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1. Prospective evaluation of minimal residual disease in the phase II FORTE trial: a head-to-head comparison between multiparameter flow cytometry and next-generation sequencing

Author

Oliva, Stefania, Genuardi, Elisa, Paris, Laura, D'Agostino, Mattia, Rogers, Jennifer, Rota-Scalabrini, Delia, Jacob, Allison P., Patriarca, Francesca, Luppi, Mario, Bertazzoni, Paola, Velluti, Cristina, Capra, Andrea, Saraci, Elona, Rossi, Marco, Allegra, Alessandro, Mina, Roberto, Gentile, Massimo, Kirsch, Ilan R., Belotti, Angelo, Cavo, Michele, Bruno, Benedetto, Musto, Pellegrino, Boccadoro, Mario, Zamagni, Elena, and Gay, Francesca

Published
2023
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3. Carfilzomib induction, consolidation, and maintenance with or without autologous stem-cell transplantation in patients with newly diagnosed multiple myeloma: pre-planned cytogenetic subgroup analysis of the randomised, phase 2 FORTE trial

Author

Mina, Roberto, Musto, Pellegrino, Rota-Scalabrini, Delia, Paris, Laura, Gamberi, Barbara, Palmas, Angelo, Aquino, Sara, de Fabritiis, Paolo, Giuliani, Nicola, De Rosa, Luca, Gozzetti, Alessandro, Cellini, Claudia, Bertamini, Luca, Capra, Andrea, Oddolo, Daniela, Vincelli, Iolanda Donatella, Ronconi, Sonia, Pavone, Vincenzo, Pescosta, Norbert, Cea, Michele, Fioritoni, Francesca, Ballanti, Stelvio, Grasso, Mariella, Zamagni, Elena, Belotti, Angelo, Boccadoro, Mario, and Gay, Francesca

Published
2023
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5. Evaluating barriers to reaching women with public health information in remote communities in Mali.

Author

Jones, Robert T., Spencer, Freya I., Paris, Laura A., Soumaïla, Diarra, Kamara, Nanthilde, Hiscox, Alexandra, and Logan, James G.

Subjects
COMMUNITY health workers, COMMUNITY centers, MOBILE operating systems, MEDICAL centers, TRUST
Abstract

Telecommunications offers an alternative or supplement to community-based interventions as a means of extending healthcare services and improving health outcomes in remote settings but can fail to reach target communities and achieve the desired impact if barriers to access are not overcome. We conducted seven focus group discussions and 26 interviews with community health workers, community leaders, and female members of the public who declared that they had or had not previously accessed free audio health messages provided via a mobile platform in two rural communities of Mali, Koulikoro and Bougouni. A content analysis showed that participants accessed and trusted health information from a range of sources, including radio, telephone and television, as well as town criers, local relays and community health centres. Barriers to access faced by women included economic factors, lack of network or electricity, and social factors such as illiteracy, cultural restrictions and being unaware of mobile communication. Through analysis and interpretation of the participants' responses, we have made recommendations for future campaigns for the dissemination of health-related information for women in remote settings. [ABSTRACT FROM AUTHOR]

Published
2024
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6. Anticoagulation and Antiplatelet Regimen in Cardiac Transplant. Clinical Characteristics, Outcomes, and Blood Product Transfusion.

Author

Groba Marco, Maria del Val, Saavedra Santana, Pedro, Gonzalez del Castillo, Luz Maria, Galvan Ruiz, Mario, de Fernandez de Sanmamed, Miguel, Urso, Stefano, Guerra Hernández, Elisabet, Quintana Paris, Laura, Tout Castellano, Michelle, Romero Lujan, Jose Luis, Caballero Dorta, Eduardo Jose, Guerra Dominguez, Luisa Maria, and Garcia Quintana, Antonio

Subjects
HEART transplantation, BLOOD transfusion, BLOOD platelet transfusion, BLOOD products, ANTICOAGULANTS, ERYTHROCYTES
Abstract

Background: We aimed to evaluate the characteristics, clinical outcomes, and blood product transfusion (BPT) rates of patients undergoing cardiac transplant (CT) while receiving uninterrupted anticoagulation and antiplatelet therapy. Methods: A retrospective, single‐center, and observational study of adult patients who underwent CT was performed. Patients were classified into four groups: (1) patients without anticoagulation or antiplatelet therapy (control), (2) patients on antiplatelet therapy (AP), (3) patients on vitamin K antagonists (AVKs), and (4) patients on dabigatran (dabigatran). The primary endpoints were reoperation due to bleeding and perioperative BPT rates (packed red blood cells (PRBC), fresh frozen plasma, platelets). Secondary outcomes assessed included morbidity and mortality‐related events. Results: Of the 55 patients included, 6 (11%) received no therapy (control), 8 (15%) received antiplatelet therapy, 15 (27%) were on AVKs, and 26 (47%) were on dabigatran. There were no significant differences in the need for reoperation or other secondary morbidity‐associated events. During surgery patients on dabigatran showed lower transfusion rates of PRBC (control 100%, AP 100%, AVKs 73%, dabigatran 50%, p = 0.011) and platelets (control 100%, AP 100%, AVKs 100%, dabigatran 69%, p = 0.019). The total intraoperative number of BPT was also the lowest in the dabigatran group (control 5.5 units, AP 5 units, AVKs 6 units, dabigatran 3 units; p = 0.038); receiving significantly less PRBC (control 2.5 units, AP 3 units, AVKs 2 units, dabigatran 0.5 units; p = 0.011). A Poisson multivariate analysis showed that only treatment on dabigatran reduces PRBC requirements during surgery, with an expected reduction of 64.5% (95% CI: 32.4%–81.4%). Conclusions: In patients listed for CT requiring anticoagulation due to nonvalvular atrial fibrillation, the use of dabigatran and its reversal with idarucizumab significantly reduces intraoperative BPT demand. [ABSTRACT FROM AUTHOR]

Published
2024
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7. Humanistic burden of haemophilia A without inhibitors: A cross‐sectional analysis of the HemoLIFE study.

Author

Álvarez‐Román, María Teresa, Nuñez Vazquez, Ramiro Jose, Benitez Hidalgo, Olga, Quintana Paris, Laura, Entrena Ureña, Laura, Lopez Jaime, Francisco Jose, la De Corte‐Rodríguez, Hortensia, García Dasí, María, Bosch, Pau, Mingot Castellano, María Eva, Guerra Garaeta, Itziar, and Soto‐Ortega, Inmaculada

Subjects
HEMOPHILIA, CROSS-sectional method, HEMOPHILIACS, CHILD patients, LABOR productivity
Abstract

Aim: To evaluate the impact of haemophilia A without inhibitors on humanistic outcomes in patients and caregivers. Herein, we report a cross‐sectional analysis of the baseline data of persons with haemophilia (PWH) participating in the prospective study HEMOLIFE. Methods: These data are part of a prospective, observational, and multicentre study currently being conducted in 20 hospitals in Spain by haematologists. We included subjects 12 years or older diagnosed with haemophilia. The evaluations included the Maladjustment Scale, Haemophilia–Specific Quality of Life Questionnaire for Adults (HaemoQol)/HaemoQol Short Form (Children), haemophilia‐specific version of the Work Productivity and Impairment Questionnaire plus the Classroom Impairment Questionnaire (WPAI+CIQ:HS), Haemophilia Activity List (HAL)/Paediatric Haemophilia Activities List (pedHAL), visual analogue scale (VAS) for evaluating pain, Coping Pain Questionnaire–Reduced (CAD‐R), and Hospital Anxiety and Depression Scale (HADS). Results: A total of 81 PWH were recruited at 18 centres; 66 PWH were ≥18 years (i.e., adults), and PWH 15 were <18 years (i.e., paediatric patients). Out of the 79 evaluable subjects, 16 (20%) showed an impact of haemophilia on daily life, and the areas most affected were "leisure time" (58% showed maladjustment) and "work/studies" (47% showed maladjustment). Patients reported a higher impact of haemophilia on quality of life (mean [SD] of the transformed score) in the dimensions of "sport" (49.4 [28.6]), "physical health" (40.5 [25.8]) and "future" (37.7 [28.9]). In adults, according to HAL scores, greater impairment of function was observed in "lying/sitting/kneeling/standing," "function of legs" and "leisure activities and sports," with mean normalized scores of 64.7, 65.1 and 69.0, respectively. Productivity was mostly impacted by presenteeism. The pain was infrequent and moderate. According to the HADS scores, nine (11.5%) patients had clinical anxiety and depression. Conclusion: PWH without inhibitors exhibited impairments in adjustment, quality of life and functionality, especially related to leisure and sports activities, and exhibit relevant levels of anxiety and depression. [ABSTRACT FROM AUTHOR]

Published
2024
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9. Predictors of unsustained measurable residual disease negativity in patients with multiple myeloma

Author

D’Agostino, Mattia, primary, Bertuglia, Giuseppe, additional, Rota-Scalabrini, Delia, additional, Belotti, Angelo, additional, Morè, Sonia, additional, Corradini, Paolo, additional, Oliva, Stefania, additional, Ledda, Antonio, additional, Grasso, Mariella, additional, Pavone, Vincenzo, additional, Ronconi, Sonia, additional, Vincelli, Iolanda Donatella, additional, Ballanti, Stelvio, additional, Velluti, Cristina, additional, Cellini, Claudia, additional, Gozzetti, Alessandro, additional, Palmas, Angelo D., additional, Gamberi, Barbara, additional, Mancuso, Katia, additional, Paris, Laura, additional, Zambello, Renato, additional, Petrucci, Maria Teresa, additional, Bruno, Benedetto, additional, Musto, Pellegrino, additional, and Gay, Francesca, additional

Published
2024
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10. A review of Musca sorbens(Diptera: Muscidae) and Musca domesticabehavior and responses to chemical and visual cues

Author

Jones, Robert T, Fagbohun, Ifeoluwa K, Spencer, Freya I, Chen-Hussey, Vanessa, Paris, Laura A, Logan, James G, and Hiscox, Alexandra

Abstract

Muscaflies (Diptera: Muscidae) have been found culpable in the mechanical transmission of several infectious agents, including viruses, bacteria, protozoans, and helminths, particularly in low-income settings in tropical regions. In large numbers, these flies can negatively impact the health of communities and their livestock through the transmission of pathogens. In some parts of the world, Musca sorbensis of particular importance because it has been linked with the transmission of trachoma, a leading cause of preventable and irreversible blindness or visual impairment caused by Chlamydia trachomatis, but the contribution these flies make to trachoma transmission has not been quantified and even less is known for other pathogens. Current tools for control and monitoring of house flies remain fairly rudimentary and have focused on the use of environmental management, insecticides, traps, and sticky papers. Given that the behaviors of flies are triggered by chemical cues from their environment, monitoring approaches may be improved by focusing on those activities that are associated with nuisance behaviors or with potential pathogen transmission, and there are opportunities to improve fly control by exploiting behaviors toward semiochemicals that act as attractants or repellents. We review current knowledge on the odor and visual cues that affect the behavior of M. sorbensand Musca domestica, with the aim of better understanding how these can be exploited to support disease monitoring and guide the development of more effective control strategies.

Published
2024
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11. Ixazomib-based induction regimens plus ixazomib maintenance in transplant-ineligible, newly diagnosed multiple myeloma: the phase II, multi-arm, randomized UNITO-EMN10 trial

Author

Mina, Roberto, Falcone, Antonietta Pia, Bringhen, Sara, Liberati, Anna Marina, Pescosta, Norbert, Petrucci, Maria Teresa, Ciccone, Giovannino, Capra, Andrea, Patriarca, Francesca, Rota-Scalabrini, Delia, Bonello, Francesca, Musolino, Caterina, Cea, Michele, Zambello, Renato, Tacchetti, Paola, Belotti, Angelo, Cellini, Claudia, Paris, Laura, Grasso, Mariella, Aquino, Sara, De Paoli, Lorenzo, De Sabbata, Giovanni, Ballanti, Stelvio, Offidani, Massimo, Boccadoro, Mario, Monaco, Federico, Corradini, Paolo, and Larocca, Alessandra

Published
2021
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12. The timing of plerixafor addition to G-Csf and chemotherapy affects immunological recovery after autologous stem cell transplant in multiple myeloma

Author

Tolomelli, Giulia, Mancuso, Katia, Tacchetti, Paola, Patriarca, Francesca, Galli, Monica, Pantani, Lucia, Zannetti, Beatrice, Motta, Maria Rosa, Rizzi, Simonetta, Dan, Elisa, Sinigaglia, Barbara, Giudice, Valeria, Olmo, Andrea, Arpinati, Mario, Chirumbolo, Gabriella, Fanin, Renato, Lewis, Russell E., Paris, Laura, Bonifazi, Francesca, Cavo, Michele, Curti, Antonio, and Lemoli, Roberto M.

Published
2020
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13. P-034 Alnuctamab (ALNUC; BMS-986349; CC-93269), a BCMA × CD3 T-cell engager, in patients (pts) with relapsed/refractory multiple myeloma (RRMM): latest results from a phase 1 first-in-human clinical study

Author

Costa, Luciano, primary, Bar, Noffar, additional, Mateos, Maria-Victoria, additional, Ribas, Paz, additional, Hansson, Markus, additional, Paris, Laura, additional, Hofmeister, Craig, additional, Rodriguez-Otero, Paula, additional, Bermúdez, Maria Aranzazu, additional, Santoro, Armando, additional, Yee, Andrew, additional, Creignou, Maria, additional, Encinas, Cristina, additional, Cerchione, Claudio, additional, de la Rubia, Javier, additional, Oriol, Albert, additional, Ferstl, Barbara, additional, Besemer, Britta, additional, Chen, Jinjie, additional, Boss, Isaac, additional, Gaudy, Allison, additional, Hsu, Kevin, additional, Godwin, Colin, additional, San-Miguel, Jesús, additional, and Wong, Sandy, additional

Published
2023
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14. P895: DARATUMUMAB PLUS POMALIDOMIDE AND DEXAMETHASONE (DPD) IN PATIENTS WITH RELAPSED/REFRACTORY MULTIPLE MYELOMA AND 17P DELETION: UPDATED ANALYSIS OF THE DEDALO PHASE II TRIAL

Author

Montefusco, Vittorio, primary, Maria Cafro, Anna, additional, Margiotta-Casaluci, Gloria, additional, Patriarca, Francesca, additional, Mina, Roberto, additional, D’agostino5, Mattia, additional, Palma, Anna Benedetta Dalla, additional, Rizzi, Rita, additional, Genua, Angelo, additional, Fazio, Francesca, additional, Paris, Laura, additional, Belotti, Angelo, additional, Rizzello, Ilaria, additional, Conticello, Concetta, additional, Carlo-Stella, Carmelo, additional, and Boccadoro, Mario, additional

Published
2023
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15. P883: ALNUCTAMAB (ALNUC; BMS-986349; CC-93269), A BCMA × CD3 T-CELL ENGAGER, IN PATIENTS (PTS) WITH RELAPSED/REFRACTORY MULTIPLE MYELOMA (RRMM): LATEST RESULTS FROM A PHASE 1 FIRST-IN-HUMAN CLINICAL STUDY

Author

Wong, Sandy W., primary, Bar, Noffar, additional, Victoria Mateos, María, additional, Ribas, Paz, additional, Hansson, Markus, additional, Paris, Laura, additional, Hofmeister, Craig, additional, Rodriguez-Otero, Paula, additional, Aranzazu Bermúdez, Maria, additional, Santoro, Armando, additional, Yee, Andrew J., additional, Creignou, Maria, additional, Encinas, Cristina, additional, Cerchione, Claudio, additional, de la Rubia, Javier, additional, Oriol, Albert, additional, Ferstl, Barbara, additional, Besemer, Britta, additional, Chen, Jinjie, additional, Chung, Alexander, additional, Boss, Isaac W., additional, Gaudy, Allison, additional, LI, Shaoyi, additional, Hsu, Kevin, additional, Godwin, Colin, additional, Burgess, Michael R., additional, San-Miguel, Jesús, additional, and Jose Costa, Luciano, additional

Published
2023
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16. When Cannabis sativa L. Turns Purple: Biosynthesis and Accumulation of Anthocyanins

Author

Paris, Laura Bassolino, Flavia Fulvio, Chiara Pastore, Federica Pasini, Tullia Gallina Toschi, Ilaria Filippetti, and Roberta

Subjects
Cannabis sativa, keracyanin, transcription factors, decorating enzymes, MYB, MATE, HPLC-MS/MS, circular economy
Abstract

Environmental cues elicit anthocyanin synthesis in plant vegetative and reproductive tissues. Their accumulation in different organs accounts for their diverse biological functions, mainly related to their antioxidant properties, and it depends on a temporally and spatially regulated mechanism controlled by the action of a well-known multi-transcription factor complex. Despite the highly recognizable value of Cannabis sativa L. as a natural biorefinery of phytochemicals, very little information is known on anthocyanin pigmentation in this species. In this work, a targeted quantification of anthocyanins via HPLC-MS/MS, combined with the transcriptional profile via RT-qPCR of genes encoding for structural and decorating enzymes and regulatory transcription factors in different C. sativa tissues, help gain insights into the anthocyanin pathway in this species. To the best of our knowledge, this is the first report on the identification of cyanidin-3-rutinoside (keracyanin) as the major anthocyanin in C. sativa vegetative and floral tissues. Keracyanin amounts were higher than in small berries, suggesting that Cannabis biomass is a valuable source of colored antioxidants to be exploited in diverse applications. Furthermore, a gene putatively encoding for an anthocyanin DTX35 type transporter and CsTTG1 were identified in silico and their transcriptional levels were assessed via RT-qPCR. The results allow us to provide the first model of anthocyanin regulation in C. sativa, opening a new research scenario in this species for both breeding purposes and phytochemical exploitation.

Published
2023
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18. Alnuctamab (ALNUC; BMS-986349; CC-93269), a B-Cell Maturation Antigen (BCMA) x CD3 T-Cell Engager (TCE), in Patients (pts) with Relapsed/Refractory Multiple Myeloma (RRMM): Results from a Phase 1 First-in-Human Clinical Study

Author

Wong, Sandy W., primary, Bar, Noffar, additional, Paris, Laura, additional, Hofmeister, Craig C, additional, Hansson, Markus, additional, Santoro, Armando, additional, Mateos, Maria-Victoria, additional, Rodríguez-Otero, Paula, additional, Lund, Johan, additional, Encinas, Cristina, additional, Yee, Andrew J., additional, Oriol, Albert, additional, Cerchione, Claudio, additional, de la Rubia, Javier, additional, Ferstl, Barbara, additional, Carlson, Kristina, additional, Ribas, Paz, additional, Bermúdez, Arancha, additional, Boss, Isaac W., additional, Gaudy, Allison, additional, Li, Shaoyi, additional, Hsu, Kevin, additional, Godwin, Colin D., additional, Burgess, Michael R., additional, San-Miguel, Jesús, additional, and Costa, Luciano J., additional

Published
2022
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19. Dedalo: Phase II Study of Daratumumab Plus Pomalidomide and Dexamethasone (DPd) in Patients with Relapsed/Refractory Multiple Myeloma and 17p Deletion

Author

Montefusco, Vittorio, primary, Cafro, Anna Maria, additional, Margiotta Casaluci, Gloria, additional, Patriarca, Francesca, additional, Mina, Roberto, additional, D'Agostino, Mattia, additional, Capra, Andrea, additional, Priola, Claudia, additional, Dalla Palma, Anna Benedetta, additional, Rizzi, Rita, additional, Genua, Angelo, additional, Petrucci, Maria Teresa, additional, Paris, Laura, additional, Belotti, Angelo, additional, Cavo, Michele, additional, Conticello, Concetta, additional, Carlo-Stella, Carmelo, additional, and Boccadoro, Mario, additional

Published
2022
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21. Lenalidomide-based triplet regimens in first relapsed multiple myeloma patients: real-world evidence from a propensity score matched analysis

Author

Mangiacavalli, Silvia, primary, Cartia, Claudio Salvatore, additional, Galli, Monica, additional, Pezzatti, Sara, additional, Belotti, Angelo, additional, Fazio, Francesca, additional, Mina, Roberto, additional, Marcatti, Magda, additional, Cafro, Anna, additional, Zambello, Renato, additional, Paris, Laura, additional, Barilà, Gregorio, additional, Olivares, Cecilia, additional, Pompa, Alessandra, additional, Mazza, Rita, additional, Farina, Francesca, additional, Soldarini, Martina, additional, Benvenuti, Pietro, additional, Pagani, Giuseppina, additional, Palumbo, Michele, additional, Masoni, Valeria, additional, Ferretti, Virginia Valeria, additional, Klersy, Catherine, additional, Arcaini, Luca, additional, and Petrucci, Maria Teresa, additional

Published
2022
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22. High Levels of Circulating Tumor Plasma Cells as a Key Hallmark of Aggressive Disease in Transplant-Eligible Patients With Newly Diagnosed Multiple Myeloma

Author

Bertamini, Luca, primary, Oliva, Stefania, additional, Rota-Scalabrini, Delia, additional, Paris, Laura, additional, Morè, Sonia, additional, Corradini, Paolo, additional, Ledda, Antonio, additional, Gentile, Massimo, additional, De Sabbata, Giovanni, additional, Pietrantuono, Giuseppe, additional, Pascarella, Anna, additional, Tosi, Patrizia, additional, Curci, Paola, additional, Gilestro, Milena, additional, Capra, Andrea, additional, Galieni, Piero, additional, Pisani, Francesco, additional, Annibali, Ombretta, additional, Monaco, Federico, additional, Liberati, Anna Marina, additional, Palmieri, Salvatore, additional, Luppi, Mario, additional, Zambello, Renato, additional, Fazio, Francesca, additional, Belotti, Angelo, additional, Tacchetti, Paola, additional, Musto, Pellegrino, additional, Boccadoro, Mario, additional, and Gay, Francesca, additional

Published
2022
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23. OAB-011: Predictors of unsustained negativity in minimal residual disease (MRD)-negative transplant-eligible newly diagnosed multiple myeloma (MM) patients enrolled in the FORTE trial

Author

D’Agostino, Mattia, primary, Oliva, Stefania, additional, Rota-Scalabrini, Delia, additional, Petrucci, Maria Teresa, additional, Zambello, Renato, additional, De Sabbata, Giovanni, additional, Liberati, Anna Marina, additional, Pietrantuono, Giuseppe, additional, Tosi, Patrizia, additional, Pisani, Francesco, additional, Capra, Andrea, additional, Velluti, Cristina, additional, Galieni, Piero, additional, Annibali, Ombretta, additional, Monaco, Federico, additional, Pascarella, Anna, additional, Palmieri, Salvatore, additional, Luppi, Mario, additional, Cavo, Michele, additional, Paris, Laura, additional, Bruno, Benedetto, additional, Musto, Pellegrino, additional, Boccadoro, Mario, additional, and Gay, Francesca, additional

Published
2022
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24. Complications of Autologous Stem Cell Transplantation in Multiple Myeloma: Results from the CALM Study

Author

Waszczuk-Gajda, Anna, primary, Penack, Olaf, additional, Sbianchi, Giulia, additional, Koster, Linda, additional, Blaise, Didier, additional, Reményi, Péter, additional, Russell, Nigel, additional, Ljungman, Per, additional, Trneny, Marek, additional, Mayer, Jiri, additional, Iacobelli, Simona, additional, Kobbe, Guido, additional, Scheid, Christof, additional, Apperley, Jane, additional, Touzeau, Cyrille, additional, Lenhoff, Stig, additional, Jantunen, Esa, additional, Anagnostopoulos, Achilles, additional, Paris, Laura, additional, Browne, Paul, additional, Thieblemont, Catherine, additional, Schaap, Nicolaas, additional, Sierra, Jorge, additional, Yakoub-Agha, Ibrahim, additional, Garderet, Laurent, additional, Styczynski, Jan, additional, Schoemans, Helene, additional, Moiseev, Ivan, additional, Duarte, Rafael F., additional, Peric, Zinaida, additional, Montoto, Silvia, additional, van Biezen, Anja, additional, Mikulska, Malgorzata, additional, Aljurf, Mahmoud, additional, Ruutu, Tapani, additional, Kröger, Nicolaus, additional, Morris, Curly, additional, Koenecke, Christian, additional, Schoenland, Stefan, additional, and Basak, Grzegorz W., additional

Published
2022
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26. Real-World Patterns of Utilization and Outcome of Market Approved Lenalidomide-Based Triplet Combinations in First Relapsed Multiple Myeloma Patients: Evidence from a Propensity Score Matched Analysis

Author

Mangiacavalli, Silvia, primary, Galli, Monica, additional, Pezzatti, Sara, additional, Belotti, Angelo, additional, Fazio, Francesca, additional, Marcatti, Magda, additional, Cafro, Anna Maria, additional, Mina, Roberto, additional, Zambello, Renato, additional, Paris, Laura, additional, Cartia, Claudio Salvatore, additional, Barilà, Gregorio, additional, Olivares, Cecilia, additional, Pompa, Alessandra, additional, Mazza, Rita, additional, Farina, Francesca, additional, Soldarini, Martina, additional, Benvenuti, Pietro, additional, Lecci, Marica, additional, Ferretti, Virginia Valeria, additional, and Petrucci, Maria Teresa, additional

Published
2021
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27. Safety of outpatient stem cell mobilization with low‐ or intermediate‐dose cyclophosphamide in newly diagnosed multiple myeloma patients

Author

Pompa, Alessandra, primary, Pettine, Loredana, additional, Giannarelli, Diana, additional, Paris, Laura, additional, Torretta, Lorella, additional, Cavallaro, Francesca, additional, Levati, Giorgia Virginia, additional, Stefanoni, Paola, additional, Mocellin, Cristina, additional, Galli, Monica, additional, and Baldini, Luca, additional

Published
2021
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28. Additional file 1 of Covid-19 and gender: lower rate but same mortality of severe disease in women—an observational study

Author

Raimondi, Federico, Novelli, Luca, Ghirardi, Arianna, Russo, Filippo Maria, Pellegrini, Dario, Biza, Roberta, Trapasso, Roberta, Giuliani, Lisa, Anelli, Marisa, Amoroso, Mariangela, Allegri, Chiara, Imeri, Gianluca, Sanfilippo, Claudia, Comandini, Sofia, England Hila, Manesso, Leonardo, Gandini, Lucia, Mandelli, Pietro, Monti, Martina, Gori, Mauro, Senni, Michele, Lorini, Ferdinando Luca, Rizzi, Marco, Barbui, Tiziano, Paris, Laura, Rambaldi, Alessandro, Cosentini, Roberto, Guagliumi, Giulio, Cesa, Simonetta, Colledan, Michele, Sessa, Maria, Masciulli, Arianna, Gavazzi, Antonello, Buoro, Sabrina, Remuzzi, Giuseppe, Ruggenenti, Piero, Annapaola Callegaro, Gianatti, Andrea, Farina, Claudio, Bellasi, Antonio, Sironi, Sandro, Fagiuoli, Stefano, and Marco, Fabiano Di

Abstract

Additional file 1: Supplementary Definitions. Table S1. Intervals between symptoms and clinical relevant episodes in all patients and by gender. Table S2. 28-day outcomes according to gender and age.

Published
2021
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29. Additional file 2 of Covid-19 and gender: lower rate but same mortality of severe disease in women—an observational study

Author

Raimondi, Federico, Novelli, Luca, Ghirardi, Arianna, Russo, Filippo Maria, Pellegrini, Dario, Biza, Roberta, Trapasso, Roberta, Giuliani, Lisa, Anelli, Marisa, Amoroso, Mariangela, Allegri, Chiara, Imeri, Gianluca, Sanfilippo, Claudia, Comandini, Sofia, England Hila, Manesso, Leonardo, Gandini, Lucia, Mandelli, Pietro, Monti, Martina, Gori, Mauro, Senni, Michele, Lorini, Ferdinando Luca, Rizzi, Marco, Barbui, Tiziano, Paris, Laura, Rambaldi, Alessandro, Cosentini, Roberto, Guagliumi, Giulio, Cesa, Simonetta, Colledan, Michele, Sessa, Maria, Masciulli, Arianna, Gavazzi, Antonello, Buoro, Sabrina, Remuzzi, Giuseppe, Ruggenenti, Piero, Annapaola Callegaro, Gianatti, Andrea, Farina, Claudio, Bellasi, Antonio, Sironi, Sandro, Fagiuoli, Stefano, and Marco, Fabiano Di

Abstract

Additional file 2. Covid-19 Study Group.

Published
2021
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31. Predicting in-hospital mortality from Coronavirus Disease 2019: A simple validated app for clinical use

Author

Magro, Bianca, primary, Zuccaro, Valentina, additional, Novelli, Luca, additional, Zileri, Lorenzo, additional, Celsa, Ciro, additional, Raimondi, Federico, additional, Gori, Mauro, additional, Cammà, Giulia, additional, Battaglia, Salvatore, additional, Genova, Vincenzo Giuseppe, additional, Paris, Laura, additional, Tacelli, Matteo, additional, Mancarella, Francesco Antonio, additional, Enea, Marco, additional, Attanasio, Massimo, additional, Senni, Michele, additional, Di Marco, Fabiano, additional, Lorini, Luca Ferdinando, additional, Fagiuoli, Stefano, additional, Bruno, Raffaele, additional, Cammà, Calogero, additional, and Gasbarrini, Antonio, additional

Published
2021
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32. The timing of plerixafor addition to G-Csf and chemotherapy affects immunological recovery after autologous stem cell transplant in multiple myeloma

Author

Tolomelli, Giulia, primary, Mancuso, Katia, additional, Tacchetti, Paola, additional, Patriarca, Francesca, additional, Galli, Monica, additional, Pantani, Lucia, additional, Zannetti, Beatrice, additional, Motta, Maria Rosa, additional, Rizzi, Simonetta, additional, Dan, Elisa, additional, Sinigaglia, Barbara, additional, Giudice, Valeria, additional, Olmo, Andrea, additional, Arpinati, Mario, additional, Chirumbolo, Gabriella, additional, Fanin, Renato, additional, Lewis, Russell E., additional, Paris, Laura, additional, Bonifazi, Francesca, additional, Cavo, Michele, additional, Curti, Antonio, additional, and Lemoli, Roberto M., additional

Published
2019
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33. Real-Rd - Real Life Italian Experience with Lenalidomide and Low-Dose Dexamethasone (Rd) As First Line Treatment of Newly-Diagnosed Multiple Myeloma Patients Not Eligible to Stem Cell Transplantation: Outcomes and Tolerability

Author

Pompa, Alessandra, primary, Conticello, Concetta, additional, Giannarelli, Diana, additional, Pettine, Loredana, additional, Paris, Laura, additional, Tognazzi, Lucia, additional, Marcatti, Magda, additional, Antonioli, Elisabetta, additional, Fioritoni, Francesca, additional, Bonalumi, Angela, additional, Mangiacavalli, Silvia, additional, Bertazzoni, Paola, additional, Vincelli, Iolanda Donatella, additional, Derudas, Daniele, additional, Siniscalchi, Agostina, additional, Pezzatti, Sara, additional, Zambello, Renato, additional, Citro, Annalisa, additional, Belotti, Angelo, additional, Lombardo, Alessandra, additional, Vozella, Federico, additional, Sementa, Adelina, additional, Consoli, Ugo, additional, Molteni, Alfredo, additional, Frungillo, Niccolò, additional, Gentile, Massimo, additional, Buda, Gabriele, additional, Aquino, Sara, additional, Palmieri, Salvatore, additional, Bongarzoni, Velia, additional, Inzoli, Alessandro, additional, Ferla, Valeria, additional, Rossi, Francesca Gaia, additional, Leotta, Valerio, additional, Romano, Alessandra, additional, Elia, Federica, additional, Del Fabro, Vittorio, additional, Montanaro, Guido, additional, Cavallaro, Francesca, additional, Galli, Monica, additional, and Baldini, Luca, additional

Published
2019
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34. Lenalidomide-based induction and maintenance in elderly newly diagnosed multiple myeloma patients: updated results of the EMN01 randomized trial

Author

Bringhen, Sara, primary, D’Agostino, Mattia, additional, Paris, Laura, additional, Ballanti, Stelvio, additional, Pescosta, Norbert, additional, Spada, Stefano, additional, Pezzatti, Sara, additional, Grasso, Mariella, additional, Rota-Scalabrini, Delia, additional, De Rosa, Luca, additional, Pavone, Vincenzo, additional, Gazzera, Giulia, additional, Aquino, Sara, additional, Poggiu, Marco, additional, Santoro, Armando, additional, Gentile, Massimo, additional, Baldini, Luca, additional, Petrucci, Maria Teresa, additional, Tosi, Patrizia, additional, Marasca, Roberto, additional, Cellini, Claudia, additional, Palumbo, Antonio, additional, Falco, Patrizia, additional, Hájek, Roman, additional, Boccadoro, Mario, additional, and Larocca, Alessandra, additional

Published
2019
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36. First-line therapy with either bortezomib-melphalan-prednisone or lenalidomide-dexamethasone followed by lenalidomide for transplant-ineligible multiple myeloma patients: a pooled analysis of two randomized trials

Author

Larocca, Alessandra, primary, Mina, Roberto, additional, Offidani, Massimo, additional, Liberati, Anna Marina, additional, Ledda, Antonio, additional, Patriarca, Francesca, additional, Evangelista, Andrea, additional, Spada, Stefano, additional, Benevolo, Giulia, additional, Oddolo, Daniela, additional, Innao, Vanessa, additional, Cangiolosi, Clotilde, additional, Bernardini, Annalisa, additional, Musto, Pellegrino, additional, Amico, Valeria, additional, Fraticelli, Vincenzo, additional, Paris, Laura, additional, Giuliani, Nicola, additional, Falcone, Antonietta Pia, additional, Zambello, Renato, additional, De Paoli, Lorenzo, additional, Romano, Alessandra, additional, Palumbo, Antonio, additional, Montefusco, Vittorio, additional, Hájek, Roman, additional, Boccadoro, Mario, additional, and Bringhen, Sara, additional

Published
2019
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38. Introduzione

Author

PARIS, LAURA, ZANNI, NICOLETTA, GUAGNINI, ELVIO, Merluzzi, Franca, Gemo, Giorgia, L.Paris, Paris, Laura, Zanni, Nicoletta, Guagnini, Elvio, Merluzzi, Franca, and Gemo, Giorgia

Subjects
Antonio Fonda Savio, Sistema museale dell'Ateneo triestino (SmaTs), Archivio degli Scrittori e della cultura regionale, SIRPAC, Opere incorniciate
Abstract

Si tratta dell'introduzione al Lascito di Letizia e Antonio Fonda Savio conservato presso l'Archivio degli scrittori e della cultura regionale, che fa parte del Sistema museale dell'Ateneo triestino (SmaTs).Esso comprende una biblioteca di 3500 volumi, materiale archivistico-documentario e una sezione iconografica di 560 esemplari tra dipinti, stampe, disegni, vignette etc. Le opere incorniciate sono state digitalizzate e inserite nel Sistema informativo del patrimonio regionale culturale (SIRPAC) dell'Istituto per il Patrimonio Culturale del Friuli Venezia Giulia (IPAC) con sede a Villa Manin di Passariano.

Published
2015

39. Anselmo Bucci, Carlo Wostry, Giuseppe Furlani: tre interpreti della 'Finis Austriae'

Author

ZANNI, NICOLETTA, GUAGNINI, ELVIO, STORTI, ANNA, PARIS, LAURA, DE NICOLA, Francesco, ADAMO, SERGIA, Fisher, Waltraud, N.Zanni, Zanni, Nicoletta, Guagnini, Elvio, Storti, Anna, Paris, Laura, Fisher, Waltraud, DE NICOLA, Francesco, and Adamo, Sergia

Subjects
Anselmo Bucci, Carlo Wostry, Giuseppe Furlani, Finis Austriae, Archivio degli scrittori e della cultura regionale, Sistema museale dell'Ateneo triestino, Archivio degli scrittori e della cultura regionale, Anselmo Bucci, Finis Austriae, Giuseppe Furlani, Carlo Wostry, Sistema museale dell'Ateneo triestino
Abstract

Si tratta di materiale iconografico (litografie, xilografie e fotografie) del Lascito Antonio Fonda Savio conservato nell'Archivio degli Scrittori e della cultura regionale che è parte del Sistema museale dell'Ateneo triestino. I contenuti rappresentano tre diverse interpretazioni nel momento della fine dell'Impero asburgico e l'arrivo dell'Italia a Trieste e nell'Istria. Bucci interpreta lo sgomento della Finis Austriae a Pola, Wostry con pungente ironia il cambiamento camaleontico di certa classe borghese a Trieste e Furlani fotografa con un sentimento di gioia l'arrivo dell'Italia.

Published
2015

40. Guida al Lascito Antonio Fonda Savio

Author

Paris, Laura, Zanni, Nicoletta, Merluzzi, Franca, Guagnini, Elvio, and Gemo, Giorgia

Subjects
smaTs, SIRPAC, digitalizzazione opere, collezioni universitarie, Ambiente, territorio e beni culturali
Abstract

Questa pubblicazione è frutto dell’accordo tra l’Università di Trieste e l’Istituto Regionale per il Patrimonio Culturale che prevede la catalogazione in rete, attraverso il Sistema Informativo Regionale del Patrimonio Culturale (SIRPAC), di vari settori del Sistema museale di Ateneo (smaTs) comprendente collezioni universitarie di carattere scientifico e storico-artistico, per permetterne la fruizione da parte di un vasto pubblico. Il presente volume si occupa del Lascito Antonio Fonda Savio, conservato presso il Dipartimento di Studi Umanistici e costituito, oltre che da un cospicuo fondo librario e da una sezione archivistico-documentaria, da più di cinquecento opere tra dipinti, disegni, stampe, carte geografiche, perlopiù riferiti all’Istria, terra d’origine del collezionista. Di queste opere, tutte già inventariate e catalogate, oltre un centinaio sono ora oggetto di digitalizzazione.

Published
2015

41. Salvage Autologous Stem Cell Transplant for the Treatment of First Relapse Multiple Myeloma: Evidence of Its Clinical Role from a Multicenter Italian Study

Author

Mangiacavalli, Silvia, Derudas, Daniele, Belotti, Angelo, Zamagni, Elena, Paris, Laura, Pavone, Vincenzo, Mina, Roberto, Di Renzo, Nicola, Fazio, Francesca, Tarantini, Giuseppe, Pezzatti, Sara, Palumbo, Gaetano, Marcatti, Magda, Vincelli, Jolanda Donatella, Cafro, Anna Maria, Falcone, Antonietta Pia, Zambello, Renato, Conticello, Concetta, Mazza, Rita, Di Raimondo, Francesco, Pompa, Alessandra, Martino, Enrica Antonia, Morabito, Fortunato, Stefanoni, Paola, Barila, Gregorio, Farina, Francesca, Cartia, Claudio Salvatore, Casson, Andrea, Ferretti, Virginia, Fresi, Eleonora, Arcaini, Luca, Petrucci, Maria Teresa, and Gentile, Massimo

Abstract

Background:Salvage autologous stem cell transplant (sASCT) has been indicated as possible therapeutic option at first (1 st) relapse, alternative to continuous treatment with novel agent combinations in selected Multiple Myeloma (MM) patients (pts). Particularly, MM pts who are eligible for a transplant procedure at the time of relapse and who have prolonged progression free survival (PFS) after the 1 stASCT - i.e. at least 36 or 18 months, respectively, with or without Lenalidomide (Len) maintenance - are those who could benefit most from sASCT. There are limited data regarding the frequency of choice for sASCT in the current therapeutic scenario and the outcome of sASCT when incorporating novel Len-based triplets KRd (Carfilzomib-Lenalidomide-Dexamethasone) and DaraRd (Daratumumab-Lenalidomide-Dexamethasone) as induction regimens before sASCT.

Published
2023
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42. Alnuctamab (ALNUC; BMS-986349; CC-93269), a 2+1 B-Cell Maturation Antigen (BCMA) × CD3 T-Cell Engager (TCE), Administered Subcutaneously (SC) in Patients (Pts) with Relapsed/Refractory Multiple Myeloma (RRMM): Updated Results from a Phase 1 First-in-Human Clinical Study

Author

Bar, Noffar, Mateos, Maria Victoria, Ribas, Paz, Hansson, Markus, Paris, Laura, Hofmeister, Craig C., Rodriguez Otero, Paula, Bermúdez, Maria Aranzazu, Martin, Thomas, Santoro, Armando, Yee, Andrew J., Creignou, Maria, Encinas Rodriguez, Cristina, Cerchione, Claudio, De La Rubia, Javier, Oriol, Albert, Waibel, Heidi, Besemer, Britta, Thompson, Ethan, Kiesel, Brian, Chen, Jinjie, Chung, Alexander, Boss, Isaac W., Gaudy, Allison, Li, Shaoyi, Hsu, Kevin, Godwin, Colin, Burgess, Michael R., San-Miguel, Jesús, and Costa, Luciano

Abstract

Introduction :

Published
2023
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43. Impact of the Addition of Daratumumab to the Standard Bortezomib-Thalidomide-Dexamethasone Regimen on Hematopoietic Stem Cell Mobilization and Collection, Post-Transplant Engraftment and Infectious Complications: A Case-Control Multicentre Real-Life Analysis

Author

Cavallaro, Gianluca, Galli, Monica, Paris, Laura, Stefanoni, Paola, Pavoni, Chiara, Mangiacavalli, Silvia, Masoni, Valeria, Palumbo, Michele, Pompa, Alessandra, Cafro, Anna Maria, Pezzatti, Sara, Crippa, Stefano, and Rambaldi, Alessandro

Abstract

Background

Published
2023
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44. CAMMA 2: A phase I/II trial evaluating the efficacy and safety of cevostamab in patients with relapsed/refractory multiple myeloma (RRMM) who have triple-class refractory disease and have received a prior anti-B-cell maturation antigen (BCMA) agent.

Author

Kumar, Shaji, Bachier, Carlos R., Cavo, Michele, Corradini, Paolo, Delforge, Michel, Janowski, Wojt, Lesokhin, Alexander M., Mina, Roberto, Paris, Laura, Rosiñol, Laura, Quach, Hang, Goodman, Grant R., Nakamura, Rin, Samineni, Divya, Shah, Vallari, Wassner Fritsch, Elisabeth, and Berdeja, Jesus G.

Published
2023
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46. Predictors of unsustained measurable residual disease negativity in patients with multiple myeloma

Author

D’Agostino, Mattia, Bertuglia, Giuseppe, Rota-Scalabrini, Delia, Belotti, Angelo, Morè, Sonia, Corradini, Paolo, Oliva, Stefania, Ledda, Antonio, Grasso, Mariella, Pavone, Vincenzo, Ronconi, Sonia, Vincelli, Iolanda Donatella, Ballanti, Stelvio, Velluti, Cristina, Cellini, Claudia, Gozzetti, Alessandro, Palmas, Angelo D., Gamberi, Barbara, Mancuso, Katia, Paris, Laura, Zambello, Renato, Petrucci, Maria Teresa, Bruno, Benedetto, Musto, Pellegrino, and Gay, Francesca

Abstract

•Amp(1q), HRCA ≥2, high CTC levels, and a longer time to reach first MRD negativity are significant predictors of unsustained MRD negativity.•Maintenance treatment with carfilzomib-lenalidomide reduces the risk of unsustained MRD negativity vs lenalidomide alone.

Published
2023
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48. A Randomized Study of Carfilzomib-Lenalidomide-Dexamethasone Vs Carfilzomib-Cyclophosphamide-Dexamethasone Induction in Newly Diagnosed Myeloma Patients Eligible for Transplant: High Efficacy in High- and Standard-Risk Patients

Author

Gay, Francesca Maria, Rota Scalabrini, Delia, Belotti, Angelo, Galli, Monica, Zamagni, Elena, Offidani, Massimo, Oliva, Stefania, Montefusco, Vittorio, Zambello, Renato, Ledda, Antonio, Grasso, Mariella, Aquino, Sara, Esma, Fabrizio, Tosi, Patrizia, Pisani, Francesco, Annibali, Ombretta, Liberati, Anna Marina, Baraldi, Anna, Galieni, Piero, Specchia, Giorgina, Pescosta, Norbert, Mancuso, Katia, Paris, Laura, Ribolla, Rossella, Coha, Valentina, Palumbo, Antonio, Musto, Pellegrino, Cavo, Michele, and Boccadoro, Mario

Published
2017
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49. Effect of Proteasome Inhibitors and/or Immunomodulatory Drugs on the Risk of Early Death of 991 Newly Diagnosed Symptomatic Multiple Myeloma Patients: A Single Centre Retrospective Analysis

Author

Galli, Monica, Paris, Laura, Pavoni, Chiara, Delaini, Federica, and Rambaldi, Alessandro

Abstract

Introduction and aim: Several clinical trials have shown that the incorporation of novel agents (i.e., proteasome inhibitor, bortezomib and immunomodulatory drugs, thalidomide and lenalidomide) in the treatment of newly diagnosed symptomatic multiple myeloma (MM) patients improves their time to first response and survival outcomes. Nevertheless, some patients still die within 3 months (early death, ED) from starting treatment. Thus, we investigated the effect of novel agents- containing first line treatments on the risk of ED of MM patients.

Published
2017
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50. Lucie Borleteau: le vent en poupe.

Author

Tuillier à Paris, Laura

Abstract

The article presents comments by French filmmaker Lucie Borleteau who talks about her films studies and career on the occasion of the release of the DVD of her feature film "Fidelio, l'odyssée d'Alice." Topics of discussion include her first introduction to cinema, her first job as a screenplay reader, and producing and directing her first medium-length film entitled "Les Vœux."

Published
2015

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