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This is an open access title available under the terms of a CC BY-NC-ND 4.0 International licence. It is free to read at Oxford Academic and offered as a free PDF download from OUP and selected open access locations. Jasper's Basic Mechanisms of the Epilepsies has served as the definitive reference in the field of basic research in the epilepsies for five decades through four well-regarded editions. Since its inception, the book has been an indispensable must-read and belongs in the hands of every experimental epilepsy investigator, practicing epileptologist, clinical neuroscientist, and student for both clinical and basic science reference, doctoral and board exam preparation. This fifth edition is the most ambitious yet and remains the definitive reference in the field, providing encyclopedic and updated coverage of the current understanding of basic research in the epilepsies, while also mapping new research directions for the next decade, and reviewing how molecular laboratory evidence is now being translated into new therapeutics. In 79 chapters, the book considers the role of interactions between neurons, synapses, and glia in the initiation, spread, and arrest of seizures. It examines mechanisms of excitability, synchronization, seizure susceptibility and, ultimately, their contributions to epileptogenesis. It provides a framework for expanding the monogenic epilepsy genome and understanding the complex heredity responsible for common epilepsies. It explores the molecular and cellular disease mechanisms of ion channelopathies, developmental epilepsy genes, and progressive myoclonic epilepsies. It considers newly emerging mechanisms of epilepsy comorbidities. And, for the first time, it describes current efforts to identify biomarkers of disease progression and translate discoveries of epilepsy disease mechanisms into new therapeutic strategies at the frontier of molecular medicine.

This book brings together the exciting new findings that will bring us closer to a better understanding of the alterations of neuronal connectivity in autistic brains. This volume authoritatively covers the epidemiology, physiology, neurodevelopment, genetics, environmental influences, imaging studies, neuroanatomy, and neurochemistry of autism spectrum disorders. While the neurobiology of autism is still a long way from being understood, this book posits techniques, such as using brain imaging to find signatures in early days of life, that could help move the diagnosis and help identify neural pathways. Understanding these mechanisms opens the possibility to pharmacological, behavioral, and psychosocial therapeutic interventions. With contributions from the leading international autism researchers, Neurobiology of Autism Spectrum Disorders is the go-to reference for researchers and clinicians with an interest in understanding the underlying neurobiologyof autism spectrum disorders.

Ländliche Regionen werden mit ihrer lokalen Architektur zu wenig beachtet. Das möchte dieses Buch ändern. Eine Fülle von realisierten Projekten zeigt, welche Qualitäten hier zu entdecken sind. Architektur kann viel zu einem guten Leben auf dem Land beitragen. Das veranschaulichen Wohnhäuser, landwirtschaftliche Bauten, Dorfläden, Werkstätten, Bürobauten, Weingüter, Hotels, Museen, Kapellen, Sportstätten und öffentliche Bauten. Der geografische Schwerpunkt liegt in Deutschland, Österreich und der Schweiz, darüber hinaus werden beispielhafte Projekte aus dem europäischen Ausland vorgestellt. Ergänzend werden Regionen und Orte gezeigt, die in besonderer Weise ihre Gesamtentwicklung begleitet haben – von Schrumpfung bis Wachstum. Essays zum Realisierungsprozess von Bauprojekten, zu wichtigen Bautypologien, zur Infrastruktur und dazu, was sich vom Bauen auf dem Land lernen lässt, runden diesen attraktiven Band ab. Der Katalog porträtiert 70 Projekte zahlreicher namhafter Büros, u. a. Architekten Innauer Matt, Bernardo Bader Architekten, Florian Nagler Architekten, Gion A. Caminada, Max und Jakob Giese Architektur und Max Dudler.

Atmospheric Nitrogen Deposition in Global Forests: Spatial Variation, Impacts, and Management Implications provides the most comprehensive knowledge on spatial variation and ecological impacts of reactive nitrogen deposition in global forests, as well as forest management options to mitigate the negative impacts. Written and edited by international experts in the field, this book synthesizes recent research developments and insights in monitoring and modeling nitrogen deposition in global forests. The book also assesses ecological impacts of enhanced nitrogen deposition on forest structure and function and responses of forest ecosystems to decreasing nitrogen deposition in regions such as the European Union and North America. Finally, the book reviews indicators and thresholds for nitrogen saturation in global forests and analyzes remediation options to reduce impacts of excess nitrogen deposition. This is an important resource for researchers in forestry and biodiversity conservation, as well as graduate students, policymakers and others who want to understand environmental issues of reactive nitrogen deposition in global forests. - Offers a systematic view of the ecological impacts of enhanced nitrogen deposition - Provides the most comprehensive knowledge on spatial variation and the ecological impacts of reactive nitrogen deposition in global forests - Presents expert research and findings on forest management options to remediate negative impacts

Dieses Buch liefert eine fundierte Bestandsaufnahme zur Geschichte des Umgangs mit Non-Financial Risks und leitet daraus nützliche Empfehlungen für das künftige Risikomanagement ab. Im Jahr 1995 hat der Untergang von Barings Bank durch „rogue trading“ (Nick Leeson) für nachhaltige Aufmerksamkeit gesorgt, 1997 sind erste Studien zu Operational Risk in Banken erschienen (BBA/C&L), 1999 das erste Konsultationspapier zu „Basel II“, in dem „other risks“ (aus denen später „operational risk“ wurde) thematisiert wurden. Somit ist ca. ein Vierteljahrhundert verstrichen, seit erste Banken begannen, sich systematisch mit dieser Disziplin (die seit ca. 10 Jahren im breiteren Sinne, unter Einschluss von Reputationsrisiken und Strategischen Risiken zunehmend unter „Non-Financial Risk“ firmiert) zu beschäftigen. Versicherungen und andere Finanzdienstleister haben zu einem etwas späteren Zeitpunkt begonnen, sich mit diesen Themen intensiv auseinanderzusetzen. Ein Rückblick auf diese Zeitspanne und ein Ausblick auf die Zukunft scheint daher lehrreich zu sein. Der Autor ist selbst seit Januar 1999 in dem Thema unterwegs (HypoVereinsbank, später Commerzbank, KPMG, Deutsche Bank, KPMG) – ergänzend zahlreiche Vorlesungen, Seminare, Konferenzen und Vorträge zu Operational Risk und Non-Financial Risk Management.

Bauernhäuser prägen die Identität der Allgäuer Kulturlandschaft seit Jahrhunderten.Die Zukunft bäuerlicher Hofstellen ist jedoch durch den Strukturwandel der Landwirtschaft bedroht,mit den Bauten droht die Kulturlandschaft zu verschwinden.Die Publikation Weiter|Nutzen zeigt rund zwanzig besonders interessante Projekte, in denen dieAltbausubstanz landwirtschaftlicher Gebäude auf vorbildliche Weise zu neuem Leben erweckt wurde. Damitsollen Eigentümer|innen und potentielle Bauherr|inn|en angeregt werden, mit dem sensiblen Erhalt ihrerHöfe einen Beitrag zum authentischen Gesamterscheinungsbild der Region zu leisten. Gegliedert werden diehochwertig fotografierten und gestalteten Präsentationen der Projekte nach spezifischen Landschaftsbilderndes Allgäus.Speziell für die Buchpublikation von Studierenden der Hochschule Augsburg erstellte Planunterlagen erlaubeneinen guten Vergleich vor und nach der Umbauphase der jeweiligen Hofstellen.Begleitend erörtern eine Historikerin, Architekt|innen, Landschaftsplaner, Museumsleiter und ein ehemaligerKreisbaumeister Entwicklung und Perspektive der Baukultur, Typologie und Sanierungsmöglichkeiten. Dasunterstreicht die Betrachtung der jeweiligen Fälle, die in einer Synopse mit Projektdaten verglichenwerden. Ein Fachteil gibt abschließend konkrete praktische Ratschläge zum Umbau.Zudem ist eine Bildstrecke mit historischen Fotografien eingewoben, die einen Einblick in vergangene Zeitender Allgäuer Kulturlandschaft gewährt.

Forest Microbiology, Volume Two: Forest Tree Health highlights a range of emerging microbial phytopathogens of forest trees, along with novel approaches for managing tree pests and diseases in a changing climate. The book provides an overview of selected microbial pathogens of forest trees, with an emphasis on their biology, lifecycle, spreading mechanisms, impact on affected tree species and current and prospective control strategies. At the same time, the impact of tree microbiomes on host fitness is discussed. Beneficial components of tree microbiota are presented, along with their functional role in tree nutrition, immunity and disease resistance. In addition, this volume addresses the many functions of microbial disease agents of trees including fungi, bacteria, viruses and phytoplasma. Strong emphasis is placed on the genetics, biochemistry, physiology, evolutionary biology and population dynamics of the microorganisms involved. This title is a key resource for foresters and forest pathology practitioners, as well as plant biologists. - Provides an overview of selected microbial pathogens of forest trees, with an emphasis on their biology, lifecycle, spreading mechanisms, impact on affected tree species and current and prospective control strategies - Highlights novel approaches to managing tree pests and diseases in a changing climate - Addresses the many functions of microbial disease agents of trees, including fungi, fungi, bacteria, viruses and phytoplasma

Neuroendocrine neoplasms comprise a large family of proliferative lesions that involve almost every part of the body. Our understanding of their cells of origin as well as the pathology, pathophysiology and genetics of these neoplasms has made tremendous advances in the last few decades. While they are often discussed as separate entities in textbooks of gastroenteropancreatic pathology and pulmonary pathology, their scope is much broader. The book conveys the similarities and differences of these fascinating tumors that may be found from the hypothalamus and pituitary to the rectum, and in soft tissue as well as in many organs. Written by experts in the field, the authors emphasize their structural, functional, predictive and prognostic features and attempt to provide the clinical context that allows improved diagnosis and therapy while building on the genetics that clarifies patterns of inheritance and predisposition to tumor development through precursor lesions.The Spectrum of Neuroendocrine Neoplasia provides a broad overview of neuroendocrine neoplasms using a practical approach to diagnosis, histological classification and therapy, and presents the most important and significant developments of the technologies used to diagnose, classify and treat them.

Mirroring the long-established structure of the financial industry, EU financial regulation as we know it today approaches banking, insurance and investment services separately and often divergently. In recent decades however, the clear separation between financial sectors has gradually evaporated, as business lines have converged across sectors and FinTech solutions have emerged which do not fit traditional sector boundaries.As the contours of the traditional tripartition in the financial industry have faded, the diverging regulatory and supervisory treatment of these sectors has become increasingly at odds with economic reality. This book brings together insights developed by distinguished researchers and industry professionals in a series of articles analysing the main areas of EU financial regulation from a cross-sectoral perspective. For each specific research theme – including prudential regulation, corporate governance and conduct of business rules – the similarities, as well as gaps, overlaps and unjustifiable differences between banking, securities and insurance regulation, are clearly presented and discussed. This innovative research approach is aimed at informing lawmakers and policymakers on potential improvements to EU financial regulation whilst also supporting legal and compliance professionals applying the current framework or looking to streamline compliance processes.

Publikacja jest poświęcona problematyce nadzoru korporacyjnego z perspektywy jego oddziaływania na stabilność podmiotów w sektorze bankowym. Autorka zwraca uwagę na specyficzną rolę banków we współczesnej gospodarce i na związane z nią implikacje w obszarze mechanizmów corporate governance. Ważną częścią książki są wyniki badań empirycznych przeprowadzonych w polskich bankach publicznych. Na ich podstawie dokonano oceny wpływu wybranych standardów i charakterystyk nadzoru korporacyjnego na stabilność banków mierzoną współczynnikiem adekwatności kapitałowej.

This book presents an essential overview of beta-lactams and their medicinal value and use in the preparation of other biologically active compounds. Written by internationally respected authors, the individual chapters explore beta-lactams'synthesis, their mechanism of formation, biological effects, and function as base materials for other heterocycles of major importance.

This book critically evaluates the causal link between cell division machinery and disease. Further, it identifies key open questions in the field and the means for exploring them. Throughout the various chapters, internationally known contributors present the evidence for and against a causal link between key elements of the cell division machinery and diseases such as cancer, neuropathologies, aging, and infertility. A more clinically oriented chapter further discusses the current and future applications of anti-mitotic drugs in these diseases. Cell Division Machinery and Disease is essential reading for graduate or advanced graduate students, researchers or scientists working on cell division as well as clinicians interested in the molecular mechanisms of the discussed diseases.

Medical Epigenetics provides a comprehensive analysis of the importance of epigenetics to health management. The purpose of this book is to fill a current need for a comprehensive volume on the medical aspects of epigenetics with a focus on human systems, epigenetic diseases that affect these systems and modes of treating epigenetic-based disorders and diseases. The intent of this book is to provide a stand-alone comprehensive volume that will cover all human systems relevant to epigenetic maladies and all major aspects of medical epigenetics. The overall goal is to provide the leading book on medical epigenetics that will be useful not only to physicians, nurses, medical students and many others directly involved with health care, but also investigators in life sciences, biotech companies, graduate students and many others who are interested in more applied aspects of epigenetics. Research in the area of translational epigenetics is a cornerstone of this volume. Critical reviews dedicated to the burgeoning role of epigenetics in medical practice Coverage of emerging topics including twin epigenetics as well as epigenetics of gastrointestinal disease, muscle disorders, endocrine disorders, ocular medicine, pediatric diseases, sports medicine, noncoding RNA therapeutics, pain management and regenerative medicine Encompasses a disease-oriented perspective of medical epigenetics as well as diagnostic and prognostic epigenetic approaches to applied medicine