivariate analysis, only age and GCS score were significantly associated with the risk of aspiration.Conclusion Although in this single-centre, retrospective study the aspiration rate in severe acute alcohol monointoxicated patients correlates with GCS and protective reflexes, the decision for endotracheal intubation might rather be based on the presence of different risk factors for aspiration.
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- 2021
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10. Automated mechanical cardiopulmonary resuscitation devices versus manual chest compressions in the treatment of cardiac arrest: protocol of a systematic review and meta-analysis comparing machine to human
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Katrin Jensen, Markus A Weigand, Manuel Obermaier, Johannes B Zimmermann, Erik Popp, Sebastian Weiterer, Alexander Dinse-Lambracht, Claus-Martin Muth, Benedikt L Nußbaum, Jan-Thorsten Gräsner, Stephan Seewald, and Svenja E Seide
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Medicine - Abstract
Introduction Cardiac arrest is a leading cause of death in industrialised countries. Cardiopulmonary resuscitation (CPR) guidelines follow the principles of closed chest compression as described for the first time in 1960. Mechanical CPR devices are designed to improve chest compression quality, thus considering the improvement of resuscitation outcomes. This protocol outlines a systematic review and meta-analysis methodology to assess trials investigating the therapeutic effect of automated mechanical CPR devices at the rate of return of spontaneous circulation, neurological state and secondary endpoints (including short-term and long-term survival, injuries and surrogate parameters for CPR quality) in comparison with manual chest compressions in adults with cardiac arrest.Methods and analysis A sensitive search strategy will be employed in established bibliographic databases from inception until the date of search, followed by forward and backward reference searching. We will include randomised and quasi-randomised trials in qualitative analysis thus comparing mechanical to manual CPR. Studies reporting survival outcomes will be included in quantitative analysis. Two reviewers will assess independently publications using a predefined data collection form. Standardised tools will be used for data extraction, risks of bias and quality of evidence. If enough studies are identified for meta-analysis, the measures of association will be calculated by dint of bivariate random-effects models. Statistical heterogeneity will be evaluated by I2-statistics and explored through sensitivity analysis. By comprehensive subgroup analysis we intend to identify subpopulations who may benefit from mechanical or manual CPR techniques. The reporting follows the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement.Ethics and dissemination No ethical approval will be needed because data from previous studies will be retrieved and analysed. Most resuscitation studies are conducted under an emergency exception for informed consent. This publication contains data deriving from a dissertation project. We will disseminate the results through publication in a peer-reviewed journal and at scientific conferences.PROSPERO registration number CRD42017051633.
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- 2021
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11. Feasibility of CardioSecur®, a Mobile 4-Electrode/22-Lead ECG Device, in the Prehospital Emergency Setting
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Sebastian Spaich, Hanna Kern, Thomas A. Zelniker, Jan Stiepak, Michael Gabel, Erik Popp, Hugo A. Katus, and Michael R. Preusch
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acute coronary syndrome ,electrocardiogram ,ECG ,STEMI ,myocardial infarction ,user-friendliness ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
Background: This study explores the application of CardioSecur® (CS-ECG), a hand-held 4-electrode/22-lead ECG-device, in comparison with conventional 12-lead electrocardiogram (c12L-ECG) in patients with acute chest pain in the prehospital emergency setting.Methods: CS-ECG systems were provided for two physician-staffed emergency ambulances and parallel recordings of c12L-ECG and CS-ECG were obtained from all patients with acute chest pain. Treating emergency physicians were asked to evaluate the CS-ECG system with a standardized questionnaire. Following study completion, acquired ECGs were analyzed separately by two independent cardiologists blinded to all other medical records.Results: Over a period of 20 months a total of 203 patients were included in our study. According to a standardized questionnaire, 79% of emergency medical professionals preferred application of CS-ECG, with 87% of teams judging CS-ECG to be beneficial for patients. Morover, 79% of physicians reported a reduction in time to definitive diagnosis with implementation of CS-ECG. The majority of professional users attested user-friendliness and feasibility of CS-ECG in terms of easy general handling (94%), application (93%), and placement of electrodes (98%). During prehospital triage, both c12L-ECG and CS-ECG correctly identified 31 (91%) patients with ST-elevation myocardial infarction (STEMI).Conclusion: In this first pilot study, implementation of the CardioSecur®-ECG system in the prehospital emergency setting demonstrated feasibility and user-friendliness so that emergency teams generally preferred CS-ECG to c12L-ECG. Diagnostic yield of CS-ECG was similar to c12L-ECG recordings.
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- 2020
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12. Motion and dural sac compression in the upper cervical spine during the application of a cervical collar in case of unstable craniocervical junction-A study in two new cadaveric trauma models.
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Shiyao Liao, Niko R E Schneider, Petra Hüttlin, Paul A Grützner, Frank Weilbacher, Stefan Matschke, Erik Popp, and Michael Kreinest
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Medicine ,Science - Abstract
Unstable conditions of the craniocervical junction such as atlanto-occipital dislocation (AOD) or atlanto-axial instability (AAI) are severe injuries with a high risk of tetraplegia or death. Immobilization by a cervical collar to protect the patient from secondary damage is a standard procedure in trauma patients. If the application of a cervical collar to a patient with an unstable craniocervical condition may cause segmental motion and secondary injury to the spinal cord is unknown. The aim of the current study is (i) to analyze compression on the dural sac and (ii) to determine relative motion of the cervical spine during the procedure of applying a cervical collar in case of ligamentous unstable craniocervical junction.Ligamentous AOD as well as AOD combined with ligamentous AAI was simulated in two newly developed cadaveric trauma models. Compression of the dural sac and segmental angulation in the upper cervical spine were measured on video fluoroscopy after myelography during the application of a cervical collar. Furthermore, overall three-dimensional motion of the cervical spine was measured by a motion tracking system. In six cadavers each, the two new trauma models on AOD and AOD combined with AAI could be implemented. Mean dural sac compression was significantly increased to -1.1 mm (-1.3 to -0.7 mm) in case of AOD and -1.2 mm (-1.6 to -0.6 mm) in the combined model of AOD and AAI. Furthermore, there is a significant increased angulation at the C0/C1 level in the AOD model. Immense three-dimensional movement up to 22.9° of cervical spine flexion was documented during the procedure.The current study pointed out that applying a cervical collar in general will cause immense three-dimensional movement. In case of unstable craniocervical junction, this leads to a dural sac compression and thus to possible damage to the spinal cord.
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- 2018
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13. Aktuelle Ergebnisse notfallmedizinischer Forschung – Teil 1
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Bibiana Metelmann, Stephan Katzenschlager, and Erik Popp
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General Medicine - Published
- 2022
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14. Sepsis in der prähospitalen Notfallmedizin
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Florian Uhle, Markus A. Weigand, Manuel Obermaier, and Erik Popp
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Out of hospital ,medicine.medical_specialty ,Surviving Sepsis Campaign ,Septic shock ,business.industry ,Organ dysfunction ,medicine.disease ,Sepsis ,Intensive care ,Emergency medicine ,Emergency Medicine ,medicine ,Emergency medical services ,Golden hour (medicine) ,medicine.symptom ,business - Abstract
Zusammenfassung Hintergrund Die Sepsis ist eine notfallmedizinische Herausforderung – denn diese lebensbedrohliche Organdysfunktion, verursacht durch eine dysregulierte Wirtsantwort auf eine Infektion, präsentiert sich in vielfältiger Ausprägung und wird deshalb häufig erst zu spät erkannt. Fragestellung Die kürzlich publizierten „surviving sepsis campaign“-Guidelines und die deutsche S3-Leitlinie geben Empfehlungen zur Diagnostik und Therapie der Sepsis im intrahospitalen bzw. intensivmedizinischen Setting, gehen jedoch nicht explizit auf den Bereich der prähospitalen Notfallmedizin ein. Ziel der Arbeit ist es, die Evidenzlage im Hinblick auf die prähospitale Versorgung von Patienten mit Verdacht auf Sepsis herauszuarbeiten und daraus Handlungsoptionen für den Notarzt- und Rettungsdienst abzuleiten. Diskussion Die Therapie der Sepsis und des septischen Schocks wird in Bündeln zusammengefasst, wobei das erste idealerweise innerhalb der ersten Stunde abgeschlossen sein soll – analog zum Konzept der „golden hour“ bei anderen notfallmedizinischen Entitäten wie der Traumaversorgung. Die prähospitale Therapie fokussiert sich auf die Sicherung der Vitalparameter gemäß ABCDE-Schema, wobei insbesondere der Volumentherapie ein hoher Stellenwert zukommt. Die weiteren Maßnahmen des „1 h bundle“, wie Laktatmessung, Gewinnung mikrobiologischer Proben und Beginn einer antiinfektiven Therapie, sind regelhaft erst in der Klinik möglich. Ziel ist eine schnellstmögliche Fokussanierung, wofür die Auswahl und Vorabinformation einer geeigneten Zielklinik zur Initiierung und Bahnung der weiteren klinischen Diagnostik- und Behandlungspfade, eine strukturierte und gezielte Übergabe sowie regelmäßige Fortbildung erforderlich sind.
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- 2021
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15. Nicht-invasive Beatmung in der Präklinik
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Frank Weilbacher, Niko R. E. Schneider, Felix C. F. Schmitt, Daniel Gruneberg, Erik Popp, and Markus A. Weigand
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medicine.medical_specialty ,COPD ,Cardiac decompensation ,business.industry ,Internal medicine ,Emergency Medicine ,medicine ,Cardiology ,Acute respiratory failure ,Critical Care and Intensive Care Medicine ,medicine.disease ,business - Published
- 2021
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16. Advanced and Invasive Cardiopulmonary Resuscitation (CPR) Techniques as an Adjunct to Advanced Cardiac Life Support
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Manuel Obermaier, Stephan Katzenschlager, Othmar Kofler, Frank Weilbacher, and Erik Popp
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General Medicine - Abstract
Background: Despite numerous promising innovations, the chance of survival from sudden cardiac arrest has remained virtually unchanged for decades. Recently, technological advances have been made, user-friendly portable devices have been developed, and advanced invasive procedures have been described that could improve this unsatisfactory situation. Methods: A selective literature search in the core databases with a focus on randomized controlled trials and guidelines. Results: Technical aids, such as feedback systems or automated mechanical cardiopulmonary resuscitation (CPR) devices, can improve chest compression quality. The latter, as well as extracorporeal CPR, might serve as a bridge to treatment (with extracorporeal CPR even as a bridge to recovery). Sonography may be used to improve thoracic compressions on the one hand and to rule out potentially reversible causes of cardiac arrest on the other. Resuscitative endovascular balloon occlusion of the aorta might enhance myocardial and cerebral perfusion. Minithoracostomy, pericardiocentesis, or clamshell thoracotomy might resolve reversible causes of cardiac arrest. Conclusions: It is crucial to identify those patients who may benefit from an advanced or invasive procedure and make the decision to implement the intervention in a timely manner. As with all infrequently performed procedures, sound education and regular training are paramount.
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- 2022
17. Präklinische Bluttransfusion bei lebensbedrohlicher Blutung – erweiterte lebensrettende Therapieoptionen durch das Konzept Medical Intervention Car
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Erik Popp, Niko R. E. Schneider, T. Maurer, M. A. Weigand, A. M. Würmell, Frank Weilbacher, and A. Leo
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Gynecology ,medicine.medical_specialty ,business.industry ,Emergency Medicine ,medicine ,business - Abstract
ZusammenfassungDas Medical Intervention Car (MIC) der Klinik für Anästhesiologie des Universitätsklinikums Heidelberg (UKHD) stellt ein neuartiges experimentelles Versorgungskonzept dar, welches zusätzliche Expertise und bisher nur innerklinisch etablierte Interventionen in der Präklinik verfügbar macht. Hierzu zählen die Transfusion von Blutprodukten, die Notfallthorakotomie, die „resuscitative endovascular balloon occlusion of the aorta“ (REBOA) sowie die Möglichkeit zur extrakorporalen kardiopulmonalen Reanimation (eCPR). Anhand der Fallvorstellung eines jungen Patienten, der sich mit einer Kettensäge in der Leiste verletzte und einen hämorrhagisch bedingten Kreislaufstillstand erlitt, wird insbesondere die Möglichkeit der lebensrettenden Transfusion diskutiert. In diesem Einsatz führte ein integratives präklinisches Versorgungskonzept, bestehend aus Rettungswagen, Notarzteinsatzfahrzeug und MIC, zur Wiederherstellung des Spontankreislaufs und einer vollständigen zerebralen Erholung des Patienten.
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- 2021
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18. Kritische Patientinnen und Patienten identifizieren und Ressourcen gezielt aktivieren
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Manuel Obermaier, Markus A. Weigand, Erik Popp, and Florian Uhle
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Emergency Medicine - Published
- 2023
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19. Die intramuskuläre Injektion in der Notfallmedizin
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Erik Popp, Tobias Küßner, and Manuel Obermaier
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Gynecology ,03 medical and health sciences ,medicine.medical_specialty ,0302 clinical medicine ,business.industry ,Emergency Medicine ,medicine ,030208 emergency & critical care medicine ,Critical Care and Intensive Care Medicine ,business ,030217 neurology & neurosurgery - Abstract
ZusammenfassungAuch wenn die intramuskuläre Injektion in der Notfallmedizin eher eine untergeordnete Rolle spielt, stellt sie doch einen effektiven, sicheren und schnellen Applikationsweg zur Verabreichung bestimmter Notfallmedikamente dar. So findet sie sich in verschiedenen Leitlinien als First-Line-Zugangsweg, so z. B. bei der Anaphylaxie und dem Status epilepticus. Auch bei aggressiven bzw. agitierten Patienten und Kindern bestehen gute Erfahrungen hinsichtlich der intramuskulären Verabreichung (analgo-)sedierender Medikamente. In Notfallsituationen gut zugängliche Applikationsorte sind der laterale Oberschenkel, die Wade und die Schulter. Bei sorgfältiger und antiseptischer Vorgehensweise sowie korrekter Wahl von Punktionsort und Nadellänge sind Komplikationen selten.
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- 2020
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20. 'Resuscitative endovascular balloon occlusion of the aorta' (REBOA)
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M Engelhart, Alexander Hyhlik-Dürr, Sebastian Zerwes, M. Wortmann, Erik Popp, and K. Elias
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Gynecology ,medicine.medical_specialty ,Aorta ,business.industry ,030208 emergency & critical care medicine ,030204 cardiovascular system & hematology ,medicine.disease ,Polytrauma ,03 medical and health sciences ,0302 clinical medicine ,Transplant surgery ,Cardiothoracic surgery ,Balloon occlusion ,medicine.artery ,medicine ,Surgery ,ddc:610 ,business ,Abdominal surgery - Abstract
ZusammenfassungHintergrund„Resuscitative endovascular balloon occlusion of the aorta“ (REBOA) stellt ein endovaskuläres Verfahren dar, bei dem ein Blockballon in die Aorta eingeführt wird, um eine distal des Ballons gelegene Blutung zu verringern und gleichzeitig die kardiale und zerebrale Oxygenierung zu verbessern.Ziel der ArbeitVorstellung der REBOA-Technik, der möglichen Indikationen, der benötigen Materialien und der möglichen Komplikationen des Verfahrens.Material und MethodenNichtsystematischer Übersichtsartikel über die aktuelle Literatur.ErgebnisseREBOA stellt gerade bei traumatisch bedingten Blutungen und rupturierten Aortenaneurysmen ein mögliches additives Verfahren zur hämodynamischen Stabilisierung dar. Die Komplikationsrate des Verfahrens liegt bei ungefähr 5 %, wobei Zugangskomplikationen im Vordergrund stehen, jedoch auch letale Komplikationen möglich sind.DiskussionEine aortale Ballonblockade wird bei der Versorgung rupturierter Aortenaneurysmen standardmäßig eingesetzt. Es gibt wachsende Evidenz, dass REBOA bei der Versorgung polytraumatisierter Patienten mit einem hämorrhagischen Schock aufgrund einer abdominellen oder viszeralen Blutung eine vergleichsweise minimal-invasive Alternative zur offen chirurgischen Aortenklemmung mittels Thorakotomie darstellt. Mit der Entwicklung neuer Ballonkatheter, die ohne Führungsdraht und mit geringeren Schleusendurchmessern auskommen, wird auch ein Einsatz bei anderen Krankheitsbildern wie postoperativen abdominellen Nachblutungen, gynäkologischen Blutungen oder als additives Verfahren bei der kardiopulmonalen Reanimation diskutiert.
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- 2020
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21. Atemwegsmanagement bei Verletzungen der Halswirbelsäule
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Frank Weilbacher, Manuel Obermaier, Niko R. E. Schneider, and Erik Popp
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Gynecology ,medicine.medical_specialty ,medicine.diagnostic_test ,business.industry ,medicine.medical_treatment ,010102 general mathematics ,Laryngoscopy ,030208 emergency & critical care medicine ,Critical Care and Intensive Care Medicine ,medicine.disease ,01 natural sciences ,Cervical spine ,03 medical and health sciences ,0302 clinical medicine ,Trauma management ,Emergency Medicine ,medicine ,Intubation ,Airway management ,0101 mathematics ,business ,Spinal cord injury - Abstract
ZusammenfassungDas Atemwegsmanagement bei Trauma der Halswirbelsäule ist eine Herausforderung: Der vital bedrohte Patient soll eine suffiziente Immobilisation erhalten, wodurch aber die Atemwegssicherung erschwert wird. Der Beitrag thematisiert den Stellenwert von Immobilisierung und Atemwegssicherung in dieser zeitkritischen Situation, Vorteile und Fallstricke verschiedener Atemwegshilfsmittel sowie die pathoanatomischen und pathophysiologischen Hintergründe.
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- 2020
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22. Developments in Post-Resuscitation Care for Out-of-Hospital Cardiac Arrests in Adults—A Narrative Review
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Stephan Katzenschlager, Erik Popp, Jan Wnent, Markus A. Weigand, and Jan-Thorsten Gräsner
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General Medicine - Abstract
This review focuses on current developments in post-resuscitation care for adults with an out-of-hospital cardiac arrest (OHCA). As the incidence of OHCA is high and with a low percentage of survival, it remains a challenge to treat those who survive the initial phase and regain spontaneous circulation. Early titration of oxygen in the out-of-hospital phase is not associated with increased survival and should be avoided. Once the patient is admitted, the oxygen fraction can be reduced. To maintain an adequate blood pressure and urine output, noradrenaline is the preferred agent over adrenaline. A higher blood pressure target is not associated with higher rates of good neurological survival. Early neuro-prognostication remains a challenge, and prognostication bundles should be used. Established bundles could be extended by novel biomarkers and methods in the upcoming years. Whole blood transcriptome analysis has shown to reliably predict neurological survival in two feasibility studies. This needs further investigation in larger cohorts.
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- 2023
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23. Evaluation der Aufnahmekriterien von Patienten nach Verkehrsunfall in den Schockraum
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Gerhard Schmidmaier, J. C. Stephan, L. M. Stephan-Paulsen, M. A. Weigand, Erik Popp, and T. Grossner
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Gynecology ,03 medical and health sciences ,medicine.medical_specialty ,0302 clinical medicine ,business.industry ,Emergency Medicine ,medicine ,030208 emergency & critical care medicine ,030212 general & internal medicine ,business - Abstract
Zusammenfassung Hintergrund Die aktuelle S3-Leitlinie Polytrauma/Schwerverletzten-Behandlung der Deutschen Gesellschaft für Unfallchirurgie (DGU) empfiehlt bei einem Pkw-Unfall mit einer Geschwindigkeitsveränderung von delta >30 km/h die Versorgung in einem Schockraum ohne Berücksichtigung der Verletzungen des Patienten. Ziel dieser Studie war es zu untersuchen, ob Patienten, die ausschließlich aufgrund dieses Kriteriums über einen Schockraum aufgenommen wurden, relevante Verletzungen aufwiesen, die intensivmedizinische Behandlungen oder (Not‑)Operationen benötigten. Methode Nach einem Pkw-Unfall wurden Patienten ohne spezifische Verletzung, bei denen ausschließlich eine Geschwindigkeitsveränderung von delta >30 km/h vorlag (Empfehlungsgrad B der S3-Leitlinie), der Studiengruppe, Patienten mit Verletzungen gem. Empfehlungsgrad A der Leitlinie der Vergleichsgruppe zugeordnet. Ein schockraumrelevantes Trauma wurde als Injury Severity Score (ISS) ≥16, operative Versorgung innerhalb 24 h, intensivmedizinische Überwachung >24 h, Versterben während des Krankenhausaufenthalts sowie DGU-Basiskollektiv (MAIS3+ oder MAIS2 mit Intensivverweildauer >24 h bzw. Versterben während des Krankenhausaufenthalts) definiert. Ergebnisse Der Vergleich zeigte einen hochsignifikanten Unterschied in Bezug auf den mittleren ISS (p ≤ 0,001), ein schockraumrelevantes Trauma (ISS ≥16; p ≤ 0,001), eine intensivmedizinische Versorgung >24 h (p ≤ 0,001), Operation innerhalb von 24 h nach Krankenhausaufnahme (p ≤ 0,001), Letalität (p ≤ 0,001) sowie DGU-Basiskollektiv (p ≤ 0,001). Anhand dieser Ergebnisse konnte gezeigt werden, dass innerhalb der Studiengruppe (Geschwindigkeitsveränderung von delta >30 km/h; Empfehlungsgrad B der S3-Leitlinie) lediglich ein Patient eine Traumafolge aufwies, die eine intensivmedizinische Behandlung >24 h oder eine Operation nötig machte. Studien- und Vergleichsgruppen waren in Bezug auf das mittlere Alter (p = 1,778), das männliche Geschlecht (p = 0,1728) sowie die durchschnittliche Unfallgeschwindigkeit (p = 0,4606) vergleichbar. Diskussion Ein alleiniges Vorliegen eines Pkw-Unfalls mit einer Geschwindigkeitsveränderung von delta >30 km/h kann nicht als adäquater Prädiktor für ein schockraumrelevantes Trauma gesehen werden. Weitere Studien könnten durch eine Leitlinienanpassung eine weiterhin sichere und hochwertige Patientenversorgung bei Reduktion von personellen und finanziellen Belastungen ermöglichen.
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- 2020
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24. Clamshell-Thorakotomie nach singulärem Messerstich in die 'cardiac box'
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Christine Leowardi, Bastian Schmack, Oliver Lutz, Angelika Kühn, and Erik Popp
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Pulmonary and Respiratory Medicine ,Gynecology ,medicine.medical_specialty ,Cardiothoracic surgery ,business.industry ,medicine ,Surgery ,Cardiology and Cardiovascular Medicine ,business - Abstract
Zusammenfassung Fallberichte zur präklinischen Durchführung einer Clamshell-Thorakotomie in Deutschland sind bisher rar, wenngleich diese Notfallprozedur in internationalen Leitlinien zur Behandlung des traumatischen Kreislaufstillstands enthalten ist. Im vorliegenden Beitrag wird die Versorgung eines erwachsenen Patienten nach einem Messerstich in den als „cardiac box“ bezeichneten Bereich des Thorax dargestellt. Konventionelle Maßnahmen der kardiopulmonalen Reanimation wie Atemwegssicherung, Beatmung und Thoraxkompression führten nicht zur Wiederherstellung des Kreislaufs („return of spontaneous circulation“, ROSC). Nachdem auch nach Ausschluss eines Spannungspneumothorax mithilfe einer Minithorakotomie kein dauerhafter ROSC erzeugt werden konnte, wurde entsprechend der Leitlinienempfehlung eine Thorakotomie erwogen und vor Ort durchgeführt. Nach dem Ausräumen einer Perikardtamponade und anschließendem ROSC wurde eine stark blutende Myokardverletzung übernäht und der Patient in den Schockraum des Universitätsklinikum Heidelberg gebracht. Dort erfolgten eine Notfalltransfusion und konsekutiv die definitive Versorgung der Verletzung im kardiochirurgischen OP. Der Patient verstarb am Folgetag an den Folgen eines hypoxischen Hirnödems im Beisein seiner Angehörigen.
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- 2019
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25. Konventionelle Intubation und Larynxtubus bei Halswirbelsäuleninstabilität
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Michael Kreinest, Frank Weilbacher, M. Münzberg, M. A. Weigand, S. Liao, Niko R. E. Schneider, and Erik Popp
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Gynecology ,medicine.medical_specialty ,Atlanto-occipital dislocation ,Anesthesiology and Pain Medicine ,business.industry ,Atlanto axial instability ,medicine ,General Medicine ,medicine.disease ,business - Abstract
Beim Atemwegsmanagement von Patienten mit instabiler Verletzung der Halswirbelsaule gilt es, iatrogene Schadigungen zu vermeiden, die optimale Methode bleibt bisher jedoch offen. Ziel der Studie war es, mogliche Unterschiede bezuglich der Kompression des Duralsacks zwischen konventioneller Intubation und dem Larynxtubus LTS-D im unfixierten Humanpraparat zu untersuchen. Die orotracheale Intubation mittels konventionellem Macintosh-Laryngoskop und die Einlage des LTS-D wurden an 6 unfixierten humanen Leichen unter Myelographie durchgefuhrt. Jede Intervention erfolgte zunachst 3‑mal an der intakten Halswirbelsaule (HWS), sodann erneut bei Vorliegen einer chirurgisch erzeugten kombinierten atlantookzipitalen Dislokation (AOD) und atlantoaxialen Instabilitat (AAI). Primar wurden Anderungen der Duralsackweite auf Hohe der Cervicalwirbel (C) 0 (Schadelbasis) und 1 sowie 1 und 2 erfasst. Die Intubationsmethoden wurden als unabhangig betrachtet und die Unterschiede nach Mann-Whitney untersucht. Bei intakter Wirbelsaule war auf Hohe C0/C1 die Anderung der Duralsackweite wahrend konventioneller Laryngoskopie geringer als wahrend der Einlage des Larynxtubus (0,33 vs. 0,46 mm, p = 0,035). Bei gleichzeitiger AOD und AAI allerdings zeigte sich bei der konventionellen endotrachealen Intubation eine starkere Reduktion der Duralsackweite als bei Einlage des Larynxtubus (1,18 vs. 0,68 mm, p = 0,005). Auf Hohe C1/C2 fanden sich weder bei intakter HWS noch bei kombinierter AAI und AOD Unterschiede zwischen konventioneller Intubation und Larynxtubus. Am unfixierten humanen Leichenmodell mit kombinierter AOD/AAI fuhrte die Einlage des LTS-D zu geringerer Anderung der Duralsackweite auf Hohe des kraniozervikalen Ubergangs als die konventionelle Intubation und konnte somit auch am Lebenden vorteilhaft sein.
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- 2019
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26. Clamshell-Thorakotomie im Rettungsdienst und Schockraum: Indikationen, Anforderungen und Technik
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Niko R. E. Schneider, Marcus Rudolph, Tim Lange, Martin Göring, and Erik Popp
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Gynecology ,03 medical and health sciences ,medicine.medical_specialty ,0302 clinical medicine ,business.industry ,010102 general mathematics ,Emergency Medicine ,medicine ,030208 emergency & critical care medicine ,0101 mathematics ,Critical Care and Intensive Care Medicine ,business ,01 natural sciences - Abstract
ZusammenfassungDie Notfallthorakotomie beim traumatischen Herz-Kreislauf-Stillstand spielte in Deutschland lange Zeit eine untergeordnete Rolle. Nach der Veröffentlichung der Reanimationsleitlinien des ERCs 2015 rückte der Algorithmus zur Versorgung dieses Verletzungsmusters in den Mittelpunkt, und speziell die Notfallthorakotomie war Auslöser einiger kontroverser Diskussionen. Die vorliegende Arbeit beschreibt nun die Indikationen für eine Thorakotomie im Rahmen einer Reanimation und erläutert die nötigen Rahmenbedingungen. Weiterhin wird die Technik Schritt für Schritt beschrieben. Darüber hinaus erfolgt eine kritische Betrachtung der Implementierung der Technik in unser Rettungsdienstsystem sowie der Hinweis auf bestehende Schulungskonzepte.
- Published
- 2019
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27. [Sepsis in out-of-hospital emergency medicine]
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Manuel, Obermaier, Markus A, Weigand, Erik, Popp, and Florian, Uhle
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Emergency medical services ,Focus ,Übersicht ,Infektion ,Septic shock ,Septischer Schock ,Antiinfektiva ,Rettungsdienst ,Antiinfectives ,Fokus ,Infections - Abstract
Hintergrund Die Sepsis ist eine notfallmedizinische Herausforderung – denn diese lebensbedrohliche Organdysfunktion, verursacht durch eine dysregulierte Wirtsantwort auf eine Infektion, präsentiert sich in vielfältiger Ausprägung und wird deshalb häufig erst zu spät erkannt. Fragestellung Die kürzlich publizierten „surviving sepsis campaign“-Guidelines und die deutsche S3-Leitlinie geben Empfehlungen zur Diagnostik und Therapie der Sepsis im intrahospitalen bzw. intensivmedizinischen Setting, gehen jedoch nicht explizit auf den Bereich der prähospitalen Notfallmedizin ein. Ziel der Arbeit ist es, die Evidenzlage im Hinblick auf die prähospitale Versorgung von Patienten mit Verdacht auf Sepsis herauszuarbeiten und daraus Handlungsoptionen für den Notarzt- und Rettungsdienst abzuleiten. Diskussion Die Therapie der Sepsis und des septischen Schocks wird in Bündeln zusammengefasst, wobei das erste idealerweise innerhalb der ersten Stunde abgeschlossen sein soll – analog zum Konzept der „golden hour“ bei anderen notfallmedizinischen Entitäten wie der Traumaversorgung. Die prähospitale Therapie fokussiert sich auf die Sicherung der Vitalparameter gemäß ABCDE-Schema, wobei insbesondere der Volumentherapie ein hoher Stellenwert zukommt. Die weiteren Maßnahmen des „1 h bundle“, wie Laktatmessung, Gewinnung mikrobiologischer Proben und Beginn einer antiinfektiven Therapie, sind regelhaft erst in der Klinik möglich. Ziel ist eine schnellstmögliche Fokussanierung, wofür die Auswahl und Vorabinformation einer geeigneten Zielklinik zur Initiierung und Bahnung der weiteren klinischen Diagnostik- und Behandlungspfade, eine strukturierte und gezielte Übergabe sowie regelmäßige Fortbildung erforderlich sind.
- Published
- 2021
28. Positron Emission Tomography Imaging of Long-Term Expression of the 18 kDa Translocator Protein After Sudden Cardiac Arrest in Rats
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Thorsten Annecke, Daniel C. Schroeder, Stefanie Vus, Bernd Neumaier, David de la Puente Bethencourt, Heike Endepols, Tim Hucho, Boris D. Zlatopolskiy, Simon R Finke, Johannes Zischler, Holger Herff, Alexander Drzezga, Erik Popp, Cathrin Rohleder, and Bernd W. Böttiger
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Male ,medicine.medical_specialty ,Time Factors ,030204 cardiovascular system & hematology ,Hippocampal formation ,Critical Care and Intensive Care Medicine ,Rats, Sprague-Dawley ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,Acetamides ,medicine ,Translocator protein ,Animals ,Neuroinflammation ,medicine.diagnostic_test ,biology ,business.industry ,Phenyl Ethers ,030208 emergency & critical care medicine ,Magnetic resonance imaging ,Sudden cardiac arrest ,medicine.disease ,Receptors, GABA-A ,Barnes maze ,Heart Arrest ,Rats ,Positron emission tomography ,Positron-Emission Tomography ,Ventricular fibrillation ,Emergency Medicine ,Cardiology ,biology.protein ,medicine.symptom ,business ,Carrier Proteins - Abstract
Background Knowledge about the neuroinflammatory state during months after sudden cardiac arrest is scarce. Neuroinflammation is mediated by cells that express the 18 kDa translocator protein (TSPO). We determined the time course of TSPO-expressing cells in a rat model of sudden cardiac arrest using longitudinal in vivo positron emission tomography (PET) imaging with the TSPO-specific tracer [18F]DAA1106 over a period of 6 months. Methods Five male Sprague Dawley rats were resuscitated from 6 min sudden cardiac arrest due to ventricular fibrillation, three animals served as shams. PET measurements were performed on day 5, 8, 14, 90, and 180 after intervention. Magnetic resonance imaging was performed on day 140. Imaging was preceded by Barnes Maze spatial memory testing on day 3, 13, 90, and 180. Specificity of [18F]DAA1106 binding was confirmed by Iba-1 immunohistochemistry. Results [18F]DAA1106 accumulated bilaterally in the dorsal hippocampus of all sudden cardiac arrest animals on all measured time points. Immunohistochemistry confirmed Iba-1 expressing cells in the hippocampal CA1 region. The number of Iba-1-immunoreactive objects per mm2 was significantly correlated with [18F]DAA1106 uptake. Additionally, two of the five sudden cardiac arrest rats showed bilateral TSPO-expression in the striatum that persisted until day 180. In Barnes Maze, the relative time spent in the target quadrant negatively correlates with dorsal hippocampal [18F]DAA1106 uptake on day 14 and 180. Conclusions After sudden cardiac arrest, TSPO remains expressed over the long-term. Sustainable treatment options for neuroinflammation may be considered to improve cognitive functions after sudden cardiac arrest.
- Published
- 2020
29. Non-Invasive Ventilation as a Therapy Option for Acute Exacerbations of Chronic Obstructive Pulmonary Disease and Acute Cardiopulmonary Oedema in Emergency Medical Services
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Felix C. F. Schmitt, Daniel Gruneberg, Niko R. E. Schneider, Jan-Ole Fögeling, Moritz Leucht, Felix Herth, Michael R. Preusch, Werner Schmidt, Christian Bopp, Thomas Bruckner, Markus A. Weigand, Stefan Hofer, and Erik Popp
- Subjects
prehospital non-invasive ventilation ,acute respiratory insufficiency ,acute cardiopulmonary oedema ,acute exacerbated COPD ,emergency medical service ,General Medicine - Abstract
In this observational prospective multicenter study conducted between October 2016 and October 2018, we tested the hypothesis that the use of prehospital non-invasive ventilation (phNIV) to treat patients with acute respiratory insufficiency (ARI) caused by severe acute exacerbations of chronic obstructive pulmonary disease (AECOPD) and acute cardiopulmonary oedema (ACPE) is effective, time-efficient and safe. The data were collected at four different physician response units and three admitting hospitals in a German EMS system. Patients with respiratory failure due to acute exacerbation of chronic obstructive pulmonary disease and acute cardiopulmonary oedema were enrolled. A total of 545 patients were eligible for the final analysis. Patients were treated with oxygen supplementation, non-invasive ventilation or invasive mechanical ventilation. The primary outcomes were defined as changes in the clinical parameters and the in-hospital course. The secondary outcomes included time efficiency, peri-interventional complications, treatment failure rate, and side-effects. Oxygenation under phNIV improved equally to endotracheal intubation (ETI), and more effectively in comparison to standard oxygen therapy (SOT) (paO2 SOT vs. non-invasive ventilation (NIV) vs. ETI: 82 mmHg vs. 125 mmHg vs. 135 mmHg, p-value SOT vs. NIV < 0.0001). In a matched subgroup analysis phNIV was accompanied by a reduced time of mechanical ventilation (phNIV: 1.8 d vs. ETI: 4.2 d) and a shortened length of stay at the intensive care unit (3.4 d vs. 5.8 d). The data support the hypothesis that the treatment of severe AECOPD/ACPE-induced ARI using prehospital NIV is effective, time efficient and safe. Compared to ETI, a matched comparison supports the hypothesis that prehospital implementation of NIV may provide benefits for an in-hospital course.
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- 2022
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30. Invasive Notfalltechniken – INTECH Advanced
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Niko R. E. Schneider, Erik Popp, Martin Göring, M. Rudolph, Frank Weilbacher, T. Küßner, and Stefan Mohr
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Gynecology ,03 medical and health sciences ,medicine.medical_specialty ,0302 clinical medicine ,business.industry ,Emergency Medicine ,medicine ,030208 emergency & critical care medicine ,030204 cardiovascular system & hematology ,business - Abstract
Invasive Notfalltechniken konnen in bestimmten Situationen lebensrettend sein, sind allerdings selten indiziert, sodass seitens des Rettungsdienst- bzw. Klinikpersonals keine Erfahrung besteht. Entsprechend wird gefordert, diese Masnahmen in praxisnahen Kurssystemen zu vermitteln und zu trainieren, um sie in der Notfallsituation adaquat anwenden zu konnen. Beim Heidelberger Kurskonzept INTECH Advanced stehen die invasiven Notfalltechniken „resuscitative endovascular balloon occlusion of the aorta“ (REBOA), Perikardiozentese und Clamshell-Thorakotomie im Mittelpunkt. Diese Verfahren haben kurzlich Eingang in die entsprechenden nationalen und internationalen Leitlinien gefunden. Bei der REBOA wird ein Ballonkatheter uber die Leistenarterie eingefuhrt, in der Aorta descendens platziert und dort geblockt. So kann einerseits der proximale Aortendruck erhoht werden, was eine verbesserte Versorgung von Herz, Lunge und Gehirn bedingt. Andererseits lassen sich distal gelegene Blutungen reduzieren bzw. ausschalten. Die sonographiegesteuerte Perikardiozentese dient der Entlastung von hamodynamisch relevanten serosen Perikardtamponaden, um den Patienten zu stabilisieren und die Zeit bis zur operativen Versorgung zu uberbrucken. Traumatisch bedingte, blutige Perikardtamponaden sind hingegen eine Domane der Notfallthorakotomie. Hier stellt die Clamshell-Thorakotomie eine relativ einfach zu erlernende Methode dar, die eine gute Ubersicht bietet und eine Vielzahl an Interventionen erlaubt. Im Vordergrund stehen die offene Entlastung einer blutigen Perikardtamponade sowie die manuelle Kompression der Aorta descendens mit den oben genannten Effekten.
- Published
- 2018
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31. One Minute Wonder
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Manuel Obermaier, Markus A. Weigand, Erik Popp, and Florian Uhle
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Emergency Medicine - Published
- 2022
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32. Effects of combined helium pre/post-conditioning on the brain and heart in a rat resuscitation model
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C. J. Zuurbier, Benedikt Preckel, Erik Popp, Nina C. Weber, M. W. Hollmann, Jürgen Knapp, K. Stefan, Roland Galmbacher, C. J. Aehling, APH - Quality of Care, Anesthesiology, ACS - Amsterdam Cardiovascular Sciences, ACS - Heart failure & arrhythmias, ACS - Diabetes & metabolism, ACS - Atherosclerosis & ischemic syndromes, and ACS - Microcirculation
- Subjects
Male ,0301 basic medicine ,Resuscitation ,Caveolin 3 ,medicine.medical_treatment ,Caveolin 1 ,Apoptosis ,Hippocampal formation ,Helium ,Neuroprotection ,Andrology ,03 medical and health sciences ,symbols.namesake ,0302 clinical medicine ,medicine ,Animals ,Cardiopulmonary resuscitation ,Rats, Wistar ,610 Medicine & health ,TUNEL assay ,business.industry ,Brain ,Heart ,General Medicine ,medicine.disease ,Cardiopulmonary Resuscitation ,Heart Arrest ,Rats ,Neuroprotective Agents ,030104 developmental biology ,Anesthesiology and Pain Medicine ,Anesthesia ,Blood Circulation ,Ventricular fibrillation ,Nissl body ,symbols ,business ,030217 neurology & neurosurgery - Abstract
BackgroundThe noble gas helium induces cardio- and neuroprotection by pre- and post-conditioning. We investigated the effects of helium pre- and post-conditioning on the brain and heart in a rat resuscitation model. MethodsAfter approval by the Animal Care Committee, 96 Wistar rats underwent cardiac arrest for 6min induced by ventricular fibrillation. Animals received 70% helium and 30% oxygen for 5min before cardiac arrest and for 30min after restoration of spontaneous circulation (ROSC). Control animals received 70% nitrogen and 30% oxygen. Hearts and brains were excised after 2, 4h or 7days. Neurological degeneration was evaluated using TUNEL and Nissl staining in the hippocampal CA-1 sector. Cognitive function after 7days was detected with the tape removal test. Molecular targets were measured by infrared western blot. Data are shown as median [Interquartile range]. ResultsHelium treatment resulted in significantly less apoptosis (TUNEL positive cells/100 pixel 73.5 [60.3-78.6] vs.78.2 [70.4-92.9] P=0.023). Changes in Caveolin-3 expression in the membrane fraction and Hexokinase-II in the mitochondrial fraction were observed in the heart. Caveolin-1 expression of treated animals significantly differed from control animals in the membrane fraction of the heart and brain after ROSC. ConclusionTreatment with helium reduced apoptosis in our resuscitation model. Differential expression levels of Caveolin-1, Caveolin-3 and Hexokinase II in the heart were found after helium pre- and post-conditioning. No beneficial effects were seen on neurofunctional outcome
- Published
- 2017
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33. RNA origami: design, simulation and application
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Erik Poppleton, Niklas Urbanek, Taniya Chakraborty, Alessandra Griffo, Luca Monari, and Kerstin Göpfrich
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rna origami ,rna nanotechnology ,dna origami ,co-transcriptional folding ,rna nanostructures ,genetic encoding ,computational design ,molecular simulation ,Genetics ,QH426-470 - Abstract
Design strategies for DNA and RNA nanostructures have developed along parallel lines for the past 30 years, from small structural motifs derived from biology to large ‘origami’ structures with thousands to tens of thousands of bases. With the recent publication of numerous RNA origami structures and improved design methods-even permitting co-transcriptional folding of kilobase-sized structures – the RNA nanotechnolgy field is at an inflection point. Here, we review the key achievements which inspired and enabled RNA origami design and draw comparisons with the development and applications of DNA origami structures. We further present the available computational tools for the design and the simulation, which will be key to the growth of the RNA origami community. Finally, we portray the transition from RNA origami structure to function. Several functional RNA origami structures exist already, their expression in cells has been demonstrated and first applications in cell biology have already been realized. Overall, we foresee that the fast-paced RNA origami field will provide new molecular hardware for biophysics, synthetic biology and biomedicine, complementing the DNA origami toolbox.
- Published
- 2023
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34. Clamshell-Thorakotomie nach thorakalen Messerstichen
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Marcus Rudolph, Niko R. E. Schneider, and Erik Popp
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medicine.medical_specialty ,Resuscitation ,business.industry ,medicine.medical_treatment ,Treatment outcome ,Herz kreislauf stillstand ,Traumatic cardiac arrest ,030208 emergency & critical care medicine ,Hand surgery ,030204 cardiovascular system & hematology ,medicine.disease ,Knife wound ,Tension pneumothorax ,03 medical and health sciences ,0302 clinical medicine ,Emergency Medicine ,medicine ,Orthopedics and Sports Medicine ,Surgery ,Thoracotomy ,Intensive care medicine ,business - Abstract
Resuscitation in the event of traumatic cardiac arrest was for a long time considered to be a less than promising technique to employ; however, current data indicate that the prospects of success need not be any poorer than for resuscitation due to cardiac distress. The targeted and rapid remedying of reversible causes can re-establish the circulatory function and the European Resuscitation Council (ERC) algorithm for traumatic cardiac arrest is a helpful guide in this respect. This case report illustrates the resolute implementation of this algorithm in the prehospital environment in the case of an attempted suicide by a thoracic knife wound.
- Published
- 2017
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35. EuReCa ONE27 Nations, ONE Europe, ONE Registry
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Jan-Thorsten Gräsner, Rolf Lefering, Rudolph W. Koster, Siobhán Masterson, Bernd W. Böttiger, Johan Herlitz, Jan Wnent, Ingvild B.M. Tjelmeland, Fernando Rosell Ortiz, Holger Maurer, Michael Baubin, Pierre Mols, Irzal HadžibegoviĿ, Marios Ioannides, Roman Škulec, Mads Wissenberg, Ari Salo, Hervé Hubert, Nikolaos I. Nikolaou, Gerda Lóczi, Hildigunnur Svavarsdóttir, Federico Semeraro, Peter J. Wright, Carlo Clarens, Ruud Pijls, Grzegorz Cebula, Vitor Gouveia Correia, Diana Cimpoesu, Violetta Raffay, Stefan Trenkler, Andrej Markota, Anneli Strömsöe, Roman Burkart, Gavin D. Perkins, Leo L. Bossaert, Marc Kaufmann, Markus Thaler, Martin Maier, Gerhard Prause, Helmut Trimmel, Diane de Longueville, Thierry Preseau, Dominique Biarent, Christian Melot, Nicolas Mpotos, Koen Monsieurs, Patrick Van de Voorde, Marie Vanhove, Pascale Lievens, Mathias Faniel, Slobodanka Keleuva, Milan Lazarevic, Radmila Majhen Ujevic, Mato Devcic, Branka Bardak, Fabijan Barisic, Silvija Hunyadi Anticevic, Marios Georgiou, Anatolij Truhláſ, Jiſí Knor, Eva Smržová, Roman Sviták, Robin Šín, Petr Mokrejš, Freddy K. Lippert, Juhana Hallikainen, Marko Hoikka, Timo Iirola, Timo Jama, Helena Jäntti, Raimo Jokisalo, Milla Jousi, Hetti Kirves, Markku Kuisma, Jukka Laine, Sami Länkimäki, Petri Loikas, Vesa Lund, Teuvo Määttä, Heini Nal, Heimo Niemelä, Petra Portaankorva, Marko Pylkkänen, Marko Sainio, Piritta Setälä, Jerry Tervo, Taneli Väyrynen, Davy Murgue, Anne Champenois, Marc Fournier, Daniel Meyran, Romain Tabary, Aurélie Avondo, Gelin Gelin, Bruno Simonnet, Marc Joly, Isabelle Megy-Michoux, Xavier Paringaux, Yves Duffait, Michael Vial, Julien Segard, Sophie Narcisse, David Hamban, Jonathan Hennache, Sylvain Thiriez, Mathieu Doukhan, Carine Vanderstraeten, Jean-Charles Morel, Gilles Majour, Corinne Michenet, Laurent Tritsch, Marc Dubesset, Olivier Peguet, David Pinero, Fréderic Guillaumee, Patrick Fuster, Jean-François Ciacala, Benoît Jardel, Jean-Yves Letarnec, Frank Goes, Pierre Gosset, Muriel Vergne, Christian Bar, Fabienne Branche, Stevens Prineau, Steven Lagadec, Carole Cornaglia, Cécile Ursat, Philippe Bertrand, Jean-Marc Agostinucci, Pierre Nadiras, Géraldine Gonzales de Linares, Line Jacob, François Revaux, Thomas Pernot, Nathalie Roudiak, Agnès Ricard-Hibon, Laurent Villain-Coquet, Stefan Beckers, Thomas Hanff, Bernd Strickmann, Nicolai Wiegand, Petra Wilke, Harald Sues, Stefan Bogatzki, Wolfgang Baumeier, Kai Pohl, Bert Werner, Hans Fischer, Torsten Zeng, Erik Popp, Andreas Günther, Andreas Hochberg, Alex Lechleuthner, Jens-Christian Schewe, Hans Lemke, Erich Wranze-Bielefeld, Andreas Bohn, Markus Roessler, Frank Naujoks, Frank Sensen, Torben Esser, Matthias Fischer, Martin Messelken, Christopher Rose, Gabriele Schlüter, Wolfgang Lotz, Michael Corzilius, Claus-Martin Muth, Christian Diepenseifen, Björn Tauchmann, Torsten Birkholz, Andreas Flemming, Stefanie Herrmann, Uwe Kreimeier, Clemens Kill, Frank Marx, Ralph Schröder, Wolfgang Lenz, Glykeria Botini, Barakos Grigorios, Nikolaos Giannakoudakis, Michail Zervopoulos, Dimitrios Papangelis, Sofia Petropoulou-Papanastasiou, Themistoklis Liaskos, Spyridon Papanikolaou, Andreas Karabinis, Attila Zentay, Hólmgeir ÿorsteinsson, Anna Gilsdóttir, Svavar A. Birgisson, Fjölnir Freyr Guðmundsson, Hallgrímur Hreiðarsson, Björgvin ÿrnason, Hermann Hermannsson, Gísli Björnsson, Brynjar ÿór Friðriksson, Gunnar Baldursson, ÿrmann Höskuldsson, Jórunn Valgarðsdottir, Matthildur ÿsmundardóttir, Guðmundur Guðmundsson, Hjörtur Kristjánsson, Eyþór Rúnar ÿórarinsson, Jón Guðlaugsson, Sigurður Skarphéðinsson, Alberto Peratoner, Andrea Santarelli, Cesare Sabetta, Giovanni Gordini, Giovanni Sesana, Riccardo Giudici, Simone Savastano, Tommaso Pellis, Jean Beissel, Jean Uhrig, Tom Manderscheid, Marco Klop, Pascal Stammet, Marc Koch, Philippe Welter, Robert Schuman, Wendy Bruins, Hesam Amin, Nina Braa, Staale Bratland, Eirik Alnes Buanes, Tomas Draegni, Knut Roar Johnsen, Wenche Torunn Mathisen, Terje Oedegaarden, Marie Oppedal, Alf Stolt-Nielsen Reksten, Mats Eirik Roedsand, Jon Erik Steen-Hansen, Marta Dyrda, Anna Frejlich, Sſawomir MaciĿg, Sonia Osadnik, Ireneusz Weryk, Eugénio Mendonça, Carlos Freitas, Pinto Cruz, Carmo Caldeira, José Barros, Luis Vale, António Brazão, Nuno Jardim, Fernanda Rocha, Ricardo Duarte, Nicodemos Fernandes, Pedro Ramos, Margarida Jardim, Miguel Reis, Romulo Ribeiro, Sérgio Zenha, Jorge Fernandes, Juan Francisco, David Assis, Fernanda Abreu, Dinarte Freitas, Leonardo Ribeiro, Paulo Azevedo, Débora Calafatinho, Rui Jardim, Aleixo Pestana, Rui Faria, Bogdan Oprita, Alis Grasu, Paul Nedelea, Sorina Sovar, Florin Agapi, Aleksandar KliĿkoviĿ, Aleksandra LaziĿ, Bogdan NikoliĿ, Bogdan Zivanovic, Branislav MartinoviĿ, Dušan MilenkoviĿ, HuseinoviĿ Damir, Jovanka Koprivica, Kornelija Horvat JakšiĿ, Margit Pajor, Saša MiliĿ, Mirko VidoviĿ, Radojka Petrovic Glamoclija, Sladjana Andjelic, Vlajovic Sladjana, Zlatko BabiĿ, Zlatko Fišer, Peter Androvic, Lubica Bajerovska, Miroslav Chabron, Viliam Dobias, Eva Havlikova, Bozena Horanova, Renata Kratochvilova, Dana Kubova, Jan Murgas, Juraj Patras, Ladislav Simak, Vladimir Snarskij, Zuzana Zaviaticova, Marcela Zuffova, Francesc Escalada Roig, Luis Sánchez Santos, Alfredo Echarri Sucunza, Juan A. Cordero Torres, Guadalupe Inza Muñoz, Marta Martínez del Valle, Isabel Ceniceros Rozalen, Enrique Martín Sánchez, María Victoria Raúl Canabal Berlanga, Karlos Ibarguren Olalde, José I. Ruiz Azpiazu, María José García-Ochoa, Rafael Zoyo López-Navarro, José M. Adsuar Quesada, José A. Cortés Ramas, Francisco J. Mellado Vergel, Juan B. López Messa, Patricia Fernández del Valle, Luciano Anselmi, Breganzona Claudio Benvenuti, Nigel Batey, Yorkshire Ambulance, Scott Booth, Patricia Bucher, Charles D. Deakin, Jay Duckett, Chen Ji, Nancy Loughlin, Jenny Lumley-Holmes, Jessica Lynde, Frank Mersom, Carly Ramsey, Clare Robinson, Robert Spaight, Sukhdeep Dosanjh, Gurkamal Virdi, and Andrew Whittington
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medicine.medical_specialty ,resuscitation outcomes ,resuscitation ,united-states ,education ,cardiac arrest ,030204 cardiovascular system & hematology ,Emergency Nursing ,survival ,Out of hospital cardiac arrest ,resuscitation registry ,03 medical and health sciences ,0302 clinical medicine ,Epidemiology ,medicine ,cpr ,success ,business.industry ,sweden ,Incidence (epidemiology) ,association ,emergency medicine, europe ,030208 emergency & critical care medicine ,defibrillation ,3. Good health ,quality ,Emergency ,Emergency medicine ,Emergency Medicine ,epidemiology ,Cardiology and Cardiovascular Medicine ,business ,management - Abstract
INTRODUCTION: The aim of the EuReCa ONE study was to determine the incidence, process, and outcome for out of hospital cardiac arrest (OHCA) throughout Europe.METHODS: This was an international, pr ...
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- 2016
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36. Narkose im Rettungsdienst – Darauf kommt es an
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Daniela Erhard and Erik Popp
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General Engineering - Abstract
Bei einer Narkose gilt: Schon kleine Fehler konnen das Leben des Patienten gefahrden. Das ist unter den Bedingungen im Rettungsdienst noch starker der Fall als in der Klinik. Daher muss jeder Handgriff sitzen – und jeder im Team wissen, was er zu tun hat. Erik Popp, Mitautor der Leitlinie „Praklinische Notfallnarkose“ erklart im Interview, wie eine Narkose im Rettungsdienst ablauft und was Sie dabei unbedingt beachten mussen.
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- 2016
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37. Effect of Superficial Cervical Plexus Block on Baroreceptor Sensitivity in Patients Undergoing Carotid Endarterectomy
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Dittmar Böckler, Erik Popp, S. Demirel, Eike Martin, Juan Antonio Celi de la Torre, Hans Bruijnen, and Nicolas Attigah
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Male ,Baroreceptor ,medicine.medical_treatment ,Blood Pressure ,Pressoreceptors ,Carotid endarterectomy ,030204 cardiovascular system & hematology ,Baroreflex ,Cohort Studies ,03 medical and health sciences ,0302 clinical medicine ,Anesthesia, Conduction ,Humans ,Medicine ,Local anesthesia ,Prospective Studies ,Anesthetics, Local ,Cerebral perfusion pressure ,Prospective cohort study ,Superficial cervical plexus block ,Aged ,Aged, 80 and over ,Endarterectomy, Carotid ,Cervical Plexus Block ,business.industry ,Middle Aged ,Anesthesiology and Pain Medicine ,Blood pressure ,Anesthesia ,cardiovascular system ,Female ,Cardiology and Cardiovascular Medicine ,business ,030217 neurology & neurosurgery ,Anesthesia, Local - Abstract
Objectives Regional anesthesia for patients undergoing carotid endarterectomy is associated with improved intraoperative hemodynamic stability compared with general anesthesia. The authors hypothesized that the reported advantages might be related to attenuated ipsilateral baroreflex control of blood pressure, caused by chemical denervation of the carotid bulb baroreceptor nerve fibers. Design A prospective cohort study. Setting Single-center university hospital. Participants The study included 46 patients undergoing carotid endarterectomy using superficial cervical block. Interventions A noninvasive computational periprocedural measurement of baroreceptor sensitivity was performed in all patients. Two groups were formed, depending on the patients’ subjective response to surgical stimulation regarding the necessity of additional intraoperative local anesthesia (LA) administration on the carotid bulb. Group A (block alone) included 23 patients who required no additional anesthesia, and group B (block + LA) consisted of 23 patients who required additional anesthesia. Measurements and Main Results Baroreceptor sensitivity showed no significant change after application of the block in both groups (group A: median [IQR], 5.19 [3.07-8.54] v 4.96 [3.1-9.07]; p = 0.20) (group B: median [IQR], 4.47 [3.36-8.09] v 4.53 [3.29-8.01]; p = 0.55). There was a significant decrease in baroreceptor sensitivity in group B after intraoperative LA administration (median [IQR], 4.53 [3.29-8.01] v 3.31 [2.26-7.31]; p = 0.04). Conclusions Standard superficial cervical plexus block did not impair local baroreceptor function, and, therefore, it was not related to improved cerebral perfusion in awake patients undergoing carotid endarterectomy. However, direct infiltration of the carotid bulb was associated with the expected attenuation of baroreflex sensitivity.
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- 2016
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38. Übertragung von Tuberkulose während einer kardiopulmonalen Reanimation
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M. A. Weigand, Jürgen Knapp, and Erik Popp
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03 medical and health sciences ,Pneumonia ,0302 clinical medicine ,business.industry ,Emergency Medicine ,Emergency medical services ,Medicine ,030208 emergency & critical care medicine ,030212 general & internal medicine ,Medical emergency ,business ,medicine.disease - Abstract
Hintergrund In der prahospitalen Notfallmedizin hat sich die Anwendung von Einmal-Beatmungsbeuteln weitgehend durchgesetzt. Deshalb wird haufig kein Atemsystemfilter mehr verwendet.
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- 2015
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39. Handlungsempfehlung zur prähospitalen Notfallnarkose beim Erwachsenen
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A. Schaumberg, Jochen Hinkelbein, Carsten Lott, Jan-Thorsten Gräsner, Markus Roessler, Björn Hossfeld, C. Kill, Erik Popp, Matthias Fischer, B. W. Bottiger, Michael Bernhard, A. Bohn, B. Bein, and Volker Wenzel
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Emergency Medicine - Abstract
Die Notfallnarkose ist eine zentrale therapeutische Masnahme in der prahospitalen Notfallmedizin. Das Risiko einer Notfallnarkose ist auserhalb der Klinik deutlich hoher als innerklinisch. Die primaren Ziele der Notfallnarkose sind Hypnose, Analgesie, Schaffung einer Moglichkeit zur Oxygenierung und Ventilation durch eine Atemwegssicherung. Sekundare Ziele der Notfallnarkose sind Amnesie, Anxiolyse, Reduktion von Sauerstoffverbrauch und Atemarbeit, Protektion vitaler Organsysteme sowie Vermeidung sekundarer myokardialer und zerebraler Schaden. Eine kritische Uberprufung der Indikationsstellung zur prahospitalen Notfallnarkose hat vor dem Hintergrund von patienten-, einsatz- und anwenderbezogenen Faktoren zu erfolgen. Die Notfallnarkose als Rapid Sequence Induction beinhaltet ein Standardmonitoring, Praoxygenierung, eine standardisierte Vorbereitung der Notfallnarkose (Narkose-/Notfallmedikamente, Atemwegs- und Beatmungsequipment), die Medikamentenapplikation, (wenn notig) die passagere Aufhebung der HWS-Immobilisation und konsequente manuelle Inline-Stabilisation wahrend des Intubationsmanovers sowie die Atemwegssicherung und die Tubuslagekontrolle. Die Praoxygenierung sollte bei jedem spontanatmenden Notfallpatienten fur einen Zeitraum von mindestens 3–4 min mit dichtsitzender Gesichtsmaske und Beatmungsbeutel mit Sauerstoffreservoir und 12–15 l Sauerstoff/min oder Demand-Ventil mit 100 % Sauerstoff erfolgen. Alternativ kann die Praoxygenierung auch mittels nichtinvasiver Beatmung mit 100 % Sauerstoff durchgefuhrt werden. Die standardisierte Narkosevorbereitung umfasst das Aufziehen und die Kennzeichnung der Narkose- und Notfallmedikamente, die Kontrolle des Beatmungsbeutels inklusive Maske, die Vorbereitung eines Endotrachealtubus inklusive Blockerspritze mit einliegendem Fuhrungsstab, Stethoskop und Fixierungsmaterial, die Bereitstellung alternativer Instrumente zur Atemwegssicherung sowie den Check von Absaugvorrichtung, Beatmungsgerat und Standardmonitoring inklusive Kapnographie. Als Standardmonitoring zur prahospitalen Notfallnarkose sollen das Elektrokardiogramm, die automatische/manuelle Blutdruckmessung und die Pulsoxymetrie zur Anwendung kommen. Eine kontinuierliche Kapnographie erfolgt immer und ohne Ausnahme zur Lagekontrolle der Beatmungshilfen, deren Diskonnektion und Dislokation im Beatmungssystem sowie zum indirekten Monitoring der Hamodynamik. Es sind moglichst zwei periphervenose Verweilkanulen vor Narkoseeinleitung zu etablieren.
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- 2015
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40. Handlungsempfehlung zur prähospitalen Notfallnarkose beim Erwachsenen
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Clemens Kill, A. Schaumberg, Volker Wenzel, Andreas Bohn, B. Bein, Matthias Fischer, Bernd W. Böttiger, Jan-Thorsten Gräsner, Jochen Hinkelbein, Erik Popp, Carsten Lott, Markus Roessler, Björn Hossfeld, and Michael Bernhard
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Emergency Medicine ,Critical Care and Intensive Care Medicine - Published
- 2015
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41. Ausgewählte Krankheitsbilder und deren Komplikationsmanagement
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Erik Popp, Uwe Hecker, and Christoph Schramm
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- 2018
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42. Design and validation of a clinical scale for prehospital stroke recognition, severity grading and prediction of large vessel occlusion: the shortened NIH Stroke Scale for emergency medical services
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Jan Christoph, Purrucker, Florian, Härtig, Hardy, Richter, Andreas, Engelbrecht, Johannes, Hartmann, Jonas, Auer, Christian, Hametner, Erik, Popp, Peter Arthur, Ringleb, Simon, Nagel, and Sven, Poli
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Male ,Emergency Medical Services ,stroke severity grading ,Research ,Arterial Occlusive Diseases ,Sensitivity and Specificity ,Severity of Illness Index ,Brain Ischemia ,Stroke ,ROC Curve ,Neurology ,Predictive Value of Tests ,emergency medicine ,Area Under Curve ,large vessel occlusion ,Humans ,Female ,cardiovascular diseases ,Triage ,Retrospective Studies - Abstract
Objective To develop an NIH Stroke Scale (NIHSS)-compatible, all-in-one scale for rapid and comprehensive prehospital stroke assessment including stroke recognition, severity grading and progression monitoring as well as prediction of large vessel occlusion (LVO). Methods Emergency medical services (EMS) personnel and stroke physicians (n=326) rated each item of the NIHSS regarding suitability for prehospital use; best rated items were included. Stroke recognition was evaluated retrospectively in 689 consecutive patients with acute stroke or stroke mimics, prediction of LVO in 741 consecutive patients with ischaemic stroke with acute vessel imaging independent of admission NIHSS score. Results Nine of the NIHSS items were rated as ‘suitable for prehospital use.’ After excluding two items in order to increase specificity, the final scale (termed shortened NIHSS for EMS, sNIHSS-EMS) consists of ‘level of consciousness’, ‘facial palsy’, ‘motor arm/leg’, ‘sensory’, ‘language’ and ‘dysarthria’. Sensitivity for stroke recognition of the sNIHSS-EMS is 91% (95% CI 86 to 94), specificity 52% (95% CI 47 to 56). Receiver operating curve analysis revealed an optimal cut-off point for LVO prediction of ≥6 (sensitivity 70% (95% CI 65 to 76), specificity 81% (95% CI 76 to 84), positive predictive value 70 (95% CI 65 to 75), area under the curve 0.81 (95% CI 0.78 to 0.84)). Test characteristics were non-inferior to non-comprehensive scales. Conclusions The sNIHSS-EMS may overcome the sequential use of multiple emergency stroke scales by permitting parallel stroke recognition, severity grading and LVO prediction. Full NIHSS-item compatibility allows for evaluation of stroke progression starting at the prehospital phase.
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- 2017
43. Cadaveric study of movement in the unstable upper cervical spine during emergency management: tracheal intubation and cervical spine immobilisation—a study protocol for a prospective randomised crossover trial
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Michael Kreinest, Shiyao Liao, Erik Popp, Frank Weilbacher, Niko R. E. Schneider, Matthias Münzberg, and Petra Hüttlin
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Laryngeal tube ,musculoskeletal diseases ,medicine.medical_specialty ,Emergency Medical Services ,medicine.medical_treatment ,Movement ,Laryngoscopy ,iaryngoscopy ,intubation ,03 medical and health sciences ,Immobilization ,0302 clinical medicine ,Clinical Protocols ,030202 anesthesiology ,medicine ,Protocol ,Cadaver ,Intubation, Intratracheal ,Intubation ,fiberoptic ,Humans ,Prospective Studies ,dural sac ,Cross-Over Studies ,medicine.diagnostic_test ,business.industry ,cervical collar ,Tracheal intubation ,myelography ,030208 emergency & critical care medicine ,General Medicine ,Surgery ,laryngeal ,Emergency Medicine ,Cervical Vertebrae ,Cervical collar ,Airway management ,unstable upper cervical spine ,Cadaveric spasm ,business ,Myelography - Abstract
IntroductionEmergency management of upper cervical spine injuries often requires cervical spine immobilisation and some critical patients also require airway management. The movement of cervical spine created by tracheal intubation and cervical spine immobilisation can potentially exacerbate cervical spinal cord injury. However, the evidence that previous studies have provided remains unclear, due to lack of a direct measurement technique for dural sac's space during dynamic processes. Our study will use myelography method and a wireless human motion tracker to characterise and compare the change of dural sac's space during tracheal intubations and cervical spine immobilisation in the presence of unstable upper cervical spine injury such as atlanto-occipital dislocation or type II odontoid fracture.Methods and analysisPerform laryngoscopy and intubation, video laryngoscope intubation, laryngeal tube insertion, fiberoptic intubation and cervical collar application on cadaveric models of unstable upper cervical spine injury such as atlanto-occipital dislocation or type II odontoid fracture. The change of dural sac's space and the motion of unstable cervical segment are recorded by video fluoroscopy with previously performing myelography, which enables us to directly measure dural sac's space. Simultaneously, the whole cervical spine motion is recorded at a wireless human motion tracker. The maximum dural sac compression and the maximum angulation and distraction of the injured segment are measured by reviewing fluoroscopic and myelography images.Ethics and disseminationThis study protocol has been approved by the Ethics Committee of the State Medical Association Rhineland-Palatinate, Mainz, Germany. The results will be published in relevant emergency journals and presented at relevant conferences.Trial registration numberDRKS00010499.
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- 2017
44. Spinal movement and dural sac compression during airway management in a cadaveric model with atlanto-occipital instability
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Niko R. E. Schneider, Anne Stehr, Shiyao Liao, Stefan Matschke, Erik Popp, Frank Weilbacher, Paul Alfred Grützner, and Michael Kreinest
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Laryngeal tube ,Male ,medicine.medical_treatment ,Dura mater ,Laryngoscopy ,Joint Dislocations ,03 medical and health sciences ,0302 clinical medicine ,Spinal cord compression ,medicine ,Cadaver ,Pressure ,Humans ,Orthopedics and Sports Medicine ,Joint dislocation ,Airway Management ,Range of Motion, Articular ,Myelography ,Aged ,Aged, 80 and over ,medicine.diagnostic_test ,business.industry ,030208 emergency & critical care medicine ,Anatomy ,medicine.disease ,body regions ,medicine.anatomical_structure ,Atlanto-Occipital Joint ,Fluoroscopy ,Cervical Vertebrae ,Surgery ,Airway management ,Female ,Dura Mater ,business ,Spinal Cord Compression ,030217 neurology & neurosurgery ,Cervical vertebrae - Abstract
To analyze the compression of the dural sac and the cervical spinal movement during performing different airway interventions in case of atlanto-occipital dislocation. In six fresh cadavers, atlanto-occipital dislocation was performed by distracting the opened atlanto-occipital joint capsule and sectioning the tectorial membrane. Airway management was done using three airway devices (direct laryngoscopy, video laryngoscopy, and insertion of a laryngeal tube). The change of dural sac’s width and intervertebral angulation in stable and unstable atlanto-occipital conditions were recorded by video fluoroscopy with myelography. Three-dimensional overall movement of cervical spine was measured in a wireless human motion track system. Compared with a mean dural sac compression of − 0.5 mm (− 0.7 to − 0.3 mm) in stable condition, direct laryngoscopy caused an increased dural sac compression of − 1.6 mm (− 1.9 to − 0.6 mm, p = 0.028) in the unstable atlanto-occipital condition. No increased compression on dural sac was found using video laryngoscopy or the laryngeal tube. Moreover, direct laryngoscopy caused greater overall extension and rotation of cervical spine than laryngeal tube insertion in both stable and unstable conditions. Among three procedures, the insertion of a laryngeal tube took the shortest time. In case of atlanto-occipital dislocation, intubation using direct laryngoscopy exacerbates dural sac compression and may cause damage to the spinal cord.
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- 2017
45. Invasive Techniken in der Notfallmedizin
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Erik Popp and B. Gliwitzky
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medicine.medical_specialty ,business.industry ,Emergency medicine ,Emergency Medicine ,medicine ,business - Published
- 2019
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46. [Clamshell thoracotomy after thoracic knife wounds]
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Marcus, Rudolph, Niko R E, Schneider, and Erik, Popp
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Treatment Outcome ,Critical Care ,Thoracic Injuries ,Thoracotomy ,Multiple Trauma ,Resuscitation ,Humans ,Wounds, Penetrating ,Algorithms - Abstract
Resuscitation in the event of traumatic cardiac arrest was for a long time considered to be a less than promising technique to employ; however, current data indicate that the prospects of success need not be any poorer than for resuscitation due to cardiac distress. The targeted and rapid remedying of reversible causes can re-establish the circulatory function and the European Resuscitation Council (ERC) algorithm for traumatic cardiac arrest is a helpful guide in this respect. This case report illustrates the resolute implementation of this algorithm in the prehospital environment in the case of an attempted suicide by a thoracic knife wound.
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- 2017
47. Recommended practice for out-of-hospital emergency anaesthesia in adults: Statement from the Out-of-Hospital Emergency Anaesthesia Working Group of the Emergency Medicine Research Group of the German Society of Anaesthesiology and Intensive Care
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Jan-Thorsten Graesner, Andreas Bohn, Bjoern Hossfeld, Markus Roessler, B. Bein, Carsten Lott, Alin Schaumberg, Bernd W. Boettiger, Erik Popp, Matthias Fischer, Clemens Kill, Jochen Hinkelbein, Volker Wenzel, and Michael Bernhard
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Suction (medicine) ,medicine.medical_specialty ,Emergency Medical Services ,Critical Care ,medicine.medical_treatment ,law.invention ,03 medical and health sciences ,0302 clinical medicine ,030202 anesthesiology ,law ,Anesthesiology ,Risk Factors ,Intensive care ,Germany ,medicine ,Intubation ,Humans ,Anesthesia ,Societies, Medical ,Capnography ,medicine.diagnostic_test ,business.industry ,030208 emergency & critical care medicine ,Rapid sequence induction ,3. Good health ,Pulse oximetry ,Anesthesiology and Pain Medicine ,Emergency medicine ,Ventilation (architecture) ,Practice Guidelines as Topic ,Emergency Medicine ,Airway management ,business - Abstract
Emergency anaesthesia is an important therapeutic measure in out-of-hospital emergency medicine. The associated risks are considerably higher than those of in-hospital anaesthesia. The primary objectives of emergency anaesthesia are hypnosis, analgesia, oxygenation and ventilation through airway management. The secondary objectives of emergency anaesthesia are amnesia, anxiolysis, the reduction of oxygen consumption and respiratory work, the protection of vital organs and the avoidance of secondary myocardial and cerebral damage. A critical evaluation of the indications for outof- hospital emergency anaesthesia must take into consideration patient, case and provider-related factors. Rapid sequence induction of emergency anaesthesia includes standard monitoring, preoxygenation, standardised preparation of emergency anaesthesia, drug administration, manual in-line stabilisation during intubation (if necessary), airway management and checking of correct tube placement. Spontaneously breathing casualties should receive preoxygenation for at least 3 to 4 min with a tight-fitting facemask with reservoir using 12 to 15 l min_1 of oxygen or with a demand valve providing 100% oxygen. As an alternative, preoxygenation may be performed as noninvasive ventilation with 100% oxygen. Standardised anaesthesia preparation comprises filling drugs into syringes and labelling them, checking ventilation equipment, preparing endotracheal tube and syringe for inflating the cuff and the introducer, stethoscope and fixation material, preparing alternative instruments for airway management as well as checking suction, ventilation and standard monitoring devices, including capnography. Standard monitoring for out-of-hospital emergency anaesthesia comprises ECG, blood pressure measurement and pulse oximetry. Continuous capnography is always and exclusively performed to check the placement of airway devices, as well as to indirectly monitor haemodynamics.
- Published
- 2016
48. Wenn Beatmung, dann mit Filter. Immer
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Erik Popp, M. A. Weigand, and Jürgen Knapp
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business.industry ,Emergency Medicine ,Medicine ,Medical emergency ,business ,medicine.disease - Published
- 2016
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49. Unified Nanotechnology Format: One Way to Store Them All
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David Kuťák, Erik Poppleton, Haichao Miao, Petr Šulc, and Ivan Barišić
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DNA nanotechnology ,file format ,molecular file formats ,computer-aided design ,coarse-grained simulations ,DNA origami ,Organic chemistry ,QD241-441 - Abstract
The domains of DNA and RNA nanotechnology are steadily gaining in popularity while proving their value with various successful results, including biosensing robots and drug delivery cages. Nowadays, the nanotechnology design pipeline usually relies on computer-based design (CAD) approaches to design and simulate the desired structure before the wet lab assembly. To aid with these tasks, various software tools exist and are often used in conjunction. However, their interoperability is hindered by a lack of a common file format that is fully descriptive of the many design paradigms. Therefore, in this paper, we propose a Unified Nanotechnology Format (UNF) designed specifically for the biomimetic nanotechnology field. UNF allows storage of both design and simulation data in a single file, including free-form and lattice-based DNA structures. By defining a logical and versatile format, we hope it will become a widely accepted and used file format for the nucleic acid nanotechnology community, facilitating the future work of researchers and software developers. Together with the format description and publicly available documentation, we provide a set of converters from existing file formats to simplify the transition. Finally, we present several use cases visualizing example structures stored in UNF, showcasing the various types of data UNF can handle.
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- 2021
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