36 results on '"Mariana Agostini de Moraes"'
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2. Influence of Guluronic and Mannuronic Groups in Sodium Alginate Blends with Silk Fibroin: Phase Equilibrium and Thermodynamic Modeling
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Laise Maia Lopes, Mariana Agostini de Moraes, and Marisa Masumi Beppu
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Polymers and polymer manufacture ,TP1080-1185 - Abstract
Silk fibroin (SF) and sodium alginate (SA) are natural polymers with interesting properties to produce biomaterials. Blends of these polymers form a complex protein–polysaccharide system where phase separation can be observed. Therefore, the thermodynamic analysis of this system is important to understand the interaction between the polymers and predict the final state and composition of the phases found in these blends. This study explored blends with a different initial composition of SF, SA, and water at 25°C and neutral pH. The influence of the proportion between mannuronic and guluronic acids on SA composition was investigated. After phase separation, two phases were identified, and the equilibrium data were fitted on three different thermodynamic models: Flory–Huggins, non-random two-liquids, and universal quasichemical. Cohn equation was also used to investigate the potential of SA to precipitate the SF in solution. The results show that the proportion of mannuronic and guluronic acids on the SA can significantly influence on equilibrium data and on the SF/SA interaction parameter, hence, becoming a variability factor if this parameter is not under control in formulations. more...
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- 2023
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Catalog
3. Phase Diagram and Estimation of Flory-Huggins Parameter of Interaction of Silk Fibroin/Sodium Alginate Blends
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Laise Maia Lopes, Mariana Agostini de Moraes, and Marisa Masumi Beppu
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silk fibroin ,sodium alginate ,phase separation ,blends ,thermodynamic ,biomaterials ,Biotechnology ,TP248.13-248.65 - Abstract
Silk fibroin (SF) and sodium alginate (SA) are natural polymers used to produce biomaterials. One of the strategies to improve the properties of these products is to prepare blends with them, which are partially miscible. Phase separation is observed, therefore, the thermodynamic analysis of this system is important to predict the final state and composition of this blends. This study explored blends with a different initial composition of SF, SA, and water (WA) at 25°C and neutral pH. After phase separation, two phases were identified, one rich in SF and other rich in SA. The Flory-Huggins parameters of interaction of polymer-solvent and polymer-polymer were estimated using the extended equation and data of phase equilibrium, their values indicates the partial miscibility of the polymers. more...
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- 2020
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4. Thermal modification and oxidation of cassava starch to produce biodegradable films
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Isabella de Lima Oliveira, Lucas de Souza Falcão, Pedro Henrique Campelo, and Mariana Agostini de Moraes
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Mechanics of Materials ,Mechanical Engineering ,General Materials Science ,Condensed Matter Physics - Published
- 2023
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5. Combinatorial effect of pH and ionic strength in the release of charged dyes from silk fibroin membranes
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José Armando Bertolini Neto, Luisa Storelli dos Reis, Bruno Thorihara Tomoda, and Mariana Agostini de Moraes
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General Materials Science - Published
- 2022
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6. Gelatin-based nanosystems for therapeutic applications
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Douglas Barbieri, Raquel de Melo Barbosa, Patricia Severino, Eliana B. Souto, Mariana Agostini de Moraes, and Classius Ferreira da Silva
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- 2023
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7. List of contributors
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Ahmed S. Abo Dena, Urba Afnan, Shirin Ahmadi, Fahad Akhtar, Tejraj M. Aminabhavi, Nafiu Aminu, Siti Nor Syairah Anis, Sadiya Anjum, Md Aquib, Akmal M. Asrorov, Evren Atlihan-Gundogdu, Momoh Mumuni Audu, Abul Kalam Azad, Douglas Barbieri, Shrinath Bhat, Tanima Bhattacharya, Sabeerabi Bonala, Amir Bzainia, Liew Wen Ching, Mário Rui P.F.N. Costa, Pooja Da Bidla, Classius Ferreira da Silva, Raquel de Melo Barbosa, Mariana Agostini de Moraes, Rolando C.S. Dias, Ibrahim M. El-Sherbiny, Shohreh Fahimirad, Mohammad Fahimizadeh, Muhammad Asim Farooq, Marziyeh Fathi, Jiaur R. Gayen, Catarina P. Gomes, Shagufta Haque, Najmul Hasan, Md Saquib Hasnain, Athar Husain, Rashid Ilmi, Purnima Jain, Sanjay K. Jain, Abhishek Jha, Mohamed Fawzy Kabil, Merve Karpuz, Nozieana Khairuddin, Amari Mohamed Khamis, Sidra Khatoon, Manish Kumar, Vijay Kumar, Mahaveer D. Kurkuri, Perpetua Takunda Kutoka, Jaya Lakkakula, Nurul Asmak Mohd Lazim, Karla Martinez-Robinson, Brahmeshwar Mishra, Anwesha Mohapatra, Aishah binti Mohd Marsin, Ida Idayu Muhamad, Akhil Nair, Amit Kumar Nayak, Peter M. Ndangili, Naumih M. Noah, Yadollah Omidi, Emre Ozgenc, Pritish Kumar Panda, Poonam Parashar, Kamla Pathak, Chitta Ranjan Patra, Norhayati Pa’e, Sarjana Raikwar, Aravind Kumar Rengan, Mohammad Irshad Reza, Sri Amruthaa Sankaranarayanan, Shivani Saraf, Anjana Sarkar, Rakesh Sehgal, Suguna Selvakumaran, Zeynep Senyigit, Patricia Severino, Bhasha Sharma, Kashma Sharma, Shreya Sharma, Shashank Shekhar, Saeed Shojaee, Pragati Singh, Muhammad Sohail, Eliana B. Souto, Anees Ahmed Syed, Joash Ban Lee Tan, Garima Tripathi, U.T. Uthappa, Amit Verma, Nilesh S. Wagh, Dickson Pius Wande, Bo Wang, and Li Wen Wong more...
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- 2023
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8. A review on orally disintegrating films (ODFs) made from natural polymers such as pullulan, maltodextrin, starch, and others
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Murilo Santos Pacheco, Mariana Agostini de Moraes, Douglas E. Barbieri, and Classius Ferreira da Silva
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food.ingredient ,Starch ,Film-forming agent ,02 engineering and technology ,Polysaccharide ,Biochemistry ,Gelatin ,Chitosan ,03 medical and health sciences ,chemistry.chemical_compound ,food ,Polysaccharides ,Structural Biology ,Humans ,Glucans ,Molecular Biology ,030304 developmental biology ,chemistry.chemical_classification ,Drug Carriers ,0303 health sciences ,Polymer science ,food and beverages ,Membranes, Artificial ,Pullulan ,General Medicine ,Polymer ,021001 nanoscience & nanotechnology ,Maltodextrin ,chemistry ,0210 nano-technology - Abstract
In recent years, orally disintegrating films (ODFs) have been studied as alternative ways for drug administration. They can easily be applied into the mouth and quickly disintegrate, releasing the drug with no need of water ingestion and enabling absorption through the oral mucosa. The ODFs matrices are typically composed of hydrophilic polymers, in which the natural polymers are highlighted since they are polymers extracted from natural sources, non-toxic, biocompatible, biodegradable, and have favorable properties for this application. Besides that, natural polymers such as polysaccharides and proteins can be applied either alone or blended with other synthetic, semi-synthetic, or natural polymers to achieve better mechanical and mucoadhesive properties and fast disintegration. In this review, we analyzed ODFs developed using natural polymers or blends involving natural polymers, such as maltodextrin, pullulan, starch, gelatin, collagen, alginate, chitosan, pectin, and others, to overview the recent publications and discuss how natural polymers can influence ODFs properties. more...
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- 2021
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9. Silk fibroin/chitosan/alginate multilayer membranes as a system for controlled drug release in wound healing
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Letícia de Almeida Paulo, Murilo Santos Pacheco, Gustavo Eiji Kano, Patricia Santos Lopes, and Mariana Agostini de Moraes
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Biocompatibility ,Alginates ,Silk ,Fibroin ,Biocompatible Materials ,02 engineering and technology ,engineering.material ,Biochemistry ,Chitosan ,03 medical and health sciences ,chemistry.chemical_compound ,Biopolymers ,Structural Biology ,Molecular Biology ,030304 developmental biology ,Wound Healing ,0303 health sciences ,Membranes ,Chemistry ,Biomaterial ,General Medicine ,Permeation ,021001 nanoscience & nanotechnology ,Bandages ,Drug Liberation ,Membrane ,Chemical engineering ,Delayed-Action Preparations ,Drug delivery ,engineering ,Biopolymer ,Fibroins ,0210 nano-technology - Abstract
In this study, we proposed the use of the biopolymers silk fibroin, chitosan and alginate, which are recognized for their biocompatibility and biodegradability, for the preparation of multilayer membranes aiming at high performance wound dressings with controlled drug delivery. The rationale was to combine in one material the mechanical properties of fibroin, the antimicrobial action of chitosan and the ideal exudate absorption of alginate, reaching a synergic effect of each biopolymer, without losing their individual intrinsic properties. The membranes were prepared by casting and diclofenac sodium was incorporated as model drug into the chitosan solution before the solvent evaporation, being retained in the middle layer of the membrane. Morphological, thermal, mechanical, solubility and barrier properties of the membranes were evaluated, as well as cytotoxicity and microbiological permeation. Results show that the incorporation of the drug did not affect mechanical and barrier properties, as well as microbiological permeation. Drug release was evaluated in vitro using simulated solution of wound exudate at 37 °C and diclofenac sodium was released from the multilayer membrane in 7 h, in which Fickian diffusion was the main mechanism associated. The results show the potential application of the biopolymer multilayer membranes as high-performance wound dressings. more...
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- 2020
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10. The Phase Equilibrium and Thermodynamic Modeling for Silk Fibroin and Sodium Alginate Blends with Different Proportion of Guluronic and Mannuronic Groups
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Laise Lopes, Mariana Agostini de Moraes, and Marisa Masumi Beppu
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- 2022
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11. Assessing the influence of silkworm cocoon’s age on the physicochemical properties of silk fibroin-based materials
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Marisa Masumi Beppu, Silvia Marisol Valles Ramirez, and Mariana Agostini de Moraes
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Materials science ,biology ,Polymer science ,Mechanical Engineering ,Fibroin ,02 engineering and technology ,010402 general chemistry ,021001 nanoscience & nanotechnology ,Condensed Matter Physics ,biology.organism_classification ,01 natural sciences ,0104 chemical sciences ,Mechanics of Materials ,Bombyx mori ,General Materials Science ,0210 nano-technology - Abstract
The novelty of this study was to investigate for the first time in literature the influence of Bombyx mori silkworm cocoon’s age on the properties of silk fibroin-based materials, during all stages of cocoon processing to obtain the fibroin film. The study started with the premise that the cocoon age could cause modifications on fibroin properties during processing and, consequently, a possible interference on the characteristics of the final product. Characterizations were performed using batches of cocoons produced in different years, named C0 (fresh cocoons) and C6 (six-year-old cocoons). The influence of cocoon’s aging was observed on dialyzed dispersion regarding the molecular weight, particle size, and conformation. C6 films showed a more crystalline structure and higher thermal resistance than C0 films. The findings reported in this work are relevant for the reproducibility of fibroin-based materials, and the cocoon age is a key factor that should be considered in the preparation of fibroin-based materials. more...
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- 2019
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12. Freezing influence on physical properties of glucomannan hydrogels
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Mariana Agostini de Moraes, Giovana Maria Genevro, and Marisa Masumi Beppu
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Materials science ,Modulus ,Glucomannan ,macromolecular substances ,02 engineering and technology ,complex mixtures ,Biochemistry ,Mannans ,03 medical and health sciences ,chemistry.chemical_compound ,Tissue engineering ,Structural Biology ,Freezing ,medicine ,Dehydration ,Molecular Biology ,Mechanical Phenomena ,030304 developmental biology ,chemistry.chemical_classification ,Slow freezing ,0303 health sciences ,Tissue Engineering ,Temperature ,technology, industry, and agriculture ,Hydrogels ,General Medicine ,Polymer ,Penetration (firestop) ,021001 nanoscience & nanotechnology ,medicine.disease ,Chemical engineering ,chemistry ,Self-healing hydrogels ,0210 nano-technology - Abstract
Freezing is an interesting technique to modify the mechanical properties and morphology of hydrogels. Konjac glucomannan (KGM) is a polysaccharide that has potential use in cutting-edge areas as biomaterials and tissue engineering. In this work, we deeply investigated the influence of freezing on KGM. For that, KGM hydrogels were frozen at several freezing rates and temperatures. Results show that the freezing rate was the most important factor in the final physical properties of the KGM hydrogels. Slow freezing rate produced structures with isotropic and large pores, while fast freezing resulted in hydrogels with small and aligned pores. In addition, hydrogels frozen at high temperature (−8 °C) exhibited higher penetration modulus than hydrogels frozen at low temperature (−28 °C), since dense polymer regions are formed due to higher molecules dehydration caused by slow freezing. KGM hydrogels that underwent freezing can be explored as scaffolds for tissue engineering, with improved structural and mechanical properties. more...
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- 2019
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13. Characterization and in vitro evaluation of chitosan/konjac glucomannan bilayer film as a wound dressing
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Letícia de Almeida Paulo, Marisa Masumi Beppu, Patricia Santos Lopes, Mariana Agostini de Moraes, Reginaldo Jose Gomes Neto, and Giovana Maria Genevro
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Thermogravimetric analysis ,Materials science ,Polymers and Plastics ,Biocompatibility ,Drug Evaluation, Preclinical ,02 engineering and technology ,engineering.material ,010402 general chemistry ,01 natural sciences ,Miscibility ,Mannans ,Differential scanning calorimetry ,X-Ray Diffraction ,Tensile Strength ,Candida albicans ,Escherichia coli ,Materials Chemistry ,Fourier transform infrared spectroscopy ,chemistry.chemical_classification ,Chitosan ,Bilayer ,Organic Chemistry ,Polymer ,Plants ,021001 nanoscience & nanotechnology ,Bandages ,0104 chemical sciences ,Chemical engineering ,chemistry ,Chromatography, Gel ,engineering ,Biopolymer ,0210 nano-technology - Abstract
A novel bilayer film of chitosan and konjac glucomannan were prepared by the two-step casting technique. Blend films were also prepared to investigate the interactions between the two polymers in the interfacial region of the bilayer structure. Scanning electron microscopy, Fourier transform infrared spectroscopy, and X-ray diffraction analysis showed that, unlike in the blends, the physicochemical properties of each biopolymer were preserved in the bilayer film. Differential scanning calorimetry and thermogravimetric analysis also indicated a good thermostability and miscibility for both polymers, probably due to strong hydrogen bonds between their polymer chains. Biological, mechanical and water vapor transmission tests showed a high biocompatibility, low cytotoxicity, and suitable mechanical and barrier properties of the bilayer films for wound dressing applications. more...
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- 2019
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14. Safety and structural integrity of N95/PFF2 respirators decontamination
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Juliana de Lima Lopes, F.A. Perrechil, Mônica Taminato, João Aléssio Juliano Perfeito, Wanderson Eduardo Coelho, Maria Cristina Gabrieloni, Maria Valdenice Lopes dos Santos, Mariana Agostini de Moraes, and Mavilde da Luz Gonçalves Pedreira more...
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business.product_category ,Coronavirus disease 2019 (COVID-19) ,Epidemiology ,Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ,Fit testing ,Major Article ,Equipment Reuse ,Medicine ,Humans ,Health Professional ,Respirator ,Decontamination ,Ventilators, Mechanical ,Health professionals ,Waste management ,business.industry ,SARS-CoV-2 ,Health Policy ,Prevention ,Public Health, Environmental and Occupational Health ,Structural integrity ,COVID-19 ,Human decontamination ,Work environment ,Coronavirus ,Infectious Diseases ,PPE ,business - Abstract
Background COVID-19 is caused by the SARS-CoV-2 virus, an emerging respiratory pathogen. The work environment represents a high-risk factor for health professionals. Given the scarcity of protective personal equipment due to global demand, decontamination and reuse studies should be carried out. Thus, the aim of this study was to evaluate the safety of a method of decontamination of N95/PFF2 respirators, especially regarding structural integrity. Methods N95/PFF2 respirators were subjected to hydrogen peroxide decontamination and analyzed using scanning electron microscopy and thermogravimetric analysis. Seven respirators of the same brand and lot were used, one being a control and the other six subjected to decontamination process. As for the sealing, a qualitative test was applied, in order to identify the changes in the structure that could damage the sealing of respirators. Results Indicated that the fiber morphology in all layers was not affected by the six decontamination cycles. Also, the thermal stability in the different layers was very similar. Fit testing showed that the respiradors submitted to all cycles of decontamination were approved. Conclusions Thus, it is possible to conclude that the hydrogen peroxide decontamination method is effective, since it does not alter the physical properties of the respirators. more...
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- 2021
15. Starch as a Matrix for Incorporation and Release of Bioactive Compounds: Fundamentals and Applications
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Lucas de Souza Falcão, Deborah Bento Coelho, Priscilla Carvalho Veggi, Pedro Henrique Campelo, Patrícia Melchionna Albuquerque, and Mariana Agostini de Moraes
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Polymers and Plastics ,General Chemistry - Abstract
Due to its abundance in nature and low cost, starch is one of the most relevant raw materials for replacing synthetic polymers in a number of applications. It is generally regarded as non-toxic, biocompatible, and biodegradable and, therefore, a safe option for biomedical, food, and packaging applications. In this review, we focused on studies that report the use of starch as a matrix for stabilization, incorporation, or release of bioactive compounds, and explore a wide range of applications of starch-based materials. One of the key application areas for bioactive compounds incorporated in starch matrices is the pharmaceutical industry, especially in orally disintegrating films. The packaging industry has also shown great interest in using starch films, especially those with antioxidant activity. Regarding food technology, starch can be used as a stabilizer in nanoemulsions, thus allowing the incorporation of bioactive compounds in a variety of food types. Starch also presents potential in the cosmetic industry as a delivery system. However, there are still several types of industry that could benefit from the incorporation of starch matrices with bioactive compounds, which are described in this review. In addition, the use of microbial bioactive compounds in starch matrices represents an almost unexplored field still to be investigated. more...
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- 2022
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16. Effect of chitosan and Aloe Vera extract concentrations on the physicochemical properties of chitosan biofilms
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Classius Ferreira da Silva, Patrícia Severino, Murilo Santos Pacheco, Cristiana Maria Pedroso Yoshida, Mariana Agostini de Moraes, Patricia Santos Lopes, Eliana B. Souto, and Universidade do Minho
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Polymers and Plastics ,wound healing ,02 engineering and technology ,010402 general chemistry ,01 natural sciences ,Fluid handling ,Aloe vera ,Article ,Chitosan ,lcsh:QD241-441 ,chemistry.chemical_compound ,lcsh:Organic chemistry ,chitosan membrane ,moisture vapor transmission rate ,color parameters ,Science & Technology ,biology ,Chemistry ,Biofilm ,General Chemistry ,021001 nanoscience & nanotechnology ,biology.organism_classification ,0104 chemical sciences ,3. Good health ,Chitosan membrane ,aloe vera ,tensile strength ,Wound dressing ,0210 nano-technology ,Nuclear chemistry ,Moisture vapor transmission rate - Abstract
Chitosan films have been extensively studied as dressings in formulations for the treatment of chronic wounds. The incorporation of aloe vera (Aloe barbadensis Miller) into chitosan dressings could potentialize the healing process since aloe vera shows several pharmacological activities. This work aimed to evaluate the effect of aloe vera and chitosan concentrations on the physicochemical properties of the developed films. The films were obtained by casting technique and characterized with respect to their color parameters, morphology, barrier and mechanical properties, and thermal analysis. Results showed that the presence of aloe vera modified the films color parameters, changed barrier properties, increased fluid handling capacity (FHC), and decreased water-vapor permeability (WVP). The reduced elongation at break resulted in more rigid films. Aloe vera concentration did not significantly change film properties, but the presence of this gel increased the films stability at temperatures below 200 °C, showing similar behavior as chitosan films above 400 °C. The results suggest a crosslinking/complexation between chitosan and aloe vera, which combine appropriate physicochemical properties for application as wound dressing materials., This work was supported by São Paulo Research Foundation (FAPESP) (2010/17.721-4), Portuguese Science and Technology Foundation (FCT) through the projects M-ERA-NET/0004/2015 (PAIRED) and UIDB/04469/2020 (strategic fund) funded by national funds, and co-financed Education (FCT/MEC) from national funds and FEDER, under the Partnership Agreement PT202, info:eu-repo/semantics/publishedVersion more...
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- 2021
17. Glucomannan asymmetric membranes for wound dressing
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Reginaldo Jose Gomes Neto, Letícia de Almeida Paulo, Mariana Agostini de Moraes, Giovana Maria Genevro, Marisa Beppu, and Patricia Santos Lopes
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Thermogravimetric analysis ,Materials science ,Biocompatibility ,Mechanical Engineering ,Swelling capacity ,Glucomannan ,02 engineering and technology ,010402 general chemistry ,021001 nanoscience & nanotechnology ,Condensed Matter Physics ,01 natural sciences ,0104 chemical sciences ,chemistry.chemical_compound ,Membrane ,Chemical engineering ,chemistry ,Mechanics of Materials ,Self-healing hydrogels ,General Materials Science ,Thermal stability ,0210 nano-technology ,Wound healing - Abstract
Asymmetric membranes present promising characteristics for wound dressing applications. A porous structure uptakes the wound exudate, whereas an occlusive layer (upper film) inhibits the microbial penetration and prevents an excessive loss of water. Konjac glucomannan (KGM) is a natural polysaccharide that has been investigated as wound dressings in the form of films, sponges, and hydrogels due to its flexibility, swelling capacity, biocompatibility, and low cost. However, there are no studies on literature regarding the development of KGM asymmetric membranes. In this study, we investigated a new casting—freezing process for the production of KGM asymmetric membranes. The scanning electron microscopy and thermogravimetric analyses indicated an asymmetric morphology and a good thermal stability of the membrane samples, respectively. Moreover, biological, mechanical, and fluid-handling capacity tests showed that the membrane is biocompatible and resistant to handling structure, which was also able to retain the ideal moist conditions for wound healing. more...
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- 2019
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18. Preface and acknowledgment
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Mariana Agostini de Moraes, Classius Ferreira da Silva, and Rodrigo Silveira Vieira
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- 2020
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19. List of contributors
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Mustapha Aazza, Khalina Binti Abdan, Hammou Ahlafi, Augustine Amalraj, Md. Anwaruzzaman, Lirian Ferreira Rosa Pereira Bom, Eric Chan Wei Chiang, Carolina Gregório Costa, Rejiane da Rosa Schio, Classius Ferreira da Silva, Mariana Agostini de Moraes, Guilherme Luiz Dotto, Sreerag Gopi, Sreeraj Gopi, Md. Lawshan Habib, Lee Ching Hao, M. Mehedi Hasan, Tan Choon Hui, E. Jackcina Stobel Christy, K. Jayaraj, Shintu Jude, Jun-ichi Kadokawa, Md. Kamruzzaman, M. Nuruzzaman Khan, Evandro Stoffels Mallmann, Cristiane Reis Martins, Jafar M. Milani, Hamou Moussout, Anitha Pius, Mohammed Mizanur Rahman, A. Rajeswari, Samar Sahraee, Rosnita A. Talib, and Soon Chu Yong more...
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- 2020
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20. Contributors
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Vera Alejandra Alvarez, Mariana Altenhofen da Silva, Ioannis Anastopoulos, Rogério Aparecido Bataglioli, Marisa Masumi Beppu, Andrea Cristiane Krause Bierhalz, Fernanda Carla Bombaldi de Souza, Renata Francielle Bombaldi de Souza, Adrián Bonilla-Petriciolet, Josiane Gonçalves Borges, Tito Roberto Sant’Anna Cadaval, Bruna Gregatti de Carvalho, Rosemary Aparecida de Carvalho, Tecia Vieira Carvalho, Pascale Chevallier, Viktor Oswaldo Cárdenas Concha, Luana Roland Ferreira Contini, Rodrigo Cué-Sampedro, João Dias-Ferreira, Guilherme Luiz Dotto, Meryem Sedef Erdal, Júlia Vaz Ernesto, Ana R. Fernandes, Emanuel M. Fernandes, Eduardo de Paulo Ferreira, Classius Ferreira da Silva, Ronaldo Ferreira do Nascimento, Leonardo Fernandes Fraceto, Vitor Augusto dos Santos Garcia, Lucimara Gaziola de la Torre, Sandy Danielle Lucindo Gomes, Sevgi Güngör, Saartje Hernalsteens, Carmen Guadalupe Hernández-Valencia, Ahmad Hosseini-Bandegharaei, Mohd Ikmar Nizam Mohamad Isa, Emine Kahraman, Theo Guenter Kieckbusch, Henryk Koroniak, Ramón Díaz de León, Éder Cláudio Lima, Patricia Santos Lopes, Vinícius Borges Vieira Maciel, Diego Mantovani, Gustavo Martínez-Castellanos, Agnes Batista Meireles, Enayde de Almeida Melo, Ângela Maria Moraes, Mariana Agostini de Moraes, Anaftália Felismino Morais, Nur Hafiza Mr Muhamaruesa, Roberto Nasser, Beatriz C. Naveros, Deise Ochi, Romina Paola Ollier, Yıldız Özsoy, Neith Pacheco, Anderson Espirito Santo Pereira, Laura Oliveira Péres, Ana Luiza Resende Pires, Rui L. Reis, Ansorena María Roberta, João Batista Maia Rocha Neto, Luísa C. Rodrigues, Laura Mabel Sanchez, J.A. Sánchez-Fernández, Andrelina Maria Pinheiro Santos, Gilberto Dantas Saraiva, Patricia Severino, Keiko Shirai, Simone S. Silva, Mariangela de Fátima Silva, Jackson Wesley Silva dos Santos, Vicente de Oliveira Sousa Neto, João Vinícios Wirbitzki da Silveira, José L. Soriano, Eliana B. Souto, Clayton Campelo de Souza, Thiago Bezerra Taketa, Bruno Thorihara Tomoda, Fernanda Maria Vanin, Anna Cecilia Venturini, Rodrigo Silveira Vieira, Justyna Walkowiak-Kulikowska, Joanna Wolska, Patrícia Hissae Yassue-Cordeiro, and Cristiana Maria Pedroso Yoshida more...
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- 2020
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21. Characterization of biopolymer membranes and films: Physicochemical, mechanical, barrier, and biological properties
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Julia V. Ernesto, Bruno Thorihara Tomoda, Patricia Santos Lopes, Laura Oliveira Péres, Mariana Agostini de Moraes, Patrícia Hissae Yassue-Cordeiro, and Classius Ferreira da Silva
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Materials science ,engineering.material ,Characterization (materials science) ,Contact angle ,symbols.namesake ,Membrane ,X-ray photoelectron spectroscopy ,Chemical engineering ,engineering ,symbols ,Biopolymer ,Fourier transform infrared spectroscopy ,Thermal analysis ,Raman spectroscopy - Abstract
In this chapter, a full overview of the main characterization techniques of biopolymer membranes and films is presented, focusing on the fundamentals and methods of analysis of each technique applied to biopolymers. First, a complete publications search on the main characterizations of biopolymer films and membranes is reported, specifying the number of published papers per technique from 1999 to 2018. Then, the characterizations are sorted by type. In the physicochemical characterization section, microscopy techniques, Fourier transform infrared spectroscopy, Raman spectroscopy, nuclear magnetic resonance spectroscopy, X-ray diffraction, X-ray photoelectron spectroscopy, and thermal analysis are addressed. Then, physical characterizations, such as swelling, degradation/erosion degree, mechanical and barrier properties, contact angle, and textural analysis applied to biopolymer membranes and films are elucidated. Finally, the main biological characterizations are reported, such as cytotoxicity, sensitization capacity, and irritation potential. more...
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- 2020
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22. (Bio)composites of chitin/chitosan with natural fibers
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Classius Ferreira da Silva, Lirian Ferreira Rosa Pereira Bom, Carolina Gregório Costa, Cristiane Reis Martins, and Mariana Agostini de Moraes
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Chitosan ,chemistry.chemical_compound ,Materials science ,chemistry ,Chitin ,Natural materials ,Filler (materials) ,engineering ,Biopolymer ,Composite material ,Raw material ,Biodegradation ,engineering.material - Abstract
Chitosan is a semisynthetic biopolymer made from chitin which is the second most abundant biopolymer on Earth. In addition to being abundant, chitosan exhibits properties such as biodegradability and nontoxicity that make it very attractive for applications in diverse fields. However, the mechanical properties of chitosan devices represent one of the challenges in the use of chitosan in many areas such as medical, packaging, and the environment. The production of chitosan composites (or biocomposites) may represent a strategy to overcome problems related to mechanical properties, for example, without losing properties like their positive charges. Nevertheless, in the case of a biodegradable matrix such as chitosan, the use of some synthetic fillers may alter the features mentioned above due to the nonbiodegradability of the filler. In this sense, the use of natural fillers to obtain biocomposites of chitosan has grown in recent years, mainly due to the appeal of the two natural materials (chitosan and filler). In this chapter, we focus on (bio)composites of chitin and chitosan only with natural fillers that have fibrous morphology, focusing on different raw materials and applications. First, we show an introduction to the increase in publications in the field; then, we discuss natural fibers, their properties and treatments. Finally, we review in depth the publications about (bio)composites with chitin/chitosan, which were classified by raw material. more...
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- 2020
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23. Biopolymer Membranes and Films : Health, Food, Environment, and Energy Applications
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Mariana Agostini De Moraes, Classius Ferreira Da Silva, Rodrigo Silveria Vieira, Mariana Agostini De Moraes, Classius Ferreira Da Silva, and Rodrigo Silveria Vieira
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- Polymeric membranes, Biopolymers
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Biopolymer Membranes and Films: Health, Food, Environment, and Energy Applications presents the latest techniques for the design and preparation of biopolymer-based membranes and films, leading to a range of cutting-edge applications. The first part of the book introduces the fundamentals of biopolymers, two-dimensional systems, and the characterization of biopolymer membranes and films, considering physicochemical, mechanical and barrier properties. Subsequent sections are organized by application area, with each chapter explaining how biopolymer-based membranes or films can be developed for specific innovative uses across the health, food, environmental and energy sectors. This book is a valuable resource for researchers, scientists and advanced students involved in biopolymer science, polymer membranes and films, polymer chemistry and materials science, as well as for those in industry and academia who are looking to develop materials for advanced applications in the health, food science, environment or energy industries. - Presents detailed coverage of a range of novel applications in key strategic areas across health, food, environment and energy - Considers the difficulties associated with two-dimensional materials - Assists the reader in selecting the best materials and properties for specific applications - Helps researchers, scientists and engineers combine the enhanced properties of membranes and films with the sustainable characteristics of biopolymer-based materials more...
- Published
- 2020
24. Assessing the Influence of Dyes Physico-Chemical Properties on Incorporation and Release Kinetics in Silk Fibroin Matrices
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F.A. Perrechil, Mariana Agostini de Moraes, Murilo Santos Pacheco, Yasmin Broso Abranches, Juliane Viganó, and Bruno Thorihara Tomoda
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microparticles ,Molar mass ,Polymers and Plastics ,Chemistry ,Kinetics ,dye release ,Cationic polymerization ,Fibroin ,General Chemistry ,engineering.material ,Article ,lcsh:QD241-441 ,Hydrophobic effect ,lcsh:Organic chemistry ,Chemical engineering ,biopolymer ,Prolonged release ,Self-healing hydrogels ,engineering ,Biopolymer ,hydrogel - Abstract
Silk fibroin (SF) is a promising and versatile biodegradable protein for biomedical applications. This study aimed to develop a prolonged release device by incorporating SF microparticles containing dyes into SF hydrogels. The influence of dyes on incorporation and release kinetics in SF based devices were evaluated regarding their hydrophilicity, molar mass, and cationic/anionic character. Hydrophobic and cationic dyes presented high encapsulation efficiency, probably related to electrostatic and hydrophobic interactions with SF. The addition of SF microparticles in SF hydrogels was an effective method to prolong the release, increasing the release time by 10-fold. more...
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- 2021
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25. EFICÁCIA E SEGURANÇA DE MÉTODO DE DESCONTAMINAÇÃO DE MÁSCARAS N95/PFF2
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Maria Cristina Gabrielloni, Mariana Agostini de Moraes, Maria Angélica Sorgini Peterlini, Wanderson Eduardo Coelho, Mônica Taminato, João Aléssio Juliano Perfeito, Mavilde da Luz Gonçalves Pedreira, Maria Valdenice Lopes dos Santos, and Fabianna Bonsonato more...
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Microbiology (medical) ,Infectious Diseases ,Political science ,lcsh:QR1-502 ,lcsh:RC109-216 ,Humanities ,lcsh:Microbiology ,Or‐19 ,lcsh:Infectious and parasitic diseases - Published
- 2021
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26. Evaluation of diclofenac sodium incorporation in alginate membranes as potential drug release system
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Murilo Santos Pacheco, Mariana Agostini de Moraes, Thaís Belarmino da Silva, and Bruno Thorihara Tomoda
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010302 applied physics ,Materials science ,Kinetics ,02 engineering and technology ,Diclofenac Sodium ,engineering.material ,021001 nanoscience & nanotechnology ,01 natural sciences ,chemistry.chemical_compound ,Membrane ,chemistry ,Chemical engineering ,0103 physical sciences ,Ultimate tensile strength ,Drug delivery ,engineering ,Glycerol ,medicine ,General Materials Science ,Biopolymer ,Swelling ,medicine.symptom ,0210 nano-technology - Abstract
In this study, we proposed the use of the biopolymer alginate to produce membranes with diclofenac sodium incorporated as model-drug aiming at wound dressing application with drug delivery. The membranes were prepared by casting and the drug was incorporated directly into alginate solution, being retained within the membrane. Morphological, chemical, mechanical and barrier properties were evaluated, as well as the release kinetics in vitro using simulated exudate fluid at 37 °C. Results show that the membranes are malleable in the glycerol presence and more resistant to water after crosslinking. The incorporation of diclofenac sodium did not affect barrier properties, but influenced the mechanical properties, increasing the total thickness (from 0.108 to 0.209 mm) and reducing tensile strength (from 40.85 to 21.76 MPa). Drug release evaluation shows that anomalous transport is the major rate-controlling mechanism, where the swelling or erosion of the alginate matrix is the major responsible for the diclofenac sodium release, with a small contribution of Fickian diffusion mechanism. The results show the potential of application of the alginate membranes for wound dressings with drug delivery for enhancing healing process. more...
- Published
- 2020
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27. Study of phase separation in blends of silk fibroin and sodium alginate in solution and in solid state
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Laise Maia Lopes, Marisa Masumi Beppu, and Mariana Agostini de Moraes
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Materials science ,Polymers and Plastics ,Scanning electron microscope ,Spinodal decomposition ,Organic Chemistry ,Infrared spectroscopy ,Fibroin ,02 engineering and technology ,010402 general chemistry ,021001 nanoscience & nanotechnology ,01 natural sciences ,Light scattering ,0104 chemical sciences ,Matrix (chemical analysis) ,Membrane ,Chemical engineering ,Attenuated total reflection ,Materials Chemistry ,0210 nano-technology - Abstract
Silk fibroin (SF) and sodium alginate (SA) are natural polymers with many applications as biomaterials. It is possible to make blends with them in order to improve their properties. Those blends are partially miscible; therefore, understanding the mechanism and phase equilibrium of this system is important to better understand the interaction between these natural polymers. This work analyzed the mechanism of phase separation of SF and SA blends with different composition in solution and in the solid state (as membranes) using small angle light scattering with a He-Ne laser. Polymer interaction and conformation were investigated by Fourier-Transform Infrared Spectroscopy with Attenuated Total Reflectance (FTIR-ATR) and X-Ray Diffraction (XRD), and membrane morphology was analyzed by Scanning Electron Microscopy (SEM). SEM images showed interpenetrated globules in the matrix. Light scattering profile for blends in solution and in the solid state showed a peak of intensity suggesting that phase separation occurs by spinodal decomposition. more...
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- 2018
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28. Chitosan-based nanocomposites for drug delivery
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Cristiana Maria Pedroso Yoshida, Eliana B. Souto, Eliezer Ladeia Gomes, Mariana Agostini de Moraes, Patrícia Severino, Classius Ferreira da Silva, and Patricia Hissae Yassue-Cordeiro
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Nanocomposite ,Materials science ,Biocompatibility ,Nanoparticle ,Nanotechnology ,02 engineering and technology ,engineering.material ,Biodegradation ,010402 general chemistry ,021001 nanoscience & nanotechnology ,01 natural sciences ,0104 chemical sciences ,Chitosan ,chemistry.chemical_compound ,Chitin ,chemistry ,Drug delivery ,engineering ,Biopolymer ,0210 nano-technology - Abstract
Chitosan (CS) is a semi-synthetic biopolymer obtained from chitin that is the second most abundant biopolymer. Many devices produced from CS have been widely used for drug delivery systems and biomaterials. Biocompatibility, biodegradability, nonallergenicity, and antimicrobial activity are advantageous properties of CS; moreover, CS has also exhibited healing properties. Some properties can be potentiated by using the CS to produce CS-based nanocomposites. In this sense, this chapter intends to give some CS nanodevices with different kind of fillers (reinforcements) and their application to the drug delivery systems. Fillers such as nanoparticles, nanolayer, and nanofibrous are discussed. more...
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- 2018
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29. Silk fibroin membranes with self‐assembled globular structures for controlled drug release
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Marisa Masumi Beppu, Fulvio G. Corazza, Bruno Thorihara Tomoda, Patricia Santos Lopes, and Mariana Agostini de Moraes
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Membrane ,Polymers and Plastics ,Chemistry ,Materials Chemistry ,Drug release ,Biophysics ,Fibroin ,General Chemistry ,Surfaces, Coatings and Films ,Self assembled - Published
- 2019
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30. Glucomannan asymmetric membranes for wound dressing–Erratum
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Mariana Agostini de Moraes, Reginaldo Jose Gomes Neto, Patricia Santos Lopes, Giovana Maria Genevro, Letícia de Almeida Paulo, and Marisa Masumi Beppu
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010302 applied physics ,Materials science ,Polymer science ,Funding grant ,Mechanical Engineering ,Glucomannan ,02 engineering and technology ,021001 nanoscience & nanotechnology ,Condensed Matter Physics ,Asymmetric membranes ,01 natural sciences ,chemistry.chemical_compound ,chemistry ,Mechanics of Materials ,Wound dressing ,0103 physical sciences ,General Materials Science ,0210 nano-technology - Abstract
After publication of the paper, the authors realized that the affiliation of the fourth author (Tiberiu Esanu) was given incorrectly. Its correct version appears above. Moreover, a second funding grant was missed in the acknowledgements. We give their complete correct version below. more...
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- 2019
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31. Production and characterization of fibroin hydrogel using waste silk fibers
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Attilio Converti, Antonio Carlos Bloise Junior, Natalia Marchesan Bexiga, Mariana Agostini de Moraes, Bronislaw Polakiewicz, and Marisa Masumi Beppu
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Thermogravimetric analysis ,Materials science ,Polymers and Plastics ,Physicochemical properties ,General Chemical Engineering ,Fibroin ,02 engineering and technology ,010402 general chemistry ,01 natural sciences ,Biomaterials ,Crystallinity ,Biopolymers and renewable polymers ,Chemical Engineering (all) ,Composite material ,Spinning ,Processing conditions ,Chemistry (all) ,General Chemistry ,021001 nanoscience & nanotechnology ,Environmentally friendly ,Random coil ,0104 chemical sciences ,SILK ,Chemical engineering ,POLÍMEROS (QUÍMICA ORGÂNICA) ,Gels ,Self-healing hydrogels ,0210 nano-technology - Abstract
The use of natural resources, especially processing wastes, as low cost and environmentally friendly alternative aiming high value-added applications is a subject of broad interest. Since the Brazilian silk production annually generates a large amount of waste during the silk fibers processing, this work explores the preparation and characterization of silk fibroin hydrogels using spinning waste silk fibers from textile processing and the processed ones. Hydrogels were obtained directly by dialyzing silk fibroin solutions against frequent changes of water until the gelation point and then lyophilized and characterized in terms of their morphology, crystallinity, thermal resistance and secondary structure. X-ray diffraction analysis revealed the presence of β-sheet conformation related to sol-gel transition. FT-IR spectra indicated the coexistence of random coil (silk I) and β-sheet (silk II) structures, with predominance of β-sheet conformation for hydrogels from processed silk fibers. From thermogravimetric analysis the presence of β-sheet secondary conformation was demonstrated by a degradation peak around 292 °C for both hydrogels. Freeze-dried hydrogels presented sheet or leaf like morphology and no significant change was observed among the hydrogels from waste silk fibers and processed ones. These characteristics suggest that silk fibroin hydrogels prepared from spinning waste silk fibers and obtained directly by dialysis can be potential candidates for biomaterials application, such as drug delivery systems and for wound dressings. more...
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- 2017
32. PREPARO DE MATRIZES OBTIDAS A PARTIR DE POLÍMEROS NATURAIS PARA LIBERAÇÃO CONTROLADA DE FÁRMACOS
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Mariana Agostini de Moraes, Bruno Thorihara Tomoda, and Marisa Beppu
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- 2016
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33. Preparo de membrana densa de fibroína de seda para liberação controlada de fármacos
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Bruno Thorihara Tomoda and Mariana Agostini de Moraes
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- 2015
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34. Phase Behaviour and Miscibility Studies of Collagen/Silk Fibroin Macromolecular System in Dilute Solutions and Solid State
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Alina Sionkowska, Katarzyna Lewandowska, Maria Pia Ferraz, Ima Ghaeli, Marisa Masumi Beppu, Mariana Agostini de Moraes, Frederico Ferreira-da-Silva, Fernando J. Monteiro, and Instituto de Investigação e Inovação em Saúde more...
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Materials science ,Silk ,Silk fibroin ,Pharmaceutical Science ,Fibroin ,Biocompatible Materials ,biopolymers ,02 engineering and technology ,010402 general chemistry ,01 natural sciences ,Miscibility ,Article ,Analytical Chemistry ,protein-protein interaction ,lcsh:QD241-441 ,Contact angle ,Biopolymers ,Protein-protein interaction ,Differential scanning calorimetry ,lcsh:Organic chemistry ,Phase (matter) ,Spectroscopy, Fourier Transform Infrared ,Drug Discovery ,Polymer chemistry ,Animals ,Physical and Theoretical Chemistry ,Fourier transform infrared spectroscopy ,Coacervate ,fungi ,Organic Chemistry ,technology, industry, and agriculture ,Coacervation ,Bombyx ,021001 nanoscience & nanotechnology ,Random coil ,0104 chemical sciences ,Chemical engineering ,silk fibroin ,Chemistry (miscellaneous) ,miscibility ,Microscopy, Electron, Scanning ,coacervation ,Molecular Medicine ,Collagen ,Fibroins ,0210 nano-technology - Abstract
Miscibility is an important issue in biopolymer blends for analysis of the behavior of polymer pairs through the detection of phase separation and improvement of the mechanical and physical properties of the blend. This study presents the formulation of a stable and one-phase mixture of collagen and regenerated silk fibroin (RSF), with the highest miscibility ratio between these two macromolecules, through inducing electrostatic interactions, using salt ions. For this aim, a ternary phase diagram was experimentally built for the mixtures, based on observations of phase behavior of blend solutions with various ratios. The miscibility behavior of the blend solutions in the miscible zones of the phase diagram was confirmed quantitatively by viscosimetric measurements. Assessing the effects of biopolymer mixing ratio and salt ions, before and after dialysis of blend solutions, revealed the importance of ion-specific interactions in the formation of coacervate-based materials containing collagen and RSF blends that can be used in pharmaceutical, drug delivery, and biomedical applications. Moreover, the conformational change of silk fibroin from random coil to beta sheet, in solution and in the final solid films, was detected by circular dichroism (CD) and Fourier transform infrared spectroscopy (FTIR), respectively. Scanning electron microscopy (SEM) exhibited alterations of surface morphology for the biocomposite films with different ratios. Surface contact angle measurement illustrated different hydrophobic properties for the blended film surfaces. Differential scanning calorimetry (DSC) showed that the formation of the beta sheet structure of silk fibroin enhances the thermal stability of the final blend films. Therefore, the novel method presented in this study resulted in the formation of biocomposite films whose physico-chemical properties can be tuned by silk fibroin conformational changes by applying different component mixing ratios. more...
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- 2017
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35. Silk fibroin membranes for controlled release of drugs: incorporation method, chemical and morphological characteristics
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Bruno, Tomoda, primary, Marisa, Beppu, additional, Mariana, Agostini De Moraes, additional, and Giovana, Genevro, additional
- Published
- 2016
- Full Text
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36. Detention of chitosan of crab shell of Charybdis hellerii in movies polymeric obtained from use with radiation ionizing
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Maiara Salla Ferreira, Aurea Beatriz Cerqueira Geraldo, Marina Ferreira Lima, and Mariana Agostini de Moraes
- Abstract
A quitosana é um polisacarídeo obtido pela desacetilação das moléculas de quitina, principal constituinte de alguns fungos e do exoesqueleto de crustáceos e insetos. Os grupos amino presentes na quitosana conferem-lhe importantes propriedades biológicas, como a biodegradação, biocompatibilidade, atividade/efeitos imunológicos e atividade antibacteriana. A desacetilação da quitina é um processo cuja conversão é agressiva, já que exige o ataque da quitina em solução de álcalis em alta concentração e à quente, com duração de 6 a 8 horas. Neste trabalho, carapaças de siri da espécie Charybdis hellerii foi fragmentada e pré-tratada para a obtenção da quitosana e cada etapa, desde o pré-tratamento do material in natura à sua conversão em quitosana, foi investigada detalhadamente. Observou-se que dose e taxa de dose não influenciaram no pré-tratamento ou na etapa de desacetilação da quitina; na dose de 20 kGy (gama ou feixe de elétrons), o processo de conversão teve duração de 60 minutos. A quitosana obtida teve baixa massa molar e grau de desacetilação comparável á quitosana padrão (SA), dependendo das condições de irradiação. Além disso, apresentou inibição da atividade bacteriana tanto livre como imobilizada em substratos poliméricos de polipropileno e de polietileno processados também por radiação ionizante. Chitosan is a polysaccharide obtained from chitins molecule deacetylation, which is the main composition of certain fungi species and crustaceans and insects exoskeleton. The amino groups present in chitosan give it important biological properties such as biodegradability and biocompatibility, activity/immunological effects and antibacterial healing. The deacetylation of chitin is an aggressive process, which reaction processes in 6 to 8 hours under hot concentrated alkali solution. In this work, Charybdis hellerii crab shells was fragmented and pre-treated for chitosan obtention and each conversion step, from in natura material pre-treatment to final chitosan, were investigated in deteails. It was observed dose and dose rate have not influence neither pre-treatment nor chitin deacetylation steps; at 20 kGy (from gamma or electron beam sources), the conversion process was performed in 60 minutes. The obtained chitosan presented low weight and deacetylation degree compared to standard chitosan, considering specific irradiation conditions. Also, obtained chitosan presented bacterial inactivity as a free compoud as immobilized onto polymeric substrates such polypropylene and polyethylene, also processed by ionizing radiation. more...
- Published
- 2016
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