23 results on '"Soliman, O.I.I."'
Search Results
2. Clinical impact and 'natural' course of uncorrected tricuspid regurgitation after implantation of a left ventricular assist device: an analysis of the European Registry for Patients with Mechanical Circulatory Support (EUROMACS)
- Author
-
Veen, K.M. (Kevin), Mokhles, M.M. (Mostafa), Soliman, O.I.I. (Osama Ibrahim Ibrahim), By, T.M.M.H. (Theo) de, Mohacsi, P. (Paul), Schoenrath, F. (Felix), Paluszkiewicz, L. (Lech), Netuka, I. (Ivan), Bogers, A.J.J.C. (Ad J J C), Takkenberg, J.J.M. (Hanneke), Caliskan, K.C. (Kadir), Veen, K.M. (Kevin), Mokhles, M.M. (Mostafa), Soliman, O.I.I. (Osama Ibrahim Ibrahim), By, T.M.M.H. (Theo) de, Mohacsi, P. (Paul), Schoenrath, F. (Felix), Paluszkiewicz, L. (Lech), Netuka, I. (Ivan), Bogers, A.J.J.C. (Ad J J C), Takkenberg, J.J.M. (Hanneke), and Caliskan, K.C. (Kadir) more...
- Abstract
OBJECTIVES: Data on the impact and course of uncorrected tricuspid regurgitation (TR) during left ventricular assist device (LVAD) implantation are scarce and inconsistent. This study explores the clinical impact and natural course of uncorrected TR in patients after LVAD implantation. METHODS: The European Registry for Patients with Mechanical Circulatory Support was used to identify adult patients with LVAD implants without concomitant tricuspid valve surgery. A mediation model was developed to assess the association of TR with 30-day mortality via other risk factors. Generalized mixed models were used to model the course of post-LVAD TR. Joint models were used to perform sensitivity analyses. RESULTS: A total of 2496 procedures were included (median age: 56 years; men: 83%). TR was not directly associated with higher 30-day mortality, but mediation analyses suggested an indirect association via preoperative elevated right atrial pressure and creatinine (P = 0.035) and bilirubin (P = 0.027) levels. Post-LVAD TR was also associated with increased late mortality [hazard ratio 1.16 (1.06-1.3); P = 0.001]. On average, uncorrected TR diminished after LVAD implantation. The probability of having moderate-to-severe TR immediately after an implant in patients with none-to-mild TR pre-LVAD was 10%; in patients with moderate-to-severe TR pre-LVAD, it was 35% and continued to decrease in patients with moderate-to-severe TR pre-LVAD, regardless of pre-LVAD right ventricular failure or pulmonary hypertension. CONCLUSIONS: Uncorrected TR pre-LVAD and post-LVAD is associated with increased early and late mortality. Nevertheless, on average, TR diminishes progre more...
- Published
- 2021
- Full Text
- View/download PDF
Catalog
3. The Effectiveness of Levosimendan on Veno-Arterial Extracorporeal Membrane Oxygenation Management and Outcome: A Systematic Review and Meta-Analysis
- Author
-
Kaddoura, R. (Rasha), Omar, A.S. (Amr S.), Ibrahim, M.I.M. (Mohamed Izham Mohamed), Alkhulaifi, A. (Abdulaziz), Lorusso, R. (Roberto), Elsherbini, H. (Hagar), Soliman, O.I.I. (Osama Ibrahim Ibrahim), Caliskan, K.C. (Kadir), Kaddoura, R. (Rasha), Omar, A.S. (Amr S.), Ibrahim, M.I.M. (Mohamed Izham Mohamed), Alkhulaifi, A. (Abdulaziz), Lorusso, R. (Roberto), Elsherbini, H. (Hagar), Soliman, O.I.I. (Osama Ibrahim Ibrahim), and Caliskan, K.C. (Kadir) more...
- Abstract
Objectives: Veno-arterial extracorporeal membrane oxygenation (VA-ECMO) provides a temporary support system for patients with cardiogenic shock refractory to conventional medical therapies. It has been reported that levosimendan may facilitate VA-ECMO weaning and improve survival. The primary objective of this review was to examine the effect of levosimendan use on VA-ECMO weaning and mortality in critically ill patients on VA-ECMO. Design: MEDLINE, EMBASE, and CENTRAL were searched. A pair of reviewers identified eligible clinical trials. Two reviewers extracted data and independently assessed the risk of bias. A random-effect model was used to combine data. The primary outcome was the success of weaning from VA-ECMO. Measurements and Main Results: Seven studies of observational design, including a total of 630 patients, were selected in the final analysis. The sample size ranged from ten-to-240 patients, with a mean age between 53 and 65 years, and more than half of them underwent cardiac surgeries. The VA-ECMO durations varied between four and 11.6 days. Overall, levosimendan use was significantly associated with successful weaning compared with control (odds ratio [OR] 2.89, 95% CI, 1.53-5.46; poverall effect = 0.001); I2 = 49%). For survival, six studies (n = 617) were included in the meta-analysis involving 326 patients in the levosimendan group and 291 in the comparator group. Pooled results showed a significantly higher survival rate in the levosimendan group (OR 0.46, 95% CI, 0.30-0.71; poverall effect = 0.0004; I2 = 20%). Conclusions: Levosimendan therapy was significantly associated with successful weaning and survival benefit in patients with cardiogenic or postcardiotomy shock needing VA-ECMO support for severe cardiocirculatory compromise. To date, there is limited literature and absence of evidence from randomized trials addressing the use of levosimendan in VA-ECMO weaning. This study may be considered a hypothesis-generating research for randomized more...
- Published
- 2021
- Full Text
- View/download PDF
4. Impact of chronic obstructive pulmonary disease and dyspnoea on clinical outcomes in ticagrelor treated patients undergoing percutaneous coronary intervention in the randomized GLOBAL LEADERS trial
- Author
-
Tomaniak, M. (Mariusz), Chichareon, P. (Ply), Takahashi, K. (Kuniaki), Kogame, N. (Norihiro), Modolo, R. (Rodrigo), Chang, C.C. (Chun Chin), Spitzer, E. (Ernest), Neumann, F.J., Plante, S. (Sylvain), Hernandez-Antolin, R. (Rosana), Jambrik, Z. (Zoltan), Gelev, V. (Valeri), Brunel, P. (Philippe), Konteva, M. (Mariana), Beygui, F. (Farzin), Morelle, J.-F. (Jean-Francois), Filipiak, K.J. (Krzysztof J.), Geuns, R.J.M. (Robert Jan) van, Soliman, O.I.I. (Osama Ibrahim Ibrahim), Tijssen, J.G.P. (Jan), Rademaker-Havinga, T.A.M. (Tessa), Storey, D. (David), Hamm, C. (Christian), Steg, P.G. (Philippe Gabriel), Windecker, S.W. (Stephan), Onuma, Y. (Yoshinobu), Valgimigli, M. (Marco), Serruys, P.W.J.C. (Patrick), Tomaniak, M. (Mariusz), Chichareon, P. (Ply), Takahashi, K. (Kuniaki), Kogame, N. (Norihiro), Modolo, R. (Rodrigo), Chang, C.C. (Chun Chin), Spitzer, E. (Ernest), Neumann, F.J., Plante, S. (Sylvain), Hernandez-Antolin, R. (Rosana), Jambrik, Z. (Zoltan), Gelev, V. (Valeri), Brunel, P. (Philippe), Konteva, M. (Mariana), Beygui, F. (Farzin), Morelle, J.-F. (Jean-Francois), Filipiak, K.J. (Krzysztof J.), Geuns, R.J.M. (Robert Jan) van, Soliman, O.I.I. (Osama Ibrahim Ibrahim), Tijssen, J.G.P. (Jan), Rademaker-Havinga, T.A.M. (Tessa), Storey, D. (David), Hamm, C. (Christian), Steg, P.G. (Philippe Gabriel), Windecker, S.W. (Stephan), Onuma, Y. (Yoshinobu), Valgimigli, M. (Marco), and Serruys, P.W.J.C. (Patrick) more...
- Abstract
AIMS: To evaluate long-term safety and efficacy of ticagrelor monotherapy in patients undergoing percutaneous coronary interventions (PCIs) in relation to chronic obstructive pulmonary disease (COPD) at baseline and the occurrence of dyspnoea reported as adverse event (AE) that may lead to treatment non-adherence. METHODS AND RESULTS: This is a non-prespecified, post hoc analysis of the randomized GLOBAL LEADERS trial (n = 15 991), comparing the experimental strategy of 23-month ticagrelor monotherapy following 1-mon more...
- Published
- 2020
- Full Text
- View/download PDF
5. Uncertainties and challenges in surgical and transcatheter tricuspid valve therapy: a state-of-the-art expert review
- Author
-
Chang, C.C., Veen, K.M., Hahn, R.T. (Rebecca), Bogers, A.J.J.C. (Ad), Latib, A. (Azeem), Oei, F.B.S. (Frans), Abdelghani, M, Modolo, R. (Rodrigo), Ho, S.Y.W. (Simon), Abdel-Wahab, M. (Mohamed), Fattouch, K., Bosmans, J. (Johan), Caliskan, K.C. (Kadir), Taramasso, M., Serruys, P.W.J.C. (Patrick), Bax, JJJ, Mieghem, N.M. (Nicolas) van, Takkenberg, J.J.M., Lurz, P., Modine, T, Soliman, O.I.I. (Osama Ibrahim Ibrahim), Chang, C.C., Veen, K.M., Hahn, R.T. (Rebecca), Bogers, A.J.J.C. (Ad), Latib, A. (Azeem), Oei, F.B.S. (Frans), Abdelghani, M, Modolo, R. (Rodrigo), Ho, S.Y.W. (Simon), Abdel-Wahab, M. (Mohamed), Fattouch, K., Bosmans, J. (Johan), Caliskan, K.C. (Kadir), Taramasso, M., Serruys, P.W.J.C. (Patrick), Bax, JJJ, Mieghem, N.M. (Nicolas) van, Takkenberg, J.J.M., Lurz, P., Modine, T, and Soliman, O.I.I. (Osama Ibrahim Ibrahim) more...
- Abstract
Tricuspid regurgitation (TR) is a frequent and complex problem, commonly combined with left-sided heart disease, such as mitral regurgitation. Significant TR is associated with increased mortality if left untreated or recurrent after therapy. Tricuspid regurgitation was historically often disregarded and remained undertreated. Surgery is currently the only Class I Guideline recommended therapy for TR, in the form of annuloplasty, leaflet repair, or valve replacement. As growing experience of transcatheter therapy in structural heart disease, many dedicated transcatheter tricuspid repair or replacement devices, which mimic well-established surgical techniques, are currently under development. Nevertheless, many aspects of TR are little understood, including the disease process, surgical or interventional risk stratification, and predictors of successful therapy. The optimal treatment timing and the choice of proper surgical or interventional technique for significant TR remain to be elucidated. In this context, we aim to highlight the current evidence, underline major controversial issues in this field and present a future roadmap for TR therapy. more...
- Published
- 2020
- Full Text
- View/download PDF
6. Impact of Continuous Flow Left Ventricular Assist Device Therapy on Chronic Kidney Disease: A Longitudinal Multicenter Study
- Author
-
Yalcin, Y.C. (Yunus C.), Muslem, R. (Rahatullah), Veen, K.M. (Kevin), Soliman, O.I.I. (Osama Ibrahim Ibrahim), Hesselink, D.A. (Dennis), Constantinescu, A.A. (Alina), Brugts, J.J. (Jasper), Manintveld, O.C. (Olivier), Fudim, M. (Marat), Russell, S.D. (Stuart), Tomashitis, B. (Brett), Houston, B.A. (Brian A.), Hsu, S. (Steven), Tedford, R.J. (Ryan), Bogers, A.J.J.C. (Ad), Caliskan, K.C. (Kadir), Yalcin, Y.C. (Yunus C.), Muslem, R. (Rahatullah), Veen, K.M. (Kevin), Soliman, O.I.I. (Osama Ibrahim Ibrahim), Hesselink, D.A. (Dennis), Constantinescu, A.A. (Alina), Brugts, J.J. (Jasper), Manintveld, O.C. (Olivier), Fudim, M. (Marat), Russell, S.D. (Stuart), Tomashitis, B. (Brett), Houston, B.A. (Brian A.), Hsu, S. (Steven), Tedford, R.J. (Ryan), Bogers, A.J.J.C. (Ad), and Caliskan, K.C. (Kadir) more...
- Abstract
Background: Many patients undergoing durable left ventricular assist device (LVAD) implantation suffer from chronic kidney disease (CKD). Therefore, we investigated the effect of LVAD support on CKD. Methods: A retrospective multicenter cohort study, including all patients undergoing LVAD (HeartMate II (n = 330), HeartMate 3 (n = 22) and HeartWare (n = 48) implantation. In total, 227 (56.8%) patients were implanted as bridge-to-transplantation; 154 (38.5%) as destination therapy; and 19 (4.7%) as bridge-to-decision. Serum creatinine measurements were collected over a 2-year follow-up period. Patients were stratified based on CKD stage. Results: Overall, 400 patients (mean age 53 ± 14 years, 75% male) were included: 186 (46.5%) patients had CKD stage 1 or 2; 93 (23.3%) had CKD stage 3a; 82 (20.5%) had CKD stage 3b; and 39 (9.8%) had CKD stage 4 or 5 prior to LVAD implantation. During a median follow-up of 179 days (IQR 28–627), 32,629 creatinine measurements were available. Improvement of kidney function was noticed in every preoperative CKD-stage group. Following this improvement, estimated glomerular filtration rates regressed to baseline values for all CKD stages. Patients showing early renal function improvement were younger and in worse preoperative condition. Moreover, survival rates were higher in patients showing early improvement (69% vs 56%, log-rank P = 0.013). Conclusions: Renal function following LVAD implantation is characterized by improvement, steady state and subsequent deterioration. Patients who showed early renal function improvement were in worse preoperative condition, however, and had higher survival rates at 2 years of follow-up. more...
- Published
- 2020
- Full Text
- View/download PDF
7. Advances in transcatheter mitral and tricuspid therapies
- Author
-
Overtchouk, P. (Pavel), Piazza, N. (Nicolo), Granada, J.F. (Juan), Soliman, O.I.I. (Osama Ibrahim Ibrahim), Prendergast, P.J. (Patrick), Modine, T. (Thomas), Overtchouk, P. (Pavel), Piazza, N. (Nicolo), Granada, J.F. (Juan), Soliman, O.I.I. (Osama Ibrahim Ibrahim), Prendergast, P.J. (Patrick), and Modine, T. (Thomas) more...
- Abstract
BACKGROUND: While rheumatic mitral stenosis has been effectively treated percutaneously for more than 20 years, mitral and tricuspid regurgitation treatment appear as a contemporary unmet need. The advent of transcatheter therapies offer new treatment options to often elderly and frail patients at high risk for open surgery. We aimed at providing an updated review of fast-growing domain of transcatheter mitral and tricuspid technology. MAIN BODY: We reviewed the existing literature on mitral and tricuspid transcatheter therapies. Mitraclip is becoming an established therapy for secondary mitral regurgitation in selected patients with disproportionately severe regurgitation associated with moderate left ventricle dysfunction. Evidence is less convincing for primary mitral regurgitation. Transcatheter mitral valve replacement is a promising emerging alternative to transcatheter repair, for secondary as well as primary mitral regurgitation. But further development is needed to improve delivery. Transcatheter tricuspid intervention arrives late after similar technologies have been developed for aortic and mitral valves and is currently at its infancy. This is likely due in part to previously under-recognized impact of tricuspid regurgitation on patient outcomes. Edge-to-edge repair is the most advanced transcatheter solution in development. Data on tricuspid annuloplasty and replacement is limited, and more research is warranted. CONCLUSION: The future appears bright for transcatheter mitral therapies, albeit their place in clinical practice is yet to be clearly defined. Tricuspid transcatheter therapies might address the unmet need of tricuspid regurgitation treatment. more...
- Published
- 2020
- Full Text
- View/download PDF
8. Causes and predictors of early mortality in patients treated with left ventricular assist device implantation in the European Registry of Mechanical Circulatory Support (EUROMACS)
- Author
-
Akin, S. (Şakir), Soliman, O.I.I. (Osama Ibrahim Ibrahim), de By, T.M.M.H. (Theo M. M. H.), Muslem, R. (Rahatullah), Tijssen, J.G.P. (Jan), Schoenrath, F. (Felix), Meyns, B. (Bart), Gummert, J. (Jan Fritz), Mohacsi, P. (Paul), Caliskan, K.C. (Kadir), Akin, S. (Şakir), Soliman, O.I.I. (Osama Ibrahim Ibrahim), de By, T.M.M.H. (Theo M. M. H.), Muslem, R. (Rahatullah), Tijssen, J.G.P. (Jan), Schoenrath, F. (Felix), Meyns, B. (Bart), Gummert, J. (Jan Fritz), Mohacsi, P. (Paul), and Caliskan, K.C. (Kadir) more...
- Abstract
Purpose: The aim of the study was to analyze early mortality after continuous-flow left ventricular assist device (LVAD) implantation which remains high. Methods: We analyzed consecutive (n = 2689) patients from the European Registry for Patients with Mechanical Circulatory Support (EUROMACS) undergoing continuous-flow LVAD implantation. The primary outcome was early (< 90 days) mortality. Secondary outcomes were differential causes of early post-operative death following LVAD implantation. Results: Univariable and multivariable analysis as well as regression analysis were used to examine determinants and differential causes of early (< 90 days) mortality after LVAD implantation. During the first 90 days, 2160 (80%) patients were alive with ongoing LVAD support, 40(2%) patients underwent heart transplantation, and 487(18%) deceased. The main causes of early death were MOF (36%), sepsis (28%), cardiopulmonary failure (CPF; 10%), CVA (9%), and right-sided heart failure (RHF, 8%). Furthermore, MOF and sepsis are 70% of causes of death in the first week. Independent clinical predictors of early death were age, female sex, INTERMACS profile 1 to 3, and ECMO. Laboratory predictors included elevated serum creatinine, total bilirubin, lactate, and low hemoglobin. Furthermore, hemodynamic predictors included elevated RA-to-PCWP ratio, pulmonary vascular resistance, and low systemic vascular resistance. Longer total implantation time was also independent predictor of early mortality. A simple model of 12 variables predicts early mortality following LVAD implantation with a good discriminative power with area under the curve of 0.75. Conclusions: In the EUROMACS registry, approximately one out of five patients die within 90 days after LVAD implantation. Early mortality is primarily dominated by multiorgan failure followed by sepsis. A simple model identifies important parameters which are associated with early mortality following LVAD implantation. more...
- Published
- 2020
- Full Text
- View/download PDF
9. Clinical outcomes of the Lotus Valve in patients with bicuspid aortic valve stenosis: An analysis from the RESPOND study
- Author
-
Blackman, D.J., Gils, L. (Lennart) van, Bleiziffer, S. (Sabine), Gerckens, U. (Ulrich), Petronio, AS, Abdel-Wahab, M. (Mohamed), Werner, N. (Nikos), Khogali, S.S., Wenaweser, P. (Peter), Wohrle, J., Soliman, O.I.I. (Osama Ibrahim Ibrahim), Laborde, J.C., Allocco, D.J., Meredith, IT, Falk, V. (Volkmar), Mieghem, N.M. (Nicolas) van, Blackman, D.J., Gils, L. (Lennart) van, Bleiziffer, S. (Sabine), Gerckens, U. (Ulrich), Petronio, AS, Abdel-Wahab, M. (Mohamed), Werner, N. (Nikos), Khogali, S.S., Wenaweser, P. (Peter), Wohrle, J., Soliman, O.I.I. (Osama Ibrahim Ibrahim), Laborde, J.C., Allocco, D.J., Meredith, IT, Falk, V. (Volkmar), and Mieghem, N.M. (Nicolas) van more...
- Abstract
Aims: Patients with bicuspid valves represent a challenging anatomical subgroup for transcatheter aortic valve implantation (TAVI). This analysis evaluated the clinical outcomes of the fully repositionable and retrievable Lotus Valve System in patients with bicuspid aortic valves enrolled in the RESPOND post-market registry. Methods and Results: The prospective, open-label RESPOND study enrolled 1,014 patients at 41 centers in Europe, New Zealand, and Latin America, 31 (3.1%) of whom had bicuspid aortic valves. The mean age in the bicuspid patient cohort was 76.4 years, 64.5% were male, and the baseline STS score was 6.0 ± 10.2. Procedural success was 100%, with no cases of malpositioning, valve migration, embolization, or valve-in-valve. Repositioning was attempted in 10 cases (32.3%). There was one death (3.2%) and one stroke (3.2%) at 30-day follow-up. Mean AV gradient was reduced from 48.7 ± 17.0 mmHg at baseline to 11.8 ± 5.1 mmHg at hospital discharge (P < 0.001); mean effective orifice area (EOA) more...
- Published
- 2019
- Full Text
- View/download PDF
10. Right heart failure syndrome
- Author
-
Soliman, O.I.I. (Osama Ibrahim Ibrahim), Muslem, R. (Rahatullah), Caliskan, K.C. (Kadir), Soliman, O.I.I. (Osama Ibrahim Ibrahim), Muslem, R. (Rahatullah), and Caliskan, K.C. (Kadir)
- Published
- 2019
- Full Text
- View/download PDF
11. Inter-technique consistency and prognostic value of intra-procedural angiographic and echocardiographic assessment of aortic regurgitation after transcatheter aortic valve implantation
- Author
-
Tateishi, H. (Hiroki), Miyazaki, Y. (Yosuke), Okamura, T. (Takayuki), Abdelghani, M. (Mohammad), Modolo, R. (Rodrigo), Wada, Y. (Yasuaki), Okuda, S. (Shinichi), Omuro, A. (Ayumi), Ariyoshi, T. (Toru), Fujii, A. (Ayano), Oda, T. (Tetsuro), Fujimura, T. (Tatsuhiro), Nanno, T. (Takuma), Mikamo, A. (Akihito), Soliman, O.I.I. (Osama Ibrahim Ibrahim), Onuma, Y. (Yoshinobu), Hamano, K. (Kimikazu), Yano, M. (Masafumi), Serruys, P.W.J.C. (Patrick), Tateishi, H. (Hiroki), Miyazaki, Y. (Yosuke), Okamura, T. (Takayuki), Abdelghani, M. (Mohammad), Modolo, R. (Rodrigo), Wada, Y. (Yasuaki), Okuda, S. (Shinichi), Omuro, A. (Ayumi), Ariyoshi, T. (Toru), Fujii, A. (Ayano), Oda, T. (Tetsuro), Fujimura, T. (Tatsuhiro), Nanno, T. (Takuma), Mikamo, A. (Akihito), Soliman, O.I.I. (Osama Ibrahim Ibrahim), Onuma, Y. (Yoshinobu), Hamano, K. (Kimikazu), Yano, M. (Masafumi), and Serruys, P.W.J.C. (Patrick) more...
- Abstract
Background: We investigated the relationship between intraprocedural angiographic and echocardiographic AR severity after TAVI, and the clinical robustness of angiographic assessment. Methods and Results: In 74 consecutive patients, the echocardiographic circumferential extent (CE) of the paravalvular regurgitant jet was retrospectively measured and graded based on the VARC-2 cut-points; and angiographic post-TAVI AR was retrospectively quantified using contrast videodensitometry (VD) software that calculates the ratio of the contrast time-density integral in the LV outflow tract to that in the ascending aorta (LVOT-AR). Seventy-four echocardiograms immediately after TAVI were analyzable, while 51 aortograms were analyzable for VD. These 51 echocardiograms and VD were evaluated. Median LVOT-AR across the echocardiographic AR grades was as follows: none-trace, 0.07 (IQR, 0.05–0.11); mild, 0.12 (IQR, 0.09–0.15); and moderate, 0.17 (IQR, 0.15–0.22; P<0.05 for none-trace vs. mild, and mild vs. moderate). LVOT-AR strongly correlated with %CE (r=0.72, P<0.0001). At 1 year, the rate of the composite end-point of all-cause death or HF re-hospitalization was significantly higher in >mild AR patients compared with no-mild AR on intra-procedural echocardiography (41.5% vs. 12.4%, P=0.03) as well as in patients with LVOT-AR >0.17 compared with LVOT-AR ≤0.17 (59.5% vs. 16.6%, P=0.03). Conclusions: VD (LVOT-AR) has good intra-procedural inter-technique consistency and clinical robustness. Greater than mild post-TAVI AR, but not mild post-TAVI AR, is associated with late mortality. more...
- Published
- 2018
- Full Text
- View/download PDF
12. Videodensitometric quantification of paravalvular regurgitation of a transcatheter aortic valve: in vitro validation.
- Author
-
Abdelghani, M., Miyazaki, Y., de Boer, E.S., Aben, J.P., van Sloun, M., Suchecki, T., van 't Veer, M., Soliman, O.I.I., Onuma, Y., de Winter, R., Tonino, P., van de Vosse, F.N., Rutten, M.C.M., Serruys, P.W., Abdelghani, M., Miyazaki, Y., de Boer, E.S., Aben, J.P., van Sloun, M., Suchecki, T., van 't Veer, M., Soliman, O.I.I., Onuma, Y., de Winter, R., Tonino, P., van de Vosse, F.N., Rutten, M.C.M., and Serruys, P.W. more...
- Abstract
Aims: Videodensitometric assessment of aortography provides a periprocedural quantitation of prosthetic valve regurgitation (PVR) after transcatheter aortic valve implantation. We sought to compare the videodensitometric parameters of PVR severity to the regurgitation fraction (RF) in a controlled in vitro setting. Methods and results: In a mock circulation system, a transcatheter balloon-expandable valve inserted at the aortic valve position was gradually deformed to induce different grades of paravalvular leakage and the RF was measured with a transonic flow probe. Contrast aortography was performed and the following videodensitometric parameters were generated: left ventricle aortic regurgitation (LV-AR), LV outflow tract AR (LVOT-AR), quantitative regurgitation assessment (qRA) index, relative maximum density (relative max), and maximum upslope of the LV time-density curve. The correlation was substantial between videodensitometric parameters (LV-AR, LVOT-AR, qRA index, relative max, and maximum upslope) and RF (r 2=0.96, 0.96, 0.93, 0.87, and 0.93; p<0.001 for all). LV-AR (region of interest [ROI]=entire LV) and LVOT-AR (ROI=LVOT) were not different (p=0.51) and were strongly correlated (r 2=0.99) with a mean difference of 1.92% (95% limits of agreement: ±2.83). The correlations of LV-AR and LVOT-AR with RF were stronger when more than one cardiac cycle was included in the analysis (one cycle: r 2=0.85 and r 2=0.83; four cycles: r 2=0.96 and r 2=0.96, for LV-AR and LVOT-AR, respectively). Including more cycles beyond four did not improve accuracy. Conclusions: Quantitative assessment of PVR by videodensitometry of aortograms strongly correlates with the actual RF in a controlled in vitro setting. Accuracy is improved by including more than one cardiac cycle in the analysis. more...
- Published
- 2018
13. Percutaneous left atrial appendage occlusion: The Munich consensus document on definitions, endpoints, and data collection requirements for clinical studies
- Author
-
Tzikas, A. (Apostolos), Holmes, D.R. (David), Gafoor, S. (Sameer), Ruiz, C.E. (Carlos), Blomstrom-Lundqvist, C., Diener, H.C. (Hans Christoph), Cappato, R. (Riccardo), Kar, S. (Saibal), Lee, R.J. (Randal J.), Byrne, R.A. (Robert), Ibrahim, R. (Reda), Lakkireddy, D. (Dhanunjaya), Soliman, O.I.I. (Osama Ibrahim Ibrahim), Näbauer, M. (Michael), Schneider, S. (Steffen), Brachmann, J. (Johannes), Saver, J.L. (Jeffrey L.), Tiemann, M., Sievert, H., Camm, A.J. (A. John), Lewalter, T. (Thorsten), Tzikas, A. (Apostolos), Holmes, D.R. (David), Gafoor, S. (Sameer), Ruiz, C.E. (Carlos), Blomstrom-Lundqvist, C., Diener, H.C. (Hans Christoph), Cappato, R. (Riccardo), Kar, S. (Saibal), Lee, R.J. (Randal J.), Byrne, R.A. (Robert), Ibrahim, R. (Reda), Lakkireddy, D. (Dhanunjaya), Soliman, O.I.I. (Osama Ibrahim Ibrahim), Näbauer, M. (Michael), Schneider, S. (Steffen), Brachmann, J. (Johannes), Saver, J.L. (Jeffrey L.), Tiemann, M., Sievert, H., Camm, A.J. (A. John), and Lewalter, T. (Thorsten) more...
- Abstract
The increasing interest in left atrial appendage occlusion (LAAO) for ischaemic stroke prevention in atrial fibrillation (AF) fuels the need for more
- Published
- 2017
- Full Text
- View/download PDF
14. Delayed and decreased LVuntwist and unstrain rate in mutation carriers for hypertrophic cardiomyopathy
- Author
-
Kauer, F. (Floris), Dalen, B.M. (Bas) van, Michels, M. (Michelle), Schinkel, A.F.L. (Arend), Vletter, W.B. (Wim), Slegtenhorst, M.A. (Marjon) van, Soliman, O.I.I. (Osama Ibrahim Ibrahim), Geleijnse, M.L. (Marcel), Kauer, F. (Floris), Dalen, B.M. (Bas) van, Michels, M. (Michelle), Schinkel, A.F.L. (Arend), Vletter, W.B. (Wim), Slegtenhorst, M.A. (Marjon) van, Soliman, O.I.I. (Osama Ibrahim Ibrahim), and Geleijnse, M.L. (Marcel) more...
- Abstract
Background The echocardiographic focus to detect abnormalities in genetically hypertrophic cardiomyopathy (HCM) affected subjects without left ventricular (LV) hypertrophy (G+/LVH-) has been on diastolic abnormalities in transmitral flow and longitudinal myocardial function with tissue Doppler imaging. The aim of this study was to assess diastolic LV unstrain and untwist. Methods and results Forty-one consecutive genotyped family members of HCM patients (mean age 37611 years, 16 men) and 41 ageand gender-matched healthy volunteers underwent speckle-tracking echocardiography to measure untwist and unstrain. No significant differences between G+/LVH- and control subjects were seen in maximal systolic twist and global longitudinal strain. In diastole, the early peak untwist rate was significantly lower in G+/LVH- subjects compared with control subjects (62±19°s-1 vs. 76±30°s-1, P<0.05), whereas the late peak untwist rate tended to be higher. Untwist from maximal twist until the first 20% of diastole was delayed in G+/LVH- subjects (39.3612.9% vs. 51.3±15.6%, P<0.005). Late diastolic unstrain rate was significantly higher in G+/LVH- subjects in the inferoseptal wall (111±33 s-1 vs. 94±32 s-1, P=0.024), the inferolateral wall (105±42 vs. 75±35 s-1, P=0.007) and the anteroseptal wall (97±26 vs. 80±23 s-1, P=0.010). Unstrain from maximal twist until the first 20% of diastole was delayed in G+/LVH- subjects in the inferoseptal (18.9614.0% vs. 30.1±17.7%, P=0.005), inferolateral (27.1±16.3% vs. 39.2±18.0%, P=0.015) and anteroseptal (19.1±14.7% vs. 35.8±18.5%, P=0.0003) segments. Conclusions In mutation carriers, for HCM LV, untwist and unstrain are delayed and untwist rate more...
- Published
- 2017
- Full Text
- View/download PDF
15. Relation between calciumburden, echocardiographic stent frame eccentricity and paravalvular leakage after corevalve transcatheter aortic valve implantation
- Author
-
Di Martino, L.F.M. (Luigi F. M.), Soliman, O.I.I. (Osama Ibrahim Ibrahim), Gils, L. (Lennart) van, Vletter, W.B. (Wim), Mieghem, N.M. (Nicolas) van, Ren, B. (Ben), Galema, T.W. (Tjebbe), Schultz, C. (Carl), Jaegere, P.P.T. (Peter) de, Di Biase, M. (Matteo), Geleijnse, M.L. (Marcel), Di Martino, L.F.M. (Luigi F. M.), Soliman, O.I.I. (Osama Ibrahim Ibrahim), Gils, L. (Lennart) van, Vletter, W.B. (Wim), Mieghem, N.M. (Nicolas) van, Ren, B. (Ben), Galema, T.W. (Tjebbe), Schultz, C. (Carl), Jaegere, P.P.T. (Peter) de, Di Biase, M. (Matteo), and Geleijnse, M.L. (Marcel) more...
- Abstract
Aims Paravalvular aortic leakage (PVL) after transcatheter aortic valve implantation (TAVI) is a complication with potentially severe consequences. The relation between native aortic root calcium burden, stent frame eccentricity and PVL was not studied before. Methods and results Two-hundred-and-twenty-three consecutive patients with severe aortic stenosis who underwent TAVI with a Medtronic CoreValve SystemVC and who had available pre-discharge transthoracic echocardiography were studied. Echocardiographic stent inflow frame eccentricity was defined as major-minor diameter in a short-axis view >2 mm. PVL was scored according to the updated Valve Academic Research Consortium (VARC-2) recommendations. In a subgroup of 162 (73%) patients, the calcium Agatston score was available. Stent frame eccentricity was seen in 77 (35%) of patients. The correlation between the Agatston score and stent frame eccentricity was significant (q = 0.241, P = 0.003). Paravalvular leakage was absent in 91 cases (41%), mild in 67 (30%), moderate in 51 (23%), and severe in 14 (6%) cases. The correlation between stent frame eccentricity and PVL severity was significant (q = 0.525, P < 0.0001). There was a relation between particular eccentric stent frame shapes and the site of PVL. Conclusion Calcification of the aortic annulus is associated with a subsequent eccentric shape of the CoreValve prosthesis. This eccentric shape results in more PVL, with the localization of PVL related to the shape of stent frame. more...
- Published
- 2017
- Full Text
- View/download PDF
16. Functional evaluation of sublingual microcirculation indicates successful weaning from VA-ECMO in cardiogenic shock
- Author
-
Akin, S. (Şakir), Reis Miranda, D. (Dinis) dos, Caliskan, K.C. (Kadir), Soliman, O.I.I. (Osama Ibrahim Ibrahim), Guven, G. (Goksel), Struijs, A. (Ard), Thiel, R.J. (Robert) van, Jewbali, L.S.D. (Lucia), Lima, A.A.P. (Alexandre ), Gommers, D.A.M.P.J. (Diederik), Zijlstra, F. (Felix), Ince, C. (Can), Akin, S. (Şakir), Reis Miranda, D. (Dinis) dos, Caliskan, K.C. (Kadir), Soliman, O.I.I. (Osama Ibrahim Ibrahim), Guven, G. (Goksel), Struijs, A. (Ard), Thiel, R.J. (Robert) van, Jewbali, L.S.D. (Lucia), Lima, A.A.P. (Alexandre ), Gommers, D.A.M.P.J. (Diederik), Zijlstra, F. (Felix), and Ince, C. (Can) more...
- Abstract
Background: Veno-arterial extracorporeal membrane oxygenation (VA-ECMO) is increasingly adopted for the treatment of cardiogenic shock (CS). However, a marker of successful weaning remains largely unknown. Our hypothesis was that successful weaning is associated with sustained microcirculatory function during ECMO flow reduction. Therefore, we sought to test the usefulness of microcirculatory imaging in the same sublingual spot, using incident dark field (IDF) imaging in assessing successful weaning from VA-ECMO and compare IDF imaging with echocardiographic parameters. Methods: Weaning was performed by decreasing the VA-ECMO flow to 50% (F50) from the baseline. more...
- Published
- 2017
- Full Text
- View/download PDF
17. A novel synchronised diastolic injection method to reduce contrast volume during aortography for aortic regurgitation assessment: in vitro experiment of a transcatheter heart valve model
- Author
-
Miyazaki, Y., Abdelghani, M., de Boer, E.S., Aben, J.P., van Sloun, M., Suchecki, T., van't Veer, M., Collet, C., Asano, T., Katagiri, Y., Tenekecioglu, E., Soliman, O.I.I., Onuma, Y., de Winter, R., Tonino, P., van de Vosse, F.N., Rutten, M.C.M., Serruys, P.W., Miyazaki, Y., Abdelghani, M., de Boer, E.S., Aben, J.P., van Sloun, M., Suchecki, T., van't Veer, M., Collet, C., Asano, T., Katagiri, Y., Tenekecioglu, E., Soliman, O.I.I., Onuma, Y., de Winter, R., Tonino, P., van de Vosse, F.N., Rutten, M.C.M., and Serruys, P.W. more...
- Abstract
Aims: In the minimalist transcatheter aortic valve implantation (TAVI) era, the usage of transoesophageal echocardiography has become restricted. Conversely, aortography has gained clinical ground in quantifying prosthetic valve regurgitation (PVR) during the procedure. In a mock circulation system, we sought to compare the contrast volume required and the accuracy of aortographic videodensitometric PVR assessment using a synchronised diastolic and standard (non-synchronised) injection aortography. Methods and results: Synchronised diastolic injection triggered by the signal stemming from the mock circulation was compared with standard non-synchronised injection. A transcatheter heart valve was implanted and was deformed step by step by advancing a screw perpendicularly to the cage of the valve in order to create increasing PVR. Quantitative measurement of PVR was derived from time-density curves of both a reference area (aortic root) and a region of interest (left ventricle) developed by a videodensitometric software. The volume of contrast required for the synchronised diastolic injection was significantly less than in the non-synchronised injection (8.1 [7.9-8.5] ml vs. 19.4 [19.2-19.9] ml, p<0.001). The correlation between the two methods was substantial (Spearman's coefficient rho ranging from 0.991 to 0.968). Intraobserver intra-class correlation coefficient for both methods of injection was 0.999 (95% CI: 0.996-1.000) for the synchronised diastolic and 0.999 (95% CI: 0.996-1.000) for the non-synchronised injection group. The mean difference in the rating was 0.17% and limits of agreement were ±1.64% for both groups. Conclusions: A short synchronised diastolic injection enables contrast volume reduction during aortography without compromising the accuracy of the quantitative assessment of PVR using videodensitometry. more...
- Published
- 2017
18. P1449A new method to measure circumferential extent of paravalvular leakage after transcatheter aortic valve implantation: i-rotate echocardiography
- Author
-
Spitzer, E., primary, Di Martino, L.F.M., additional, McGhie, J.S., additional, Ren, B., additional, Soliman, O.I.I., additional, Van Mieghem, N.M., additional, De Jaegere, P.P.T., additional, and Geleijnse, M.L., additional more...
- Published
- 2017
- Full Text
- View/download PDF
19. 4993Preoperative right heart hemodynamics predict right heart failure and early ICU mortality following LVAD implantation
- Author
-
Akin, S., primary, Soliman, O.I.I., additional, Muslem, R., additional, Dos Reis Miranda, D., additional, Den Uil, C.A., additional, Constantinescu, A.A., additional, Kardys, I., additional, Bogers, A.J.J.C., additional, Zijlstra, F., additional, Brugts, J.J., additional, and Caliskan, K., additional more...
- Published
- 2017
- Full Text
- View/download PDF
20. Multimodality imaging for left ventricular hypertrophy severity grading: A methodological review
- Author
-
Alkema, M. (Maaike), Spitzer, E. (Ernest), Soliman, O.I.I. (Osama Ibrahim Ibrahim), Loewe, C. (Christian), Alkema, M. (Maaike), Spitzer, E. (Ernest), Soliman, O.I.I. (Osama Ibrahim Ibrahim), and Loewe, C. (Christian) more...
- Abstract
Left ventricular hypertrophy (LVH), defined by an increase in left ventricular mass (LVM), is a common cardiac finding generally caused by an increase in pressure or volume load. Assessing severity of LVH is of great clinical value in terms of prognosis and treatment choices, as LVH severity grades correlate with the risk for presenting cardiovascular events. The three main cardiac parameters for the assessment of LVH are wall thickness, LVM, and LV geometry. Echocardiography, with large availability and low cost, is the technique of choice for their assessment. Consequently, reference values for LVH severity in clinical guidelines are based on this technique. However, cardiac magnetic resonance (CMR) and computed tomography (CT) are increasingly used in clinical practice, providing excellent image quality. Nevertheless, there is no extensive data to support reference values based on these techniques, while comparative studies between the three techniques show different results in wall thickness and LVM measurements. In this paper, we provide an overview of the different methodologies used to assess LVH severity with echocardiography, CMR and CT. We argue that establishing reference values per imaging modality, and possibly indexed to body surface area and classified per gender, ethnicity and age-group, might be essential for the correct classification of LVH severity. more...
- Published
- 2016
- Full Text
- View/download PDF
21. Real-world feasibility of the VARC-recommended multiparametric approach for the assessment of post-TAVI aortic regurgitation
- Author
-
Abdelghani, M. (Mohammad), Spitzer, E. (Ernest), Ren, B. (Ben), Serruys, P.W.J.C. (Patrick), Soliman, O.I.I. (Osama Ibrahim Ibrahim), Abdelghani, M. (Mohammad), Spitzer, E. (Ernest), Ren, B. (Ben), Serruys, P.W.J.C. (Patrick), and Soliman, O.I.I. (Osama Ibrahim Ibrahim) more...
- Published
- 2016
- Full Text
- View/download PDF
22. Haemolysis as a first sign of thromboembolic event and acute pump thrombosis in patients with the continuous-flow
- Author
-
Akin, S. (Şakir), Soliman, O.I.I. (Osama Ibrahim Ibrahim), Constantinescu, A.A. (Alina), Akca, F. (Ferdi), Birim, O. (Ozcan), Domburg, R.T. (Ron) van, Manintveld, O.C. (Olivier), Caliskan, K.C. (Kadir), Akin, S. (Şakir), Soliman, O.I.I. (Osama Ibrahim Ibrahim), Constantinescu, A.A. (Alina), Akca, F. (Ferdi), Birim, O. (Ozcan), Domburg, R.T. (Ron) van, Manintveld, O.C. (Olivier), and Caliskan, K.C. (Kadir) more...
- Abstract
Background Despite advances in pump technology, thromboembolic events/acute pump thrombosis remain potentially life-threatening complications in patients with continuous-flow left ventricular assist devices (CF-LVAD). We sought to determine early signs of thromboembolic event/ pump thrombosis in patients with CF-LVAD, which could lead to earlier intervention. Methods We analysed all HeartMate II recipients (n = 40) in our centre between December 2006 and July 2013. Thromboembolic event/pump thrombosis was defined as a transient ischaemic attack (TIA), ischaemic cerebrovascular accident (CVA), or pump thrombosis. Results During median LVAD support of 336 days [IQR: 182–808], 8 (20%) patients developed a thromboembolic event/pump thrombosis (six TIA/CVA, two pump thromboses). At the time of the thromboembolic event/pump thrombosis, significantly higher pump power was seen compared with the no-thrombosis group (8.2 ± 3.0 vs. 6.4 ± 1.4 W, p = 0.02), as well as a trend towards a lower pulse index (4.1 ± 1.5 vs. 5.0 ± 1.0, p = 0.05) and a trend towards higher pump flow (5.7 ± 1.0 vs. 4.9 ± 1.9 L m, p = 0.06). The thrombosis group had a more than fourfold higher lactate dehydrogenase (LDH) median 1548 [IQR: 754– 2379] vs. 363 [IQR: 325–443] U/L, p = 0.0001). Bacterial (n = 4) or viral (n = 1) infection was present in 5 out of 8 patients. LDH > 735 U/L predicted thromboembolic events/ pump thrombosis with a positive predictive value of 88%. Conclusions In patients with a CF-LVAD (HeartMate II), thromboembolic events and/or pump thrombosis are associated with symptoms and signs of acute haemolysis as manifested by a high LDH, elevated pump power and decreased pulse index, especially in the context of an infection. more...
- Published
- 2016
- Full Text
- View/download PDF
23. Prediction of paravalvular leakage after transcatheter aortic valve implantation
- Author
-
Di Martino, L.F.M. (Luigi F. M.), Vletter, W.B. (Wim), Ren, B. (Ben), Schultz, C. (Carl), Mieghem, N.M. (Nicolas) van, Soliman, O.I.I. (Osama Ibrahim Ibrahim), Di Biase, M. (Matteo), Jaegere, P.P.T. (Peter) de, Geleijnse, M.L. (Marcel), Di Martino, L.F.M. (Luigi F. M.), Vletter, W.B. (Wim), Ren, B. (Ben), Schultz, C. (Carl), Mieghem, N.M. (Nicolas) van, Soliman, O.I.I. (Osama Ibrahim Ibrahim), Di Biase, M. (Matteo), Jaegere, P.P.T. (Peter) de, and Geleijnse, M.L. (Marcel) more...
- Abstract
Significant paravalvular leakage (PVL) after transcatheter aortic valve implantation (TAVI) is related to patient mortality. Predicting the development of PVL has focused on computed tomography (CT) derived variables but literature targeting CoreValve devices is limited, controversial, and did not make use of standardized echocardiographic methods. The study included 164 consecutive patients with severe aortic stenosis that underwent TAVI with a Medtronic CoreValve system©, with available pre-TAVI CT and pre-discharge transthoracic echocardiography. The predictive value for significant PVL of the CT-derived Agatston score, aortic annulus size and eccentricity, and “cover index” was assessed, according to both echocardiographic Valve Academic Research Consortium (VARC) criteria and angiographic Sellers criteria. Univariate predictors for more than mild PVL were the maximal diameter of the aortic annulus size (for both angiographic and echocardiographic assessment of PVL), cover index (for echocardiographic assessment of PVL only), and Agatston score (for more...
- Published
- 2015
- Full Text
- View/download PDF
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.