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Your search keyword '"Popa, Laura Ioana"' showing total 17 results
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17 results on '"Popa, Laura Ioana"'

1. Network analytics for drug repurposing in COVID-19

Author

Siminea, Nicoleta, Popescu, Victor, Martin, Jose Angel Sanchez, Florea, Daniela, Gavril, Georgiana, Gheorghe, Ana-Maria, Itcus, Corina, Kanhaiya, Krishna, Pacioglu, Octavian, Popa, Laura Ioana, Trandafir, Romica, Tusa, Maria Iris, Sidoroff, Manuela, Paun, Mihaela, Czeizler, Eugen, Paun, Andrei, and Petre, Ion

Subjects
Quantitative Biology - Molecular Networks
Abstract

To better understand the potential of drug repurposing in COVID-19, we analyzed control strategies over essential host factors for SARS-CoV-2 infection. We constructed comprehensive directed protein-protein interaction networks integrating the top ranked host factors, drug target proteins, and directed protein-protein interaction data. We analyzed the networks to identify drug targets and combinations thereof that offer efficient control over the host factors. We validated our findings against clinical studies data and bioinformatics studies. Our method offers a new insight into the molecular details of the disease and into potentially new therapy targets for it. Our approach for drug repurposing is significant beyond COVID-19 and may be applied also to other diseases., Comment: 21 pages, 3 tables, 9 figures, supplementary information included at the end, 4 files as supplementary material

Published
2021

2. Temporo-spatial variations in resistance determinants and clonality of Acinetobacter baumannii and Pseudomonas aeruginosa strains from Romanian hospitals and wastewaters

Author

Gheorghe-Barbu, Irina, Barbu, Ilda Czobor, Popa, Laura Ioana, Pîrcălăbioru, Grațiela Grădișteanu, Popa, Marcela, Măruțescu, Luminița, Niță-Lazar, Mihai, Banciu, Alina, Stoica, Cătălina, Gheorghe, Ștefania, Lucaciu, Irina, Săndulescu, Oana, Paraschiv, Simona, Surleac, Marius, Talapan, Daniela, Muntean, Andrei Alexandru, Preda, Mădălina, Muntean, Mădălina-Maria, Dragomirescu, Cristiana Cerasella, Popa, Mircea Ioan, Oțelea, Dan, and Chifiriuc, Mariana Carmen

Published
2022
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4. Temporo-spatial Variations in Resistance Determinants and Clonality of Acinetobacter Baumannii and Pseudomonas Aeruginosa Strains From Romanian Hospitals and Wastewaters

Author

Gheorghe, Irina, primary, Barbu, Ilda Czobor, additional, Popa, Laura Ioana, additional, Parcalabioru, Gratiela Gradisteanu, additional, Popa, Marcela, additional, Marutescu, Luminita, additional, Nita-Lazar, Mihai, additional, Banciu, Alina, additional, Stoica, Catalina, additional, Gheorghe, Stefania, additional, Lucaciu, Irina, additional, Sandulescu, Oana, additional, Paraschiv, Simona, additional, Surleac, Marius, additional, Talapan, Daniela, additional, Muntean, Andrei Alexandru, additional, Preda, Madalina, additional, Muntean, Madalina-Maria, additional, Dragomirescu, Cristiana Cerasella, additional, Popa, Mircea Ioan, additional, Otelea, Dan, additional, and Chifiriuc, Mariana Carmen, additional

Published
2022
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5. Network analytics for drug repurposing in COVID-19

Author

Siminea, Nicoleta, primary, Popescu, Victor, additional, Sanchez Martin, Jose Angel, additional, Florea, Daniela, additional, Gavril, Georgiana, additional, Gheorghe, Ana-Maria, additional, Iţcuş, Corina, additional, Kanhaiya, Krishna, additional, Pacioglu, Octavian, additional, Popa, Laura Ioana, additional, Trandafir, Romica, additional, Tusa, Maria Iris, additional, Sidoroff, Manuela, additional, Păun, Mihaela, additional, Czeizler, Eugen, additional, Păun, Andrei, additional, and Petre, Ion, additional

Published
2021
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7. Phenotypic and genotypic virulence features of staphylococcal strains isolated from difficult-to-treat skin and soft tissue infections

Author

Preda, Mădălina, primary, Mihai, Mara Mădălina, additional, Popa, Laura Ioana, additional, Dițu, Lia-Mara, additional, Holban, Alina Maria, additional, Manolescu, Loredana Sabina Cornelia, additional, Popa, Gabriela-Loredana, additional, Muntean, Andrei-Alexandru, additional, Gheorghe, Irina, additional, Chifiriuc, Carmen Mariana, additional, and Popa, Mircea-Ioan, additional

Published
2021
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8. Multidrug Resistant Klebsiella pneumoniae ST101 Clone Survival Chain From Inpatients to Hospital Effluent After Chlorine Treatment

Author

Popa, Laura Ioana, primary, Gheorghe, Irina, additional, Barbu, Ilda Czobor, additional, Surleac, Marius, additional, Paraschiv, Simona, additional, Măruţescu, Luminiţa, additional, Popa, Marcela, additional, Pîrcălăbioru, Graţiela Grădişteanu, additional, Talapan, Daniela, additional, Niţă, Mihai, additional, Streinu-Cercel, Anca, additional, Streinu-Cercel, Adrian, additional, Oţelea, Dan, additional, and Chifiriuc, Mariana Carmen, additional

Published
2021
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9. DNA origami design and implementation

Author

Popa, Laura Ioana, Dobre, Ana-Maria, Itcus, Corina, Amarioarei, Alexandru, Paun, Andrei, Paun, Mihaela, Pop, Felician, Tusa, Iris, Minh-Kha Nguyen, Kuzyk, Anton, Czeizler, Eugen, University of Bucharest, National Institute of Research and Development for Biological Sciences, Filara Biomed Srl, Department of Neuroscience and Biomedical Engineering, Åbo Akademi University, Aalto-yliopisto, and Aalto University

Subjects
NANOSCALE, nanotechnology, nanostructure, Perdix visualization, SHAPES, DNA origami, FOLDING DNA, DNA Romanian map
Abstract

Since its introduction in the early 2000s, DNA origami had a big impact on the development of nanotechnology by gathering numerous applications. During this time, many tools were designed and used to generate arbitrary shapes capable of self-assembly which make this technique more approachable. In this paper, we have created the map of Romania at nanoscale dimensions by using a new open-source software - PERDIX. For this purpose, we used a scaffold strand with a length of 6959 nucleotides and 162 staple strands with a variable length ranging between 20 and 63 nucleotides. All the computational tools that were used in this experiment are open-source and user-friendly.

Published
2020

10. Network analytics for drug repurposing in COVID-19.

Author

Siminea, Nicoleta, Popescu, Victor, Martin, Jose Angel Sanchez, Florea, Daniela, Gavril, Georgiana, Gheorghe, Ana-Maria, Iţcuş, Corina, Kanhaiya, Krishna, Pacioglu, Octavian, Popa, Laura Ioana, Trandafir, Romica, Tusa, Maria Iris, Sidoroff, Manuela, Păun, Mihaela, Czeizler, Eugen, Păun, Andrei, and Petre, Ion

Subjects
DRUG repositioning, COVID-19, DRUG target, PROTEIN-protein interactions, SARS-CoV-2
Abstract

To better understand the potential of drug repurposing in COVID-19, we analyzed control strategies over essential host factors for SARS-CoV-2 infection. We constructed comprehensive directed protein–protein interaction (PPI) networks integrating the top-ranked host factors, the drug target proteins and directed PPI data. We analyzed the networks to identify drug targets and combinations thereof that offer efficient control over the host factors. We validated our findings against clinical studies data and bioinformatics studies. Our method offers a new insight into the molecular details of the disease and into potentially new therapy targets for it. Our approach for drug repurposing is significant beyond COVID-19 and may be applied also to other diseases. [ABSTRACT FROM AUTHOR]

Published
2022
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12. Whole genome sequencing snapshot of multi-drug resistant Klebsiella pneumoniae strains from hospitals and receiving wastewater treatment plants in Southern Romania

Author

Surleac, Marius, primary, Czobor Barbu, Ilda, additional, Paraschiv, Simona, additional, Popa, Laura Ioana, additional, Gheorghe, Irina, additional, Marutescu, Luminita, additional, Popa, Marcela, additional, Sarbu, Ionela, additional, Talapan, Daniela, additional, Nita, Mihai, additional, Iancu, Alina Viorica, additional, Arbune, Manuela, additional, Manole, Alina, additional, Nicolescu, Serban, additional, Sandulescu, Oana, additional, Streinu-Cercel, Adrian, additional, Otelea, Dan, additional, and Chifiriuc, Mariana Carmen, additional

Published
2020
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15. Snapshot of Phylogenetic Groups, Virulence, and Resistance Markers in Escherichia coli Uropathogenic Strains Isolated from Outpatients with Urinary Tract Infections in Bucharest, Romania

Author

Cristea, Violeta Corina, primary, Gheorghe, Irina, additional, Czobor Barbu, Ilda, additional, Popa, Laura Ioana, additional, Ispas, Bogdan, additional, Grigore, Georgiana Alexandra, additional, Bucatariu, Irina, additional, Popa, Gabriela Loredana, additional, Angelescu, Maria-Cristina, additional, Velican, Alexandra, additional, Marutescu, Luminita, additional, Popa, Marcela, additional, Chifiriuc, Mariana Carmen, additional, and Popa, Ioan Mircea, additional

Published
2019
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17. MOBILE GENETIC ELEMENTS INVOLVED IN THE HORIZONTAL TRANSFER OF ANTIBIOTIC RESISTANCE GENES.

Author

Popa, Laura Ioana, Barbu, Ilda Czobor, and Chifiriuc, Mariana Carmen

Subjects
*MOBILE genetic elements, *DRUG resistance in bacteria, *HORIZONTAL gene transfer, *MULTIDRUG resistance, *BACTERIAL cells
Abstract

Introduction: Antibiotics are one of the greatest discoveries of the 20th century, but this came with the great responsibility of maintaining their efficacy. Antibiotic resistance (AR) was noticed as early as the first years of the antibiotic era, the matter becoming increasingly worrying nowadays when one of the biggest threats to the global health system is the perspective of a post-antibiotic era. AR is spreading alarmingly due to the transfer of antibiotic resistance genes (ARGs) through horizontal gene transfer, especially under the selective pressure exhibited by the extensive or faulty use of antibiotics. Objectives: In this review, we discuss the mobile genetic elements (MGE) involved in horizontal gene transfer of ARGs and highlight their key role contribution to the dynamics of antibiotic resistance. Methods: A literature survey of the papers indexed in PubMed has been performed, using as key words antibiotic resistance + horizontal gene transfer, antibiotic resistance + mobile genetic elements, horizontal gene transfer + mobile genetic elements. Results: In the presence of antibiotics, MGEs have an increased likelihood to be maintained in the bacterial cells, acquire new ARGs and replicate, leading to a complex resistome and the emergence of multidrug resistance (MDR) phenotypes. Conclusions: Horizontal gene transfer of antibiotic resistance genes is far from being fully understood and majorly affects the global health system. MGEs play a decisive role in the emergence of antibiotic resistance, therefore, the mobile genetic elements must be thoroughly studied and regarded as potential targets for new antibiotic compounds. [ABSTRACT FROM AUTHOR]

Published
2018

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