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Your search keyword '"Luisa Abbagnato"' showing total 2 results
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2 results on '"Luisa Abbagnato"'

1. Epidemiology, Clinical Features and Prognostic Factors of Pediatric SARS-CoV-2 Infection: Results From an Italian Multicenter Study

Author

Silvia Garazzino, Andrea Lo Vecchio, Luca Pierantoni, Francesca Ippolita Calò Carducci, Federico Marchetti, Antonella Meini, Elio Castagnola, Gianluca Vergine, Daniele Donà, Samantha Bosis, Icilio Dodi, Elisabetta Venturini, Enrico Felici, Roberta Giacchero, Marco Denina, Luca Pierri, Giangiacomo Nicolini, Carlotta Montagnani, Andrzej Krzysztofiak, Sonia Bianchini, Caterina Marabotto, Pier-Angelo Tovo, Giulia Pruccoli, Marcello Lanari, Alberto Villani, Guido Castelli Gattinara, The Italian SITIP-SIP Pediatric Infection Study Group, Valeria Caldarelli, Filippo Maria Salvini, Giovanni Corsello, Barba Paolo Del, Paola Berlese, Carlo Agostoni, Chiara Ghizzi, Vera Quadri, Sara Riscassi, Ivana Rabbone, Carmelina Calitri, Luisa Abbagnato, Luciana Parola, Giuseppe Banderali, Ilaria Pacati, Simonetta Cherubini, Paola Lippi, Andrea Guala, Rino Agostiniani, Salvatore Cazzato, Ahmad Kantar, Luca Baroero, Nadia Rossi, Cristina Dalmazzo, Laura Panigati, Paolo Manzoni, Alessandro Vigo, Ludovica Fiore, Pasquale Comberiati, Gianna Battezzati, Paola Verna, Gianluca Tornese, Paola Gianino, Luca Bertacca, Angelina Vaccaro, Giorgio Zavarise, Luigi Marchione, Paola Gallia, Paola Di Filippo, Chiara Centenari, Alessandra Iacono, Alessandro Plebani, Marta Ferretti, Sara Rizzi, Sara Rossin, Paola Marchisio, Alessandro De Fanti, Costantino De Giacomo, Giuliana Ferrante, Graziano Barera, Pajno Roberta, Stefano Martelossi, Alessia Rocchi, Rosa Francavilla, Valin Paola Sogno, Marco Poeta, Piero Valentini, Raffaele Papa, Anna Maria Magistà, Raffaele Badolato, Carolina Saffioti, Maria Cristina Greco, Paola Costenaro, Maria Di Pietro, Susanna Esposito, Giovanni Pieri, Maria Valentina Spartà, Valentina Maffini, Laura Cursi, Francesco Nunziata, Federica Mignone, Claudia Bondone, Giacomo Stera, Agostina Marolda, Lorenzo Fiorica, Caterina Sabatini, Maria Rita Genovese, Cristina Ferrari, and Luisa Galli

Subjects
SARS-CoV-2 infection, children, multisystem inflammatory syndrome, MIS-C, COVID-19, Pediatrics, RJ1-570
Abstract

Background: Many aspects of SARS-CoV-2 infection in children and adolescents remain unclear and optimal treatment is debated. The objective of our study was to investigate epidemiological, clinical and therapeutic characteristics of pediatric SARS-CoV-2 infection, focusing on risk factors for complicated and critical disease.Methods: The present multicenter Italian study was promoted by the Italian Society of Pediatric Infectious Diseases, involving both pediatric hospitals and general pediatricians/family doctors. All subjects under 18 years of age with documented SARS-CoV-2 infection and referred to the coordinating center were enrolled from March 2020.Results: As of 15 September 2020, 759 children were enrolled (median age 7.2 years, IQR 1.4; 12.4). Among the 688 symptomatic children, fever was the most common symptom (81.9%). Barely 47% of children were hospitalized for COVID-19. Age was inversely related to hospital admission (p < 0.01) and linearly to length of stay (p = 0.014). One hundred forty-nine children (19.6%) developed complications. Comorbidities were risk factors for complications (p < 0.001). Viral coinfections, underlying clinical conditions, age 5–9 years and lymphopenia were statistically related to ICU admission (p < 0.05).Conclusions: Complications of COVID-19 in children are related to comorbidities and increase with age. Viral co-infections are additional risk factors for disease progression and multisystem inflammatory syndrome temporarily related to COVID-19 (MIS-C) for ICU admission.

Published
2021
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2. Pediatric Tuberculosis in Italian Children: Epidemiological and Clinical Data from the Italian Register of Pediatric Tuberculosis

Author

Alberto Villani, Patrizia Ballista, Luisa Galli, Laura Castiglioni, Elena Chiappini, Daniele Le Serre, Samantha Bosis, Gian Luigi Marseglia, Maurizio de Martino, Giuseppe Losurdo, Laura Lancella, Maria Di Gangi, Filippo Salvini, Cristina Venturelli, Andrea Lo Vecchio, Barbara Maria Bergamini, Eugenia Bruzzese, Elena Boccuzzi, Caterina Marabotto, Susanna Esposito, Michele Pinon, Piero Valentini, Laura Cursi, Elisa Fiumana, Elio Castagnola, Grazia Bossi, Marco Montesanti, Francesca Maschio, Chiara Fornabaio, Giulia Tosetti, Elisabetta Venturini, Alfredo Guarino, Margherita Codifava, Gabriella Bottone, Icilio Dodi, Rita Grandolfo, Carla Lupi, Nicola Palladino, Mariella Valenzise, Raffaele Domenici, V. Portelli, Danilo Buonsenso, Valentina Fiorito, Barbara Vecchi, Luisa Abbagnato, Pier-Angelo Tovo, Enrica Riva, Silvia Garazzino, Chiara Tersigni, Galli, L, Lancella, L, Tersigni, C, Venturini, E, Chiappini, E, Bergamini, Bm, Codifava, M, Venturelli, C, Tosetti, G, Marabotto, C, Cursi, L, Boccuzzi, E, Garazzino, S, Tovo, Pa, Pinon, M, Le Serre, D, Castiglioni, L, LO VECCHIO, Andrea, Guarino, Alfredo, Bruzzese, Eugenia, Losurdo, G, Castagnola, E, Bossi, G, Marseglia, Gl, Esposito, S, Bosis, S, Grandolfo, R, Fiorito, V, Valentini, P, Buonsenso, D, Domenici, R, Montesanti, M, Salvini, Fm, Riva, E, Dodi, I, Maschio, F, Abbagnato, L, Fiumana, E, Fornabaio, C, Ballista, P, Portelli, V, Bottone, G, Palladino, N, Valenzise, M, Vecchi, B, Di Gangi, M, Lupi, C, Villani, A, and de Martino, M.

Subjects
Male, Pediatrics, Children, Italian, Register, Tuberculosis, Antitubercular Agents, Drug resistance, Ambulatory Care Facilities, Catalysi, lcsh:Chemistry, 0302 clinical medicine, Health care, Epidemiology, Tuberculosis, Multidrug-Resistant, 030212 general & internal medicine, Registries, Child, lcsh:QH301-705.5, Spectroscopy, Pediatric, register, biology, Incidence (epidemiology), Computer Science Applications1707 Computer Vision and Pattern Recognition, Pulmonary, General Medicine, Multidrug-Resistant, Hospitals, Pediatric, Settore MED/38, Hospitals, Computer Science Applications, Pediatric tuberculosis, Settore MED/38 - PEDIATRIA GENERALE E SPECIALISTICA, Italy, tuberculosis, Child, Preschool, Catalysis, Molecular Biology, Physical and Theoretical Chemistry, Organic Chemistry, Inorganic Chemistry, Female, medicine.medical_specialty, Adolescent, Tuberculosi, Humans, Infant, Tuberculosis, Pulmonary, Article, Mycobacterium tuberculosis, 03 medical and health sciences, children, 030225 pediatrics, medicine, Preschool, business.industry, Public health, medicine.disease, biology.organism_classification, Children, Italian, Register, Tuberculosis, lcsh:Biology (General), lcsh:QD1-999, business
Abstract

Tuberculosis (TB) is one of the leading causes of death worldwide. Over the last decades, TB has also emerged in the pediatric population. Epidemiologic data of childhood TB are still limited and there is an urgent need of more data on very large cohorts. A multicenter study was conducted in 27 pediatric hospitals, pediatric wards, and public health centers in Italy using a standardized form, covering the period of time between 1 January 2010 and 31 December 2012. Children with active TB, latent TB, and those recently exposed to TB or recently adopted/immigrated from a high TB incidence country were enrolled. Overall, 4234 children were included; 554 (13.1%) children had active TB, 594 (14.0%) latent TB and 3086 (72.9%) were uninfected. Among children with active TB, 481 (86.8%) patients had pulmonary TB. The treatment of active TB cases was known for 96.4% (n = 534) of the cases. Overall, 210 (39.3%) out of these 534 children were treated with three and 216 (40.4%) with four first-line drugs. Second-line drugs where used in 87 (16.3%) children with active TB. Drug-resistant strains of Mycobacterium tuberculosis were reported in 39 (7%) children. Improving the surveillance of childhood TB is important for public health care workers and pediatricians. A non-negligible proportion of children had drug-resistant TB and was treated with second-line drugs, most of which are off-label in the pediatric age. Future efforts should concentrate on improving active surveillance, diagnostic tools, and the availability of antitubercular pediatric formulations, also in low-endemic countries.

Published
2016

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