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283 results on '"Ramsay, S."'

1. The MICADO first light imager for the ELT: overview and current Status

Author

Sturm, E., Davies, R., Alves, J., Clénet, Y., Kotilainen, J., Monna, A., Nicklas, H., Pott, J. -U., Tolstoy, E., Vulcani, B., Achren, J., Annadevara, S., Anwand-Heerwart, H., Arcidiacono, C., Barboza, S., Barl, L., Baudoz, P., Bender, R., Bezawada, N., Biondi, F., Bizenberger, P., Blin, A., Boné, A., Bonifacio, P., Borgo, B., Born, J. van den, Buey, T., Cao, Y., Chapron, F., Chauvin, G., Chemla, F., Cloiseau, K., Cohen, M., Collin, C., Czoske, O., Dette, J. -O., Deysenroth, M., Dijkstra, E., Dreizler, S., Dupuis, O., van Egmond, G., Eisenhauer, F., Elswijk, E., Emslander, A., Fabricius, M., Fasola, G., Ferreira, F., Schreiber, N. M. Förster, Fontana, A., Gaudemard, J., Gautherot, N., Gendron, E., Gennet, C., Genzel, R., Ghouchou, L., Gillessen, S., Gratadour, D., Grazian, A., Grupp, F., Guieu, S., Gullieuszik, M., de Haan, M., Hartke, J., Hartl, M., Haussmann, F., Helin, T., Hess, H. -J., Hofferbert, R., Huber, H., Huby, E., Huet, J. -M., Ives, D., Janssen, A., Jaufmann, P., Jilg, T., Jodlbauer, D., Jost, J., Kausch, W., Kellermann, H., Kerber, F., Kravcar, H., Kravchenko, K., Kulcsár, C., Kunkarayakti, H., Kunst, P., Kwast, S., Lang, F., Lange, J., Lapeyrere, V., Ruyet, B. Le, Leschinski, K., Locatelli, H., Massari, D., Mattila, S., Mei, S., Merlin, F., Meyer, E., Michel, C., Mohr, L., Montargès, M., Müller, F., Münch, N., Navarro, R., Neumann, U., Neumayer, N., Neumeier, L., Pedichini, F., Pflüger, A., Piazzesi, R., Pinard, L., Porras, J., Portaluri, E., Przybilla, N., Rabien, S., Raffard, J., Raggazoni, R., Ramlau, R., Ramos, J., Ramsay, S., Raynaud, H. -F., Rhode, P., Richter, A., Rix, H. -W., Rodenhuis, M., Rohloff, R. -R., Romp, R., Rousselot, P., Sabha, N., Sassolas, B., Schlichter, J., Schuil, M., Schweitzer, M., Seemann, U., Sevin, A., Simioni, M., Spallek, L., Sönmez, A., Suuronen, J., Taburet, S., Thomas, J., Tisserand, E., Vaccari, P., Valenti, E., Kleijn, G. Verdoes, Verdugo, M., Vidal, F., Wagner, R., Wegner, M., van Winden, D., Witschel, J., Zanella, A., Zeilinger, W., Ziegleder, J., and Ziegler, B.

Subjects
Astrophysics - Instrumentation and Methods for Astrophysics
Abstract

MICADO is a first light instrument for the Extremely Large Telescope (ELT), set to start operating later this decade. It will provide diffraction limited imaging, astrometry, high contrast imaging, and long slit spectroscopy at near-infrared wavelengths. During the initial phase operations, adaptive optics (AO) correction will be provided by its own natural guide star wavefront sensor. In its final configuration, that AO system will be retained and complemented by the laser guide star multi-conjugate adaptive optics module MORFEO (formerly known as MAORY). Among many other things, MICADO will study exoplanets, distant galaxies and stars, and investigate black holes, such as Sagittarius A* at the centre of the Milky Way. After their final design phase, most components of MICADO have moved on to the manufacturing and assembly phase. Here we summarize the final design of the instrument and provide an overview about its current manufacturing status and the timeline. Some lessons learned from the final design review process will be presented in order to help future instrumentation projects to cope with the challenges arising from the substantial differences between projects for 8-10m class telescopes (e.g. ESO-VLT) and the next generation Extremely Large Telescopes (e.g. ESO-ELT). Finally, the expected performance will be discussed in the context of the current landscape of astronomical observatories and instruments. For instance, MICADO will have similar sensitivity as the James Webb Space Telescope (JWST), but with six times the spatial resolution., Comment: Proceedings of the SPIE, Volume 13096, id. 1309611 11 pp. (2024)

Published
2024
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3. NIR jets from a clustered region of massive star formation: Morphology and composition in the IRAS 18264-1152 region

Author

Silva, A. R. Costa, Fedriani, R., Tan, J. C., Garatti, A. Caratti o, Ramsay, S., Rosero, V., Cosentino, G., Gorai, P., and Leurini, S.

Subjects
Astrophysics - Solar and Stellar Astrophysics, Astrophysics - Astrophysics of Galaxies
Abstract

Massive stars form deeply embedded in their parental clouds, making it challenging to directly observe these stars and their immediate environments. It is known that accretion and ejection processes are intrinsically related, thus observing massive protostellar outflows can provide crucial information about the processes governing massive star formation close to the central engine. We aim to probe the IRAS 18264-1152 (G19.88-0.53) high-mass star-forming complex in the near infrared (NIR) through its molecular hydrogen (H2) jets to analyse the morphology and composition of the line emitting regions and to compare with other outflow tracers. We observed the H2 NIR jets via K-band (1.9-2.5um) observations obtained with the integral field units VLT/SINFONI and VLT/KMOS. SINFONI provides the highest NIR angular resolution achieved so far for the central region (~0.2''). We compared the geometry of the NIR outflows with that of the associated molecular outflow probed by CO (2-1) emission mapped with SMA. We identify nine point sources. Four of these display a rising continuum in the K-band and are BrG emitters, revealing that they are young, potentially jet-driving sources. The spectro-imaging analysis focusses on the H2 jets, for which we derived visual extinction, temperature, column density, area, and mass. The intensity, velocity, and excitation maps based on H2 emission strongly support the existence of a protostellar cluster, with at least two (and up to four) different large-scale outflows. The literature is in agreement with the outflow morphology found here. We derived a stellar density of ~4000 stars pc^-3. Our study reveals the presence of several outflows driven by young sources from a forming cluster of young, massive stars. The derived stellar number density together with the geometry of the outflows suggest that stars can form in a relatively ordered manner in this cluster., Comment: 23 pages, 14 figures. Published in A&A. Updated to correct typos and match proofs

Published
2021
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4. Verifying Liveness Properties of ML Programs

Author

Lester, M. M., Neatherway, R. P., Ong, C. -H. L., and Ramsay, S. J.

Subjects
Computer Science - Programming Languages
Abstract

Higher-order recursion schemes are a higher-order analogue of Boolean Programs; they form a natural class of abstractions for functional programs. We present a new, efficient algorithm for checking CTL properties of the trees generated by higher-order recursion schemes, which is an extension of Kobayashi's intersection type-based model checking technique. We show that an implementation of this algorithm, THORS, performs well on a number of small examples and we demonstrate how it can be used to verify liveness properties of OCaml programs. Example properties include statements such as "all opened sockets are eventually closed" and "the lock is held until the file is closed"., Comment: Peer-reviewed extended abstract presented at 2011 ACM SIGPLAN Workshop on ML. Full technical report archived at: https://ora.ox.ac.uk/objects/uuid:bf35bab8-b395-4f85-93bd-57ca0328a1d3

Published
2020

5. Feedback from massive stars at low metallicities: MUSE observations of N44 and N180 in the Large Magellanic Cloud

Author

McLeod, A. F., Dale, J. E., Evans, C. J., Ginsburg, A., Kruijssen, J. M. D., Pellegrini, E. W., Ramsay, S. K., and Testi, L.

Subjects
Astrophysics - Astrophysics of Galaxies, Astrophysics - Solar and Stellar Astrophysics
Abstract

We present MUSE integral field data of two HII region complexes in the Large Magellanic Cloud (LMC), N44 and N180. Both regions consist of a main superbubble and a number of smaller, more compact HII regions that formed on the edge of the superbubble. For a total of 11 HII regions, we systematically analyse the radiative and mechanical feedback from the massive O-type stars on the surrounding gas. We exploit the integral field property of the data and the coverage of the HeII$\lambda$5412 line to identify and classify the feedback-driving massive stars, and from the estimated spectral types and luminosity classes we determine the stellar radiative output in terms of the ionising photon flux $Q_{0}$. We characterise the HII regions in terms of their sizes, morphologies, ionisation structure, luminosity and kinematics, and derive oxygen abundances via emission line ratios. We analyse the role of different stellar feedback mechanisms for each region by measuring the direct radiation pressure, the pressure of the ionised gas, and the pressure of the shock-heated winds. We find that stellar winds and ionised gas are the main drivers of HII region expansion in our sample, while the direct radiation pressure is up to three orders of magnitude lower than the other terms. We relate the total pressure to the star formation rate per unit area, $\Sigma_{SFR}$, for each region and find that stellar feedback has a negative effect on star formation, and sets an upper limit to $\Sigma_{SFR}$ as a function of increasing pressure., Comment: Accepted for publication in MNRAS, 27 pages, 21 figures

Published
2018
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6. Discovery of two embedded massive YSOs and an outflow in IRAS 18144-1723

Author

Varricatt, W. P., Wouterloot, J. G. A., Ramsay, S. K., and Davis, C. J.

Subjects
Astrophysics - Solar and Stellar Astrophysics, Astrophysics - Astrophysics of Galaxies
Abstract

Massive stars are rarely seen to form in isolation. It has been proposed that association with companions or clusters in the formative stages is vital to their mass accumulation. In this paper we study IRAS~18144-1723, a massive young stellar object (YSO) which had been perceived in early studies as a single source. In the CO(3-2) line, we detect an outflow aligned well with the outflow seen in H$_2$ in this region. We show that there are at least two YSOs here, and that the outflow is most likely to be from a deeply embedded source detected in our infrared imaging. Using multi-wavelength observations, we study the outflow and the embedded source and derive their properties. We conclude that IRAS~18144 hosts an isolated cloud, in which at least two massive YSOs are being born. From our sub-mm observations, we derive the mass of the cloud and the core hosting the YSOs., Comment: 14 pages, 14 figures, accepted for publication in the Monthly Notices of the Royal Astronomical Society

Published
2018
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8. CRIRES-POP: a library of high resolution spectra from 1 to 5 microns II. Data reduction and the spectrum of the K giant 10 Leo

Author

Nicholls, C. P., Lebzelter, T., Smette, A., Wolff, B., Hartman, H., Käufl, H. -U., Przybilla, N., Ramsay, S., Uttenthaler, S., Wahlgren, G. M., Bagnulo, S., Hussain, G. A. J., Nieva, M. -F., Seeman, U., and Seifahrt, A.

Subjects
Astrophysics - Solar and Stellar Astrophysics
Abstract

Context. High resolution stellar spectral atlases are valuable resources to astronomy. They are rare in the $1 - 5\,\mu$m region for historical reasons, but once available, high resolution atlases in this part of the spectrum will aid the study of a wide range of astrophysical phenomena. Aims. The aim of the CRIRES-POP project is to produce a high resolution near-infrared spectral library of stars across the H-R diagram. The aim of this paper is to present the fully reduced spectrum of the K giant 10 Leo that will form the basis of the first atlas within the CRIRES-POP library, to provide a full description of the data reduction processes involved, and to provide an update on the CRIRES-POP project. Methods. All CRIRES-POP targets were observed with almost 200 different observational settings of CRIRES on the ESO Very Large Telescope, resulting in a basically complete coverage of its spectral range as accessible from the ground. We reduced the spectra of 10 Leo with the CRIRES pipeline, corrected the wavelength solution and removed telluric absorption with Molecfit, then resampled the spectra to a common wavelength scale, shifted them to rest wavelengths, flux normalised, and median combined them into one final data product. Results. We present the fully reduced, high resolution, near-infrared spectrum of 10 Leo. This is also the first complete spectrum from the CRIRES instrument. The spectrum is available online. Conclusions. The first CRIRES-POP spectrum has exceeded our quality expectations and will form the centre of a state-of-the-art stellar atlas. This first CRIRES-POP atlas will soon be available, and further atlases will follow. All CRIRES-POP data products will be freely and publicly available online., Comment: 12 pages, 12 figures, accepted to A&A

Published
2016
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9. Connecting the dots: a correlation between ionising radiation and cloud mass-loss rate traced by optical integral field spectroscopy

Author

McLeod, A. F., Gritschneder, M., Dale, J. E., Ginsburg, A., Klaassen, P. D., Mottram, J. C., Preibisch, T., Ramsay, S., Reiter, M., and Testi, L.

Subjects
Astrophysics - Astrophysics of Galaxies, Astrophysics - Solar and Stellar Astrophysics
Abstract

We present an analysis of the effect of feedback from O- and B-type stars with data from the integral field spectrograph MUSE mounted on the Very Large Telescope of pillar-like structures in the Carina Nebular Complex, one of the most massive star-forming regions in the Galaxy. For the observed pillars, we compute gas electron densities and temperatures maps, produce integrated line and velocity maps of the ionised gas, study the ionisation fronts at the pillar tips, analyse the properties of the single regions, and detect two ionised jets originating from two distinct pillar tips. For each pillar tip we determine the incident ionising photon flux $Q_\mathrm{0,pil}$ originating from the nearby massive O- and B-type stars and compute the mass-loss rate $\dot{M}$ of the pillar tips due to photo-evaporation caused by the incident ionising radiation. We combine the results of the Carina data set with archival MUSE data of a pillar in NGC 3603 and with previously published MUSE data of the Pillars of Creation in M16, and with a total of 10 analysed pillars, find tight correlations between the ionising photon flux and the electron density, the electron density and the distance from the ionising sources, and the ionising photon flux and the mass-loss rate. The combined MUSE data sets of pillars in regions with different physical conditions and stellar content therefore yield an empirical quantification of the feedback effects of ionising radiation. In agreement with models, we find that $\dot{M}\propto Q_\mathrm{0,pil}^{1/2}$., Comment: Accepted for publication in MNRAS, 36 pages, 30 figures

Published
2016
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10. MICADO: first light imager for the E-ELT

Author

Davies, R., Schubert, J., Hartl, M., Alves, J., Clénet, Y., Lang-Bardl, F., Nicklas, H., Pott, J. -U., Ragazzoni, R., Tolstoy, E., Agocs, T., Anwand-Heerwart, H., Barboza, S., Baudoz, P., Bender, R., Bizenberger, P., Boccaletti, A., Boland, W., Bonifacio, P., Briegel, F., Buey, T., Chapron, F., Cohen, M., Czoske, O., Dreizler, S., Falomo, R., Feautrier, P., Schreiber, N. Förster, Gendron, E., Genzel, R., Glück, M., Gratadour, D., Greimel, R., Grupp, F., Häuser, M., Haug, M., Hennawi, J., Hess, H. -J., Hörmann, V., Hofferbert, R., Hopp, U., Hubert, Z., Ives, D., Kausch, W., Kerber, F., Kravcar, H., Kuijken, K., Leitzinger, M., Leschinski, K., Massari, D., Mei, S., Merlin, F., Mohr, L., Monna, A., Müller, F., Navarro, R., Plattner, M., Przybilla, N., Ramlau, R., Ramsay, S., Ratzka, T., Rhode, P., Richter, J., Rix, H. -W., Rodeghiero, G., Rohloff, R. -R., Rousset, G., Ruddenklau, R., Schaffenroth, V., Schlichter, J., Sevin, A., Stuik, R., Sturm, E., Thomas, J., Tromp, N., Turatto, M., Verdoes-Kleijn, G., Vidal, F., Wagner, R., Wegner, M., Zeilinger, W., Ziegler, B., and Zins, G.

Subjects
Astrophysics - Instrumentation and Methods for Astrophysics
Abstract

MICADO will equip the E-ELT with a first light capability for diffraction limited imaging at near-infrared wavelengths. The instrument's observing modes focus on various flavours of imaging, including astrometric, high contrast, and time resolved. There is also a single object spectroscopic mode optimised for wavelength coverage at moderately high resolution. This contribution provides an overview of the key functionality of the instrument, outlining the scientific rationale for its observing modes. The interface between MICADO and the adaptive optics system MAORY that feeds it is summarised. The design of the instrument is discussed, focussing on the optics and mechanisms inside the cryostat, together with a brief overview of the other key sub-systems., Comment: to appear in Ground-based and Airborne Instrumentation for Astronomy VI, eds. Evans C., Simard L., Takami H., Proc. SPIE vol. 9908 id 73; 2016

Published
2016
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11. A nebular analysis of the central Orion Nebula with MUSE

Author

Leod, A. F. Mc, Weilbacher, P. M., Ginsburg, A., Dale, J. E., Ramsay, S., and Testi, L.

Subjects
Astrophysics - Astrophysics of Galaxies, Astrophysics - Solar and Stellar Astrophysics
Abstract

A nebular analysis of the central Orion Nebula and its main structures is presented. We exploit MUSE integral field observations in the wavelength range 4595-9366 \r{A} to produce the first O, S and N ionic and total abundance maps of a region spanning 6' x 5' with a spatial resolution of 0.2". We use the S$_{23}$ ( = ([SII]$\lambda$6717,31+[SIII]$\lambda$9068)/H$\beta$) parameter, together with [OII]/[OIII] as an indicator of the degree of ionisation, to distinguish between the various small-scale structures. The only Orion Bullet covered by MUSE is HH 201, which shows a double component in the [FeII]$\lambda$8617 line throughout indicating an expansion, and we discuss a scenario in which this object is undergoing a disruptive event. We separate the proplyds located south of the Bright Bar into four categories depending on their S$_{23}$ values, propose the utility of the S$_{23}$ parameter as an indicator of the shock-contribution to the excitation of line-emitting atoms, and show that the MUSE data is able to identify the proplyds associated with disks and microjets. We compute the second order structure function for the H$\alpha$, [OIII]$\lambda$5007, [SII]$\lambda$6731 and [OI]$\lambda$6300 emission lines to analyse the turbulent velocity field of the region covered with MUSE. We find that the spectral and spatial resolution of MUSE is not able to faithfully reproduce the structure functions of previous works., Comment: 34 pages, 31 figures, published in MNRAS, added missing citation

Published
2015

12. Glossary of terms used in chemoinformatics of natural products: advanced concepts and applications

Author

Ntie-Kang, Fidele, primary, Olğaç, Abdurrahman, additional, Simoben, Conrad V., additional, Najjar, Abdulkarim, additional, Akone, Sergi Herve, additional, Paul, Lucas, additional, Kamdem, Ramsay S. T., additional, Madariaga-Mazón, Abraham, additional, Mudogo, Celestin N., additional, Eni, Donatus B., additional, Bekono, Boris D., additional, Baldo, Fatima, additional, Robaa, Dina, additional, Shadrack, Daniel M., additional, Hernández-Alvarado, Ricardo B., additional, Martinez-Mayorga, Karina, additional, Medina-Franco, José L., additional, Svozil, Daniel, additional, and Sippl, Wolfgang, additional

Published
2021
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14. The Pillars of Creation revisited with MUSE: gas kinematics and high-mass stellar feedback traced by optical spectroscopy

Author

Leod, A. F. Mc, Dale, J. E., Ginsburg, A., Ercolano, B., Gritschneder, M., Ramsay, S., and Testi, L.

Subjects
Astrophysics - Solar and Stellar Astrophysics
Abstract

Integral field unit (IFU) data of the iconic Pillars of Creation in M16 are presented. The ionisation structure of the pillars was studied in great detail over almost the entire visible wavelength range, and maps of the relevant physical parameters, e.g. extinction, electron density, electron temperature, line-of-sight velocity of the ionised and neutral gas are shown. In agreement with previous authors, we find that the pillar tips are being ionised and photo-evaporated by the massive members of the nearby cluster NGC 6611. They display a stratified ionisation structure where the emission lines peak in a descending order according to their ionisation energies. The IFU data allowed us to analyse the kinematics of the photo-evaporative flow in terms of the stratified ionisation structure, and we find that, in agreement with simulations, the photo-evaporative flow is traced by a blueshift in the position-velocity profile. The gas kinematics and ionisation structure have allowed us to produce a sketch of the 3D geometry of the Pillars, positioning the pillars with respect to the ionising cluster stars. We use a novel method to detect a previously unknown bipolar outflow at the tip of the middle pillar and suggest that it has an embedded protostar as its driving source. Furthermore we identify a candidate outflow in the leftmost pillar. With the derived physical parameters and ionic abundances, we estimate a mass loss rate due to the photo-evaporative flow of 70 M$_{\odot}$ Myr$^{-1}$ which yields an expected lifetime of approximately 3 Myr., Comment: 25 pages, 21 figures, appendix 10 pages and 10 figures, MNRAS in press

Published
2015
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15. DEQ: Equivalence Checker for Deterministic Register Automata

Author

Murawski, A. S., Ramsay, S. J., Tzevelekos, N., Goos, Gerhard, Founding Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Woeginger, Gerhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Chen, Yu-Fang, editor, Cheng, Chih-Hong, editor, and Esparza, Javier, editor

Published
2019
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19. Figure S3 from A Phase I Study of Pegylated Arginine Deiminase (Pegargiminase), Cisplatin, and Pemetrexed in Argininosuccinate Synthetase 1-Deficient Recurrent High-grade Glioma

Author

Hall, Peter E., primary, Lewis, Rachel, primary, Syed, Nelofer, primary, Shaffer, Richard, primary, Evanson, Jane, primary, Ellis, Stephen, primary, Williams, Matthew, primary, Feng, Xiaoxing, primary, Johnston, Amanda, primary, Thomson, Jim A., primary, Harris, Fiona P., primary, Jena, Raj, primary, Matys, Tomasz, primary, Jefferies, Sarah, primary, Smith, Kate, primary, Wu, Bor-Wen, primary, Bomalaski, John S., primary, Crook, Timothy, primary, O'Neill, Kevin, primary, Paraskevopoulos, Dimitris, primary, Khadeir, Ramsay S., primary, Sheaff, Michael, primary, Pacey, Simon, primary, Plowman, Piers N., primary, and Szlosarek, Peter W., primary

Published
2023
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21. Figure S3 from A Phase I Study of Pegylated Arginine Deiminase (Pegargiminase), Cisplatin, and Pemetrexed in Argininosuccinate Synthetase 1-Deficient Recurrent High-grade Glioma

Author

Peter W. Szlosarek, Piers N. Plowman, Simon Pacey, Michael Sheaff, Ramsay S. Khadeir, Dimitris Paraskevopoulos, Kevin O'Neill, Timothy Crook, John S. Bomalaski, Bor-Wen Wu, Kate Smith, Sarah Jefferies, Tomasz Matys, Raj Jena, Fiona P. Harris, Jim A. Thomson, Amanda Johnston, Xiaoxing Feng, Matthew Williams, Stephen Ellis, Jane Evanson, Richard Shaffer, Nelofer Syed, Rachel Lewis, and Peter E. Hall

Abstract

Effects of ADI-PEG20 on the folate pathway

Published
2023

22. Data from A Phase I Study of Pegylated Arginine Deiminase (Pegargiminase), Cisplatin, and Pemetrexed in Argininosuccinate Synthetase 1-Deficient Recurrent High-grade Glioma

Author

Peter W. Szlosarek, Piers N. Plowman, Simon Pacey, Michael Sheaff, Ramsay S. Khadeir, Dimitris Paraskevopoulos, Kevin O'Neill, Timothy Crook, John S. Bomalaski, Bor-Wen Wu, Kate Smith, Sarah Jefferies, Tomasz Matys, Raj Jena, Fiona P. Harris, Jim A. Thomson, Amanda Johnston, Xiaoxing Feng, Matthew Williams, Stephen Ellis, Jane Evanson, Richard Shaffer, Nelofer Syed, Rachel Lewis, and Peter E. Hall

Abstract

Purpose:Patients with recurrent high-grade gliomas (HGG) are usually managed with alkylating chemotherapy ± bevacizumab. However, prognosis remains very poor. Preclinically, we showed that HGGs are a target for arginine depletion with pegargiminase (ADI-PEG20) due to epimutations of argininosuccinate synthetase (ASS1) and/or argininosuccinate lyase (ASL). Moreover, ADI-PEG20 disrupts pyrimidine pools in ASS1-deficient HGGs, thereby impacting sensitivity to the antifolate, pemetrexed.Patients and Methods:We expanded a phase I trial of ADI-PEG20 with pemetrexed and cisplatin (ADIPEMCIS) to patients with ASS1-deficient recurrent HGGs (NCT02029690). Patients were enrolled (01/16–06/17) to receive weekly ADI-PEG20 36 mg/m2 intramuscularly plus pemetrexed 500 mg/m2 and cisplatin 75 mg/m2 intravenously once every 3 weeks for up to 6 cycles. Patients with disease control were allowed ADI-PEG20 maintenance. The primary endpoints were safety, tolerability, and preliminary estimates of efficacy.Results:Ten ASS1-deficient heavily pretreated patients were treated with ADIPEMCIS therapy. Treatment was well tolerated with the majority of adverse events being Common Terminology Criteria for Adverse Events v4.03 grade 1-2. The best overall response was stable disease in 8 patients (80%). Plasma arginine was suppressed significantly below baseline with a reciprocal increase in citrulline during the sampling period. The anti–ADI-PEG20 antibody titer rose during the first 4 weeks of treatment before reaching a plateau. Median progression-free survival (PFS) was 5.2 months (95% confidence interval (CI), 2.5–20.8) and overall survival was 6.3 months (95% CI, 1.8–9.7).Conclusions:In this recurrent HGG study, ADIPEMCIS was well tolerated and compares favorably to historical controls. Additional trials of ADI-PEG20 in HGG are planned.

Published
2023

23. Painful Retiform Purpura in a Peritoneal Dialysis Patient.

Author

Jabbour, Austin J., Mannava, Kathleen, Farah, Ramsay S., and Farah, Joyce

Subjects
CALCIPHYLAXIS, HEMODIALYSIS patients, PERITONEAL dialysis, POLYARTERITIS nodosa, DISEASE risk factors, BLOOD diseases, MEDICAL communication
Abstract

The article discusses a case study of a 72-year-old woman undergoing peritoneal dialysis who presented with confusion and lethargy, accompanied by retiform purpura and elevated creatinine levels, ultimately diagnosed with calcific uremic arteriolopathy. Topics include the clinical presentation and management of this rare, life-threatening syndrome characterized by vascular calcification, highlighting the challenges in its treatment and the high mortality associated with the disease.

Published
2024
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27. γ-Glutamyl-β-phenylethylamine, a novel α-glucosidase and α-amylase inhibitory compound from Termitomyces robustus, an edible Nigerian mushroom

Author

Omonike O. Ogbole, Clarice Noleto-Dias, Ramsay S. T. Kamdem, Toluwanimi E. Akinleye, Abraham Nkumah, Jane L. Ward, and Michael H. Beale

Subjects
A-glycosidase, Antidiabetic, Organic Chemistry, Plant Science, Termitomyces robustus, γ-Glutamyl-β-phenylethylamine, Biochemistry, A-amylase, Analytical Chemistry
Abstract

Termitomyces species are known edible mushrooms in Nigeria, believed to have exceptional culinary and nutraceutical properties. Methanol extract from fruiting bodies of Termitomyces robustus was evaluated for antidiabetic activity using in vitro α-amylase and α-glucosidase assays. The isolation and structural elucidation of metabolites from the T. robustus extract afforded five compounds including a new natural product γ-glutamyl-β-phenylethylamine 3 and four known phenyl derivatives: tryptophan 1, 4-hydroxyphenylacetic acid 2, 4-hydroxyphenylpropionic acid 4, and phenyllactic acid 5. Structures were elucidated from analyses of spectroscopic data (1 D and 2 D NMR, HRESIMS) and all isolated compounds were tested for α-amylase and α-glycosidase inhibitory activity. The in vitro assay established crude extract to possess α- amylase and α-glucosidase inhibition with IC50 of 78.05 µg/mL and 86.10 µg/mL, respectively. The isolated compounds compared favourably with the standard drug, acarbose with IC50 ranging from 6.18-15.08 µg/mL and 18.28-44.63 µg/mL for α-amylase and glucosidase, respectively.

Published
2021

32. Worldwide Variation in the Use of Nuclear Cardiology Camera Technology, Reconstruction Software, and Imaging Protocols

Author

Hirschfeld, Cole B., primary, Mercuri, Mathew, additional, Pascual, Thomas N.B., additional, Karthikeyan, Ganesan, additional, Vitola, João V., additional, Mahmarian, John J., additional, Better, Nathan, additional, Bouyoucef, Salah E., additional, Hee-Seung Bom, Henry, additional, Lele, Vikram, additional, Magboo, V. Peter C., additional, Alexánderson, Erick, additional, Allam, Adel H., additional, Al-Mallah, Mouaz H., additional, Dorbala, Sharmila, additional, Flotats, Albert, additional, Jerome, Scott, additional, Kaufmann, Philipp A., additional, Luxenburg, Osnat, additional, Shaw, Leslee J., additional, Underwood, S. Richard, additional, Rehani, Madan M., additional, Paez, Diana, additional, Dondi, Maurizio, additional, Einstein, Andrew J., additional, Einstein, A.J., additional, Pascual, T.N.B., additional, Paez, D., additional, Dondi, M., additional, Better, N., additional, Bouyoucef, S.E., additional, Karthikeyan, G., additional, Kashyap, R., additional, Lele, V., additional, Magboo, V.P.C., additional, Mahmarian, J.J., additional, Meeks, J.B., additional, Mercuri, M., additional, Mut, F., additional, Rehani, M.M., additional, Vitola, J.V., additional, Alexanderson, E., additional, Allam, A., additional, Al-Mallah, M.H., additional, Bom, H., additional, Flotats, A., additional, Jerome, S., additional, Kaufmann, P.A., additional, Luxenburg, O., additional, Mahmarian, J., additional, Shaw, L.J., additional, Underwood, S.R., additional, Vitola, J., additional, Amouri, W., additional, Essabbah, H., additional, Gassama, S.S., additional, Makhdomi, K.B., additional, El Mustapha, G.I.E., additional, El Ouchdi, N., additional, Qaïs, N., additional, Soni, N., additional, Vangu, W., additional, Abazid, R.M., additional, Adams, B., additional, Agarwal, V., additional, Alfeeli, M.A., additional, Alnafisi, N., additional, Bernabe, L., additional, Bural, G.G., additional, Chaiwatanarat, T., additional, Chandraguptha, J.M., additional, Cheon, G.J., additional, Cho, I., additional, Dogan, A.S., additional, Eftekhari, M., additional, Frenkel, A., additional, Garty, I., additional, George, S., additional, Geramifar, P., additional, Golan, H., additional, Habib, S., additional, Hussain, R., additional, Im, H., additional, Jeon, H.-J., additional, Kalawat, T., additional, Kang, W.J., additional, Keng, F., additional, Klaipetch, A., additional, Kumar, P.G., additional, Lee, J., additional, Lee, W.W., additional, Lim, I., additional, Macaisa, C.M.M., additional, Malhotra, G., additional, Mittal, B.R., additional, Mohammad, M.H., additional, Mohan, P., additional, Mulyanto, I.D., additional, Nariman, D., additional, Nayak, U.N., additional, Niaz, K., additional, Nikolov, G., additional, Obaldo, J.M., additional, Ozturk, E., additional, Park, J.M., additional, Park, S., additional, Patel, C.D., additional, Phuong, H.K., additional, Quinon, A.P., additional, Rajini, T.R., additional, Saengsuda, Y., additional, Santiago, J., additional, Sayman, H.B., additional, Shinto, A.S., additional, Sivasubramaniyan, V., additional, Son, M.H., additional, Sudhakar, P., additional, Syed, G.M.S., additional, Tamaki, N., additional, Thamnirat, K., additional, Thientunyakit, T., additional, Thongmak, S., additional, Velasco, D.N., additional, Verma, A., additional, Vutrapongwatana, U., additional, Wang, Y., additional, Won, K.S., additional, Yao, Z., additional, Yingsa-nga, T., additional, Yudistiro, R., additional, Yue, K.T., additional, Zafrir, N., additional, Adrian, S.C., additional, Agostini, D., additional, Aguadé, S., additional, Armitage, G., additional, Backlund, M., additional, Backman, M., additional, Baker, M., additional, Balducci, M.T., additional, Bavelaar, C., additional, Berovic, M., additional, Bertagna, F., additional, Beuchel, R., additional, Biggi, A., additional, Bisi, G., additional, Bonini, R., additional, Bradley, A., additional, Brudin, L., additional, Bruno, I., additional, Busnardo, E., additional, Casoni, R., additional, Choudhri, A., additional, Cittanti, C., additional, Clauss, R., additional, Costa, D.C., additional, Costa, M., additional, Dixon, K., additional, Dziuk, M., additional, Egelic, N., additional, Eriksson, I., additional, Fagioli, G., additional, de Faria, D.B., additional, Florimonte, L., additional, Francini, A., additional, French, M., additional, Gallagher, E., additional, Garai, I., additional, Geatti, O., additional, Genovesi, D., additional, Gianolli, L., additional, Gimelli, A., additional, Giudice, E. del, additional, Halliwell, S., additional, Hansson, M.J., additional, Harrison, C., additional, Homans, F., additional, Horton, F., additional, Jędrzejuk, D., additional, Jogi, J., additional, Johansen, A., additional, Johansson, H., additional, Kalnina, M., additional, Kaminek, M., additional, Kiss, A., additional, Kobylecka, M., additional, Kostkiewicz, M., additional, Kropp, J., additional, Kullenberg, R., additional, Lahoutte, T., additional, Lang, O., additional, Larsson, Y.H., additional, Lázár, M., additional, Leccisotti, L., additional, Leners, N., additional, Lindner, O., additional, Lipp, R.W., additional, Maenhout, A., additional, Maffioli, L., additional, Marcassa, C., additional, Martins, B., additional, Marzullo, P., additional, Medolago, G., additional, Mendiguchía, C.G., additional, Mirzaei, S., additional, Mori, M., additional, Nardi, B., additional, Nazarenko, S., additional, Nikoletic, K., additional, Oleksa, R., additional, Parviainen, T., additional, Patrina, J., additional, Peace, R., additional, Pirich, C., additional, Piwowarska-Bilska, H., additional, Popa, S., additional, Prakash, V., additional, Pubul, V., additional, Puklavec, L., additional, Rac, S., additional, Ratniece, M., additional, Rogan, S.A., additional, Romeo, A., additional, Rossi, M., additional, Ruiz, D., additional, Sabharwal, N., additional, Salobir, B.G., additional, Santos, A.I., additional, Saranovic, S., additional, Sarkozi, A., additional, Schneider, R.P., additional, Sciagra, R., additional, Scotti, S., additional, Servini, Z., additional, Setti, L.R., additional, Starck, S.-Å., additional, Vajauskas, D., additional, Veselý, J., additional, Vieni, A., additional, Vignati, A., additional, Vito, I.M., additional, Weiss, K., additional, Wild, D., additional, Zdraveska-Kochovska, M., additional, Agüro, R.N., additional, Alvarado, N., additional, Barral, C.M., additional, Beretta, M., additional, Berrocal, I., additional, Cuellar, J.F. Batista, additional, Cabral Chang, T.-M., additional, Cabrera Rodríguez, L.O., additional, Canessa, J., additional, Castro Mora, G., additional, Claudia, A.C., additional, Clavelo, G.F., additional, Júnior, A.F. Cruz, additional, Faccio, F.F., additional, Fernández, K.M., additional, Garibo, J.R. Gomez, additional, Gonzalez, U., additional, González E, P., additional, Guzzo, M.A., additional, Jofre, J., additional, Kapitán, M., additional, Kempfer, G., additional, Lopez, J.L., additional, Massardo V, T., additional, Medeiros Colaco, I., additional, Mesquita, C.T., additional, Montecinos, M., additional, Neubauer, S., additional, Pabon, L.M., additional, Puente, A., additional, Rochela Vazquez, L.M., additional, Serna Macias, J.A., additional, Silva Pino, A.G., additional, Huber, F.Z. Tártari, additional, Tovar, A.P., additional, Vargas, L., additional, Wiefels, C., additional, Aljizeeri, A., additional, Alvarez, R.J., additional, Barger, D., additional, Beardwood, W., additional, Behrens, J., additional, Brann, L., additional, Brown, D., additional, Carr, H., additional, Churchwell, K., additional, Comingore, G.A., additional, Corbett, J., additional, Costello, M., additional, Cruz, F., additional, Depinet, T., additional, Dorbala, S., additional, Earles, M., additional, Esteves, F.P., additional, Etherton, E., additional, Fanning, R.J., additional, Fornace, J., additional, Franks, L., additional, Gewirtz, H., additional, Gulanchyn, K., additional, Hannah, C.-L., additional, Hays, J., additional, Hendrickson, J., additional, Hester, J., additional, Holmes, K., additional, Johnson, A., additional, Jopek, C., additional, Lewin, H., additional, Lyons, J., additional, Manley, C., additional, Meden, J., additional, Moore, S., additional, Moore, W.H., additional, Murthy, V., additional, Nace, R., additional, Neely, D., additional, Nelson, L., additional, Niedermaier, O., additional, Rice, D., additional, Rigs, R., additional, Schiffer, K., additional, Schockling, E., additional, Schultz, T., additional, Schumacker, T., additional, Sheesley, B., additional, Sheikh, A., additional, Siegel, B., additional, Slim, A.M., additional, Smith, J., additional, Szulc, M., additional, Tanskersley, N., additional, Tilkemeier, P., additional, Valdez, G.D., additional, Vrooman, R., additional, Wawrowicz, D., additional, Winchester, D.E., additional, Alcheikh, A., additional, Allen, B., additional, Atkins, E., additional, Bevan, J., additional, Bonomini, C., additional, Christiansen, J., additional, Clack, L., additional, Craig, E., additional, Dixson, H., additional, Duncan, I., additional, Fredericks, S., additional, Gales, S., additional, Hampson, R., additional, Hanley, T., additional, Hartcher, K., additional, Hassall, J., additional, Kelley, B., additional, Kelly, S., additional, Kidd, T., additional, de Kort, T., additional, Larcos, G., additional, Macdonald, W., additional, McGrath, C., additional, Murdoch, E., additional, O'Malley, S., additional, O'Rourke, M., additional, Pack, M., additional, Pearce, R., additional, Praehofer, R., additional, Ramsay, S., additional, Scarlett, L., additional, Smidt, K., additional, Souvannavong, F., additional, Taubman, K., additional, Taylor, G., additional, Tse, K., additional, Unger, S., additional, and Weale, J., additional

Published
2021
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33. An unusual pediatric case of an intradiploic epidermoid cyst with cranial bone invasion

Author

Kalliopi Petropoulou, Ramsay S. Farah, Stephanie Zyck, George W. Koutsouras, Timothy E. Richardson, Michael Weingarten, Satish Krishnamurthy, and Mary Beth Gadarowski

Subjects
scalloping, Computed tomography, Case Report, Dermatology, Bone erosion, Lesion, lesion, cranial bone invasion, lcsh:Dermatology, Medicine, large, medicine.diagnostic_test, business.industry, bone erosion, Epidermoid cyst, Anatomy, lcsh:RL1-803, medicine.disease, intradiploic, CT, computed tomography, pediatric, Cranial bone, bony sclerosis, epidermoid cyst, medicine.symptom, CNS, business, Bony sclerosis
Published
2020

34. Acquired anhidrosis in a patient with Sjogren syndrome and silicone breast implants

Author

Ramsay S. Farah, Mary Beth Gadarowski, Tatsiana Pukhalskaya, and Bruce R. Smoller

Subjects
medicine.medical_specialty, acquired anhidrosis, Case Report, Dermatology, Sjögren syndrome, silicone breast implants, chemistry.chemical_compound, Eccrine gland, Silicone, lcsh:Dermatology, Medicine, xerosis, Silicone breast implant, Sjogren syndrome, Anhidrosis, hypohidrosis, business.industry, eccrine glands, autoimmune, lcsh:RL1-803, medicine.disease, localized anhidrosis, chemistry, medicine.symptom, business, SS, Sjogren syndrome, SBI, silicone breast implant
Published
2020

37. γ-Glutamyl-β-phenylethylamine, a novel α-glucosidase and α-amylase inhibitory compound from Termitomyces robustus, an edible Nigerian mushroom.

Author

Ogbole, Omonike O., Noleto-Dias, Clarice, Kamdem, Ramsay S. T., Akinleye, Toluwanimi E., Nkumah, Abraham, Ward, Jane L., and Beale, Michael H.

Subjects
EDIBLE mushrooms, AMYLASES, ALPHA-glucosidases, FRUITING bodies (Fungi), DRUG standards, NATURAL products, ACARBOSE
Abstract

Termitomyces species are known edible mushrooms in Nigeria, believed to have exceptional culinary and nutraceutical properties. Methanol extract from fruiting bodies of Termitomyces robustus was evaluated for antidiabetic activity using in vitro α-amylase and α-glucosidase assays. The isolation and structural elucidation of metabolites from the T. robustus extract afforded five compounds including a new natural product γ-glutamyl-β-phenylethylamine 3 and four known phenyl derivatives: tryptophan 1, 4-hydroxyphenylacetic acid 2, 4-hydroxyphenylpropionic acid 4, and phenyllactic acid 5. Structures were elucidated from analyses of spectroscopic data (1 D and 2 D NMR, HRESIMS) and all isolated compounds were tested for α-amylase and α-glycosidase inhibitory activity. The in vitro assay established crude extract to possess α- amylase and α-glucosidase inhibition with IC50 of 78.05 µg/mL and 86.10 µg/mL, respectively. The isolated compounds compared favourably with the standard drug, acarbose with IC50 ranging from 6.18-15.08 µg/mL and 18.28-44.63 µg/mL for α-amylase and glucosidase, respectively. [ABSTRACT FROM AUTHOR]

Published
2022
Full Text
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39. Worldwide Diagnostic Reference Levels for Single-Photon Emission Computed Tomography Myocardial Perfusion Imaging: Findings From INCAPS

Author

Hirschfeld, C. B., Dondi, M., Pascual, T. N. B., Mercuri, M., Vitola, J., Karthikeyan, G., Better, N., Mahmarian, J. J., Bouyoucef, S. E., Hee-Seung Bom, H., Lele, V., Magboo, V. P. C., Alexanderson, E., Allam, A. H., Al-Mallah, M. H., Flotats, A., Jerome, S., Kaufmann, P. A., Luxenburg, O., Underwood, S. R., Rehani, M. M., Vassileva, J., Paez, D., Einstein, A. J., Kashyap, R., Meeks, J. B., Mut, F., Vitola, J. V., Allam, A., Bom, H., Mahmarian, J., Shaw, L. J., Amouri, W., Essabbah, H., Gassama, S. S., Makhdomi, K. B., El Mustapha, G. I. E., El Ouchdi, N., Qais, N., Soni, N., Vangu, W., Abazid, R. M., Adams, B., Agarwal, V., Alfeeli, M. A., Alnafisi, N., Bernabe, L., Bural, G. G., Chaiwatanarat, T., Chandraguptha, J. M., Cheon, G. J., Cho, I., Dogan, A. S., Eftekhari, M., Frenkel, A., Garty, I., George, S., Geramifar, P., Golan, H., Habib, S., Hussain, R., Im, H., Jeon, H. -J., Kalawat, T., Kang, W. J., Keng, F., Klaipetch, A., Kumar, P. G., Lee, J., Lee, W. W., Lim, I., Macaisa, C. M. M., Malhotra, G., Mittal, B. R., Mohammad, M. H., Mohan, P., Mulyanto, I. D., Nariman, D., Nayak, U. N., Niaz, K., Nikolov, G., Obaldo, J. M., Ozturk, E., Park, J. M., Park, S., Patel, C. D., Phuong, H. K., Quinon, A. P., Rajini, T. R., Saengsuda, Y., Santiago, J., Sayman, H. B., Shinto, A. S., Sivasubramaniyan, V., Son, M. H., Sudhakar, P., Syed, G. M. S., Tamaki, N., Thamnirat, K., Thientunyakit, T., Thongmak, S., Velasco, D. N., Verma, A., Vutrapongwatana, U., Wang, Y., Won, K. S., Yao, Z., Yingsa-nga, T., Yudistiro, R., Yue, K. T., Zafrir, N., Adrian, S. C., Agostini, D., Aguade, S., Armitage, G., Backlund, M., Backman, M., Baker, M., Balducci, M. T., Bavelaar, C., Berovic, M., Bertagna, F., Beuchel, R., Biggi, A., Bisi, G., Bonini, R., Bradley, A., Brudin, L., Bruno, I., Busnardo, E., Casoni, R., Choudhri, A., Cittanti, C., Clauss, R., Costa, D. C., Costa, M., Dixon, K., Dziuk, M., Egelic, N., Eriksson, I., Fagioli, G., de Faria, D. B., Florimonte, L., Francini, A., French, M., Gallagher, E., Garai, I., Geatti, O., Genovesi, D., Gianolli, L., Gimelli, A., del Giudice, E., Halliwell, S., Hansson, M. J., Harrison, C., Homans, F., Horton, F., Jedrzejuk, D., Jogi, J., Johansen, A., Johansson, H., Kalnina, M., Kaminek, M., Kiss, A., Kobylecka, M., Kostkiewicz, M., Kropp, J., Kullenberg, R., Lahoutte, T., Lang, O., Larsson, Y. H., Lazar, M., Leccisotti, L., Leners, N., Lindner, O., Lipp, R. W., Maenhout, A., Maffioli, L., Marcassa, C., Martins, B., Marzullo, P., Medolago, G., Mendiguchia, C. G., Mirzaei, S., Mori, M., Nardi, B., Nazarenko, S., Nikoletic, K., Oleksa, R., Parviainen, T., Patrina, J., Peace, R., Pirich, C., Piwowarska-Bilska, H., Popa, S., Prakash, V., Pubul, V., Puklavec, L., Rac, S., Ratniece, M., Rogan, S. A., Romeo, A., Rossi, M., Ruiz, D., Sabharwal, N., Salobir, B. G., Santos, A. I., Saranovic, S., Sarkozi, A., Schneider, R. P., Sciagra, R., Scotti, S., Servini, Z., Setti, L. R., Starck, S. -A., Vajauskas, D., Vesely, J., Vieni, A., Vignati, A., Vito, I. M., Weiss, K., Wild, D., Zdraveska-Kochovska, M., Aguro, R. N., Alvarado, N., Barral, C. M., Beretta, M., Berrocal, I., Cuellar, J. F. B., Chang, T. -M. C., Rodriguez, L. O. C., Canessa, J., Mora, G. C., AGABITI-ROSEI, Claudia, Clavelo, G. F., Junior, A. F. C., Faccio, F. F., Fernandez, K. M., Garibo, J. R. G., Gonzalez, U., Gonzalez E, P., Guzzo, M. A., Jofre, J., Kapitan, M., Kempfer, G., Lopez, J. L., Massardo V, T., Colaco, I. M., Mesquita, C. T., Montecinos, M., Neubauer, S., Pabon, L. M., Puente, A., Vazquez, L. M. R., Macias, J. A. S., Pino, A. G. S., Huber, F. Z. T., Tovar, A. P., Vargas, L., Wiefels, C., Aljizeeri, A., Alvarez, R. J., Barger, D., Beardwood, W., Behrens, J., Brann, L., Brown, D., Carr, H., Churchwell, K., Comingore, G. A., Corbett, J., Costello, M., Cruz, F., Depinet, T., Dorbala, S., Earles, M., Esteves, F. P., Etherton, E., Fanning, R. J., Fornace, J., Franks, L., Gewirtz, H., Gulanchyn, K., Hannah, C. -L., Hays, J., Hendrickson, J., Hester, J., Holmes, K., Johnson, A., Jopek, C., Lewin, H., Lyons, J., Manley, C., Meden, J., Moore, S., Moore, W. H., Murthy, V., Nace, R., Neely, D., Nelson, L., Niedermaier, O., Rice, D., Rigs, R., Schiffer, K., Schockling, E., Schultz, T., Schumacker, T., Sheesley, B., Sheikh, A., Siegel, B., Slim, A. M., Smith, J., Szulc, M., Tanskersley, N., Tilkemeier, P., Valdez, G. D., Vrooman, R., Wawrowicz, D., Winchester, D. E., Alcheikh, A., Allen, B., Atkins, E., Bevan, J., Bonomini, C., Christiansen, J., Clack, L., Craig, E., Dixson, H., Duncan, I., Fredericks, S., Gales, S., Hampson, R., Hanley, T., Hartcher, K., Hassall, J., Kelley, B., Kelly, S., Kidd, T., de Kort, T., Larcos, G., Macdonald, W., Mcgrath, C., Murdoch, E., O'Malley, S., O'Rourke, M., Pack, M., Pearce, R., Praehofer, R., Ramsay, S., Scarlett, L., Smidt, K., Souvannavong, F., Taubman, K., Taylor, G., Tse, K., Unger, S., and Weale, J.

Subjects
administered activity, diagnostic reference level, radiation dose reduction, SPECT myocardial perfusion imaging, NO
Published
2021

40. Worldwide Diagnostic Reference Levels for Single-Photon Emission Computed Tomography Myocardial Perfusion Imaging

Author

Hirschfeld, Cole B., primary, Dondi, Maurizio, additional, Pascual, Thomas N.B., additional, Mercuri, Mathew, additional, Vitola, Joao, additional, Karthikeyan, Ganesan, additional, Better, Nathan, additional, Mahmarian, John J., additional, Bouyoucef, Salah E., additional, Hee-Seung Bom, Henry, additional, Lele, Vikram, additional, Magboo, Vincent Peter C., additional, Alexánderson, Erick, additional, Allam, Adel H., additional, Al-Mallah, Mouaz H., additional, Flotats, Albert, additional, Jerome, Scott, additional, Kaufmann, Philipp A., additional, Luxenburg, Osnat, additional, Underwood, S. Richard, additional, Rehani, Madan M., additional, Vassileva, Jenia, additional, Paez, Diana, additional, Einstein, Andrew J., additional, Einstein, A.J., additional, Pascual, T.N.B., additional, Paez, D., additional, Dondi, M., additional, Better, N., additional, Bouyoucef, S.E., additional, Karthikeyan, G., additional, Kashyap, R., additional, Lele, V., additional, Magboo, V.P.C., additional, Mahmarian, J.J., additional, Meeks, J.B., additional, Mercuri, M., additional, Mut, F., additional, Rehani, M.M., additional, Vitola, J.V., additional, Alexanderson, E., additional, Allam, A., additional, Al-Mallah, M.H., additional, Bom, H., additional, Flotats, A., additional, Jerome, S., additional, Kaufmann, P.A., additional, Luxenburg, O., additional, Mahmarian, J., additional, Shaw, L.J., additional, Underwood, S.R., additional, Vitola, J., additional, Amouri, W., additional, Essabbah, H., additional, Gassama, S.S., additional, Makhdomi, K.B., additional, El Mustapha, G.I.E., additional, El Ouchdi, N., additional, Qaïs, N., additional, Soni, N., additional, Vangu, W., additional, Abazid, R.M., additional, Adams, B., additional, Agarwal, V., additional, Alfeeli, M.A., additional, Alnafisi, N., additional, Bernabe, L., additional, Bural, G.G., additional, Chaiwatanarat, T., additional, Chandraguptha, J.M., additional, Cheon, G.J., additional, Cho, I., additional, Dogan, A.S., additional, Eftekhari, M., additional, Frenkel, A., additional, Garty, I., additional, George, S., additional, Geramifar, P., additional, Golan, H., additional, Habib, S., additional, Hussain, R., additional, Im, H., additional, Jeon, H.-J., additional, Kalawat, T., additional, Kang, W.J., additional, Keng, F., additional, Klaipetch, A., additional, Kumar, P.G., additional, Lee, J., additional, Lee, W.W., additional, Lim, I., additional, Macaisa, C.M.M., additional, Malhotra, G., additional, Mittal, B.R., additional, Mohammad, M.H., additional, Mohan, P., additional, Mulyanto, I.D., additional, Nariman, D., additional, Nayak, U.N., additional, Niaz, K., additional, Nikolov, G., additional, Obaldo, J.M., additional, Ozturk, E., additional, Park, J.M., additional, Park, S., additional, Patel, C.D., additional, Phuong, H.K., additional, Quinon, A.P., additional, Rajini, T.R., additional, Saengsuda, Y., additional, Santiago, J., additional, Sayman, H.B., additional, Shinto, A.S., additional, Sivasubramaniyan, V., additional, Son, M.H., additional, Sudhakar, P., additional, Syed, G.M.S., additional, Tamaki, N., additional, Thamnirat, K., additional, Thientunyakit, T., additional, Thongmak, S., additional, Velasco, D.N., additional, Verma, A., additional, Vutrapongwatana, U., additional, Wang, Y., additional, Won, K.S., additional, Yao, Z., additional, Yingsa-nga, T., additional, Yudistiro, R., additional, Yue, K.T., additional, Zafrir, N., additional, Adrian, S.C., additional, Agostini, D., additional, Aguadé, S., additional, Armitage, G., additional, Backlund, M., additional, Backman, M., additional, Baker, M., additional, Balducci, M.T., additional, Bavelaar, C., additional, Berovic, M., additional, Bertagna, F., additional, Beuchel, R., additional, Biggi, A., additional, Bisi, G., additional, Bonini, R., additional, Bradley, A., additional, Brudin, L., additional, Bruno, I., additional, Busnardo, E., additional, Casoni, R., additional, Choudhri, A., additional, Cittanti, C., additional, Clauss, R., additional, Costa, D.C., additional, Costa, M., additional, Dixon, K., additional, Dziuk, M., additional, Egelic, N., additional, Eriksson, I., additional, Fagioli, G., additional, de Faria, D.B., additional, Florimonte, L., additional, Francini, A., additional, French, M., additional, Gallagher, E., additional, Garai, I., additional, Geatti, O., additional, Genovesi, D., additional, Gianolli, L., additional, Gimelli, A., additional, del Giudice, E., additional, Halliwell, S., additional, Hansson, M.J., additional, Harrison, C., additional, Homans, F., additional, Horton, F., additional, Jędrzejuk, D., additional, Jogi, J., additional, Johansen, A., additional, Johansson, H., additional, Kalnina, M., additional, Kaminek, M., additional, Kiss, A., additional, Kobylecka, M., additional, Kostkiewicz, M., additional, Kropp, J., additional, Kullenberg, R., additional, Lahoutte, T., additional, Lang, O., additional, Larsson, Y.H., additional, Lázár, M., additional, Leccisotti, L., additional, Leners, N., additional, Lindner, O., additional, Lipp, R.W., additional, Maenhout, A., additional, Maffioli, L., additional, Marcassa, C., additional, Martins, B., additional, Marzullo, P., additional, Medolago, G., additional, Mendiguchía, C.G., additional, Mirzaei, S., additional, Mori, M., additional, Nardi, B., additional, Nazarenko, S., additional, Nikoletic, K., additional, Oleksa, R., additional, Parviainen, T., additional, Patrina, J., additional, Peace, R., additional, Pirich, C., additional, Piwowarska-Bilska, H., additional, Popa, S., additional, Prakash, V., additional, Pubul, V., additional, Puklavec, L., additional, Rac, S., additional, Ratniece, M., additional, Rogan, S.A., additional, Romeo, A., additional, Rossi, M., additional, Ruiz, D., additional, Sabharwal, N., additional, Salobir, B.G., additional, Santos, A.I., additional, Saranovic, S., additional, Sarkozi, A., additional, Schneider, R.P., additional, Sciagra, R., additional, Scotti, S., additional, Servini, Z., additional, Setti, L.R., additional, Starck, S.-Å., additional, Vajauskas, D., additional, Veselý, J., additional, Vieni, A., additional, Vignati, A., additional, Vito, I.M., additional, Weiss, K., additional, Wild, D., additional, Zdraveska-Kochovska, M., additional, Agüro, R.N., additional, Alvarado, N., additional, Barral, C.M., additional, Beretta, M., additional, Berrocal, I., additional, Cuellar, J.F. Batista, additional, Chang, T-M. Cabral, additional, Rodríguez, L.O. Cabrera, additional, Canessa, J., additional, Mora, G. Castro, additional, Claudia, A.C., additional, Clavelo, G.F., additional, Júnior, A.F. Cruz, additional, Faccio, F.F., additional, Fernández, K.M., additional, Garibo, J.R. Gomez, additional, Gonzalez, U., additional, González E, P., additional, Guzzo, M.A., additional, Jofre, J., additional, Kapitán, M., additional, Kempfer, G., additional, Lopez, J.L., additional, Massardo V, T., additional, Colaco, I. Medeiros, additional, Mesquita, C.T., additional, Montecinos, M., additional, Neubauer, S., additional, Pabon, L.M., additional, Puente, A., additional, Vazquez, L.M. Rochela, additional, Macias, J.A. Serna, additional, Pino, A.G. Silva, additional, Huber, F.Z. Tártari, additional, Tovar, A.P., additional, Vargas, L., additional, Wiefels, C., additional, Aljizeeri, A., additional, Alvarez, R.J., additional, Barger, D., additional, Beardwood, W., additional, Behrens, J., additional, Brann, L., additional, Brown, D., additional, Carr, H., additional, Churchwell, K., additional, Comingore, G.A., additional, Corbett, J., additional, Costello, M., additional, Cruz, F., additional, Depinet, T., additional, Dorbala, S., additional, Earles, M., additional, Esteves, F.P., additional, Etherton, E., additional, Fanning, R.J., additional, Fornace, J., additional, Franks, L., additional, Gewirtz, H., additional, Gulanchyn, K., additional, Hannah, C.-L., additional, Hays, J., additional, Hendrickson, J., additional, Hester, J., additional, Holmes, K., additional, Johnson, A., additional, Jopek, C., additional, Lewin, H., additional, Lyons, J., additional, Manley, C., additional, Meden, J., additional, Moore, S., additional, Moore, W.H., additional, Murthy, V., additional, Nace, R., additional, Neely, D., additional, Nelson, L., additional, Niedermaier, O., additional, Rice, D., additional, Rigs, R., additional, Schiffer, K., additional, Schockling, E., additional, Schultz, T., additional, Schumacker, T., additional, Sheesley, B., additional, Sheikh, A., additional, Siegel, B., additional, Slim, A.M., additional, Smith, J., additional, Szulc, M., additional, Tanskersley, N., additional, Tilkemeier, P., additional, Valdez, G.D., additional, Vrooman, R., additional, Wawrowicz, D., additional, Winchester, D.E., additional, Alcheikh, A., additional, Allen, B., additional, Atkins, E., additional, Bevan, J., additional, Bonomini, C., additional, Christiansen, J., additional, Clack, L., additional, Craig, E., additional, Dixson, H., additional, Duncan, I., additional, Fredericks, S., additional, Gales, S., additional, Hampson, R., additional, Hanley, T., additional, Hartcher, K., additional, Hassall, J., additional, Kelley, B., additional, Kelly, S., additional, Kidd, T., additional, de Kort, T., additional, Larcos, G., additional, Macdonald, W., additional, McGrath, C., additional, Murdoch, E., additional, O'Malley, S., additional, O'Rourke, M., additional, Pack, M., additional, Pearce, R., additional, Praehofer, R., additional, Ramsay, S., additional, Scarlett, L., additional, Smidt, K., additional, Souvannavong, F., additional, Taubman, K., additional, Taylor, G., additional, Tse, K., additional, Unger, S., additional, and Weale, J., additional

Published
2021
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41. Impact of age on the selection of nuclear cardiology stress protocols: The INCAPS (IAEA nuclear cardiology protocols) study

Author

Al-Mallah, Mh, Pascual, Tnb, Mercuri, M, Vitola, Jv, Karthikeyan, G, Better, N, Dondi, M, Paez, D, Eistein, Aj, Bouyoucef, Se, Allam, Ah, Vangu, M, Rehani, Mm, Kashyap, R, Lele, V, Magboo, Vpc, Mahmarian, Jj, Mut, F, Alexánderson, E, Allam, A, Bom, H, Flotats, A, Jerome, S, Kaufmann, Pa, Luxenburg, O, Mahmarian, J, Shaw, Lj, Underwood, Sr, Amouri, W, Essabbah, H, Gassama, Ss, Makhdomi, Kb, El Mustapha, Gie, El Ouchdi, N, Qaïs, N, Soni, N, Vangu, W, Abazid, Rm, Adams, B, Agarwal, V, Alfeeli, Ma, Alnafisi, N, Bernabe, L, Bural, Gg, Chaiwatanarat, T, Chandraguptha, Jm, Cheon, Gj, Cho, I, Dogan, As, Eftekhari, M, Frenkel, A, Garty, I, George, S, Geramifar, P, Golan, H, Habib, S, Hussain, R, Im, H, Jeon, H-J, Kalawat, T, Kang, Wj, Keng, F, Klaipetch, A, Kumar, Pg, Lee, J, Lee, Ww, Lim, I, Macaisa, Cmm, Malhotra, G, Mittal, Br, Mohammad, Mh, Mohan, P, Mulyanto, Id, Nariman, D, Nayak, Un, Niaz, K, Nikolov, G, Obaldo, Jm, Ozturk, E, Park, Jm, Park, S, Patel, Cd, Phuong, Hk, Quinon, Ap, Rajini, Tr, Saengsuda, Y, Santiago, J, Sayman, Hb, Shinto, As, Sivasubramaniyan, V, Son, Mh, Sudhakar, P, Syed, Gms, Tamaki, N, Thamnirat, K, Thientunyakit, T, Thongmak, S, Velasco, Dn, Verma, A, Vutrapongwatana, U, Wang, Y, Won, Ks, Yao, Z, Yingsa-Nga, T, Yudistiro, R, Yue, Kt, Zafrir, N, Adrian, Sc, Agostini, D, Aguadé, S, Armitage, G, Backlund, M, Backman, M, Baker, M, Balducci, Mt, Bavelaar, C, Berovic, M, Bertagna, F, Beuchel, R, Biggi, A, Bisi, G, Bonini, R, Bradley, A, Brudin, L, Bruno, I, Busnardo, E, Casoni, R, Choudhri, A, Cittanti, C, Clauss, R, Costa, Dc, Costa, M, Dixon, K, Dziuk, M, Egelic, N, Eriksson, I, Fagioli, G, De Faria, Db, Florimonte, L, Francini, Alberto, French, M, Gallagher, E, Garai, I, Geatti, O, Genovesi, D, Gianolli, L, Gimelli, A, Del Giudice, E, Halliwell, S, Hansson, Mj, Harrison, C, Homans, F, Horton, F, Jȩdrzejuk, D, Jogi, J, Johansen, A, Johansson, H, Kalnina, M, Kaminek, M, Kiss, A, Kobylecka, M, Kostkiewicz, M, Kropp, J, Kullenberg, R, Lahoutte, T, Lang, O, Larsson, Yh, Lázár, M, Leccisotti, L, Leners, N, Lindner, O, Lipp, Rw, Maenhout, A, Maffioli, L, Marcassa, C, Martins, B, Marzullo, P, Medolago, G, Mendiguchía, Cg, Mirzaei, S, Mori, M, Nardi, B, Nazarenko, S, Nikoletic, K, Oleksa, R, Parviainen, T, Patrina, J, Peace, R, Pirich, C, Piwowarska-Bilska, H, Popa, S, Prakash, V, Pubul, V, Puklavec, L, Rac, S, Ratniece, M, Rogan, Sa, Romeo, Annunziata, Rossi, M, Ruiz, D, Sabharwal, N, Salobir, Bg, Santos, Ai, Saranovic, S, Sarkozi, A, Schneider, Rp, Sciagra, R, Scotti, S, Servini, Z, Setti, Lr, Starck, S-A., Vajauskas, D, Veselý, J, Vieni, A, Vignati, A, Vito, I. M., Weiss, K, Wild, D, Zdraveska-Kochovska, M, Agüro, Rn, Alvarado, N, Barral, Cm, Beretta, M, Berrocal, I, Batista Cuellar, Jf, Cabral Chang, T-M, Cabrera Rodríguez, Lo, Canessa, J, Castro Mora, G, Claudia, Ac, Clavelo, Gf, Cruz, Af, Faccio, Ff, Fernández, Km, Gomez Garibo, Jr, Gonzalez, U, González, Pe, Guzzo, Ma, Jofre, J, Kapitán, M, Kempfer, G, Lopez, Jl, Massardo, Tv, Medeiros Colaco, I, Mesquita, Ct, Montecinos, M, Neubauer, S, Pabon, Lm, Puente, A, Rochela Vazquez, Lm, Serna Macias, Ja, Silva Pino, Ag, Tártari Huber, Fz, Tovar, Ap, Vargas, L, Wiefels, C, Aljizeeri, A, Alvarez, Rj, Barger, D, Beardwood, W, Behrens, J, Brann, L, Brown, D, Carr, H, Churchwell, K, Comingore, Ga, Corbett, J, Costello, M, Cruz, F, Depinet, T, Dorbala, S, Earles, M, Esteves, Fp, Etherton, E, Fanning, Rj, Fornace, J, Franks, L, Gewirtz, H, Gulanchyn, K, Hannah, C-L, Hays, J, Hendrickson, J, Hester, J, Holmes, K, Johnson, A, Jopek, C, Lewin, H, Lyons, J, Manley, C, Meden, J, Moore, S, Moore, Wh, Murthy, V, Nace, R, Neely, D, Nelson, L, Niedermaier, O, Rice, D, Rigs, R, Schiffer, K, Schockling, E, Schultz, T, Schumacker, T, Sheesley, B, Sheikh, A, Siegel, B, Slim, Am, Smith, J, Szulc, Mc, Tanskersley, N, Tilkemeier, P, Valdez, Gd, Vrooman, R, Wawrowicz, D, Winchester, De, Alcheikh, A, Allen, B, Atkins, E, Bevan, J, Bonomini, C, Christiansen, J, Clack, L, Craig, E, Dixson, H, Duncan, I, Fredericks, S, Gales, S, Hampson, R, Hanley, T, Hartcher, K, Hassall, J, Kelley, B, Kelly, S, Kidd, T, De Kort, T, Larcos, G, Macdonald, W, Mcgrath, C, Murdoch, E, O'Malley, S, O'Rourke, M, Pack, M, Pearce, R, Praehofer, R, Ramsay, S, Scarlett, L, Smidt, K, Souvannavong, F, Taubman, K, Taylor, G, Tse, K, Unger, S, and Weale, J

Subjects
Ionizing radiation, Male, medicine.medical_specialty, Cross-sectional study, Cardiology, Guidelines, 030204 cardiovascular system & hematology, Radiation Dosage, Effective dose (radiation), NO, Cohort Studies, 03 medical and health sciences, Myocardial perfusion imaging, Age, 0302 clinical medicine, Internal medicine, Humans, Medicine, 030212 general & internal medicine, Tomography, Age Factors, Aged, Cross-Sectional Studies, Female, Middle Aged, Myocardial Perfusion Imaging, Positron-Emission Tomography, Practice Guidelines as Topic, Radiation Exposure, Retrospective Studies, Tomography, Emission-Computed, Single-Photon, Nuclear Energy, medicine.diagnostic_test, business.industry, Retrospective cohort study, Radiation exposure, Cohort, Emission-Computed, Cardiology and Cardiovascular Medicine, business, Single-Photon, Cohort study
Abstract

There is growing concern about radiation exposure from nuclear myocardial perfusion imaging (MPI), particularly among younger patients who are more prone to develop untoward effects of ionizing radiation, and hence US and European professional society guidelines recommend age as a consideration in weighing radiation risk from MPI. We aimed to determine how patient radiation doses from MPI vary across age groups in a large contemporary international cohort.Data were collected as part of a global cross-sectional study of centers performing MPI coordinated by the International Atomic Energy Agency (IAEA). Sites provided information on each MPI study completed during a single week in March-April 2013. We compared across age groups laboratory adherence to pre-specified radiation-related best practices, radiation effective dose (ED; a whole-body measure reflecting the amount of radiation to each organ and its relative sensitivity to radiation's deleterious effects), and the proportion of patients with ED ≤ 9 mSv, a target level specified in guidelines.Among 7911 patients undergoing MPI in 308 laboratories in 65 countries, mean ED was 10.0 ± 4.5 mSv with slightly higher exposure among younger age groups (trend p value 0.001). There was no difference in the proportion of patients with ED ≤ 9 mSv across age groups, or in adherence to best practices based on the median age of patients in a laboratory.In contemporary nuclear cardiology practice, the age of the patient appears not to impact protocol selection and radiation dose, contrary to professional society guidelines.

Published
2018

46. Nuclear cardiology practices and radiation exposure in Africa: results from the IAEA Nuclear Cardiology Protocols Study (INCAPS)

Author

Bouyoucef, Salah E., Mercuri, Mathew, Pascual, Thomas N. B., Allam, Adel H., Vangu, Mboyo, Vitola, João V., Better, Nathan, Karthikeyan, Ganesan, Mahmarian, John J., Rehani, Madan M., Kashyap, Ravi, Dondi, Maurizio, Paez, Diana, Einstein, Andrew J., Einstein, A. J., Pascual, T. N. B., Paez, D., Dondi, M., Better, N., Bouyoucef, S. E., Karthikeyan, G., Kashyap, R., Lele, V., Magboo, V. P. C., Mahmarian, J. J., Mercuri, M., Mut, F., Rehani, M. M., Vitola, J. V., Alexánderson, E., Allam, A., Al-Mallah, M. H., Bom, H., Flotats, A., Jerome, S., Kaufmann, P. A., Luxenburg, O., Mahmarian, J., Shaw, L. J., Underwood, S. R., Vitola, J., Amouri, W., Essabbah, H., Gassama, S. S., Makhdomi, K. B., El Mustapha, G. I. E., El Ouchdi, N., Qaïs, N., Soni, N., Vangu, W., Abazid, R. M., Adams, B., Agarwal, V., Alfeeli, M. A., Alnafisi, N., Bernabe, L., Bural, G. G., Chaiwatanarat, T., Chandraguptha, J. M., Cheon, G. J., Cho, I., Dogan, A. S., Eftekhari, M., Frenkel, A., Garty, I., George, S., Geramifar, P., Golan, H., Habib, S., Hussain, R., Im, H., Jeon, H. -J., Kalawat, T., Kang, W. J., Keng, F., Klaipetch, A., Kumar, P. G., Lee, J., Lee, W. W., Lim, I., Macaisa, C. M. M., Malhotra, G., Mittal, B. R., Mohammad, M. H., Mohan, P., Mulyanto, I. D., Nariman, D., Nayak, U. N., Niaz, K., Nikolov, G., Obaldo, J. M., Ozturk, E., Park, J. M., Park, S., Patel, C. D., Phuong, H. K., Quinon, A. P., Rajini, T. R., Saengsuda, Y., Santiago, J., Sayman, H. B., Shinto, A. S., Sivasubramaniyan, V., Son, M. H., Sudhakar, P., Syed, G. M. S., Tamaki, N., Thamnirat, K., Thientunyakit, T., Thongmak, S., Velasco, D. N., Verma, A., Vutrapongwatana, U., Wang, Y., Won, K. S., Yao, Z., Yingsa-Nga, T., Yudistiro, R., Yue, K. T., Zafrir, N., Adrian, S. C., Agostini, D., Aguadé, S., Armitage, G., Backlund, M., Backman, M., Baker, M., Balducci, M. T., Bavelaar, C., Berovic, M., Bertagna, F., Beuchel, R., Biggi, A., Bisi, G., Bonini, R., Bradley, A., Brudin, L., Bruno, I., Busnardo, E., Casoni, R., Choudhri, A., Cittanti, C., Clauss, R., Costa, D. C., Costa, M., Dixon, K., Dziuk, M., Egelic, N., Eriksson, I., Fagioli, G., De Faria, D. B., Florimonte, L., Francini, A., French, M., Gallagher, E., Garai, I., Geatti, O., Genovesi, D., Gianolli, L., Gimelli, A., Del Giudice, E., Halliwell, S., Hansson, M. J., Harrison, C., Homans, F., Horton, F., Jȩdrzejuk, D., Jogi, J., Johansen, A., Johansson, H., Kalnina, M., Kaminek, M., Kiss, A., Kobylecka, M., Kostkiewicz, M., Kropp, J., Kullenberg, R., Lahoutte, T., Lang, O., Larsson, Y. H., Lázár, M., Leccisotti, L., Leners, N., Lindner, O., Lipp, R. W., Maenhout, A., Maffioli, L., Marcassa, C., Martins, B., Marzullo, P., Medolago, G., Mendiguchía, C. G., Mirzaei, S., Mori, M., Nardi, B., Nazarenko, S., Nikoletic, K., Oleksa, R., Parviainen, T., Patrina, J., Peace, R., Pirich, C., Piwowarska-Bilska, H., Popa, S., Prakash, V., Pubul, V., Puklavec, L., Rac, S., Ratniece, M., Rogan, S. A., Romeo, A., Rossi, M., Ruiz, D., Sabharwal, N., Salobir, B. G., Santos, A. I., Saranovic, S., Sarkozi, A., Schneider, R. P., Sciagra, R., Scotti, S., Servini, Z., Setti, L. R., Starck, S-Ã…., Vajauskas, D., Veselý, J., Vieni, A., Vignati, A., Vito, I. M., Weiss, K., Wild, D., Zdraveska-Kochovska, M., Agüro, R. N., Alvarado, N., Barral, C. M., Beretta, M., Berrocal, I., Batista Cuellar, J. F., Cabral Chang, T. -M., Cabrera Rodríguez, L. O., Canessa, J., Castro Mora, G., Claudia, A. C., Clavelo, G. F., Cruz, A. F., Faccio, F. F., Fernández, K. M., Gomez Garibo, J. R., Gonzalez, U., González, P. E., Guzzo, M. A., Jofre, J., Kapitán, M., Kempfer, G., Lopez, J. L., Massardo, T. V., Medeiros Colaco, I., Mesquita, C. T., Montecinos, M., Neubauer, S., Pabon, L. M., Puente, A., Rochela Vazquez, L. M., Serna Macias, J. A., Silva Pino, A. G., Tártari Huber, F. Z., Tovar, A. P., Vargas, L., Wiefels, C., Aljizeeri, A., Alvarez, R. J., Barger, D., Beardwood, W., Behrens, J., Brann, L., Brown, D., Carr, H., Churchwell, K., Comingore, G. A., Corbett, J., Costello, M., Cruz, F., Depinet, T., Dorbala, S., Earles, M., Esteves, F. P., Etherton, E., Fanning, R. J., Fornace, J., Franks, L., Gewirtz, H., Gulanchyn, K., Hannah, C. -L., Hays, J., Hendrickson, J., Hester, J., Holmes, K., Johnson, A., Jopek, C., Lewin, H., Lyons, J., Manley, C., Meden, J., Moore, S., Moore, W. H., Murthy, V., Nace, R., Neely, D., Nelson, L., Niedermaier, O., Rice, D., Rigs, R., Schiffer, K., Schockling, E., Schultz, T., Schumacker, T., Sheesley, B., Sheikh, A., Siegel, B., Slim, A. M., Smith, J., Szulc, M. C., Tanskersley, N., Tilkemeier, P., Valdez, G. D., Vrooman, R., Wawrowicz, D., Winchester, D. E., Alcheikh, A., Allen, B., Atkins, E., Bevan, J., Bonomini, C., Christiansen, J., Clack, L., Craig, E., Dixson, H., Duncan, I., Fredericks, S., Gales, S., Hampson, R., Hanley, T., Hartcher, K., Hassall, J., Kelley, B., Kelly, S., Kidd, T., De Kort, T., Larcos, G., Macdonald, W., Mcgrath, C., Murdoch, E., O'Malley, S., O'Rourke, M., Pack, M., Pearce, R., Praehofer, R., Ramsay, S., Scarlett, L., Smidt, K., Souvannavong, F., Taubman, K., Taylor, G., Tse, K., Unger, S., and Weale, J.

Subjects
Male, medicine.medical_specialty, Heart Diseases, Cross-sectional study, MEDLINE, effective dose, Cardiology, 030204 cardiovascular system & hematology, Effective dose (radiation), NO, 030218 nuclear medicine & medical imaging, CONSECUTIVE SAMPLE, 03 medical and health sciences, Myocardial perfusion imaging, 0302 clinical medicine, Interquartile range, Internal medicine, medicine, best practices, Humans, Registries, Africa, Best practices, Effective dose, Radiation, Aged, Cross-Sectional Studies, Female, Incidence, Middle Aged, Myocardial Perfusion Imaging, Radiation Exposure, Radiation Injuries, Tomography, Emission-Computed, Single-Photon, Cardiology and Cardiovascular Medicine, Tomography, medicine.diagnostic_test, business.industry, Cardiovascular Topics, Radiation dose, General Medicine, Radiation exposure, radiation, Emission-Computed, business, Single-Photon
Abstract

OBJECTIVE While nuclear myocardial perfusion imaging (MPI) offers many benefits to patients with known or suspected cardiovascular disease, concerns exist regarding radiation-associated health effects. Little is known regarding MPI practice in Africa. We sought to characterise radiation doses and the use of MPI best practices that could minimise radiation in African nuclear cardiology laboratories, and compare these to practice worldwide. METHODS Demographics and clinical characteristics were collected for a consecutive sample of 348 patients from 12 laboratories in six African countries over a one-week period from March to April 2013. Radiation effective dose (ED) was estimated for each patient. A quality index (QI) enumerating adherence to eight best practices, identified a priori by an IAEA expert panel, was calculated for each laboratory. We compared these metrics with those from 7 563 patients from 296 laboratories outside Africa. RESULTS Median (interquartile range) patient ED in Africa was similar to that of the rest of the world [9.1 (5.1-15.6) vs 10.3 mSv (6.8-12.6), p = 0.14], although a larger proportion of African patients received a low ED, ≤ 9 mSv targeted in societal recommendations (49.7 vs 38.2%, p < 0.001). Bestpractice adherence was higher among African laboratories (QI score: 6.3 ± 1.2 vs 5.4 ± 1.3, p = 0.013). However, median ED varied significantly among African laboratories (range: 2.0-16.3 mSv; p < 0.0001) and QI range was 4-8. CONCLUSION Patient radiation dose from MPI in Africa was similar to that in the rest of the world, and adherence to best practices was relatively high in African laboratories. Nevertheless there remain opportunities to further reduce radiation exposure to African patients from MPI.

Published
2017

47. The VAMPIRE challenge: A multi-institutional validation study of CT ventilation imaging

Author

Kipritidis, J, Tahir, BA, Cazoulat, G, Hofman, MS, Siva, S, Callahan, J, Hardcastle, N, Yamamoto, T, Christensen, GE, Reinhardt, JM, Kadoya, N, Patton, TJ, Gerard, SE, Duarte, I, Archibald-Heeren, B, Byrne, M, Sims, R, Ramsay, S, Booth, JT, Eslick, E, Hegi-Johnson, F, Woodruff, HC, Ireland, RH, Wild, JM, Cai, J, Bayouth, JE, Brock, K, Keall, PJ, Kipritidis, J, Tahir, BA, Cazoulat, G, Hofman, MS, Siva, S, Callahan, J, Hardcastle, N, Yamamoto, T, Christensen, GE, Reinhardt, JM, Kadoya, N, Patton, TJ, Gerard, SE, Duarte, I, Archibald-Heeren, B, Byrne, M, Sims, R, Ramsay, S, Booth, JT, Eslick, E, Hegi-Johnson, F, Woodruff, HC, Ireland, RH, Wild, JM, Cai, J, Bayouth, JE, Brock, K, and Keall, PJ

Abstract

PURPOSE: CT ventilation imaging (CTVI) is being used to achieve functional avoidance lung cancer radiation therapy in three clinical trials (NCT02528942, NCT02308709, NCT02843568). To address the need for common CTVI validation tools, we have built the Ventilation And Medical Pulmonary Image Registration Evaluation (VAMPIRE) Dataset, and present the results of the first VAMPIRE Challenge to compare relative ventilation distributions between different CTVI algorithms and other established ventilation imaging modalities. METHODS: The VAMPIRE Dataset includes 50 pairs of 4DCT scans and corresponding clinical or experimental ventilation scans, referred to as reference ventilation images (RefVIs). The dataset includes 25 humans imaged with Galligas 4DPET/CT, 21 humans imaged with DTPA-SPECT, and 4 sheep imaged with Xenon-CT. For the VAMPIRE Challenge, 16 subjects were allocated to a training group (with RefVI provided) and 34 subjects were allocated to a validation group (with RefVI blinded). Seven research groups downloaded the Challenge dataset and uploaded CTVIs based on deformable image registration (DIR) between the 4DCT inhale/exhale phases. Participants used DIR methods broadly classified into B-splines, Free-form, Diffeomorphisms, or Biomechanical modeling, with CT ventilation metrics based on the DIR evaluation of volume change, Hounsfield Unit change, or various hybrid approaches. All CTVIs were evaluated against the corresponding RefVI using the voxel-wise Spearman coefficient rS , and Dice similarity coefficients evaluated for low function lung ( DSClow ) and high function lung ( DSChigh ). RESULTS: A total of 37 unique combinations of DIR method and CT ventilation metric were either submitted by participants directly or derived from participant-submitted DIR motion fields using the in-house software, VESPIR. The rS and DSC results reveal a high degree of inter-algorithm and intersubject variability among the validation subjects, with algorithm rankings chang

Published
2019

48. The MICADO first light imager for the ELT: overview and current status

Author

Bryant, Julia J., Motohara, Kentaro, Vernet, Joël R. D., Sturm, E., Davies, R., Alves, J., Clénet, Y., Kotilainen, J., Monna, A., Nicklas, H., Pott, J.-U., Tolstoy, E., Vulcani, B., Achren, J., Annadevara, S., Anwand-Heerwart, H., Arcidiacono, C., Barboza, S., Barl, L., Baudoz, P., Bender, R., Bezawada, N., Biondi, F., Bizenberger, P., Blin, A., Boné, A., Bonifacio, P., Borgo, B., Born, J. van den, Buey, T., Cao, Y., Chapron, F., Chauvin, G., Chemla, F., Cloiseau, K., Cohen, M., Colin, C., Czoske, O., Dette, J.-O., Deysenroth, M., Dijkstra, E., Dreizler, S., Dupuis, O., Egmond, G. van, Eisenhauer, F., Elswijk, E., Emslander, A., Fabricius, M., Fasola, G., Ferreira, F., Förster Schreiber, N., Fontana, A., Gaudemard, J., Gautherot, N., Gendron, E., Gennet, C., Genzel, R., Ghouchou, L., Gillessen, S., Gratadour, D., Grazian, A., Grupp, F., Guieu, S., Gullieuszik, M., Haan, M. de, Hartke, J., Hartl, M., Haussmann, F., Helin, T., Hess, H.-J., Hofferbert, R., Huber, H., Huby, E., Huet, J.-M., Ives, D., Janssen, A., Jaufmann, P., Jilg, T., Jodlbauer, D., Jost, J., Kausch, W., Kellermann, H., Kerber, F., Kravcar, H., Kravchenko, K., Kulcsár, C., Kuncarayakti, H., Kunst, P., Kwast, S., Lang, F., Lange, J., Lapeyrere, V., Le Ruyet, B., Leschinski, K., Locatelli, H., Massari, D., Mattila, S., Mei, S., Merlin, F., Meyer, E., Michel, C., Mohr, L., Montargès, M., Müller, F., Münch, N., Navarro, R., Neumann, U., Neumayer, N., Neumeier, L., Pedichini, F., Pflüger, A., Piazzesi, R., Pinard, L., Porras, J., Portulari, E., Przybilla, N., Rabien, S., Raffard, J., Ragazzoni, R., Ramlau, R., Ramos, J., Ramsay, S., Raynaud, H.-F., Rhode, P., Richter, A., Rix, H.-W., Rodenhuis, M., Rohloff, R.-R., Romp, R., Rousselot, P., Sabha, N., Sassolas, B., Schlichter, J., Schuil, M., Schweitzer, M., Seemann, U., Sevin, A., Simioni, M., Spallek, L., Sönmez, A., Suuronen, J., Taburet, S., Thomas, J., Tisserand, E., Vaccari, P., Valenti, E., Verdoes Kleijn, G., Verdugo, M., Vidal, F., Wagner, R., Wegner, M., Winden, D. van, Witschel, J., Zanella, A., Zeilinger, W., Ziegleder, J., and Ziegler, B.

Published
2024
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49. Glycosides of ursane-type triterpenoid, benzophenone, and iridoid from

Author

Ahmed Galal, Osman, Zulfiqar, Ali, Omer, Fantoukh, Vijayasankar, Raman, Ramsay S T, Kamdem, and Ikhlas, Khan

Subjects
Benzophenones, Magnetic Resonance Spectroscopy, Anti-Infective Agents, Iridoids, Rubiaceae, Glycosides, Plant Roots, Triterpenes
Abstract

Four ursane-type triterpenoid glycosides (

Published
2018

50. The MICADO first light imager for the ELT: overview, operation, simulation

Author

Barl, L., Baudoz, P., Bender, R., Bizenberger, P., Buey, T., Chemla, F., Cohen, M., Czoske, O., Disseau, K., Dreizler, S., Fabricius, M., Geis, N., Gemperlein, H., Genzel, R., Glück, M., Hartl, M., Häuser, M., Hofferbert, R., Hopp, U., Hubert, Z., Huby, E., Huet, M., Hutterer, V., Ives, D., Janssen, A., Jellema, W., Kausch, W., Kerber, F., Kravcar, H., Leschinski, K., Mandla, C., Manhart, M., Mohr, L., Neumann, U., Neumayer, N., Richter, A., Richter, J., Rodeghiero, G., Rosensteiner, M., Schlichter, J., Schubert, J., Thomas, J., Wegner, M., Zeilinger, W., Ziegleder, J., Ziegler, B., Zins, G., Davies, Richard, Alves, João, Clénet, Yann, Lang-Bardl, Florian, Nicklas, Harald, Pott, Jorg-Uwe, Ragazzoni, Roberto, Tolstoy, Eline, Amico, P., Anwand-Heerwart, H., Barboza, S., Bezawada, N., Boland, W., Bonifacio, P., Borgo, Bruno, Chapron, F., Déo, V., Dupuis, O., Falomo, R., Fédou, P., Förster Schreiber, N., Garrel, V., Gendron, E., Gillessen, S., Grupp, F., Hess, H., Hörmann, V., Le Ruyet, B., Massari, D., Mei, S., Merlin, F., Monna, A., Muench, N., Müller, F., Musters, G., Navarro, R., Niebsch, J., Plattner, M., Przybilla, N., Rabien, S., Ramlau, R., Ramos, J., Ramsay, S., Rhode, P., Rix, H., Rohloff, R., Rousset, G., Sevin, A., Stuik, R., Sturm, E., Tromp, N., Verdoes-Kleijn, G., Vidal, F., Wagner, R., Takami, Hideki, Evans, J., Simard, Luc, Laboratoire d'études spatiales et d'instrumentation en astrophysique (LESIA), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Galaxies, Etoiles, Physique, Instrumentation (GEPI), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, Centre Hospitalier Universitaire de Nice (CHU Nice), Services communs OMP (UMS 831), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire Midi-Pyrénées (OMP), Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Centre National de la Recherche Scientifique (CNRS), Max Planck Institute for Extraterrestrial Physics (MPE), Max-Planck-Gesellschaft, Faculty of Mechanical Engineering, Brno University of Technology [Brno] (BUT), Institut für Kernphysik, Technische Universität Darmstadt (TU Darmstadt), Ludwig-Maximilians-Universität München (LMU), Space Sciences, Technologies and Astrophysics Research Institute (STAR), Université de Liège, European Southern Observatory (ESO), Laboratoire de recherche en Hydrodynamique, Énergétique et Environnement Atmosphérique (LHEEA), École Centrale de Nantes (ECN)-Centre National de la Recherche Scientifique (CNRS), Department of General, Institute of Environmental Physics [Bremen] (IUP), University of Bremen, Institut de Planétologie et d'Astrophysique de Grenoble (IPAG), Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Observatoire des Sciences de l'Univers de Grenoble (OSUG ), Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut national des sciences de l'Univers (INSU - CNRS)-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), Virginia Commonwealth University (VCU), Max-Planck-Institut für Astronomie (MPIA), INAF - Osservatorio Astronomico di Padova (OAPD), Istituto Nazionale di Astrofisica (INAF), Institut d'astrophysique spatiale (IAS), Université Paris-Sud - Paris 11 (UP11)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), Départment Gynécologie et Obstétrique, Hospices Civils de Lyon (HCL), Max-Planck-Institut für Extraterrestrische Physik (MPE), Laboratoire d'Astrophysique de Marseille (LAM), Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Aix Marseille Université (AMU)-Centre National d'Études Spatiales [Toulouse] (CNES), Anthropologie Moléculaire et Imagerie de Synthèse (AMIS), Centre National de la Recherche Scientifique (CNRS)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées, Laboratoire de Physico-chimie des Polymères et des Interfaces (LPPI), Fédération INSTITUT DES MATÉRIAUX DE CERGY-PONTOISE (I-MAT), Université de Cergy Pontoise (UCP), Université Paris-Seine-Université Paris-Seine-Université de Cergy Pontoise (UCP), Université Paris-Seine-Université Paris-Seine, Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, CHU Pessac, Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire Midi-Pyrénées (OMP), Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Institut de Recherche pour le Développement (IRD)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Centre National de la Recherche Scientifique (CNRS), Technische Universität Darmstadt - Technical University of Darmstadt (TU Darmstadt), Université Paris-Sud - Paris 11 (UP11)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Centre National d’Études Spatiales [Paris] (CNES), Aix Marseille Université (AMU)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS), Université de Toulouse (UT)-Université de Toulouse (UT)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris Diderot - Paris 7 (UPD7)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS), and Bonifacio, Piercarlo

Subjects
[SDU.ASTR]Sciences of the Universe [physics]/Astrophysics [astro-ph], [SDU.ASTR] Sciences of the Universe [physics]/Astrophysics [astro-ph], ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2018

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