24 results on '"Halderman AA"'
Search Results
2. Nasal endoscopy score thresholds to trigger consideration of chronic rhinosinusitis treatment escalation and implications for disease control.
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Sedaghat AR, Cotter RA, Alobid I, Alsaleh S, Anselmo-Lima WT, Bernal-Sprekelsen M, Chandra RK, Constantinidis J, Fokkens WJ, Franzese C, Gray ST, Halderman AA, Holbrook EH, Hopkins C, Hwang PH, Kuan EC, Landis BN, Lund VJ, McCoul ED, Niederberger-Leppin V, O'Brien EK, Philpott CM, Pletcher SD, Pynnonen MA, Reitsma S, Rimmer J, Toppila-Salmi S, Wang EW, Wang MB, Wise SK, Woodworth BA, Yao WC, and Phillips KM
- Abstract
Background: In the absence of direct evidence supporting how to use nasal endoscopy findings to judge chronic rhinosinusitis (CRS) disease control, experts' practice patterns could provide guidance., Methodology: Participants consisted of a diverse group of twenty-nine rhinologists. Participants were presented with every possible combination of bilateral nasal endoscopy findings represented by the modified Lund-Kennedy (MLK; range: 0-12) endoscopic scoring system and Nasal Polyp Score (NPS; range: 0-8). Reflecting the practical consequence of CRS disease control assessment, participants were asked whether they would consider CRS treatment escalation based on each scenario in the absence of any CRS symptoms, and how strongly they considered escalating therapy. The same scenarios were then presented in the context of 1 burdensome CRS symptom and participants again were asked whether they would consider treatment escalation., Results: The median threshold total MLK score for considering treatment escalation was ≥4 and 75.9% of participants' MLK thresholds were within 1 point of 4. The median threshold total NPS for considering treatment escalation was ≥3 and 62.5% of participants' NPS thresholds were within 1 point of 3. Endoscopy score thresholds decreased in the presence of 1 burdensome symptom and generally increased when requiring stronger affirmation for considering CRS treatment escalation., Conclusion: Reflecting the practice patterns of a diverse group of rhinologists, MLK score ≥4 or NPS ≥3 may serve as thresholds for considering CRS treatment escalation. Alternatively, MLK score.
- Published
- 2024
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3. International Consensus Statement on Allergy and Rhinology: Sinonasal Tumors.
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Kuan EC, Wang EW, Adappa ND, Beswick DM, London NR Jr, Su SY, Wang MB, Abuzeid WM, Alexiev B, Alt JA, Antognoni P, Alonso-Basanta M, Batra PS, Bhayani M, Bell D, Bernal-Sprekelsen M, Betz CS, Blay JY, Bleier BS, Bonilla-Velez J, Callejas C, Carrau RL, Casiano RR, Castelnuovo P, Chandra RK, Chatzinakis V, Chen SB, Chiu AG, Choby G, Chowdhury NI, Citardi MJ, Cohen MA, Dagan R, Dalfino G, Dallan I, Dassi CS, de Almeida J, Dei Tos AP, DelGaudio JM, Ebert CS, El-Sayed IH, Eloy JA, Evans JJ, Fang CH, Farrell NF, Ferrari M, Fischbein N, Folbe A, Fokkens WJ, Fox MG, Lund VJ, Gallia GL, Gardner PA, Geltzeiler M, Georgalas C, Getz AE, Govindaraj S, Gray ST, Grayson JW, Gross BA, Grube JG, Guo R, Ha PK, Halderman AA, Hanna EY, Harvey RJ, Hernandez SC, Holtzman AL, Hopkins C, Huang Z, Huang Z, Humphreys IM, Hwang PH, Iloreta AM, Ishii M, Ivan ME, Jafari A, Kennedy DW, Khan M, Kimple AJ, Kingdom TT, Knisely A, Kuo YJ, Lal D, Lamarre ED, Lan MY, Le H, Lechner M, Lee NY, Lee JK, Lee VH, Levine CG, Lin JC, Lin DT, Lobo BC, Locke T, Luong AU, Magliocca KR, Markovic SN, Matnjani G, McKean EL, Meço C, Mendenhall WM, Michel L, Na'ara S, Nicolai P, Nuss DW, Nyquist GG, Oakley GM, Omura K, Orlandi RR, Otori N, Papagiannopoulos P, Patel ZM, Pfister DG, Phan J, Psaltis AJ, Rabinowitz MR, Ramanathan M Jr, Rimmer R, Rosen MR, Sanusi O, Sargi ZB, Schafhausen P, Schlosser RJ, Sedaghat AR, Senior BA, Shrivastava R, Sindwani R, Smith TL, Smith KA, Snyderman CH, Solares CA, Sreenath SB, Stamm A, Stölzel K, Sumer B, Surda P, Tajudeen BA, Thompson LDR, Thorp BD, Tong CCL, Tsang RK, Turner JH, Turri-Zanoni M, Udager AM, van Zele T, VanKoevering K, Welch KC, Wise SK, Witterick IJ, Won TB, Wong SN, Woodworth BA, Wormald PJ, Yao WC, Yeh CF, Zhou B, and Palmer JN
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- Humans, Quality of Life, Hypersensitivity, Head and Neck Neoplasms, Paranasal Sinus Neoplasms therapy, Paranasal Sinus Neoplasms pathology
- Abstract
Background: Sinonasal neoplasms, whether benign and malignant, pose a significant challenge to clinicians and represent a model area for multidisciplinary collaboration in order to optimize patient care. The International Consensus Statement on Allergy and Rhinology: Sinonasal Tumors (ICSNT) aims to summarize the best available evidence and presents 48 thematic and histopathology-based topics spanning the field., Methods: In accordance with prior International Consensus Statement on Allergy and Rhinology documents, ICSNT assigned each topic as an Evidence-Based Review with Recommendations, Evidence-Based Review, and Literature Review based on the level of evidence. An international group of multidisciplinary author teams were assembled for the topic reviews using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses format, and completed sections underwent a thorough and iterative consensus-building process. The final document underwent rigorous synthesis and review prior to publication., Results: The ICSNT document consists of four major sections: general principles, benign neoplasms and lesions, malignant neoplasms, and quality of life and surveillance. It covers 48 conceptual and/or histopathology-based topics relevant to sinonasal neoplasms and masses. Topics with a high level of evidence provided specific recommendations, while other areas summarized the current state of evidence. A final section highlights research opportunities and future directions, contributing to advancing knowledge and community intervention., Conclusion: As an embodiment of the multidisciplinary and collaborative model of care in sinonasal neoplasms and masses, ICSNT was designed as a comprehensive, international, and multidisciplinary collaborative endeavor. Its primary objective is to summarize the existing evidence in the field of sinonasal neoplasms and masses., (© 2023 The Authors. International Forum of Allergy & Rhinology published by Wiley Periodicals LLC on behalf of American Academy of Otolaryngic Allergy and American Rhinologic Society.)
- Published
- 2024
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4. Determinants of physician assessment of chronic rhinosinusitis disease control using EPOS 2020 criteria and the importance of incorporating patient perspectives of disease control.
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Sedaghat AR, Caradonna DS, Chandra RK, Franzese C, Gray ST, Halderman AA, Hopkins C, Kuan EC, Lee JT, McCoul ED, O'Brien EK, Pletcher SD, Pynnonen MA, Wang EW, Wise SK, Woodworth BA, Yao WC, and Phillips KM
- Abstract
Background: We identify chronic rhinosinusitis (CRS) manifestations associated with how rhinologists assess CRS control, with a focus on patient perspectives (patient-reported CRS control)., Methods: Fifteen rhinologists were provided with real-world data from 200 CRS patients. Participating rhinologists first classified patients' CRS control as "controlled," "partly controlled," and "uncontrolled" using seven CRS manifestations reflecting European Position Paper on Rhinosinusitis and Nasal Polyps (EPOS) CRS control criteria (nasal obstruction, drainage, impaired smell, facial pain/pressure, sleep disturbance, use of systemic antibiotics/corticosteroids in past 6 months, and nasal endoscopy findings) and patient-reported CRS control. They then classified patients' CRS control without knowledge of patient-reported CRS control. Interrater reliability and agreement of rhinologist-assessed CRS control with patient-reported CRS control and EPOS guidelines were determined., Results: CRS control classification with and without knowledge of patient-reported CRS control was highly consistent across rhinologists (κ
w = 0.758). Rhinologist-assessed CRS control agreed with patient-reported CRS control significantly better when rhinologists had knowledge of patient-reported CRS control (κw = 0.736 vs. κw = 0.554, p < 0.001). Patient-reported CRS control, nasal obstruction, drainage, and endoscopy findings were most strongly associated with rhinologists' assessment of CRS control. Rhinologists' CRS control assessments weakly agreed with EPOS CRS control guidelines with (κw = 0.529) and without (κw = 0.538) patient-reported CRS control. Rhinologists classified CRS as more controlled than EPOS guidelines in almost 50% of cases., Conclusions: This study directly demonstrates the importance of patient-reported CRS control as a dominant influence on rhinologists' CRS control assessment. Knowledge of patient-reported CRS control may better align rhinologists' CRS control assessments and treatment decisions with patients' perspectives., (© 2023 The Authors. International Forum of Allergy & Rhinology published by Wiley Periodicals LLC on behalf of American Academy of Otolaryngic Allergy and American Rhinologic Society.)- Published
- 2023
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5. Tips and tricks for management of the dysfunctional maxillary sinus.
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Chung SY and Halderman AA
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- Humans, Endoscopy, Chronic Disease, Anti-Bacterial Agents, Maxillary Sinus surgery, Maxillary Sinusitis etiology, Maxillary Sinusitis surgery
- Abstract
Purpose of Review: To review the various factors associated with the most common cause of maxillary sinus dysfunction; recalcitrant chronic maxillary sinusitis (RCMS). In addition, available medical and surgical management options are discussed along with various tips and tricks for optimal management., Recent Findings: Defects in mucociliary clearance, immunodeficiency, anatomic factors, and infectious etiologies have been implicated in dysfunction of the maxillary sinus leading to RCMS. Medical management including oral antibiotics or topical drugs have shown varying degrees of success. Endoscopic modified medial maxillectomy (EMMM) has been shown to significantly improve symptoms in patients with RCMS., Summary: A dysfunctional maxillary sinus presents a clinical challenge. A thorough evaluation of any potential contributing factors must be done in addition to an assessment of the adequacy of prior surgical treatment of the maxillary sinus. Beyond the middle meatal antrostomy, EMMM can be used to effectively address RCMS. In cases that fail EMMM, removal of the condemned mucosa to encourage auto-obliteration of the sinus can be considered., (Copyright © 2022 Wolters Kluwer Health, Inc. All rights reserved.)
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- 2023
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6. Endoscopic endonasal approach to the craniovertebral junction.
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Halderman AA and Barnett SL
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The surgical approach to lesions of the ventral craniovertebral junction (CVJ) has evolved significantly in the last several years with the advent of endoscopic skull base surgery. Differing pathologies of the CVJ can result in irreducible compression of the cervicomedullary region. The endoscopic endonasal approach lends itself well to this region due to the ventral location, and while there is a steep learning curve, is a safe and effective way to perform decompression of the cervicomedullary region. Herein, we discuss the anatomy of the CVJ, preoperative evaluation and surgical considerations, our surgical approach, complications, and outcomes., Competing Interests: The authors declare no conflicts of interest., (© 2022 The Authors. World Journal of Otorhinolaryngology ‐ Head and Neck Surgery published by John Wiley & Sons, Ltd on behalf of Chinese Medical Association.)
- Published
- 2022
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7. Gender and authorship trends in rhinology, allergy, and skull-base literature from 2008 to 2018.
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Halderman AA, Rao A, Desai-Markowski S, Yang A, Luong AU, O'Brien E, Gray ST, Lal D, Lin SY, Orlandi R, and Wise SK
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- Bibliometrics, Female, Humans, Male, Sex Factors, Skull Base, Authorship, Hypersensitivity
- Abstract
Background: A recent analysis suggested potential narrowing of the gender gap in research productivity in the field of rhinology. This analysis did not, however, provide insight into how the genders are represented in the rhinologic literature. This study aimed to evaluate 11 years of literature to evaluate for gender differences in authorship position, collaborations, category and content of research, citations, and funding to gain perspective on how gender and authorship has changed over time., Methods: Authorship data for all articles on rhinologic subject matter published between January 1, 2008 and December 31, 2018 in four otolaryngology journals was collected. The gender of authors was determined by protocol. Category and content of research and funding status/source were additionally obtained., Results: Data were collected from 2666 articles. Gender of 14,510 authors was determined. Female authors accounted for 23% of the overall authors and male authors accounted for 77%. Female first authorship increased significantly over time, but there was no change in female senior authorship. The percentage of female authors steadily increased over time, whereas male authorship decreased slightly. Mixed gender teams were shown to be increasing in frequency. Women published more than expected in basic science and allergy and less than expected in skull base. On funded studies, women were significantly underrepresented as senior authors., Conclusion: This study represents the first assessment of gender differences in the rhinology literature. Areas where female representation can improve include senior authorship, increased involvement in skull base publications, and increased funding., (© 2021 ARS-AAOA, LLC.)
- Published
- 2021
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8. Reply to: Can we please reconsider intranasal injections in refractory sinonasal inflammatory disease?
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Halderman AA
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- Humans, Injections, Administration, Intranasal
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- 2021
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9. Fungal sinusitis: a spectrum of disease.
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Ma C, Ryan MW, Marple BF, and Halderman AA
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- Chronic Disease, Humans, Mycoses diagnosis, Rhinitis diagnosis, Rhinitis epidemiology, Sinusitis diagnosis
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- 2021
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10. Management of Sinusitis in the Cystic Fibrosis Patient.
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Okafor S, Kelly KM, and Halderman AA
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- Chronic Disease, Cystic Fibrosis complications, Cystic Fibrosis therapy, Endoscopy, Humans, Practice Guidelines as Topic, Quality of Life, Rhinitis complications, Rhinitis therapy, Sinusitis complications, Sinusitis therapy, Cystic Fibrosis diagnosis, Rhinitis diagnosis, Sinusitis diagnosis
- Abstract
Chronic rhinosinusitis (CRS) is present in up to 100% of patients with cystic fibrosis (CF). CF-associated CRS is particularly recalcitrant, and sinus disease can have important implications in the health of the lower airways and overall quality of life in these patients. Both medical and surgical management play important roles in treating CF-associated CRS, but guidelines are lacking. This review summarizes the current literature on both medical and surgical management of this disease to provide an up-to-date analysis and recommendations on the treatment of CF-associated CRS., Competing Interests: Disclosure The authors have nothing to disclose., (Copyright © 2019 Elsevier Inc. All rights reserved.)
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- 2020
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11. Is the gender gap closing in otolaryngology subspecialties? An analysis of research productivity.
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Okafor S, Tibbetts K, Shah G, Tillman B, Agan A, and Halderman AA
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- Efficiency, Female, Humans, Male, Medicine, Sex Distribution, Biomedical Research statistics & numerical data, Otolaryngology statistics & numerical data, Publishing statistics & numerical data
- Abstract
Objective: The proportion of women specializing in otolaryngology-head and neck surgery (Oto-HNS) and seeking fellowship training has steadily increased over the last several years. In academic Oto-HNS, gender differences exist in research productivity, scholarly impact, and funding. This study aims to evaluate gender differences in academic productivity between otolaryngologists in early, mid-, and later careers stages and within various subspecialties., Methods: Departmental websites for all Oto-HNS residency programs were accessed, and data including gender, academic rank, and fellowship training/subspecialty field was collected. Bibliometric data including h-index, publication years, number of citations, documents, and coauthors was obtained from the Scopus database. Career groups were defined as early (1-5 years), mid- (6-15 years), and later (16+ years). Continuous data was compared using the t test., Results: Data was collected on 1,754 academic otolaryngologists (412 women, 1,342 men). Overall, men exhibited significantly higher h-indices, number of documents, citations, and coauthors and actively published for more years compared to women (P < 0.0001 for all variables). Similar trends persisted across all subspecialties. When authors were broken down into career groups, women and men showed similar research productivity across all career groups in the subspecialties of otology, facial plastics, and rhinology; however, in head and neck, laryngology, and pediatrics, women continued to lag behind men., Conclusion: This study suggests that female otolaryngologists within certain subspecialties are keeping pace with their male counterparts in publication productivity in the early career time frame. This represents a change from prior studies which have shown women to be less productive in the early career period., Level of Evidence: NA Laryngoscope, 130:1144-1150, 2020., (© 2019 The American Laryngological, Rhinological and Otological Society, Inc.)
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- 2020
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12. Combined Microsurgical, Endovascular, and Endoscopic Approach to the Treatment of a Giant Vertebrobasilar Aneurysm.
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Plitt AR, Patel AR, McDougall CM, Halderman AA, Barnett SL, and Welch BG
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- Adult, Female, Humans, Treatment Outcome, Endovascular Procedures methods, Intracranial Aneurysm surgery, Microsurgery methods, Neuroendoscopy methods, Vertebrobasilar Insufficiency surgery
- Abstract
Background: Dolichoectasia is defined as elongation and dilatation of a blood vessel. In the intracranial circulation, the basilar artery is affected in 80% of cases. These are challenging lesions with an aggressive natural history, and treatment carries a relatively high rate of morbidity and mortality. We describe a case of multimodal treatment including endovascular, open microsurgical, and endoscopic endonasal approach (EEA) for management., Objective: To describe the technical nuance of the addition of the EEA for management of posterior circulation dolichoectasia., Methods: A 44-yr-old Hispanic woman with a 2-mo history of progressive headaches, gait disturbance, and lower cranial nerve dysfunction presented with acute neurologic decline. MRI demonstrated a dolichoectatic vertebrobasilar system with a giant 4.5-cm fusiform basilar aneurysm., Results: She underwent concomitant endovascular bilateral vertebral artery sacrifice with suction decompression and trapping by clip ligation distal to the lesion. Postoperatively, she developed symptomatic pontine compression. She was then taken for a transclival EEA for intra-aneurysmal thrombectomy. Thereafter, she made a significant functional recovery., Conclusion: The addition of endoscopic reconstruction to the treatment of a dolichoectatic basilar aneurysm is an operative nuance that can be employed in treating these highly morbid lesions. This case describing a multimodal treatment paradigm including EEA reconstruction can serve as an example for the future of treatment select cases of dolichoectasia of the vertebrobasilar complex., (Copyright © 2018 by the Congress of Neurological Surgeons.)
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- 2019
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13. Impact of high- versus low-risk genotype on sinonasal radiographic disease in cystic fibrosis.
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Halderman AA, Lee S, London NR, Day A, Jain R, Moore JA, and Lin SY
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- Adult, Cystic Fibrosis complications, Cystic Fibrosis diagnostic imaging, Female, Humans, Male, Mutation, Paranasal Sinuses diagnostic imaging, Retrospective Studies, Risk Factors, Young Adult, Cystic Fibrosis genetics, Cystic Fibrosis Transmembrane Conductance Regulator genetics, Genotype, Paranasal Sinus Diseases genetics, Tomography, X-Ray Computed statistics & numerical data
- Abstract
Objective: Understanding of how specific mutations impact the cystic fibrosis transmembrane conductance regulator (CFTR) protein has given rise to the classification of CF patients into low-risk and high-risk genotypes. Few prior studies have investigated differences in sinonasal disease between low-risk and high-risk CF genotypes. This multi-institutional review aimed to evaluate radiographic sinus disease severity based on genotype., Methods: A review was conducted on adult patients with CF evaluated between 2005 to 2017 at three academic institutions. Data including age, gender, CFTR mutation, and presence of a maxillofacial/sinus computed tomography scan was collected. A modified Lund-Mackay score (MLMS) was assigned to each scan, and the presence of sinus aplasia or hypoplasia was determined. Patients were further grouped depending on genotype into low- or high-risk for comparison., Results: A total of 126 patients were included with 99 patients in the high-risk and 21 in the low-risk groups. The high-risk group had significantly higher MLMS than the low-risk group (mean 13.88 vs. 8.06, P < 0.0001, 95% CI -8.196 to -3.462) The rate of frontal (P < 0.01), maxillary (P = 0.04), and sphenoid (P < 0.001) hypoplasia/aplasia was significantly higher in high-risk patients compared to low-risk., Conclusion: This is one of the largest studies to date evaluating the impact of CF genotype on paranasal sinus development and disease. Genotype appears to impact sinonasal disease severity and also potentially paranasal sinus cavity development to a degree, although the exact mechanism is unknown., Level of Evidence: 4 Laryngoscope, 129:788-793, 2019., (© 2018 The American Laryngological, Rhinological and Otological Society, Inc.)
- Published
- 2019
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14. Bevacizumab for Epistaxis in Hereditary Hemorrhagic Telangiectasia: An Evidence-based Review.
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Halderman AA, Ryan MW, Marple BF, Sindwani R, Reh DD, and Poetker DM
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- Animals, Epistaxis etiology, Epistaxis immunology, Evidence-Based Medicine, Humans, Randomized Controlled Trials as Topic, Telangiectasia, Hereditary Hemorrhagic complications, Telangiectasia, Hereditary Hemorrhagic immunology, Vascular Endothelial Growth Factor A immunology, Angiogenesis Inhibitors therapeutic use, Bevacizumab therapeutic use, Epistaxis prevention & control, Immunotherapy methods, Telangiectasia, Hereditary Hemorrhagic therapy
- Abstract
Objective Epistaxis is a primary complaint in 90% to 96% of patients with hereditary hemorrhagic telangiectasia (HHT). Numerous surgical and medical treatments aim to decrease the frequency and severity of epistaxis in this patient population. Bevacizumab is a recombinant, humanized monoclonal antibody to vascular endothelial growth factor, an angiogenic factor elevated in HHT. It has been used in several forms to treat epistaxis in HHT but thus far, evidence-based recommendations are limited. Study Design Systematic review with evidence-based recommendations. Methods A systematic review of the literature following Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines was performed using Embase, MEDLINE, MEDLINE In-Process/Epub, and Cochrane databases. English language abstracts were reviewed for relevance. Results Eleven manuscripts met inclusion criteria and were analyzed. Submucosal injection, submucosal injection plus laser coagulation, intravenous (IV), and topical formulations of bevacizumab were evaluated for their therapeutic impact on epistaxis in patients with HHT. Three randomized controlled trials failed to show topical bevacizumab to be more effective in controlling epistaxis than saline or other moisturizers. Conclusions The use of submucosal and IV bevacizumab shows promise, but further study is necessary to determine the true efficacy in the treatment of epistaxis as only grade C level exists currently. Based on the available literature, the use of topical bevacizumab is not recommended (grade B).
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- 2018
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15. Medical treatment of epistaxis in hereditary hemorrhagic telangiectasia: an evidence-based review.
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Halderman AA, Ryan MW, Clark C, Sindwani R, Reh DD, Poetker DM, Invernizzi R, and Marple BF
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- Administration, Oral, Administration, Topical, Angiogenesis Inhibitors therapeutic use, Epistaxis etiology, Estriol administration & dosage, Estrogen Replacement Therapy methods, Evidence-Based Medicine, Female, Humans, Male, Recurrence, Selective Estrogen Receptor Modulators therapeutic use, Thalidomide therapeutic use, Tranexamic Acid therapeutic use, Epistaxis drug therapy, Telangiectasia, Hereditary Hemorrhagic complications
- Abstract
Background: Hereditary hemorrhagic telangiectasia (HHT) is an autosomal dominant hereditary disorder resulting in vascular dysplasia and formation of arteriovenous malformations. Recurrent epistaxis is a hallmark of the disease. An array of medical therapies are used in this patient population, but robust evidence-based recommendations regarding the medical treatment of epistaxis are lacking. This systematic review was performed to look at the current literature and make meaningful evidence-based recommendations., Methods: A search of the Ovid MEDLINE, Embase, and Cochrane databases was conducted by a research librarian. Abstracts in the English language and published in a peer-review journal were reviewed for relevance and inclusion. PRISMA guidelines were followed., Results: Eighteen studies met the inclusion criteria. In a few small studies, thalidomide was shown to consistently improve severity and frequency of epistaxis and improve hemoglobin concentrations while decreasing the need for transfusion. Tranexamic acid appeared to only impact the epistaxis severity score and not other clinical outcomes. Selective estrogen modulators (SERMs), propranolol, rose geranium oil, and N-acetylcysteine, have demonstrated promising efficacy in small trials., Conclusion: Appropriate medical therapies for epistaxis outcomes in HHT remain undefined, and there is no "gold standard." Many of the studies are small and the data reported are heterogeneous, and therefore the ability to make strong evidence-based recommendations is limited. However, many different medications appear to be promising options., (© 2018 ARS-AAOA, LLC.)
- Published
- 2018
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16. The Role of Allergy in Chronic Rhinosinusitis.
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Halderman AA and Tully LJ
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- Chronic Disease, Humans, Hypersensitivity therapy, Immunoglobulin E immunology, Immunotherapy, Rhinitis, Allergic microbiology, Rhinitis, Allergic therapy, Sinusitis therapy, Th2 Cells immunology, Hypersensitivity complications, Mycoses complications, Nasal Polyps complications, Rhinitis, Allergic complications, Sinusitis etiology
- Abstract
The role of allergy in chronic rhinosinusitis (CRS) has long been debated and remains controversial. The 2 diseases frequently co-occur; however, direct causality has never been proved. The literature is largely mixed as to the manner and degree by which allergy contributes to CRS and this is in large part due to heterogeneity in the definitions of allergy and of CRS. In this review, the potential role of allergy in the disease processes of CRS without polyps, CRS with polyps, and allergic fungal rhinosinusitis is discussed., (Copyright © 2017 Elsevier Inc. All rights reserved.)
- Published
- 2017
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17. Organism and Microbiome Analysis: Techniques and Implications for Chronic Rhinosinusitis.
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Halderman AA and Lane AP
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- Bacteria classification, Bacteria genetics, Chronic Disease, High-Throughput Nucleotide Sequencing, Humans, Metagenome genetics, RNA, Ribosomal, 16S genetics, Microbiota, Paranasal Sinuses microbiology, Rhinitis microbiology, Sinusitis microbiology
- Abstract
Modern advances in DNA sequencing have allowed for the development of culture-independent techniques with application to infectious and inflammatory conditions, such as rhinosinusitis. Although paradigm-changing discoveries have resulted from molecular microbiologic methods for a number of diseases, insights provided into the role of bacteria in chronic rhinosinusitis have yet to be fully understood to the point of impacting clinical diagnosis and management. As culture-independent techniques continue to evolve and become more refined, it is likely that a better understanding will emerge of how the microbiome influences chronic rhinosinusitis pathogenesis and response to therapy., (Copyright © 2017 Elsevier Inc. All rights reserved.)
- Published
- 2017
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18. F508del genotype in endoscopic sinus surgery: do differences in outcomes exist between genotypic subgroups?
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Halderman AA, West N, Benke J, Roxbury CR, and Lin SY
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- Adolescent, Adult, Chronic Disease, Endoscopy, Female, Genotype, Humans, Male, Nasal Surgical Procedures, Respiratory Function Tests, Rhinitis genetics, Rhinitis surgery, Sinusitis genetics, Sinusitis surgery, Treatment Outcome, Young Adult, Cystic Fibrosis genetics, Cystic Fibrosis surgery, Cystic Fibrosis Transmembrane Conductance Regulator genetics, Paranasal Sinuses surgery
- Abstract
Background: The impact of endoscopic sinus surgery (ESS) on pulmonary function in cystic fibrosis (CF) patients with chronic rhinosinusitis remains unclear, as studies have demonstrated conflicting results. To date, no study has looked specifically at the impact of CF genotype on lung function after ESS. In this study, we reviewed changes in pulmonary function test (PFT) results after ESS in F508del homozygotes and heterozygotes., Methods: The charts of 25 patients with CF without prior lung transplant, who underwent ESS performed by the same surgeon between the period of July 2005 to July 2015, were retrospectively reviewed. Data including genotype and PFT results were collected. Patients were grouped based on genotype. Pre- and postoperative PFTs were compared., Results: Some differences in PFT outcomes after ESS could be seen on subgroup analyses. For example, when considered as a whole group, the overall cohort showed a significant improvement from preoperative FEV
1 levels at 6 months after surgery (p = 0.0127). Interestingly, on subgroup analysis, the heterozygous group saw significant improvements from preoperative FEV1 levels at 6 and 12 months (p = 0.0155 and p = 0.0333, respectively). No significant improvements were seen from "baseline" FEV1 in either group at any timepoint., Conclusion: Prior studies investigating the impact of ESS on pulmonary function in CF patients have shown conflicting results. To our knowledge, those earlier udies did not separate and compare different genotypes, which may have introduced heterogeneity in their patient populations. Our study suggests that grouping CF patients more strictly according to genotype or disease severity when investigating outcomes may reveal differences among various subgroups., (© 2017 ARS-AAOA, LLC.)- Published
- 2017
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19. Reversal of cigarette smoke extract-induced sinonasal epithelial cell barrier dysfunction through Nrf2 Activation.
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Tharakan A, Halderman AA, Lane AP, Biswal S, and Ramanathan M Jr
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- Adult, Aged, Cell Adhesion Molecules metabolism, Cells, Cultured, Ethmoid Sinus surgery, Female, Humans, Lipopolysaccharide Receptors genetics, Male, Middle Aged, RNA, Messenger metabolism, Receptors, Cell Surface metabolism, Respiratory Mucosa metabolism, Toll-Like Receptor 2 genetics, Young Adult, Zonula Occludens-1 Protein metabolism, beta-Defensins genetics, Epithelial Cells metabolism, NF-E2-Related Factor 2 metabolism, Smoke, Nicotiana
- Abstract
Background: Environmental factors such as inhaled pollutants like cigarette smoke may play a significant role in diseases of the upper airway including chronic rhinosinusitis (CRS). Recent studies have shown that cigarette smoke causes impaired airway epithelial cell barrier function likely through environmental oxidative stress related pathways. The purpose of this study is to explore whether enhancing nuclear factor erythroid 2 [NF-E2]-related factor 2 [Nrf2], the body's master antioxidant system, can ameliorate cigarette smoke-induced sinonasal epithelial cell (SNEC) barrier dysfunction., Methods: Human SNECs (HSNECs) were grown from control patients at the air-liquid interface (ALI). HSNECs were stimulated with cigarette smoke extract (CSE) with and without pharmacologic activation of Nrf2. HSNECs were then stained for the epithelial cell junctional proteins zonula occludens 1 (ZO-1) and junctional adhesion molecule A (JAM-A) using confocal microscopy. In addition, transepithelial electrical resistance (TER) was measured in cultures before and after stimulation with CSE., Results: CSE stimulation caused a global disruption of the epithelial junctional proteins ZO-1 and JAM-A along with an associated decrease in TER levels. Enhancing Nrf2 levels prior to stimulation with CSE was associated with increased localization of ZO-1 and JAM-A levels at the cell surface and statistically significant increases in TER levels., Conclusion: This is the first study to demonstrate that cigarette smoke induced SNEC barrier dysfunction is reversible by Nrf2 activation. The Nrf2 antioxidant pathway may represent a potential therapeutic target for cigarette smoke-associated sinonasal inflammation., (© 2016 ARS-AAOA, LLC.)
- Published
- 2016
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20. The effect of middle turbinate resection on topical drug distribution into the paranasal sinuses.
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Halderman AA, Stokken J, and Sindwani R
- Subjects
- Administration, Intranasal, Coloring Agents administration & dosage, Endoscopy, Fluorescein administration & dosage, Fluorescein pharmacokinetics, Humans, Methylene Blue administration & dosage, Methylene Blue pharmacokinetics, Nebulizers and Vaporizers, Quaternary Ammonium Compounds administration & dosage, Quaternary Ammonium Compounds pharmacokinetics, Coloring Agents pharmacokinetics, Paranasal Sinuses metabolism, Turbinates surgery
- Abstract
Background: During sinus surgery, partial or complete resection of the middle turbinate (MT) is sometimes necessary because of polypoid changes or demineralization. Topical drug delivery to the paranasal sinuses is an integral component in managing chronic rhinosinusitis (CRS) with and without nasal polyposis. The purpose of this study was to examine the role of the MT and MT resection in topical drug distribution into the sinuses via nebulization. We report on a novel technique of quantitatively evaluating the delivery of nebulized dye in cadavers., Methods: Endoscopic sinus surgery was performed on 5 fresh cadavers. Complementary colored dyes mixed with saline were successively nebulized using the following protocol: (1) fluorescein prior to MT resection; (2) brilliant green following partial MT resection; and (3) methylene blue following total MT resection. Photodocumentation of the sinuses was performed following each nebulization and standardized photoanalysis was performed., Results: Successive nebulizations with fluorescein, brilliant green, and methylene blue produced a complementary staining pattern that provided an easy side-by-side analysis of the extent of mucosal staining. Dye delivery to the frontal and sphenoid sinuses significantly increased following partial resection of the MT (p = 0.013 and p = 0.0027, respectively) and complete resection of the MT (p = 0.027 and p = 0.027, respectively). Following complete MTR, dye delivery to the maxillary sinus significantly increased compared to baseline (MT intact) (p = 0.0027)., Conclusion: Resection of the MT appears to have a significant effect on nebulized drug delivery into the frontal, maxillary, and sphenoid sinuses. Future prospective studies will help delineate the clinical relevance of this effect., (© 2016 ARS-AAOA, LLC.)
- Published
- 2016
- Full Text
- View/download PDF
21. Variation in Delivery of Sinus Surgery in the Medicaid Population across Ethnicities.
- Author
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Woodard T, Sindwani R, Halderman AA, Holy CE, and Gurrola J 2nd
- Subjects
- Adolescent, Adult, Aged, Aged, 80 and over, Child, Female, Health Services Accessibility, Humans, Male, Medicaid, Middle Aged, Retrospective Studies, United States epidemiology, Endoscopy methods, Paranasal Sinus Diseases ethnology, Paranasal Sinus Diseases surgery, Practice Patterns, Physicians' statistics & numerical data
- Abstract
Objective: To evaluate differences in sinus surgery rates in the US Medicaid population by ethnicities., Study Design: Retrospective administrative database analysis., Setting: US-based outpatient settings., Methods: All patients from the MarketScan Medicaid database with endoscopic sinus surgery from 2009 to 2013 were stratified by ethnicity, age (5-year increments, as per US Census), and sex. Crude rates of endoscopic sinus surgery per age group and sex were compiled for all patients and each ethnic group (African American, Caucasian, Hispanics, and others). Age and sex standardization was done with the MarketScan Medicaid overall population as standard. The coefficient of variation, extremal ratio, and chi-square statistics were calculated to determine variation across ethnicities., Results: Overall sinus surgery rates per 1000 people in the Medicaid population ranged from 0.36 to 0.40 from 2009 to 2013 (African Americans: 0.24-0.26; Hispanics: 0.21-0.37; Caucasians: 0.47-0.56; rate of surgery statistically lower for African American vs Hispanics for 4 of 5 years). The coefficient of variation and extremal ratio ranged from 29.3% to 45.6% and 1.98 to 2.6, respectively. Differences among groups were significant for all years (P < .0001). Comparison of sex-adjusted ratios by age group demonstrated greater rates of surgery in the Caucasian group versus other groups for all age categories., Conclusion: The Medicaid database was selected for this analysis to eliminate payer and wealth as potential confounders in access to health care. Despite this approach, significant differences in surgery rates among ethnic groups were observed. Further research is critical to understand those differences and provide actionable and effective recommendations for change., (© American Academy of Otolaryngology—Head and Neck Surgery Foundation 2016.)
- Published
- 2016
- Full Text
- View/download PDF
22. Immunomodulators in the Treatment of Nasal Polyposis.
- Author
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Halderman AA and Lane AP
- Subjects
- Chronic Disease, Humans, Rhinitis drug therapy, Sinusitis drug therapy, Immunologic Factors therapeutic use, Nasal Polyps drug therapy
- Abstract
The inflammatory mechanisms that contribute to chronic rhinosinusitis with nasal polyps (CRSwNP) are complex. In the past, medical options for treating CRSwNP have been limited. Emerging classes of immunomodulators such as omalizumab, anti-leukotrienes, anti-IL-4, anti-IL-5, and recognition of the modulating effects of macrolides have shown promising results in the treatment of CRSwNP. Ultimately, large randomized controlled trials are necessary to establish the efficacy of these medications but for now, the area of medical immunomodulators remains an exciting frontier., (© 2016 S. Karger AG, Basel.)
- Published
- 2016
- Full Text
- View/download PDF
23. Hemorrhagic Complications of Endoscopic Sinus Surgery.
- Author
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Halderman AA, Sindwani R, and Woodard TD
- Subjects
- Humans, Postoperative Complications etiology, Endoscopy adverse effects, Epistaxis etiology, Paranasal Sinuses surgery, Postoperative Complications prevention & control, Postoperative Hemorrhage epidemiology
- Abstract
Major complications during endoscopic sinus surgery are rare and occur in 0.36% to 3.1% of patients. Postoperative hemorrhage accounts for 23% to 39% of complications. Despite being rare, major hemorrhage can be serious for the patient. This article discusses hemorrhagic complications during and following endoscopic sinus surgery, focusing on a review of the surgical anatomy, common pitfalls to avoid, preventative measures, and management of certain catastrophic complications for which preparedness can mean the difference between life and death., (Copyright © 2015 Elsevier Inc. All rights reserved.)
- Published
- 2015
- Full Text
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24. Attitudes on and usage of balloon catheter technology in rhinology: A survey of the American Rhinologic Society.
- Author
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Halderman AA, Stokken J, Momin SR, Smith TL, and Sindwani R
- Subjects
- Catheterization methods, Endoscopy, Humans, Internet, United States, Attitude of Health Personnel, Catheterization statistics & numerical data, Otolaryngology, Paranasal Sinus Diseases therapy, Practice Patterns, Physicians', Societies, Medical, Surveys and Questionnaires
- Abstract
Introduction: Use of balloon catheter dilation in the management of paranasal sinus diseases, including chronic rhinosinusitis (CRS) and recurrent acute rhinosinusitis, remains controversial. In an effort to gain some clarity about its evolving role, we surveyed members of the American Rhinologic Society (ARS)., Method: Online survey., Results: ARS Members were sent an invitation by e-mail to participate in an online, anonymous 23-item survey. A total of 231 participants completed the survey, for an overall response rate of 25%. Balloon catheter technology (BCT) played no role in the practices of one-third of all the respondents. Of those who did use BCT, more than 50% performed only 1-4 cases per month on average. This did not differ significantly with practice type (p = 0.2988). The overall use of BCT differed between types of practices with those in private practice reporting greater use of the technology for maxillary and sphenoid sinuses (p = 0.0003 and p = 0.0073, respectively). Participants in private practice appeared significantly more impressed with the results of BCT when compared with those in academia (p = 0.0005) and also thought that patients were more satisfied (p = 0.0002). Opinions toward the strength of available evidence also differed significantly between the two groups (p = 0.0007). Thirty-two respondents had experienced a complication with BCT, although the majority of these did not require any intervention., Conclusions: ARS members surveyed used BCT infrequently in their practices. Attitudes on the role of this technology in CRS management differed between academic and private practitioners, but, despite this, the volume of reported BCT use was the same. Surgeons are more accepting of the technology now compared with 5 years ago, and many of them believe that their use of BCT will increase in the future.
- Published
- 2015
- Full Text
- View/download PDF
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