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2. General Parity between Trio and Pairwise Breeding of Laboratory Mice in Static Caging

Author

William J. Janssen, Katsuyuki Takeda, John C. Cambier, Christine Delgado, Laurel L. Lenz, Derek L Fong, Margaret Cruse, Willi K. Born, Katherine Haskins, Stijn De Langhe, Ross M. Kedl, Julia Granowski, Claudia Jakubzick, Beata Kosmider, Randal C. Klumm, Matthew D. Rosenbaum, Douglas Curran-Everett, Hua Huang, Lawrence J. Wysocki, Jennifer A. Kench, Thomas J. Stranova, Saigiridhar Tummala, and Lisa A. Switzer

Subjects
Male, Gerontology, business.industry, Body Weight, Immunology, Institutional Animal Care and Use Committee, Autoimmunity, Guidelines as Topic, Mice, Transgenic, Breeding, Body weight, Housing, Animal, Article, Mice transgenic, Mice, Pup survival, Pregnancy, Animals, Immunology and Allergy, Medicine, Female, Pairwise comparison, Lymphocytes, business
Abstract

Changes made in the 8th edition of the Guide for the Care and Use of Laboratory Animals included new recommendations for the amount of space for breeding female mice. Adopting the new recommendations required, in essence, the elimination of trio breeding practices for all institutions. Both public opinion and published data did not readily support the new recommendations. In response, the National Jewish Health Institutional Animal Care and Use Committee established a program to directly compare the effects of breeding format on mouse pup survival and growth. Our study showed an overall parity between trio and pairwise breeding formats on the survival and growth of the litters, suggesting that the housing recommendations for breeding female mice as stated in the current Guide for the Care and Use of Laboratory Animals should be reconsidered.

Published
2014

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