548 results on '"Spring, David R."'
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2. Towards the Targeted Protein Degradation of PRMT1
3. Tuneable thiol exchange linkers for traceless drug release applications in prodrugs and ADCs.
4. CK2 Inhibitors Targeting Inside and Outside the Catalytic Box
5. Unlocking Amides: A General Method for the Self‐Immolative Release of Amide‐Containing Molecules
6. Site-selective peptide functionalisation mediated via vinyl-triazine linchpins
7. Red-light modulated ortho-chloro azobenzene photoswitch for peptide stapling via aromatic substitution
8. Photoredox C(2)-Arylation of Indole- and Tryptophan-Containing Biomolecules.
9. Microscopy and chemical analyses reveal flavone-based woolly fibres extrude from micron-sized holes in glandular trichomes of Dionysia tapetodes
10. Energetics of lipid transport by the ABC transporter MsbA is lipid dependent
11. Tryptophan in Multicomponent Petasis Reactions for Peptide Stapling and Late‐Stage Functionalisation
12. Synthesis of structurally diverse biflavonoids
13. Novel non-ATP competitive small molecules targeting the CK2 α/β interface
14. A fragment-based approach leading to the discovery of a novel binding site and the selective CK2 inhibitor CAM4066
15. A cryptic hydrophobic pocket in the polo-box domain of the polo-like kinase PLK1 regulates substrate recognition and mitotic chromosome segregation
16. A recombinant approach for stapled peptide discovery yields inhibitors of the RAD51 recombinase.
17. A cell-active cyclic peptide targeting the Nrf2/Keap1 protein–protein interaction.
18. Hybrid Androgen Receptor Inhibitors Outperform Enzalutamide and EPI‐001 in in vitro Models of Prostate Cancer Drug Resistance
19. Studies Towards the Synthesis of the Core of Endiandric Acid H
20. Selective inhibitors of the Aurora A-TPX2 protein-protein interaction exhibit in vivo efficacy as targeted anti-mitotic agents
21. A Recombinant Approach For Stapled Peptide Discovery Yields Inhibitors of the RAD51 Recombinase
22. The human proton pump inhibitors inhibit Mycobacterium tuberculosis rifampicin efflux and macrophage-induced rifampicin tolerance
23. Front Cover: Hybrid Androgen Receptor Inhibitors Outperform Enzalutamide and EPI‐001 in in vitro Models of Prostate Cancer Drug Resistance (ChemMedChem 2/2023)
24. Identification of macrocyclic peptides which activate bacterial cylindrical proteases
25. Synthesis of sp3-rich heterocyclic frameworks by a divergent synthesis strategy
26. Peroxide-cleavable linkers for antibody–drug conjugates
27. Disulfide re-bridging reagents for single-payload antibody-drug conjugates
28. A cell-active peptide targeting the Nrf2/Keap1 protein-protein interaction
29. An expedient strategy for the diversity-oriented synthesis of macrocyclic compounds with natural product-like characteristics
30. Chapter 2. The Application of Diversity-oriented Synthesis in Chemical Biology
31. Divergent and concise total syntheses of dihydrochalcones and 5-deoxyflavones recently isolated from Tacca species and Mimosa diplotricha
32. Overcoming Chemical, Biological, and Computational Challenges in the Development of Inhibitors Targeting Protein-Protein Interactions
33. Studies towards the synthesis of indolizin-5(3H)-one derivatives and related 6,5-azabicyclic scaffolds by ring-closing metathesis
34. Multifunctional supramolecular polymer networks as next-generation consolidants for archaeological wood conservation
35. Divinylpyrimidine reagents generate antibody-drug conjugates with excellent in vivo efficacy and tolerability
36. LGR5 targeting molecules as therapeutic agents for multiple cancer types
37. Synthesis of sp3-rich heterocyclic frameworks by a divergent synthesis strategy.
38. Antiplasmodial and trypanocidal activity of violacein and deoxyviolacein produced from synthetic operons
39. Rapid and robust cysteine bioconjugation with vinylheteroarenes
40. Hybrid Androgen Receptor Inhibitors Outperform Enzalutamide and EPI‐001 in in vitro Models of Prostate Cancer Drug Resistance.
41. A two-component 'double-click' approach to peptide stapling
42. A unified in vitro to in vivo fluorescence lifetime screening platform yields amyloid β aggregation inhibitors
43. Antibody dual-functionalisation enabled through a modular divinylpyrimidine disulfide rebridging strategy
44. Non-internalising antibody–drug conjugates
45. Divinylpyrimidine reagents generate antibody–drug conjugates with excellent in vivo efficacy and tolerability
46. All-in-one disulfide bridging enables the generation of antibody conjugates with modular cargo loading
47. Development of small cyclic peptides targeting the CK2α/β interface
48. Correction: The multifaceted nature of antimicrobial peptides: current synthetic chemistry approaches and future directions
49. A fragment-based approach leading to the discovery of inhibitors of CK2α with a novel mechanism of action
50. Targeting a Novel KRAS Binding Site: Application of One-Component Stapling of Small (5–6-mer) Peptides
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