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195 results on '"Obeng, Esther A."'

1. Proteasome inhibition targets the KMT2A transcriptional complex in acute lymphoblastic leukemia

Author

Kamens, Jennifer L., Nance, Stephanie, Koss, Cary, Xu, Beisi, Cotton, Anitria, Lam, Jeannie W., Garfinkle, Elizabeth A. R., Nallagatla, Pratima, Smith, Amelia M. R., Mitchell, Sharnise, Ma, Jing, Currier, Duane, Wright, William C., Kavdia, Kanisha, Pagala, Vishwajeeth R., Kim, Wonil, Wallace, LaShanale M., Cho, Ji-Hoon, Fan, Yiping, Seth, Aman, Twarog, Nathaniel, Choi, John K., Obeng, Esther A., Hatley, Mark E., Metzger, Monika L., Inaba, Hiroto, Jeha, Sima, Rubnitz, Jeffrey E., Peng, Junmin, Chen, Taosheng, Shelat, Anang A., Guy, R. Kiplin, and Gruber, Tanja A.

Published
2023
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2. Author Correction: Proteasome inhibition targets the KMT2A transcriptional complex in acute lymphoblastic leukemia

Author

Kamens, Jennifer L., Nance, Stephanie, Koss, Cary, Xu, Beisi, Cotton, Anitria, Lam, Jeannie W., Garfinkle, Elizabeth A. R., Nallagatla, Pratima, Smith, Amelia M. R., Mitchell, Sharnise, Ma, Jing, Currier, Duane, Wright, William C., Kavdia, Kanisha, Pagala, Vishwajeeth R., Kim, Wonil, Wallace, LaShanale M., Cho, Ji-Hoon, Fan, Yiping, Seth, Aman, Twarog, Nathaniel, Choi, John K., Obeng, Esther A., Hatley, Mark E., Metzger, Monika L., Inaba, Hiroto, Jeha, Sima, Rubnitz, Jeffrey E., Peng, Junmin, Chen, Taosheng, Shelat, Anang A., Guy, R. Kiplin, and Gruber, Tanja A.

Published
2023
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4. An inflammatory state remodels the immune microenvironment and improves risk stratification in acute myeloid leukemia

Author

Lasry, Audrey, Nadorp, Bettina, Fornerod, Maarten, Nicolet, Deedra, Wu, Huiyun, Walker, Christopher J., Sun, Zhengxi, Witkowski, Matthew T., Tikhonova, Anastasia N., Guillamot-Ruano, Maria, Cayanan, Geraldine, Yeaton, Anna, Robbins, Gabriel, Obeng, Esther A., Tsirigos, Aristotelis, Stone, Richard M., Byrd, John C., Pounds, Stanley, Carroll, William L., Gruber, Tanja A., Eisfeld, Ann-Kathrin, and Aifantis, Iannis

Published
2023
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6. SF3B1 mutation and ATM deletion codrive leukemogenesis via centromeric R-loop dysregulation

Author

Cusan, Martina, Shen, Haifeng, Zhang, Bo, Liao, Aijun, Yang, Lu, Jin, Meiling, Fernandez, Mike, Iyer, Prajish, Wu, Yiming, Hart, Kevyn, Gutierrez, Catherine, Nik, Sara, Pruett-Miller, Shondra M., Stark, Jeremy, Obeng, Esther A., Bowman, Teresa V., Wu, Catherine J., Lin, Ren-Jang, and Wang, Lili

Subjects
Thermo Fisher Scientific Inc., Genes -- Genetic aspects, B cells -- Genetic aspects, RNA -- Genetic aspects, Health care industry
Abstract

RNA splicing factor SF3B1 is recurrently mutated in various cancers, particularly in hematologic malignancies. We previously reported that coexpression of Sf3b1 mutation and Atm deletion in B cells, but not either lesion alone, leads to the onset of chronic lymphocytic leukemia (CLL) with CLL cells harboring chromosome amplification. However, the exact role of Sf3b1 mutation and Atm deletion in chromosomal instability (CIN) remains unclear. Here, we demonstrated that SF3B1 mutation promotes centromeric R-loop (cen-R-loop) accumulation, leading to increased chromosome oscillation, impaired chromosome segregation, altered spindle architecture, and aneuploidy, which could be alleviated by removal of cen-R- loop and exaggerated by deletion of ATM. Aberrant splicing of key genes involved in R-loop processing underlay augmentation of cen-R-loop, as overexpression of the normal isoform, but not the altered form, mitigated mitotic stress in SF3B1-mutant cells. Our study identifies a critical role of splice variants in linking RNA splicing dysregulation and CIN and highlights cen-R-loop augmentation as a key mechanism for leukemogenesis., Introduction Cancer genome sequencing has identified high-frequency mutations of splicing factor SF3B1 in hematologic malignancies such as myelodysplastic syndrome and chronic lymphocytic leukemia (CLL) (1-3). As one of the most [...]

Published
2023
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7. Engineering naturally occurring CD7− T cells for the immunotherapy of hematological malignancies

Author

Freiwan, Abdullah, Zoine, Jaquelyn T., Crawford, Jeremy Chase, Vaidya, Abishek, Schattgen, Stefan A., Myers, Jacquelyn A., Patil, Sagar L., Khanlari, Mahsa, Inaba, Hiroto, Klco, Jeffery M., Mullighan, Charles G., Krenciute, Giedre, Chockley, Peter J., Naik, Swati, Langfitt, Deanna M., Mamonkin, Maksim, Obeng, Esther A., Thomas, Paul G., Gottschalk, Stephen, and Velasquez, M. Paulina

Published
2022
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9. Preferential expansion of CD8+ CD19-CAR T cells postinfusion and the role of disease burden on outcome in pediatric B-ALL

Author

Talleur, Aimee C., Qudeimat, Amr, Métais, Jean-Yves, Langfitt, Deanna, Mamcarz, Ewelina, Crawford, Jeremy Chase, Huang, Sujuan, Cheng, Cheng, Hurley, Caitlin, Madden, Renee, Sharma, Akshay, Suliman, Ali, Srinivasan, Ashok, Velasquez, M. Paulina, Obeng, Esther A., Willis, Catherine, Akel, Salem, Karol, Seth E., Inaba, Hiroto, Bragg, Allison, Zheng, Wenting, Zhou, Sheng M., Schell, Sarah, Tuggle-Brown, MaCal, Cullins, David, Patil, Sagar L, Li, Ying, Thomas, Paul G., Zebley, Caitlin, Youngblood, Benjamin, Pui, Ching-Hon, Lockey, Timothy, Geiger, Terrence L., Meagher, Michael M., Triplett, Brandon M., and Gottschalk, Stephen

Published
2022
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10. A Murine Model of Chronic Lymphocytic Leukemia Based on B Cell-Restricted Expression of Sf3b1 Mutation and Atm Deletion

Author

Yin, Shanye, Gambe, Rutendo G, Sun, Jing, Martinez, Aina Zurita, Cartun, Zachary J, Regis, Fara Faye D, Wan, Youzhong, Fan, Jean, Brooks, Angela N, Herman, Sarah EM, Hacken, Elisa ten, Taylor-Weiner, Amaro, Rassenti, Laura Z, Ghia, Emanuela M, Kipps, Thomas J, Obeng, Esther A, Cibulskis, Carrie L, Neuberg, Donna, Campagna, Dean R, Fleming, Mark D, Ebert, Benjamin L, Wiestner, Adrian, Leshchiner, Ignaty, DeCaprio, James A, Getz, Gad, Reed, Robin, Carrasco, Ruben D, Wu, Catherine J, and Wang, Lili

Subjects
Rare Diseases, Lymphoma, Cancer, Genetics, Hematology, 2.1 Biological and endogenous factors, Aetiology, Adenine, Agammaglobulinaemia Tyrosine Kinase, Alternative Splicing, Animals, Antineoplastic Agents, Ataxia Telangiectasia Mutated Proteins, B-Lymphocytes, Cellular Senescence, DNA Damage, Gene Deletion, Genetic Predisposition to Disease, Genomic Instability, Humans, Leukemia, Lymphocytic, Chronic, B-Cell, Mice, 129 Strain, Mice, Inbred C57BL, Mice, Knockout, Mice, Mutant Strains, Mutation, Neoplasms, Experimental, Phenotype, Phosphoproteins, Piperidines, Protein Kinase Inhibitors, Pyrazoles, Pyrimidines, RNA Splicing Factors, Receptors, Antigen, B-Cell, Signal Transduction, Tumor Cells, Cultured, ATM, BCR signaling, CLL, SF3B1, murine model, Neurosciences, Oncology and Carcinogenesis, Oncology & Carcinogenesis
Abstract

SF3B1 is recurrently mutated in chronic lymphocytic leukemia (CLL), but its role in the pathogenesis of CLL remains elusive. Here, we show that conditional expression of Sf3b1-K700E mutation in mouse B cells disrupts pre-mRNA splicing, alters cell development, and induces a state of cellular senescence. Combination with Atm deletion leads to the overcoming of cellular senescence and the development of CLL-like disease in elderly mice. These CLL-like cells show genome instability and dysregulation of multiple CLL-associated cellular processes, including deregulated B cell receptor signaling, which we also identified in human CLL cases. Notably, human CLLs harboring SF3B1 mutations exhibit altered response to BTK inhibition. Our murine model of CLL thus provides insights into human CLL disease mechanisms and treatment.

Published
2019

12. Author Correction: An inflammatory state remodels the immune microenvironment and improves risk stratification in acute myeloid leukemia

Author

Lasry, Audrey, Nadorp, Bettina, Fornerod, Maarten, Nicolet, Deedra, Wu, Huiyun, Walker, Christopher J., Sun, Zhengxi, Witkowski, Matthew T., Tikhonova, Anastasia N., Guillamot-Ruano, Maria, Cayanan, Geraldine, Yeaton, Anna, Robbins, Gabriel, Obeng, Esther A., Tsirigos, Aristotelis, Stone, Richard M., Byrd, John C., Pounds, Stanley, Carroll, William L., Gruber, Tanja A., Eisfeld, Ann-Kathrin, and Aifantis, Iannis

Published
2023
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13. Memory T-cell enriched haploidentical transplantation with NK cell addback results in promising long-term outcomes: a phase II trial.

Author

Naik, Swati, Li, Ying, Talleur, Aimee C., Selukar, Subodh, Ashcraft, Emily, Cheng, Cheng, Madden, Renee M., Mamcarz, Ewelina, Qudeimat, Amr, Sharma, Akshay, Srinivasan, Ashok, Suliman, Ali Y., Epperly, Rebecca, Obeng, Esther A., Velasquez, M. Paulina, Langfitt, Deanna, Schell, Sarah, Métais, Jean-Yves, Arnold, Paula Y., and Hijano, Diego R.

Subjects
IMMUNOLOGIC memory, KILLER cells, CELL transplantation, CHILD patients, HEMATOLOGIC malignancies
Abstract

Background: Relapse remains a challenge after transplantation in pediatric patients with hematological malignancies. Myeloablative regimens used for disease control are associated with acute and long-term adverse effects. We used a CD45RA-depleted haploidentical graft for adoptive transfer of memory T cells combined with NK-cell addback and hypothesized that maximizing the graft-versus-leukemia (GVL) effect might allow for reduction in intensity of conditioning regimen. Methods: In this phase II clinical trial (NCT01807611), 72 patients with hematological malignancies (complete remission (CR)1: 25, ≥ CR2: 28, refractory disease: 19) received haploidentical CD34 + enriched and CD45RA-depleted hematopoietic progenitor cell grafts followed by NK-cell infusion. Conditioning included fludarabine, thiotepa, melphalan, cyclophosphamide, total lymphoid irradiation, and graft-versus-host disease (GVHD) prophylaxis consisted of a short-course sirolimus or mycophenolate mofetil without serotherapy. Results: The 3-year overall survival (OS) and event-free-survival (EFS) for patients in CR1 were 92% (95% CI:72–98) and 88% (95% CI: 67–96); ≥ CR2 were 81% (95% CI: 61–92) and 68% (95% CI: 47–82) and refractory disease were 32% (95% CI: 11–54) and 20% (95% CI: 6–40). The 3-year EFS for all patients in morphological CR was 77% (95% CI: 64–87) with no difference amongst recipients with or without minimal residual disease (P = 0.2992). Immune reconstitution was rapid, with mean CD3 and CD4 T-cell counts of 410/μL and 140/μL at day + 30. Cumulative incidence of acute GVHD and chronic GVHD was 36% and 26% but most patients with acute GVHD recovered rapidly with therapy. Lower rates of grade III-IV acute GVHD were observed with NK-cell alloreactive donors (P = 0.004), and higher rates of moderate/severe chronic GVHD occurred with maternal donors (P = 0.035). Conclusion: The combination of a CD45RA-depleted graft and NK-cell addback led to robust immune reconstitution maximizing the GVL effect and allowed for use of a submyeloablative, TBI-free conditioning regimen that was associated with excellent EFS resulting in promising long-term outcomes in this high-risk population. The trial is registered at ClinicalTrials.gov (NCT01807611). [ABSTRACT FROM AUTHOR]

Published
2024
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17. SF3B1 mutation and ATM deletion co-drive leukemogenesis via centromeric R-loop dysregulation

Author

Cusan, Martina, primary, Shen, Haifeng, additional, Zhang, Bo, additional, Liao, Aijun, additional, Yang, Lu, additional, Jin, Meiling, additional, Fernandez, Mike, additional, Iyer, Prajish, additional, Wu, Yiming, additional, Hart, Kevyn L., additional, Gutierrez, Catherine, additional, Nik, Sara, additional, Pruett-Miller, Shondra M., additional, Stark, Jeremy, additional, Obeng, Esther A., additional, Bowman, Teresa V., additional, Wu, Catherine J., additional, Lin, Ren-Jang, additional, and Wang, Lili, additional

Published
2023
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18. Congenital macrothrombocytopenia with focal myelofibrosis due to mutations in human G6b-B is rescued in humanized mice

Author

Hofmann, Inga, Geer, Mitchell J., Vögtle, Timo, Crispin, Andrew, Campagna, Dean R., Barr, Alastair, Calicchio, Monica L., Heising, Silke, van Geffen, Johanna P., Kuijpers, Marijke J.E., Heemskerk, Johan W.M., Eble, Johannes A., Schmitz-Abe, Klaus, Obeng, Esther A., Douglas, Michael, Freson, Kathleen, Pondarré, Corinne, Favier, Rémi, Jarvis, Gavin E., Markianos, Kyriacos, Turro, Ernest, Ouwehand, Willem H., Mazharian, Alexandra, Fleming, Mark D., and Senis, Yotis A.

Published
2018
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20. Supplementary Excel Tables from Integrative Genomic Analysis of Pediatric Myeloid-Related Acute Leukemias Identifies Novel Subtypes and Prognostic Indicators

Author

Fornerod, Maarten, primary, Ma, Jing, primary, Noort, Sanne, primary, Liu, Yu, primary, Walsh, Michael P., primary, Shi, Lei, primary, Nance, Stephanie, primary, Liu, Yanling, primary, Wang, Yuanyuan, primary, Song, Guangchun, primary, Lamprecht, Tamara, primary, Easton, John, primary, Mulder, Heather L., primary, Yergeau, Donald, primary, Myers, Jacquelyn, primary, Kamens, Jennifer L., primary, Obeng, Esther A., primary, Pigazzi, Martina, primary, Jarosova, Marie, primary, Kelaidi, Charikleia, primary, Polychronopoulou, Sophia, primary, Lamba, Jatinder K., primary, Baker, Sharyn D., primary, Rubnitz, Jeffrey E., primary, Reinhardt, Dirk, primary, van den Heuvel-Eibrink, Marry M., primary, Locatelli, Franco, primary, Hasle, Henrik, primary, Klco, Jeffery M., primary, Downing, James R., primary, Zhang, Jinghui, primary, Pounds, Stanley, primary, Zwaan, C. Michel, primary, and Gruber, Tanja A., primary

Published
2023
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21. Supplementary Tables and Figures from Integrative Genomic Analysis of Pediatric Myeloid-Related Acute Leukemias Identifies Novel Subtypes and Prognostic Indicators

Author

Fornerod, Maarten, primary, Ma, Jing, primary, Noort, Sanne, primary, Liu, Yu, primary, Walsh, Michael P., primary, Shi, Lei, primary, Nance, Stephanie, primary, Liu, Yanling, primary, Wang, Yuanyuan, primary, Song, Guangchun, primary, Lamprecht, Tamara, primary, Easton, John, primary, Mulder, Heather L., primary, Yergeau, Donald, primary, Myers, Jacquelyn, primary, Kamens, Jennifer L., primary, Obeng, Esther A., primary, Pigazzi, Martina, primary, Jarosova, Marie, primary, Kelaidi, Charikleia, primary, Polychronopoulou, Sophia, primary, Lamba, Jatinder K., primary, Baker, Sharyn D., primary, Rubnitz, Jeffrey E., primary, Reinhardt, Dirk, primary, van den Heuvel-Eibrink, Marry M., primary, Locatelli, Franco, primary, Hasle, Henrik, primary, Klco, Jeffery M., primary, Downing, James R., primary, Zhang, Jinghui, primary, Pounds, Stanley, primary, Zwaan, C. Michel, primary, and Gruber, Tanja A., primary

Published
2023
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22. Data from Integrative Genomic Analysis of Pediatric Myeloid-Related Acute Leukemias Identifies Novel Subtypes and Prognostic Indicators

Author

Fornerod, Maarten, primary, Ma, Jing, primary, Noort, Sanne, primary, Liu, Yu, primary, Walsh, Michael P., primary, Shi, Lei, primary, Nance, Stephanie, primary, Liu, Yanling, primary, Wang, Yuanyuan, primary, Song, Guangchun, primary, Lamprecht, Tamara, primary, Easton, John, primary, Mulder, Heather L., primary, Yergeau, Donald, primary, Myers, Jacquelyn, primary, Kamens, Jennifer L., primary, Obeng, Esther A., primary, Pigazzi, Martina, primary, Jarosova, Marie, primary, Kelaidi, Charikleia, primary, Polychronopoulou, Sophia, primary, Lamba, Jatinder K., primary, Baker, Sharyn D., primary, Rubnitz, Jeffrey E., primary, Reinhardt, Dirk, primary, van den Heuvel-Eibrink, Marry M., primary, Locatelli, Franco, primary, Hasle, Henrik, primary, Klco, Jeffery M., primary, Downing, James R., primary, Zhang, Jinghui, primary, Pounds, Stanley, primary, Zwaan, C. Michel, primary, and Gruber, Tanja A., primary

Published
2023
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23. Supplementary table 1 from Nonsense-Mediated RNA Decay Is a Unique Vulnerability of Cancer Cells Harboring SF3B1 or U2AF1 Mutations

Author

Cheruiyot, Abigael, primary, Li, Shan, primary, Nonavinkere Srivatsan, Sridhar, primary, Ahmed, Tanzir, primary, Chen, Yuhao, primary, Lemacon, Delphine S., primary, Li, Ying, primary, Yang, Zheng, primary, Wadugu, Brian A., primary, Warner, Wayne A., primary, Pruett-Miller, Shondra M., primary, Obeng, Esther A., primary, Link, Daniel C., primary, He, Dalin, primary, Xiao, Fei, primary, Wang, Xiaowei, primary, Bailis, Julie M., primary, Walter, Matthew J., primary, and You, Zhongsheng, primary

Published
2023
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24. Supplementary table 3 from Nonsense-Mediated RNA Decay Is a Unique Vulnerability of Cancer Cells Harboring SF3B1 or U2AF1 Mutations

Author

Cheruiyot, Abigael, primary, Li, Shan, primary, Nonavinkere Srivatsan, Sridhar, primary, Ahmed, Tanzir, primary, Chen, Yuhao, primary, Lemacon, Delphine S., primary, Li, Ying, primary, Yang, Zheng, primary, Wadugu, Brian A., primary, Warner, Wayne A., primary, Pruett-Miller, Shondra M., primary, Obeng, Esther A., primary, Link, Daniel C., primary, He, Dalin, primary, Xiao, Fei, primary, Wang, Xiaowei, primary, Bailis, Julie M., primary, Walter, Matthew J., primary, and You, Zhongsheng, primary

Published
2023
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25. Supplementary figures and legends from Nonsense-Mediated RNA Decay Is a Unique Vulnerability of Cancer Cells Harboring SF3B1 or U2AF1 Mutations

Author

Cheruiyot, Abigael, primary, Li, Shan, primary, Nonavinkere Srivatsan, Sridhar, primary, Ahmed, Tanzir, primary, Chen, Yuhao, primary, Lemacon, Delphine S., primary, Li, Ying, primary, Yang, Zheng, primary, Wadugu, Brian A., primary, Warner, Wayne A., primary, Pruett-Miller, Shondra M., primary, Obeng, Esther A., primary, Link, Daniel C., primary, He, Dalin, primary, Xiao, Fei, primary, Wang, Xiaowei, primary, Bailis, Julie M., primary, Walter, Matthew J., primary, and You, Zhongsheng, primary

Published
2023
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26. Supplementary methods from Nonsense-Mediated RNA Decay Is a Unique Vulnerability of Cancer Cells Harboring SF3B1 or U2AF1 Mutations

Author

Cheruiyot, Abigael, primary, Li, Shan, primary, Nonavinkere Srivatsan, Sridhar, primary, Ahmed, Tanzir, primary, Chen, Yuhao, primary, Lemacon, Delphine S., primary, Li, Ying, primary, Yang, Zheng, primary, Wadugu, Brian A., primary, Warner, Wayne A., primary, Pruett-Miller, Shondra M., primary, Obeng, Esther A., primary, Link, Daniel C., primary, He, Dalin, primary, Xiao, Fei, primary, Wang, Xiaowei, primary, Bailis, Julie M., primary, Walter, Matthew J., primary, and You, Zhongsheng, primary

Published
2023
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27. Supplementary table 2 from Nonsense-Mediated RNA Decay Is a Unique Vulnerability of Cancer Cells Harboring SF3B1 or U2AF1 Mutations

Author

Cheruiyot, Abigael, primary, Li, Shan, primary, Nonavinkere Srivatsan, Sridhar, primary, Ahmed, Tanzir, primary, Chen, Yuhao, primary, Lemacon, Delphine S., primary, Li, Ying, primary, Yang, Zheng, primary, Wadugu, Brian A., primary, Warner, Wayne A., primary, Pruett-Miller, Shondra M., primary, Obeng, Esther A., primary, Link, Daniel C., primary, He, Dalin, primary, Xiao, Fei, primary, Wang, Xiaowei, primary, Bailis, Julie M., primary, Walter, Matthew J., primary, and You, Zhongsheng, primary

Published
2023
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29. 3138 – EPIGENETIC REGULATORS TET2 AND POLYCOMB REPRESSIVE COMPLEX 2 (PRC2) COORDINATE GENE EXPRESSION IN MYELODYSPLASTIC SYNDROME (MDS)

Author

Myers, Jacquelyn, primary, Henriet, Elodie, additional, Wallace, LaShanale, additional, Metidji, Amina, additional, Skorupa, Jordan, additional, Leal-Cervantes, Ana, additional, Pruett-Miller, Shondra, additional, Fan, Yiping, additional, Iacobucci, Ilaria, additional, Haferlach, Torsten, additional, Mullighan, Charles, additional, and Obeng, Esther, additional

Published
2023
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30. An inflammatory state remodels the immune microenvironment and improves risk stratification in acute myeloid leukemia

Author

Lasry, Audrey, primary, Nadorp, Bettina, additional, Fornerod, Maarten, additional, Nicolet, Deedra, additional, Wu, Huiyun, additional, Walker, Christopher J., additional, Sun, Zhengxi, additional, Witkowski, Matthew T., additional, Tikhonova, Anastasia N., additional, Guillamot-Ruano, Maria, additional, Cayanan, Geraldine, additional, Yeaton, Anna, additional, Robbins, Gabriel, additional, Obeng, Esther A., additional, Tsirigos, Aristotelis, additional, Stone, Richard M., additional, Byrd, John C., additional, Pounds, Stanley, additional, Carroll, William L., additional, Gruber, Tanja A., additional, Eisfeld, Ann-Kathrin, additional, and Aifantis, Iannis, additional

Published
2022
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31. Venetoclax-based therapy as a bridge to allogeneic hematopoietic cell transplantation in children with relapsed/refractory AML

Author

Pfeiffer, Thomas, primary, Li, Ying, additional, Ashcraft, Emily, additional, Karol, Seth E., additional, Rubnitz, Jeffrey E., additional, Epperly, Rebecca, additional, Madden, Renee, additional, Mamcarz, Ewelina, additional, Obeng, Esther, additional, Qudeimat, Amr, additional, Sharma, Akshay, additional, Srinivasan, Ashok, additional, Suliman, Ali, additional, Talleur, Aimee C., additional, Velasquez, M. Paulina, additional, Gottschalk, Stephen, additional, Triplett, Brandon M., additional, and Naik, Swati, additional

Published
2022
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34. CD45RA Depleted T-Cell Addback and Prophylactic Blinatumomab Administration Following Tcrαβ/CD19-Depleted Haploidentical Transplantation in Pediatric Patients with High Risk Acute Leukemia

Author

Naik, Swati, primary, Li, Ying, additional, Madden, Renee, additional, Mamcarz, Ewelina, additional, Srinivasan, Ashok, additional, Sharma, Akshay, additional, Talleur, Aimee C, additional, Qudeimat, Amr, additional, Suliman, Ali, additional, Epperly, Rebecca, additional, Obeng, Esther A, additional, Velasquez, Mireya Paulina, additional, Hijano, Diego, additional, Marón, Gabriela M., additional, Metais, Jean-Yves, additional, Gottschalk, Stephen, additional, and Triplett, Brandon M., additional

Published
2022
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35. CD45RA-Depleted Haploidentical Transplantation Combined with NK Cell Addback Results in Promising Long-Term Outcomes in Pediatric Patients with High-Risk Hematologic Malignancies

Author

Naik, Swati, primary, Talleur, Aimee C, additional, Li, Ying, additional, Madden, Renee, additional, Mamcarz, Ewelina, additional, Qudeimat, Amr, additional, Sharma, Akshay, additional, Srinivasan, Ashok, additional, Suliman, Ali, additional, Epperly, Rebecca, additional, Obeng, Esther A, additional, Velasquez, Mireya Paulina, additional, Hijano, Diego, additional, Marón, Gabriela M., additional, Metais, Jean-Yves, additional, Gottschalk, Stephen, additional, and Triplett, Brandon M., additional

Published
2022
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36. Venetoclax-Based Combination Therapy As a Bridge to Allogeneic Hematopoietic Stem Cell Transplant in Children with Relapsed/Refractory AML

Author

Pfeiffer, Thomas, primary, Li, Ying, additional, Karol, Seth E, additional, Rubnitz, Jeffrey E, additional, Epperly, Rebecca, additional, Madden, Renee, additional, Mamcarz, Ewelina, additional, Obeng, Esther A, additional, Qudeimat, Amr, additional, Sharma, Akshay, additional, Srinivasan, Ashok, additional, Suliman, Ali, additional, Talleur, Aimee C, additional, Velasquez, Mireya Paulina, additional, Gottschalk, Stephen, additional, Triplett, Brandon M., additional, and Naik, Swati, additional

Published
2022
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41. CD45RA-Depleted Haploidentical Transplantation Combined with NK Cell Addback Results in Promising Long-Term Outcomes in Pediatric Patients with High-Risk Hematologic Malignancies

Author

Naik, Swati, primary, Talleur, Aimee C, additional, Li, Ying, additional, Madden, Renee M., additional, Mamcarz, Ewelina, additional, Qudeimat, Amr, additional, Sharma, Akshay, additional, Srinivasan, Ashok, additional, Suliman, Ali Y, additional, Epperly, Rebecca, additional, Obeng, Esther A., additional, Velasquez, Mireya Paulina, additional, Hijano, Diego, additional, Maron, Gabriela, additional, Gottschalk, Stephen, additional, and Triplett, Brandon M, additional

Published
2021
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42. CD45RO+ T-Cell Add Back and Prophylactic Blinatumomab Administration Post Tcrαβ/CD19-Depleted Haploidentical Transplantation in Pediatric Patients with High Risk Acute Leukemia

Author

Naik, Swati, primary, Madden, Renee M., additional, Mamcarz, Ewelina, additional, Srinivasan, Ashok, additional, Sharma, Akshay, additional, Talleur, Aimee C, additional, Epperly, Rebecca, additional, Qudeimat, Amr, additional, Suliman, Ali Y, additional, Obeng, Esther A., additional, Velasquez, Mireya Paulina, additional, Hijano, Diego, additional, Maron, Gabriela, additional, Li, Ying, additional, Gottschalk, Stephen, additional, and Triplett, Brandon M, additional

Published
2021
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43. Selective Targeting of Splicing Factor Mutant Hematopoietic Stem and Progenitor Cells Via STAT3 Inhibition

Author

Potts, Kathryn S, primary, Cameron, Rosannah C., additional, Ghazale, Noura, additional, Gupta, Varun, additional, Barajas, Juan Martin, additional, Wallace, LaShanale, additional, Leal-Cervantes, Ana, additional, Aluri, Srinivas, additional, Pradhan, Kith, additional, McKinstry, Mia, additional, Bai, Xiaoying, additional, Choudhary, Gaurav S, additional, Shastri, Aditi, additional, Verma, Amit, additional, Obeng, Esther A., additional, and Bowman, Teresa V., additional

Published
2021
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45. Integrative Genomic Analysis of Pediatric Myeloid-Related Acute Leukemias Identifies Novel Subtypes and Prognostic Indicators

Author

Fornerod, Maarten, primary, Ma, Jing, additional, Noort, Sanne, additional, Liu, Yu, additional, Walsh, Michael P., additional, Shi, Lei, additional, Nance, Stephanie, additional, Liu, Yanling, additional, Wang, Yuanyuan, additional, Song, Guangchun, additional, Lamprecht, Tamara, additional, Easton, John, additional, Mulder, Heather L., additional, Yergeau, Donald, additional, Myers, Jacquelyn, additional, Kamens, Jennifer L., additional, Obeng, Esther A., additional, Pigazzi, Martina, additional, Jarosova, Marie, additional, Kelaidi, Charikleia, additional, Polychronopoulou, Sophia, additional, Lamba, Jatinder K., additional, Baker, Sharyn D., additional, Rubnitz, Jeffrey E., additional, Reinhardt, Dirk, additional, van den Heuvel-Eibrink, Marry M., additional, Locatelli, Franco, additional, Hasle, Henrik, additional, Klco, Jeffery M., additional, Downing, James R., additional, Zhang, Jinghui, additional, Pounds, Stanley, additional, Zwaan, C. Michel, additional, and Gruber, Tanja A., additional

Published
2021
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46. 3116 – SELECTIVE TARGETING OF SPLICING FACTOR MUTANT HEMATOPOIETIC STEM AND PROGENITOR CELLS VIA STAT3 INHIBITION

Author

Potts, Kathryn, primary, Cameron, Rosannah, additional, Barajas, Juan, additional, Cervantes, Ana Leal, additional, Wallace, LaShanale, additional, Gupta, Varun, additional, Ghazale, Noura, additional, Aluri, Srinivas, additional, McKinstry, Mia, additional, Bai, Xiaoying, additional, Chaudhary, Gaurav, additional, Shastri, Aditi, additional, Verma, Amit, additional, Obeng, Esther, additional, and Bowman, Teresa, additional

Published
2021
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47. Nonsense-Mediated RNA Decay Is a Unique Vulnerability of Cancer Cells Harboring SF3B1 or U2AF1 Mutations

Author

Cheruiyot, Abigael, primary, Li, Shan, additional, Nonavinkere Srivatsan, Sridhar, additional, Ahmed, Tanzir, additional, Chen, Yuhao, additional, Lemacon, Delphine S., additional, Li, Ying, additional, Yang, Zheng, additional, Wadugu, Brian A., additional, Warner, Wayne A., additional, Pruett-Miller, Shondra M., additional, Obeng, Esther A., additional, Link, Daniel C., additional, He, Dalin, additional, Xiao, Fei, additional, Wang, Xiaowei, additional, Bailis, Julie M., additional, Walter, Matthew J., additional, and You, Zhongsheng, additional

Published
2021
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49. Engineering naturally occurring CD7−T cells for the immunotherapy of hematological malignancies

Author

Freiwan, Abdullah, Zoine, Jaquelyn T., Crawford, Jeremy Chase, Vaidya, Abishek, Schattgen, Stefan A., Myers, Jacquelyn A., Patil, Sagar L., Khanlari, Mahsa, Inaba, Hiroto, Klco, Jeffery M., Mullighan, Charles G., Krenciute, Giedre, Chockley, Peter J., Naik, Swati, Langfitt, Deanna M., Mamonkin, Maksim, Obeng, Esther A., Thomas, Paul G., Gottschalk, Stephen, and Velasquez, M. Paulina

Abstract

•Naturally occurring CD7 negative T cells are functional effector T cells that can be used for chimeric antigen receptor therapy.•CD7 negative T cells expressing a CD7-CAR have robust antitumor activity and bypass fratricide.

Published
2022
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50. Nonsense Mediated RNA Decay Is a Unique Vulnerability of Cancer Cells with SF3B1 and U2AF1 Mutations

Author

Cheruiyot, Abigael, primary, Li, Shan, additional, Srivatsan, Sridhar Nonavinkere, additional, Ahmed, Tanzir, additional, Chen, Yuhao, additional, Lemacon, Delphine Sangotokun, additional, Li, Ying, additional, Yang, Zheng, additional, Wadugu, Brian A., additional, Warner, Wayne, additional, Pruett-Miller, Shondra M., additional, Obeng, Esther A., additional, Link, Daniel C., additional, He, Dalin, additional, Xiao, Fei, additional, Wang, Xiaowei, additional, Bailis, Julie M., additional, Walter, Matthew J., additional, and You, Zhongsheng, additional

Published
2021
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