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2. Towards retrospective motion correction and reconstruction for clinical 3D brain MRI protocols with a reference contrast

Author

Rizzuti, Gabrio, Schakel, Tim, Huttinga, Niek R. F., Dankbaar, Jan Willem, van Leeuwen, Tristan, and Sbrizzi, Alessandro

Subjects
Electrical Engineering and Systems Science - Image and Video Processing
Abstract

Motion artifacts often spoil the radiological interpretation of MR images, and in the most severe cases the scan needs be repeated, with additional costs for the provider. We discuss the application of a novel 3D retrospective rigid motion correction and reconstruction scheme for MRI, which leverages multiple scans contained in a MR session. Typically, in a multi-contrast MR session, motion does not equally affect all the scans, and some motion-free scans are generally available, so that we can exploit their anatomic similarity. The uncorrupted scan is used as a reference in a generalized rigid-motion registration problem to remove the motion artifacts affecting the corrupted scans. We discuss the potential of the proposed algorithm with a prospective in-vivo study and clinical 3D brain protocols. This framework can be easily incorporated into the existing clinical practice with no disruption to the conventional workflow.

Published
2023

6. Improved Delineation with Diffusion Weighted Imaging for Laryngeal and Hypopharyngeal Tumors Validated with Pathology

Author

Smits, Hilde J.G., primary, Raaijmakers, Cornelis P. J., additional, de Ridder, Mischa, additional, Gouw, Zeno A. R., additional, Doornaert, Patricia A. H., additional, Pameijer, Frank A., additional, Lodeweges, Joyce E., additional, Ruiter, Lilian N., additional, Kuijer, Koen M., additional, Schakel, Tim, additional, de Bree, Remco, additional, Dankbaar, Jan W., additional, Breimer, Gerben E., additional, Terhaard, Chris H.J., additional, Willems, Stefan M., additional, and Philippens, Marielle E. P., additional

Published
2024
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12. Optimized flip angle schemes for the split acquisition of fast spin-echo signals (SPLICE) sequence and application to diffusion-weighted imaging

Author

Rahbek, Sofie, Schakel, Tim, Mahmood, Faisal, Madsen, Kristoffer H., Philippens, Marielle E.P., Hanson, Lars G., Rahbek, Sofie, Schakel, Tim, Mahmood, Faisal, Madsen, Kristoffer H., Philippens, Marielle E.P., and Hanson, Lars G.

Abstract

Purpose: The diffusion-weighted SPLICE (split acquisition of fast spin-echo signals) sequence employs split-echo rapid acquisition with relaxation enhancement (RARE) readout to provide images almost free of geometric distortions. However, due to the varying T (Formula presented.) -weighting during k-space traversal, SPLICE suffers from blurring. This work extends a method for controlling the spatial point spread function (PSF) while optimizing the signal-to-noise ratio (SNR) achieved by adjusting the flip angles in the refocusing pulse train of SPLICE. Methods: An algorithm based on extended phase graph (EPG) simulations optimizes the flip angles by maximizing SNR for a flexibly chosen predefined target PSF that describes the desired k-space density weighting and spatial resolution. An optimized flip angle scheme and a corresponding post-processing correction filter which together achieve the target PSF was tested by healthy subject brain imaging using a clinical 1.5 T scanner. Results: Brain images showed a clear and consistent improvement over those obtained with a standard constant flip angle scheme. SNR was increased and apparent diffusion coefficient estimates were more accurate. For a modified Hann k-space weighting example, considerable benefits resulted from acquisition weighting by flip angle control. Conclusion: The presented flexible method for optimizing SPLICE flip angle schemes offers improved MR image quality of geometrically accurate diffusion-weighted images that makes the sequence a strong candidate for radiotherapy planning or stereotactic surgery.

Published
2023

16. Towards retrospective motion correction and reconstruction for clinical 3D brain MRI protocols with a reference contrast

Author

Gabrio Rizzuti, Schakel, Tim, Huttinga, Niek R F, Dankbaar, Jan Willem, Van Leeuwen, Tristan, and Sbrizzi, Alessandro

Subjects
Image and Video Processing (eess.IV), FOS: Electrical engineering, electronic engineering, information engineering, Electrical Engineering and Systems Science - Image and Video Processing
Abstract

Motion artifacts often spoil the radiological interpretation of MR images, and in the most severe cases the scan needs be repeated, with additional costs for the provider. We discuss the application of a novel 3D retrospective rigid motion correction and reconstruction scheme for MRI, which leverages multiple scans contained in a MR session. Typically, in a multi-contrast MR session, motion does not equally affect all the scans, and some motion-free scans are generally available, so that we can exploit their anatomic similarity. The uncorrupted scan is used as a reference in a generalized rigid-motion registration problem to remove the motion artifacts affecting the corrupted scans. We discuss the potential of the proposed algorithm with a prospective in-vivo study and clinical 3D brain protocols. This framework can be easily incorporated into the existing clinical practice with no disruption to the conventional workflow.

Published
2023

18. Feasibility of cardiac-synchronized quantitative T1 and T2 mapping on a hybrid 1.5 Tesla magnetic resonance imaging and linear accelerator system

Author

Experimentele klinische fysica, Cancer, Computational Imaging, Klinische Fysica RT, Team Medisch, Circulatory Health, MS Radiotherapie, MS Radiologie, Akdag, Osman, Mandija, Stefano, van Lier, Astrid L H M W, Borman, PTS, Schakel, Tim, Alberts, Eveline, van der Heide, Oscar, Hassink, Rutger J, Verhoeff, Joost J C, Mohamed Hoesein, Firdaus A A, Raaymakers, Bas W, Fast, Martin F, Experimentele klinische fysica, Cancer, Computational Imaging, Klinische Fysica RT, Team Medisch, Circulatory Health, MS Radiotherapie, MS Radiologie, Akdag, Osman, Mandija, Stefano, van Lier, Astrid L H M W, Borman, PTS, Schakel, Tim, Alberts, Eveline, van der Heide, Oscar, Hassink, Rutger J, Verhoeff, Joost J C, Mohamed Hoesein, Firdaus A A, Raaymakers, Bas W, and Fast, Martin F

Published
2022

19. Pushing functional MRI spatial and temporal resolution further: High-density receive arrays combined with shot-selective 2D CAIPIRINHA for 3D echo-planar imaging at 7 T

Author

Hendriks, Arjan D, D'Agata, Federico, Raimondo, Luisa, Schakel, Tim, Geerts, Liesbeth, Luijten, Peter R, Klomp, Dennis W J, Petridou, Natalia, Hendriks, Arjan D, D'Agata, Federico, Raimondo, Luisa, Schakel, Tim, Geerts, Liesbeth, Luijten, Peter R, Klomp, Dennis W J, and Petridou, Natalia

Abstract

To be able to examine dynamic and detailed brain functions, the spatial and temporal resolution of 7 T MRI needs to improve. In this study, it was investigated whether submillimeter multishot 3D EPI fMRI scans, acquired with high-density receive arrays, can benefit from a 2D CAIPIRINHA sampling pattern, in terms of noise amplification (g-factor), temporal SNR and fMRI sensitivity. High-density receive arrays were combined with a shot-selective 2D CAIPIRINHA implementation for multishot 3D EPI sequences at 7 T. In this implementation, in contrast to conventional inclusion of extra kz gradient blips, specific EPI shots are left out to create a CAIPIRINHA shift and reduction of scan time. First, the implementation of the CAIPIRINHA sequence was evaluated with a standard receive setup by acquiring submillimeter whole brain T2 *-weighted anatomy images. Second, the CAIPIRINHA sequence was combined with high-density receive arrays to push the temporal resolution of submillimeter 3D EPI fMRI scans of the visual cortex. Results show that the shot-selective 2D CAIPIRINHA sequence enables a reduction in scan time for 0.5 mm isotropic 3D EPI T2 *-weighted anatomy scans by a factor of 4 compared with earlier reports. The use of the 2D CAIPIRINHA implementation in combination with high-density receive arrays, enhances the image quality of submillimeter 3D EPI scans of the visual cortex at high acceleration as compared to conventional SENSE. Both the g-factor and temporal SNR improved, resulting in a method that is more sensitive to the fMRI signal. Using this method, it is possible to acquire submillimeter single volume 3D EPI scans of the visual cortex in a subsecond timeframe. Overall, high-density receive arrays in combination with shot-selective 2D CAIPIRINHA for 3D EPI scans prove to be valuable for reducing the scan time of submillimeter MRI acquisitions.

Published
2020

20. Pushing functional MRI spatial and temporal resolution further: High-density receive arrays combined with shot-selective 2D CAIPIRINHA for 3D echo-planar imaging at 7 T

Author

Highfield Research Group, Cancer, Computational Imaging, Fysica Radiotherapie Research, Divisie Beeld & Oncologie, Divisie Beeld, Brain, Circulatory Health, Regenerative Medicine and Stem Cells, Hendriks, Arjan D, D'Agata, Federico, Raimondo, Luisa, Schakel, Tim, Geerts, Liesbeth, Luijten, Peter R, Klomp, Dennis W J, Petridou, Natalia, Highfield Research Group, Cancer, Computational Imaging, Fysica Radiotherapie Research, Divisie Beeld & Oncologie, Divisie Beeld, Brain, Circulatory Health, Regenerative Medicine and Stem Cells, Hendriks, Arjan D, D'Agata, Federico, Raimondo, Luisa, Schakel, Tim, Geerts, Liesbeth, Luijten, Peter R, Klomp, Dennis W J, and Petridou, Natalia

Published
2020

22. Diffusion weighted MRI for tumor delineation in head and neck radiotherapy

Author

Schakel, Tim, Lagendijk, JJW, Terhaard, CHJ, Philippens, Marielle, Hoogduin, JM, and University Utrecht

Subjects
delineation, diffusion, head and neck cancer, radiotherapy, MRI
Abstract

In radiotherapy treatments of head and neck cancer, ionizing radiation is used to destroy malignant tumor tissue, while sparing the surrounding healthy tissue. For successful delivery of radiotherapy treatments, an accurate definition of the target is essential. This target is defined using threedimensional imaging techniques such as computed tomography (CT), positron emission tomography (PET) and magnetic resonance imaging (MRI). MRI can visualize, amongst others, local differences in the diffusion of water: diffusion weighted MRI (DW-MRI). Tumors have different diffusion characteristics than normal tissue. With DW-MRI these differences can be visualized and used in target volume delineation. In order to use DW-MRI in a radiotherapy setting, geometric accuracy is vital. The most common method to acquire DW-MRI, DW-EPI, is known for its sensitivity to geometric distortions, especially in areas with large magnetic field inhomogeneities. The geometric accuracy of DW-EPI was evaluated in patients with a retrospective analysis of magnetic field maps. It was found that severe geometric distortions are present when using DW-EPI in the head and neck region. Therefore, the use of an alternative acquisition method, DW-SPLICE, was proposed. This method is based on a turbo spin echo sequence, which is used for standard anatomical imaging and has comparable, high geometric accuracy. The method was implemented and demonstrated in patients. Using DW-SPLICE, diffusion weighted images with excellent geometric accuracy were acquired in head and neck cancer patients. Additionally, the DW-SPLICE technique was extended in order to improve fat suppression. Additional images were acquired in order to yield a dataset which was suitable for water fat separation. The results from the water fat separation were applied in order to provide a more robust and homogeneous fat suppression. The diffusion weighted images acquired with DW-SPLICE were used to generate target volume delineations. Using an intensity threshold, an initial volume was segmented on diffusion weighted images. Subsequently these were manually adjusted based on the diffusion coefficients. These delineations were compared with those based on PET. Pathology validation of PET delineations has shown these to be quite accurate. The (semi-)automatic target volume delineations on DW-SPLICE show good correspondence with target volume delineations based on PET, indicating that, for a large part, both techniques indicate the same target for treatment. Using surgical specimens, obtained after total laryngectomy, pathological validation of DW-MRI can be performed. Patients received an MRI exam with DW-MRI prior to surgery. The surgical specimen of the larynx was processed, resulting in a digitally reconstructed threedimensional volume which was matched to the imaging prior to surgery. The initial results from the first patient show that the target volume delineation based on DW-MRI has very good agreement with the tumor defined on pathology. When diffusion weighted images are acquired with good geometrical accuracy, these images can be a valuable addition for target volume delineation in head and neck radiotherapy.

Published
2018

24. Target Volume Delineation Using Diffusion-weighted Imaging for MR-guided Radiotherapy : A Case Series of Laryngeal Cancer Validated by Pathology

Author

Ligtenberg, Hans, Schakel, Tim, Dankbaar, Jan Willem, Ruiter, Lilian N, Peltenburg, Boris, Willems, Stefan M, Kasperts, Nicolien, Terhaard, Chris H J, Raaijmakers, Cornelis P J, Philippens, Marielle E P, Ligtenberg, Hans, Schakel, Tim, Dankbaar, Jan Willem, Ruiter, Lilian N, Peltenburg, Boris, Willems, Stefan M, Kasperts, Nicolien, Terhaard, Chris H J, Raaijmakers, Cornelis P J, and Philippens, Marielle E P

Published
2018

26. Target Volume Delineation Using Diffusion-weighted Imaging for MR-guided Radiotherapy: A Case Series of Laryngeal Cancer Validated by Pathology

Author

Fysica Radiotherapie Research, Cancer, MS Radiologie, Circulatory Health, Brain, Pathologie Groep Moelans, Onderzoek Radiotherapie, Pathologie Pathologen staf, MS Radiotherapie, Klinische Fysica RT, Ligtenberg, Hans, Schakel, Tim, Dankbaar, Jan Willem, Ruiter, Lilian N, Peltenburg, Boris, Willems, Stefan M, Kasperts, Nicolien, Terhaard, Chris H J, Raaijmakers, Cornelis P J, Philippens, Marielle E P, Fysica Radiotherapie Research, Cancer, MS Radiologie, Circulatory Health, Brain, Pathologie Groep Moelans, Onderzoek Radiotherapie, Pathologie Pathologen staf, MS Radiotherapie, Klinische Fysica RT, Ligtenberg, Hans, Schakel, Tim, Dankbaar, Jan Willem, Ruiter, Lilian N, Peltenburg, Boris, Willems, Stefan M, Kasperts, Nicolien, Terhaard, Chris H J, Raaijmakers, Cornelis P J, and Philippens, Marielle E P

Published
2018

27. Diffusion weighted MRI with minimal distortion in head-and-neck radiotherapy using a turbo spin echo acquisition method

Author

Schakel, Tim, Hoogduin, JM, Terhaard, Chris H J, and Philippens, Marielle E P

Subjects
image distortions, head-and-neck cancer, diffusion, Journal Article, mri, radiotherapy
Abstract

PURPOSE: Diffusion weighted (DW) MRI, showing high contrast between tumor and background tissue, is a promising technique in radiotherapy for tumor delineation. However, its use for head-and-neck patients is hampered by poor geometric accuracy in conventional echo planar imaging (EPI) DW-MRI. An alternative turbo spin echo sequence, DW-SPLICE, is implemented and demonstrated in patients. METHODS: The DW-SPLICE sequence was implemented on a 3.0T system and evaluated in 10 patients. The patients were scanned in treatment position, using a customized head support and immobilization mask. Image distortions were quantified at the gross tumor volume (GTV) using field map analysis. The apparent diffusion coefficient (ADC) was evaluated using an ice water phantom. RESULTS: The DW images acquired by DW-SPLICE showed no image distortions. Field map analysis at the gross tumor volumes resulted in a median distortion of 0.2 mm for DW-SPLICE, whereas for the conventional method this was 7.2 mm. ADC values, measured using an ice water phantom were in accordance with literature values. CONCLUSIONS: The implementation of DW-SPLICE allows for diffusion weighted imaging of patients in treatment position with excellent geometrical accuracy. The images can be used to facilitate target volume delineation in RT treatment planning. This article is protected by copyright. All rights reserved.

Published
2017

28. Target Volume Delineation Using Diffusion-weighted Imaging for MR-guided Radiotherapy: A Case Series of Laryngeal Cancer Validated by Pathology

Author

Ligtenberg, Hans, primary, Schakel, Tim, additional, Dankbaar, Jan Willem, additional, Ruiter, Lilian N, additional, Peltenburg, Boris, additional, Willems, Stefan M, additional, Kasperts, Nicolien, additional, Terhaard, Chris H J, additional, Raaijmakers, Cornelis P J, additional, and Philippens, Marielle E P, additional

Published
2018
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29. Diffusion weighted MRI with minimal distortion in head-and-neck radiotherapy using a turbo spin echo acquisition method

Author

Fysica Radiotherapie Research, Cancer, Highfield Research Group, Brain, MS Radiotherapie, Klinische Fysica RT, Schakel, Tim, Hoogduin, JM, Terhaard, Chris H J, Philippens, Marielle E P, Fysica Radiotherapie Research, Cancer, Highfield Research Group, Brain, MS Radiotherapie, Klinische Fysica RT, Schakel, Tim, Hoogduin, JM, Terhaard, Chris H J, and Philippens, Marielle E P

Published
2017

30. Modality-specific target definition for laryngeal and hypopharyngeal cancer on FDG-PET, CT and MRI

Author

Fysica Radiotherapie Research, Cancer, Onderzoek Radiotherapie, MS Radiologie, MS Radiotherapie, Pathologie Pathologen staf, Klinische Fysica RT, Ligtenberg, Hans, Jager, Lisanne, Caldas Magalhaes, J, Schakel, Tim, Pameijer, Frank A., Kasperts, Nicolien, Willems, Stefan M., Terhaard, Chris H J, Raaijmakers, CPJ, Philippens, Marielle E P, Fysica Radiotherapie Research, Cancer, Onderzoek Radiotherapie, MS Radiologie, MS Radiotherapie, Pathologie Pathologen staf, Klinische Fysica RT, Ligtenberg, Hans, Jager, Lisanne, Caldas Magalhaes, J, Schakel, Tim, Pameijer, Frank A., Kasperts, Nicolien, Willems, Stefan M., Terhaard, Chris H J, Raaijmakers, CPJ, and Philippens, Marielle E P

Published
2017

31. Validated guidelines for tumor delineation on magnetic resonance imaging for laryngeal and hypopharyngeal cancer

Author

Jager, Elise Anne, Ligtenberg, Hans, Caldas-Magalhaes, Joana, Schakel, Tim, Philippens, Marielle E., Pameijer, Frank A., Kasperts, Nicolien, Willems, Stefan M., Terhaard, Christiaan H., and Raaijmakers, Cornelis P.

Abstract

Background: Validation of magnetic resonance imaging (MRI) and development of guidelines for the delineation of the gross tumor volume (GTV) is of utmost importance to benefit from the visibility of anatomical details on MR images and to achieve an accurate GTV delineation. In the ideal situation, the GTV delineation corresponds to the histopathologically determined ‘true tumor volume’. Consequently, we developed guidelines for GTV delineation of laryngeal and hypopharyngeal tumors on MRI and determined the accuracy of the resulting delineation of the tumor outline on histopathology as gold standard. Material and methods: Twenty-seven patients with T3 or T4 laryngeal/hypopharyngeal cancer underwent a MRI scan before laryngectomy. Hematoxylin and eosin sections were obtained from surgical specimens and tumor was delineated by one pathologist. GTV was delineated on MR images by three independent observers in two sessions. The first session (del1) was performed according to clinical practice. In the second session (del2) guidelines were used. The reconstructed specimen was registered to the MR images for comparison of the delineated GTVs to the tumor on histopathology. Volumes and overlap parameters were analyzed. A target margin needed to assure tumor coverage was determined. Results: The median GTVs (del1: 19.4 cm3, del2: 15.8 cm3) were larger than the tumor volume on pathology (10.5 cm3). Comparable target margins were needed for both delineation sessions to assure tumor coverage. By adding these margins to the GTVs, the target volumes for del1 (median: 81.3 cm3) were significantly larger than for del2 (median: 64.2 cm3) (p ≤ 0.0001) with similar tumor coverage. Conclusions: In clinical radiotherapy practice, the delineated GTV on MRI is twice as large as the tumor volume. Validated delineation guidelines lead to a significant decrease in the overestimation of the tumor volume.

Published
2016
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32. Interobserver variation among pathologists for delineation of tumor on H&E-sections of laryngeal and hypopharyngeal carcinoma. How good is the gold standard?

Author

Jager, Elise Anne, Willems, Stefan M., Schakel, Tim, Kooij, Nina, Slootweg, Pieter J., Philippens, Marielle E P, Caldas Magalhaes, Joana, Terhaard, Chris H. J., and Raaijmakers, Cornelis P J

Subjects
Letter, Oncology, Radiology Nuclear Medicine and imaging, Research Support, Non-U.S. Gov't, Randomized Controlled Trial, Hematology
Published
2016

34. Integrated Multimodal Imaging of Dynamic Bone-Tumor Alterations Associated with Metastatic Prostate Cancer

Author

Brisset, Jean-Christophe, Hoff, Benjamin A., Chenevert, Thomas L., Jacobson, Jon A., Boes, Jennifer L., Galban, Stefanie, Rehemtulla, Alnawaz, Johnson, Timothy D., Pienta, Kenneth J., Galban, Craig J., Meyer, Charles R., Schakel, Timothy, Nicolay, Klaas, Alva, Ajjai S., Hussain, Maha, Ross, Brian D., and Schakel, Tim

Subjects
Male, Oncology, BIOMARKER, Pathology, Osteolysis, Bone density, Bone disease, FUNCTIONAL DIFFUSION MAP, lcsh:Medicine, PROGRESSION, Docetaxel, SDG 3 – Goede gezondheid en welzijn, Multimodal Imaging, 030218 nuclear medicine & medical imaging, Mice, Prostate cancer, 0302 clinical medicine, Bone Density, Prostate, PARAMETRIC RESPONSE MAP, lcsh:Science, Non-U.S. Gov't, Multidisciplinary, Diphosphonates, Research Support, Non-U.S. Gov't, Bone metastasis, Clinical Trial, Tumor Burden, 3. Good health, THERAPY RESPONSE, Treatment Outcome, medicine.anatomical_structure, 030220 oncology & carcinogenesis, ANDROGEN INDEPENDENCE, Taxoids, Research Article, medicine.medical_specialty, GLIOBLASTOMA, Antineoplastic Agents, Bone Neoplasms, Research Support, N.I.H, 03 medical and health sciences, Breast cancer, SDG 3 - Good Health and Well-being, Research Support, N.I.H., Extramural, DW-MRI, Osteoclast, Internal medicine, medicine, Journal Article, Animals, Humans, BREAST-CANCER, Osteoblasts, business.industry, lcsh:R, Prostatic Neoplasms, Extramural, WEIGHTED MRI, medicine.disease, Disease Models, Animal, Diffusion Magnetic Resonance Imaging, lcsh:Q, business
Abstract

Bone metastasis occurs for men with advanced prostate cancer which promotes osseous growth and destruction driven by alterations in osteoblast and osteoclast homeostasis. Patients can experience pain, spontaneous fractures and morbidity eroding overall quality of life. The complex and dynamic cellular interactions within the bone microenvironment limit current treatment options thus prostate to bone metastases remains incurable. This study uses voxel-based analysis of diffusion-weighted MRI and CT scans to simultaneously evaluate temporal changes in normal bone homeostasis along with prostate bone metatastsis to deliver an improved understanding of the spatiotemporal local microenvironment. Dynamic tumor-stromal interactions were assessed during treatment in mouse models along with a pilot prospective clinical trial with metastatic hormone sensitive and castration resistant prostate cancer patients with bone metastases. Longitudinal changes in tumor and bone imaging metrics during delivery of therapy were quantified. Studies revealed that voxel-based parametric response maps (PRM) of DW-MRI and CT scans could be used to quantify and spatially visualize dynamic changes during prostate tumor growth and in response to treatment thereby distinguishing patients with stable disease from those with progressive disease (p

Published
2015

35. Inter-observer agreement of MRI-based tumor delineation for preoperative radiotherapy boost in locally advanced rectal cancer

Author

Onderzoek Radiotherapie, Experimentele klinische fysica, Cancer, MS Radiotherapie, Klinische Fysica RT, Fysica Radiotherapie Research, Divisie Beeld & Oncologie, Arts-assistenten Radiotherapie, Other research (not in main researchprogram), Burbach, Johannes Peter Maarten, Kleijnen, Jean Paul Johannes, Reerink, Onne, Seravalli, Enrica, Philippens, Marielle E P, Schakel, Tim, van Asselen, B, Raaymakers, Bas W., van Vulpen, Marco, Intven, Martijn, Onderzoek Radiotherapie, Experimentele klinische fysica, Cancer, MS Radiotherapie, Klinische Fysica RT, Fysica Radiotherapie Research, Divisie Beeld & Oncologie, Arts-assistenten Radiotherapie, Other research (not in main researchprogram), Burbach, Johannes Peter Maarten, Kleijnen, Jean Paul Johannes, Reerink, Onne, Seravalli, Enrica, Philippens, Marielle E P, Schakel, Tim, van Asselen, B, Raaymakers, Bas W., van Vulpen, Marco, and Intven, Martijn

Published
2016

36. Validated guidelines for tumor delineation on magnetic resonance imaging for laryngeal and hypopharyngeal cancer

Author

Onderzoek Radiotherapie, Fysica Radiotherapie Research, Cancer, Klinische Fysica RT, MS Radiologie, MS Radiotherapie, Pathologie Pathologen staf, Jager, Elise Anne, Ligtenberg, Hans, Caldas Magalhaes, J, Schakel, Tim, Philippens, Marielle E, Pameijer, Frank A, Kasperts, Nicolien, Willems, Stefan M, Terhaard, CHJ, Raaijmakers, CPJ, Onderzoek Radiotherapie, Fysica Radiotherapie Research, Cancer, Klinische Fysica RT, MS Radiologie, MS Radiotherapie, Pathologie Pathologen staf, Jager, Elise Anne, Ligtenberg, Hans, Caldas Magalhaes, J, Schakel, Tim, Philippens, Marielle E, Pameijer, Frank A, Kasperts, Nicolien, Willems, Stefan M, Terhaard, CHJ, and Raaijmakers, CPJ

Published
2016

37. Interobserver variation among pathologists for delineation of tumor on H&E-sections of laryngeal and hypopharyngeal carcinoma. How good is the gold standard?

Author

Onderzoek Radiotherapie, Pathologie Pathologen staf, Other research (not in main researchprogram), Cancer, Fysica Radiotherapie Research, Klinische Fysica RT, MS Radiotherapie, Jager, Elise Anne, Willems, Stefan M., Schakel, Tim, Kooij, Nina, Slootweg, Pieter J., Philippens, Marielle E P, Caldas Magalhaes, Joana, Terhaard, Chris H. J., Raaijmakers, Cornelis P J, Onderzoek Radiotherapie, Pathologie Pathologen staf, Other research (not in main researchprogram), Cancer, Fysica Radiotherapie Research, Klinische Fysica RT, MS Radiotherapie, Jager, Elise Anne, Willems, Stefan M., Schakel, Tim, Kooij, Nina, Slootweg, Pieter J., Philippens, Marielle E P, Caldas Magalhaes, Joana, Terhaard, Chris H. J., and Raaijmakers, Cornelis P J

Published
2016

39. The accuracy of target delineation in laryngeal and hypopharyngeal cancer

Author

Caldas Magalhaes, J, Kooij, Nina, Ligtenberg, Hans, Jager, Elise A., Schakel, Tim, Kasperts, Nicolien, Pameijer, Frank A., Terhaard, Chris H J, Janssen, Luuk M., Van Diest, Paul J., Philippens, Marielle E P, Raaijmakers, Cornelis P J, Caldas Magalhaes, J, Kooij, Nina, Ligtenberg, Hans, Jager, Elise A., Schakel, Tim, Kasperts, Nicolien, Pameijer, Frank A., Terhaard, Chris H J, Janssen, Luuk M., Van Diest, Paul J., Philippens, Marielle E P, and Raaijmakers, Cornelis P J

Published
2015

40. The accuracy of target delineation in laryngeal and hypopharyngeal cancer

Author

Fysica Radiotherapie Research, Pathologie, Cancer, MS Radiotherapie, MS Radiologie, MS KNO, Other research (not in main researchprogram), Klinische Fysica RT, Caldas Magalhaes, J, Kooij, Nina, Ligtenberg, Hans, Jager, Elise A., Schakel, Tim, Kasperts, Nicolien, Pameijer, Frank A., Terhaard, Chris H J, Janssen, Luuk M., Van Diest, Paul J., Philippens, Marielle E P, Raaijmakers, Cornelis P J, Fysica Radiotherapie Research, Pathologie, Cancer, MS Radiotherapie, MS Radiologie, MS KNO, Other research (not in main researchprogram), Klinische Fysica RT, Caldas Magalhaes, J, Kooij, Nina, Ligtenberg, Hans, Jager, Elise A., Schakel, Tim, Kasperts, Nicolien, Pameijer, Frank A., Terhaard, Chris H J, Janssen, Luuk M., Van Diest, Paul J., Philippens, Marielle E P, and Raaijmakers, Cornelis P J

Published
2015

41. Integrated Multimodal Imaging of Dynamic Bone-Tumor Alterations Associated with Metastatic Prostate Cancer

Author

Fysica Radiotherapie Research, Cancer, Brisset, Jean-Christophe, Hoff, Benjamin A., Chenevert, Thomas L., Jacobson, Jon A., Boes, Jennifer L., Galban, Stefanie, Rehemtulla, Alnawaz, Johnson, Timothy D., Pienta, Kenneth J., Galban, Craig J., Meyer, Charles R., Schakel, Timothy, Nicolay, Klaas, Alva, Ajjai S., Hussain, Maha, Ross, Brian D., Schakel, Tim, Fysica Radiotherapie Research, Cancer, Brisset, Jean-Christophe, Hoff, Benjamin A., Chenevert, Thomas L., Jacobson, Jon A., Boes, Jennifer L., Galban, Stefanie, Rehemtulla, Alnawaz, Johnson, Timothy D., Pienta, Kenneth J., Galban, Craig J., Meyer, Charles R., Schakel, Timothy, Nicolay, Klaas, Alva, Ajjai S., Hussain, Maha, Ross, Brian D., and Schakel, Tim

Published
2015

42. Interobserver variation among pathologists for delineation of tumor on H&E-sections of laryngeal and hypopharyngeal carcinoma. How good is the gold standard?

Author

Jager, Elise Anne, primary, Willems, Stefan M., additional, Schakel, Tim, additional, Kooij, Nina, additional, Slootweg, Pieter J., additional, Philippens, Marielle E. P., additional, Caldas-Magalhaes, Joana, additional, Terhaard, Chris H. J., additional, and Raaijmakers, Cornelis P. J., additional

Published
2015
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43. The accuracy of target delineation in laryngeal and hypopharyngeal cancer

Author

Caldas-Magalhaes, Joana, primary, Kooij, Nina, additional, Ligtenberg, Hans, additional, Jager, Elise A., additional, Schakel, Tim, additional, Kasperts, Nicolien, additional, Pameijer, Frank A., additional, Terhaard, Chris H. J., additional, Janssen, Luuk M., additional, van Diest, Paul J., additional, Philippens, Marielle E. P., additional, and Raaijmakers, Cornelis P. J., additional

Published
2015
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44. 1605: Added value of diffusion weighted MRI on accuracy of laryngeal and hypopharyngeal GTV delineation.

Author

Smits, Hilde J.G., Raaijmakers, Cornelis P.J., Gouw, Zeno A.R., Ruiter, Lilian N., Kuijer, Koen, de Ridder, Mischa, Doornaert, Patricia A.H., Lodeweges, Joyce E., Pameijer, Frank A., Schakel, Tim, de Bree, Remco, Terhaard, Chris H.J., Breimer, Gerben E., Dankbaar, Jan W., Willems, Stefan M., and Philippens, Marielle E.P.

Subjects
*DIFFUSION magnetic resonance imaging
Published
2024
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45. Interobserver variation among pathologists for delineation of tumor on H&E-sections of laryngeal and hypopharyngeal carcinoma. How good is the gold standard?

Author

Jager EA, Willems SM, Schakel T, Kooij N, Slootweg PJ, Philippens ME, Caldas-Magalhaes J, Terhaard CH, and Raaijmakers CP

Subjects
Eosine Yellowish-(YS) chemistry, Hematoxylin chemistry, Humans, Image Processing, Computer-Assisted methods, Neoplasm Staging, Prognosis, Carcinoma, Squamous Cell diagnosis, Hypopharyngeal Neoplasms diagnosis, Laryngeal Neoplasms diagnosis, Observer Variation, Staining and Labeling methods
Published
2016
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