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Angiosarcoma is a rare subtype of soft tissue sarcoma with identifiable vascular differentiation. It can occur at any age and develop throughout the body, but it is most commonly found in skin, soft, and breast tissues. Primary retroperitoneal angiosarcoma is rarely reported in the relevant literature. This article reports a case of primary retroperitoneal angiosarcoma in a middle-aged man, with the relevant literature reviewed in detail. A 46-year-old male had experienced left waist pain for 2 months. An ultrasonic examination revealed a mass in the left retroperitoneum, and left retroperitoneal lesions were confirmed via computed tomography (CT) and magnetic resonance imaging (MRI). The tumor was removed surgically, and the CT scan revealed local tumor recurrence after 1 month when the first adjuvant therapy was performed. The patient died of a massive hemorrhage from a ruptured tumor. Angiosarcoma has high malignancy and a poor prognosis. Its early diagnosis and treatment significantly impact the long-term survival rate of patients.

Objective To explore the performance and mechanism of(+)-corynoline in treating triple negative breast cancer MDA-MB-436 cells and thus provide an option for the development of drugs against this cancer. Methods The viability,proliferation,apoptosis and migration/invasion of MDA-MB-436 cells treated with(+)-corynoline were detected by CCK-8 assay,colony formation assay,flow cytometry and Transwell assay,respectively.Furthermore,Western blotting was employed to determine the expression of related proteins,and RNA-Seq was performed for the MDA-MB-436 cells treated with(+)-corynoline. Results (+)-corynoline inhibited the proliferation and stemness and promoted the apoptosis of MDA-MB-436 cells.Further,(+)-corynoline may activate the oxidative phosphorylation pathway to play a role in inhibiting triple negative breast cancer. Conclusion (+)-corynoline can inhibit triple negative breast cancer cells,which helps to address the poor efficacy of existing chemotherapeutics and facilitate the development of drugs against this cancer.

In this paper, we calculate the energy spectrum of interacting gases by converting the cluster expansion method in statistical mechanics into a method of solving energy eigenvalues. We obtain an explicit expression of the energy eigenvalue, by which we can calculate the eigenvalue of an interacting gas from the interparticle potential directly. As an example, we calculate the energy spectrum for an interacting gas with soft-sphere potentials.

We construct a model for considering the quantum correction of the gravitational constant. In the model, the gravitational constant originates from a coupling between the gravitational field and a scalar field. If the scalar field, as it should be in the real physical world, is a quantum field, the gravitational constant will have a quantum correction. The quantum correction, generally speaking, varies with spacetime coordinates. Therefore, the gravitational constant is no longer a constant. In different spacetime, the quantum correction is different, for the coupling in different spacetime is different. As a result, the gravitational constant in different spacetime is different, though the difference is only at the quantum level. We calculate the quantum correction of the gravitational constant in the Schwarzschild spacetime, the H3 (Euclidean AdS3) spacetime, the H3/ Z spacetime, the universe model, the de Sitter spacetime, and the Rindler spacetime.

Background Liver kinase B1 (LKB1) is involved in various human diseases. Aberrant expression of LKB1 expression is involved in glioma progression and associated with prognosis, however, the specific mechanism involving NF-κB/Snail signaling pathways remain unknown. Materials and methods In the present study, quantitative real-time PCR analysis was used to investigate the expression of LKB1 tumor tissue samples and cell lines. In glioma cell lines, CCK-8 assay, transwell invasion and migration assays were used to investigate the effects of LKB1on proliferation and invasion. Results We observed that LKB1 knockdown promoted glioma cell proliferation, migration and invasion. This effect was induced through NF-κB/Snail signaling activation. Also, LKB1 overexpression suppressed proliferation, migration, and invasion, which could be rescued by Snail overexpression. Conclusion Taken together, our results show that LKB1 knockdown promotes remarkably glioma cell proliferation, migration and invasion by regulating Snail protein expression through activating the NF-κB signaling. This may serve as a potential prognostic marker and therapeutic target for glioma.

We suggest an indirect approach for solving eigenproblems in quantum mechanics. Unlike the usual method, this method is not a technique for solving differential equations. There exists a duality among potentials in quantum mechanics. The first example is the Newton–Hooke duality revealed by Newton in Principia. Potentials that are dual to each other form a duality family consisting of infinite numbers of family members. If one potential in a duality family is solved, the solutions of all other potentials in the family can be obtained by duality transforms. Instead of directly solving the eigenequation of a given potential, we turn to solve one of its dual potentials which is easier to solve. The solution of the given potential can then be obtained from the solution of this dual potential by a duality transform. The approach is as follows: first to construct the duality family of the given potential, then to find a dual potential which is easier to solve in the family and solve it, and finally to obtain the solution of the given potential by the duality transform. In this paper, as examples, we solve exact solutions for general polynomial potentials.

The exact solution of the two-thirds power potential is given. The two-thirds power potential has only bound states.

In this paper, we solve the massive scalar field in the Reissner–Nordstrom spacetime. The scalar field in the Reissner–Nordstrom spacetime has both bound states and scattering states. For bound states, we solve the bound-state wave function and the eigenvalue spectrum. For scattering states, we solve the scattering wave function and give an explicit expression for scattering phase shift by the integral equation method. Especially, we introduce the tortoise coordinate for the Reissner–Nordstrom spacetime. Moreover, in the calculation of scattering cross sections, we encounter a difficulty in partial sum approximation. If the sum of partial waves cannot be performed exactly, one has to turn to the partial sum approximation which approximates a function by the first several terms of the series. However, in the partial sum approximation there exists an incorrect oscillation which cannot be eliminated by keeping more terms. In the appendix we suggest an approach for eliminating such oscillations in the partial sum.

In conventional gravitational wave scattering theory, a large-distance asymptotic approximation is employed. In this approximation, the gravitational wave is approximated by its large-distance asymptotics. In this paper, we establish a gravitational wave scattering theory without the large-distance asymptotic approximation.

The causes of damage during the operation of the container mainly include the different types of goods, the loading and unloading operations of loading and unloading stations, and the rust damage caused by transportation and staying in different areas. Classification of railway container handling stations according to the climate data of the city in which it is located is extremely important for studying the impact of climate on container corrosion. According to the main factors of container corrosion, this paper selected the corresponding climate indicators, writed the crawling program, and collected the original climate data of 320 prefecture-level cities in China from the weather website. Through the preprocessing of data, the paper obtained the basic indicator data of urban climate clustering, and completed analysis by Kmeans clustering method. Sun, rain, salt, and pollution become the main factors in the corrosion of containers. And after cluster analysis, 320 cities are divided into 10-15 clustering groups.

The coal of Anyuan Mine has the characteristic of easy spontaneous combustion. Conventional method is difficult to predict it. Coal samples from this mine were tested in laboratory. The data obtained from laboratory determination were initialized for the value which was defined as “K”. The ratio of each index gas and value of “K”, and the ratio of combination index gases and value of “K”, were analyzed simultaneously. The research results show that for this coal mine, if there is carbon monoxide in the gas sample, the phenomenon of oxidation and temperature rising for coal exists in this mine; if there is C2H4 in the gas sample, the temperature of coal perhaps exceeds 130 °C. If the coal temperature is between 35 °C and 130 °C, prediction and forecast for coal spontaneous combustion depend on the value of Φ(CO)/K mainly; if the temperature of coal is between 130 °C and 300 °C, prediction and forecast for coal spontaneous combustion depend on the value of Φ(C2H6)/Φ(C2H2) and Φ(C2H6)/K. The research results provide experimental basis for the prediction of coal spontaneous combustion in Anyuan coal mine, and have better guidance on safe production of this coal mine.

Multiple questions relating to contributions of cultural and demographical factors in the process of human geographical dispersal remain largely unanswered. India, a land of early human settlement and the resulting diversity is a good place to look for some of the answers. In this study, we explored the genetic structure of India using a diverse panel of 78 males genotyped using the GenoChip. Their genome-wide single-nucleotide polymorphism (SNP) diversity was examined in the context of various covariates that influence Indian gene pool. Admixture analysis of genome-wide SNP data showed high proportion of the Southwest Asian component in all of the Indian samples. Hierarchical clustering based on admixture proportions revealed seven distinct clusters correlating to geographical and linguistic affiliations. Convex hull overlay of Y-chromosomal haplogroups on the genome-wide SNP principal component analysis brought out distinct non-overlapping polygons of F*-M89, H*-M69, L1-M27, O2a-M95 and O3a3c1-M117, suggesting a male-mediated migration and expansion of the Indian gene pool. Lack of similar correlation with mitochondrial DNA clades indicated a shared genetic ancestry of females. We suggest that ancient male-mediated migratory events and settlement in various regional niches led to the present day scenario and peopling of India.